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52. Context v. algorithm: evidence that a transdiagnostic framework of contextual clinical characterization is of more clinical value than categorical diagnosis

Author

van Os, Jim, primary, Pries, Lotta-Katrin, additional, ten Have, Margreet, additional, de Graaf, Ron, additional, van Dorsselaer, Saskia, additional, Bak, Maarten, additional, Kenis, Gunter, additional, Lin, Bochao D., additional, Gunther, Nicole, additional, Luykx, Jurjen J., additional, Rutten, Bart P. F., additional, and Guloksuz, Sinan, additional

Published
2021
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53. Duration of anxiety disorder and its associated risk indicators:Results of a longitudinal study of the general population

Author

ten Have, Margreet, Tuithof, Marlous, van Dorsselaer, Saskia, Kleinjan, Marloes, Penninx, Brenda W.J.H., Batelaan, Neeltje M., de Graaf, Ron, Leerstoel Finkenauer, Youth in Changing Cultural Contexts, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Digital Health, Leerstoel Finkenauer, and Youth in Changing Cultural Contexts

Subjects
Adult, medicine.medical_specialty, Longitudinal study, Pediatrics, Population, population surveys, new episode, Comorbidity, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, medicine, Humans, anxiety disorder, risk factors, Longitudinal Studies, education, Aged, Netherlands, education.field_of_study, business.industry, Incidence (epidemiology), medicine.disease, Neuroticism, Anxiety Disorders, 030227 psychiatry, Diagnostic and Statistical Manual of Mental Disorders, Psychiatry and Mental health, Clinical Psychology, Anxiety, medicine.symptom, business, 030217 neurology & neurosurgery, Anxiety disorder, Cohort study
Abstract

Background: Data on episode duration of anxiety disorders are required for informing patients and for disease management, but such data from population studies are lacking. Methods: Three-year longitudinal data were used from the Netherlands Mental Health Survey and Incidence Study-2, a psychiatric epidemiological cohort study among the general adult population (N = 6646). Respondents with a new (first or recurrent) anxiety disorder were selected (n = 158). DSM-IV diagnoses were assessed with the Composite International Diagnostic Interview; the Life Chart Interview assessed episode duration and recovery rates. Results: Among those with anxiety disorder, median episode duration was 7.5 months and mean duration was 15.2 months. 38.8% had not recovered at 12 months and 30.1% not at 36 months. Longer duration was associated with older age, not having a paid job, higher neuroticism, more physical disorders, and worse physical functioning. Conclusions: Also, in the general population, anxiety disorder has a rather chronic course. After 12 months the cumulative recovery rate flattened. To prevent and manage chronicity, timely treatment, and chronic disease management are required. The risk indicators found may help to identify individuals with an anxiety disorder at risk for chronicity.

Published
2021
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54. Duration of anxiety disorder and its associated risk indicators: Results of a longitudinal study of the general population

Author

ten Have, Margreet, Tuithof, Marlous, van Dorsselaer, Saskia, Kleinjan, Marloes, Penninx, Brenda W.J.H., Batelaan, Neeltje M., de Graaf, Ron, ten Have, Margreet, Tuithof, Marlous, van Dorsselaer, Saskia, Kleinjan, Marloes, Penninx, Brenda W.J.H., Batelaan, Neeltje M., and de Graaf, Ron

Abstract

Background: Data on episode duration of anxiety disorders are required for informing patients and for disease management, but such data from population studies are lacking. Methods: Three-year longitudinal data were used from the Netherlands Mental Health Survey and Incidence Study-2, a psychiatric epidemiological cohort study among the general adult population (N = 6646). Respondents with a new (first or recurrent) anxiety disorder were selected (n = 158). DSM-IV diagnoses were assessed with the Composite International Diagnostic Interview; the Life Chart Interview assessed episode duration and recovery rates. Results: Among those with anxiety disorder, median episode duration was 7.5 months and mean duration was 15.2 months. 38.8% had not recovered at 12 months and 30.1% not at 36 months. Longer duration was associated with older age, not having a paid job, higher neuroticism, more physical disorders, and worse physical functioning. Conclusions: Also, in the general population, anxiety disorder has a rather chronic course. After 12 months the cumulative recovery rate flattened. To prevent and manage chronicity, timely treatment, and chronic disease management are required. The risk indicators found may help to identify individuals with an anxiety disorder at risk for chronicity.

