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The use of the term “fibroma” for any soft-tissue lesion or gingival lesion by general practitioners has led to inadequate diagnosis of quite a few rare entities. The occurrence of gingival lesions in adolescent female patients is a routine clinical finding. The site of occurrence of such a lesion is of prime significance, as the rarity of these lesions is determined by the site and size of the lesion. On the other hand, the dilemma over the diagnosis of peripheral ossifying fibroma (POF) versus peripheral odontogenic fibroma still continues. Commonly used synonyms for POF include calcifying fibroblastic granuloma, peripheral fibroma with calcification, peripheral cementifying fibroma, and calcifying or ossifying fibrous epulis. The present case report deals with the management of a unique case of POF between two maxillary central incisors in an adolescent female child patient, followed up to 2-year postsurgical excision.

Em cães, os neoplasmas na cavidade oral correspondem a cerca de 4 a 6% de todas os neoplasmas e destes, 65% são malignos. Este trabalho teve como objetivo realizar um estudo retrospectivo e reclassificação histológica dos casos de neoplasmas orais em cães diagnosticados no Setor de Patologia Veterinária (SPV) da Universidade Federal do Rio Grande do Sul (UFRGS), entre janeiro de 2004 a dezembro de 2016. Neste período, foram computados 14.222 casos de neoplasmas em cães, 735 eram da cavidade oral, dos quais 379 amostras foram incluídas neste estudo para a revisão histológica atualizada. Os cães SRD (sem raça definida) foram os mais frequentes, seguidos das raças Poodle, Cocker, Labrador e Boxer. A idade variou de um ano a 20 anos, com média de 9,85 anos e predomínio de cães machos. A localização principal foi a gengiva (55,67%), seguida de cavidade oral (região não especificada) (26,12%) e palato (5,8%). O melanoma foi a neoplasia mais frequente (31,93%), seguida pelo fibroma odontogênico periférico (24,01%), o ameloblastoma acantomatoso (15,57%) e o carcinoma de células escamosas. O presente estudo apresenta dados epidemiológicos e histológicos atuais a respeito dos neoplasmas orais em cães no Rio Grande do Sul. In dogs, neoplasms in the oral cavity correspond to about 4 to 6% of all neoplasms and of these, 65% are malignant. The objective of this study was to conduct a retrospective study and histological reclassification of cases of oral neoplasms in dogs diagnosed in the Setor de Patologia Veterinária (SPV) of the Universidade Federal do Rio Grande do Sul (UFRGS), between January 2004 and December 2016. In this period, 14,222 cases of neoplasms were counted in dogs, 735 were from the oral cavity, of which 379 samples were included in this study for the updated histological revision. Mixed-breed dogs were the most frequent, followed by Poodle, Cocker, Labrador and Boxer breeds. The age ranged from one year to 20 years, with a mean of 9.85 years and a predominance of male dogs. The main location was the gingiva (55,67%), followed by oral cavity (unspecified region) (26,12%) and palate (5,8%). Melanoma was the most frequent neoplasm (31.93%), followed by peripheral odontogenic fibroma (24.01%), acanthomatous ameloblastoma (15.57%) and squamous cell carcinoma. The present study supports and promotes current epidemiological and histological data regarding oral neoplasms in dogs in Rio Grande do Sul.

The purpose of the study is to document a rare case of a peripheral odontogenic fibroma with associated cervical and coronal tooth resorption in a 38 year old woman. Histopathological features are described, the clinical management outlined and follow-up observations over 27 years detailed. The exophytic firm lesion, coral pink in appearance, located on the labial aspect of a maxillary right lateral incisor was excised, fixed in formalin and prepared for histological evaluation. The resorption cavity and adjacent soft tissue were treated by the topical application of trichloroacetic acid prior to restoration with a glass-ionomer cement and subsequent root canal treatment. Histologically, the body of the lesion was characterized by the presence of odontogenic epithelium embedded in a mature fibrous stroma. Areas of dystrophic calcification could also be identified. The features were consistent with a diagnosis of a peripheral odontogenic fibroma. The clinical result of treatment assessed 27 years postoperatively showed no evidence of recurrence of the peripheral odontogenic fibroma. External cervical and coronal tooth resorption can, on rare occasions, prove to be a clinical feature associated with peripheral odontogenic fibroma. Treatment of the tumour mass and the resorptive lesion can provide a successful outcome.

