76 results on '"Zhou, Yanqiu"'
Search Results
52. Water-soluble thiosemicarbazide-imidazole derivative as an efficient inhibitor protecting P110 carbon steel from CO2 corrosion.
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He, Yi, Yang, Ranran, Zhou, Yanqiu, Ma, Lan, Zhang, Lei, and Chen, Zhao
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CARBON steel , *CORROSION engineering , *IMIDAZOLES , *HYDROPHILIC compounds , *CARBON dioxide - Abstract
Purpose The purpose of this paper is to adopt both the fragments of imidazole and thiosemicarbazide as reaction centers, to synthesize a water-soluble corrosion inhibitor named as thiosemicarbazide-imidazole derivative (TH-IM).Design/methodology/approach This paper presents potentiodynamic polarization tests, electrochemical impedance spectroscopy tests and morphology study of metal surface by scanning electron microscope and thermodynamic study.Findings In the aggressive condition of CO2 saturated Wt. NaCl solution at 333 K for 72 h with 400 ppm inhibitor dosage, the efficiency of inhibition increases approximately 98 per cent through the method of weight loss.Originality/value This paper finds a new corrosion inhibitor about TH-IM which has a good solubility in water. [ABSTRACT FROM AUTHOR]
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- 2016
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53. DEVELOPMENT OF THE COPING STRATEGIES INVENTORY FOR TRAUMA COUNSELORS.
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Bober, Ted, Regehr, Cheryl, and Zhou, Yanqiu Rachel
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COUNSELING , *TRAUMATISM , *PSYCHOLOGICAL adaptation , *COUNSELORS , *GRIEF , *LOSS (Psychology) , *EMOTIONS , *PSYCHOLOGY - Abstract
There is increasing awareness about the negative consequences of counseling traumatized people. Emanating from qualitative research and clinical reflections, suggestions are frequently made regarding self-care strategies to reduce the impact. However, no tools exist for measuring these strategies to determine the effectiveness of engaging in self-care behaviors. This study evaluates the Coping Strategies Inventory which measures beliefs and behaviors regarding coping in trauma counselors. Items were derived from the practice literature and a focus group with experienced therapists. A factor analysis was conducted with a sample of 259 trauma therapists and 71 hospital workers. Results demonstrated a consistent factor structure with adequate internal reliability. The CSI may thus be useful in research on vicarious trauma and for self-appraisal of counselors. [ABSTRACT FROM AUTHOR]
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- 2006
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54. Trimester-specific and sex-specific effects of prenatal exposure to di(2-ethylhexyl) phthalate on fetal growth, birth size, and early-childhood growth: A longitudinal prospective cohort study.
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Li, Jiufeng, Qian, Xi, Zhou, Yanqiu, Li, Yuanyuan, Xu, Shunqing, Xia, Wei, and Cai, Zongwei
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- 2021
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55. Characteristics of exposure to multiple environmental chemicals among pregnant women in Wuhan, China.
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Chen, Huan, Zhang, Wenxin, Zhou, Yanqiu, Li, Jiufeng, Zhao, Hongzhi, Xu, Shunqing, Xia, Wei, Cai, Zongwei, and Li, Yuanyuan
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Previous studies on environmental pollutant exposure during pregnancy have mostly focused on individual chemical substances or single urine measurements. Thus, our understanding of the potential cumulative or interactive effects of exposure is limited. We aimed to ascertain the characteristics and predictors of exposure to environmental chemicals over three trimesters among pregnant women. We measured the concentrations of 34 chemicals in spot urine samples provided by 745 participants in their early, middle, and late pregnancy. We calculated Spearman correlation coefficients (SCC) between exposure levels of multiple chemicals in each trimester. K -means clustering and principal components analysis (PCA) were applied to classify the populations and reduce data dimensionality. We used generalized linear models (GLM) to confirm predictors of each cluster and principal component. SCC showed that the correlations of chemical concentrations from the same classes were higher than those among concentrations of different classes. Cluster analysis categorized participants into three clusters, and each cluster represented different chemical concentrations. We restricted the principal components to six, which explained more than 50% of the data variations. Several physiological, socio-demographic factors, and behavior patterns were related to different clusters and principal components. Distinct exposure patterns and dominant exposure components of multiple environmental chemicals among pregnant women might help research the potential health effects of exposure to chemical mixtures and develop relevant public health interventions. Unlabelled Image • We profiled the characteristics of exposure to multiple environmental chemicals over three trimesters among pregnant women. • K -means clustering classified participants into the metal, the phthalates, and the lower chemicals exposure group. • We identified metals, phthalates, and benzophenones as main exposure components of 34 chemicals with PCA. • Maternal age, parity, pre-pregnancy BMI, education levels, and job type were associated with mixed chemicals exposure. [ABSTRACT FROM AUTHOR]
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- 2021
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56. Trimester-specific exposure to triclocarban during pregnancy: Associations with oxidative stress and size at birth.
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Zhang, Hongna, Luo, Qiong, Hu, Chengchen, Song, Qian, Zhou, Yanqiu, Su, Xiuli, Li, Yuanyuan, Xia, Wei, Zheng, Yuxin, Xu, Shunqing, and Cai, Zongwei
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- 2024
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57. Nine phthalate metabolites in human urine for the comparison of health risk between population groups with different water consumptions.
