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Background: The objective of the study to evaluate the effect of electroacupuncture during laparotomy in goats. Aim: To study the abdominal anaesthesia in goats by electroacupuncture using the physiological variables, vital parameters, haematological, biochemical, cortisol hormone, pain threshold and wound healing for laparotomy in goats. Methods: Fifteen healthy adult bucks were used to receive electroacupuncture in 10 newly selected acupoints. The data (M±SD) were assessed at intervals (0 min.) before induction (control group), (5 min.), (10 min.), (15 min.) and (20 min.) during induction, (30 min.), (45 min.) and (60 min.) throughout surgery and (24 hrs.) after surgery, cortisol levels in serum at (0), (24 hrs.), and (72 hrs.) throughout laparotomy. Results: The goats of the study showed improvement in the rates of eyelid closure, head, and neck relaxation, rumen motility, and tympany which were graded into mild (+), moderate (++), and severe (+++) degrees. The respiratory rates, body temperatures, and capillary fill times were not significantly different. The total mean of hematocrit was (19.9±2.68), the total mean of hemoglobin was (9.9±0.94), the total mean of RBCs was (7.9±0.8), the total mean of platelets was (244861.3±138444.8) and the total mean of SPO2 was (70.5±4.6). ALT and AST showed no significance. The significant mean cortisol level was (2.6±2.01) and the significant mean pain threshold level was (0.02±0.03). The results proved that electroacupuncture had a lot of significant parameters. The wound healing was improved by early epithelization and immature granulation tissue (at 7 days). Thick keratinized epithelization and collagen deposition in the dermal tissue with enhanced angiogenesis (at 14 days). Mild restoration of skin and the dermal tissue was well-organized (at 21 days). Besides, well-formed scar tissue covering a highly cellular organized dermal tissue (at 28 days). Conclusions: Electroacupuncture had been considered a powerful anaesthetic for abdominal surgery in goats. Moreover, wound healing proved excellent and better healing.

Background and Objectives: Determination of the impact of obstructive sleep apnea (OSA) on the cognitive function (CF), and serum tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and 1β levels and the effect of OSA management on these variables in children. Materials and Methods: A total of 224 patients were evaluated using the Pediatric Sleep Questionnaire, the NEPSY score for CF, and polysomnography (PSG) to grade OSA severity according to the apnea/hypopnea index (AHI). Adentonsillectomy (AT) was performed for patients with adenotonsillar hypertrophy grade > 2. Patients with overweight or obesity with mild or moderate OSAS underwent a 6-month protocol of lifestyle intervention (LSI). Blood samples were obtained for an enzyme-linked immunosorbent assay (ELISA) estimation of cytokine levels. All variables were re-evaluated at the end of the 6-month follow-up period. Results: A total of 181 patients had surgical interference and 43 patients underwent a LSI trial; 15 patients failed to respond and underwent surgery. At the end of the follow-up, 33 patients had residual OSAS with a significantly higher incidence among patients with severe OSAS, the mean score of the pediatric sleep questionnaire was significantly decreased in all patients, 181 patients showed an improved NESPY score, and cytokine levels were decreased. The baseline NESPY score, AHI index and sleep questionnaire score were negatively correlated. The percentage of change in the NESPY score and serum cytokine levels showed a positive correlation. Conclusions: OSAS is associated with cognitive dysfunction that significantly improves after adenotonsillectomy. LSI as a therapeutic line is satisfactory for children with mild OSAS and minimal cognitive dysfunction and is of value preoperatively to improve the surgical outcomes of AT.

The potential of plant-based natural compounds in the creation of new molluscicidal and antimicrobial medications has gained attention in recent years. The current study compared the metabolic profiles, antibacterial, and molluscicidal properties of the medicinal plants Calotropis procera (C. procera) and Atriplex halimus (A. halimus). In both plants, 118 metabolites were identified using gas chromatography-mass spectrometry. Palmitic acid, stigmasterol, and campesterol were the most prevalent constituents. C. procera extract showed stronger antibacterial activity than A. halimus against Escherichia coli and Proteus mirabilis. Both extracts exhibited molluscicidal activity against Biomphalaria alexandrina, with LC50 values of C. procera (135 mg/L) and A. halimus (223.8 mg/L). Survival rates of snails exposed to sub-lethal concentrations (LC25) of C. procera and A. halimus extracts were 5% and 20%, respectively. The hatchability of snail eggs exposed to both extracts has been dramatically reduced. Both extracts significantly decreased the levels of alkaline phosphatase, acid phosphatase, total protein, and albumin in snails, as well as causing DNA damage and resulting in numerous hermaphrodite and digestive gland damages and distortions. Molecular docking showed palmitic acid binding with acid, alkaline, and alanine aminotransferases in treated digestive gland snails. In conclusion, C. procera and A. halimus have antibacterial and molluscicidal properties.

