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Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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This paper introduces a disinfection device for ICU nursing, which achieves the goal of integrated disinfection and drying of medical devices after use. During disinfection, the disinfectant can uniformly act on the surface of medical devices, drying quickly, and is conducive to use. (本研究介绍一种ICU护理用消毒装置, 能够达到医疗器械使用后消毒、烘干一体化效果, 且消毒时消毒液能够均匀作用于医疗器械表面, 干燥快速, 有利于提高消毒效率。)

目的探讨微小RNA（miR）-96-5p通过靶向叉头状转录因子O1（FOXO1）基因对子宫内膜癌细胞增殖和侵袭的影响。方法qRT-PCR检测正常组织和子宫内膜癌组织中miR-96-5p和FOXO1 mRNA的表达，Western blot法检测FOXO1蛋白表达。分析miR-96-5p及FOXO1表达与子宫内膜癌临床病理特征的关系。转染pcDNA、pcDNA-FOXO1、inhibitor NC、miR-96-5p inhibitor、miR-96-5p mimic、miR-96-5p + FOXO1到子宫内膜癌Ishikawa细胞，分别记为pcDNA组、FOXO1组、inhibitor NC组、miR-96-5p inhibitor组、miR-96-5p组、miR-96-5p + FOXO1组，对照组不进行转染。取稳定转染的各组细胞，CCK-8和Transwell小室检测细胞活力和侵袭能力，Western blot检测细胞周期蛋白D1（Cyclin D1）、活化多聚ADP核糖聚合酶（cleaved PARP）、p21及波形蛋白的表达水平。TargetScan网站预测miR-96-5p与FOXO1的靶向关系，双荧光素酶报告基因检测细胞荧光素酶活性。Ishikawa细胞分为mimic NC组、miR-96-5p组、inhibitor NC组、miR-96-5p inhibitor 组，qRT-PCR检测各转染组miR-96-5p和FOXO1 mRNA的表达，Western blot法检测FOXO1 蛋白表达。结果子宫内膜癌组织中miR-96-5p的相对表达量较正常组织上调，相反，FOXO1 mRNA和蛋白相对表达量下调（PP=0.034，P=0.010），与年龄和是否绝经无明显相关性（P=0.370，P=0.166）； FOXO1低表达与病理分级和临床分期呈负相关（P=0.023，P=0.007），与年龄和是否绝经无明显相关性（P=0.344，P=0.144）。过表达FOXO1或抑制miR-96-5p表达后，Ishikawa细胞活力明显降低（PPPPPPPP

目的研究促性腺激素释放激素拮抗剂（GnRH-ant）方案中应用加尼瑞克1、加尼瑞克2与西曲瑞克抑制内源性黄体生成素（LH）峰的差异及对临床妊娠结局的影响。方法回顾性分析中山大学附属第三医院生殖医学中心2019年10月-2020年12月应用GnRH-ant方案行体外受精/卵胞质内单精子注射（IVF/ICSI）助孕患者共1 434个周期，根据使用拮抗剂药物不同分为3组。1组：加尼瑞克1组（461周期），2组：加尼瑞克2组（741周期），3组：西曲瑞克组（232周期），分析比较3组患者基本资料、促排卵过程及临床妊娠结局。结果3组患者年龄、体质量指数、抗缪勒管激素等一般资料无差异；3组患者获卵数、扳机日LH>10 U/L所占比例、中重度卵巢过度刺激综合征（OHSS）发生率、成熟卵子数、新鲜胚胎移植临床妊娠率及活产率差异均无统计学意义（P > 0.05）。加尼瑞克1组早期流产率显著高于加尼瑞克2组（21.5% vs. 9.7%，P < 0.05）。结论3种拮抗剂在GnRH-ant方案中扳机日早发LH峰发生率、中重度OHSS发生率、临床妊娠率及活产率相似，但新鲜移植周期加尼瑞克1组早期流产率升高，其不良妊娠结局风险可能增加。

