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60. FR-HIT Overview

Author

Niu, Beifang, primary, Zhu, Zhengwei, additional, Fu, Limin, additional, and Wu, Sitao, additional

Published
2014
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62. Exome sequencing identifies SLC17A9 pathogenic gene in two Chinese pedigrees with disseminated superficial actinic porokeratosis

Author

Cui, Hongzhou, Li, Longnian, Wang, Wenjun, Shen, Jie, Yue, Zhen, Zheng, Xiaodong, Zuo, Xianbo, Liang, Bo, Gao, Min, Fan, Xing, Yin, Xianyong, Shen, Changbing, Yang, Chao, Zhang, Change, Zhang, Xiaoguang, Sheng, Yujun, Gao, Jinping, Zhu, Zhengwei, Lin, Da, Zhang, Anping, Wang, Zaixing, Liu, Shengxiu, Sun, Liangdan, Yang, Sen, Cui, Yong, and Zhang, Xuejun

Published
2014
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64. Collective resistance intention of migrants to resettlement policies: the role of influential pathways of information sources.

Author

Liu, Yingying, Zhu, Zhe, Kapucu, Naim, Zhu, Zhengwei, and Guo, Xuesong

Subjects
IMMIGRANTS, INFORMATION resources
Abstract

The failure of large-scale resettlement policies has been largely determined by the collective resistance of residents. For migrants who must leave their original residence and get resettled, mass media and interpersonal communication are important sources to get policy information, which affects their attitudes and responses to resettlement policies. Existing studies have provided two pathways to explain the influencing mechanism between information sources and people's collective resistance intention. One of these pathways focuses on trust in government and the other highlights perceived benefits. However, it is still unclear how to predict migrants' collective resistance intention based on different information sources within these two pathways. By concentrating on the policy domain of Chinese resettlement projects, this study aims to develop an integrated, theoretical framework to explore the causal paths between information sources and migrants' collective resistance intention. Based on a survey of three towns in Ankang, China, we tested the causal mechanism with a structural equation model. The results demonstrate that the pathway that involves trust in government is more explanatory in illustrating the causal mechanism than the pathway of perceived benefits, and interpersonal communication yields stronger effects than mass media in mitigating migrants' collective resistance intention. The implications for resettlement policy publicity and trust-building in China are discussed. Points for practitioners: Public communication is a critical competency for public managers. Public managers are recommended to flexibly apply various information sources to communicate with migrants in order to eventually mitigate their collective resistance intention by strengthening their trust in government, as well as their perceived benefits. In the early stages of policy publicity, a variety of mass media are needed to inform the migrants of resettlement policies. Then, at the stage of policy implementation, the primary focus becomes interpersonal communication that offers sufficiently detailed information. In this regard, local government managers should carry out more programs that entail face-to-face information sharing to help participants understand the resettlement policy, and encourage them to explain it to their family and friends. [ABSTRACT FROM AUTHOR]

Published
2022
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66. Bach2 overexpression represses Th9 cell differentiation by suppressing IRF4 expression in systemic lupus erythematosus

Author

Sheng, Yujun, primary, Zhang, Jiali, additional, Li, Keke, additional, Wang, Hongyan, additional, Wang, Wenjun, additional, Wen, Leilei, additional, Gao, Jinping, additional, Tang, Xianfa, additional, Tang, Huayang, additional, Huang, He, additional, Cai, Minglong, additional, Yuan, Tao, additional, Liu, Lu, additional, Zheng, Xiaodong, additional, Zhu, Zhengwei, additional, and Cui, Yong, additional

Published
2020
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75. Association of the Polymorphism rs13259960 inSLEARWith Predisposition to Systemic Lupus Erythematosus

Author

Fan, Zhen, primary, Chen, Xiaowei, additional, Liu, Lu, additional, Zhu, Caihong, additional, Xu, Jinhua, additional, Yin, Xianyong, additional, Sheng, Yujun, additional, Zhu, Zhengwei, additional, Wen, Leilei, additional, Zuo, Xianbo, additional, Zheng, Xiaodong, additional, Zhang, Yaohua, additional, Xu, Jingkai, additional, Huang, He, additional, Zhou, Fusheng, additional, Sun, Liangdan, additional, Luo, Jianjun, additional, Zhang, Dongdong, additional, Chen, Xiaomin, additional, Cui, Ya, additional, Hao, Yajing, additional, Cui, Yong, additional, Zhang, Xuejun, additional, and Chen, Runsheng, additional

