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52. Gastroenterology

Author

van Bodegraven, A.A., van Weyenberg, S.J.B., Wierdsma, N.J., De Wit, N.J., and Brouwers, J.R.B.J.

Published
2011

53. Disease burden of post-infectious irritable bowel syndrome in The Netherlands

Author

Haagsma, J.A., Siersema, P.D., de Wit, N.J., Havelaar, A.H., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Public Health, Gastroenterology & Hepatology, Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS

Subjects
medicine.medical_specialty, Epidemiology, Campylobacteriosis, Disease, Medical sciences, Irritable Bowel Syndrome, Risk Factors, Internal medicine, medicine, Humans, Bescherming en bevordering van de menselijke gezondheid, Geneeskunde(GENK), Irritable bowel syndrome, Disease burden, Netherlands, Econometric and Statistical Methods: General, business.industry, Incidence, Incidence (epidemiology), Bacterial Infections, medicine.disease, General [Econometric and Statistical Methods], Gastroenteritis, Surgery, Quality-adjusted life year, Infectious Diseases, Attributable risk, Quality of Life, Quality-Adjusted Life Years, business
Abstract

SUMMARYPost-infectious irritable bowel syndrome (PI-IBS) has been established as a sequel of infectious intestinal disease (IID). The aim of this study was to estimate the burden of PI-IBS caused by the pathogens Campylobacter, Salmonella and Shigella, and to compare this with other outcomes associated with these pathogens. The attributable risk of PI-IBS due to bacterial pathogens was calculated and linked to national data on gastroenteritis incidence and measures for severity and duration of illness in order to estimate the burden of PI-IBS. One year post-infection, IBS developed in 9% of patients with bacterial IID. The burden of PI-IBS adds over 2300 disability adjusted life years to the total annual disease burden for the selected pathogens. PI-IBS is a frequent sequel of IID, resulting in a considerable disease burden compared to other outcomes. If this relationship is not considered, this will result in an underestimation of the disease burden of IID.

Published
2010

54. Oplosbare of niet-oplosbare vezels: Wat werkt beter bij het prikkelbaredarm-syndroom?

Author

Bijkerk, C.J., de Wit, N.J., Muris, J., Whorwell, P.J., J.A. Knottnerus, prof.dr., and Hoes, A.W.

Subjects
Econometric and Statistical Methods: General, Geneeskunde (GENK), Bescherming en bevordering van de menselijke gezondheid, Geneeskunde(GENK), Medical sciences, General [Econometric and Statistical Methods]
Published
2010

57. Zuurremmers: hoog inzetten, of juist laag? Het DIAMOND-onderzoek naar effectiviteit en kosten van de step-up en de step-downbenadering bij maagklachten in de eerste lijn

Author

van Marrewijk, C.J., Mujakovic, S., Fransen, G.A., Numans, M.E., de Wit, N.J., Muris, J.W.M., van Oijen, M.G.H., Jansen, J.B., Grobbee, D.E., Knottnerus, J.A., and Laheij, R.J.F.

Subjects
Genomic disorders and inherited multi-system disorders [IGMD 3], Molecular epidemiology [NCEBP 1], Molecular gastro-enterology and hepatology [IGMD 2]
Abstract

Contains fulltext : 79806.pdf (Publisher’s version ) (Closed access)

Published
2009

61. Relative risk of irritable bowel syndrome following acute gastroenteritis and associated risk factors

Author

Risk Assessment of Toxic and Immunomodulatory Agents, LS IRAS VPH MBR (microbiol.risico sch.), Dep IRAS, IRAS RATIA2, Kowalcyk, B.K., Smeets, H.M., Succop, P.A., de Wit, N.J., Havelaar, A.H., Risk Assessment of Toxic and Immunomodulatory Agents, LS IRAS VPH MBR (microbiol.risico sch.), Dep IRAS, IRAS RATIA2, Kowalcyk, B.K., Smeets, H.M., Succop, P.A., de Wit, N.J., and Havelaar, A.H.