Published
2021

55. Longitudinal bidirectional associations between internalizing mental disorders and cardiometabolic disorders in the general adult population

Author

Leerstoel Finkenauer, Youth in Changing Cultural Contexts, Nuyen, Jasper, Bos, Elisabeth H., de Jonge, Peter, van Dorsselaer, Saskia, Tuithof, Marlous, Kleinjan, Marloes, de Graaf, Ron, ten Have, Margreet, Leerstoel Finkenauer, Youth in Changing Cultural Contexts, Nuyen, Jasper, Bos, Elisabeth H., de Jonge, Peter, van Dorsselaer, Saskia, Tuithof, Marlous, Kleinjan, Marloes, de Graaf, Ron, and ten Have, Margreet

Published
2021

56. Duration of anxiety disorder and its associated risk indicators: Results of a longitudinal study of the general population

Author

Leerstoel Finkenauer, Youth in Changing Cultural Contexts, ten Have, Margreet, Tuithof, Marlous, van Dorsselaer, Saskia, Kleinjan, Marloes, Penninx, Brenda W.J.H., Batelaan, Neeltje M., de Graaf, Ron, Leerstoel Finkenauer, Youth in Changing Cultural Contexts, ten Have, Margreet, Tuithof, Marlous, van Dorsselaer, Saskia, Kleinjan, Marloes, Penninx, Brenda W.J.H., Batelaan, Neeltje M., and de Graaf, Ron

Published
2021

57. What makes the psychosis 'clinical high risk' state risky: psychosis itself or the co-presence of a non-psychotic disorder?

Author

Hersenen-Medisch 1, Brain, Hasmi, Laila, Pries, Lotta-Katrin, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Bak, Maarten, Kenis, Gunter, Richards, Alexander, Lin, Bochao D, O'Donovan, Michael C, Luykx, Jurjen J, Rutten, Bart P F, Guloksuz, Sinan, van Os, Jim, Hersenen-Medisch 1, Brain, Hasmi, Laila, Pries, Lotta-Katrin, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Bak, Maarten, Kenis, Gunter, Richards, Alexander, Lin, Bochao D, O'Donovan, Michael C, Luykx, Jurjen J, Rutten, Bart P F, Guloksuz, Sinan, and van Os, Jim

Published
2021

58. Schizophrenia and the Environment: Within-Person Analyses May be Required to Yield Evidence of Unconfounded and Causal Association-The Example of Cannabis and Psychosis

Author

Hersenen-Medisch 1, Brain, van Os, Jim, Pries, Lotta-Katrin, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Bak, Maarten, Wittchen, Hans-Ulrich, Rutten, Bart P F, Guloksuz, Sinan, Hersenen-Medisch 1, Brain, van Os, Jim, Pries, Lotta-Katrin, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Bak, Maarten, Wittchen, Hans-Ulrich, Rutten, Bart P F, and Guloksuz, Sinan

Published
2021

59. Predictive Performance of Exposome Score for Schizophrenia in the General Population

Author

Hersenen-Medisch 1, Brain, Pries, Lotta-Katrin, Erzin, Gamze, van Os, Jim, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Bak, Maarten, Rutten, Bart P F, Guloksuz, Sinan, Hersenen-Medisch 1, Brain, Pries, Lotta-Katrin, Erzin, Gamze, van Os, Jim, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Bak, Maarten, Rutten, Bart P F, and Guloksuz, Sinan