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Li, Jiufeng, Zhao, Hongzhi, Xia, Wei, Zhou, Yanqiu, Xu, Shunqing, and Cai, Zongwei
- Abstract
Abstract Phthalates are a group of high production volume chemicals widely detected in environment matrix and human specimens. Potential health risks due to the prevalence of their exposure through water consumption and the endocrine-disrupting activities have become an important issue. This work aims to compare the distributions of phthalate levels and potential health risks caused by phthalate exposure among three groups of participants ingesting different types of water. Here, a method with good performance was applied for the analysis of nine common phthalate metabolites in 125 human urine samples collected from Wuhan women. Seven analytes (mono‑ethyl, mono‑benzyl, mono‑ n ‑butyl, mono‑(2‑ethylhexyl), mono‑(2‑ethyl‑5‑oxohexyl), mono‑(2‑ethyl‑5‑hydroxyhexyl), and mono‑(2‑ethyl‑5‑carboxypentyl) phthalate) were detected in over 80% of the samples. By measuring urinary concentrations of phthalate monoesters, the exposure levels of respective parent phthalates, exposure patterns, the estimated daily intakes and accumulative risk assessments were investigated in three groups of participants consuming water from different sources (bottled water, filtered water and boiled tap water). The results showed that the exposure patterns of phthalates varied among the population groups with different water intakes, and the health risk was higher for people ingesting the boiled tap water than that of the groups consuming bottled water (purified water) and filtered water with filter cartridge containing activated carbon. Graphical abstract Unlabelled Image Highlights • MnBP was the major phthalate metabolite in the studied populations. • DnBP in group drinking tap water was significantly higher than other two groups. • DiBP in tap water intake group was strongly higher than bottled water group. • DEHP in tap water group was much higher than that in filtered water group. • Population group drinking tap water had the highest health risk caused by PAEs [ABSTRACT FROM AUTHOR]
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- 2019
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58. Associations between repeated measures of maternal urinary phthalate metabolites during pregnancy and cord blood glucocorticoids.
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Sun, Xiaojie, Li, Jiufeng, Jin, Shuna, Li, Yuanyuan, Liu, Wenyu, Zhao, Hongzhi, Zhou, Yanqiu, Jiang, Yangqian, Liu, Hongxiu, Xia, Wei, Cai, Zongwei, Xu, Shunqing, and Shen, Xiantao
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CORD blood , *PHTHALATE esters , *PREGNANCY complications , *GLUCOCORTICOIDS , *CORTISONE - Abstract
Abstract Background Previous studies have suggested that phthalates might disrupt fetal steroidogenesis. However, the evidence of the effects of prenatal phthalate exposure across pregnancy on fetal glucocorticoids was insufficient. Objective We investigated the associations between urinary phthalate metabolites across pregnancy and cord blood glucocorticoids in a prospective birth cohort. Methods Our study included 553 mother-infant pairs from a prospective birth cohort conducted in Wuhan, China. Maternal urine samples were collected at 14, 24 and 36 weeks of gestation (mean). Urinary phthalate metabolites and cord blood glucocorticoids (cortisol and cortisone) were measured. Generalized estimating equation models were conducted to explore the relationships of phthalate metabolite concentrations at each trimester and glucocorticoid levels. Results Among the participants, mono‑benzyl phthalate (MBzP) in the first trimester was associated with higher cortisol/cortisone ratio concentrations, and mono‑(2‑ethyl‑5‑carboxypentyl) phthalate (MECPP) and mono‑(2‑ethyl‑5‑oxohexyl) phthalate (MEOHP) measured in the third trimester were associated with decreased cortisone. Moreover, the associations between phthalates and glucocorticoids varied by sex. Among the female infants, each 10-fold increase in several maternal urinary phthalate metabolite concentrations in 1st and 3rd trimester was associated with the increased glucocorticoid levels with percent changes ranged from 16.2%–55.9%. However, among male infants, each 10-fold increase in maternal urinary MECPP, mono‑(2‑ethyl‑5‑hydroxyhexyl) phthalate (MEHHP) and MEOHP in 3rd trimester was associated with 20.8%–36.3% decreased cortisol and cortisone levels, respectively. Conclusion We have shown that prenatal phthalate exposure during early and late trimester disrupted the infant steroidogenesis and these associations might be modified by infant sex. To the best of our knowledge, this is the first study to evaluate phthalate exposure at three trimesters during pregnancy in relation to infant glucocorticoids. Highlights • Association between maternal phthalate exposure during pregnancy and cord glucocorticoids was evaluated for the first time. • Prenatal phthalate exposure during early and late trimester might disrupt the fetal steroidogenesis. • Fetal sex might modify the relationship of phthalate exposure and glucocorticoid levels. [ABSTRACT FROM AUTHOR]
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- 2018
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59. Nano‐scaled and aggregated films to protect carbon steel from corrosion in hydrochloric acid.
