51. Effect of Pressure on Liver Stiffness During the Development of Liver Fibrosis in Rabbits
- Author
-
Qing Song, Rong Wu, Yu Kun Luo, Zi Yu Jiao, Wen Bo Tang, and Qinghua Xu
- Subjects
Liver Cirrhosis ,Male ,musculoskeletal diseases ,0301 basic medicine ,medicine.medical_specialty ,animal structures ,Acoustics and Ultrasonics ,Portal venous pressure ,medicine.medical_treatment ,Biophysics ,Gastroenterology ,Extracellular matrix ,03 medical and health sciences ,Hepatic Artery ,0302 clinical medicine ,Liver stiffness ,Internal medicine ,Laparotomy ,medicine ,Animals ,Arterial Pressure ,Radiology, Nuclear Medicine and imaging ,Ultrasonography ,Radiological and Ultrasound Technology ,Portal Vein ,business.industry ,Ultrasound ,equipment and supplies ,Portal Pressure ,Surgery ,Disease Models, Animal ,030104 developmental biology ,medicine.anatomical_structure ,Blood pressure ,Liver ,Female ,030211 gastroenterology & hepatology ,Rabbits ,business ,Ligation ,Artery - Abstract
This study was designed to investigate whether hepatic arterial pressure and portal pressure have an effect on liver stiffness during the development of liver fibrosis. Liver fibrosis was induced in 50 healthy New Zealand white rabbits. Laparotomy was performed to measure liver stiffness, and the portal vein and hepatic artery were successively ligated to repeat the measurements. A significant difference was observed among liver stiffness values measured at different time points (F = 22.82, p < 0.001). Differences between original liver stiffness and liver stiffness measured after portal ligation were positively correlated with portal pressure (r = 0.801, p < 0.001). In animals with grade 4 liver fibrosis, the increase in liver stiffness caused by pressure was greater than that caused by extracellular matrix accumulation (p = 0.002). In conclusion, hepatic arterial pressure and portal pressure have a significant effect on liver stiffness during the development of liver fibrosis.
- Published
- 2016