13,074 results on '"Yu, Jiang"'
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52. CVECenter: Industry Practice of Automated Vulnerability Management for Linux Distribution Community.
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Jing Luo, Heyuan Shi, Yongchao Zhang, Runzhe Wang, Yuheng Shen, Yuao Chen, Xiaohai Shi, Rongkai Liu, Chao Hu, and Yu Jiang 0001
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- 2024
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53. When Fuzzing Meets LLMs: Challenges and Opportunities.
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Yu Jiang 0001, Jie Liang 0006, Fuchen Ma, Yuanliang Chen, Chijin Zhou, Yuheng Shen, Zhiyong Wu 0010, Jingzhou Fu, Mingzhe Wang, Shanshan Li 0001, and Quan Zhang
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- 2024
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54. Human-Imperceptible Retrieval Poisoning Attacks in LLM-Powered Applications.
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Quan Zhang, Binqi Zeng, Chijin Zhou, Gwihwan Go, Heyuan Shi, and Yu Jiang 0001
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- 2024
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55. Dodrio: Parallelizing Taint Analysis Based Fuzzing via Redundancy-Free Scheduling.
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Jie Liang 0006, Mingzhe Wang, Chijin Zhou, Zhiyong Wu 0010, Jianzhong Liu, and Yu Jiang 0001
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- 2024
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56. WingFuzz: Implementing Continuous Fuzzing for DBMSs.
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Jie Liang 0006, Zhiyong Wu 0010, Jingzhou Fu, Yiyuan Bai, Qiang Zhang, and Yu Jiang 0001
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- 2024
57. PEFA: Parameter-Free Adapters for Large-scale Embedding-based Retrieval Models.
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Wei-Cheng Chang, Jyun-Yu Jiang, Jiong Zhang, Mutasem Al-Darabsah, Choon Hui Teo, Cho-Jui Hsieh, Hsiang-Fu Yu, and S. V. N. Vishwanathan
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- 2024
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58. PatchBert: Continuous Stable Patch Identification for Linux Kernel via Pre-trained Model Fine-tuning.
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Rongkai Liu, Heyuan Shi, Yongchao Zhang, Runzhe Wang, Yuheng Shen, Yuao Chen, Jing Luo, Xiaohai Shi, Chao Hu, and Yu Jiang
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- 2024
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59. Jigsaw: Authoring Immersive Storytelling Experiences with Augmented Reality and Internet of Things.
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Lei Zhang, Daekun Kim, Youjean Cho, Ava Robinson, Yu Jiang Tham, Rajan Vaish, and Andrés Monroy-Hernández
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- 2024
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60. A Fast Algorithm for Finding a Safe Steady State Point for Asynchronous RM Real-Time Systems
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Yang, Guide, Yu, Jiang, Tang, Keke, Tian, Zhihong, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Gu, Zhaoquan, editor, Zhou, Wanlei, editor, Zhang, Jiawei, editor, Xu, Guandong, editor, and Jia, Yan, editor
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- 2024
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61. Exploration of Building a Lean Energy Service System Based on Digital Economy
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Yu, Jiang, Liu, Shuqi, Tang, Xiao, Yu, Jin, Lan, Senlin, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Pei, Yan, editor, Ma, Hao Shang, editor, Chan, Yu-Wei, editor, and Jeong, Hwa-Young, editor
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- 2024
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62. microRNA-622 upregulates cell cycle process by targeting FOLR2 to promote CRC proliferation
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Chen, Yuehong, Liu, Feng, Chen, Xinhua, Li, Wenyi, Li, Kejun, Cai, Hailang, Wang, Shunyi, Wang, Honglei, Xu, Ke, Zhang, Chenxi, Ye, Shengzhi, Shen, Yunhao, Mou, Tingyu, Cai, Shumin, Zhou, Jianwei, and Yu, Jiang
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- 2024
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63. Multi-parameter dimensional split preconditioner for three-by-three block system of linear equations
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Ai-Li, Yang, Jun-Li, Zhu, and Yu-Jiang, Wu
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- 2024
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64. P53: A Key Target in the Development of Osteoarthritis
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Ma, Wentao, Tan, Xiaoqian, Xie, Zhongcheng, Yu, Jiang, Li, Pin, Lin, Xiaoyan, Ouyang, Siyu, Liu, Zhiyang, Hou, Qin, Xie, Nan, Peng, Tianhong, Li, Liang, Dai, Zhu, Chen, Xi, and Xie, Wei
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- 2024
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65. Supporting Piggybacked Co-Located Leisure Activities via Augmented Reality
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Reig, Samantha, Cruz, Erica Principe, Powers, Melissa M., He, Jennifer, Chong, Timothy, Tham, Yu Jiang, Kratz, Sven, Robinson, Ava, Smith, Brian A., Vaish, Rajan, and Monroy-Hernández, Andrés
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Computer Science - Human-Computer Interaction ,Computer Science - Computers and Society - Abstract
Technology, especially the smartphone, is villainized for taking meaning and time away from in-person interactions and secluding people into "digital bubbles". We believe this is not an intrinsic property of digital gadgets, but evidence of a lack of imagination in technology design. Leveraging augmented reality (AR) toward this end allows us to create experiences for multiple people, their pets, and their environments. In this work, we explore the design of AR technology that "piggybacks" on everyday leisure to foster co-located interactions among close ties (with other people and pets. We designed, developed, and deployed three such AR applications, and evaluated them through a 41-participant and 19-pet user study. We gained key insights about the ability of AR to spur and enrich interaction in new channels, the importance of customization, and the challenges of designing for the physical aspects of AR devices (e.g., holding smartphones). These insights guide design implications for the novel research space of co-located AR.
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- 2023
66. Structural evolvement of 1-methyl-3,4,5-trinitropyrazole at high pressure
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Guang-yu Qi, Ye Cao, Tian-yu Jiang, Hong Zhang, and Yi Wang
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1-Methyl-3,4,5-trinitropyrazole (MTNP) ,High pressure ,Diamond anvil cell (DAC) ,Raman spectrum ,Synchrotron angle-dispersive X-ray diffraction (ADXRD) ,Chemical technology ,TP1-1185 - Abstract
Explosives, a type of energetic material (EM), face a high-pressure environment in the detonation process or under shock conditions. Determining their high-pressure behavior is critical to their explosion and safety. 1-Methyl-3,4,5-trinitropyrazole (MTNP), a carrier of melt-cast explosives, exhibits the potential for replacing trinitrotoluene (TNT). However, there is limited knowledge about its structural evolvement at high pressure. Using a diamond anvil cell (DAC), this study investigated the structural variation of MTNP through in situ high-pressure synchrotron angle-dispersive X-ray diffraction (ADXRD) experiments and Raman measurements. As evidenced by the results, MTNP underwent phase transition at 8.7 GPa and amorphization at 15.3 GPa due to high pressure. Through the analysis of first-principles calculations and Raman spectra, this study proposed the mechanisms behind the changes in MTNP at high pressure. Furthermore, this study systematically explored the structural evolvement of MTNP and the evolution of its weak intermolecular interactions at high pressure, gaining further understanding of MTNP's detonation and safety.