Published
2021

60. Evidence for an interrelated cluster of Hallucinatory experiences in the general population: an incidence study

Author

Hersenen-Medisch 1, Brain, Moriyama, Tais S, Drukker, Marjan, Guloksuz, Sinan, Ten Have, Magreet, de Graaf, Ron, van Dorsselaer, Saskia, Gunther, Nicole, Bak, Maarten, van Os, Jim, Hersenen-Medisch 1, Brain, Moriyama, Tais S, Drukker, Marjan, Guloksuz, Sinan, Ten Have, Magreet, de Graaf, Ron, van Dorsselaer, Saskia, Gunther, Nicole, Bak, Maarten, and van Os, Jim

Published
2021

61. The jumping to conclusions reasoning bias as a cognitive factor contributing to psychosis progression and persistence: findings from NEMESIS-2

Author

Hersenen-Medisch 1, Brain, Rauschenberg, Christian, Reininghaus, Ulrich, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Simons, Claudia J P, Gunther, Nicole, Henquet, Cécile, Pries, Lotta-Katrin, Guloksuz, Sinan, Bak, Maarten, van Os, Jim, Hersenen-Medisch 1, Brain, Rauschenberg, Christian, Reininghaus, Ulrich, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Simons, Claudia J P, Gunther, Nicole, Henquet, Cécile, Pries, Lotta-Katrin, Guloksuz, Sinan, Bak, Maarten, and van Os, Jim

Published
2021

68. Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway.

Author

van Os, Jim, Pries, Lotta-Katrin, ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Delespaul, Philippe, Bak, Maarten, Kenis, Gunter, Lin, Bochao D., Luykx, Jurjen J., Richards, Alexander L., Akdede, Berna, Binbay, Tolga, Altınyazar, Vesile, Yalınçetin, Berna, Gümüş-Akay, Güvem, Cihan, Burçin, Soygür, Haldun, Ulaş, Halis, and Cankurtaran, Eylem Şahin

Subjects
SCHIZOPHRENIA risk factors, HALLUCINATIONS, ADVERSE childhood experiences, GENETICS, CHRONOBIOLOGY disorders, PSYCHOSES, INTERVIEWING, MOLECULAR biology, CELLULAR signal transduction, REPLICATION (Experimental design), DESCRIPTIVE statistics, AFFECTIVE disorders, MENTAL depression
Abstract

Background: There is evidence that environmental and genetic risk factors for schizophrenia spectrum disorders are transdiagnostic and mediated in part through a generic pathway of affective dysregulation. Methods: We analysed to what degree the impact of schizophrenia polygenic risk (PRS-SZ) and childhood adversity (CA) on psychosis outcomes was contingent on co-presence of affective dysregulation, defined as significant depressive symptoms, in (i) NEMESIS-2 (n = 6646), a representative general population sample, interviewed four times over nine years and (ii) EUGEI (n = 4068) a sample of patients with schizophrenia spectrum disorder, the siblings of these patients and controls. Results: The impact of PRS-SZ on psychosis showed significant dependence on co-presence of affective dysregulation in NEMESIS-2 [relative excess risk due to interaction (RERI): 1.01, p = 0.037] and in EUGEI (RERI = 3.39, p = 0.048). This was particularly evident for delusional ideation (NEMESIS-2: RERI = 1.74, p = 0.003; EUGEI: RERI = 4.16, p = 0.019) and not for hallucinatory experiences (NEMESIS-2: RERI = 0.65, p = 0.284; EUGEI: −0.37, p = 0.547). A similar and stronger pattern of results was evident for CA (RERI delusions and hallucinations: NEMESIS-2: 3.02, p < 0.001; EUGEI: 6.44, p < 0.001; RERI delusional ideation: NEMESIS-2: 3.79, p < 0.001; EUGEI: 5.43, p = 0.001; RERI hallucinatory experiences: NEMESIS-2: 2.46, p < 0.001; EUGEI: 0.54, p = 0.465). Conclusions: The results, and internal replication, suggest that the effects of known genetic and non-genetic risk factors for psychosis are mediated in part through an affective pathway, from which early states of delusional meaning may arise. [ABSTRACT FROM AUTHOR]