Published
2020
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78. Simulation and Analysis for Overlapping Probability of ADS-B 1090ES Signal

Author

Chu Kaibin, Feng Chengtao, Zhu Zhengwei, and Zhu Dong

Subjects
symbols.namesake, Duty cycle, Computer science, Air traffic management, symbols, Co-channel interference, Field (mathematics), Time domain, Poisson distribution, Algorithm, Signal, Incidence (geometry)
Abstract

As one of the three important ADS-B data-links, 1090ES has been widely used in the surveillance field of air traffic management. Since the radio channel of 1090ES signal is the same with the response signal of airborne responder of SSR, two kinds of signals often overlap in time domain in busy airspaces. High overlapping probability results in the problem that the 1090ES signal cannot be correctly decoded. The overlapping probability should be considered in the construction solution of ADS-B ground receiver station. In order to estimate the overlapping probability, we perform Monte-Carlo simulation by assuming random arrival time for all signals in unit time. Through the analysis on the simulation results, it is found that an average incidence coefficient has a linear relationship with a duty ratio coefficient. Based on the linear relationship and classic Poission distribution, a mathematic model is built to estimate the overlapping probability.

Published
2018

79. Disaster policy and emergency management reforms in China: From Wenchuan earthquake to Jiuzhaigou earthquake

Author

Kapucu Naim, Zhu Zhengwei, Xiangnan Hu, and Shi Jia

Subjects
021110 strategic, defence & security studies, 010504 meteorology & atmospheric sciences, Social network, Emergency management, business.industry, 0211 other engineering and technologies, Geology, Emergency management system, 02 engineering and technology, Geotechnical Engineering and Engineering Geology, Disaster response, 01 natural sciences, Emergency response, Policy learning, Business, China, Safety Research, Environmental planning, 0105 earth and related environmental sciences
Abstract

The article addresses policy changes and reforms in emergency management system in China comparing two major earthquakes. The Wenchuan earthquake in 2008 helped to uncover problems with the Chinese emergency management system. Almost a decade later, the Jiuzhaigou earthquake in 2017 also mobilized a national disaster response. These two major disasters provided opportunities to analyze changes in the disaster policy of China. This study adopted policy text and social network analyses to compare the emergency response plans used for both earthquakes. Policy learning and administrative reforms, including changes in the local disaster response organizations and emergency support functions, of local emergency management practices after the Wenchuan earthquake were highlighted. At the local level, the interorganizational collaboration network was better coordinated in 2017. The findings suggest some improvements for the disaster policies and practices of the local governments of China.

Published
2021

80. JAK2 and PTPRC mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

Author

Qian, Danfeng, primary, Liu, Lu, additional, Zhu, Tingting, additional, Wen, Leilei, additional, Zhu, Zhengwei, additional, Yin, Xianyong, additional, Qiu, Ying, additional, Wu, Mingshun, additional, Li, Xueying, additional, Ma, Jie, additional, Zhang, Qun, additional, Jin, Ling, additional, Wang, Xiaomeng, additional, Xu, Qiaohu, additional, Yang, Sen, additional, Sheng, Yujun, additional, Zhang, Shengquan, additional, and Zhang, Xuejun, additional

Published
2019
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86. Bach2 overexpression represses Th9 cell differentiation by suppressing IRF4 expression in systemic lupus erythematosus.