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Ma, Lan, He, Yi, Luo, Pingya, Zhang, Liyun, Zhou, Yanqiu, and Zhang, Lei
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CARBON steel , *CORROSION & anti-corrosives , *HYDROCHLORIC acid , *DENDRIMERS , *RESPONSE inhibition - Abstract
An efficient corrosion inhibitor named BTA‐IM is reported in this contribution. The inhibition performance of BTA‐IM for carbon steel in 1 M HCl is investigated and the possible inhibition mechanism is proposed. According to weight‐loss experiments, the inhibition efficiency of BTA‐IM can reach to 98%. Secondly, the morphology investigation illustrates that the nano‐scaled, dendrimer‐like, and multi‐layer films cover the metal surface regularly and compactly through self‐assembly. Thirdly, the thickness of the films on surface of metal is gradually increased with the increasing dosage of inhibitor, and the aggregated films are obtained. Possibly, the aggregated films are born of absorption films and the increased concentration of BTA‐IM, giving rise to the regular and compact films. [ABSTRACT FROM AUTHOR]
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- 2018
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60. Social Work and Global Health Inequalities: Practice and Policy Developments - Edited by Paul Bywaters, Eileen McLeod and Lindsey Napier.
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Zhou, Yanqiu Rachel
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SOCIAL services , *NONFICTION - Abstract
The article reviews the book "Social Work and Global Inequalities: Practice and Policy Developments," edited by Paul Bywaters, Eileen McLeod, and Lindsey Napier.
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- 2011
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61. Urinary metabolomics revealed arsenic exposure related to metabolic alterations in general Chinese pregnant women.
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Li, Han, Wang, Mu, Liang, Qiande, Jin, Shuna, Sun, Xiaojie, Jiang, Yangqian, Pan, Xingyun, Zhou, Yanqiu, Peng, Yang, Zhang, Bin, Zhou, Aifen, Zhang, Yiming, Chen, Zhong, Cao, Jiangxia, Zhang, Hongling, Xia, Wei, Zheng, Tongzhang, Cai, Zongwei, Li, Yuanyuan, and Xu, Shunqing
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METABOLOMICS , *ARSENIC poisoning , *MATERNAL health , *BIOMARKERS , *HEALTH risk assessment - Abstract
Arsenic exposure is considered a major environmental threat to human health. It is already known that high-level arsenic exposure has adverse effects on human health. Since the pregnant women are known to be more susceptible to some chemical exposures than ordinary people, the understanding regarding the health effects of low-level arsenic exposure on pregnant women is critical and remains unclear. The aim of this study is to investigate the urinary metabolic changes of pregnant women exposed to low-dose arsenic, and to identify biomarkers from metabolomics analysis. Urine samples of 246 pregnant women were collected in the first trimester of pregnancy and were divided into three groups based on the tertile distribution of urinary arsenic concentrations which were determined using inductively coupled plasma mass spectrometry (ICP-MS). Changes in the metabolite profile were measured using ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF MS). Arsenic- related metabolic biomarkers were investigated by comparing the samples of the first and third tertiles of arsenic exposure classifications using a partial least-squares discriminant model (PLS-DA). Nine urine potential biomarkers were putatively identified, including LysoPC (14:0), glutathione, 18-carboxy-dinor-LTE4, 20-COOH-LTE4, cystathionine ketimin, 1-(beta- d -ribofuranosyl)-1,4-dihydronicotinamide, thiocysteine, p -cresol glucuronide and vanillactic acid. The obtained results showed that environmental arsenic exposure, even at low levels, could cause metabolite alterations in pregnant women which might be associated with adverse health outcomes. This is the first report on metabolic changes in pregnant women for arsenic exposure. The findings may be valuable for the arsenic risk assessment for pregnant women. [ABSTRACT FROM AUTHOR]
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- 2017
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62. Exploring the Intersection of Time and Globalization.
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Huebener, Paul, O'Brien, Susie, Porter, Tony, Stockdale, Liam, and Zhou, Yanqiu Rachel
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GLOBALIZATION , *MATERIALITY (Accounting) - Abstract
An introduction is presented in which the editor discusses various articles within the issue on topics including globalization in respect to financial and environmental crises, impact of materiality on globalization, and relationship between human consciousness of material rhythms and time.
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- 2016
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63. Maternal urinary manganese and risk of low birth weight: a case-control study.
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Wei Xia, Yanqiu Zhou, Tongzhang Zheng, Bin Zhang, Bassig, Bryan A., Yuanyuan Li, Wise Sr., John Pierce, Aifen Zhou, Yanjian Wan, Youjie Wang, Chao Xiong, Jinzhu Zhao, Zhengkuan Li, Yuanxiang Yao, Jie Hu, Xinyun Pan, Shunqing Xu, Xia, Wei, Zhou, Yanqiu, and Zheng, Tongzhang
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MATERNAL health , *URINALYSIS , *LOW birth weight , *PHYSIOLOGICAL effects of manganese , *EPIDEMIOLOGY , *HEALTH outcome assessment , *MANGANESE , *MATERNAL age , *RELATIVE medical risk , *CASE-control method , *ODDS ratio - Abstract
Background: Manganese (Mn) is an essential element for humans, but exposure to high levels has been associated with adverse developmental outcomes. Early epidemiological studies evaluating the effect of Mn on fetal growth are inconsistent.Methods: We investigated the association between maternal urinary Mn during pregnancy and the risk of low birth weight (LBW). Mn concentrations in maternal urine samples collected before delivery were measured in 816 subjects (204 LBW cases and 612 matched controls) recruited between 2012 and 2014 in Hubei Province, China.Results: The median Mn concentration in maternal urine was 0.69 μg/g creatinine. Compared to the medium tertile of Mn levels, an increased risk of LBW was observed for the lowest tertile (≤0.30 μg/g creatinine) [adjusted odds ratio (OR) = 1.28; 95 % confidence interval (CI) = 0.67, 2.45], and a significantly increased risk of LBW was observed for the highest tertile (≥1.16 μg/g creatinine) [adjusted OR = 2.04; 95 % CI = 1.12, 3.72]. A curvilinear relationship between maternal urinary Mn and risk of LBW was observed, showing that the concentration at 0.43 μg/g creatinine was the point of inflection. Similar associations were observed among the mothers with female infants and among the younger mothers < 28 years old. However, among the mothers with male infants or the older mothers ≥ 28 years old, only higher levels of Mn were positively associated with LBW.Conclusions: Lower or higher levels of maternal urinary Mn are associated with LBW, though only the association of LBW risk and higher levels of Mn was statistically significant. The findings also show that the associations may vary by maternal age and infant sex, but require confirmation in other populations. [ABSTRACT FROM AUTHOR]- Published
- 2016
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64. The inhibition performance of hydroxy lauric imidazoline for mild steel in chloride solution saturated with CO.