通过向高脂血症模型小鼠灌胃辣木籽提取物，研究辣木籽提取物对高脂血症小鼠血脂及肝脏的影响。将60 只KM小鼠按体质量随机分为正常组，模型组，辛伐他汀组(1 mg/kg)，辣木籽提取物低(5 mg/kg)、中(10 mg/kg)、高(20 mg/kg)剂量组，每组10 只。除正常组饲喂基础饲料外，其余各组小鼠以高脂饲料连续喂养。实验第6周开始，除正常组和模型组外，其余各组小鼠灌胃给予相应药物，连续3周。实验结束后测定各组小鼠血清HDL-C、LDL-C、 TG、TC水平；剖取肝脏，测定肝脏指数并进行病理形态学观察；采用免疫组化法检测肝脏组织法尼酯X受体（FXR）蛋白的表达水平。结果表明：低、中、高剂量辣木籽提取物可显著降低高脂血症小鼠血清TG、TC及LDL-C水平（p

为阐明浸出油茶籽油精炼前后化学成分和抑菌活性的变化规律,采用甲醇对不同精炼阶段油茶籽油进行萃取，通过打孔法研究了不同精炼阶段的油茶籽油及其甲醇萃取液和甲醇萃取余相的抑菌活性，采用超高效液相色谱-四极杆-飞行时间质谱(UPLC-Q-TOF-MS)对精炼前后油茶籽油甲醇萃取液化学成分进行了定性分析，以SIMCA 16.1软件进行主成分分析（PCA）、正交偏最小二乘法-判别分析（OPLS-DA）、变量重要性投影分析（VIP）和t检验，寻找显著变化的差异性成分。结果表明，不同精炼阶段的油茶籽油及其甲醇萃取液具有较好的抑菌作用，且甲醇萃取液的抑菌活性优于相应油茶籽油，而甲醇萃取余相没有抑菌活性，此外，油茶籽油及其甲醇萃取液抑菌活性随着精炼程度的加深呈减弱的趋势。浸出油茶籽油甲醇萃取液中鉴定出47个化学成分，包括油酸、亚油酸等不饱和脂肪酸和以3-对香豆酰基奎宁酸为主的酚类成分，其中油酸、亚油酸、儿茶素类化合物、绿原酸、葛根素、α-生育酚和胡萝卜素等20个成分在精炼后明显降低或者消失。油茶籽油精炼前后化学成分变化明显，抑菌活性也显著降低，根据成分分析结果和抑菌活性考察推测油茶籽油中的抑菌活性物质可能是儿茶素衍生物、绿原酸、葛根素、胡萝卜素、α-生育酚和3-对香豆酰基奎宁酸等成分。 [WTBZ〗In order to elucidate the change rule of chemical components and antibacterial activity of solvent extracted oil-tea camellia seed oil before andafter refining, methanol was used to extract the oil-tea camellia seed oil prepared with different refining processes. The punch method was used to analyze the antibacterial activity of oil-tea camellia seed oil prepared with different refining processes, its methanol extract and methanol extraction raffinate. Ultra performance liquid chromatography-quadrupole-time of flight-mass spectrometry(UPLC-Q-TOF-MS) was used for the qualitative analysis of chemical components in the methanol extract of oil-tea camellia seed oil before and after refining．SIMCA 16.1 software was used for principal component analysis(PCA), orthogonal partial least squares discriminant analysis(OPLS-DA), variable importance projection analysis(VIP) and t-test to identify the components with significant changes. The results showed that the oil-tea camellia seed oil and its methanol extracts of different refining stages had good antibacterial effects, and the antibacterial activity of the methanol extract was better than that of oil-tea camellia seed oil, while the methanol extraction raffinate had no antibacterial activity. In addition, the antibacterial activity of oil-tea camellia seed oil and its methanol extract tended to weaken as the degree of refining deepening. A total of 47 chemical components were characterized in the methanol extract of solvent extracted oil-tea camellia seed oil, including unsaturated fatty acids such as oleic acid and linoleic acid and phenols mainly 3-p-coumaroyl quinic acid. A total of 20 components like the oleic acid and linoleic acid, catechin compounds, chlorogenic acid, puerarin, α-tocopherol and carotene decreased significantly or disappeared after refining. The research found that there were significant differences in the chemical components of oil-tea camellia seed oil before and after refining, and its antibacterial activity was also obviously diminished. It is speculated that catechin derivatives, chlorogenic acid, puerarin, carotene, α-tocopherol and 3-p-coumaroyl quinic acid might be the antibacterial active substances of oil-tea camellia seed oil according to the results of the components analysis and the examination of the antibacterial activity.