El Fibroma Odontogénico Periférico fue definido por la OMS en el año 2005 como una neoplasia benigna rara constituida por tejido fibroso maduro y una cantidad variable de epitelio odontogénico inactivo. Dada su presentación clínica, localización y baja prevalencia suele ser mal diagnosticado como una lesión reaccional. Se presenta un caso clínico de fibroma odontogénico periférico tratado mediante remoción quirúrgica y se realiza una revisión de la bibliografía respecto a la patología con el propósito de esclarecer algunos aspectos de esta lesión, además de incluirla dentro de los posibles diagnósticos diferenciales de lesiones reaccionales gingivales. El objetivo del siguiente artículo es presentar un caso clínico de FOP tratado mediante remoción quirúrgica y aportar en el diagnóstico diferencial de las lesiones reaccionales gingivales. Peripheral odontogenic fibroma was described by the World Health Organization (WHO) in 2005, as a rare benign tumor containing mature fibrous connective tissue with a varying amount of inactive odontogenic epithelium. Though its clinical presentation, localization and low prevalence, it tends to be misdiagnosed as a reactive lesion. We present a case report of a Peripheral Odontogenic Fibroma treated by surgical resection and a narrative review of the literature with the purpose of clarifying different aspects of this lesion besides considering it as a possible differential diagnosis of reactive gingival lesions. The purpose of this article is to present a case report of peripheral odontogenic fibroma treated by surgical resection. Also to contribute to the differential diagnosis of gingival reactive lesions.

Peripheral odontogenic fibroma (POdF) is a rare benign odontogenic neoplasm. It represents the soft tissue counterpart of central odontogenic fibroma. The embryonic source of POdF has been suggested by many as arising from the rest of dental lamina that has persisted in the gingiva following its disintegration. It presents clinically as a firm, slow growing and sessile gingival mass, which is difficult to distinguish with more common inflammatory lesions. Very few cases of recurrence have been documented. It has been stated that histological budding of basal cell layer of the surface squamous epithelium is associated with higher recurrence and the presence of calcification in direct apposition to the epithelial rest is associated with lower recurrence. Hereby, we present a case which histologically exhibited budding of the basal cell layer, which could have been the reason for its recurrence.

Peripheral odontogenic fibroma (POF) is a rare odontogenic tumor. It commonly mimics other peripheral exophytic lesions like pyogenic granuloma, peripheral ossifying fibroma, and peripheral giant cell granuloma. It needs to be differentiated from other lesions by its different clinical behavior.

Historically, the classification of localized gingival fibrous lesions has been inconsistent, leading to multiple naming schemes and confusion among pathologists. Currently, lesions are broadly grouped into localized hyperplastic lesions and true neoplasms. Although some cases are clearly defined histologically (i.e., peripheral ossifying fibroma, peripheral odontogenic fibroma), another set of "reactive" fibrous lesions exhibit overlapping histologic features including nondistinctive fibrosis and inflammation. This group can exhibit recurrence, classically related to a local stimulus. However, when local factors are absent, recurrence suggests inherent neoplastic potential. Herein, we describe 2 recurrent fibrous gingival masses, one of which reportedly recurred 3 times with no obvious inciting agent. The histologic appearance of both lesions was similarly distinctive but not well classifiable, while the immunohistochemical profile indicated divergent lesions. This highlights the need for further study of recurrent gingival fibrous lesions to better predict independent growth potential.

Peripheral odontogenic fibroma is considered a gingival tumor characterized by a proliferation of relatively cellular fibrous or fibromyxomatous connective tissue which exhibits variable amounts of odontogenic epithelium and sometimes foci of calcification in the form of dentinoid, cementicles, or bone. It is considered the extraosseous counterpart of central odontogenic fibroma. This lesion usually is presented as a focal swelling in the gingiva, occurring in a wide age range, and the anterior region of the gingiva is the most frequent anatomic site. Conservative local excision is the treatment frequently adopted and its recurrence rate varies widely, and its biologic behavior is still unknown. In this study, the authors discuss 3 cases of peripheral odontogenic fibroma, and present their clinical and histopathological features and management.

PERIPHERAL ODONTOGENIC FIBROMA: AN UNUSUAL CASE ABSTRACT Peripheral odontogenic fibroma (POF) is a benign odontogenic neoplasm of fibroblastic origin characterized by relatively mature collagenous fibrous tissue and varying amounts of odontogenic epithelium. The lesions are treated by conservative surgical excision. However, it is considered to be with a potential to recur. This paper presents a peripheral odontogenic fibroma case report and emphasizes the accurate diagnosis and importance of patient follow-up. Keywords: Peripheral odontogenic fibroma, benign neoplazm, periodontal surgery PERIFERIAL ODONTOJENIK FIBROMA: NADIR BIR OLGU OZET Periferal odontojenik fibroma (POF) degisik miktarlarda odontojenik epitel ve kismen olgun kollojenoz fibroz doku icermesiyle karekterize fibroblastik orjinli benign odontojenik neoplazmdir. Lezyonlar konservatif cerrahi eksizyonla tedavi edilir. Bununla birlikte tekrar olusma potansiyeliyle dikkate alinir. Bu makale periferal odontojenik fibroma olgusu takdim etmekte ve dogru tani ve hasta takibinin onemini vurgulamaktadir. Anahtar Kelimeler: Periferial odontojenik fibroma, benign neoplazm, periodontal cerrahi