Published
2014

62. Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice – an evidence-based international guide

Author

Hungin, A.P., Mulligan, C., Pot, B., Whorwell, P., Agréus, L., Fracasso, P., Lionis, C., mendive, J, Philipart de Foy, J.M., Rubin, G., Winchester, C., de Wit, N.J., Hungin, A.P., Mulligan, C., Pot, B., Whorwell, P., Agréus, L., Fracasso, P., Lionis, C., mendive, J, Philipart de Foy, J.M., Rubin, G., Winchester, C., and de Wit, N.J.

Published
2013

63. Self-management : one size does not fit all

Author

Trappenburg, J.C.A., Jonkman, N.H., Jaarsma, T., van Os-Medendorp, H., Kort, H., de Wit, N.J., Hoes, A.W., Schuurmans, M.J., Trappenburg, J.C.A., Jonkman, N.H., Jaarsma, T., van Os-Medendorp, H., Kort, H., de Wit, N.J., Hoes, A.W., and Schuurmans, M.J.

Published
2013

70. Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice – an evidence-based international guide

Author

JC Overig onderzoek, Cancer, General Practice & Nursing Science, Hungin, A.P., Mulligan, C., Pot, B., Whorwell, P., Agréus, L., Fracasso, P., Lionis, C., mendive, J, Philipart de Foy, J.M., Rubin, G., Winchester, C., de Wit, N.J., JC Overig onderzoek, Cancer, General Practice & Nursing Science, Hungin, A.P., Mulligan, C., Pot, B., Whorwell, P., Agréus, L., Fracasso, P., Lionis, C., mendive, J, Philipart de Foy, J.M., Rubin, G., Winchester, C., and de Wit, N.J.

Published
2013

71. Analytical performance, agreement and user-friendliness of five C-reactive protein point-of-care tests

Author

Brain, Circulatory Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, JC Overig onderzoek, Cancer, General Practice & Nursing Science, Epidemiology & Health Economics, Minnaard, M.C., van de Pol, A.C., Broekhuizen, B.D.L., Verheij, Th.J.M., Hopstaken, R.M., van Delft, S., Kooijman-Buiting, A.M., de Groot, J.A.H., de Wit, N.J., Brain, Circulatory Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, JC Overig onderzoek, Cancer, General Practice & Nursing Science, Epidemiology & Health Economics, Minnaard, M.C., van de Pol, A.C., Broekhuizen, B.D.L., Verheij, Th.J.M., Hopstaken, R.M., van Delft, S., Kooijman-Buiting, A.M., de Groot, J.A.H., and de Wit, N.J.

Published
2013

72. Exploring the expectations, needs and experiences of general practitioners and nurses towards a proactive and structured care programme for frail older patients: a mixed-methods study

Author

Brain, JC Overig onderzoek, Other research (not in main researchprogram), Cancer, General Practice & Nursing Science, Revalidatie/Sportgeneeskunde Medisch, Bleijenberg, N., ten Dam, V.H., Steunenberg, B., Drubbel, I., Numans, M.E., de Wit, N.J., Schuurmans, M.J., Brain, JC Overig onderzoek, Other research (not in main researchprogram), Cancer, General Practice & Nursing Science, Revalidatie/Sportgeneeskunde Medisch, Bleijenberg, N., ten Dam, V.H., Steunenberg, B., Drubbel, I., Numans, M.E., de Wit, N.J., and Schuurmans, M.J.

Published
2013

73. Multidisciplinaire richtlijn Polyfarmacie bij ouderen

Author

JC Overig onderzoek, Cancer, General Practice & Nursing Science, MS Geriatrie, Verduijn, M., Leendertse, A., Moeselaar, A., de Wit, N.J., van Marum, R.J., JC Overig onderzoek, Cancer, General Practice & Nursing Science, MS Geriatrie, Verduijn, M., Leendertse, A., Moeselaar, A., de Wit, N.J., and van Marum, R.J.