Author

Sheng, Yujun, Zhang, Jiali, Li, Keke, Wang, Hongyan, Wang, Wenjun, Wen, Leilei, Gao, Jinping, Tang, Xianfa, Tang, Huayang, Huang, He, Cai, Minglong, Yuan, Tao, Liu, Lu, Zheng, Xiaodong, Zhu, Zhengwei, and Cui, Yong

Subjects
SYSTEMIC lupus erythematosus, CELL differentiation, T cells, BLOOD cells, AUTOIMMUNE diseases
Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by abnormal activation of T cells and caused by an imbalance in the production and clearance of apoptotic cells. We previously showed that the transcription regulator Bach2 regulated abnormal B‐cell activation in SLE. Here, we investigated whether Bach2 was also involved in Th9 cell differentiation in SLE. We found that the proportion of Th9 cells was enhanced in the peripheral blood mononuclear cells (PBMC) of SLE patients. The PBMC and CD4+ T cells of SLE patients exhibited a decrease of Bach2 expression and an increase of IL‐9 expression. Furthermore, Bach2 overexpression significantly repressed the levels of PU.1, IRF4, IL‐9, and Th9 cells in the CD4+ T cells of SLE patients and healthy volunteers. In addition, Bach2 overexpression inhibited the levels of IL‐9 and Th9 cells, whereas IRF4 upregulation enhanced the levels of IRF4 and IL‐9 and Th9 cells in the CD4+ T cells of SLE patients and healthy volunteers. The effect of IRF4 up‐regulation was abolished by Bach2 overexpression. In summary, our work suggests that Bach2 overexpression represses Th9 cell differentiation by suppressing IRF4 expression in SLE, and thus, Bach2 may be a novel potential target for SLE treatment. [ABSTRACT FROM AUTHOR]

Published
2021
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87. Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.

Author

Fan, Zhen, Chen, Xiaowei, Liu, Lu, Zhu, Caihong, Xu, Jinhua, Yin, Xianyong, Sheng, Yujun, Zhu, Zhengwei, Wen, Leilei, Zuo, Xianbo, Zheng, Xiaodong, Zhang, Yaohua, Xu, Jingkai, Huang, He, Zhou, Fusheng, Sun, Liangdan, Luo, Jianjun, Zhang, Dongdong, Chen, Xiaomin, and Cui, Ya

Subjects
RNA metabolism, APOPTOSIS, CARRIER proteins, GENETIC polymorphisms, GENOMES, INTERLEUKINS, MOLECULAR biology, POLYMERASE chain reaction, SURVEYS, SYSTEMIC lupus erythematosus, PHENOTYPES, SINGLE nucleotide polymorphisms, DESCRIPTIVE statistics, MONONUCLEAR leukocytes, ODDS ratio, GENOTYPES, DISEASE risk factors
Abstract

Objective: Genome‐wide association studies have identified many susceptibility loci for systemic lupus erythematosus (SLE). However, most of these loci are located in noncoding regions of the genome. Long noncoding RNAs (lncRNAs) are pervasively expressed and have been reported to be involved in various diseases. This study aimed to explore the genetic significance of lncRNAs in SLE. Methods: A genome‐wide survey of SLE risk variants in lncRNA gene loci was performed in Han Chinese subjects (4,556 with SLE and 9,451 healthy controls). The functional relevance of an SLE risk variant in one of the lncRNA genes was explored using biochemical and molecular cell biology analyses. In vitro loss‐of‐function and gain‐of‐function strategies were used to clarify the functional and phenotypic relevance of this SLE susceptibility lncRNA. Moreover, correlation of this lncRNA with the degree of apoptosis in the peripheral blood of SLE patients was evaluated. Results: A novel SLE susceptibility locus in a lncRNA gene, designated SLEAR (for SLE‐associated RNA), was identified at the single‐nucleotide polymorphism rs13259960 (odds ratio 1.35, Pcombined = 1.03 × 10−11). The A>G variation at rs13259960, located in an intronic enhancer, was found to impair STAT1 recruitment to the enhancer that loops to the SLEAR promoter, resulting in decreased SLEAR production in peripheral blood mononuclear cells from patients with SLE (3 with the G/G genotype, 22 with A/G, and 103 with A/A at rs13259960; P = 0.0241). Moreover, SLEAR interacted with the RNA binding proteins interleukin enhancer binding factor 2, heterogeneous nuclear RNP F, and TATA‐binding protein–associated factor 15, to form a complex for transcriptional activation of the downstream antiapoptotic genes. In addition, SLEAR regulated apoptosis of Jurkat cells in vitro, and its expression level was correlated with the degree of cell death in the peripheral blood of patients with SLE (r = 0.824, P = 2.15 × 10−8; n = 30). Conclusion: These findings suggest a mechanism by which the risk variant at rs13259960 modulates SLEAR expression and confers a predisposition to SLE. Taken together, these results may give insights into the etiology of SLE. [ABSTRACT FROM AUTHOR]

Published
2020
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88. The association of the UHRF1BP1 gene with systemic lupus erythematosus was replicated in a Han Chinese population from mainland China.