Peripheral ossifying fibroma (POF) occurs as a gingival overgrowth. The purpose of this article is to present a case of POF, briefly reviewing the current literature on this condition and emphasize the importance of inclusion of this lesion into list of all the pathologies, specially the gingival overgrowths. A case report of peripheral ossifying fibroma (POF) is reported in young adolescent which comprises the growth that occurred in the mandibular anterior region with displacement of anterior teeth, its satisfactory management and literature review. POF represents a reactive benign lesion of connective tissue and is not the soft tissue counterpart of ossifying fibroma and is also not related to peripheral odontogenic fibroma. Careful clinical examination and histopathology findings should be correlated to conclude the final diagnosis. Treatment consists of surgical excision with periodic follow-ups to observe any recurrence.

The differential diagnosis of exophytic gingival lesions include peripheral odontogenic fibroma, peripheral giant cell granuloma, pyogenic granuloma, and peripheral ossifying fibroma (POF). The peripheral odontogenic broma, the peripheral counterpart of the central dontogenic fibroma, is neoplastic, whereas the othrs are generally regarded reactive in nature. The roliferative activity of the reactive lesions are conidered to be initiated by local irritants occurring in he gingival crevice or associated with adjacent teeth. hese irritants stimulate the gingival fibers of the eriodontal ligament, a specialized periosteal tissue, r the periosteum itself. Depending on the tissue timulated, these fibrous growths may contain bone nd/or cementum. The POF has been described by many names, includng ossifying fibroid epulis, peripheral fibroma with alcification, calcifying fibroplastic granuloma, and eripheral odontogenic fibroma. Gardner convincingly argued that the term peripheral odontogenic fibroma be reserved for those lesions that are neoplastic and have characteristic odontogenic epithelium. This diagnosis would include only those lesions that meet the World Health Organization criteria. He also reinforced the concept that the POF is not the peripheral variant of the central ossifying fibroma, a true neoplasm, but a distinct non-neoplastic inflammatory proliferation. POF occurs more frequently in female than in male individuals, is more common in the maxilla, and generally presents as a painless mass smaller than 2 cm. Occasionally larger lesions have been reported in the literature. The generally ac

Central odontogenic fibroma has been defined as a benign odontogenic tumor, representing the intraosseous counterpart of a peripheral odontogenic fibroma. The odontogenic fibroma is a rare tumor. Differential diagnosis of radiolucent lesions in the molar-premolar region of mandible which involve impacted tooth may include central odontogenic fibroma, hyperplastic dental follicle, dentigerous cyst, unicystic ameloblastoma, and keratocystic odontogenic tumor. We describe an example of a small central odontogenic fibroma mimicking hyperplastic dental follicle and dentigerous cyst, resulting in uneruption of a primary tooth.

Objective—To characterize clinicopathologic features of the most common odontogenic tumors and focal fibrous hyperplasia (FFH) in dogs. Design—Retrospective case series. Animals—152 dogs evaluated for oral tumors of possible odontogenic origin at the William R. Pritchard Veterinary Medical Teaching Hospital of the University of California-Davis between 1995 and 2005. Procedures—Information was collected from records, including dog breed, age, reproductive status, and location of lesion in the oral cavity. Histologic slides pertaining to each dog were reviewed by 3 investigators. Data regarding clinicopathologic features of the 3 most common lesions (canine acanthomatous ameloblastoma [CAA], peripheral odontogenic fibroma [POF], and FFH) were summarized. Results—152 dogs with odontogenic tumors or FFH were identified. Sixty-eight (45%) dogs had CAA, 47 (31 %) had POF, 24 (16%) had FFH, and 13 (9%) had other odontogenic tumors. Canine acanthomatous ameloblastoma was present most commonly in the rostral aspect of the mandible, with POF and FFH more common in the rostral aspect of the maxilla. Males and females were equally represented among dogs with CAA and FFH. Castrated males were overrepresented among dogs with POF. Golden Retrievers, Akitas, Cocker Spaniels, and Shetland Sheepdogs were overrepresented among dogs with CAA. No breed predisposition was detected for FFH or POF. Dogs with FFH had a greater mean age at initial evaluation than did dogs with CAA or POF. Conclusions and Clinical Relevance—CAA, POF, and FFH have distinct clinical patterns that may help clinicians and pathologists identify such lesions more readily.