近年来，机器学习等人工智能技术被应用于蛋白质工程，其在蛋白质结构、功能预测、催化活性等研究中具有独特优势。在未知蛋白质结构的情况下，将蛋白质序列和功能特性与机器学习相结合，基于序列-活性关系（innovative sequence-activity relationship，ISAR）算法，将蛋白质氨基酸序列数字化，用快速傅里叶变换（fast four transform，FFT）进行预处理，再进行偏最小二乘回归建模，可在数据集较少情况下拟合得到最佳模型。通过机器学习对紫色球杆菌视紫红质（gloeobacter violaceus rhodopsin，GR）的突变体蛋白质氨基酸序列与光谱最大吸收波长进行建模，获得了最佳模型。用最佳索引LEVM760106建模得到的确定系数R2为0.944，均方误差E为11.64。用小波变换进行的预处理，其R2虽也约为0.944，但E大于11.64，不及FFT进行的预处理。方法较好地解决了蛋白质序列与功能特性之间的数学建模问题，在蛋白质工程中可为预测更优的突变体提供支持。

为了确定酶解法制备家蝇蛹多肽（PHP）的工艺条件，并初步评价PHP的促伤口愈合活性，以家蝇（Musca domestica L.）蛹为原料，采用蛋白酶酶解法制备PHP，通过单因素实验优化酶解法制备PHP的工艺条件，并在细胞水平上评价PHP的促伤口愈合活性。结果表明，10种蛋白酶酶解法制备的PHP中，胃蛋白酶酶解法制备的PHP得率最高，其次是风味蛋白酶酶解法制备的PHP（PHF）。另外，PHF的多肽含量及水解度均最高。单因素实验结果表明，制备PHF的最佳条件为酶解温度60 ℃、加酶量8 000 U/g、酶解时间4 h，在此条件下制得的PHF得率最高、水解最完全。细胞实验结果显示，不同蛋白酶酶解法制备的PHP具有不同程度促进HaCaT细胞增殖及迁移的作用。其中，PHF（分子质量主要分布在500~1 300 Da之间）促伤口愈合活性最佳。同时，PHF可显著促进RAW264.7细胞转化生长因子TGF-β1及炎性细胞因子TNF-α、IL-6的表达。综上，风味蛋白酶酶解法是一种制备高得率、高多肽含量及高水解度的PHP的方法，PHF具有促进伤口愈合的潜力。In order to determine the process conditions for preparing peptides from housefly pupa (PHP) using enzymolysis method and evaluate the wound healing-promoting activity of PHP, PHP were prepared with enzymolysis methods using pupa of Musca domestica L. as the raw material. The single factor experiment was designed to optimize the preparation process of PHP and the wound healing-promoting activity of PHP was studied at the cellular level. The results showed that among the PHP prepared with ten proteases, the yield of PHP prepared with pepsin was the highest, followed by flavourzyme hydrolysis (the peptide was referred to as PHF). In addition, PHF showed the highest peptides content and degree of hydrolysis. The results of single factor experiment displayed that PHF presented the highest yield and degree of hydrolysis under the conditions of temperature 60 ℃, enzyme dosage 8 000 U/g, and time 4 h. Besides, PHP prepared with different proteases had different degrees of promoting proliferation and migration of HaCaT cells, among them, PHF (molecular weight mainly distributed between 500 Da and 1 300 Da) exhibited the best wound healing-promoting activity. Meantime, PHF significantly promoted the expression of transforming growth factor TGF-β1 and inflammatory cytokines TNF-α, IL-6 in RAW264.7 cells. In conclusion, the enzymolysis method with flavourzyme contributes to prepare PHP with high-yield, high-peptides content, and high-degree of hydrolysis, and PHF has the potential to promote wound healing.

Reversible cerebral vasoconstriction syndrome (RCVS) is a kind of cerebrovascular disease. Headache due to RCVS is relatively common in RCVS patients, and the pathogenesis is not yet clear. In this paper, headache due to RCVS may be related to vascular dystonia and endothelial dysfunction, and early identification of the disease on the basis of clinical manifestations and differential diagnosis is conductive to the prognosis of the disease. 可逆性脑血管收缩综合征（reversible cerebral vasoconstriction syndrome，RCVS）是一种脑血管疾病，霹雳性头痛是其最主要的临床表现。缘于RCVS的头痛发病机制尚未明确。本文介绍了缘于RCVS的头痛可能与血管张力失调和内皮功能障碍有关，同时从临床表现和鉴别诊断方面进行疾病的早期识别，从而早期干预以利于疾病的预后转归。 缘于RCVS的头痛的发病机制与血管张力失调和内皮功能障碍有关，难点在于对霹雳性头痛的识别诊断，探讨其发病机制和掌握鉴别诊断，有利于疾病的早诊早治。