Author

Wen, Leilei, Liu, Lu, Shen, Xue, Li, Hui, Zhu, Zhengwei, Huang, He, Cai, Minglong, Qian, Danfeng, Shen, Songke, Qiu, Ying, Cui, Yong, and Sheng, Yujun

Subjects
CHINESE people, SYSTEMIC lupus erythematosus, GENES, GENE expression, SINGLE nucleotide polymorphisms
Abstract

Single‐nucleotide polymorphisms (SNPs) in the UHRF gene have been shown to be associated with systemic lupus erythematosus (SLE) in European and Hong Kong Chinese, but statistically significant evidence for association has not been found in a mainland Han Chinese population. Therefore, we selected SNP rs13205210 located in UHRF1BP1 as a candidate association from our previously published genome‐wide association study (GWAS) data of SLE (1,047 cases and 1,205 controls from a mainland Han Chinese population) to explore the association between the UHRF1BP1 gene and SLE. We conducted a large‐scale replication study in an additional independent sample of 3,509 cases and 8,246 controls from a mainland Han Chinese population. Real‐time PCR was used to determine gene expression differences in peripheral blood mononuclear cells (PBMCs) from cases and controls. As a result, we replicated the association between the UHRF1BP1 gene and SLE (rs13205210, missense, Pmeta = 2.26E‐17, odds ratio = 1.41) by a meta‐analysis of our previous GWAS and this replication study involving a total of 4,556 cases and 9,451 controls. The UHRF1BP1 mRNA expression level in PBMCs was significantly decreased in patients with SLE compared with that in healthy controls. SNP rs13205210 exhibited an expression quantitative trait loci effect on the UHRF1BP1 gene in PBMCs from patients. In conclusion, this study not only suggests that the UHRF1BP1 gene was associated with SLE in a mainland Han Chinese population, but also implied that it might be a common genetic factor contributing to SLE susceptibility in multiple populations. [ABSTRACT FROM AUTHOR]

Published
2020
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89. RETRACTED: NFKB1 mediates Th1/Th17 activation in the pathogenesis of psoriasis

Author

Zhou, Fusheng, primary, Zhu, Zhengwei, additional, Gao, Jinping, additional, Yang, Chao, additional, Wen, Leilei, additional, Liu, Lu, additional, Zuo, Xianbo, additional, Zheng, Xiaodong, additional, Shi, Yinjuan, additional, Zhu, Caihong, additional, Liang, Bo, additional, Yin, Xianyong, additional, Wang, Wenjun, additional, Cheng, Hui, additional, Shen, Songke, additional, Tang, Xianfa, additional, Tang, Huayang, additional, Sun, Liangdan, additional, Zhang, Anping, additional, Yang, Sen, additional, Zhang, Xuejun, additional, and Sheng, Yujun, additional

Published
2018
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90. Human proteins that interact with RNA/DNA hybrids

Author

Wang, Isabel X., primary, Grunseich, Christopher, additional, Fox, Jennifer, additional, Burdick, Joshua, additional, Zhu, Zhengwei, additional, Ravazian, Niema, additional, Hafner, Markus, additional, and Cheung, Vivian G., additional

Published
2018
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91. Identification of ST3AGL4, MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning

Author

Wang, Yong-Fei, primary, Zhang, Yan, additional, Zhu, Zhengwei, additional, Wang, Ting-You, additional, Morris, David L, additional, Shen, Jiangshan Jane, additional, Zhang, Huoru, additional, Pan, Hai-Feng, additional, Yang, Jing, additional, Yang, Sen, additional, Ye, Dong-Qing, additional, Vyse, Timothy J, additional, Cui, Yong, additional, Zhang, Xuejun, additional, Sheng, Yujun, additional, Lau, Yu Lung, additional, and Yang, Wanling, additional

