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51. A subset of Kupffer cells regulates metabolism through the expression of CD36

Author

Blériot, Camille, primary, Barreby, Emelie, additional, Dunsmore, Garett, additional, Ballaire, Raphaelle, additional, Chakarov, Svetoslav, additional, Ficht, Xenia, additional, De Simone, Giorgia, additional, Andreata, Francesco, additional, Fumagalli, Valeria, additional, Guo, Wei, additional, Wan, Guochen, additional, Gessain, Gregoire, additional, Khalilnezhad, Ahad, additional, Zhang, Xiao Meng, additional, Ang, Nicholas, additional, Chen, Ping, additional, Morgantini, Cecilia, additional, Azzimato, Valerio, additional, Kong, Wan Ting, additional, Liu, Zhaoyuan, additional, Pai, Rhea, additional, Lum, Josephine, additional, Shihui, Foo, additional, Low, Ivy, additional, Xu, Connie, additional, Malleret, Benoit, additional, Kairi, Muhammad Faris Mohd, additional, Balachander, Akhila, additional, Cexus, Olivier, additional, Larbi, Anis, additional, Lee, Bernett, additional, Newell, Evan W., additional, Ng, Lai Guan, additional, Phoo, Wint Wint, additional, Sobota, Radoslaw M., additional, Sharma, Ankur, additional, Howland, Shanshan W., additional, Chen, Jinmiao, additional, Bajenoff, Marc, additional, Yvan-Charvet, Laurent, additional, Venteclef, Nicolas, additional, Iannacone, Matteo, additional, Aouadi, Myriam, additional, and Ginhoux, Florent, additional

Published
2021
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52. Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

Author

Mulder, Kevin, primary, Patel, Amit Ashok, additional, Kong, Wan Ting, additional, Piot, Cécile, additional, Halitzki, Evelyn, additional, Dunsmore, Garett, additional, Khalilnezhad, Shabnam, additional, Irac, Sergio Erdal, additional, Dubuisson, Agathe, additional, Chevrier, Marion, additional, Zhang, Xiao Meng, additional, Tam, John Kit Chung, additional, Lim, Tony Kiat Hon, additional, Wong, Regina Men Men, additional, Pai, Rhea, additional, Khalil, Ahmed Ibrahim Samir, additional, Chow, Pierce Kah Hoe, additional, Wu, Suny Z., additional, Al-Eryani, Ghamdan, additional, Roden, Daniel, additional, Swarbrick, Alexander, additional, Chan, Jerry Kok Yen, additional, Albani, Salvatore, additional, Derosa, Lisa, additional, Zitvogel, Laurence, additional, Sharma, Ankur, additional, Chen, Jinmiao, additional, Silvin, Aymeric, additional, Bertoletti, Antonio, additional, Blériot, Camille, additional, Dutertre, Charles-Antoine, additional, and Ginhoux, Florent, additional

Published
2021
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55. Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis

Author

Nakamizo, Satoshi, primary, Dutertre, Charles-Antoine, additional, Khalilnezhad, Ahad, additional, Zhang, Xiao Meng, additional, Lim, Shawn, additional, Lum, Josephine, additional, Koh, Geraldine, additional, Foong, Charlene, additional, Yong, Pearly Jean Ai, additional, Tan, Kahbing Jasmine, additional, Sato, Reiko, additional, Tomari, Kaori, additional, Yvan-Charvet, Laurent, additional, He, Helen, additional, Guttman-Yassky, Emma, additional, Malleret, Benoit, additional, Shibuya, Rintaro, additional, Iwata, Masashi, additional, Janela, Baptiste, additional, Goto, Tsuyoshi, additional, Lucinda, Tan Siyun, additional, Tang, Mark B.Y., additional, Theng, Colin, additional, Julia, Valerie, additional, Hacini-Rachinel, Feriel, additional, Kabashima, Kenji, additional, and Ginhoux, Florent, additional

Published
2021
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57. Microbial exposure during early human development primes fetal immune cells