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Ma, Lan, He, Yi, Luo, PinYa, Zhan, Yingqing, Yang, RanRan, and Zhou, Yanqiu
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HYDROXY acids , *IMIDAZOLINES , *CHEMICAL synthesis , *IMIDAZOLES , *MILD steel , *ORTHOGONAL functions - Abstract
In the paper, a novel hydroxy lauric imidazoline (HL-IM) was synthesized using lauric acid and ethylene diamine as raw materials. Methanol reaction method was introduced to prepare the hydroxy lauric imidazoline (HL-IM). According to the results of experiments, the optimum synthesis conditions of methanol reaction was determined through orthogonal experiment, which were: methyl laurate: ethylene diamine = 1: 1, sodium methoxide (0.75 wt %), reaction temperature 100°C, reaction time 2 h. The inhibition efficiency of HL-IM inhibitor was investigated in the condition of 5 wt % NaCl solutions saturated with CO at 333.15 K for 72 h. With 150 mg L inhibitor dosage, the efficiency of inhibition reached 90.17% by weight loss method. Through film-forming property, foaming characteristic, and emulsification tendency test, it w a s shown that HL-IM had good water-solubility, a smaller emulsification tendency in 5 wt % NaCl solution, and a little foaming performance. Meanwhile, referring to the polarization curves tests, the synergistic effect of HL-IM with the potassium iodide, methylbutynol, and cetyltrimethyl ammonium bromide was studied. [ABSTRACT FROM AUTHOR]
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- 2016
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65. A case-control study of maternal exposure to chromium and infant low birth weight in China.
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Xia, Wei, Hu, Jie, Zhang, Bin, Li, Yuanyuan, Sr.Wise, John Pierce, Bassig, Bryan A., Zhou, Aifen, Savitz, David A., Xiong, Chao, Zhao, Jinzhu, du, Xiaofu, Zhou, Yanqiu, Pan, Xinyun, Yang, Jie, Wu, Chuansha, Jiang, Minmin, Peng, Yang, Qian, Zhengmin, Zheng, Tongzhang, and Xu, Shunqing
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LOW birth weight , *CHROMIUM in the body , *EPIDEMIOLOGY education , *URINALYSIS - Abstract
Exposure to chromium is increasing due to environmental pollution from industrial processes. Several epidemiological studies have investigated chromium exposure and reproductive outcomes, but few studies have investigated the association of chromium exposure and low birth weight (LBW). This study was designed to investigate whether maternal exposure to chromium during pregnancy is associated with an increased risk of LBW. Chromium concentrations in maternal urine samples collected at delivery were measured in 204 LBW cases and 612 matched controls recruited between 2012 and 2014 in Hubei Province, China. Risk of LBW was associated with higher levels of chromium in maternal urine [adjusted odds ratio (OR) = 1.77 for the medium tertile, 95% confidence interval (CI): 0.95, 3.29; adjusted OR = 2.48 for the highest tertile, 95% CI: 1.33, 4.61; P trend = 0.01]. The association was more pronounced among female infants (adjusted OR = 3.67 for the highest tertile, 95% CI: 1.50, 8.97) than among male infants (adjusted OR = 1.22 for the highest tertile, 95% CI = 0.48, 3.11) ( p heterogeneity = 0.06). Our findings suggest that maternal exposure to higher levels of chromium during pregnancy may potentially increase the risk of delivering LBW infants, particularly for female infants. [ABSTRACT FROM AUTHOR]
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- 2016
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66. An Evaluation of the Cobas4800 HPV Test on Cervico-Vaginal Specimens in Liquid versus Solid Transport Media.
