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A signal-sensor-based indoor pedestrian navigation system is developed. The proposed system: (i) utilizes a foot-mounted inertial navigation system (INS), in which the accumulated errors are mitigated via a zero velocity update (ZUPT) approach and (ii) exploits opportunistically cellular long-term evolution (LTE) signals in a deep neural network (DNN)-based synthetic aperture navigation (SAN) framework, in which the pedestrian’s motion is utilized to suppress multipath-induced errors. The proposed DNN-SAN-LTE-ZUPT-INS (DUALS) indoor pedestrian navigation system utilizes the complementary the desirable characteristics of both subsystems, coupled via two architectures: (a) loosely-coupled and (b) tightly-coupled. This paper designs and assesses both architectures experimentally in an indoor environment. The experimental study demonstrates a pedestrian traversing a trajectory of 600m in 14 minutes, including a stationary period of 85 seconds with a shoe-mounted inertial measurement unit (IMU) while receiving signals from 4 LTE base stations (also known as evolved node B (eNodeB)). The proposed tightly-coupled DUALS system exhibited a 3-D position root mean-squared error (RMSE) of 1.34 cm, outperforming the loosely-coupled DUALS, ZUPT-aided INS, and LTE-DNN-SAN which achieved a position RMSE of 1.38, 1.49, and 1.97 m, respectively.