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113. Estimated model of psychotropic polypharmacy for bipolar disorder: Analysis using patients' and practitioners' parameters in the MUSUBI study.

Author

Adachi, Naoto, Azekawa, Takaharu, Edagawa, Kouji, Goto, Eiichiro, Hongo, Seiji, Kato, Masaki, Katsumoto, Eiichi, Kikuchi, Toshiaki, Kubota, Yukihisa, Miki, Kazuhira, Nakagawa, Atsuo, Tsuboi, Takashi, Ueda, Hitoshi, Watanabe, Koichiro, Watanabe, Yoichiro, Yasui‐Furukori, Norio, and Yoshimura, Reiji

Subjects
*BIPOLAR disorder, *CLINICS, *SOCIAL adjustment, *POLYPHARMACY, *ARIPIPRAZOLE, *PSYCHIATRIC drugs, *MULTIPLE regression analysis, *PSYCHIATRIC clinics
Abstract

Objective: This study aims to clarify the relevant factors influencing practitioners' methods of prescribing medications for bipolar disorder, in a nation‐wide survey in Japan. Methods: The clinical records of 3130 outpatients with bipolar disorder were consecutively reviewed from 176 psychiatric outpatient clinics. Fifteen parameters, that is, five patients' including five general characteristics (sex, age, education, occupation, and social adjustment), five patients' aspects of mental functioning (onset age, comorbid mental illness, rapid‐cycling, psychopathologic severity, and followed‐up years), and five practitioners' characteristics (sex, age, specialist experience, clinic standing years, and location), were evaluated. The number of psychotropic drugs (mood stabilizers, antidepressants, antipsychotic drugs, anxiolytics, and hypnotics) was used as an index of pharmacotherapy. Converted data from each practitioner‐unit were analyzed. Results: Seven factors (patient's social adjustment, patient's psychopathology, patient's comorbid mental disorders, patient's followed‐up years, doctor's age, clinic running years, and patient's education years) were correlated to the number of psychotropic drugs. Multiple regression analysis showed that the severity of illness (poor social adjustment, and comorbid mental illness) and an intractable disease course (long followed‐up years), were significantly associated with the number of psychotropic drugs. Conclusion: Our findings indicated that patient‐related conditions affected psychotropic polypharmacy more strongly than did practitioner‐related conditions. [ABSTRACT FROM AUTHOR]

Published
2021
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126. On the multi-purpose rotary wing test-rig in NAL

Author

Shirai, Masataka, Suenaga, Hisashi, Saito, Shigeru, Baba, Shigeo, Nonaka, Osamu, Adachi, Naoto, Kato, Hidehiko, and Harada, Mitsuhiro

Subjects
high speed impulsive noise, 高速衝撃騒音, rotary wing, 翼渦干渉騒音, 風洞試験, blade vortex interaction noise, maintenance, ヘリコプタ, 回転翼, low speed wind tunnel, research facility, 研究施設, メンテナンス, wind tunnel test, 低速風洞, helicopter
Abstract

航空宇宙技術研究所の大型低速風洞では、老朽化が著しい据置式周波数変換装置を、1994年度に移動可能の装置に更新した。さらに試験効率の向上を図ることも考慮した。1995年度より1999年度にかけ、この周波数変換装置を使用する回転翼機の空力性能および騒音特性の計測を目的とした多目的高速回転翼試験装置の整備が完了した。以後1999年には基準ブレードを用いた装置の習熟運転を行い、2000年度には三菱重工業(株)との共同研究において、高速回転での衝撃騒音に関する試験を実施した。本報告では、多目的高速回転翼試験装置の概要、さらにこれまでに実施した試験についての概要を報告する。, 資料番号: AA0047428010, レポート番号: JAXA-SP-03-003

Published
2004

127. Neurosurgical Management of Recurrent Meningitis in Children

Author

Adachi, Naoto, Kashiwagi, Naoto, Yamashita, Tetsuo, and Ito, Haruhide

Subjects
Neurosurgical Repair, otorhinolaryngologic diseases, Recurrent Meningitis, 医学, Children
Abstract

We report two cases of recurrent meningitis in children. One was caused by a congenital bone defect and the other was a traumatic bone fracture on congenital fragile bones of the cribriform plate, the skull base roof of anterior ethmoidal sinuses. Recurrent ｍeningitis in two cases was completely cured by neurosurgical repair of the cribriform plate. Neurosurgical repair operations are usuful for recurrent meningitis in children resulting from congenital anatomical lesions of the skull base.