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Luo, Hongxue, Du, Hui, Maurer, Kathryn, Belinson, Jerome L., Wang, Guixiang, Liu, Zhihong, Zhang, Lijie, Zhou, Yanqiu, Wang, Chun, Tang, Jinlong, Qu, Xinfeng, and Wu, Ruifang
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PAPILLOMAVIRUS disease diagnosis , *PAPILLOMAVIRUS diseases , *BIOLOGICAL transport , *CERVIX uteri , *PHASES of matter , *CERVICAL cancer diagnosis , *WOUNDS & injuries , *DISEASE risk factors - Abstract
Objectives: Determine the ability of the Cobas 4800 assay to detect high-risk human papillomavirus (HrHPV) and high-grade cervical lesions when using cervico-vaginal samples applied to liquid medium and solid media cards compared to a direct cervical sample. Methods: Two cervico-vaginal specimens (pseudo self-collected) were obtained from 319 women. One was applied to an iFTA Card (FTA) then the brush placed in liquid-based medium (LSELF); the other was applied to a new solid media: POI card (POI). The clinical performance of Cobas4800 assay using the three aforementioned specimens was compared to direct collected endocervical specimens in liquid media (LDOC). Results: The overall agreements of HrHPV detection were 84.2% (LSELF vs. LDOC), 81.0% (FTA vs. LDOC), and 82.3% (POI vs. LDOC). LSELF, FTA and POI identified 98.0%, 79.6%, and 97.5% positive cases of LDOC. Sensitivity to identify CIN2+ were 98.4% (LSELF), 73.8% (FTA), 95.1% (POI), and 93.4% (LDOC) respectively. FTA had 78.1% and 90.4% agreement with the LSELF samples for all HrHPV and HPV16/18 detection respectively, while POI had 91.6% for both. Conclusions: Cobas4800 HPV test combined with cervico-vaginal specimens applied to both liquid media and POI solid card are accurate to detect HrHPV infection and high-grade cervical lesions as compared with direct endocervical samples in liquid media. [ABSTRACT FROM AUTHOR]
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- 2016
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67. A Case-Control Study of Prenatal Thallium Exposure and Low Birth Weight in China.
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Xia, Wei, Du, Xiaofu, Zheng, Tongzhang, Zhang, Bin, Li, Yuanyuan, Bassig, Bryan A., Zhou, Aifen, Wang, Youjie, Xiong, Chao, Li, Zhengkuan, Yao, Yuanxiang, Hu, Jie, Zhou, Yanqiu, Liu, Juan, Xue, Weiyan, Ma, Yue, Pan, Xinyun, Peng, Yang, and Xu, Shunqing
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LOW birth weight , *CHI-squared test , *CONFIDENCE intervals , *STATISTICAL correlation , *INTERVIEWING , *PROBABILITY theory , *RESEARCH funding , *STATISTICS , *THALLIUM , *DATA analysis , *ENVIRONMENTAL exposure , *CASE-control method , *DATA analysis software , *DESCRIPTIVE statistics , *ODDS ratio , *MATERNAL exposure , *PREGNANCY - Abstract
BACKGROUND: Thallium (Tl) is a highly toxic heavy metal widely present in the environment. Case reports have suggested that maternal exposure to high levels of Tl during pregnancy is associated with low birth weight (LBW), but epidemiological data are limited. OBJECTIVES: This study was designed to evaluate whether prenatal Tl exposure is associated with an increased risk of LBW. METHODS: This case--control study involving 816 study participants (204 LBW cases and 612 matched controls) was conducted in Hubei Province, China, in 2012--2014. Tl concentrations were measured in maternal urine collected at delivery, and associations with LBW were evaluated using conditional logistic regression. RESULTS: Higher maternal urinary Tl levels were significantly associated with increased risk of LBW [crude odds ratio (OR) = 1.52; 95% CI: 1.00, 2.30 for the highest vs. lowest tertile], and the association was similarly elevated after adjustment for potential confounders (adjusted OR = 1.90; 95% CI: 1.01, 3.58 for the highest vs. lowest tertile). Stratified analyses showed slightly higher risk estimates for LBW associated with higher Tl levels for mothers < 28 years old and for mothers with lower household income; however, there was no statistical evidence of heterogeneity in risk according to maternal age (p for heterogeneity = 0.18) or household income (p for heterogeneity = 0.28). CONCLUSION: TO our knowledge, ours is the first case--control study to investigate the association between prenatal Tl exposure and LBW. The results suggest that prenatal exposure to high levels of Tl may be associated with an increased risk of LBW. [ABSTRACT FROM AUTHOR]
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- 2016
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68. Prenatal exposure to lead in relation to risk of preterm low birth weight: A matched case–control study in China.
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Zhang, Bin, Xia, Wei, Li, Yuanyuan, Bassig, Bryan A., Zhou, Aifen, Wang, Youjie, Li, Zhengkuan, Yao, Yuanxiang, Hu, Jie, Du, Xiaofu, Zhou, Yanqiu, Liu, Juan, Xue, Weiyan, Ma, Yue, Pan, Xinyun, Peng, Yang, Zheng, Tongzhang, and Xu, Shunqing
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LEAD toxicology , *LOW birth weight , *CREATININE , *PRENATAL exposure delayed effects , *REPRODUCTIVE toxicology ,RISK factors - Abstract
We investigated the association between prenatal exposure to lead (Pb) and the risk of preterm low birth weight (PLBW). Pb concentrations in maternal urine collected at birth from 408 subjects (102 cases and 306 matched controls) were analyzed and adjusted by creatinine. The median Pb concentration in the PLBW cases (10.60 μg Pb/g creatinine) was higher than that of the controls (7.28 μg Pb/g creatinine). An adjusted odds ratio (OR) of 2.96 (95% CI = 1.49–5.87) for PLBW was observed when the highest tertile was compared to the lowest tertile of Pb levels. The association was more pronounced among female infants (adjusted OR = 3.67 for the highest tertile; 95% CI = 1.35–9.93) than male infants (adjusted OR = 1.91 for the highest tertile; 95% CI = 0.74–4.95). Our study suggests that prenatal exposure to levels of Pb encountered today in China is associated with an elevated risk of PLBW. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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69. Spatial distribution, partitioning, and ecological risk of short chain chlorinated paraffins in seawater and sediment from East China Sea.
