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415 results on '"Ahmedzai, Sam H"'

101. Integrated Care in Prostate Cancer (ICARE-P): Nonrandomized Controlled Feasibility Study of Online Holistic Needs Assessment, Linking the Patient and the Health Care Team

Author

Nanton, Veronica, primary, Appleton, Rebecca, additional, Dale, Jeremy, additional, Roscoe, Julia, additional, Hamborg, Thomas, additional, Ahmedzai, Sam H, additional, Arvanitis, Theodoros N, additional, Badger, Douglas, additional, James, Nicholas, additional, Mendelsohn, Richard, additional, Khan, Omar, additional, Parashar, Deepak, additional, and Patel, Prashant, additional

Published
2017
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102. Patient-Reported Outcome Results From the Open-Label, Randomized Phase III Myeloma X Trial Evaluating Salvage Autologous Stem-Cell Transplantation in Relapsed Multiple Myeloma.

Author

Ahmedzai, Sam H., Snowden, John A., Ashcroft, Andrew John, Cairns, David Allan, Williams, Cathy, Hockaday, Anna, Cavenagh, Jamie D., Ademokun, Debo, Tholouli, Eleni, Allotey, David, Dhanapal, Vijay, Jenner, Matthew, Yong, Kwee, Cavet, Jim, Hunter, Hannah, Bird, Jennifer M., Pratt, Guy, Parrish, Christopher, Brown, Julia M., and Morris, Treen C.M.

Published
2019
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103. Optimizing cancer pain management in resource-limited settings.

Author

CAncer Pain management in Resource-limited settings (CAPER) Working Group, Ahmedzai, Sam H., Kraychete, Durval Campos, Lee, Dae Ho, Tamura, Kazuo, Wang, Jie Jun, Bautista, Mary Jocylyn, Bouzid, Kamel, Gibson, Rachel, Gumara, Yuddi, Hassan, Azza Adel Ibrahim, Hattori, Seiji, and Keefe, Dorothy

Subjects
*CANCER pain, *PAIN management, *THERAPEUTICS, *EDUCATIONAL programs, *TEAMS in the workplace, *LITERATURE reviews
Abstract

Purpose: Adequate cancer pain management (CPM) is challenging in resource-limited settings, where current international guideline recommendations are difficult to implement owing to constraints such as inadequate availability and accessibility of opioids, limited awareness of appropriate opioid use among patients and clinicians, and lack of guidance on how to translate the best evidence into clinical practice. The multinational and multidisciplinary CAncer Pain managEment in Resource-limited settings (CAPER) Working Group proposes a two-step initiative to bridge clinical practice gaps in CPM in resource-limited settings.Methods: A thorough review of the literature, a steering committee meeting in February 2017, and post-meeting teleconference discussions contributed to the development of this initiative. As a first step, we developed practical evidence-based CPM algorithms to support healthcare providers (HCPs) in tailoring treatment according to availability of and access to resources. The second part of the initiative proposes a framework to support an effective implementation of the CPM algorithms that includes an educational program, a pilot implementation, and an advocacy plan.Results: We developed CPM algorithms for first-line use, breakthrough cancer pain, opioid rotation, and refractory cancer pain based on the National Comprehensive Cancer Network guidelines and expert consensus. Our proposed educational program emphasizes the practical elements and illustrates how HCPs can provide optimal CPM according to evidence-based guidelines despite varied resource limitations. Pilot studies are proposed to demonstrate the effectiveness of the algorithms and the educational program, as well as for providing evidence to support a draft advocacy document, to lobby policymakers to improve availability and accessibility of analgesics in resource-limited settings.Conclusions: These practical evidence-informed algorithms and the implementation framework represent the first multinational step towards achieving optimal CPM in resource-limited settings. [ABSTRACT FROM AUTHOR]

Published
2019
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109. Late effects of pelvic radiation treatment (EAGLE study).