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- 2024
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67. Edible‐plant derived 2′,4′‐dihydroxy‐6′‐methoxy‐3′,5′‐dimethylchalcone exert dual effects on invigorating triple‐negative breast cancer apoptosis
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Tingting Yu, Yu Jiang, Miaomiao Guo, Xing Wei, Xiujuan Xin, and Faliang An
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DMC ,G2/M arrest ,MDA‐MB‐231 cells ,PI3K/Akt/mTOR pathway ,β‐tubulin binding ,Food processing and manufacture ,TP368-456 - Abstract
Abstract 2′,4′‐Dihydroxy‐6′‐methoxy‐3′,5′‐dimethylchalcone (DMC) is a typical and abundant chalcone compound from the buds of Cleistocalyx operculatus, which is well‐known for its edible and medicinal qualities. In this study, DMC showed effective cell cycle arrest at G2/M on MDA‐MB‐231 cells, though dual impacts, including the inhibition of microtubule polymerization through binding to β‐tubulin and the stimulation of reactive oxygen species (ROS) production by inhibiting catalase activity. The increased ROS level inhibited PI3K/Akt/mTOR pathway and further suppressed the expression level of Cdc2, Cdc25C, and Cyclin B1, alongside stimulated the expression level of p21 and p27. Above 29.5% MDA‐MB‐231 cells were arrested at G2/M phase, subsequently undergoing apoptosis due to heightened levels of apoptosis‐related proteins Bax and caspase 3. In summary, this study demonstrated that DMC concomitantly plays dual roles in apoptotic inducing by inhibiting the ROS consumption and microtubules formation in triple‐negative breast cancer cells.
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- 2024
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68. Exhaled VOC detection in lung cancer screening: a comprehensive meta-analysis
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Xianzhe Fan, Ran Zhong, Hengrui Liang, Qiu Zhong, Hongtai Huang, Juan He, Yang Chen, Zixun Wang, Songlin Xie, Yu Jiang, Yuechun Lin, Sitong Chen, Wenhua Liang, and Jianxing He
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Volatile organic compounds ,Lung cancer ,Exhaled ,Diagnostic accuracy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Lung cancer (LC), characterized by high incidence and mortality rates, presents a significant challenge in oncology. Despite advancements in treatments, early detection remains crucial for improving patient outcomes. The accuracy of screening for LC by detecting volatile organic compounds (VOCs) in exhaled breath remains to be determined. Methods Our systematic review, following PRISMA guidelines and analyzing data from 25 studies up to October 1, 2023, evaluates the effectiveness of different techniques in detecting VOCs. We registered the review protocol with PROSPERO and performed a systematic search in PubMed, EMBASE and Web of Science. Reviewers screened the studies’ titles/abstracts and full texts, and used QUADAS-2 tool for quality assessment. Then performed meta-analysis by adopting a bivariate model for sensitivity and specificity. Results This study explores the potential of VOCs in exhaled breath as biomarkers for LC screening, offering a non-invasive alternative to traditional methods. In all studies, exhaled VOCs discriminated LC from controls. The meta-analysis indicates an integrated sensitivity and specificity of 85% and 86%, respectively, with an AUC of 0.93 for VOC detection. We also conducted a systematic analysis of the source of the substance with the highest frequency of occurrence in the tested compounds. Despite the promising results, variability in study quality and methodological challenges highlight the need for further research. Conclusion This review emphasizes the potential of VOC analysis as a cost-effective, non-invasive screening tool for early LC detection, which could significantly improve patient management and survival rates.
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- 2024
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69. Additive effect of admission hyperglycemia on left ventricular stiffness in patients following acute myocardial infarction verified by CMR tissue tracking
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Pei-Lun Han, Kang Li, Yu Jiang, Yue Gao, Ying-Kun Guo, Zhi-Gang Yang, and Yuan Li
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Stress hyperglycemia ,Acute myocardial infarction ,Left ventricle ,Strain ,Magnetic resonance imaging ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Stress hyperglycemia occurs frequently in patients following acute myocardial infarction (AMI) and may aggravate myocardial stiffness, but relevant evidence is still lacking. Accordingly, this study aimed to examine the impact of admission stress hyperglycemia on left ventricular (LV) myocardial deformation in patients following AMI. Methods A total of 171 patients with first AMI (96 with normoglycemia and 75 with hyperglycemia) underwent cardiac magnetic resonance (CMR) examination were included. AMI patients were classified according to admission blood glucose level (aBGL): < 7.8 mmol/L (n = 96), 7.8–11.1 mmol/L (n = 41) and ≥ 11.1 mmol/L (n = 34). LV strains, including global radial/circumferential/longitudinal peak strain (PS)/peak systolic strain rate (PSSR)/peak diastolic strain rate (PDSR), were measured and compared between groups. Further, subgroup analyses were separately conducted for AMI patients with and without diabetes. Multivariate analysis was employed to assess the independent association between aBGL and LV global PS in AMI patients. Results LV global PS, PSSR and PDSR were decreased in radial, circumferential and longitudinal directions in hyperglycemic AMI patients compared with normoglycemic AMI patients (all P
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- 2024
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70. Novel radiopaque ethanol injection: physicochemical properties, animal experiments, and clinical application in vascular malformations
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Yu-Chen Shen, De-Ming Wang, Xi-Tao Yang, Zhen-Feng Wang, Ming-Zhe Wen, Yi-Feng Han, Lian-Zhou Zheng, Ruo-Yu Di, Chun-Yu Jiang, Jing-Bing Wang, Jian-Xiong You, Li-Ming Zhang, Li-Xin Su, and Xin-Dong Fan
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Vascular malformation ,Ethanol ,Sclerotherapy ,Radiopacity ,Iopromide ,Radiopaque ethanol injection ,Medicine (General) ,R5-920 ,Military Science - Abstract