Author

Mishra, Archita, primary, Lai, Ghee Chuan, additional, Yao, Leong Jing, additional, Aung, Thet Tun, additional, Shental, Noam, additional, Rotter-Maskowitz, Aviva, additional, Shepherdson, Edwin, additional, Singh, Gurmit Singh Naranjan, additional, Pai, Rhea, additional, Shanti, Adhika, additional, Wong, Regina Men Men, additional, Lee, Andrea, additional, Khyriem, Costerwell, additional, Dutertre, Charles Antoine, additional, Chakarov, Svetoslav, additional, Srinivasan, K.G., additional, Shadan, Nurhidaya Binte, additional, Zhang, Xiao-Meng, additional, Khalilnezhad, Shabnam, additional, Cottier, Fabien, additional, Tan, Alrina Shin Min, additional, Low, Gillian, additional, Chen, Phyllis, additional, Fan, Yiping, additional, Hor, Pei Xiang, additional, Lee, Avery Khoo May, additional, Choolani, Mahesh, additional, Vermijlen, David, additional, Sharma, Ankur, additional, Fuks, Garold, additional, Straussman, Ravid, additional, Pavelka, Norman, additional, Malleret, Benoit, additional, McGovern, Naomi, additional, Albani, Salvatore, additional, Chan, Jerry Kok Yen, additional, and Ginhoux, Florent, additional

Published
2021
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58. Additional file 4 of A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation

Author

Wu, Chao, Huang, Zhi-Hong, Meng, Zi-Qi, Fan, Xiao-Tian, Lu, Shan, Tan, Ying-Ying, You, Lei-Ming, Huang, Jia-Qi, Stalin, Antony, Ye, Pei-Zhi, Wu, Zhi-Shan, Zhang, Jing-Yuan, Liu, Xin-Kui, Zhou, Wei, Zhang, Xiao-Meng, and Wu, Jia-Rui

Abstract

Additional file 4: Table S2. Genes associated with PC.

Published
2021
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59. Additional file 5 of A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation

Author

Wu, Chao, Huang, Zhi-Hong, Meng, Zi-Qi, Fan, Xiao-Tian, Lu, Shan, Tan, Ying-Ying, You, Lei-Ming, Huang, Jia-Qi, Stalin, Antony, Ye, Pei-Zhi, Wu, Zhi-Shan, Zhang, Jing-Yuan, Liu, Xin-Kui, Zhou, Wei, Zhang, Xiao-Meng, and Wu, Jia-Rui

Abstract

Additional file 5: Table S3. Information of potential key targets in CKI-PC PPI network.

Published
2021
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60. Additional file 3 of A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation

Author

Wu, Chao, Huang, Zhi-Hong, Meng, Zi-Qi, Fan, Xiao-Tian, Lu, Shan, Tan, Ying-Ying, You, Lei-Ming, Huang, Jia-Qi, Stalin, Antony, Ye, Pei-Zhi, Wu, Zhi-Shan, Zhang, Jing-Yuan, Liu, Xin-Kui, Zhou, Wei, Zhang, Xiao-Meng, and Wu, Jia-Rui

Abstract

Additional file 3: Table S1. Information about the 16 compounds of CKI.

Published
2021
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61. Microbial exposure during early human development primes fetal immune cells

Author

Mishra, Archita, Lai, Ghee Chuan, Yao, Leong Jing, Aung, Thet Tun, Shental, Noam, Rotter-Maskowitz, Aviva, Shepherdson, Edwin, Singh, Gurmit Singh Naranjan, Pai, Rhea, Shanti, Adhika, Wong, Regina Men Men, Lee, Andrea, Khyriem, Costerwell, Dutertre, Charles Antoine, Chakarov, Svetoslav, Srinivasan, K.G., Shadan, Nurhidaya Binte, Zhang, Xiao-Meng, Khalilnezhad, Shabnam, Cottier, Fabien, Tan, Alrina Shin Min, Low, Gillian, Chen, Phyllis, Fan, Yiping, Hor, Pei Xiang, Lee, Avery Khoo May, Choolani, Mahesh, Vermijlen, David, Sharma, Ankur, Fuks, Garold, Straussman, Ravid, Pavelka, Norman, Malleret, Benoit, McGovern, Naomi, Albani, Salvatore, Chan, Jerry Kok Yen, Ginhoux, Florent, Mishra, Archita, Lai, Ghee Chuan, Yao, Leong Jing, Aung, Thet Tun, Shental, Noam, Rotter-Maskowitz, Aviva, Shepherdson, Edwin, Singh, Gurmit Singh Naranjan, Pai, Rhea, Shanti, Adhika, Wong, Regina Men Men, Lee, Andrea, Khyriem, Costerwell, Dutertre, Charles Antoine, Chakarov, Svetoslav, Srinivasan, K.G., Shadan, Nurhidaya Binte, Zhang, Xiao-Meng, Khalilnezhad, Shabnam, Cottier, Fabien, Tan, Alrina Shin Min, Low, Gillian, Chen, Phyllis, Fan, Yiping, Hor, Pei Xiang, Lee, Avery Khoo May, Choolani, Mahesh, Vermijlen, David, Sharma, Ankur, Fuks, Garold, Straussman, Ravid, Pavelka, Norman, Malleret, Benoit, McGovern, Naomi, Albani, Salvatore, Chan, Jerry Kok Yen, and Ginhoux, Florent