Background/Purpose Odontogenic fibroma (ODF) is a rare odontogenic tumor. It can be further divided into peripheral odontogenic fibroma (PODF) and central odontogenic fibroma (CODF). This retrospective study evaluated the clinical and histopathological features of 15 ODFs in Taiwanese patients. Methods Fifteen consecutive cases of ODF were collected from 1984 to 2009. The clinical data and microscopic features of these cases were reviewed and analyzed. Results Twelve PODFs were excised from six male and six female patients (mean age: 35 years) and three CODFs from two male and one female patients (mean age: 11 years). Eight of the 12 PODFs were found on the mandibular gingiva and four on the maxillary gingiva, with the most common site being the mandibular anterior and premolar region (5 cases). Two CODFs were located in the molar region of the mandible and one in the anterior maxilla. Two CODFs showed a mixed lesion and one a radiolucent lesion. No recurrence of the 15 ODFs was found after total excision or enucleation. Microscopically 58.3% of the PODFs showed surface ulceration. Calcified foci composed of osteoid, cementoid, or cementicle-like materials were noted in all 15 ODFs. Nests or strands of odontogenic epithelium were found in all 15 ODFs. The stromal component was mainly fibro-collagenous in nine of the 12 PODFs, whereas two of the three CODFs contained predominantly myxomatous stroma. Conclusion PODFs occurred more commonly than CODFs. PODF showed an equal sex distribution and was found more frequently in patients in the third to fourth decades of life. The most commonly affected site was the mandibular gingiva, especially the anterior and premolar gingiva. Only three CODFs were found; therefore, we could not draw any conclusions about CODF in Taiwanese patients.

Here, we present a case report of peripheral ossifying fibroma (POF) in an adult lady in her fourth decade of life. This case report comprises the growth that occurred in the mandibular anterior region with displacement of anterior teeth, its satisfactory management and literature review. POF represents a reactive benign lesion of connective tissue and is not the soft tissue counterpart of ossifying fibroma and is also not related anyhow to peripheral odontogenic fibroma. POF in the age of 45 years, arising in the mandibular anterior region, is an occasional entity. Careful clinical examination and histopathology findings should be correlated to conclude the final diagnosis.

Purpose The aim of this study was to assess the relative frequency of peripheral odontogenic fibroma (POdF) in an Iranian population and to compare the obtained data with previous reports. Materials and Methods Archival material was retrospectively analyzed from 1967 to 2007, and all microscopic slides of lesions considered in the differential diagnosis of POdF were retrieved. A diagnosis of POdF was made according to the criteria described by the World Health Organization in 2005. Demographic data, including age, gender, site of involvement, and previous history of POdF, were recorded for all samples with a diagnosis of this neoplasm. Results Nineteen POdFs were identified, which accounted for 0.14% of the archival cases. One of these tumors was a recurrence, diagnosed 12 months earlier. All cases were of the epithelium-rich or World Health Organization histologic subtype and most tumors occurred in the mandible. No significant difference in the prevalence of POdF was found between the studied variables. Among the 18 primary neoplasms, follow-up was possible for 2 to 13 years in 6 cases, and none developed recurrence. Conclusion Similar to previous investigations, this study shows that POdFs are uncommon odontogenic lesions. Detailed information on POdF is limited because of its rarity; therefore, this study may provide additional data for further investigations and may enable better understanding of this tumor.

) was evaluated because of right-sided facial swelling and a recent history of dysphagia and stridor. The squirrel was anesthetized to allow for phys-ical examination and collection of blood samples. Physical examination revealed a fracture of the maxillary right third premolar tooth and an associated abscess. Results of hematologic and serum biochemical testing were with-in reference limits for this species. While the squirrel was anesthetized, radiographs of the skull were obtained

The diagnostic process and interdisciplinary treatment of a healthy 12-year-old boy with impactions due to a localized peripheral odontogenic fibroma are presented. The treatment consisted of the surgical excision of the peripheral odontogenic fibroma and interceptive orthodontic treatment with an activator appliance to allow the passive eruption of the impacted teeth. Complete orthodontic treatment with fixed appliances was used later to level and coordinate the arches. This report illustrates the importance of early diagnosis and treatment of tooth impactions associated with diffuse gingival enlargement. The cooperation of various specialists in making a differential diagnosis, developing a comprehensive plan for conservative treatment, and delivering excellent care led to a successful result for this patient.