Published
2022
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70. Longitudinal bidirectional associations between internalizing mental disorders and cardiometabolic disorders in the general adult population

Author

Nuyen, Jasper, Bos, Elisabeth H., de Jonge, Peter, van Dorsselaer, Saskia, Tuithof, Marlous, Kleinjan, Marloes, de Graaf, Ron, ten Have, Margreet, Leerstoel Finkenauer, Youth in Changing Cultural Contexts, Leerstoel Finkenauer, Youth in Changing Cultural Contexts, and Developmental Psychology

Subjects
Adult, medicine.medical_specialty, Health (social science), Social Psychology, Epidemiology, Population, Adult general population, Health(social science), 03 medical and health sciences, 0302 clinical medicine, RISK-FACTOR, Internal medicine, medicine, Cardiometabolic disorders, SYSTEMATIC ANALYSIS, Internalizing mental disorders, Humans, 030212 general & internal medicine, Prospective Studies, Risk factor, education, Prospective cohort study, Netherlands, education.field_of_study, business.industry, Mood Disorders, Incidence (epidemiology), Incidence, Mental Disorders, DIABETES-MELLITUS, HEALTH SURVEY, GLOBAL BURDEN, medicine.disease, Anxiety Disorders, 030227 psychiatry, Psychiatry and Mental health, Mood, MYOCARDIAL-INFARCTION, PROGNOSTIC ASSOCIATION, CARDIOVASCULAR-DISEASE, Cardiovascular Diseases, Cohort, POOR GLYCEMIC CONTROL, business, Anxiety disorder
Abstract

Purpose This prospective population-based study investigated whether having any internalizing mental disorder (INT) was associated with the presence and onset of any cardiometabolic disorder (CM) at 3-year follow-up; and vice versa. Furthermore, we examined whether observed associations differed when using longer time intervals of respectively 6 and 9 years. Methods Data were used from the four waves (baseline and 3-, 6- and 9-year follow-up) of the Netherlands Mental Health Survey and Incidence Study-2, a prospective study of a representative cohort of adults. At each wave, the presence and first onset of INT (i.e. any mood or anxiety disorder) were assessed with the Composite International Diagnostic Interview 3.0; the presence and onset of CM (i.e. hypertension, diabetes, heart disease, and stroke) were based on self-report. Multilevel logistic autoregressive models were controlled for previous-wave INT and CM, respectively, and sociodemographic, clinical, and lifestyle covariates. Results Having any INT predicted both the presence (OR 1.28, p = 0.029) and the onset (OR 1.46, p = 0.003) of any CM at the next wave (3-year intervals). Having any CM was not significantly related to the presence of any INT at 3-year follow-up, while its association with the first onset of any INT reached borderline significance (OR 1.64, p = 0.06), but only when examining 6-year intervals. Conclusions Our findings indicate that INTs increase the risk of both the presence and the onset of CMs in the short term, while CMs may increase the likelihood of the first onset of INTs in the longer term. Further research is needed to better understand the mechanisms underlying the observed associations.

Published
2020

72. The bidirectional relationship between loneliness and common mental disorders in adults: findings from a longitudinal population-based cohort study

Author

Leerstoel Finkenauer, Youth in Changing Cultural Contexts, Nuyen, Jasper, Tuithof, Marlous, de Graaf, Ron, van Dorsselaer, Saskia, Kleinjan, Marloes, Have, Margreet Ten, Leerstoel Finkenauer, Youth in Changing Cultural Contexts, Nuyen, Jasper, Tuithof, Marlous, de Graaf, Ron, van Dorsselaer, Saskia, Kleinjan, Marloes, and Have, Margreet Ten

Published
2020

73. Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health?

