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Purpose: The main advantages of charged particle radiotherapy compared to conventional X-ray external beam radiotherapy are a better tumor conformality coupled with the capability of treating deep-seated radio-resistant tumors. This work investigates the possibility to use oxygen beams for hadron therapy, as an alternative to carbon ions. Materials and Methods: Oxygen ions have the advantage of a higher relative biological effectiveness (RBE) and better conformality to the tumor target. This work describes the mixed radiation field produced by an oxygen beam in water and compares it to the one produced by a therapeutic carbon ion beam. The study has been performed using Geant4 simulations. The dose is calculated for incident carbon ions with energies of 162 MeV/u and 290 MeV/u, and oxygen ions with energies of 192 MeV/u and 245 MeV/u, and hence that the range of the primary oxygen ions projectiles in water was located at the same depth as the carbon ions. Results: The results show that the benefits of oxygen ions are more pronounced when using lower energies because of a slightly higher peak-to-entrance ratio, which allows either providing higher dose in tumor target or reducing it in the surrounding healthy tissues. It is observed that, per incident particle, oxygen ions deliver higher doses than carbon ions. Conclusions: This result coupled with the higher RBE shows that it may be possible to use a lower fluence of oxygen ions to achieve the same therapeutic dose in the patient as that obtained with carbon ion therapy. [ABSTRACT FROM AUTHOR]

Oxygen (O+) enhancements in the inner magnetosphere are often observed during geomagnetically active times, such as geomagnetic storms. In this study, we quantitatively examine the difference in ring current dynamics with and without a substantial O+ ion population based on almost 6 years of Van Allen Probes observations. Our results have not only confirmed previous finding of the role of O+ ions to the ring current but also found that abundant O+ ions are always present during large storms when sym‐H < −60 nT without exception, while having the pressure ratio (ℛ) between O+ and proton (H+) larger than 0.8 and occasionally even larger than 1 when L < 3. Simultaneously, the pressure anisotropy decreases with decreasing sym‐H and increasing L shell. The pressure anisotropy decrease during the storm main phase is likely related to the pitch angle isotropization processes. In addition, we find that ℛ increases during the storm main phase and then decreases during the storm recovery phase, suggesting faster buildup and decay of O+ pressure compared to H+ ions, which are probably associated with some species dependent source and/or energization as well as loss processes in the inner magnetosphere. Plain Language Summary: The behavior of the ionospheric O+ ions in the Earth's ring current should be carefully examined in order to advance our understanding of the role of ion composition in ring current dynamics. This problem has been extensively studied using past spacecraft missions. In this study, we revisit this problem based on almost 6 years of high‐quality data from the Van Allen Probes and have confirmed previous finding about the role of O+ ions to the ring current. For example, more O+ ions contribute to the ring current as sym‐H decreases, and O+ and total plasma pressures dramatically build up during storm time. Besides, our statistical results also provide evidence that without exception, ionospheric O+ ions make a significant contribution to the ring current during active time and their relative contribution to the ring current increases during the storm main phase and then decreases during the storm recovery phase compared to those of H+ ions, suggesting a faster buildup and decay of O+ pressure. In addition, the decrease of pressure anisotropy during the storm main phase is related to the pitch angle isotropization, which is probably caused by current sheet scattering or wave‐particle interaction. Key Points: We quantitatively examine how the total plasma pressure and pressure anisotropy changes with and without a substantial O+ ion populationO+ ions always make a nonnegligible contribution to the ring current when sym‐H < ‐60 nT with ℛ > 0.8The decrease of pressure anisotropy during storm main phase is related to pitch angle isotropization [ABSTRACT FROM AUTHOR]

The relationship between dispersive Alfvén waves (DAWs), magnetospheric activity, and O+ ion outflow/energy density is examined using measurements from the Van Allen Probes. We show that correlated DAW activity and O+ outflow/energization is a characteristic feature of the inner magnetosphere during active conditions and during storms persists for several hours over large L‐shell and azimuthal ranges of the plasma sheet. Though enhanced during substorm and storm active periods, these correlated features are most intense during geomagnetic storms. Comparisons show a linear relationship between DAW electric (and magnetic) field energy density and outflowing O+ energy. Statistical measurements from a large number of storms also reveal a linear relationship between DAW energy density and gross enhancements in energetic O+ energy densities. These observations support the notion that DAWs play an important role in the energization of O+ ions into and within the inner magnetosphere. Plain Language Summary: Geomagnetic storms are major disturbances in the Earth's magnetosphere, during which the particle content and pressure in the magnetosphere increase considerably. Much of the pressure increase is due to singly charged oxygen ions that come from the ionosphere. How this happens is not clear. Analyzing satellite observations, we found evidence suggesting that a particular type of low‐frequency electromagnetic wave called a dispersive Alfvén wave may be playing a key role. These waves are found to be more prevalent and intense in the magnetosphere during storms. Oxygen ion energies are shown to increase with increasing intensities of these waves. The oxygen ion contribution to pressure also increases in association with intensified wave activity. These observations support the notion that the waves energize and heat oxygen ions into and within the magnetosphere over extended periods of time, which leads to significant magnetospheric pressure increases. Key Points: Dispersive Alfven wave energy density is enhanced during substorms and geomagnetic stormsOxygen ion outflow energy and energy density are correlated with dispersive Alfven wave energy densityObservations support modeling that dispersive Alfven waves enhance oxygen ion energy density in the inner magnetosphere [ABSTRACT FROM AUTHOR]