Published
2013

74. Referrals for recurrent respiratory tract infections including otitis media in young children.

Author

Child Health, Infection & Immunity, JC Overig onderzoek, JC onderzoeksprogramma Methodologie, Other research (not in main researchprogram), Cancer, General Practice & Nursing Science, Longziekten, Zorgeenheid KNO Medisch, Epidemiology & Health Economics, Cardiometabolic Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Data Science & Biostatistiek, van de Pol, A.C., van der Gugten, A.C., van der Ent, C.K., Schilder, A.G.M., Benthem, E.M., Smit, H.A., Stellato, R.K., de Wit, N.J., Damoiseaux, R.A.M.J., Child Health, Infection & Immunity, JC Overig onderzoek, JC onderzoeksprogramma Methodologie, Other research (not in main researchprogram), Cancer, General Practice & Nursing Science, Longziekten, Zorgeenheid KNO Medisch, Epidemiology & Health Economics, Cardiometabolic Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Data Science & Biostatistiek, van de Pol, A.C., van der Gugten, A.C., van der Ent, C.K., Schilder, A.G.M., Benthem, E.M., Smit, H.A., Stellato, R.K., de Wit, N.J., and Damoiseaux, R.A.M.J.

Published
2013

75. Multidisciplinaire richtlijn prikkelbaredarmsyndroom

Author

JC Overig onderzoek, Cancer, General Practice & Nursing Science, Woutersen-Koch, H., Smout, A.J., Flik, C.E., Hulshof, C.T., de Wit, N.J., van der Horst, H.E., JC Overig onderzoek, Cancer, General Practice & Nursing Science, Woutersen-Koch, H., Smout, A.J., Flik, C.E., Hulshof, C.T., de Wit, N.J., and van der Horst, H.E.

Published
2013

76. Application of the Rome III criteria is not likely to reduce the number of unnecessary referrals for colonoscopy in primary care.

Author

JC onderzoeksprogramma Kanker, JC Overig onderzoek, JC onderzoeksprogramma Methodologie, Cancer, General Practice & Nursing Science, Epidemiology & Health Economics, Kok, L., Elias, S.G., Witteman, B.J., Goedhard, J.G., Romberg-Camps, M.J., Muris, JW, Moons, K.G.M., de Wit, N.J., JC onderzoeksprogramma Kanker, JC Overig onderzoek, JC onderzoeksprogramma Methodologie, Cancer, General Practice & Nursing Science, Epidemiology & Health Economics, Kok, L., Elias, S.G., Witteman, B.J., Goedhard, J.G., Romberg-Camps, M.J., Muris, JW, Moons, K.G.M., and de Wit, N.J.

Published
2013

77. Samenvatting van de NHG-Standaard Maagklachten

Author

JC Overig onderzoek, Cancer, General Practice & Nursing Science, de Jongh, E., Numans, M.E., de Wit, N.J., Heemstra-Borst, C.G., Geijer, R., Burgers, J.S., JC Overig onderzoek, Cancer, General Practice & Nursing Science, de Jongh, E., Numans, M.E., de Wit, N.J., Heemstra-Borst, C.G., Geijer, R., and Burgers, J.S.

Published
2013

78. Gastroprotective strategies in chronic NSAID users: A cost-effectiveness analysis comparing single-tablet formulations with individual components.

Author

Infection & Immunity, JC Overig onderzoek, Cancer, MS MDL 1, General Practice & Nursing Science, de Groot, N.L., Spiegel, B.M., van Haalen, H.G., de Wit, N.J., Siersema, P.D., van Oijen, M.G.H., Infection & Immunity, JC Overig onderzoek, Cancer, MS MDL 1, General Practice & Nursing Science, de Groot, N.L., Spiegel, B.M., van Haalen, H.G., de Wit, N.J., Siersema, P.D., and van Oijen, M.G.H.

Published
2013

79. Identifying frailty: do the Frailty Index and Groningen Frailty Indicator cover different clinical perspectives? a cross-sectional study

Author

JC Overig onderzoek, Other research (not in main researchprogram), Cancer, General Practice & Nursing Science, Revalidatie/Sportgeneeskunde Medisch, Drubbel, I., Bleijenberg, N., Kranenburg, G., Eijkemans, R.J., Schuurmans, M.J., de Wit, N.J., Numans, M.E., JC Overig onderzoek, Other research (not in main researchprogram), Cancer, General Practice & Nursing Science, Revalidatie/Sportgeneeskunde Medisch, Drubbel, I., Bleijenberg, N., Kranenburg, G., Eijkemans, R.J., Schuurmans, M.J., de Wit, N.J., and Numans, M.E.