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Hu, Hongmei, Jin, Hangbiao, Li, Tiejun, Guo, Yuanming, Wu, Pengfei, Xu, Kaida, Zhu, Wenbin, Zhou, Yanqiu, and Zhao, Meirong
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- 2022
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70. Legacy and emerging poly- and perfluorochemicals in seawater and sediment from East China Sea.
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Hu, Hongmei, Zhang, Yingying, Zhao, Nan, Xie, Jiahui, Zhou, Yanqiu, Zhao, Meirong, and Jin, Hangbiao
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- 2021
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71. Detention of HPV L1 Capsid Protein and hTERC Gene in Screening of Cervical Cancer.
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Huang Bin, Wu Ruifang, Li Ruizhen, Liang Yiheng, Liu Zhihong, Li Juan, Wang Chun, Zhou Yanqiu, and Weng Leiming
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PAPILLOMAVIRUSES , *TELOMERASE , *CERVICAL cancer , *IMMUNOCYTOCHEMISTRY , *FLUORESCENCE in situ hybridization , *TISSUE wounds - Abstract
Objective(s): To investigate the expression of human papilloma virus (HPV) L1 capsid protein, and human telomerase RNA component (hTERC) in cervical cancer and the role of detection of both genes in screening of cervical cancer. Materials and Methods: A total of 309 patients were recruited and cervical exfoliated cells were collected. Immunocytochemistry was employed to detect HPV L1 capsid protein, and fluorescent in situ hybridization (FISH) was performed to detect the hTERC. Results: The expression of HPV L1 capsid protein reduced with the increase of the histological grade of cervical cells and was negatively related to the grade of cervical lesions. However, the expression of hTERC increased with the increase of the histological grade and positively associated with the grade of cervical lesions. The proportion of patients with L1(-)/hTERC(+) was higher in patients with histological grade of CIN2 or higher than that in those with histological grade of CIN1. The L1(+)/hTERC(-) and L1(-)/hTERC(-) were negatively related to the grade of cervical lesions. L1(-)/hTERC(+) was positively associated with the grade of cervical lesions. The L1/hTERC ratio increased. The negative predictive value of both HPV L1 and hTERC was higher than that of HPV L1 or hTERC, but there was no marked difference in the screening efficacy of cervical cancer among HPV L1, hTERC and HPV L1+hTERC. Conclusion: HPV L1 capsid protein and hTERC gene may serve as markers for the early diagnosis and prediction of cervical lesions. The increase in L1/hTERC ratio reflects the progression of cervical lesions to a certain extent. [ABSTRACT FROM AUTHOR]
- Published
- 2013
72. Prenatal exposure to bisphenol A and its alternatives and child neurodevelopment at 2 years.
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Jiang, Yangqian, Li, Jiufeng, Xu, Shunqing, Zhou, Yanqiu, Zhao, Hongzhi, Li, Yuanyuan, Xiong, Chao, Sun, Xiaojie, Liu, Hongxiu, Liu, Wenyu, Peng, Yang, Hu, Chen, Cai, Zongwei, and Xia, Wei
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NEURAL development , *BISPHENOL A , *COGNITIVE development , *INFANT development , *CHILD development - Abstract
• Associations of bisphenol exposure with child neurodevelopment were assessed. • The higher BPS levels were associated with lower PDI scores in boys, but not girls. • Second-trimester BPA concentrations were inversely associated with MDI scores. • Prenatal BPF exposure was not significantly associated with child neurodevelopment. While increasing evidence has shown that prenatal bisphenol A (BPA) exposure is adversely associated with child neurodevelopment, little is known about the neurodevelopmental effects of BPA alternatives, such as bisphenol S (BPS) and bisphenol F (BPF). We aimed to evaluate the relationships of repeated measurements of bisphenol exposure during pregnancy with child neurodevelopment. From 2014–2015, 456 mother-child pairs were included in the present study. Each had a spot urine sample in the first, second, and third trimester, respectively, during pregnancy for BPA, BPS, and BPF measurements. Children's neurodevelopment was assessed using the Bayley Scales of Infant Development at 2 years. In adjusted models, children's psychomotor development index scores decreased across quartiles of BPS concentrations [-5.52 (95 % CI: -10.06, -0.99) in the 4th quartile vs. 1 st quartile, P -trend = 0.01]. Each 10-fold increase in BPA concentrations was related to lower mental development index scores only in the second trimester [-2.87 (95 % CI: -4.98, -0.75), P trimester-int = 0.04]. However, prenatal BPF exposure was not significantly associated with child neurodevelopment. We provide evidence that prenatal exposure to BPA and BPS may affect child neurodevelopment. [ABSTRACT FROM AUTHOR]
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- 2020
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73. Trimester-specific, gender-specific, and low-dose effects associated with non-monotonic relationships of bisphenol A on estrone, 17β-estradiol and estriol.