Many complementary and alternative medicines have enjoyed increased popularity in recent decades. Efforts to validate their use have seen their putative therapeutic properties, which come under increasing scrutiny in vitro and in some cases in vivo. One of such products is tea and its tree oil (TTO); which is a secondary metabolite derived from tea plant (Melaleuca alternifolia). Both black and green tea has several polyphenolic compounds with possible antibacterial effects. It is employed largely due to its antimicrobial properties, and is incorporated as the active ingredient in many topical formulations used to treat cutaneous infections, in addition to being marketed as a remedy for various ailments. The essential oil of M. alternifolia exhibits broad-spectrum antimicrobial potential. The TTO may help to treat severe yeast infections. Results also suggested that TTO exerts a greater bactericidal potency against biofilm-grown methicillin-resistant Staphylococcus aureus (MRSA), and methicillin-sensitive Staph. aureus (MSSA) strains. Moreover, tea has inhibitory efficacy against the carcinogenic bacteria.

Summary: Bridgeless ac‐dc converters are the optimal choice for many applications, as they offer many advantages such as low distorted supply current, high power factor, and improved efficiency. This paper presents a new topology for a single‐phase bridgeless ac‐dc converter. The proposed hybrid topology is based on integrating the inverting and non‐inverting buck‐boost dc‐dc converters that are connected to the ac supply through an LC filter. To insure sinusoidal supply current, the proposed hybrid bridgeless ac‐dc converter is operated in discontinuous current mode. The proposed converter has many merits, such as a reduced number of components, enhanced efficiency, and soft start‐up capability. The operation modes and design of the proposed converter are presented. In addition, a design method is proposed for the input LC filter to minimize the voltage stress across switches. Moreover, a small signal model for the proposed converter is developed. The proposed converter topology is simulated to evaluate the dynamic behavior and verify the accuracy of the presented small signal model. Furthermore, an 850 W prototype is developed to validate the features of the proposed converter experimentally. Tight voltage regulation, sinusoidal supply current, and near‐to‐unity power factor operation are observed from the results, regardless of supply or load disturbances. [ABSTRACT FROM AUTHOR]

This paper presents the development of a numerical model for predicting and studying the effects of tool nose geometries and its interactions with cutting parameters during orthogonal cutting of AISI 1045 steel. The process performance characteristics studied were cutting temperature, effective stress, cutting forces and tool wear. The cutting simulations were done using the commercial DEFORM-2D R V 11.3 software, based on the finite element method (FEM). The cutting tool used had a round nose with various nose radii (0.01–0.9 mm), while the machining parameters tested were the feed rate (0.1–0.3 mm/rev), the cutting speed (100–500 m/min) and the rake angle (–5° to +10°). The interactions between the tool nose radius and the cutting parameters (speed, feed) were found to affect mostly the cutting stress and, slightly, the tool wear rate. These interactions did not much influence the cutting temperature, that was found to be high when the tool nose radius and/or the cutting speed were high. The maximum temperature was found to occur at the middle of the tool-chip contact length and at the interaction of nose radius and flank face of the tool. Except for some fluctuations, there was no significant difference in tool wear rate between small and large nose radius scales.

Background and Objectives: Obstructive sleep apnea (OSA) is a sleep-related respiratory disorder that affects between 5% and 20% of the population. In obstructive sleep apnea, lingual tonsillar hypertrophy (LTH) has been suggested as a contributing factor to airway blockage. Objectives: The aim of this work is to demonstrate the polysomnographic indices and their values in OSA patients with LTH before and after the surgical intervention. Materials and Methods: The study was conducted on eighteen patients endoscopically diagnosed as having LTH, with the main complaints being snoring, sleep apnea, and/or sleep disturbance. Clinical examination, grading of LTH, body mass index (BMI), endoscopic assessment using Muller’s maneuver, and sleep endoscopy were recorded for all patients. The Epworth Sleepiness Scale (ESS) and overnight sleep polysomnography (PSG) were conducted before and after the surgical removal of LTH. All data were submitted for statistical analysis. Results: The mean ± SD of the AHI decreased from 33.89 ± 26.8 to 20.9 ± 19.14 postoperatively, and this decrease was of insignificant statistical value. The average SpO2 (%) mean ± SD was 91.14 ± 5.96, while the mean ± SD of the desaturation index was 34.64 ± 34.2. Following surgery, these indices changed to 96.5 ± 1.47 and 9.36 ± 7.58, respectively. The mean ± SD of the ESS was changed after the surgery, from 17.27 ± 6.48 to 7.16 ± 3.56. The mean ± SD of sleep efficacy was 71.2 ± 16.8 and the snoring index mean ± SD was 277.6 ± 192.37, and both improved postoperatively, to become 88.17 ± 9.1 and 62.167 ± 40.01, respectively. Conclusions: The AHI after lingual tonsillectomy showed no statistically significant change. The changes in the average SpO2 (%), desaturation index, sleep efficiency, snoring index, and Epworth Sleepiness Scale following the surgery were statistically significant.