Abstract Background Despite the efficacy of absolute ethanol (EtOH), its radiolucency introduces several risks in interventional therapy for treating vascular malformations. This study aims to develop a novel radiopaque ethanol injection (REI) to address this issue. Methods Iopromide is mixed with ethanol to achieve radiopacity and improve the physicochemical properties of the solution. Overall, 82 male New Zealand white rabbits are selected for in vivo radiopacity testing, peripheral vein sclerosis [animals were divided into the following 5 groups (n = 6): negative control (NC, saline, 0.250 ml/kg), positive control (EtOH, 0.250 ml/kg), low-dose REI (L-D REI, 0.125 ml/kg), moderate-dose REI (M-D REI, 0.250 ml/kg), and high-dose REI (H-D REI 0.375 ml/kg)], pharmacokinetic analyses (the blood sample was harvested before injection, 5 min, 10 min, 20 min, 40 min, 1 h, 2 h, 4 h, and 8 h after injection in peripheral vein sclerosis experiment), peripheral artery embolization [animals were divided into the following 5 groups (n = 3): NC (saline, 0.250 ml/kg), positive control (EtOH, 0.250 ml/kg), L-D REI (0.125 ml/kg), M-D REI (0.250 ml/kg), and H-D REI (0.375 ml/kg)], kidney transcatheter arterial embolization [animals were divided into the following 4 groups (n = 3): positive control (EtOH, 0.250 ml/kg), L-D REI (0.125 ml/kg), M-D REI (0.250 ml/kg), and H-D REI (0.375 ml/kg); each healthy kidney was injected with saline as negative control], and biosafety evaluations [animals were divided into the following 5 groups (n = 3): NC (0.250 ml/kg), high-dose EtOH (0.375 ml/kg), L-D REI (0.125 ml/kg), M-D REI (0.250 ml/kg), and H-D REI (0.375 ml/kg)]. Then, a prospective cohort study involving 6 patients with peripheral venous malformations (VMs) is performed to explore the clinical safety and effectiveness of REI. From Jun 1, 2023 to August 31, 2023, 6 patients [age: (33.3 ± 17.2) years] with lingual VMs received sclerotherapy of REI and 2-month follow-up. Adverse events and serious adverse events were evaluated, whereas the efficacy of REI was determined by both the traceability of the REI under DSA throughout the entire injection and the therapeutic effect 2 months after a single injection. Results The REI contains 81.4% ethanol (v/v) and 111.3 mg/ml iodine, which can be traced throughout the injection in the animals and patients. The REI also exerts a similar effect as EtOH on peripheral venous sclerosis, peripheral arterial embolization, and renal embolization. Furthermore, the REI can be metabolized at a similar rate compared to EtOH and Ultravist® and did not cause injury to the animals’ heart, liver, spleen, lungs, kidneys and brain. No REI-related adverse effects have occurred during sclerotherapy of VMs, and 4/6 patients (66.7%) have achieved complete response at follow-up. Conclusion In conclusion, REI is safe, exerts therapeutic effects, and compensates for the radiolucency of EtOH in treating VMs. Trial registration The clinical trial was registered as No. ChiCTR2300071751 on May 24 2023.
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- 2024
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71. Risk factors for subsequent fractures in hip fracture patients: a nested case-control study
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Mi Song, Yilin Wang, Yu Jiang, Hongying Pi, Houchen Lyu, and Yuan Gao
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Subsequent fracture ,Hip fracture ,Risk factors ,Osteoporosis ,Anti-osteoporosis medications ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background The risk factors for subsequent fractures following an initial hip fracture are not entirely understood. This study examined the clinical characteristics of hip fracture patients to identify potential risk factors associated with a higher risk of experiencing subsequent fractures. Methods We conducted a nested case-control study using data from the Chinese PLA General Hospital Hip Fracture Cohort between January 2008 and March 2022. The cases were individuals who experienced subsequent fractures following an initial hip fracture. Each case was matched with up to 2 controls who did not develop subsequent fractures. Important clinical factors were compared across groups, including traditional fracture risk factors and potential risk factors (e.g., comorbidities, falls risk, physical impairment, calcium or vitamin D use, and anti-osteoporosis medications). Conditional logistic regression analyses were used to evaluate the impact of these clinical features as potential risk factors for subsequent fractures. Results A total of 96 individuals who suffered from subsequent fractures were matched with 176 controls. The median time between the initial hip fracture and the subsequent fracture was 2.1 years. The overall proportion of patients receiving anti-osteoporosis treatment after initial hip fracture was 25.7%. In the multivariable regression analysis, living in a care facility (OR = 3.78, 95%CI: 1.53–9.34), longer hospital stays (OR = 1.05, 95%CI: 1.00–1.11), and falls after discharge (OR = 7.58, 95%CI: 3.37–17.04) were associated with higher odds of subsequent fractures. Conclusions This study showed that living in a care facility, longer hospital stays, and falls after discharge may be independent risk factors for repeat fractures following an initial hip fracture. These findings could be used to identify and manage patients at high risk of subsequent fractures.
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- 2024
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72. An improved calculation of the $$D_{(s)}^*D_{(s)}V$$ D ( s ) ∗ D ( s ) V and $$B_{(s)}^*B_{(s)}V$$ B ( s ) ∗ B ( s ) V couplings from light-cone sum rules
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Su-Ping Jin and Hua-Yu Jiang
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Astrophysics ,QB460-466 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract We present an improved calculation of the $$D_{(s)}^*D_{(s)}V$$ D ( s ) ∗ D ( s ) V and $$B_{(s)}^*B_{(s)}V$$ B ( s ) ∗ B ( s ) V coupling constants, where V denotes $$\rho $$ ρ , $$K^*$$ K ∗ , $$\omega $$ ω , and $$\phi $$ ϕ mesons. These couplings govern the long-distance quantum chromodynamics (QCD) in interactions between heavy pseudo-scalar/vector mesons and light vector mesons. Our analysis is conducted within the framework of QCD light-cone sum rules (LCSRs) by utilizing the light-cone distribution amplitudes (LCDAs) of light vector mesons. By systematically incorporating the subleading power corrections and higher-twist contributions at the leading order (LO) and including the next-to-leading order (NLO) corrections at leading power, we achieve enhanced accuracy in the light-cone operator product expansion (OPE) for the underlying correlation function. In assessing the reliability of the established LCSRs, we consider uncertainties arising from the choice of the quark–hadron duality region in the double dispersion relation. Building upon these improvements, we accomplish an optimized computation and analysis for the strong coupling constants $$g_{H^*HV}$$ g H ∗ H V which are used to extract the effective coupling $$\lambda $$ λ in the heavy meson chiral perturbation theory (HM $$\chi $$ χ PT). Furthermore, we investigate the SU(3) flavor symmetry-breaking effects in detail and compare our sum rule calculations with previous studies in an exploratory way.