Abstract

The human fetal immune system begins to develop early during gestation; however, factors responsible for fetal immune-priming remain elusive. We explored potential exposure to microbial agents in utero and their contribution toward activation of memory T cells in fetal tissues. We profiled microbes across fetal organs using 16S rRNA gene sequencing and detected low but consistent microbial signal in fetal gut, skin, placenta, and lungs in the 2nd trimester of gestation. We identified several live bacterial strains including Staphylococcus and Lactobacillus in fetal tissues, which induced in vitro activation of memory T cells in fetal mesenteric lymph node, supporting the role of microbial exposure in fetal immune-priming. Finally, using SEM and RNA-ISH, we visualized discrete localization of bacteria-like structures and eubacterial-RNA within 14th weeks fetal gut lumen. These findings indicate selective presence of live microbes in fetal organs during the 2nd trimester of gestation and have broader implications toward the establishment of immune competency and priming before birth., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

64. Additional file 1 of Comparative efficacy, safety and cost of oral Chinese patent medicines for rheumatoid arthritis: a Bayesian network meta-analysis

Author

Zhang, Dan, Lyu, Jin-Tao, Zhang, Bing, Zhang, Xiao-Meng, Jiang, Hao, and Lin, Zhi-Jian

Abstract

Additional file 1 Supplementary file 1. PRISMA check list. Supplementary file 2. Search strategy. Supplementary file 3. PRISMA flow chart. Supplementary Table S1. The product information (raw materials, labeled efficacy, indications) of CPMs. Supplementary Table S2. The baseline characteristics of the included RCTs and subjects. Supplementary Table S3. Results of the network meta-analysis for joint tenderness (upper-right quadrant) and the joint swelling (lower-left quadrant). Supplementary Table S4. Results of the network meta-analysis for morning stiffness (upper-right quadrant) and ESR (lower-left quadrant). Supplementary Table S5. Risk-of-bias judgements for the included RCTs (RoB 2)

Published
2020
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65. Ta-Coated Titanium Surface With Superior Bacteriostasis And Osseointegration

Author

Zhang, Xiao-Meng, Li, Yuan, Gu, Ying-Xin, Zhang, Chu-Nan, Lai, Hong-Chang, and Shi, Jun-Yu

Subjects
ATP synthesis, Dental Implants, Male, Titanium, Fusobacterium nucleatum, tantalum-coating, Surface Properties, Colony Count, Microbial, osseointegration, Gene Expression Regulation, Bacterial, Tantalum, Anti-Bacterial Agents, Adenosine Triphosphate, Dogs, antibacterial activity, Coated Materials, Biocompatible, International Journal of Nanomedicine, ROS generation, Animals, Lipid Peroxidation, Reactive Oxygen Species, Porphyromonas gingivalis, Original Research
Abstract

Xiao-Meng Zhang,* Yuan Li,* Ying-Xin Gu, Chu-Nan Zhang, Hong-Chang Lai, Jun-Yu Shi Department of Implant Dentistry, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong-Chang Lai; Jun-Yu ShiDepartment of Implant Dentistry, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 500 Quxi Road, Shanghai 200011, People’s Republic of ChinaTel +86 21 23271699 (ext. 5298)Fax +86 21 53073068Email lhc9@hotmail.com; sakyamuni_jin@163.comBackground: Although tantalum (Ta)-based coatings have been proven to have good antibacterial activity, the underlying mechanism and in vivo biological performance remain unclear, which are essential for the clinical application of Ta-coated biomaterials as dental implants.Purpose: The main objective of this study is to investigate the antibacterial activity of Ta-modified titanium (Ti) implants against peri-implantitis-related microbes and the potential molecular mechanisms.Methods: Fusobacterium nucleatum and Porphyromonas gingivalis were selected to evaluate the antibacterial activity and potential antibacterial mechanism of Ta modification. The in vivo biocompatibility of Ta-modified implants was also evaluated.Results: The results showed that Ta-modified surface performed excellent antimicrobial activity against Fusobacterium nucleatum and Porphyromonas gingivalis. Micro galvanic might be formed between the incorporated Ta and the Ti base, which could consume the protons and result in decreased ATP synthesis and increased ROS generation. The gene expression of bacterial virulence factors associated with cellular attachment, invasion and viability as the target of ROS was downregulated. Importantly, in vivo biological studies showed that Ta modification significantly promoted the osseointegration of implants by stimulating the expression of bone-forming proteins.Conclusion: This study may provide some insights into clinical applications of Ta-coated Ti implants, especially in possibly infected situations.Keywords: tantalum-coating, antibacterial activity, ATP synthesis, ROS generation, osseointegration