Published
2013

80. Self-management: one size does not fit all

Author

Infection & Immunity, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC Overig onderzoek, Cancer, Revalidatie/Sportgeneeskunde Medisch, MS Dermatologie/Allergologie, General Practice & Nursing Science, Epidemiology & Health Economics, Trappenburg, J.C.A., Jonkman, N.H., Jaarsma, T., van Os-Medendorp, H., Kort, H., de Wit, N.J., Hoes, A.W., Schuurmans, M.J., Infection & Immunity, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC Overig onderzoek, Cancer, Revalidatie/Sportgeneeskunde Medisch, MS Dermatologie/Allergologie, General Practice & Nursing Science, Epidemiology & Health Economics, Trappenburg, J.C.A., Jonkman, N.H., Jaarsma, T., van Os-Medendorp, H., Kort, H., de Wit, N.J., Hoes, A.W., and Schuurmans, M.J.

Published
2013

81. Culturally sensitive care for elderly immigrants through ethnic community health workers: design and development of a community based intervention programme in the Netherlands

Author

JC onderzoeksprogramma Kanker, JC Overig onderzoek, Other research (not in main researchprogram), Cancer, General Practice & Nursing Science, Bioethics & Health Humanities, Verhagen, I., Ros, W.J.G., Steunenberg, B., de Wit, N.J., JC onderzoeksprogramma Kanker, JC Overig onderzoek, Other research (not in main researchprogram), Cancer, General Practice & Nursing Science, Bioethics & Health Humanities, Verhagen, I., Ros, W.J.G., Steunenberg, B., and de Wit, N.J.

Published
2013

82. Screening op dikkedarmkanker: doen!

Author

JC Overig onderzoek, Cancer, General Practice & Nursing Science, de Wit, N.J., JC Overig onderzoek, Cancer, General Practice & Nursing Science, and de Wit, N.J.

Published
2013

84. Patient adherence to prescribed medication instructions for dyspepsia: the DIAMOND-study

Author

Fransen, G.A.J., Mesters, I., Muris, J.W.M., Marrewijk, C.J. van, Mujakovic, S., Laheij, R.J.F., Numans, M.E., de Wit, N.J., Samsom, M., Jansen, J.B.M.J., Knottnerus, J.A., Fransen, G.A.J., Mesters, I., Muris, J.W.M., Marrewijk, C.J. van, Mujakovic, S., Laheij, R.J.F., Numans, M.E., de Wit, N.J., Samsom, M., Jansen, J.B.M.J., and Knottnerus, J.A.

Abstract

Contains fulltext : 108978.pdf (Publisher’s version ) (Closed access), BACKGROUND: Insight into patient adherence is needed to enable an effect evaluation of medication for dyspepsia. OBJECTIVES: Adherence was explored by investigating two adherence outcome measures (completeness and intake fidelity) using data from the DIAMOND-study. METHODS: The DIAMOND-study is a pragmatic RCT comparing a 'step-up' with a 'step-down' treatment strategy. In step 1 participants (n =653) were instructed to use five pills/day for maximally 30 days: an antacid 4dd plus a placebo 1dd ('step-up') or a proton pump inhibitor 1dd plus a placebo 4dd ('step-down'). If the complaints persisted, step 2 was started (H(2)-receptor antagonist 2dd), and subsequently step 3 (five pills/day, placebo and verum vice versa from step 1). Completeness was assessed by pill counts, intake fidelity by patient questionnaires measuring the degree to which patients adhered to specific instructions concerning timing, frequency, dose and way of intake. RESULTS: In step 1, patients used on average 3.9 pills/day (78% of the prescribed doses), in step 2, 1.7 pills/day (85%) and in step 3, 3.6 pills/day (72%). For the four times daily pills, half of the patients used less than 80% of the prescribed pills per day. This was one third of the patients for the twice daily pills and one quarter for the once daily pills. There were no completeness differences between active or placebo medication and no differences between the study arms. As regards intake fidelity, 70% of the patients made one or more errors in the medication intake. CONCLUSION: There is room for improvement in adherence rates for dyspepsia medication.