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- 2024
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73. Whole-genome sequencing reveals genomic diversity and selection signatures in Xia’nan cattle
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Xingya Song, Zhi Yao, Zijing Zhang, Shijie Lyu, Ningbo Chen, Xingshan Qi, Xian Liu, Weidong Ma, Wusheng Wang, Chuzhao Lei, Yu Jiang, Eryao Wang, and Yongzhen Huang
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Xia’nan cattle ,Genetic diversity ,Population structure ,Genetic signatures ,Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Abstract
Abstract Background The crossbreeding of specialized beef cattle breeds with Chinese indigenous cattle is a common method of genetic improvement. Xia’nan cattle, a crossbreed of Charolais and Nanyang cattle, is China’s first specialized beef cattle breed with independent intellectual property rights. After more than two decades of selective breeding, Xia’nan cattle exhibit a robust physique, good environmental adaptability, good tolerance to coarse feed, and high meat production rates. This study analyzed the population genetic structure, genetic diversity, and genomic variations of Xia’nan cattle using whole-genome sequencing data from 30 Xia’nan cattle and 178 published cattle genomic data. Result The ancestry estimating composition analysis showed that the ancestry proportions for Xia’nan cattle were mainly Charolais with a small amount of Nanyang cattle. Through the genetic diversity studies (nucleotide diversity and linkage disequilibrium decay), we found that the genomic diversity of Xia’nan cattle is higher than that of specialized beef cattle breeds in Europe but lower than that of Chinese native cattle. Then, we used four methods to detect genome candidate regions influencing the excellent traits of Xia’nan cattle. Among the detected results, 42 genes (θπ and CLR) and 131 genes (F ST and XP-EHH) were detected by two different detection strategies. In addition, we found a region in BTA8 with strong selection signals. Finally, we conducted functional annotation on the detected genes and found that these genes may influence body development (NR6A1), meat quality traits (MCCC1), growth traits (WSCD1, TMEM68, MFN1, NCKAP5), and immunity (IL11RA, CNTFR, CCL27, SLAMF1, SLAMF7, NAA35, and GOLM1). Conclusion We elucidated the genomic features and population structure of Xia’nan cattle and detected some selection signals in genomic regions potentially associated with crucial economic traits in Xia’nan cattle. This research provided a basis for further breeding improvements in Xia’nan cattle and served as a reference for genetic enhancements in other crossbreed cattle.
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- 2024
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74. Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma
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Hua-yang Fan, Ming-da Zhao, Hong-jie Jiang, Zhen-wei Yu, Yu-jiang Fan, Xin-hua Liang, Ya-ling Tang, and Yong Sun
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Oral squamous cell carcinoma ,CircRNA ,MiRNA sponge ,Antagomir ,MiRNA delivery ,Cisplatin-based nanoparticles ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Circular RNAs (circRNAs) are ideal biomarkers of oral squamous cell carcinoma (OSCC) because of their highly stable closed-loop structure, and they can act as microRNA (miRNA) sponges to regulate OSCC progression. By analyzing clinical samples, we identified circCPNE1, a dysregulated circRNA in OSCC, and its expression level was negatively correlated with the clinical stage of OSCC patients. Gain-of-function assays revealed the tumor-suppressive effect of circCPNE1, which was then identified as a miR-330-3p sponge. MiR-330-3p was recognized as a tumor promoter in multiple studies, consistent with our finding that it could promote the proliferation, migration, and invasion of OSCC cells. These results indicated that selective inhibition of miR-330-3p could be an effective strategy to inhibit OSCC progression. Therefore, we designed cationic polylysine-cisplatin prodrugs to deliver antagomiR-330-3p (a miRNA inhibitory analog) via electrostatic interactions to form PP@miR nanoparticles (NPs). Paratumoral administration results revealed that PP@miR NPs effectively inhibited subcutaneous tumor progression and achieved partial tumor elimination (2/5), which confirmed the critical role of miR-330-3p in OSCC development. These findings provide a new perspective for the development of OSCC treatments.
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- 2024
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75. Selectivin: A nematicide from parasitic nematodes-specifically activated chemical
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En-Yu Jiang, Otgonpurev Sukhbaatar, Ming-Zhi Zhang, Wei-Hua Zhang, and Yu-Cheng Gu
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Plant-parasitic nematodes (PPNs) ,Nematode control ,CYPs ,Emb-8 ,CYP4731A3 ,Agriculture (General) ,S1-972 ,Biochemistry ,QD415-436 ,Chemistry ,QD1-999 - Abstract
The latest study published in Nature by Andrew R. Burns, Peter J. Roy and co-authors is highlighted in this paper, they investigated a series of novel nematicidal compounds, including Selectivin-A and Selectivin-E, and explored their mechanism of action. Experiments have displayed that the Selectivin compound is inactive to human cells, fish, fungi, insects and even beneficial nematodes. In the exploration of its mechanism of action, it was found that the mechanism of action of Selectivin is different with those of commercial nematocides: Selectivin needs to be activated by biotin produced by nematodes, after that they can be transformed into compounds with high nematicidal activity. This proves that the family of Selectivin compounds has the advantages of high selectivity and environmental friendliness, and their mechanism of action is completely new, proposing a completely new path for the development of new nematicides.
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- 2024
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76. Correlation between Bcl-2 Expression and the Efficacy of Bcl-2 Inhibitors in Patients with Myelodysplastic Syndromes
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WU Jiafei, WANG Jun, WANG Yijing, ZHENG Boyue, WANG Yu, JIANG Chuanyan, DONG Dandan, LI Hui
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myelodysplastic syndromes ,bcl-2 ,venetoclax ,prognosis ,intervention effect ,Medicine - Abstract
Background The heterogeneity of myelodysplastic syndromes (MDS) is strong, with poor efficacy of existing therapeutic regimens and large individual differences in patient prognosis. B-cell lymphomato-2 (Bcl-2) protein is highly expressed in patients with myeloid tumors, which has been proved by previous to be associated with disease progression, chemotherapy resistance, and shortened overall survival. The Bcl-2 inhibitor Veneckla (VEN) is approved for elderly patients with newly diagnosed acute myeloid leukemia (AML) who are not eligible for intensive therapy, and there is less data on its use in MDS patients. The difference in Bcl-2 expression in MDS patients and its correlation with the efficacy and prognosis of VEN therapy haven't been reported. Objective To analyse the expression of Bcl-2 protein in MDS patients and assess its correlation with the efficacy and prognosis of VEN treatment. Methods The clinical data of 71 patients with MDS admitted to Sichuan Academy of Medical Sciences·Sichuan Provincial People's Hospital from July 2018 to December 2022 were retrospectively analyzed. Baseline data of patients including gender, age, blood routine, blood biochemistry, bone marrow hemocytology, flow cytometry, chromosome karyotype, myeloid gene mutation, fusion gene mutation and MDS-EB typing were collected. The expression of Bcl-2 protein was detected by immunohistochemical staining. According to the modified International Prognostic Score System (IPSS-R), the patients were divided into 5 risk levels of very low risk (0 case), low risk (1 case), medium risk (7 cases), high risk (40 cases) and very high risk (23 cases). Patients with bone marrow Bcl-2 positivity≥10% were defined as Bcl-2 positive and0.05) . Conclusion Bcl-2 protein contributes to MDS fusion gene mutation and myeloid gene mutation; Bcl-2 positive expression was not associated with the survival of MDS patients. There was no difference in survival rate between Bcl-2 positive and Bcl-2 negative patients who received the VA combination regimen.