Objective To investigate the practice effect of PDCA cycle in improving the qualified rate of standard processing for precision instruments. Methods Totally 4870 pieces of precision instruments processed through a routine management procedure were included as the control group, another 4372 pieces of precision instruments processed through a PDCA cycle were included as the study group. The qualified rate of standard processing was calculated and compared between groups. Results The qualified rate of standard processing was 99. 02%(4329/4372) in the study group, which was higher than 91. 97%(4479/4870)in the control group(P＜0. 01). Conclusion The PDCA cycle is effective to improve the qualified rate of standard processing for precision instruments. It is of great significance for improving surgical nursing quality, ensuring patient safety, prolonging service life of instruments and making full use of medical resources. (目的 探讨运用PDCA循环提高精密器械处置规范率的效果。方法 选取2021年5月—6月消毒供应中心接收的4870件精密器械作为对照组, 采用常规管理流程进行处理; 选取2021年9月—10月接收的4372件精密器械作为试验组, 采用PDCA循环管理方法进行处理, 比较两组精密器械处理规范率。结果 试验组精密器械处理规范率为99. 02%(4329/4372), 对照组器械处置规范率为91. 97%(4479/4870), 差异有统计学意义(P＜0. 01)。结论 应用PDCA循环法能够有效提高精密器械的处理规范率, 对提高手术质量、保证患者安全、延长器械寿命、充分发挥医疗资源具有重要意义。)

BACKGROUND: Ferroptosis is a mode of programmed cell death distinct from apoptosis, necrosis, and other novel cellular deaths, which occurs mainly due to accumulated lipid peroxidation. Ferroptosis has been shown to be involved in the pathological process following subarachnoid hemorrhage. Baicalein, serving as an adept sequestered of iron, evinces its prowess by quelling lipid peroxidative cascades. Nonetheless, the enigma lingers as to whether baicalein possesses the capacity to ameliorate neuronal ferroptosis, elicited in the wake of early brain injury after subarachnoid hemorrhage. OBJECTIVE: To investigate the effect and mechanism of baicalein on neuronal ferroptosis after subarachnoid hemorrhage. METHODS: Primary neuronal cells were extracted from C57BL/6L fetal mice at 16-17 days of gestation. Hemoglobin was used to stimulate primary neuronal cells to simulate an in vitro subarachnoid hemorrhage model. The viability of primary neuronal cells treated with baicalein at concentrations of 5, 15, 25, 50, and 100 μmol/L for 24 hours was detected by CCK-8 assay to determine the optimal concentration of baicalein. Primary neuronal cells were divided into control group, hemoglobin group, and hemoglobin+baicalein group. The levels of reactive oxygen species and malondialdehyde in cells were detected by kits. The mRNA expressions of ferroptosis-related markers PTGS2, SLC7A11, and glutathione peroxidase 4 were detected by RT-PCR. The primary neuronal cells were further divided into control group, SLC7A11 inhibitor Erastin group, hemoglobin group, hemoglobin+baicalein group, and hemoglobin+baicalein+Erastin group. The expression of the ferroptosis related markers SLC7A11 and glutathione peroxidase 4 was detected by western blot assay. RESULTS AND CONCLUSION: (1) Baicalein (25 μmol/L) was selected as the following experimental concentration. (2) Compared with the hemoglobin group, the level of malondialdehyde and the level of reactive oxygen species were significantly decreased (P < 0.05) in the hemoglobin+baicalein group. (3) Compared with the hemoglobin group, the mRNA expression of PTGS2 significantly decreased, and the mRNA expression of SLC7A11 and glutathione peroxidase 4 significantly increased (P < 0.000 1) in the hemoglobin+baicalein group. (4) SLC7A11 inhibitor Erastin could reverse the baicalin-improved ferroptosis effect to a certain extent (P < 0.05). (5) The results showed that baicalein could alleviate the ferroptosis of neuronal cells after subarachnoid hemorrhage through the SLC7A11/ GPX4 pathway. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper summarized the nursing measures of a patient with grade 2 phlebitis treated with Traditional Chinese Medicine collapse stains. The nursing assessment, application method and cautions of collapse stains, composition of Chinese herbs, dietary guidance and psychological intervention were reviewed. Through the active intervention of the external treatment of Traditional Chinese Medicine, the level of phlebitis decreased, pain was relieved, and good results were achieved. (本文总结1例中药塌渍治疗静脉炎患者的护理措施和体会, 包括护理评估、中药塌渍操作方法、药方组成、注意事项以及饮食指导、心理干预等护理措施。基于辨证施护理念。通过中药塌渍外治法积极干预, 并辅以相关护理措施, 患者静脉炎症状明显好转, 疼痛减轻。)