Published
2012

85. Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice

Author

Steegenga, W.T., de Wit, N.J., Boekschoten, M.V., Ijssennagger, N., Lute, C., Keshtkar, S., Bromhaar, M.M., Kampman, E., de Groot, L.C., Muller, M., Steegenga, W.T., de Wit, N.J., Boekschoten, M.V., Ijssennagger, N., Lute, C., Keshtkar, S., Bromhaar, M.M., Kampman, E., de Groot, L.C., and Muller, M.

Abstract

Contains fulltext : 109613.pdf (publisher's version ) (Open Access), BACKGROUND: By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the functional decline associated with aging is still under debate. METHODS: Young (4 M) and old (21 M) male C57BL/6J mice were fed a control low-fat (10E%) or a high-fat diet (45E%) for 2 weeks. During the intervention gross energy intake and energy excretion in the feces were measured. After sacrifice the small and large intestine were isolated and the small intestine was divided in three equal parts. Swiss rolls were prepared of each of the isolated segments for histological analysis and the luminal content was isolated to examine alterations in the microflora with 16S rRNA Q-PCR. Furthermore, mucosal scrapings were isolated from each segment to determine differential gene expression by microarray analysis and global DNA methylation by pyrosequencing. RESULTS: Digestible energy intake was similar between the two age groups on both the control and the high-fat diet. Microarray analysis on RNA from intestinal scrapings showed no marked changes in expression of genes involved in metabolic processes. Decreased expression of Cubilin was observed in the intestine of 21-month-old mice, which might contribute to aging-induced vitamin B12 deficiency. Furthermore, microarray data analysis revealed enhanced expression of a large number of genes involved in immune response and inflammation in the colon, but not in the small intestine of the 21-month-old mice. Aging-induced global hypomethylation was observed in the colon and the distal part of the small intestine, but not in the first two sections of the small intestine. CONCLUSION: In 21-month old mice the most pronounced effects of aging were observed in the colon, whereas very few changes were observed in the small intestine.

Published
2012

86. Plasma mannose-binding lectin is stimulated by PPARalpha in humans

Author

Rakhshandehroo, M., Stienstra, R., de Wit, N.J., Bragt, M.C., Haluzik, M., Mensink, R.P., Muller, M., Kersten, S., Rakhshandehroo, M., Stienstra, R., de Wit, N.J., Bragt, M.C., Haluzik, M., Mensink, R.P., Muller, M., and Kersten, S.

Abstract

Item does not contain fulltext, The peroxisome proliferator activated receptor-alpha (PPARalpha) is a major transcriptional regulator of lipid metabolism in liver and represents the molecular target for hypolipidemic fibrate drugs. Effects of PPARalpha on lipid metabolism are partially mediated by circulating proteins such as FGF21 and ANGPTL4. The present study was undertaken to screen for and identify circulating proteins produced by human liver that are under the control of PPARalpha. Toward that aim, primary human hepatocytes were treated with the synthetic PPARalpha agonist Wy-14643 and whole genome expression data selected for secreted proteins. Expression of FGF21, ANGPTL4, and mannose-binding lectin (MBL), a soluble mediator of innate immunity and primary component of the lectin branch of the complement system, was markedly upregulated by Wy-14643 in primary human hepatocytes. Mice express two MBL isomers, Mbl1 and Mbl2. Mbl1 mRNA was weakly induced by Wy-14643 in primary mouse hepatocytes and remained unaltered by Wy-14643 in mouse liver. Mbl2 mRNA was unchanged by Wy-14643 in primary mouse hepatocytes and was strongly reduced by Wy-14643 in mouse liver. Remarkably, plasma Mbl1 levels were increased by chronic PPARalpha activation in lean and obese mice. Importantly, in two independent clinical trials, treatment with the PPARalpha agonist fenofibrate at 200 mg/day for 6 wk and 3 mo increased plasma MBL levels by 73 (P = 0.0016) and 86% (P = 0.017), respectively. It is concluded that hepatocyte gene expression and plasma levels of MBL are stimulated by PPARalpha and fenofibrate in humans, linking PPARalpha to regulation of innate immunity and complement activation in humans and suggesting a possible role of MBL in lipid metabolism.