Published
2018
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92. RETRACTED: Bach2 regulates aberrant activation of B cell in systemic lupus erythematosus and can be negatively regulated by BCR-ABL/PI3K

Author

Zhu, Zhengwei, primary, Yang, Chao, additional, Wen, Leilei, additional, Liu, Lu, additional, Zuo, Xianbo, additional, Zhou, Fusheng, additional, Gao, Jinping, additional, Zheng, Xiaodong, additional, Shi, Yinjuan, additional, Zhu, Caihong, additional, Liang, Bo, additional, Yin, Xianyong, additional, Wang, Wenjun, additional, Cheng, Hui, additional, Shen, Songke, additional, Tang, Xianfa, additional, Tang, Huayang, additional, Sun, Liangdan, additional, Zhang, Anping, additional, Yang, Sen, additional, Cui, Yong, additional, Zhang, Xuejun, additional, and Sheng, Yujun, additional

Published
2018
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93. Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters

Author

Grunseich, Christopher, primary, Wang, Isabel X., additional, Watts, Jason A., additional, Burdick, Joshua T., additional, Guber, Robert D., additional, Zhu, Zhengwei, additional, Bruzel, Alan, additional, Lanman, Tyler, additional, Chen, Kelian, additional, Schindler, Alice B., additional, Edwards, Nancy, additional, Ray-Chaudhury, Abhik, additional, Yao, Jianhua, additional, Lehky, Tanya, additional, Piszczek, Grzegorz, additional, Crain, Barbara, additional, Fischbeck, Kenneth H., additional, and Cheung, Vivian G., additional

Published
2018
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94. Increased expression of PRKCB mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

Author

Zhu, Zhengwei, primary, Yang, Lulu, additional, Zhang, Yaohua, additional, Liu, Lu, additional, Huang, Yan, additional, Wen, Leilei, additional, Yang, Chao, additional, Chen, Liyun, additional, Wang, Wenjun, additional, Zuo, Xianbo, additional, Zhou, Fusheng, additional, Wang, Hongyan, additional, Tang, Huayang, additional, Zhang, Xuejun, additional, Yang, Sen, additional, Sheng, Yujun, additional, and Cui, Yong, additional

Published
2018
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97. Workpiece Posture Measurement and Intelligent Robot Grasping Based on Monocular Vision

Author

Guo Qingda, Zhu Zhengwei, and Quan Yanming

Subjects
Engineering, Robot kinematics, Monocular, business.industry, 010401 analytical chemistry, Feature extraction, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Corner detection, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Edge detection, 0104 chemical sciences, Robot control, Robot, Computer vision, Artificial intelligence, 0210 nano-technology, business, Monocular vision
Abstract

Industrial robots have been widely applied in grasping static workpieces, but the measurement method for the three-dimensional position of known specifications and random location of online workpieces still cannot meet the application requirements of the industrial field. In this paper, system structure and installation design of hardware were introduced firstly. Then, image pre-processing and feature extraction were established, composing of image enhancement, image smooth, edge detection, corner detection and angle calculation. Finally, a monocular vision-guided robot grasping device platform was established as well as corresponding software control platform. Experimental results indicated that the monocular vision system could quickly identify the workpiece pose with high measurement accuracy and that the robot could successfully grasp random location workpieces.

Published
2016

99. Genotype combination contributes to psoriasis: An exhaustive algorithm perspective

Author

Dou, Jinfa, primary, Guo, Huimin, additional, Cheng, Fang, additional, Huang, Hequn, additional, Fu, Liying, additional, Li, Longnian, additional, Yang, Chao, additional, Ye, Lei, additional, Wen, Leilei, additional, Cheng, Yuyan, additional, Tang, Lili, additional, Zhu, Caihong, additional, Zhu, Zhengwei, additional, Wang, Wenjun, additional, Sheng, Yujun, additional, Wang, Zaixing, additional, Liu, Shengxiu, additional, Fan, Xing, additional, Zuo, Xianbo, additional, Zhou, Fusheng, additional, Sun, Liangdan, additional, Zheng, Xiaodong, additional, and Zhang, Xuejun, additional

Published
2017
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