基于模块化多电平换流器的高压直流输电技术迅速发展，直流侧短路故障电流的限制与开断困难等问题已然成为研究热点。故障限流技术能够快速限制短路电流的峰值与上升率，为直流断路器的快速隔离提供有利条件。在现有混合式直流断路器基础上，提出2种快速限流的技术方案：新型直流故障限制器与直流断路器配合方案、结合限流电路的混合直流断路器方案。通过限流电感实现故障初期对故障电流上升率的抑制、限流电阻和电容在故障过程中快速投入以及电感限流回路与电容放电回路引入，使得故障电流峰值降低，直流断路器中避雷器的耗能压力继而减小，最终实现直流侧故障电流的快速清除。最后，利用PSCAD/EMTDC仿真验证方案的可行性。研究结果表明，所提2种方案能够大幅度减小故障电流峰值、降低避雷器耗能以及实现直流断路器安全可靠分断。

This paper reviewed the nursing measures based on the idea of "heterozygous treatment" for a patient in the face-down position after vitrectomy. A comprehensive treatment with various methods, including psychological care, position management, complication prevention and Traditional Chinese Medicine nursing techniques, were carried out to improve the postoperative rehabilitation and quality of life of the patient. (本文回顾“杂合以治”思想应用于1例玻璃体切割术后面向下体位患者的护理体会。基于“杂合以治”思想, 采用多种方法给予患者对症综合治疗, 对促进术眼康复和提高患者生活质量有积极作用。)

为有效提高食用植物油中麦芽酚、乙基麦芽酚、香兰素、甲基香兰素和乙基香兰素的检测效率，建立同时测定食用植物油中麦芽酚、乙基麦芽酚、香兰素、甲基香兰素和乙基香兰素的液相色谱-串联质谱(HPLC-MS/MS)检测方法。样品经乙腈提取，正己烷脱脂后，采用甲醇-0.1%甲酸水溶液作为流动相进行梯度洗脱，质谱电喷雾离子源在正离子模式下进行多反应监测扫描，对5种香料进行定量测定。结果表明，5种香料质量浓度与峰面积线性关系良好,相关系数均大于0998, 方法检出限为2.3~19.5 μg/kg，定量限为7.7~65.0 μg/kg，回收率在85.0%~107.8%之间,相对标准偏差均小于50%。该方法操作简便、定性定量准确、灵敏度高，适用于食用植物油中麦芽酚、乙基麦芽酚、香兰素、甲基香兰素和乙基香兰素的同时测定，可有效提高检测效率。 In order to effectively improve detection efficiency of maltol, ethyl maltol, vanillin, methyl vanillin and ethyl vanillin in edible vegetable oil, a liquid chromatography-mass spectrometry (HPLC-MS/MS) method was established for the simultaneous determination of maltol, ethyl maltol, vanillin, methyl vanillin and ethyl vanillin in edible vegetable oil.The samples were extracted by acetonitrile and defatted by n-hexane,then methanol-0.1% formic acid aqueous solution was used as the mobile phase for gradient elution, electrospray ionization was used to conduct multiple reaction monitoring scanning under positive ion mode, and 5 kinds of spices were quantitatively determined. The results showed that the linear relationships were good between the mass fraction of spices and peak areas, and the correlation coefficients were higher than 0.998,the detection limits were 2.3-19.5 μg/kg, the quantitation limits were 7.7-65.0 μg/kg,the recovery rate were 85.0%-107.8%, and the relative standard deviations were less than 5.0%.The method is simple, accurate and sensitive. It is suitable for the simultaneous determination of maltol, ethyl maltol, vanillin, methyl vanillin and ethyl vanillin in edible vegetable oil, which can improve the detection efficiency effectively.