Published
2019

67. Serum Anti-AP3D1 Antibodies Are Broad-Spectrum Biomarkers for Atherosclerosis, Acute Ischemic Stroke, Cardiovascular Disease, Diabetes Mellitus, Chronic Kidney Disease, and Digestive Organ Cancer

Author

Li, Shu-Yang, primary, Yoshida, Yoichi, additional, Kobayashi, Eiichi, additional, Kubota, Masaaki, additional, Matsutani, Tomoo, additional, Mine, Seiichiro, additional, Machida, Toshio, additional, Wada, Takeshi, additional, Aotsuka, Akiyo, additional, Maezawa, Yoshiro, additional, Takemoto, Minoru, additional, Yokote, Koutaro, additional, Kobayashi, Yoshio, additional, Kitamura, Kenichiro, additional, Takizawa, Hirotaka, additional, Kashiwado, Koichi, additional, Sata, Mizuki, additional, Yamagishi, Kazumasa, additional, Iso, Hiroyasu, additional, Sawada, Norie, additional, Tsugane, Shoichiro, additional, Kobayashi, Sohei, additional, Matsushita, Kazuyuki, additional, Nomura, Fumio, additional, Matsubara, Hisahiro, additional, Sumazaki, Makoto, additional, Ito, Masaaki, additional, Yajima, Satoshi, additional, Shimada, Hideaki, additional, Iwase, Katsuro, additional, Ashino, Hiromi, additional, Zhang, Xiao-Meng, additional, Wang, Hao, additional, Goto, Kenichiro, additional, Tomiyoshi, Go, additional, Shinmen, Natsuko, additional, Nakamura, Rika, additional, Kuroda, Hideyuki, additional, Iwadate, Yasuo, additional, and Hiwasa, Takaki, additional

Published
2020
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71. Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells

Author

Baharom, Faezzah, primary, Ramirez-Valdez, Ramiro A., additional, Tobin, Kennedy K. S., additional, Yamane, Hidehiro, additional, Dutertre, Charles-Antoine, additional, Khalilnezhad, Ahad, additional, Reynoso, Glennys V., additional, Coble, Vincent L., additional, Lynn, Geoffrey M., additional, Mulè, Matthew P., additional, Martins, Andrew J., additional, Finnigan, John P., additional, Zhang, Xiao Meng, additional, Hamerman, Jessica A., additional, Bhardwaj, Nina, additional, Tsang, John S., additional, Hickman, Heather D., additional, Ginhoux, Florent, additional, Ishizuka, Andrew S., additional, and Seder, Robert A., additional

Published
2020
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73. Identification of soft rot resistance loci in Brassica rapawith SNP markers

Author

LIU, Meng-yang, WU, Fang, GE, Yun-jia, LU, Yin, ZHANG, Xiao-meng, WANG, Yan-hua, WANG, Yang, YAN, Jing-hui, SHEN, Shu-xing, ZHAO, Jian-jun, and MA, Wei

