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With the rapid development of society, people’s awareness of environmental protection continues to strengthen, countries also pay more and more attention to environmental protection, whether from the national policy or from the green development of enterprises in the future, the improvement of power plant operation efficiency is imperative. Among them, improving the operation efficiency of thermal power plants is the top priority, and it is also an important link of national economic transformation. The design of electrical part is an important part of improving the operation efficiency of thermal power plants. 2x300MW thermal power plant is designed, including the power plant electrical main wiring design, plant power design, the main circuit of the power plant short-circuit calculation, and it choose the electrical stability and thermal stability of the better electrical equipment. The short circuit calculation of the main circuit of the power plant is carried out and preliminary planning of the secondary circuit scheme is made. A power plant with higher operating efficiency is designed. While improving the operation and economic efficiency of the power plant, it also ensures the reliability, stability and economy of the power plant.

Background As socioeconomic status and population health develop, death patterns and disease spectrum have changed. The impact of diseases on life expectancy have changed as well. Objective To analyze the change in life expectancy and disease spectrum in residents of Jing'an District in Shanghai from 2016 to 2021. Methods Population data and mortality data of permanent residents in Jing'an District of Shanghai from 2016 to 2021 were collected from the Public Security Bureau of Jing'an District, and the Jing'an District Mortality Surveillance System. The ICD-10 was used to categorize the underlying causes of death. The Abridged Life Tables and Arriaga's decomposition method were used to analyze the impacts of age groups and causes of death on life expectancy. Results The life expectancy of these residents from 2016 to 2021 ranged from 83.68 to 84.40 years, which increased by 0.72 years in 2021 compared with that of 2016. The life expectancy of male residents was 81.47 to 82.15 years, demonstrating an increase of 0.68 years during the period. The life expectancy was 85.95 to 86.74 years for female residents, showing an increase of 0.79 years during the period. The decrease of mortality rate in 65 to 84 age group contributed 83.29% to the increase of the life expectancy (0.60 years) , while the decrease of mortality rate in 15 to 44 age group contributed -17.18% to the increase of the life expectancy (-0.12 years) . The largest contribution to the increase of life expectancy was the mortality reduction in cancer, followed by that in respiratory disease, which contributed 56.20% and 53.55%, respectively. The largest contribution to the decrease of life expectancy was increased mortality due to injuries and poisoning, followed by that due to endocrine, nutritional and metabolic diseases, which contributed -35.69% and -17.25%, respectively. Conclusion The life expectancy of residents in Jing'an District from 2016 to 2021 was 83.68 to 84.40 years, seeing an increase of 0.72 years. The increase of life expectancy was mainly attributed to the decrease of mortality in 65 to 84 age group and the decrease of mortality due to cancer. However, the increase of mortality due to injuries and poisoning had negative contribution.

In order to study the corrosion behavior of 316L and 2205 stainless steels and explore their application prospects in underwater production systems, the corrosion rate, electrochemical behavior and pitting corrosion resistance of 316L and 2205 stainless steels were analyzed and compared by using long period immersion test, cyclic polarization curve, potentiostatic polarization and electrochemical impedance spectroscopy (EIS) with the help of scanning electron microscope (SEM) and energy dispersive spectrometer (EDS). Results showed that the corrosion resistance of 2205 duplex stainless steel was better than that of 316L austenitic stainless steel in the simulated seawater environment with high CO2 content. Compared with 316L stainless steel, 2205 stainless steel had larger passive region, lower passive current density and larger passive film resistance. The high corrosion resistance of 2205 stainless steel was attributed to its higher pitting resistance equivalent (PREN) value and fewer inclusions, which enabled the passive film on the surface of 2205 stainless steel more stable and less prone to localized damage.

ObjectiveTo analyze the epidemiological characteristics of senile dementia death in Jing’an District from 2016 to 2020， as well as the trends of mortality， standardized mortality， years of life lost （YLL） due to early death， years lived with disability （YLD）， and disability-adjusted life year （DALY）， and to provide scientific basis for the prevention and control of senile dementia.MethodsThe distribution of senile dementia in terms of gender， age， marital status and education level was investigated in the senile dementia death cases from 2016 to 2020 in Jing’an District. The YLL， YLD， DALY and their rates of the residents of Jing’an District from 2016 to 2020 were calculated by using Global Burden of Disease （GBD 2019） research method and results in combination with the corresponding population data.ResultsCompared to those without dementia， deaths with dementia were more likely to be female， more likely to be over 80 years old， less likely to be married， and more likely to have education level under middle school. Among the deaths with dementia， only 27.70% of the primary cause of death was dementia， and the other main causes were cerebrovascular disease， coronary heart disease and diabetes mellitus， which accounted for 25.54%， 17.81% and 7.28%， respectively. There was a significant gender difference in the burden of disease on senile dementia in Jing’an District. Mortality， standardized mortality， YLL， YLD and DALY rates of females were higher than those of males. The burden of disease on senile dementia increased with age. The change trend of mortality and YLL rate from 2016 to 2020 was not statistically significant， while the YLD rate and DALY rate showed an upward trend， which was statistically significant.ConclusionAs the life span of residents in Jing’an District increases and the population aging deepens， the burden of disease on senile dementia is still heavy. This requires extensive attention of the whole society， and active exploration of prevention and control strategies and measures for senile dementia， so as to improve the life quality of patients and reduce the burden of disease.