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Li, Jiufeng, Zhang, Wenxin, Zhao, Hongzhi, Zhou, Yanqiu, Xu, Shunqing, Li, Yuanyuan, Xia, Wei, and Cai, Zongwei
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BISPHENOL A , *SEX hormones , *THIRD trimester of pregnancy , *PREGNANT women , *FETUS , *PREGNANCY in animals - Abstract
• Non-monotonic relationships between BPA and estrogen were noted among mothers. • Gender-specific associations of BPA with estrogen were observed. • Trimester-specific associations between BPA and estrogen were observed. • BPA was non-linearly associated with estrogen even under the safety threshold. Bisphenol A (BPA) may cause some adverse effects on human health by mimicking estrogen activities. In vitro and animal studies have observed the non-monotonic associations between BPA and natural estrogens, but the evidence in human study is lacking, particularly at multiple points in time during pregnancy. We aimed to examine the relationships between BPA and estrogens in the three trimesters among Chinese pregnant women and their gender variations. This study included 851 participants from a birth cohort conducted in Wuhan, China between 2014 and 2015. We measured concentrations of BPA and three estrogens (estrone (E1), 17β-estradiol (E2) and estriol (E3)) in urine samples collected in the three trimesters of pregnancy (mean for each visit: 13.0, 23.6, and 35.9 weeks' gestation). We calculated the estimated daily intakes using urinary BPA concentrations and compared them with the tolerable intake value to assess potential health risks. We used multivariate linear regression models stratified by trimester and gender to explore trimester-specific and gender-specific associations of BPA with E1, E2, and E3. We found the decreased levels of estrogens (β < 0, P < 0.05) in the upper BPA quartiles over three trimesters, except for the elevated levels of E3 (β = 0.20, 95% CI: 0.02, 0.38) in the highest BPA quartile in the 2nd trimester. There were significant non-linear associations (overall associations P < 0.05, non-linear associations P < 0.05) between BPA and E3 in the three trimesters. In the gender-stratified analysis, we observed significant negative relationships (β < 0, P < 0.05) between BPA and E2 among mothers carrying male fetuses in the 1st trimester and significant associations between BPA and E3 among mothers carrying female fetuses in the 2nd trimester. However, we found no significant relationship between BPA and E2 among mothers carrying female fetuses over three trimesters. Our findings support experimental evidence of non-monotonic relationships between BPA and three major estrogens, even at low doses of BPA. Mothers delivering male fetuses may be more sensitive to E2 at early pregnancy, and those delivering female fetuses may be more susceptive to E3 at mid-pregnancy. [ABSTRACT FROM AUTHOR]
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- 2020
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74. Bisphenol A and bisphenol S exposures during pregnancy and gestational age – A longitudinal study in China.
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Huang, Sha, Li, Jiufeng, Xu, Shunqing, Zhao, Hongzhi, Li, Yuanyuan, Zhou, Yanqiu, Fang, Jing, Liao, Jiaqiang, Cai, Zongwei, and Xia, Wei
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BISPHENOL A , *GESTATIONAL age , *DURATION of pregnancy , *PREGNANT women , *LONGITUDINAL method , *PREGNANCY , *SECOND trimester of pregnancy - Abstract
Bisphenol A (BPA) and its substitute bisphenol S (BPS) are endocrine-disrupting chemicals and metabolized rapidly in human body. BPA exposure in late pregnancy has been suggested to be associated with preterm birth (PTB), but the associations of trimester BPA and BPS exposures with gestational age have been rarely studied. We aimed to examine maternal urinary BPA and BPS levels longitudinally measured across pregnancy in relation to gestational age and PTB. A prenatal cohort study was conducted between 2014 and 2015 in Wuhan, China. Maternal urinary BPA and BPS concentrations were measured in a complete series of urine samples collected in the 1st, 2nd and 3rd trimesters from 850 pregnant women and corrected by specific gravity. In comparison with the lowest tertile of maternal urinary BPA, higher levels of averaged BPA concentration across pregnancy was associated with a 1.97-day decrease in gestation (95% CI: 3.25, −0.68) and an adjusted odds ratio of 3.19 (95% CI: 1.00, 10.45) for PTB. Higher BPA concentrations in three trimesters were also negatively associated with gestational age and positively correlated with PTB. In contrast, only a positive association of third-trimester BPS with gestational age was found, but the significant association disappeared in the adjusted models. Both maternal trimester and averaged BPA exposure across pregnancy were significantly associated with shortened gestation and increased risk of PTB. However, the results showed little evidence of a relationship between BPS and PTB. • Urinary BPA and BPS were measured in each trimester from 850 pregnant women. • Both trimester and averaged BPA exposure were associated with decreased gestation. • BPA exposure was related to increased risk of preterm birth (PTB) across pregnancy. • BPS exposure across pregnancy was not related to pregnancy duration or PTB. [ABSTRACT FROM AUTHOR]
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- 2019
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75. Prenatal exposure to phthalates and neurocognitive development in children at two years of age.