This paper reviewed the effective nursing interventions for a case of severe pneumonia complicated with respiratory failure treated by mechanical ventilation. A set of interventions including mechanical ventilation nursing, medication nursing, enteral nutrition support, catheter maintenance, skin care and psychological nursing were carried out, aiming to relieve the symptoms of respiratory failure, alleviate patient’s condition and reduce the complications. (本文总结机械通气治疗1例重症肺炎合并呼吸衰竭患者的护理干预措施, 主要从机械通气护理、用药护理、肠内营养支持、管路护理、皮肤护理及心理护理等方面进行护理干预, 旨在改善患者呼吸衰竭状况和各项生命体征, 控制重症肺炎病情, 减少并发症的发生。)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the relationship between serum leucine 2-rich glycoprotein 1 （LRG1）， lactate dehydrogenase （LDH） with periodontal indicators and periodontal lesions degree in patients with type 2 diabetes mellitus （T2DM） and chronic periodontitis （CP）. Methods 112 patients with T2DM combined with CP admitted to our hospital from July 2022 to July 2023 （T2DM combined with CP group） were selected and categorized into mild， moderate， and severe groups according to the degree of periodontal pathology； 112 patients with CP alone （CP group） were selected from our hospital during the same period， and then 112 patients with T2DM alone （T2DM group） were selected； and LRG1， LDH， and periodontal indexes were measured； Pearson method was applied to analyze the correlation between serum LRG1， LDH， and periodontal indicators. The influencing factors of severe T2DM combined with CP were analyzed using multivariate logistic regression. ROC curve was plotted to analyze the diagnostic value of serum LRG1 and LDH for severe T2DM combined with CP. Results The levels of LRG1 and LDH in the CP group， T2DM group， and T2DM combined with CP group increased sequentially （P < 0.05）. The levels of serum LRG1， LDH， AL， PD， and BI increased sequentially in the mild， moderate， and severe groups （P < 0.05）. According to Pearson correlation analysis， serum LRG1 was positively correlated with LDH （P < 0.05）. Serum LRG1 and LDH were positively correlated with AL， PD， and BI （P < 0.05）. According to logistic regression analysis， LRG1， LDH， AL， PD， and BI were all factors for severe T2DM combined with CP （P < 0.05）. According to the ROC curve， the AUC for the combined diagnosis of serum LRG1 and LDH in severe T2DM with CP was 0.910， and the combination of the two was better than their individual diagnosis （Z combination vs LRG1= 2.659， Z combination vs LDH=2.627， P < 0.05）. Conclusion LRG1 and LDH are greatly elevated in the serum of patients with T2DM combined with CP， and they are related to periodontal indicators and the periodontal lesions degree. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Rural research travel is an important part of modern research travel system. The development of rural education lags behind especially in western areas. Taking the western countryside as an example, the development of rural study and travel courses is of great significance to rural education and tourism development. Based on the latest educational concept, combined with the field characteristics of rural areas, in order to promote the development of rural resources and improve the quality of rural research curriculum, the connotation and concept of rural research curriculum development are put forward. Three elements of curriculum resources development of rural studies are put forward, which are curriculum material resources, scene resources and human resources. Curriculum design can be divided into six aspects: curriculum theme, curriculum objectives, curriculum content, curriculum implementation, curriculum evaluation and curriculum management. Taking Langjie Village in Yuzhong County as an example, the application method of combining theory with practice is illustrated in order to provide theoretical and case reference for the development of rural research travel curriculum. [ABSTRACT FROM AUTHOR]

