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4,881 results on '"Zhou, Shu"'

66. Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition

Author

Jie Cao, Lanqin Li, Runge Zhang, Zhou Shu, Yaxin Zhang, Weiguang Sun, Yonghui Zhang, and Zhengxi Hu

Subjects
Neurodegenerative diseases, Narural products, Libertellenone C, NLRP3 inflammasome, Botany, QK1-989
Abstract

Abstract Neurodegenerative diseases (NDs) are common chronic diseases arising from progressive damage to the nervous system. Here, in-house natural product database screening revealed that libertellenone C (LC) obtained from the fermentation products of Arthrinium arundinis separated from the gut of a centipede collected in our Tongji campus, showed a remarkable neuroprotective effect. Further investigation was conducted to clarify the specific mechanism. LC dose-dependently reversed glutamate-induced decreased viability, accumulated reactive oxygen species, mitochondrial membrane potential loss, and apoptosis in SH-SY5Y cells. Network pharmacology analysis predicted that the targets of LC were most likely directly related to oxidative stress and the regulation of inflammatory factor-associated signaling pathways. Further study demonstrated that LC attenuated nitrite, TNF-α, and IL-1β production and decreased inducible nitric oxide synthase and cyclooxygenase expression in lipopolysaccharide-induced BV-2 cells. LC could directly inhibit NLRP3 inflammasome activation by decreasing the expression levels of NLRP3, ASC, cleaved Caspase-1, and NF-κB p65. Our results provide a new understanding of how LC inhibits the NLRP3 inflammasome in microglia, providing neuroprotection. These findings might guide the development of effective LC-based therapeutic strategies for NDs.

Published
2024
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87. Reliability Evaluation Method of Urban Distribution Network Power Supply Considering Automatic Partitioning of Distribution Network

Author

Zhou SHU, Wenfeng YANG, and Wei LIAO

Subjects
urban distribution network, distribution network planning, reliability assessment, distribution automation, analytical method, Energy industries. Energy policy. Fuel trade, HD9502-9502.5
Abstract

[Introduction] Under the current situation of increasing automation level of distribution network, in order to solve the problem that the influence of distribution automation is not considered in traditional distribution network power supply reliability assessment methods, in this paper, a method for rapid assessment of power supply reliability of urban distribution network is proposed, which takes into account the automatic partitioning of distribution network. [Method] In this paper, based on the node division method of path characteristics, by demarcating automatic partitioning of distribution network, defining large and small segments, a method for evaluating the effect of power supply reliability improvement that was suitable for automatic partitioning of distribution network was proposed. [Result] Compared with the industry standard for reliability evaluation of medium-voltage distribution network, the proposed method fully considers the influence of distribution automation on reducing fault location, isolation and switching operation time, and the evaluation result is reduced by about 22%. [Conclusion] The proposed method can more accurately analyze the power supply reliability of the distribution network with a higher level of distribution automation, and is suitable for urban distribution network areas with a small power outage time base.

Published
2023
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94. Prediction of Cancer Driver Genes Based on Pyramidal Dynamic Mapping Algorithm

Author

Wei, Pi-Jing, Zhou, Shu-Li, Cao, Rui-Fen, Su, Yansen, Zheng, Chun-Hou, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Huang, De-Shuang, editor, Premaratne, Prashan, editor, Jin, Baohua, editor, Qu, Boyang, editor, Jo, Kang-Hyun, editor, and Hussain, Abir, editor

Published
2023
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95. Determination of the Inputting Data Length for the Diagnosis of the Operation Trend Based on Wavelet Analysis

Author

Zhang, Wen-Ji, Zhou, Shu-Qiao, Li, Duo, Huang, Xiao-Jin, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Gu, Pengfei, editor, Xu, Yang, editor, Chen, Weihua, editor, Chen, Rigang, editor, Sun, Yongbin, editor, and Liu, Zheming, editor

Published
2023
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96. Behavior of Bamboo Scrimber Beam-Column Joints with Bolted Steel Angles and T-Stubs

Author

Xiong, Jun, Zhou, Shu-Rong, Kang, Shao-Bo, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Geng, Guoqing, editor, Qian, Xudong, editor, Poh, Leong Hien, editor, and Pang, Sze Dai, editor

Published
2023
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