Author

Taylor, Sophia Emily, primary, Muls, Ann, additional, Andreyev, Jervoise, additional, Green, John, additional, Farnell, Damian, additional, Smith, Lesely, additional, Ahmedzai, SAM H., additional, Pickett, Sara, additional, Ferguson, Catherine, additional, Fitzsimmons, Deborah, additional, Cambell, Susan, additional, O'Shea, Raymond, additional, Nelson, Annmarie, additional, and Staffurth, John, additional

Published
2016
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110. Patient-Reported Outcomes (PRO) in the Setting of Relapsed Myeloma: The Influence of Treatment Strategies and Genetic Variants Predict Quality of Life and Pain Experience

Author

Ahmedzai, Sam H, primary, Snowden, John A, additional, Cox, Angela, additional, Cairns, David A, additional, Williams, Cathy D, additional, Hockaday, Anna, additional, Cavenagh, Jamie, additional, Parrish, Christopher, additional, Yong, Kwee L, additional, Cavet, Jim, additional, Hunter, Hannah, additional, Bird, Jennifer, additional, Ashcroft, John, additional, Brown, Julia, additional, Morris, Curly, additional, and Cook, Gordon, additional

Published
2015
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112. Constipation in people prescribed opioids

Author

Ahmedzai, Sam H and Boland, Jason

Subjects
Analgesics, Opioid, Dioctyl Sulfosuccinic Acid, Laxatives, Humans, Supportive and Palliative Care, Constipation, Lactulose
Abstract

Constipation is reported in 52% of people with advanced malignancy. This figure rises to 87% in people who are terminally ill and taking opioids. Constipation may be the most common adverse effect of opioids. There is no reason to believe that people with chronic non-malignant disease who take opioids will be any less troubled by this adverse effect.We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of: oral laxatives, rectally applied medications, and opioid antagonists for constipation in people prescribed opioids? We searched: Medline, Embase, The Cochrane Library, and other important databases up to August 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).We found 23 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.In this systematic review we present information relating to the effectiveness and safety of the following interventions: arachis oil enemas, bisacodyl, co-danthrusate/co-danthramer, docusate, glycerol suppositories, ispaghula husk, lactulose, liquid paraffin, macrogols plus electrolyte solutions, magnesium salts, methylcellulose, opioid antagonists, phosphate enemas, senna, sodium citrate micro-enema, and sodium picosulfate.

Published
2010

117. Side effects of analgesia may significantly reduce quality of life in symptomatic multiple myeloma: a cross-sectional prevalence study

Author

Sloot, Sarah, primary, Boland, Jason, additional, Snowden, John A., additional, Ezaydi, Yousef, additional, Foster, Andrea, additional, Gethin, Alison, additional, Green, Tracy, additional, Chopra, Louise, additional, Verhagen, Stans, additional, Vissers, Kris, additional, Engels, Yvonne, additional, and Ahmedzai, Sam H., additional

Published
2014
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140. Health-related quality of life in non-small-cell lung cancer: Methodologic issues in randomized controlled trials

Author

UCL - Autre, Bottomley, Andrew, Efficace, Fabio, Thomas, Ronald, Vanvoorden, Veerle, Ahmedzai, Sam H., UCL - Autre, Bottomley, Andrew, Efficace, Fabio, Thomas, Ronald, Vanvoorden, Veerle, and Ahmedzai, Sam H.

Abstract

Purpose: Non-small-cell lung cancer (NSCLC), a leading cause of cancer-related deaths in both developed and developing countries, heavily impacts patient health-related quality of life (HRQOL). Although recent research has found many positive and significant steps in randomized controlled trials (RCTs) in which HRQOL has been used as an outcome, questions remain regarding methodologic quality and impact value of HRQOL outcome assessments in some RCTs. To date, no detailed systematic review exists of HRQOL methodology in NSCLC RCTs. Methods: A systematic review using Cochrane methodology evaluated HRQOL components in RCTs. Identified studies were evaluated independently by three reviewers on a broad set of predetermined criteria. Results: Twenty-nine published RCTs (NSCLC patient samples total, N = 8,445) with an HRQOL component were identified. Although most trials exhibited good-quality research and useful HRQOL and clinical data, the weaknesses identified in some trials include such common limitations as no clear hypothesis, lack of a clear approach to missing data and data analysis, and limited presentation of results. Conclusion: Although it is clear that HRQOL is an important end point in NSCLC RCTs because the information helps to influence treatment recommendations, the identified weaknesses in conducting HRQOL measurement in NSCLC RCTs and the reporting of results need to be addressed.

Published
2003

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