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- 2024
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77. The interaction of occupational stress and job burnout on depressive symptoms in railway workers in Fuzhou city
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Shuangjie Yu, Min Zhao, Ye Li, Can Liu, Youjuan Fu, Yu Jiang, and Suzhen Guan
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Rail workers ,Job burnout ,Occupational stress ,Depressive symptoms ,Interaction effect ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background To explore the relationship between occupational stress, burnout and depressive symptoms among railroad workers in Fuzhou, and to analyze the interaction of burnout and occupational stress on depressive symptoms. Methods In this study, 861 railway employees of Fuzhou railway bureau were randomly selected from January to April, 2022. Occupational stress inventory revised edition (OSI-R), China job burnout inventory (CMBI) and Symptom Checklist-90 (SCL-90) were used to investigate the occupational stress, job burnout and depressive symptoms of railway workers. Interactions associated with depressive symptoms were assessed by linear hierarchical regression analysis and SPSS macros (PROCESS). Results Occupational stress, job burnout and depressive symptoms accounted for 50.58%, 93.47%, and 11.19% of the study population, respectively. There were intergroup differences between age, marriage status, and length of service (P
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- 2024
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78. Air pollution, life’s essential 8, and risk of severe non-alcoholic fatty liver disease among individuals with type 2 diabetes
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Ruxianguli Aimuzi, Zhilan Xie, Yimin Qu, and Yu Jiang
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Non-alcoholic fatty liver disease (NAFLD) ,Air pollution ,Life’s Essential 8 (LE8) ,Type 2 diabetes (T2D) ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The impacts of long-term exposure to air pollution on the risk of subsequent non-alcoholic fatty liver disease (NAFLD) among participants with type 2 diabetes (T2D) is ambiguous. The modifying role of Life’s Essential 8 (LE8) remains unknown. Methods This study included 23,129 participants with T2D at baseline from the UK Biobank. Annual means of nitrogen dioxide (NO2), nitrogen oxides (NOX), and particulate matter (PM2.5, PM2.5–10, PM10) were estimated using the land-use regression model for each participant. The associations between exposure to air pollution and the risk of severe NAFLD were evaluated using Cox proportional hazard models. The effect modification of LE8 was assessed through stratified analyses. Results During a median 13.6 years of follow-up, a total of 1,123 severe NAFLD cases occurred. After fully adjusting for potential covariates, higher levels of PM2.5 (hazard ratio [HR] = 1.12, 95%CI:1.02, 1.23 per interquartile range [IQR] increment), NO2 (HR = 1.15, 95%CI:1.04, 1.27), and NOX (HR = 1.08, 95%CI:1.01, 1.17) were associated with an elevated risk of severe NAFLD. In addition, LE8 score was negatively associated with the risk of NAFLD (HR = 0.97, 95% CI: 0.97, 0.98 per point increment). Compared with those who had low air pollution and high LE8, participants with a high air pollution exposure and low LE8 had a significantly higher risk of severe NAFLD. Conclusions Our findings suggest that long-term exposure to air pollution was associated with an elevated risk of severe NAFLD among participants with T2D. A lower LE8 may increase the adverse impacts of air pollution on NAFLD.
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- 2024
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79. Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool
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Haidi Huang, Yu Jiang, Jiangying Liu, Dan Luo, Jianghong Yuan, Rongzi Mu, Xiang Yu, Donglei Sun, Jihong Lin, Qiyue Chen, Xinjing Li, Ming Jiang, Jianming Xu, Bo Chu, Chengqian Yin, Lei Zhang, Youqiong Ye, Bo Cao, Qiong Wang, and Yongchun Zhang
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Science - Abstract
Abstract Basal progenitor cells are crucial for maintaining foregut (the esophagus and forestomach) homeostasis. When their function is dysregulated, it can promote inflammation and tumorigenesis. However, the mechanisms underlying these processes remain largely unclear. Here, we employ genetic mouse models to reveal that Jag1/2 regulate esophageal homeostasis and foregut tumorigenesis by modulating the function of basal progenitor cells. Deletion of Jag1/2 in mice disrupts esophageal and forestomach epithelial homeostasis. Mechanistically, Jag1/2 deficiency impairs activation of Notch signaling, leading to reduced squamous epithelial differentiation and expansion of basal progenitor cells. Moreover, Jag1/2 deficiency exacerbates the deoxycholic acid (DCA)-induced squamous epithelial injury and accelerates the initiation of squamous cell carcinoma (SCC) in the forestomach. Importantly, expression levels of JAG1/2 are lower in the early stages of human esophageal squamous cell carcinoma (ESCC) carcinogenesis. Collectively, our study demonstrates that Jag1/2 are important for maintaining esophageal and forestomach homeostasis and the onset of foregut SCC.
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- 2024
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80. The current clinical landscape of neonatal respiratory failure in Jiangsu Province of China: patient demographics, NICU treatment interventions, and patient outcomes
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Na Wang, Ke-Yu Lu, Shan-Yu Jiang, Hong-Wei Wu, Rui Cheng, Zhao-Jun Pan, Huai-Yan Wang, and on behalf of the Jiangsu Provincial Collaborative Study Group for Neonatal Respiratory Diseases
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Neonatology ,Respiratory failure ,Morbidity ,Mortality ,Neonatal intensive care ,Pediatrics ,RJ1-570 - Abstract
Abstract Introduction Neonatal respiratory failure (NRF) is a serious condition that often has high mortality and morbidity, effective interventions can be delivered in the future by identifying the risk factors associated with morbidity and mortality. However, recent advances in respiratory support have improved neonatal intensive care units (NICUs) care in China. We aimed to provide an updated review of the clinical profile and outcomes of NRF in the Jiangsu province. Methods Infants treated for NRF in the NICUs of 28 hospitals between March 2019 and March 2022 were retrospectively reviewed. Data collected included baseline perinatal and neonatal parameters, NICU admission- and treatment-related data, and patient outcomes in terms of mortality, major morbidity, and survival without major morbidities. Results A total of 5548 infants with NRF were included in the study. The most common primary respiratory disorder was respiratory distress syndrome (78.5%). NRF was managed with non-invasive and invasive respiratory support in 59.8% and 14.5% of patients, respectively. The application rate of surfactant therapy was 38.5%, while that of neonatal extracorporeal membrane oxygenation therapy was 0.2%. Mortality and major morbidity rates of 8.5% and 23.2% were observed, respectively. Congenital anomalies, hypoxic-ischemic encephalopathy, invasive respiratory support only and inhaled nitric oxide therapy were found to be significantly associated with the risk of death. Among surviving infants born at < 32 weeks of gestation or with a birth weight < 1500 g, caffeine therapy and repeat mechanical ventilation were demonstrated to significantly associate with increased major morbidity risk. Conclusion Our study demonstrates the current clinical landscape of infants with NRF treated in the NICU, and, by proxy, highlights the ongoing advancements in the field of perinatal and neonatal intensive care in China.