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Qian, Xi, Li, Jiufeng, Xu, Shunqing, Wan, Yanjian, Li, Yuanyuan, Jiang, Yangqian, Zhao, Hongzhi, Zhou, Yanqiu, Liao, Jiaqiang, Liu, Hongxiu, Sun, Xiaojie, Liu, Wenyu, Peng, Yang, Hu, Chen, Zhang, Bin, Lu, Shi, Cai, Zongwei, and Xia, Wei
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PHTHALATE esters , *TODDLERS development , *CHILD development , *INFANT development , *ENDOCRINE disruptors , *COGNITIVE development , *COGNITION in children , *HUMAN body - Abstract
Phthalates are a family of endocrine disruptors with short elimination half-lives in the human body. To date, few epidemiological studies have examined repeated measures of maternal urinary phthalates and the combined effects of prenatal exposure to multiple phthalates on children's neurocognitive development. We aimed to investigate the association between children's neurocognitive development at 2 years of age and prenatal phthalate exposure, as assessed by repeated measurements during pregnancy, and to further examine the effects of co-exposure to multiple phthalates using cumulative risk assessment. Within a prenatal cohort in Wuhan, China, we measured five high-molecular-weight (HMW) phthalates and three low-molecular-weight (LMW) phthalate metabolites' concentrations in three urine samples collected in the 1st, 2nd, and 3rd trimester of pregnancy from each mother. We assessed neurocognitive development by Bayley Scales of Infant and Toddler Development (BSID) at 2 years of age (n = 476) to obtain the children's mental development index (MDI) and psychomotor development index (PDI). Higher exposure levels to LMW phthalates compared to HMW phthalates were observed in our population. Ln-transformed averaged concentration of mono- n -butyl phthalate (MnBP), a metabolite of the LMW phthalate di- n -butyl phthalate (DnBP) during pregnancy, was associated with decreased PDI scores in all children (β = −1.90, 95% CI: −3.43, −0.37). Similarly, the averaged sum concentration of ∑dibutyl phthalate (∑DBP) was associated with decreased PDI scores in all children (β = −1.89, 95% CI: −3.63, −0.15). A negative trend of association between exposure to HMW phthalates and PDI scores was observed in girls, while a positive association was found in boys. In cumulative risk assessment analyses, we consistently observed that the hazard quotient of DnBP (the parent compound of MnBP) was inversely associated with PDI scores in all children, whereas the hazard quotient of di-2-ethylhexyl phthalate (DEHP), an HMW phthalate, was positively associated with PDI scores in boys only. This study is the first to use repeated measurement of maternal urinary phthalates in all three trimesters to assess prenatal exposure in relation to children's neurodevelopment. Our study suggested a negative association between prenatal exposure to MnBP and children's psychomotor development, and potentially sex-specific associations between HMW phthalates and neurocognitive development among boys and girls. These findings warrant further confirmation. • We first evaluated the effect of repeated measurements of maternal urinary phthalates on child neurocognitive development. • Prenatal exposure to mono-n-butyl phthalate was negatively associated with children's psychomotor development. • The sex-specific effect may exist between phthalates and neurocognitive development. [ABSTRACT FROM AUTHOR]
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- 2019
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76. Curative effect of 1.88-mg and 3.75-mg gonadotrophin-releasing hormone agonist on stage III-IV endometriosis: Randomized controlled study.
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Tang, Huiru, Wu, Ruifang, Li, Xiaohong, Zhou, Yanqiu, Liu, Zhihong, Wang, Chun, Chen, Yun, and Zhang, Fangting
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GONADOTROPIN releasing hormone , *COMPARATIVE studies , *CLINICAL drug trials , *DYSMENORRHEA , *ENDOMETRIOSIS , *ESTRADIOL , *ESTROGEN , *FOLLICLE-stimulating hormone , *SEX hormones , *LAPAROSCOPIC surgery , *LUTEINIZING hormone , *STATISTICAL sampling , *PERIMENOPAUSE , *BONE density , *RANDOMIZED controlled trials , *DESCRIPTIVE statistics , *THERAPEUTICS - Abstract
Aim To compare the therapeutic effect of 1.88-mg and 3.75-mg gonadotrophin-releasing hormone agonist (GnRHa) in the treatment of stage III-IV endometriosis after laparoscopic surgery. Methods Fifty patients with stage III-IV endometriosis diagnosed on laparoscopy were randomized into two groups according to GnRHa dose. Sex hormone level, symptoms of estrogen deficiency and lumbar vertebrae bone density were compared and analyzed between the two groups. Results Bone density was decreased in both groups at 20 weeks after treatment, and the degree of bone density loss in the full-dose group (5.6%) was higher than in the half-dose group (1.2%; P < 0.05). Surgery combined with the 3.75-mg GnRHa or with the 1.88-mg GnRHa relieved the degree of dysmenorrhea, although one case of light dysmenorrhea occurred in each group, but there was no significant difference ( P > 0.05) after resumption of menstruation. Both groups had symptoms of perimenopause at 8 weeks after treatment ( P > 0.05), but change in Kupperman score with time differed between the groups. At 16, 20 weeks after treatment, the symptoms of perimenopause in the half-dose group were improved, and Kupperman score was lower than at 8 weeks after treatment. In the full-dose group, however, Kupperman score was higher than at 8 weeks after treatment and higher than in the half-dose group ( P < 0.05). After treatment, follicle-stimulating hormone and luteinizing hormone both decreased in both groups ( P < 0.05), but there was no difference between the two groups ( P > 0.05). Estradiol (E2) in the full-dose group was significantly lower than in the half-dose group ( P < 0.05). Conclusion The 1.88-mg GnRHa treatment can be used in III-IV endometriosis patients after laparoscopic surgery, to reduce perimenopausal symptoms, significantly improve bone loss, and achieve a good clinical effect. [ABSTRACT FROM AUTHOR]
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- 2017
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