BACKGROUND: Osteoporosis has a high incidence, leading to fracture and other complications. However, existing drugs have great side effects and are difficult to meet the clinical application. OBJECTIVE: To explore the effect and potential mechanism of fucoxanthin on osteoporosis induced by glucocorticoid. METHODS: Primary rat osteoblasts were inoculated in 6-well plates. When the cell fusion reached 80%, the cells were divided into four groups: the control group was cultured alone for 24 hours, the glucocorticoid group was intervened with dexamethasone for 24 hours, the fucoxanthin group was intervened with fucoxanthin for 24 hours, and the glucocorticoid + fucoxanthin group was intervened with dexamethasone and fucoxanthin at the same time for 24 hours. After intervention, cell proliferation, apoptosis, intracellular reactive oxygen species level, and protein expression of apoptosis-related proteins, bone formationrelated proteins, and nuclear factor erythroid-2-related factor 2 were detected. RESULTS AND CONCLUSION: Cell counting kit-8 results showed that the cell viability was decreased in the glucocorticoid group compared with the control group (P < 0.05) but increased in the glucocorticoid+fucoxanthin group compared with the glucocorticoid group (P < 0.05). JC-1 mitochondrial membrane potential staining and flow cytometry assay showed that the percentage of apoptosis increased in the glucocorticoid group compared with the control group (P < 0.05) but decreased in the glucocorticoid+fucoxanthin group compared with the glucocorticoid group (P < 0.05). Western blot assay showed that compared with the control group, the protein expression of BAX and cleaved poly (ADP-ribose) polymerase was elevated in the glucocorticoid group (P < 0.05), and the protein expression of BCL2, type I collagen α1 peptide chain, alkaline phosphatase, osteocalcin, and RUNX2 was decreased in the glucocorticoid group (P < 0.05). Compared with the glucocorticoid group, the protein expression of BAX and cleaved poly (ADP-ribose) polymerase was decreased (P < 0.05), and the protein expression of BCL2, type I collagen α1 peptide chain, alkaline phosphatase, osteocalcin, and RUNX2 was elevated (P < 0.05) in the glucocorticoid+fucoxanthin group. Fluorescent probe assay showed an increase in reactive oxygen species level in the glucocorticoid group compared with the control group (P < 0.05) and a decrease in reactive oxygen species level in the glucocorticoid+fucoxanthin group compared with the glucocorticoid group (P < 0.05). Immunofluorescence staining and western blot assay showed that the protein expression of nuclear factor erythroid-2-related factor 2 in the glucocorticoid group was decreased compared with that in the control group (P < 0.05); and the protein expression of nuclear factor erythroid-2-related factor 2 in the glucocorticoid+fucoxanthin group was elevated compared with that in the glucocorticoid group (P < 0.05). To conclude, fucoxanthin can improve glucocorticoid-induced osteoblast apoptosis and the expression of bone formation-related molecules by activating nuclear factor erythroid-2-related factor 2. [ABSTRACT FROM AUTHOR]

The experiments were conducted to study the effects of dietary inulin supplementation on growth performance, slaughter performance, organ index and meat quality of weaned lambs. Thirty 60- day-old Leizhou goat lambs with similar body condition were randomly divided into 4 groups: control group (basic diet), trial group Ⅰ (basic diet +0.1% inulin), trial group Ⅱ (basic diet +0.3% inulin) and trial group Ⅲ (basic diet +0.5% inulin) with 6 replicates per group and 1 sheep per replicate. The pre-test period lasted for 7 days and the formal period for 40 days. The test results showed as follows: ① compared with group C, the ratio of feed to gain (FCR) in test groups Ⅱ and Ⅲ was significantly decreased (P< 0.05); The average daily gain (ADG) and average daily feed intake (ADFI) in trial group Ⅱ were significantly increased (P<0.05). ② The carcass weight of trial group Ⅱ and slaughter rate of trial group Ⅲ were significantly increased compared with group C (P<0.05); the GR value of trial groups Ⅰ, Ⅱ and Ⅲ was significantly higher than that of group C (P<0.05), but there was no significant difference in GR value among groupsⅠ, Ⅱ and Ⅲ (P>0.05). ③ Spleen mass in test group Ⅲ was significantly higher than that in group C (P<0.05), but no significant difference was found in organ index among other groups (P>0.05). ④ The shear force of test groups Ⅰ, Ⅱ and Ⅲ was significantly lower than that of group C (P<0.05), and there was no significant difference in pH1h of test groups Ⅰ, Ⅱ and Ⅲ (P>0.05), but there was a significant difference compared with group C (P<0.05). The cooking loss in test group Ⅲ was significantly lower than that in group C (P< 0.05). There were no significant differences in pH24h, brightness L*, redness a* and yellowness b* among other groups (P>0.05). In conclusion, adding inulin to the diet can improve the growth performance and slaughter performance of weaned lambs, reduce the feed to gain ratio, increase the spleen index and improve the meat quality. Under the conditions of this experiment, the appropriate dosage of inulin in the diet was 0.3%. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)