Author

TN groep Adan, Hersenen-Medisch 1, Brain, Marsman, Anne, Pries, Lotta-Katrin, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Bak, Maarten, Kenis, Gunter, Lin, Bochao D, Luykx, Jurjen J, Rutten, Bart P F, Guloksuz, Sinan, van Os, Jim, TN groep Adan, Hersenen-Medisch 1, Brain, Marsman, Anne, Pries, Lotta-Katrin, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Bak, Maarten, Kenis, Gunter, Lin, Bochao D, Luykx, Jurjen J, Rutten, Bart P F, Guloksuz, Sinan, and van Os, Jim

Published
2020

74. Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia

Author

Hersenen-Medisch 1, Brain, TN groep Adan, Neurogenetica, Pries, Lotta-Katrin, van Os, Jim, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Bak, Maarten, Lin, Bochao D, van Eijk, Kristel R, Kenis, Gunter, Richards, Alexander, O'Donovan, Michael C, Luykx, Jurjen J, Rutten, Bart P F, Guloksuz, Sinan, Hersenen-Medisch 1, Brain, TN groep Adan, Neurogenetica, Pries, Lotta-Katrin, van Os, Jim, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Bak, Maarten, Lin, Bochao D, van Eijk, Kristel R, Kenis, Gunter, Richards, Alexander, O'Donovan, Michael C, Luykx, Jurjen J, Rutten, Bart P F, and Guloksuz, Sinan

Published
2020

75. Association of preceding psychosis risk states and non-psychotic mental disorders with incidence of clinical psychosis in the general population: a prospective study in the NEMESIS-2 cohort

Author

Neurogenetica, Brain, Hersenen-Medisch 1, Guloksuz, Sinan, Pries, Lotta Katrin, ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Klingenberg, Boris, Bak, Maarten, Lin, Bochao D, van Eijk, Kristel R., Delespaul, Philippe, van Amelsvoort, Therese, Luykx, Jurjen J., Rutten, Bart P.F., van Os, Jim, Neurogenetica, Brain, Hersenen-Medisch 1, Guloksuz, Sinan, Pries, Lotta Katrin, ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Klingenberg, Boris, Bak, Maarten, Lin, Bochao D, van Eijk, Kristel R., Delespaul, Philippe, van Amelsvoort, Therese, Luykx, Jurjen J., Rutten, Bart P.F., and van Os, Jim

Published
2020

78. What makes the psychosis ‘clinical high risk’ state risky: psychosis itself or the co-presence of a non-psychotic disorder?

Author

Hasmi, Laila, primary, Pries, Lotta-Katrin, additional, ten Have, Margreet, additional, de Graaf, Ron, additional, van Dorsselaer, Saskia, additional, Bak, Maarten, additional, Kenis, Gunter, additional, Richards, Alexander, additional, Lin, Bochao D., additional, O'Donovan, Michael C., additional, Luykx, Jurjen J., additional, Rutten, Bart P.F., additional, Guloksuz, Sinan, additional, and van Os, Jim, additional

Published
2021
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80. Alcohol use and mental health in adolescents: interactions with age and gender--findings from the Dutch 2001 Health Behaviour in School-Aged Children survey *

Author

Verdurmen, Jacqueline, Monshouwer, Karin, Van Dorsselaer, Saskia, Bogt, Tom Ter, and Vollebergh, Wilma

Subjects
Mental health -- Research -- Comparative analysis, Alcohol and youth -- Research -- Influence -- Comparative analysis, Adolescent psychology -- Research -- Comparative analysis, Health, Psychology and mental health, Influence, Research, Comparative analysis
Abstract

ABSTRACT. Objective: This study examines the association between alcohol use and mental health in adolescence, specifically the interaction with age and gender. Method: Data were derived from the 2001 Health [...]