Published
2012

87. Oit1/Fam3D, a gut-secreted protein displaying nutritional status-dependent regulation

Author

de Wit, N.J., Ijssennagger, N., Oosterink, E., Keshtkar, S., Hooiveld, G.J., Mensink, R.P., Hammer, S., Smit, J.W.A., Muller, M., der Meer, R., de Wit, N.J., Ijssennagger, N., Oosterink, E., Keshtkar, S., Hooiveld, G.J., Mensink, R.P., Hammer, S., Smit, J.W.A., Muller, M., and der Meer, R.

Abstract

Item does not contain fulltext, Oncoprotein-induced transcript 1 (Oit1) was previously identified as a dietary fat-induced gene in the small intestine of C57Bl/6J mice. In this study, we further characterized Oit1 and its human ortholog family with sequence similarity 3, member D (Fam3D), on the messenger RNA as well as the protein level. Oit1 and Fam3D were found to be predominantly expressed in the gastrointestinal tract of mice and humans, respectively. Dietary fat induced a clear and acute up-regulation of Oit1, especially in the jejunum, whereas fasting led to a reduced gene expression in the small intestine. Regarding protein expression, we found a remarkable pattern of Oit1 along the longitudinal axis of the intestine, a predominant villus-restricted expression in the proximal small intestine and a more pronounced crypt expression in the distal parts of the intestine. Using transfection experiments, we confirmed secretion of the Oit1 protein, as was predicted by a signal peptide sequence. Detection of Oit1 and Fam3D in plasma samples indicated that both proteins are secreted to the basolateral site of enterocytes. Moreover, in human plasma samples, we also found an effect of nutritional status on Fam3D levels, with a postprandial elevation and a reduction after fasting. In conclusion, Oit1 and Fam3D are gut-derived proteins that are expressed and secreted in a nutritional status-dependent manner.

Published
2012

88. Computerondersteunde zorg bij hart- en vaatziekten

Author

Brain, JC Overig onderzoek, Cancer, General Practice & Nursing Science, de Wit, N.J., Brain, JC Overig onderzoek, Cancer, General Practice & Nursing Science, and de Wit, N.J.

Published
2012

89. Follow-up of mild alanine aminotransferase elevation identifies hidden hepatitis C in primary care

Author

Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, JC Overig onderzoek, Other research (not in main researchprogram), Cancer, General Practice & Nursing Science, JC onderzoeksprogramma Cancer, Helsper, C.W., van Essen, G.A., Frijling, B.D., de Wit, N.J., Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, JC Overig onderzoek, Other research (not in main researchprogram), Cancer, General Practice & Nursing Science, JC onderzoeksprogramma Cancer, Helsper, C.W., van Essen, G.A., Frijling, B.D., and de Wit, N.J.

Published
2012

90. Proactive and integrated primary care for frail older people: Design and methodological challenges of the Utrecht Primary care PROactive Frailty Intervention Trial (U-PROFIT)

Author

Brain, JC Overig onderzoek, Other research (not in main researchprogram), General Practice & Nursing Science, Revalidatie/Sportgeneeskunde Medisch, Bleijenberg, N., Drubbel, I., ten Dam, V.H., Numans, M.E., Schuurmans, M.J., de Wit, N.J., Brain, JC Overig onderzoek, Other research (not in main researchprogram), General Practice & Nursing Science, Revalidatie/Sportgeneeskunde Medisch, Bleijenberg, N., Drubbel, I., ten Dam, V.H., Numans, M.E., Schuurmans, M.J., and de Wit, N.J.