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- 2024
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81. Study on the differential hepatotoxicity of raw polygonum multiflorum and polygonum multiflorum praeparata and its mechanism
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Chaowen Huang, Yu Jiang, Qing Bao, Lu Wang, Lin Tang, Yanjuan Liu, and Lei Yang
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Polygonum multiflorum ,Hepatotoxicity ,Raw polygonum multiflorum ,Polygonum multiflorum praeparata ,Ferroptosis ,Other systems of medicine ,RZ201-999 - Abstract
Abstract Background Polygonum multiflorum (PM), a widely used traditional Chinese medicine herb, is divided into two forms, namely raw polygonum multiflorum (RPM) and polygonum multiflorum praeparata (PMP), according to the processing procedure. Emerging data has revealed the differential hepatotoxicity of RPM and PMP, however, its potential mechanism is still unclear. Methods In our study, we investigated the differential hepatotoxicity of RPM and PMP exerted in C57BL/6 mice. First, sera were collected for biochemical analysis and HE staining was applied to examine the morphological alternation of the liver. Then we treated L02 cells with 5 mg / mL of RPM or PMP. The CCK8 and EdU assays were utilized to observe the viability and proliferation of L02 cells. RNA sequencing was performed to explore the expression profile of L02 cells. Western blotting was performed to detect the expression level of ferroptosis-related protein. Flow cytometry was used to evaluate ROS accumulation. Results In our study, a significant elevation in serum ALT, AST and TBIL levels was investigated in the RMP group, while no significant differences were observed in the PMP group, compared to that of the CON group. HE staining showed punctate necrosis, inflammatory cell infiltration and structural destruction can be observed in the RPM group, which can be significantly attenuated after processing. In addition, we also found RPM could decrease the viability and proliferation capacity of L02 cells, which can be reversed by ferroptosis inhibitor. RNA sequencing data revealed the adverse effect of PM exerted on the liver is closely associated with ferroptosis. Western blotting assay uncovered the protein level of GPX4, HO-1 and FTL was sharply decreased, while the ROS content was dramatically elevated in L02 cells treated with RPM, which can be partially restored after processing. Conclusions The hepatotoxicity induced by RPM was significantly lower than the PMP, and its potential mechanism is associated with ferroptosis.
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- 2024
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82. Highly robust supramolecular polymer networks crosslinked by a tiny amount of metallacycles
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Lang He, Yu Jiang, Jialin Wei, Zibin Zhang, Tao Hong, Zhiqiang Ren, Jianying Huang, Feihe Huang, Peter J. Stang, and Shijun Li
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Science - Abstract
Abstract Supramolecular polymeric materials have exhibited attractive features such as self-healing, reversibility, and stimuli-responsiveness. However, on account of the weak bonding nature of most noncovalent interactions, it remains a great challenge to construct supramolecular polymeric materials with high robustness. Moreover, high usage of supramolecular units is usually necessary to promote the formation of robust supramolecular polymeric materials, which restrains their applications. Herein, we describe the construction of highly robust supramolecular polymer networks by using only a tiny amount of metallacycles as the supramolecular crosslinkers. A norbornene ring-opening metathesis copolymer with a 120° dipyridine ligand is prepared and self-assembled with a 60° or 120° Pt(II) acceptor to fabricate the metallacycle-crosslinked polymer networks. With only 0.28 mol% or less pendant dipyridine units to form the metallacycle crosslinkers, the mechanical properties of the polymers are significantly enhanced. The tensile strengths, Young’s moduli, and toughness of the reinforced polymers reach up to more than 20 MPa, 600 MPa, and 150 MJ/m3, respectively. Controllable destruction and reconstruction of the metallacycle-crosslinked polymer networks are further demonstrated by the sequential addition of tetrabutylammonium bromide and silver triflate, indicative of good stimuli-responsiveness of the networks. These remarkable performances are attributed to the thermodynamically stable, but dynamic metallacycle-based supramolecular coordination complexes that offer strong linkages with good adaptive characteristics.
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- 2024
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83. Maximising CP Violation in naturally aligned Two-Higgs Doublet Models
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Darvishi, Neda, Pilaftsis, Apostolos, and Yu, Jiang-Hao
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- 2024
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84. Complete UV resonances of the dimension-8 SMEFT operators
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Li, Hao-Lin, Ni, Yu-Han, Xiao, Ming-Lei, and Yu, Jiang-Hao
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- 2024
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85. Complete EFT operator bases for dark matter and weakly-interacting light particle
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Song, Huayang, Sun, Hao, and Yu, Jiang-Hao
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- 2024
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86. Positivity from J-Basis operators in the standard model effective Field Theory
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Yang, Chengjie, Ren, Zhe, and Yu, Jiang-Hao
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- 2024
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87. POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase
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Peng, Yanmei, Zheng, Wenbo, Chen, Yuehong, Lei, Xuetao, Yang, Zhijing, Yang, Yuxuan, Liang, Weiqi, Sun, Kai, Li, Guoxin, and Yu, Jiang
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- 2024
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88. Multi-step phase transition and gravitational wave from general $\mathbb{Z}_2$ scalar extensions
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Cao, Qing-Hong, Hashino, Katsuya, Li, Xu-Xiang, and Yu, Jiang-Hao
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High Energy Physics - Phenomenology - Abstract
Multi-step phase transition provides a paradigm in which a broken symmetry during phase transition can be restored, enriching the phenomena of both dark matter and baryon asymmetry. We study the dynamics of the multi-step phase transition in the standard model extension with additional isospin $N$-plet scalar field $\Phi_2$ under a discrete $\mathbb{Z}_2$ symmetry. We find that the multi-step phase transition could be triggered if there is a moderately large coupling between the Higgs and the $\Phi_2$ and this coupling is required to be larger as the mass of the $\Phi_2$ and/or isospin increase. The first-order phase transition at the first (second) step can be realized by the thermal loop (tree-level barrier) effects. Thus it is more likely that a detectable spectrum of gravitational waves can be produced at the second step of the phase transition., Comment: 40 pages, 12 figures
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- 2022
89. Exploring Immersive Interpersonal Communication via AR
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Lee, Kyungjun, Li, Hong, Wellyanto, Muhammad Rizky, Tham, Yu Jiang, Monroy-Hernández, Andrés, Liu, Fannie, Smith, Brian A., and Vaish, Rajan
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Computer Science - Human-Computer Interaction - Abstract
A central challenge of social computing research is to enable people to communicate expressively with each other remotely. Augmented reality has great promise for expressive communication since it enables communication beyond texts and photos and towards immersive experiences rendered in recipients' physical environments. Little research, however, has explored AR's potential for everyday interpersonal communication. In this work, we prototype an AR messaging system, ARwand, to understand people's behaviors and perceptions around communicating with friends via AR messaging. We present our findings under four themes observed from a user study with 24 participants, including the types of immersive messages people choose to send to each other, which factors contribute to a sense of immersiveness, and what concerns arise over this new form of messaging. We discuss important implications of our findings on the design of future immersive communication systems., Comment: Will be published in PACM HCI, CSCW1, April 2023 issue