A method for measuring (n,α) reaction cross sections of the gas sample induced by fast neutrons using a gridded ionization chamber (GIC) was established. There are several advantages using the GIC to measure gas samples. With this method, the (n,α) reaction cross sections of inert gases which are hard to exist as a solid can be measured. And the (n,α) reaction cross section for α particle emitting in all directions can be directly measured by using the gas sample. Furthermore, compared with using solid samples, using gas samples have far more nuclei in the measurement samples. Therefore, it is feasible to use neutron source with a better energy resolution to measure the resonance cross sections with gas sample. However, there are many problems to be solved when measuring (n,α) reaction cross section of gas sample by using the GIC. On the one hand, the nuclear reaction event will be affected by the wall effect, when the nuclear reaction is generated near the electrodes of the GIC or at the edge of the electric field. The wall effect will cause the measured event to locate outside the event area which cannot be counted. Not only is the number of nuclei of the gas samples involved in the (n,α) reaction difficult to determine, but the number of events, which are affected by the background or located below the threshold, is also difficult to count. On the other hand, the neutron fluence involved in the measurement of (n,α) reaction cross section of gas sample is difficult to measure. Aiming at solving the problems of the determination of the sample nuclei number, the measurement of neutron fluence, and the selection of events, which are all difficult for the gas sample, this method included three steps: First, simulation calculation was performed to select a suitable effective volume of the gas samples, so that the event is free of background and easy to be counted. Second, the neutron collimator and the timing information of cathode and anode signals were used to select and count the events generated in the effective volume of the gas sample. Third, combining the fission fragment measurement of the 238U(n,f) reaction and the simulation based on SuperMC, the neutron fluence through the effective volume was obtained. Measurements of relative cross sections of the 14N(n,α0) reaction using gas sample were performed at En=471, 487, 500, 512, 529, and 545 MeV. The results are in good agreement with those of ENDF/BⅧ.0 which verified the present measurement method.

As a kind of proteolytic enzyme extracted from earthworms, lumbrokinase has been used as an antithrombotic drug clinically. Nevertheless, its potential in anti-cancer, especially in anti-non-small cell lung cancer (NSCLC), as a single form of treatment or in combination with other therapies, is still poorly understood. In this study, we explored the anti-tumor role and the responsive molecular mechanisms of lumbrokinase in suppressing tumor angiogenesis and chemoresistance development in NSCLC and its clinical potential in combination with bevacizumab and chemotherapeutics. Lumbrokinase was found to inhibit cell proliferation in a concentration-dependent manner and caused metastasis suppression and apoptosis induction to varying degrees in NSCLC cells. Lumbrokinase enhanced the anti-angiogenesis efficiency of bevacizumab by down-regulating BPTF expression, decreasing its anchoring at the VEGF promoter region and subsequent VEGF expression and secretion. Furthermore, lumbrokinase treatment reduced IC50 values of chemotherapeutics and improved their cytotoxicity in parental and chemo-resistant NSCLC cells via inactivating the NF-κB pathway, inhibiting the expression of COX-2 and subsequent secretion of PGE2. LPS-induced NF-κB activation reversed its inhibition on NSCLC cell proliferation and its synergy with chemotherapeutic cytotoxicity, while COX-2 inhibitor celecoxib treatment boosted such effects. Lumbrokinase combined with bevacizumab, paclitaxel, or vincristine inhibited the xenograft growth of NSCLC cells in mice more significantly than a single treatment. In conclusion, lumbrokinase inhibited NSCLC survival and sensitized NSCLC cells to bevacizumab or chemotherapeutics treatment by targeted down-regulation of BPTF/VEGF signaling and inactivation of NF-κB/COX-2 signaling, respectively. The combinational applications of lumbrokinase with bevacizumab or chemotherapeutics are expected to be developed as promising candidate therapeutic strategies to improve the efficacy of the original monotherapy in anti-NSCLC. [ABSTRACT FROM AUTHOR]

Oncolytic virotherapy is expected to provide a new treatment strategy for cancer. Aphrocallistes vastus lectin (AVL) is a Ca2+-dependent lectin receptor containing the conserved domain of C-type lectin and the hydrophobic N-terminal region, which can bind to the bird's nest glycoprotein and D-galactose. Our previous studies suggested that the oncolytic vaccinia virus (oncoVV) armed with the AVL gene exerted remarkable replication and antitumor effects in vitro and in vivo. In this study, we found that oncoVV-AVL may reprogram the metabolism of hepatocellular carcinoma cells to promote ROS, and elevated ROS subsequently promoted viral replication and induced apoptosis. This study will provide a new theoretical basis for the application of oncoVV-AVL in liver cancer. [ABSTRACT FROM AUTHOR]

The preparation of a single crystal superalloy surface overlay welding coating to improve its high-temperature mechanical properties is of great significance for prolonging the service life of blades. This work selected two types of welding wire alloys, CoCrMo and CoCrW, to prepare coatings on the surface of a single crystal superalloy. A comparative study was conducted on their mechanical properties, such as tension, compression, fatigue, durability, and wear at a high temperature of 900 ℃, aiming to reveal the high-temperature mechanical properties of the two types of welding coatings. Results showed that the average high-temperature tensile strength of the CoCrMo welded specimen was smaller than that of the CoCrW welded specimen; the average high-temperature duration of CoCrMo welded specimens at 150 MPa was lower than the average duration of CoCrW welded specimens; the high-temperature fatigue life of CoCrMo welded specimens at 220 MPa was 7.186 × 105; and the average high-temperature wear rate of CoCrMo sample was 3.64 × 10−6 mm3·N−1·m−1. The CoCrW alloy was more wear resistant than CoCrMo. The hardness of CoCrMo welded joints gradually increased from the substrate to the heat-affected zone and then to the fusion zone, and was much higher in the fusion zone than in the CoCrW alloy. [ABSTRACT FROM AUTHOR]