Abstract

Soft rot caused by Pectobacterium carotovorum(Pc) is a devastating disease of Brassica rapa, causing substantial reductions in crop yield and quality. Identifying genes related to soft rot resistance is the key to solving this problem. To characterize soft rot resistance, we screened a soft rot-susceptible Chinese cabbage (A03), a resistant pakchoi (‘Huaguan’), and a resistant mutant (sr). An F2population was generated by crossing susceptible Chinese cabbage A03 and resistant pakchoi ‘Huaguan’ to identify quantitative trait loci (QTLs) that confer soft rot resistance. A high-density genetic map was constructed and the three QTLs identified contain 166 genes. Based on available transcriptome data, we analyzed the expression of the 166 genes during an important defense regulatory period in Pcinfection in both A03 and the resistant mutant sr. Among the 166 genes, six candidate genes were related to the soft rot defense response in B. rapa. TIFY10B(JAZ2, BraA07g038660.3C) was located in the major soft rot resistance QTL, DRQTL-3 on A07, and we speculate that this gene may play an important role in the defense mechanism against soft rot in B. rapa. This study lays the foundation for further investigations on the mechanism of soft rot resistance in B. rapacrops.

Published
2022
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76. Serum anti‐LRPAP1 is a common biomarker for digestive organ cancers and atherosclerotic diseases

Author

Sumazaki, Makoto, primary, Shimada, Hideaki, additional, Ito, Masaaki, additional, Shiratori, Fumiaki, additional, Kobayashi, Eiichi, additional, Yoshida, Yoichi, additional, Adachi, Akihiko, additional, Matsutani, Tomoo, additional, Iwadate, Yasuo, additional, Mine, Seiichiro, additional, Machida, Toshio, additional, Kamitsukasa, Ikuo, additional, Mori, Masahiro, additional, Sugimoto, Kazuo, additional, Uzawa, Akiyuki, additional, Kuwabara, Satoshi, additional, Kobayashi, Yoshio, additional, Ohno, Mikiko, additional, Nishi, Eiichiro, additional, Maezawa, Yoshiro, additional, Takemoto, Minoru, additional, Yokote, Koutaro, additional, Takizawa, Hirotaka, additional, Kashiwado, Koichi, additional, Shin, Hideo, additional, Kishimoto, Takashi, additional, Matsushita, Kazuyuki, additional, Kobayashi, Sohei, additional, Nakamura, Rika, additional, Shinmen, Natsuko, additional, Kuroda, Hideyuki, additional, Zhang, Xiao‐Meng, additional, Wang, Hao, additional, Goto, Ken‐ichiro, additional, and Hiwasa, Takaki, additional

Published
2020
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78. Association of serum levels of antibodies against ALDOA and FH4 with transient ischemic attack and cerebral infarction

Author

Wang, Hao, primary, Lu, Hao, additional, Zhang, Xiao-Meng, additional, Goto, Ken-ichiro, additional, Kobayashi, Eiichi, additional, Yoshida, Yoichi, additional, Adachi, Akihiko, additional, Matsutani, Tomoo, additional, Iwadate, Yasuo, additional, Min, Seiichiro, additional, Machida, Toshio, additional, Sata, Mizuki, additional, Yamagishi, Kazumasa, additional, Iso, Hiroyasu, additional, Sawada, Norie, additional, Tsugane, Shoichiro, additional, Kamitsukasa, Ikuo, additional, Wada, Takeshi, additional, Aotsuka, Akiyo, additional, Sugimoto, Kazuo, additional, Takizawa, Hirotaka, additional, Kashiwado, Koichi, additional, Shin, Hideo, additional, Tomiyoshi, Go, additional, Nakamura, Rika, additional, Shinmen, Natsuko, additional, Kuroda, Hideyuki, additional, Xu, Anding, additional, and Hiwasa, Takaki, additional

Published
2020
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80. Association between serum anti‑ASXL2 antibody levels and acute ischemic stroke, acute myocardial infarction, diabetes mellitus, chronic kidney disease and digestive organ cancer, and their possible association with atherosclerosis and hypertension

Author

Li, Shu‑Yang, primary, Yoshida, Yoichi, additional, Kobayashi, Eiichi, additional, Adachi, Akihiko, additional, Hirono, Seiichiro, additional, Matsutani, Tomoo, additional, Mine, Seiichiro, additional, Machida, Toshio, additional, Ohno, Mikiko, additional, Nishi, Eiichiro, additional, Maezawa, Yoshiro, additional, Takemoto, Minoru, additional, Yokote, Koutaro, additional, Kitamura, Kenichiro, additional, Sumazaki, Makoto, additional, Ito, Masaaki, additional, Shimada, Hideaki, additional, Takizawa, Hirotaka, additional, Kashiwado, Koichi, additional, Tomiyoshi, Go, additional, Shinmen, Natsuko, additional, Nakamura, Rika, additional, Kuroda, Hideyuki, additional, Zhang, Xiao‑Meng, additional, Wang, Hao, additional, Goto, Kenichiro, additional, Iwadate, Yasuo, additional, and Hiwasa, Takaki, additional