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- 2022
90. Hilbert Series and Operator Counting on the Higgs Effective Field Theory
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Sun, Hao, Wang, Yi-Ning, and Yu, Jiang-Hao
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High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
We present a systematic procedure for determining the Hilbert series that counts the number of independent operators in the Higgs effective field theory. After removing the redundancies from equation-of-motion and integration-by-part, we provide an algorithm of treating the redundancy from the operators involving in spurion fields parametrizing the custodial symmetry breaking. Furthermore, we utilize the outer automorphism of the Lorentz and internal symmetries to separate operators with different CP properties. With these new implements, the Hilbert series up to chiral dimension 10 are obtained, and CP-even and CP-odd operators can be further divided. Extensions to all orders are straightforward., Comment: 28 pages, 3 figures, 6 tables
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- 2022
91. Custodial Symmetry Violation in Scalar Extensions of the Standard Model
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Song, Huayang, Wan, Xia, and Yu, Jiang-Hao
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High Energy Physics - Phenomenology - Abstract
The new measurement of the W boson mass from the CDF collaboration shows a significant tension with the Standard Model prediction, which evidences violation of custodial symmetry in the scalar sector. We study the scalar extensions of the Standard Model, which can be categorized into two classes, scalar sector with custodial symmetry (Georgi-Machacek model and its generalizations) and scalar sector without custodial symmetry, and explore how these extensions fit to the electroweak precision data and the CDF new $m_W$ . The favored oblique parameters are coming from either the large mass splitting in the multiplet via the loop contribution or the large vacuum expectation value which breaks custodial symmetry at the tree level. In particular, we find that $\mathcal{O}(100)$ GeV new particles are allowed in the scalar extension scenarios., Comment: 24 pages, 4 figures
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- 2022
92. A Complete Set of the Dimension-8 Green's Basis Operators in the Standard Model Effective Field Theory
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Ren, Zhe and Yu, Jiang-Hao
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High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
We present a complete and independent off-shell Green's basis of the dimension 8 operators in the Standard Model effective field theory (SMEFT). We propose an off-shell amplitude formalism such that this new kind of amplitudes has a one-to-one correspondence to general operators carrying all kinds of redundancies. The advantage of such formalism is that all kinds of redundancies can be formulated explicitly in terms of the off-shell spinors and thus be removed systematically from the exhaustive list of the general off-shell amplitudes. Following such procedure, redundant operators can be reduced to the ones with the only redundancy from the equation of motion kept, the Green's basis. We find there are (993+1649) independent (on-shell + off-shell) operators for one generation of fermions and (44807+66197) ones for three generations at the dimension 8. This systematic method can be applied to obtain the Green's basis at any mass dimension for general EFTs., Comment: 65 pages, 4 tables, updated references and acknowledgements
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- 2022
93. Complete NNLO Operator Bases in Higgs Effective Field Theory
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Sun, Hao, Xiao, Ming-Lei, and Yu, Jiang-Hao
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High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
For the first time, we list the complete and independent set of operators at the next-to-next-to-leading order (NNLO) in the Higgs effective field theory (HEFT), also named as the electroweak chiral Lagrangian with the light Higgs boson. The Young tensor technique utilized in this work guarantees the completeness and independence of the on-shell amplitude basis while the Adler zero condition imposes non-linear symmetry on the Nambu-Goldstone bosons that play the central role in the chiral Lagrangian. The spurion fields are incorporated into the gauge structure of operators following the Littlewood-Richardson rule to accommodate custodial symmetry breaking. We enumerate 11506 (1927574) NNLO operators for one (three) flavor of fermions for the electroweak chiral Lagrangian with the light Higgs. Below the electroweak symmetry breaking scale, the dimension-8 standard model effective field theory (SMEFT) operators could be matched to these HEFT operators at both the NLO and NNLO orders., Comment: 419 pages, 3 tables
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- 2022
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94. Investigating Higgs self-interaction through di-Higgs plus jet production
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Chai, Kangyu, Yu, Jiang-Hao, and Zhang, Hao
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment ,High Energy Physics - Theory - Abstract
The Higgs self coupling measurement is quite essential for determining the shape of the Higgs potential and nature of the Higgs boson. We propose the di-Higgs plus jet final states at hadron colliders to increase the discovery sensitivity of the Higgs self coupling at the low invariant mass region. Our simulation indicates that the allowed region of the Higgs self coupling would be further narrowed from $[-1.5,6.7]$ from the most recent ATLAS report down to $[0.5, 1.7]$. Furthermore, we find negative Higgs self couplings would be disfavored beyond $2\sigma$ confidence level at a future 100TeV collider with the help of this signal., Comment: 9 pages, 5 figures
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- 2022
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95. Comparative study of the antibacterial effects of wound secretions of different cultivars of Chinese fir
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Yu Jiang, Yalin Zeng, Jianing Zhu, Linjun Sun, Pengfei Wu, Ming Li, and Xiangqing Ma
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Chinese fir ,Antibacterial effect ,Wound secretions ,Cultivars ,Bacterial minimum inhibitory concentration ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Background The bark of Chinese fir (Cunninghamia lanceolata), the largest afforestation tree species in the forest areas of southern China, is susceptible to injuries and bites from small animals. The population of small animals has recently increased owing to improvements in the ecological environment across various forested areas, thus increasing the incidence of injuries in the bark of Chinese fir. Following such injuries, the bark secretes light yellow or milky white secretions, the function of which remains unclear. The present study aimed to reveal the antibacterial effect of exudates of different Chinese fir cultivars on five bacterial species. Methods The research involved three-year-old plantations of Taxus chinensis var. koraiensis and Yangkou3 and three-year-old container plantations of Taxus chinensis var. pendula, Yang 061, and Yang 020. The antibacterial effects of exudates were analyzed using the filter paper diffusion method. The minimum inhibitory concentration for each secretion and the bacterial inhibition zone were determined. Results The exudates of the different Chinese fir bark exhibited notable antibacterial effects on Bacillus subtilis, Salmonella paratyphi B, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus. However, the extent of these antibacterial effects varied among the different Chinese fir cultivars, as the minimum inhibitory concentrations (MICs) of the exudates against the five bacterial species varied. The mean MIC of Pseudomonas aeruginosa was lower potency, whereas that of Escherichia coli was the lowest. Notably, the antibacterial efficacy of the exudates was mainly influenced by the composition of the secretions rather than the number of secretions, with organic acid compounds and terpenoids potentially contributing to the antibacterial effects against E. coli and Bacillus subtilis, respectively. Conclusion This study demonstrates the antibacterial effect of wound secretion of different Chinese fir cultivars, highlighting their varying efficacy on different bacterial species. Moreover, the antibacterial ability of the exudates of the strains was mainly determined by the composition of the wound secretions, and there was no noticeable relationship with the number of wound secretions. The results of this study offers a theoretical basis for screen Chinese fir cultivars with high-disease-resistant.