Published
2005

84. Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia

Author

Pries, Lotta-Katrin, primary, van Os, Jim, additional, ten Have, Margreet, additional, de Graaf, Ron, additional, van Dorsselaer, Saskia, additional, Bak, Maarten, additional, Lin, Bochao D., additional, van Eijk, Kristel R., additional, Kenis, Gunter, additional, Richards, Alexander, additional, O’Donovan, Michael C., additional, Luykx, Jurjen J., additional, Rutten, Bart P. F., additional, and Guloksuz, Sinan, additional

Published
2020
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86. Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway

Author

van Os, Jim, primary, Pries, Lotta-Katrin, additional, ten Have, Margreet, additional, de Graaf, Ron, additional, van Dorsselaer, Saskia, additional, Delespaul, Philippe, additional, Bak, Maarten, additional, Kenis, Gunter, additional, Lin, Bochao D., additional, Luykx, Jurjen J., additional, Richards, Alexander L., additional, Akdede, Berna, additional, Binbay, Tolga, additional, Altınyazar, Vesile, additional, Yalınçetin, Berna, additional, Gümüş-Akay, Güvem, additional, Cihan, Burçin, additional, Soygür, Haldun, additional, Ulaş, Halis, additional, Cankurtaran, Eylem Şahin, additional, Kaymak, Semra Ulusoy, additional, Mihaljevic, Marina M., additional, Petrovic, Sanja Andric, additional, Mirjanic, Tijana, additional, Bernardo, Miguel, additional, Mezquida, Gisela, additional, Amoretti, Silvia, additional, Bobes, Julio, additional, Saiz, Pilar A., additional, García-Portilla, María Paz, additional, Sanjuan, Julio, additional, Aguilar, Eduardo J., additional, Santos, José Luis, additional, Jiménez-López, Estela, additional, Arrojo, Manuel, additional, Carracedo, Angel, additional, López, Gonzalo, additional, González-Peñas, Javier, additional, Parellada, Mara, additional, Maric, Nadja P., additional, Atbaşoğlu, Cem, additional, Ucok, Alp, additional, Alptekin, Köksal, additional, Saka, Meram Can, additional, Arango, Celso, additional, O'Donovan, Michael, additional, Rutten, Bart P. F., additional, and Guloksuz, Sinan, additional

Published
2020
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87. Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health?

Author

Marsman, Anne, primary, Pries, Lotta-Katrin, additional, ten Have, Margreet, additional, de Graaf, Ron, additional, van Dorsselaer, Saskia, additional, Bak, Maarten, additional, Kenis, Gunter, additional, Lin, Bochao D, additional, Luykx, Jurjen J, additional, Rutten, Bart P F, additional, Guloksuz, Sinan, additional, and van Os, Jim, additional

Published
2020
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89. M126. THE MAIN AND INTERACTIVE EFFECTS OF ADULT STRESSFUL LIFE EVENTS WITH GENOMIC AND EXPOSOMIC LIABILITY FOR SCHIZOPHRENIA ON MENTAL AND PHYSICAL HEALTH: A PROSPECTIVE COHORT STUDY

Author

Pries, Lotta-Katrin, primary, ten Have, Margreet, primary, de Graaf, Ron, primary, van Dorsselaer, Saskia, primary, Gunther, Nicole, primary, Bak, Maarten, primary, Li, Bochao D, primary, Luykx, Jurjen J, primary, Rutten, Bart P F, primary, van Os, Jim, primary, and Guloksuz, Sinan, primary

Published
2020
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90. The jumping to conclusions reasoning bias as a cognitive factor contributing to psychosis progression and persistence: findings from NEMESIS-2

Author

Rauschenberg, Christian, primary, Reininghaus, Ulrich, additional, ten Have, Margreet, additional, de Graaf, Ron, additional, van Dorsselaer, Saskia, additional, Simons, Claudia J. P., additional, Gunther, Nicole, additional, Henquet, Cécile, additional, Pries, Lotta-Katrin, additional, Guloksuz, Sinan, additional, Bak, Maarten, additional, and van Os, Jim, additional

Published
2020
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92. Terugval en chroniciteit van depressieve stoornis in de algemene bevolking; resultaten van NEMESIS-2

Author

ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia A F M, Tuithof, Marlous, Kleinjan, M., Penninx, Brenda W J H, Leerstoel Finkenauer, and Youth in Changing Cultural Contexts

Subjects
uitkomst, chroniciteit, risico-indicatoren, bevolkingsonderzoek, depressieve stoornis, terugval
Abstract