Published
2020
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83. Association of serum levels of antibodies against ALDOA and FH4 with transient ischemic attack and cerebral infarction

Author

Wang, Hao Hao, primary, Lu, Hao Hao, additional, Zhang, Xiao-Meng Xiao-Meng, additional, Goto, Ken-ichiro Ken-ichiro, additional, Kobayashi, Eiichi Eiichi, additional, Yoshida, Yoichi Yoichi, additional, Adachi, Akihiko Akihiko, additional, Matsutani, Tomoo Tomoo, additional, Iwadate, Yasuo Yasuo, additional, Min, Seiichiro Seiichiro, additional, Machida, Toshio Toshio, additional, Sata, Mizuki Mizuki, additional, Yamagishi, Kazumasa Kazumasa, additional, Iso, Hiroyasu Hiroyasu, additional, Sawada, Norie Norie, additional, Tsugane, Shoichiro Shoichiro, additional, Kamitsukasa, Ikuo Ikuo, additional, Wada, Takeshi Takeshi, additional, Aotsuka, Akiyo Akiyo, additional, Sugimoto, Kazuo Kazuo, additional, Takizawa, Hirotaka Hirotaka, additional, Kashiwado, Koichi Koichi, additional, Shin, Hideo Hideo, additional, Tomiyoshi, Go Go, additional, Nakamura, Rika Rika, additional, Shinmen, Natsuko Natsuko, additional, Kuroda, Hideyuki Hideyuki, additional, Xu, Anding Anding, additional, and Hiwasa, Takaki, additional

Published
2020
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85. Circulating Anti-Sorting Nexins 16 Antibodies as an Emerging Biomarker of Coronary Artery Disease in Patients with Obstructive Sleep Apnea

Author

Katsumata, Yusuke, primary, Terada, Jiro, additional, Matsumura, Takuma, additional, Koshikawa, Ken, additional, Sakao, Seiichiro, additional, Tomiyoshi, Go, additional, Shinmen, Natsuko, additional, Nakamura, Rika, additional, Kuroda, Hideyuki, additional, Nagashima, Kengo, additional, Kobayashi, Yoshio, additional, Kobayashi, Eiichi, additional, Iwadate, Yasuo, additional, Zhang, Xiao-Meng, additional, Hiwasa, Takaki, additional, and Tatsumi, Koichiro, additional

Published
2020
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88. Ta-Coated Titanium Surface With Superior Bacteriostasis And Osseointegration

Author

Zhang,Xiao-Meng, Li,Yuan, Gu,Ying-Xin, Zhang,Chu-Nan, Lai,Hong-Chang, Shi,Jun-Yu, Zhang,Xiao-Meng, Li,Yuan, Gu,Ying-Xin, Zhang,Chu-Nan, Lai,Hong-Chang, and Shi,Jun-Yu

Abstract

Xiao-Meng Zhang,* Yuan Li,* Ying-Xin Gu, Chu-Nan Zhang, Hong-Chang Lai, Jun-Yu Shi Department of Implant Dentistry, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong-Chang Lai; Jun-Yu ShiDepartment of Implant Dentistry, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 500 Quxi Road, Shanghai 200011, People’s Republic of ChinaTel +86 21 23271699 (ext. 5298)Fax +86 21 53073068Email lhc9@hotmail.com; sakyamuni_jin@163.comBackground: Although tantalum (Ta)-based coatings have been proven to have good antibacterial activity, the underlying mechanism and in vivo biological performance remain unclear, which are essential for the clinical application of Ta-coated biomaterials as dental implants.Purpose: The main objective of this study is to investigate the antibacterial activity of Ta-modified titanium (Ti) implants against peri-implantitis-related microbes and the potential molecular mechanisms.Methods: Fusobacterium nucleatum and Porphyromonas gingivalis were selected to evaluate the antibacterial activity and potential antibacterial mechanism of Ta modification. The in vivo biocompatibility of Ta-modified implants was also evaluated.Results: The results showed that Ta-modified surface performed excellent antimicrobial activity against Fusobacterium nucleatum and Porphyromonas gingivalis. Micro galvanic might be formed between the incorporated Ta and the Ti base, which could consume the protons and result in decreased ATP synthesis and increased ROS generation. The gene expression of bacterial virulence factors associated with cellular attachment, invasion and viability as