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- 2024
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96. ALKBH5-mediated N6-methyladenosine modification of HO-1 mRNA regulates ferroptosis in cobalt-induced neurodegenerative damage
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Qianqian Su, Lingyan Wu, Chunyan Zheng, Xianqi Ji, Xinpei Lin, Yu Zhang, Fuli Zheng, Zhenkun Guo, Wenya Shao, Hong Hu, Jinfu Zhou, Yu Jiang, Ying Tang, Siying Wu, Michael Aschner, Huangyuan Li, and Guangxia Yu
- Subjects
Cobalt ,Ferroptosis ,Epigenetic hazard ,N6-methyladenosine demethylase ,Neurodegenerative damage ,Environmental sciences ,GE1-350 - Abstract
The utilization of Cobalt (Co) has surged due to it is critical role in renewable energy technologies and other high-tech applications. Concurrently, the potential health risks associated with Co exposure have raised concerns. Previous studies, including our own, have shown that Co can impair learn and memory functions as an epigenetic hazard, even at low concentrations. In this study, we explore the mechanisms of Co-induced ferroptosis in neurodegenerative damage both in vivo and in vitro, focusing on the epigenetic regulation by N6-methyladenosine (m6A) demethylase alkB homolog 5 (ALKBH5). We identify heme oxygenase-1 (HO-1) as a direct target gene of ALKBH5, playing a crucial role in mitigating Co-induced ferroptosis. ALKBH5 deficiency affects the post-transcriptional regulation of HO-1 through m6A modification, which in turn influences mRNA’s stability, intracellular distribution, and alternative splicing, thereby enhancing susceptibility to Co-induced ferroptosis. Additionally, we discuss the potential involvement of heterogeneous nuclear ribonucleoprotein M (hnRNPM) in regulating alternative splicing of HO-1 mRNA, potentially mediated by m6A modifications. This study provides new epigenetic insights into the post-transcriptional regulatory mechanisms involved in Co-induced ferroptosis and highlights the broader implications of environmental hazards in neurodegenerative damage.
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- 2024
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97. The application of extracellular vesicles in orthopedic diseases
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Yuexin Li, Haiyan Zhang, Yu Jiang, Jian Yang, Daozhang Cai, and Xiaochun Bai
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diagnosis ,drug delivery ,extracellular vesicles ,orthopedic diseases ,regeneration ,Medical technology ,R855-855.5 ,Biotechnology ,TP248.13-248.65 - Abstract
Abstract Orthopedic diseases, such as osteoarthritis and fractures, place a significant burden on individuals and healthcare systems worldwide. Extracellular vesicles (EVs), which are membrane‐derived particles, have emerged as a novel tool in the field of orthopedics. EVs play a crucial role in diagnosing, regenerating, and treating orthopedic diseases. In terms of diagnosis, EVs serve as potential biomarkers, carrying unique donor cell information and circulating effectively in bodily fluids. Specific biomolecules within EVs, including proteins, nucleic acids, and microRNAs, hold promise as biological markers for the early detection and monitoring of orthopedic diseases. EVs have shown significant potential in promoting bone and cartilage regeneration. They can enhance tissue regeneration by stimulating various stem cells to proliferate, migrate, and differentiate into mature chondrocytes and osteocytes. EVs can also target specific tissues, making them attractive candidates for drug delivery in orthopedic diseases. They can efficiently deliver therapeutic cargo, such as anti‐inflammatory agents and growth factors, to the affected sites, enhancing treatment efficacy while minimizing toxicity and adverse effects. In conclusion, EVs have significant potential in diagnosing, regenerating, and treating orthopedic diseases.
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- 2024
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98. Genome composition-based deep learning predicts oncogenic potential of HPVs
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Lin Hao, Yu Jiang, Can Zhang, and Pengfei Han
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human papilloma viruses (HPVs) ,deep learning ,oncogenicity ,E6 ,E7 ,Microbiology ,QR1-502 - Abstract
Human papillomaviruses (HPVs) account for more than 30% of cancer cases, with definite identification of the oncogenic role of viral E6 and E7 genes. However, the identification of high-risk HPV genotypes has largely relied on lagged biological exploration and clinical observation, with types unclassified and oncogenicity unknown for many HPVs. In the present study, we retrieved and cleaned HPV sequence records with high quality and analyzed their genomic compositional traits of dinucleotide (DNT) and DNT representation (DCR) to overview the distribution difference among various types of HPVs. Then, a deep learning model was built to predict the oncogenic potential of all HPVs based on E6 and E7 genes. Our results showed that the main three groups of Alpha, Beta, and Gamma HPVs were clearly separated between/among types in the DCR trait for either E6 or E7 coding sequence (CDS) and were clustered within the same group. Moreover, the DCR data of either E6 or E7 were learnable with a convolutional neural network (CNN) model. Either CNN classifier predicted accurately the oncogenicity label of high and low oncogenic HPVs. In summary, the compositional traits of HPV oncogenicity-related genes E6 and E7 were much different between the high and low oncogenic HPVs, and the compositional trait of the DCR-based deep learning classifier predicted the oncogenic phenotype accurately of HPVs. The trained predictor in this study will facilitate the identification of HPV oncogenicity, particularly for those HPVs without clear genotype or phenotype.
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- 2024
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99. Intratumoral high endothelial venules in solid tumors: a pooled study
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Bin Wang, Yin Han, Jie Liu, Xinyao Zhang, Yaotiao Deng, and Yu Jiang
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solid tumor ,high endothelial venules ,prognosis ,clinicopathological parameters ,immunotherapy ,Immunologic diseases. Allergy ,RC581-607 - Abstract
ObjectiveWe performed this pooled analysis for the first time to comprehensively explore the prognostic value of tumor-associated high endothelial venules (TA-HEVs) and determine their relationships with clinicopathological features in solid tumors.MethodsFour online databases, including PubMed, Web of Science, Embase, and Cochrane Library, were comprehensively searched to identify studies assessing the effect of TA-HEVs on prognosis or clinicopathological features. Hazard ratios (HRs) with 95% confidence intervals (CIs) were applied to evaluate survival outcomes, including overall survival (OS), disease-free survival (DFS), progression-free survival (PFS), and cancer-specific survival (CSS). The association between TA-HEV status and clinicopathological characteristics was assessed by odds ratios (ORs) combined with 95% CIs. Subgroup analysis was conducted to explore sources of heterogeneity. The sensitivity analysis was performed to evaluate the stability of our findings. Meanwhile, Funnel plots were employed to visually evaluate potential publication bias, and both Begg’s and Egger’s tests were adopted to quantitatively determine publication bias.ResultsA total of 13 retrospective cohort studies, involving 1,933 patients were finally included in this meta-analysis. Effect-size pooling analysis showed that the positivity of TA-HEVs was related to improved OS (pooled HR: 0.75, 95% CI: 0.62-0.93, P
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- 2024
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100. Semi Coke
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Qingbo, Meng, Yu, Jiang, and Kuangdi, Xu, editor
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- 2024
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