Published
1995

128. Low parathyroid hormone levels after parathyroidectomy reduce cardiovascular mortality in chronic hemodialysis patients

Author

Iwamoto, Noriyuki, primary, Sato, Nodoka, additional, Nishida, Masaya, additional, Hashimoto, Tetsuya, additional, Kobayashi, Hiroyuki, additional, Yamazaki, Satoru, additional, Okino, Koji, additional, Nishimura, Masato, additional, Takatani, Toru, additional, Okamoto, Yu, additional, Nakanouchi, Tsuneyuki, additional, Koyama, Masaki, additional, Adachi, Naoto, additional, Ninomiya, Kanji, additional, Mabuchi, Hisao, additional, and Iseki, Kunitoshi, additional

Published
2015
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137. Total parathyroidectomy improves survival of hemodialysis patients with secondary hyperparathyroidism

Author

Iwamoto, Noriyuki, primary, Sato, Nodoka, additional, Nishida, Masaya, additional, Hashimoto, Tetsuya, additional, Kobayashi, Hiroyuki, additional, Yamasaki, Satoru, additional, Ono, Toshihiko, additional, Nishimura, Masato, additional, Tokoro, Toshiko, additional, Sakoda, Chikako, additional, Murakawa, Mayuko, additional, Okino, Koji, additional, Okamoto, Yuu, additional, Imai, Ryo, additional, Adachi, Naoto, additional, Ninomiya, Kanji, additional, Mabuchi, Hisao, additional, Koyama, Masaki, additional, Nakanouchi, Tsuneyuki, additional, and Iseki, Kunitoshi, additional

Published
2011
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139. Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study

Author

Ono, Hirohisa, primary, Nishijima, Yoji, additional, Adachi, Naoto, additional, Tachibana, Shigekuni, additional, Chitoku, Shiroh, additional, Mukaihara, Shigeo, additional, Sakamoto, Masaki, additional, Kudo, Yohei, additional, Nakazawa, Jun, additional, Kaneko, Kumi, additional, and Nawashiro, Hiroshi, additional

Published
2011
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141. Authors' reply

Author

Adachi, Naoto, primary, Akanuma, Nozomi, additional, Kato, Masaaki, additional, Ito, Masumi, additional, Hara, Tsunekatsu, additional, Oana, Yasunori, additional, Matsuura, Masato, additional, Okubo, Yoshiro, additional, and Onuma, Teiichi, additional

Published
2010
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142. Successful treatment of refractory donor lymphocyte infusion‐induced immune‐mediated pancytopenia with rituximab

Author

Kato, Itaru, primary, Umeda, Katsutsugu, additional, Awaya, Tomonari, additional, Yui, Yoshihiro, additional, Niwa, Akira, additional, Fujino, Hisanori, additional, Matsubara, Hiroshi, additional, Watanabe, Ken‐Ichiro, additional, Heike, Toshio, additional, Adachi, Naoto, additional, Endo, Fumio, additional, Mizukami, Tomoyuki, additional, Nunoi, Hiroyuki, additional, Nakahata, Tatsutoshi, additional, and Adachi, Souichi, additional

Published
2009
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144. Handedness in Epilepsy Patients with Psychosis

Author

Hara, Koichiro, primary, Adachi, Naoto, additional, Matsuura, Masato, additional, Hara, Tsunekatsu, additional, Oana, Yasunori, additional, Okubo, Yoshiro, additional, Muramatsu, Reimi, additional, Kato, Masaaki, additional, and Onuma, Teiichi, additional

Published
2009
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146. Okayama Igakkai Zasshi (Journal of Okayama Medical Association)

Author

Liu, Keyue, primary, Mori, Shuji, additional, Takahashi, Hideo K., additional, Tomono, Yasuko, additional, Wake, Hidenori, additional, Kanke, Toru, additional, Sato, Yasuharu, additional, Hiraga, Norihito, additional, Adachi, Naoto, additional, Yoshino, Tadashi, additional, and Nishibori, Masahiro, additional

Published
2008
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149. Suppression of peritoneal thickening by histamine in a mouse model of peritoneal scraping.