Published
2019

89. Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

Author

Dutertre, Charles Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., Ginhoux, Florent, Dutertre, Charles Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., and Ginhoux, Florent

Published
2019

90. Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

Author

UMC Utrecht, Translationele immunologie, Infection & Immunity, CTI Radstake, Dutertre, Charles Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., Ginhoux, Florent, UMC Utrecht, Translationele immunologie, Infection & Immunity, CTI Radstake, Dutertre, Charles Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., and Ginhoux, Florent

Published
2019

91. Penetrating neck trauma caused by a rebar

Author

Wang, Yan, Sun, Yu, Zhou, Tao, Liu, Guo-hui, Zhang, Xiao-meng, Yue, Jian-xin, Xiong, Xin-gao, Liu, Bang-hua, Yang, Chen-Zhang, Kong, Weijia, and Wang, Yan-Jun

Subjects
Male, Postoperative Care, Wounds, Penetrating, Middle Aged, foreign body, Foreign Bodies, neck, penetrating trauma, Neck Injuries, Treatment Outcome, Image Processing, Computer-Assisted, Humans, Neck Dissection, Parotid Gland, Clinical Case Report, Tomography, X-Ray Computed, Research Article
Abstract

Rationale: Penetrating neck trauma has a mortality of 3% to 6% and is associated with serious complications, mainly due to the high density of vital structures in this area and the lack of corresponding protection from bone. Patient concerns: A 55-year-old man who suffered neck trauma involving the parotid gland, caused by a rebar, after suffering a fall from the second floor of a building. Diagnoses: Penetrating neck trauma. Interventions: The patient underwent a neck exploration under general anesthesia in the emergency operating room and tracheotomy was performed prophylactically. Outcomes: The foreign object was ultimately removed successfully with no complications. Lessons: We concluded that computed tomography (CT) and three-dimensional reconstruction of the CT images can be a viable method to exclude macrovascular injury for patients who are in an emergency condition and are not eligible for computed tomography angiography (CTA). A chest tube could be used as an option for the removal of foreign bodies in the case of sharp or rough objects (such as spiral foreign bodies), when fully exposing the foreign body and its track.

Published
2018

95. Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

Author

Dutertre, Charles-Antoine, primary, Becht, Etienne, additional, Irac, Sergio Erdal, additional, Khalilnezhad, Ahad, additional, Narang, Vipin, additional, Khalilnezhad, Shabnam, additional, Ng, Pei Y., additional, van den Hoogen, Lucas L., additional, Leong, Jing Yao, additional, Lee, Bernett, additional, Chevrier, Marion, additional, Zhang, Xiao Meng, additional, Yong, Pearly Jean Ai, additional, Koh, Geraldine, additional, Lum, Josephine, additional, Howland, Shanshan Wu, additional, Mok, Esther, additional, Chen, Jinmiao, additional, Larbi, Anis, additional, Tan, Henry Kun Kiaang, additional, Lim, Tony Kiat Hon, additional, Karagianni, Panagiota, additional, Tzioufas, Athanasios G., additional, Malleret, Benoit, additional, Brody, Joshua, additional, Albani, Salvatore, additional, van Roon, Joel, additional, Radstake, Timothy, additional, Newell, Evan W., additional, and Ginhoux, Florent, additional

Published
2019
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96. Association Analysis of Drought Tolerance and Associated Traits in Upland Cotton at the Seedling Stage

Author

Li, Hai-Ming, primary, Liu, Shao-Dong, additional, Ge, Chang-Wei, additional, Zhang, Xiao-Meng, additional, Zhang, Si-Ping, additional, Chen, Jing, additional, Shen, Qian, additional, Ju, Fei-Yan, additional, Yang, Yong-Fei, additional, Li, Yang, additional, Liu, Rui-Hua, additional, Ma, Hui-Juan, additional, Zhao, Xin-Hua, additional, Li, Cun-Dong, additional, and Pang, Chao-You, additional

Published
2019
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99. Issue Information ‐ IFC

Author

Li, Yuan, primary, Qiao, Shi‐Chong, additional, Gu, Ying‐Xin, additional, Zhang, Xiao‐Meng, additional, Shi, Jun‐Yu, additional, and Lai, Hong‐Chang, additional

Published
2019
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