Published
2012

94. Oplosbare of niet-oplosbare vezels: Wat werkt beter bij het prikkelbaredarm-syndroom?

Author

Brain, Circulatory Health, Cancer, General Practice & Nursing Science, Epidemiology & Health Economics, Bijkerk, C.J., de Wit, N.J., Muris, J., Whorwell, P.J., J.A. Knottnerus, prof.dr., Hoes, A.W., Brain, Circulatory Health, Cancer, General Practice & Nursing Science, Epidemiology & Health Economics, Bijkerk, C.J., de Wit, N.J., Muris, J., Whorwell, P.J., J.A. Knottnerus, prof.dr., and Hoes, A.W.

Published
2010

97. Effect and cost-effectiveness of step-up versus step-down treatment with antacids, H2-receptor antagonists, and proton pump inhibitors in patients with new onset dyspepsia (DIAMOND study): a primary-care-based randomised controlled trial.

Author

van Marrewijk, C.J., Mujakovic, S., Fransen, G.A., Numans, M.E., de Wit, N.J., Muris, JW, van Oijen, M.G.H., Jansen, J.B., Grobbee, D.E., Knottnerus, J.A., Laheij, R.J.F., van Marrewijk, C.J., Mujakovic, S., Fransen, G.A., Numans, M.E., de Wit, N.J., Muris, JW, van Oijen, M.G.H., Jansen, J.B., Grobbee, D.E., Knottnerus, J.A., and Laheij, R.J.F.

Published
2009

98. Early recognition of heart failure in patients with diabetes type 2 in primary care. A prospective diagnostic efficiency study. (UHFO-DM2).

Author

Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, General Practice & Nursing Science, Cardiologie, Healthcare Innovation & Evaluation, Epidemiology & Health Economics, Boonman-de Winter, L.J.M., Rutten, F.H., Cramer, M.J.M., Liem, A.H., Landman, M.J., van Stel, H.F., de Wit, N.J., Rutten, G.E.H.M., Hessen, P.A.W., Hoes, A.W., Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, General Practice & Nursing Science, Cardiologie, Healthcare Innovation & Evaluation, Epidemiology & Health Economics, Boonman-de Winter, L.J.M., Rutten, F.H., Cramer, M.J.M., Liem, A.H., Landman, M.J., van Stel, H.F., de Wit, N.J., Rutten, G.E.H.M., Hessen, P.A.W., and Hoes, A.W.

Published
2009

99. Effect and cost-effectiveness of step-up versus step-down treatment with antacids, H2-receptor antagonists, and proton pump inhibitors in patients with new onset dyspepsia (DIAMOND study): a primary-care-based randomised controlled trial.

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC Overig onderzoek, Revalidatie/Sportgeneeskunde Medisch, General Practice & Nursing Science, Epidemiology & Health Economics, van Marrewijk, C.J., Mujakovic, S., Fransen, G.A., Numans, M.E., de Wit, N.J., Muris, JW, van Oijen, M.G.H., Jansen, J.B., Grobbee, D.E., Knottnerus, J.A., Laheij, R.J.F., Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC Overig onderzoek, Revalidatie/Sportgeneeskunde Medisch, General Practice & Nursing Science, Epidemiology & Health Economics, van Marrewijk, C.J., Mujakovic, S., Fransen, G.A., Numans, M.E., de Wit, N.J., Muris, JW, van Oijen, M.G.H., Jansen, J.B., Grobbee, D.E., Knottnerus, J.A., and Laheij, R.J.F.

Published
2009

100. Glucocorticosteroids associated with a decreased risk of psychosis.

Author

JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epidemiology & Health Economics, General Practice & Nursing Science, Onderzoek, Laan, W., Smeets, H, de Wit, N.J., Kahn, R.S., Grobbee, D.E., Burger, H., JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epidemiology & Health Economics, General Practice & Nursing Science, Onderzoek, Laan, W., Smeets, H, de Wit, N.J., Kahn, R.S., Grobbee, D.E., and Burger, H.

Published
2009

Catalog

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