Author

Liu, Keyue, Yorozuya, Toshihiro, Adachi, Naoto, Motoki, Atsuko, Ninomiya, Kanji, Mabuchi, Hisao, Iwamoto, Noriyuki, and Nishibori, Masahiro

Subjects
BIOGENIC amines, KIDNEY diseases, NEPHROLOGY, NEPHROTOXICOLOGY, CLINICAL trials
Abstract

Background: Inflammatory reactions play an important role in peritoneal sclerosis in patients on peritoneal dialysis. Since histamine affects inflammatory reactions and immune responses, we investigated effects of intraperitoneal administration of histamine on peritonitis induced by mechanical scraping in mice. Methods: After anesthesia, the right peritoneum was scraped 90 times over 1 min, and bilateral peritonea were observed by light microscopy after 7 days. Results: Thickness of the peritoneal membrane on the right side was 174 ± 77 µm (mean ± SD, n = 8), while that on the left side was 24 ± 19 µm. Intraperitoneal administration of histamine (0.3 or 1.0 mmol/L, 0.5 mL each) twice daily for 7 days after scraping decreased thickness of the right peritoneum to 42 and 43 % of that in saline-injected animals, respectively ( P < 0.01), although histamine (0.1 mmol/L) did not affect it. Promethazine (5 nmol, twice daily for 7 days), a histamine H receptor antagonist, abolished the amelioration caused by histamine (1.0 mmol/L). Neither ranitidine (15 nmol), a histamine H receptor antagonist, nor thioperamide (7.5 nmol), a histamine H/H receptor antagonist, affected the outcome in histamine-treated mice. Conclusion: These findings indicate that histamine H action partly prevents the development of peritoneal fibrosis caused by mechanical scraping. [ABSTRACT FROM AUTHOR]

Published
2015
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150. Dissociative experiences in epilepsy: Effects of epilepsy-related factors on pathological dissociation.

Author

Hara, Koichiro, Adachi, Naoto, Akanuma, Nozomi, Ito, Masumi, Okazaki, Mitsutoshi, Matsubara, Ryoji, Adachi, Takuya, Ishii, Ryouhei, Kanemoto, Kousuke, Matsuura, Masato, Hara, Eriko, Kato, Masaaki, and Onuma, Teiichi

Subjects
*EPILEPSY & psychology, *DISSOCIATIVE disorders, *SYMPTOMS, *JAPANESE people, *DISEASE prevalence, *REGRESSION analysis, *DISEASES
Abstract

Psychogenic nonepileptic seizures (PNESs) in patients with epilepsy can be categorized as dissociative disorders. The prevalence of PNESs in patients with epilepsy appears to be much higher than that of dissociative experiences in nonclinical subjects. In order to clarify as to whether epilepsy-related factors were associated with pathological dissociation, we conducted a controlled study with 225 patients with epilepsy and 334 nonclinically matched individuals. All participants completed the Japanese version of the Dissociative Experiences Scale (DES). There was no significant difference in the DES score (DES-S) between the group with epilepsy and the control group. The group with epilepsy showed a significantly higher DES taxon (DES-T; a subset of DES-S and an index of pathological dissociation) than the control group. Thirty-one out of the 225 patients with epilepsy (13.8%) had PNESs. Because of its strong association with the DES-S and DES-T, PNESs can be regarded as a symptom of dissociation. With multiple regression analysis, the patients with a shorter duration of epilepsy, higher seizure frequency, or shorter period in education tend to suffer from pathological dissociation. These findings demonstrate that patients with epilepsy are more prone to experiencing pathological dissociation when having certain clinical factors. [ABSTRACT FROM AUTHOR]

Published
2015
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