Excisional biopsies of gingival overgrowths, performed with safety margins, frequently result in mucogingival defects. These defects may produce esthetic problems and increase the chances of dentin hyperesthesia and its possibility of hindering oral hygiene.Two clinical cases are reported in which gingival overgrowths were removed by excisional biopsy, resulting in unsightly defects. The first clinical case presents an invasive approach for the treatment of a recurrent pyogenic granuloma in the anterior maxilla, and the second depicts a complete removal of a peripheral odontogenic fibroma in the posterior maxilla. In both situations, the soft-tissue defects were repaired by periodontal plastic surgery, including a laterally positioned flap and a coronally positioned flap, respectively.Periodontal plastic surgery successfully restored the defects that resulted from biopsies, and no recurrence has been noticed in the 5-year postoperative follow-up period.The combination of biopsy and periodontal plastic surgery in a one-step procedure seems to be suitable to remove gingival overgrowths in most areas of the mouth, regardless of esthetic significance. Such procedures seem to restore gingival health, encourage healing, and create both esthetics and function in the excised area.

Objective. This study sought to determine the relative frequency of odontogenic tumors in a Nigerian population and to compare these data with previous reports. Study design. Records of patients seen at the Lagos University Teaching Hospital between January 1980 and December 2003, with histologic diagnosis of odontogenic tumors (based on World Health Organisation classification, 1992), were analyzed. Results. Odontogenic tumors constituted 9.6% of all the biopsies of oral and jaw lesions seen within the period under study. Three hundred and eight (96.6%) were intraosseous, and 11 (3.4%) were peripheral (peripheral odontogenic fibroma = 7; peripheral myxoma = 3; peripheral ameloblastoma = 1). The mean age of patients was 29.9 6 15.6 years (range, 4-85 years). Among these cases, 96.6% of the tumors were benign and 3.4% were malignant. Ameloblastoma with predilection for the mandible was the most frequent odontogenic tumor (63%), followed by adenomatoid odontogenic tumor (AOT) (7.5%), myxoma (6.5%), calcifying epithelial odontogenic cyst (5.3%), and odontogenic fibroma (5.3%). More cases of malignant odontogenic tumors were seen than cases of calcifying epithelial odontogenic tumor and odontomas. The mean ages of patients with AOT, ameloblastic fibroma, and odontoma were significantly lower than those with ameloblastoma (P \ .05). No significant difference was found between the mean ages of patients with benign odontogenic tumors and those with malignant odontogenic tumors (P = .058). Conclusions. Odontogenic tumors, especially ameloblastoma, are not considered rare among Nigerians, whereas odontoma, regarded as the most frequent odontogenic tumor in North and South America, is rare. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99:191-5) Odontogenic tumors (OT) are a group of heterogenous lesions derived from epithelial and/or mesenchymal

A case of peripheral odontogenic fibroma occurring in the posterior region of the maxilla in a 7-year-old girl is presented. The patient was referred to our hospital because of a painless swelling in the buccal gingiva at 6 1. Physical examination revealed a localized elastic-hard tumor, with no radiological abnormalities in the adjacent alveolar bone. A biopsy specimen showed proliferation of fibroblastic cells in the submucosal layer. With the patient under general anesthesia, the tumor was resected subperiosteally, and the underlying bone surface was smoothened with a bur. Histologically, the lesion was composed of cellular fibrous connective tissue with scattered regions of cellular strands interwoven with less cellular areas and islands of odontogenic epithelium. The final diagnosis was peripheral odontogenic fibroma. Specific staining demonstrated that the tumor stroma contained large amounts of oxytalan fibers and tenascin. A positive reaction for tenascin was found to be a valuable pathohistological marker that could distinguish between peripheral odontogenic fibroma and calcifying fibrous epulis.As of about 9 years after the operation, there has been no evidence of recurrence.

Background Neoplastic lesions of the mammary gland, lymph nodes, or oral cavity in African pygmy hedgehogs (Atelerix albiventris) are common in captive animals. Chemotherapy and radiotherapy protocols have not yet been established for the African pygmy hedgehog. Thus, surgical resection is the current treatment of choice in this species. Case presentation A 5-year-old male African pygmy hedgehog showed multiple erythematous, round small tumors located in the oral cavity, on both sides of maxilla. The treatment of choice was surgical resection of tumors using a surgical knife under general anesthesia. Excised neoplastic lesions were diagnosed as peripheral odontogenic fibroma by histopathology. Six months after surgery relapse of tumors in the oral cavity was not observed. Conclusions The treatment adopted in this case report is safe for the patient and provides the best solution for mild proliferative lesions of the oral cavity. To our knowledge this is the first report of surgical resection of oral tumors (peripheral odontogenic fibroma) in the African pygmy hedgehog.

