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101. Cryptosporidium Diarrhea Developing in Two Japanese Adults

Author

MASUDA, Gohta, primary, NEGISHI, Masayoshi, additional, AJISAWA, Atsushi, additional, YAMAGUCHI, Tsuyoshi, additional, TAJIMA, Tsuyoshi, additional, TAMAGAWA, Shigenori, additional, MAEDA, Yoshiharu, additional, OHTOMO, Hiroshi, additional, KIMATA, Isao, additional, UNI, Shigehiko, additional, ISEKI, Motohiro, additional, and TAKADA, Suehisa, additional

Published
1991
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102. Comparison of Clinical Efficacy of Rokitamycin (RKM) and Ofloxacin (OFLX) for the Treatment of Campylobacter Enteritis by a Double-Blind Method

Author

OBANA, Mitsuo, primary, TOMIZAWA, Isao, additional, TAKIZAWA, Yoshihiko, additional, NITTA, Yoshiro, additional, SAGARA, Hiroko, additional, SEO, Takehisa, additional, SATO, Junichi, additional, TSUNODA, Takafumi, additional, OTA, Satomi, additional, MACHII, Akira, additional, NAKAMURA, Yoshitaka, additional, KATANO, Teiko, additional, MURATA, Misako, additional, OHNISHI, Kenji, additional, YAMAGUCHI, Tsuyoshi, additional, MASUDA, Gohta, additional, NEGISHI, Masayoshi, additional, AJISAWA, Atsushi, additional, KITAHARA, Mitsuo, additional, LEE, Keiko, additional, IRIMAJIRI, Shoichiro, additional, MATSUOKA, Yasuo, additional, MATSUMOTO, Fumio, additional, IMAI, Takeo, additional, SAKURAI, Iwao, additional, TAKAHASHI, Takayuki, additional, AMANO, Fukiko, additional, MURAMOTO, Akira, additional, NAKAMURA, Chie, additional, KANOU, Hideyuki, additional, NARUSE, Jun, additional, KIM, Yong-ki, additional, INAMOTO, Yasuhiko, additional, AKAO, Mitsuru, additional, SAKAUE, Yoshihiro, additional, HOSODA, Shiro, additional, BAMBA, Tadao, additional, TATEWAKI, Kenichi, additional, YOSHIKAWA, Kunio, additional, MATSUSHITA, Iwao, additional, FUSE, Kenji, additional, SASAKI, Masaya, additional, KURISU, Kuniko, additional, NAKAGAWA, Masao, additional, KITOH, Katsuyuki, additional, KAWAJIRI, Toshio, additional, KIZU, Minoru, additional, SHIOMI, Takehiko, additional, KATAOKA, Sadao, additional, KAWAGUCHI, Yoshio, additional, FUKUMOTO, Akira, additional, TAMURA, Kazuya, additional, MURAI, Masami, additional, TANAKA, Michio, additional, KURIMURA, Osamu, additional, MATSUBARA, Yoshio, additional, SAITO, Makoto, additional, IMAGAWA, Yatsuka, additional, NAKAYA, Rintaro, additional, HORIUCHI, Sankichi, additional, and INAGAKI, Yoshio, additional

Published
1991
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104. Comparative Clinical Trial of HBK and Amikacin (AMK) in the Treatment of Respiratory Infections

Author

HARA, Kohei, primary, SAITO, Atsushi, additional, YAMAGUCHI, Keizo, additional, SHIGENO, Yoshiteru, additional, TAIRA, Kazushige, additional, ODA, Toshiro, additional, HAYASHI, Toshiaki, additional, TOMITA, Hiroshi, additional, MASUYAMA, Yasuharu, additional, SAITO, Akira, additional, TOMIZAWA, Masumi, additional, NAKAYAMA, Ichiro, additional, ABE, Morikuni, additional, MATSUHASHI, Shosei, additional, ISHIKAWA, Kiyofumi, additional, UJIIE, Akira, additional, NAKABAYASHI, Takehito, additional, KOROKU, Tetsuji, additional, HIRAGA, Yohmei, additional, KIKUCHI, Kohki, additional, YAMAMOTO, Asako, additional, TAKEBE, Kazuo, additional, OKAMOTO, Katsuhiro, additional, SAGARA, Morio, additional, TAMURA, Toyokazu, additional, ENDO, Katsumi, additional, IRIE, Tatsuro, additional, UEHARA, Osamu, additional, TAMURA, Masao, additional, ITO, Takashi, additional, OBARA, Kazuo, additional, MIYAMOTO, Shinya, additional, KANAZAWA, Tomohiro, additional, TAKAHASHI, Hiroshi, additional, KUROKAWA, Hirokazu, additional, YASUI, Shoji, additional, TAKAHASHI, Keiji, additional, SATO, Shinobu, additional, IKEDA, Hideki, additional, NAKAMURA, Hidenori, additional, YASUMURA, Seiji, additional, IGARASHI, Kohichi, additional, HOSHI, Hikaru, additional, YAKUWA, Sunao, additional, TAKISHIMA, Tamotsu, additional, IDA, Shiroh, additional, KONNO, Kiyoshi, additional, OIZUMI, Kotaro, additional, AONUMA, Seiichi, additional, WATANABE, Akira, additional, NAGAI, Kosaku, additional, SATO, Kazuo, additional, HAYASHI, Izumi, additional, KATSU, Masataka, additional, KAWAI, Mieko, additional, OGIWARA, Koji, additional, KAWAI, Takeshi, additional, AJISAWA, Atsushi, additional, SATO, Shigeaki, additional, ISHIKAWA, Kazuhito, additional, MIYAHARA, Tadashi, additional, IKEMOTO, Hideo, additional, WATANABE, Kazuyoshi, additional, ISONUMA, Hiroshi, additional, KOBAYASHI, Hiroyuki, additional, KAWAI, Shin, additional, YOSHIDA, Masahiko, additional, KUNII, Otohiko, additional, MASHIMO, Keimei, additional, YAMANE, Yoshiji, additional, UKAI, Tetsuro, additional, KOYAMA, Masaru, additional, IIJIMA, Fukuo, additional, KABE, Junzaburo, additional, ISHIBASHI, Hiroyoshi, additional, UNO, