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Copyright of Journal of National University of Defense Technology / Guofang Keji Daxue Xuebao is the property of NUDT Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ballistics / Dandao Xuebao is the property of Journal of Ballistics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective This study aimed to investigate the causal relationship between saturated fatty acids (SFA) and cardiovascular disease (CVD). Methods A two-sample Mendelian randomization (MR) design was adopted, using genetic variants associated with SFA as instrumental variables, and extracting coronary heart disease, atrial fibrillation, heart failure, ischemic stroke, and 10 cardiovascular risk factors as main outcome indicators from GWAS datasets. The inverse-variance weighted method (IVW) was used as the primary analytical approach, and sensitivity analyses including heterogeneity test, horizontal pleiotropy test, and leave-one-out test were performed to assess the robustness of the MR findings. Results Our results revealed a significant causal association between SFA and coronary heart disease (OR：1.30, 95%CI: 1.15-1.46, P=1.46×10-5), total cholesterol (OR:2.02, 95%CI:1.86-2.18, P=6.71×10-67), low-density lipoprotein cholesterol (OR:1.46, 95%CI:1.39-1.54, P=2.29×10-46) and triglycerides (OR:2.22, 95%CI:2.03-2.42, P=4.43×10-72). However, we did not observe any significant causal effects between SFA and other cardiovascular or risk factors. Conclusion SFA has a causal relationship with coronary heart disease and blood lipid levels, which provides evidence for the dietary prevention of cardiovascular disease by SFA. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the efficacy of Cangfu Daotan Pill on phlegm dampness type polycystic ovary syndrome (PCOS) and its influence on the phosphatidylinositol-3-kinase (PI3K) /protein kinase B (AKT) signaling pathway in peripheral blood. Methods: 86patients with phlegm dampness type PCOS who were admitted to Cangzhou Integrated Traditional Chinese and Western Medicine Hospital of Hebei Province from January 2022 to October 2022 were included. According to the random number table method, they were divided into control group (n=43, treated with Diane-35) and experimental group (n=43, treated with Diane-35 combined with Cangfu Daotan Pill) . The traditional Chinese medicine syndrome scores, sex hormone indicators, glucose and lipid metabolism indicators,PI3K/AKT signaling pathway related indicators changes and the incidence of adverse reactions were observed in two groups. Results:Compared with control group after treatment, experimental group had lower traditional Chinese medicine syndrome scores, triglyceride (TG), follicle stimulating hormone (FSH), low-density lipoprotein cholesterol (LDL-C), testosterone (T), luteinizing hormone (LH), fasting blood glucose (FBG), total cholesterol (TC), fasting insulin (FINS) levels and lower PI3K messenger ribonucleic acid (m RNA), AKT m RNA, and higher high-density lipoprotein cholesterol (HDL-C) (P＜0.05) . There was no difference in the incidence of adverse reactions between two groups (P＞0.05) . Conclusion: Cangfu Daotan Pill is used to treat patients with phlegm dampness type PCOS, which can effectively regulate sex hormones and glucose and lipid metabolism indicators, improve clinical symptoms, may be related to regulating the PI3K/AKT signaling pathway in peripheral blood. [ABSTRACT FROM AUTHOR]

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Henan University of Technology Natural Science Edition is the property of Henan University of Technology Journal Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Engineering Science Research & Application is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Urban Architecture & Development is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

With the continuous development of hypersonic aircraft towards high Mach and wide speed domains, the propulsion system faces low dynamic pressure working conditions, leading to a huge challenge to the flow mixing in the combustion chamber. The influence mechanism of hydrocarbon fuel preheating on supersonic shear mixing characteristics in the scramjet combustor was studied, and the influence of temperature and hydrocarbon fuel pyrolysis on mixing characteristics was analyzed. It is found that the preheating of non-cracking hydrocarbon fuel will enhance the viscous dissipation of the jet and reduce the mixing efficiency. When the fuel temperature increases from 750 K to 900 K, the mixing efficiency of the combustion chamber will decrease by nearly 5%, and the total pressure loss will increase by about 20%. However, the thermal cracking reaction of hydrocarbon fuel has a dual effect on the shear mixing. The expansion performance of the cracked hydrocarbon fuel is improved, and the mixing efficiency near the nozzle is increased by about 18%； However, due to the decrease in turbulent kinetic energy of the fluid in the shear layer, the mixing efficiency decreases by about 6% at a position far from the nozzle. [ABSTRACT FROM AUTHOR]

Copyright of Acta Agronomica Sinica is the property of Crop Science Society of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Asian Journals of Ecotoxicology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of University Chemistry is the property of Peking University, College of Chemistry & Molecular Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Central China Normal University is the property of Huazhong Normal University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Weapon target assignment (WTA) problem is an important problem in the field of combat command and decision-making, which aims to determine a reasonable weapon allocation scheme for the target to be attacked based on the different damage probability of the weapon to the incoming target, in order to achieve the goal of minimizing the damage degree of the weapon to the incoming target. Based on the construction of WTA problem model, an elite retention and immune mutation local search strategy was adopted in grey wolf optimization (GWO) to improve the local search ability of the traditional GWO algorithm. The improved grey wolf optimization (IGWO) firstly selects some high-quality elite individuals from the gray wolf population, and then further optimizes the elite individuals by using two immune local search strategies, random point mutation and receptor editing, to further optimize the elite individuals, thereby improving the shortcomings of premature convergence and easy to fall into local optimization of traditional GWO algorithms. Aiming at three scales of WTA problems, IGWO is compared with the cross entropy algorithm and traditional GWO algorithm, the calculation results show that the quantiles of fitness values obtained by the IGWO algorithm are significantly higher than those of the comparison algorithm, thereby verifying the effectiveness of the IGWO algorithm. [ABSTRACT FROM AUTHOR]

Copyright of Yellow River is the property of Editorial Board of Yellow River and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Yellow River is the property of Editorial Board of Yellow River and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aimed at the problem that valve regulated lead-acid (VRLA) battery aging threatening power supply reliability in cloud data centers, a method of an online battery state prediction method based on machine learning algorithms was proposed. Predicting battery status through classic machine learning algorithm models, comparative experiments were conducted on the prediction accuracy between models without extracted feature values and models with extracted feature values. Compare the prediction accuracy of the model using unrefined feature values with the model extracting feature values. The prediction accuracy of the model without extracted feature values ranges from 71. 72% to 81. 82%, and after extracting feature values, the prediction accuracy has improved by 10. 10% to 20. 20%, extracting feature values can improve prediction accuracy. The prediction model based on linear SVM method for extracting feature values is superior to other algorithms, with an accuracy of 96. 46%. Experiment results show that machine learning algorithm based prediction models can be used for online VRLA battery state prediction in cloud data centers. [ABSTRACT FROM AUTHOR]

Objective: A fetus was suggested the developmental abnormity of skeletal system and suspected growth restriction by prenatal B -ultrasound. To clarify the cause of the disease, genetic detection and bioinformatics analysis were conducted. Methods: gDNAs were extracted from the amniotic fluid of proband and the peripheral blood of his parents, respectively. Whole exome sequencing (WES) and copy number variation sequencing (CNV-seq) technique of trio via high-throughput sequencing platforms, and Sanger sequencing were used to verify the likely pathogenic variant. Results: A denovo mutation of c.223C>T (p.R75W) in the fetal high mobility group protein AT-Hook-2 (HMGA2) gene was found. It is a missense mutation, resulting in the change of amino acid to p.R75W (p.Arg75Trp). According to American College of Medical Genetics and Genomics (ACMG), the variant was assessed to be a likely pathogenic variant: PS2 +PM2_Supporting +PP3 +PS4_Supporting. Based on the clinical phenotype, the fetus was diagnosed with an autosomal dominant Silver-Russell syndrome 5 (SRS5). Sanger sequencing confirmed the authenticity of the mutation. Conclusions: The c.223C>T(p.R75W) of HMGA2 gene may be the genetic cause of the heterozygous pathogenic variation, which expands the variant profile of this gene and provides a theoretical basis for prenatal genetic counseling and subsequent interventions in the fetus. [ABSTRACT FROM AUTHOR]

Copyright of Acta Petrologica et Mineralogica / Yanshi Kuangwuxue Zazhi is the property of Acta Petrologica et Mineralogica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Petrologica et Mineralogica / Yanshi Kuangwuxue Zazhi is the property of Acta Petrologica et Mineralogica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Educational Technology is the property of Editorial Board of Modern Educational Technology, Tsinghua University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Distance Education (1672-0008) is the property of Zhejiang Open University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Fudan University Journal of Medical Sciences is the property of Fudan University Journal of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 调整科研项目激励措施, 提升医院职工申报国家自然科学基金项目的积极性和质量. 方法 收集 2010—2021 年某三级甲等医院国家自然科学基金项目的申报与立项数据, 对比 2016 年调整激励 措施前后数据变化, 评价调整激励措施后的效果. 结果 调整措施后, 该医院的国家自然科学基金申报项目数 量明显提高, 且科研人员申报青年科学基金等全国竞争性项目的积极性明显提升, 增长率远大于地区科学基金 项目;立项数量稳中有升, 资助经费明显增长;项目申报结构、立项结构均得到优化;该医院整体科研水平显著 提升. 结论 该院制定的科研项目调整措施效果显著. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This work is aimed to construct a KYSE-150 cell line containing an inducible expressed ERK-SPARK kinase fluorescent sensor into the AAVS1 locus. The homologous recombination donor plasmid of the inducible ERK-SPARK expression cassette with 750 bp homology arms at both ends was constructed according to the DNA sequence design of the AAVS1 locus and the published base sequences of the ERK-SPAEK fluorescent probe. Secondly, three sgRNAs targeting the AAVS1 locus were designed using an online design tool, and cloned into the pX330 backbone plasmid. Three CRISPR/Cas9 targeting vectors capable of site-specific cutting of the AAVS1 locus were obtained. The homologous recombination donor plasmids and the expressed CRISPR/Cas9 targeting vectors were co-transfected into KYSE-150 cells, after Dox-induced expression for 24 h, puromycin resistance screening and flow cytometry were performed, and cell subpopulations resistant to puromycin and expressing GFP were obtained. Then PCR was used to identify the genotype, and Western blot was used to detect protein expression. Genomic DNA was extracted from the obtained cell population and the genotype was identified by PCR. The results showed that the size of the obtained fragment was consistent with the size of the inducible ERK-SPARK expression cassette. The results of protein expression detection showed that the cell population expressed the ERK-SPARK probe fusion protein. The results of fluorescent probe imaging experiments demonstrated that the cell line had a very small amount of leakage expression under the condition of no Dox-induced expression. After Doxinduced expression, the GFP fluorescent protein was evenly distributed in the cytoplasm without obvious aggregation into spots. After adding EGF to activate ERK kinase, the green fluorescence of GFP that was uniformly distributed in the cytoplasm gathered into high-brightness green droplets. A stable cell line that expressed the SPARK fluorescent probe after induction for detecting ERK kinase activity were successfully obtained, which may solve the problem that the unstable efficiency of the transiently expressed ERK-SPARK probe affected the accuracy of the experimental results, and may lay the preliminary research foundation for subsequent establishment of screening platform of a SPARK-based high-throughput protein kinase inhibitors. [ABSTRACT FROM AUTHOR]

Copyright of Electric Power Automation Equipment / Dianli Zidonghua Shebei is the property of Electric Power Automation Equipment Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Forest Research is the property of Forest Research Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Engineering for Thermal Energy & Power / Reneng Dongli Gongcheng is the property of Journal of Engineering for Thermal Energy & Power and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Applied Chemical Industry is the property of Shaanxi Research Design Insitute of Petroleum & Chemical Industry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Biotechnology Bulletin is the property of Biotechnology Bulletin Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Henan Agricultural Sciences is the property of Editorial Board of Journal of Henan Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mechanical & Electronic Control Engineering is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The clinical incubation period of patients infected with SARS-CoV-2 (such as Omicron subtype) seems to be getting shorter and more contagious, with symptoms mainly occurring in the upper respiratory tract. Therefore, at present, the prevention and treatment of upper respiratory virus infection represented by nasal cavity has become the focus of prevention and control. In addition to wearing face mask properly, nasal saline irrigation is suggested as a low cost nasal physical therapy with advantage to reduce viral infection and accelerate the recovery of inflammation with less side effects. It has become one of the economic and effective means to prevent and control SARS-CoV-2 infection. Based on the 2022 Expert consensus on nasal saline irrigation for the prevention of SARS-CoV-2 infection, young and middle-aged rhinologists in the Chinese Rhinology Research Collaboration Group referred to the pathogenic characteristics of SARSCoV- 2 subtypes and evidence-based medical evidence at home and abroad, summarized the clinical experience of epidemic prevention and control, and formulated the Clinical guideline for nasal saline irrigation for the prevention and treatment of SARS-CoV-2 infection (2023 edition), in order to guide clinical prevention and treatment more quickly and effectively. [ABSTRACT FROM AUTHOR]

Objective To evaluate the effect of mesenchymal stem cell (MSC) coated-islets on instant blood-mediated inflammatory reaction (IBMIR) after islet transplantation. Methods MSC labeled with tracer and human islets were placed into an ultra-low adsorption cell culture dish, shaken and mixed twice at an interval of 0.5 h, and then incubated at 37°C and 5% CO2 for 24 h to obtain MSC-coated islets. The coating effect of MSC and in vitro function of the islets were assessed. A blood circulation tube-shaped model was established in vitro. In the blank control group, 0.2 mL of islet culture solution was added. In the islet group, 800 islet equivalent quantity (IEQ) of uncoated islets were supplemented. In the MSC-coated islets group, 800 IEQ of MSC-coated islets were added, and circulated for 60 min at 37°C . A portion of 0.5 mL blood sample was taken for routine blood test at 0, 30 and 60 min, respectively. After 60 min circulation, the blood sample was filtered with a 70 µm filter to collect plasma, blood clots and islets. Blood clots and islets were subject to hematoxylin-eosin (HE) staining and immunohistochemical staining. Morphological changes and the aggregation of CD11b-positive cells surrounding the islets were observed. The contents of plasma thrombin-antithrombin complex (TAT), tissue factor (TF), C3a, C5b-9, interleukin (IL)- 1β, IL-6, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein (MCP)-1 and IL-8 were determined by enzymelinked immune absorbent assay. Results After 24 h co-incubation, the islets were coated by MSC, with a coating degree of approximately 80%. In the islet and MSC-coated islet group, a large quantity of neutrophils and monocytes were observed surrounding the blood clots and islets, and the quantity of CD11b-positive cells in the MSC-coated islet group was less compared with that in the islet group. After co-incubation with the whole blood for 0, 30 and 60 min, the quantity of platelets, neutrophils and monocytes was declined in the MSC-coated and islet groups, and gradually decreased over time. Compared with the blank control group, the quantity of platelets, monocytes and neutrophils was lower, whereas the TF content was higher in the MSCcoated islet group. Compared with the islet group, the quantity of platelets, monocytes and neutrophils was higher, whereas the TAT and TF contents were less in the MSC-coated islet group, the differences were statistically significant (all P<0.05). Compared with the blank control group, the expression levels of C3a, C5b-9, IL-6, TNF-α and IL-8 were up-regulated in the MSC-coated islet group. Compared with the islet group, the expression levels of C3a, C5b-9, IL-1β, IL-6, TNF-α, IL-8 and MCP-1 were down-regulated in the MSC-coated islet group, and the differences were statistically significant (all P<0.05). Conclusions MSC-coated islets may reduce the exposure of islet TF in the blood and prevent the incidence of IBMIR during the coagulation response stage, thereby mitigating the injury and loss of islet allograft in the early stage of islet transplantation. [ABSTRACT FROM AUTHOR]