Analysis of case records of 46 patients with peripheral odontogenic fibroma (1967-95) diagnosed in the Division of Stomatology, Institute for Medical Research, Kuala Lumpur, disclosed a relatively young age of onset (mean, 32.2 years; range 5 months-64 years; peak incidence second decade of life), a slight female preponderance (M:F ratio 1:1.3), no racial predilection, a slight bias towards location in the mandible (52%) and a wide histomorphological range. All cases were treated by simple excision. Follow-up records were generally not available, so we do not know what the recurrence rate is.

This report describes the case of a 12-year-old girl who presented with diffuse enlargements of the anterior gingiva in both jaws. The clinical diagnosis was an inflammatory hyperplasia, but gingivectomy samples from all involved sites showed similar histological features consistent with odontogenic fibroma. Another peculiar finding was generalised mottled enamel. This is the fifth case of a diffuse clinical variant of peripheral odontogenic fibroma documented in the literature.

Objective: To perform a comparative study of the cellular proliferation in the peripheral and central fibromas. Material and Methods: Immunohistochemistry for PCNA and the AgNOR technique were performed in 9 cases of peripheral odontogenic fibroma (POF), in 4 cases of odontogenic fibroma (OdF), in 8 cases of peripheral ossifying fibroma (PEOF) and 7 cases of ossifying fibroma (OsF). The Kruskal-Wallis and Mann-Whitney tests were used for the statistical analyses. Results: Mesenchymal component of the central lesions presented a higher mean number of AgNOR per nucleus and PCNA index than did the peripheral lesions (P≤0.05). The mean number of AgNOR per nucleus in the epithelial component proved to be higher in the OdF than in the POF (P≤0.05). The mesenchymal and epithelial components presented similar mean numbers of AgNOR per nucleus and PCNA index in the OdF, as well as a similar mean number of AgNOR per nucleus in the POF. Conclusions: The mesenchymal component may well play a role in the differences between the biological behaviour of the central lesions as compared to the peripheral lesions. Moreover, considering that the epithelial and mesenchymal components in odontogenic fibromas presented a similar proliferation index, more research is warranted to understand the true role of the epithelial components, which are believed to be inactive in nature, as well as in the development and biological behaviour of these lesions.

This article is based on a review of the literature and the study of pathology sections obtained from various veterinary pathology laboratories. Epulis is a non-specific, clinical designation for a localized, exophytic growth on the gingiva. Four reactive epulides occur in human beings, namely focal fibrous hyperplasia (fibrous epulis), pyogenic granuloma, peripheral giant cell granuloma (giant cell epulis), and peripheral ossifying fibroma (calcifying fibrous epulis). The first three also occur in dogs but only focal fibrous hyperplasia appears to be common. The peripheral ossifying fibroma has not yet been reported in dogs. Odontogenic tumors occurring on the gingiva (i.e., as epulides) are referred to as peripheral odontogenic tumors. Three types have been reported in dogs. One, the common fibromatous epulis, is equivalent to the rare peripheral odontogenic fibroma in human beings. Another, the acanthomatous epulis, appears to be a form of ameloblastoma but differs from the peripheral ameloblastoma in human beings in that it invades bone; its biological behavior is therefore that of the human intraosseous ameloblastoma. The third, a rare lesion, has been referred to in the veterinary literature as a calcifying epithelial odontogenic tumor, although it is not the canine counterpart of the human CEOT. The term, amyloid-producing odontogenic tumor, has been suggested as being appropriate for this lesion.

Odontogenic tumours are considered to be relatively rare; however, several histologically distinct types have been identified in dogs. The more common canine odontogenic tumours are peripheral odontogenic fibroma and canine acanthomatous ameloblastoma. The expression of cytokeratins (CKs) has been established for the human dental germ and odontogenic tumours. The aim of the present study was to describe the immunohistochemical expression of a panel of CKs in the epithelium of the canine dental germ, normal gingiva and odontogenic tumours arising in this species. Samples from 20 odontogenic tumours, 12 tooth germs and three normal gingival tissues were obtained. Each sample was stained with haematoxylin and eosin and subjected to immunohistochemistry for CK expression. The typical expression pattern of CKs in the odontogenic epithelium and gingiva of dogs was CK14 and CK5/6. CKs 7, 8, 18 and 20 were generally absent from the canine dental germ, gingiva and odontogenic tumours. Dogs and man therefore exhibit similar CK expression in the odontogenic epithelium.

espanolEl fibroma periferico odontogenico es una lesion tumoral de la submucosa oral o del ligamento periodontal causado por irritacion cronica como traumatismos locales, cuerpos extranos y calculo o ciertos factores que transforman el tejido conectivo de las mucosas en tejido fibroso. Es de crecimiento lento, asintomatico y en ocasiones involuciona cuando se eliminan los factores causales. El tratamiento consta de escision quirurgica y curetaje de la base de la lesion para evitar recurrencias. Se presenta un caso clinico en el servicio de Estomatologia y cirugia oral de una Universidad en Cartagena Colombia, de un paciente de 36 anos de edad, masculino y sistemicamente sano con impresion clinica de fibroma periferico odontogenico ubicado en el tercio anterior derecho de paladar duro, ulcerado y asintomatico de un ano de evolucion. Se ejecutan diversos estudios paraclinicos como radiografias panoramicas, periapicales y oclusales para descartar afeccion a estructuras oseas. Previo a la firma de un consentimiento informado se realizo procedimiento quirurgico que consto de la escision quirurgica de la lesion para posterior analisis histopatologico que confirmo el diagnostico. EnglishThe peripheral odontogenic fibroma is a tumor of the oral submucosa, or periodontal ligament caused by chronic irritation, local trauma, dental calculus foreign agents or certain agents that may transform the connective tissue of the mucous membranes in fibrous tissue. It is like slow growing, asymptomatic and sometimes regress when the etiologic factors are eliminated. Treatment consists of surgical excision and curettage of the base of the lesion to prevent recurrence. In this paper is presented a clinical case in the service of oral surgery and stomatology of a University in Cartagena Colombia, in a 36 years old patient, male and systemically healthy with clinical impression of peripheral odontogenic fibroma located in the anterior third of right palate hard, ulcers and asymptomatic one years of evolution. It was tested different studies, such as panoramic radiographs, periapical and occlusal, for discard condition involving hard tissues. Before signing an informed consent was performed surgical procedure that consisted of surgical excision of the lesion for subsequent histopathological analysis that confirmed the diagnosis.

Objective The peripheral odontogenic fibroma (POdF) is a rare benign neoplasm of odontogenic origin with limited data on recurrence. The purpose of this study was to define the clinical and histopathologic spectrum of POdF and to investigate its recurrence rate and variables associated with its recurrence. Study design A total of 151 cases of POdF were accepted for this study, which documented clinical, histopathologic, and follow-up data. Multivariate stepwise logistic regression was used to investigate the association of categorical variables and recurrence. Results POdF should be considered a mixed odontogenic tumor because it is composed of active odontogenic epithelial and ectomesenchymal components. Of the 58 cases with follow-up, 29 recurred. Budding of the basal cell layer of the surface squamous epithelium was associated with higher recurrence (P = .0186); 27 cases with recurrence which exhibited this feature. The presence of calcification in direct apposition to epithelial rests was associated with lower recurrence (P = .0076); 13 cases that did not recur exhibited this feature. Conclusions POdF has a 50% recurrence rate. Budding of the surface epithelium and calcification in apposition to odontogenic epithelial rests are histologic predictors of recurrence.

normal;" Se presentan dos casos clínicos de fibroma odontogénico periférico (FOP) entidad poco frecuente. Fueron diagnosticados, tratados y seguidos en las Cátedras de Patología, Semiología y Clínica Estomatológica y de Anatomía Patológica Buco-máxilo-facial de la Facultad de Odontología (UDELAR). La baja frecuencia de esta lesión en la literatura y el diagnóstico diferencial que plantea con otras lesiones hace interesante su publicación. Ambos afectaron a mujeres de 6 y 57 años respectivamente Two case reports of peripheral odontogenic fibroma (POF), a rare clinical lesion, are presented. They were diagnosed, treated and followed at the Departments of Pathology, Semiology and Stomatology Clinic and Pathologic Anatomy Laboratory of Dental Public School, University of Uruguay (UDELAR). Few cases are reported in the literature; the possible differential diagnosis with other clinical entities make it interesting to publish. Both occured in 6 and 57-year-old females respectively

Informes de casos Acompañan al trabajo 9 figuras Se presentan dos casos de fibroma odontogénico periférico (FOP) entidad poco frecuente. Fueron diagnosticados, tratados y seguidos en las Cátedras de Patología, Semiología y Clínica Estomatológica y de Anatomía Patológica Buco Maxilo-facial de la Facultad de Odontología (UdelaR). La baja frecuencia de esta lesión en la literatura y el diagnóstico diferencial que plantea con otras lesiones hace interesante su publicación. Ambos afectaron a mujeres de 6 y 57 años respectivamente. (AU)

This article compares the clinical and histopathologic features of the peripheral odontogenic fibroma in human beings and the fibromatous epulis in dogs. They are apparently equivalent lesions. Both are odontogenic tumors of limited growth potential that do not recur if adequately excised; both occur in middle and late adulthood of the species concerned. The one difference is that the peripheral odontogenic fibroma is a rare condition, whereas the canine fibromatous epulis is common.

Odontogenic fibroma is a benign odontogenic tumor that may arise centrally in the jawbones or peripherally on the gingiva. Odontogenic fibroma has three rare variants, that is, odontogenic fibroma with giant cell lesion, odontogenic fibroma with ossifications and odontogenic fibroma with amyloid-like protein deposition. It occurs most often in females, usually located in the anterior aspect of the maxilla, presenting as a well-circumscribed radiolucency that may induce root resorption. Here, we present a case of ossifying variant of peripheral odontogenic fibroma with its clinical presentation, radiological and histological features along with the satisfactory management and literature review.

Summary. Aim. The present paper reports a case of peripheral odontogenic fibroma (POF) (WHO type) in a newborn. The differential diagnosis and treatment were discussed. Background. POF is well described in the literature, but this is the first report in a newborn. Patient. A 4-month-old female newborn was referred to our department because of an exophytic, sessile, firm, and well-delimited lesion on the right upper alveolar ridge. The covering mucosa was apparently normal. The lesion measuring 10 × 3 mm was present since birth. The clinical diagnosis of congenital granular cell tumour (congenital epulis) or dental lamina cyst of the newborn was made. A conservative excisional biopsy was performed under local anaesthesia, and the specimen was submitted to histopathological examination. Results. The microscopic examination revealed a pattern of POF (WHO type). Normal primary incisors teeth eruption, and no signs of recurrence were noted on 16 months follow-up. Conclusion. Despite the rarity of POF in a newborn, this lesion should be included as a possible diagnosis to focal gingival growth.

Peripheral odontogenic fibroma is a rare lesion that arises on the gingiva and can clinically mimic a variety of reactive lesions, benign neoplasms, and metastases. We describe a symptomatic lesion arising on the mandibular gingiva of a 58-year-old female with no history of trauma or dental disease in the area. An excisional biopsy showed the lesional stroma to contain numerous polyhedral granular cells with occasional interspersed islands of inactive odontogenic epithelium. We believe this to represent the fourth case of peripheral granular cell odontogenic fibroma to be reported in detail in the literature.

Background: Peripheral (extraosseous) odontogenic tumors are rare, and reports in the literature have mainly been single case reports or a small series of cases. The aim of this study was to determine the relative frequency of peripheral (extraosseous) odontogenic tumors relative to one another and relative to their central (intraosseous) counterparts in an oral pathology biopsy service and to compare these data with information available in the literature. Methods: The files of the Pacific Oral and Maxillofacial Pathology Laboratory of the University of the Pacific, San Francisco, CA, USA, served as the source of material for this study. Files were systematically searched for all cases of peripheral odontogenic tumors (POTs) during a 20-year-period. Results: There were 91 178 cases accessed in which central and POTs were identified in 1133 (1.24%), central tumors in 1088 (1.2%), and peripheral tumors in 45 (0.05%). Peripheral tumors accounted for 4% of all 1133 central and POTs. Peripheral odontogenic fibroma (PODF) was the most common of the 45 POTs accounting for 51.1% (23 cases) followed by peripheral ameloblastoma (PA) 28.9% (13 cases) and peripheral calcifying cystic odontogenic tumor (PCCOT) 13.3% (six cases). Peripheral calcifying epithelial odontogenic tumor, peripheral ameloblastic fibroma, and peripheral ameloblastic carcinoma were also identified – each comprised 2.2% (one case each). PODF was more common than its central counterpart by a 1.4:1 ratio. This was the only peripheral tumor that was more common than its central counterpart. PA accounted for 9.3% of all ameloblastomas and PCCOT for 26% of all calcifying cystic odontogenic tumors. Conclusion: There is only scarce information in the literature on the relative frequency of POTs. Additional studies should be conducted to determine the true relative frequency. To ensure accuracy, pathologists with experience in the field of odontogenic tumors should conduct these studies. Intraosseous tumors that perforate through the bone to the gingival tissue, clinically presenting as ‘peripheral tumors’ should be excluded.