Ion transport from the plasma sheet to the ring current is the main cause of the development of the ring current. Energetic (>150 keV) ring current ions are known to be transported diffusively in several days. A recent study suggested that energetic oxygen ions are transported closer to the Earth than protons due to the diffusive transport caused by a combination of the drift and drift‐bounce resonances with Pc 3–5 ultralow frequency waves during the 24 April 2013 magnetic storm. To understand the occurrence conditions of such selective oxygen increase (SOI), we investigate the phase space densities (PSDs) between protons and oxygen ions with the first adiabatic invariants (μ) of 0.1–2.0 keV/nT measured by the Radiation Belt Storm Probes Ion Composition Experiment instrument on the Van Allen Probes at L ~ 3–6 during 90 magnetic storms in 2013–2017. We identified the SOI events in which oxygen PSDs increase while proton PSDs do not increase during a period of ~9 hr (one orbital period). Among the 90 magnetic storms, 33% were accompanied by the SOI events. Global enhancements of Pc 4 and Pc 5 waves observed by ground magnetometers during the SOI events suggest that radial transport due to combination of the drift‐bounce resonance with Pc 4 oscillations and the drift resonance with Pc 5 oscillations can be the cause of SOIs. The contribution of the SOI events to the magnetic storm intensity is roughly estimated to be ~9% on average. Key Points: Increases of >150‐keV oxygen ions without proton increases are observed in the inner magnetosphere during 30 magnetic storms out of 90The selective oxygen increases occur simultaneously with global enhancements of Pc 4 and Pc 5 ULF waves at L > 4 and L > 3, respectivelyStatistical results suggest that the selective oxygen increases are caused by the combination of drift and drift‐bounce resonances [ABSTRACT FROM AUTHOR]

A dipolarization front (DF) is known as the leading edge of an earthward high‐speed flow with a sharp enhancement in the northward magnetic field (Bz). Analysis of an event observed by Cluster shows that the behavior of oxygen ions (O+) around the DF is very different from protons (H+). After the crossing of the DF, the O+ density decreases more gradually than H+. The distance between the density minimum of O+ and the DF layer is ~4 times longer than that of H+, which is close to their gyroradii ratio with the same energy. A flux dropout is observed in the O+ energy spectrum, whose energy dependence indicates that ions with higher energies can reach locations farther tailward of the DF. Similar variations are also seen in studies of 22 events in which a common pattern of ion properties is obtained by performing a superposed epoch analysis. Finally, using backward tracing test‐particle simulations, we reproduce the characteristics of the flux dropout and verify that the time dependence of the dropout is highly correlated with the gyromotion of different energy O+ behind the DF. All these results provide a further understanding of ion dynamics associated with DFs and suggest that the observed O+ ions are reflected within a half gyromotion in the central plasma sheet. Key Points: The reflection of oxygen ions at the dipolarization front is studied in both observations and simulationsA flux dropout could be observed in the O+ spectrum, whose contour is energy dependent and highly correlated with the gyromotion of different energy O+O+ can extend to a further position after the DF due to its larger gyro‐radius than that of H+ with the same energy [ABSTRACT FROM AUTHOR]

Enlargement of memory window through forming compliance current was demonstrated in Gd:SiO2 resistive random access memory (RRAM) with a gadolinium (Gd) electrode. Lower forming compliance current for Gd:SiO2 RRAM with a Gd electrode results in larger memory window as compared with the RRAM with a Pt electrode. Through analyses on the current conduction mechanism, we demonstrate that a lower forming compliance current leads to a thinner conductive filament forming and less oxygen ions penetrating into Gd electrode, which caused higher on current and lower off current. Furthermore, a possible resistive switching model was proposed to explain the effect of Gd electrode on RRAM device. [ABSTRACT FROM AUTHOR]