ACHTERGROND Het natuurlijke beloop van depressieve stoornis (mdd) en risico-indicatoren van terugval en chroniciteit van mdd kunnen het beste bestudeerd worden in een algemene bevolkingsstudie omdat dan geen duidelijke selectiebias optreedt. Zulke studies zijn echter schaars. Dit bemoeilijkt klinische besluitvorming omtrent monitoring en onderhoudsbehandeling. DOEL Presenteren van bevindingen uit de Netherlands Mental Health Survey and Incidence Study-2 (nemesis-2) over terugval en chroniciteit van mdd in de algemene bevolking en risico-indicatoren daarvan. METHODE Bij aanvang werden twee verschillende groepen respondenten geselecteerd om terugval en chroniciteit op één van de twee vervolgmetingen te onderzoeken. dsm-iv-diagnosen werden bepaald met het Composite International Diagnostic Interview (cidi) 3.0. RESULTATEN Van degenen met een mdd in remissie (n = 746), was het cumulatief terugvalpercentage 4,3% na 5 jaar, 13,4% na 10 jaar, en 27,1% na 20 jaar. Tijd tot terugval was geassocieerd met kwetsbaarheidskenmerken (kindermishandeling, negatieve levensgebeurtenissen en ouderlijke psychiatrische stoornissen), lichamelijke gezondheid, functioneren, klinische kenmerken van de depressie (eerdere episoden, ernst en gebruik van psychotrope medicatie), psychiatrische comorbiditeit en zorggebruik vanwege psychische problemen. Van de mensen met een actuele mdd (n = 242) kreeg 12% een chronische depressie binnen 6 jaar. Chronisch beloop was geassocieerd met vergelijkbare risico-indicatoren als van terugval, met uitzondering van kwetsbaarheidskenmerken en lichamelijke gezondheid. CONCLUSIE Met de gevonden risico-indicatoren kunnen patiënten met een depressie worden geïdentificeerd die monitoring behoeven en mogelijk baat hebben bij preventieve interventies of onderhoudsbehandeling

Published
2019

97. Reasoning bias, working memory performance and a transdiagnostic phenotype of affective disturbances and psychotic experiences in the general population

Author

Reininghaus, Ulrich, Rauschenberg, Christian, ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Simons, Claudia J. P., Gunther, Nicole, Pries, Lotta-Katrin, Guloksuz, Sinan, Radhakrishnan, Rajiv, Bak, Maarten, van Os, Jim, Reininghaus, Ulrich, Rauschenberg, Christian, ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Simons, Claudia J. P., Gunther, Nicole, Pries, Lotta-Katrin, Guloksuz, Sinan, Radhakrishnan, Rajiv, Bak, Maarten, and van Os, Jim

Published
2019

98. Interaction between environmental and familial affective risk impacts psychosis admixture in states of affective dysregulation

Author

Radhakrishnan, Rajiv, Guloksuz, Sinan, ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Gunther, Nicole, Rauschenberg, Christian, Reininghaus, Ulrich, Pries, Lotta-Katrin, Bak, Maarten, van Os, Jim, Radhakrishnan, Rajiv, Guloksuz, Sinan, ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Gunther, Nicole, Rauschenberg, Christian, Reininghaus, Ulrich, Pries, Lotta-Katrin, Bak, Maarten, and van Os, Jim

Published
2019

100. Childhood maltreatment, vulnerability characteristics and adult incident common mental disorders: 3-year longitudinal data among >10,000 adults in the general population

Author

Leerstoel Finkenauer, Youth in Changing Cultural Contexts, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Tuithof, Marlous, Kleinjan, Marloes, Penninx, Brenda W J H, Leerstoel Finkenauer, Youth in Changing Cultural Contexts, Ten Have, Margreet, de Graaf, Ron, van Dorsselaer, Saskia, Tuithof, Marlous, Kleinjan, Marloes, and Penninx, Brenda W J H

Published
2019

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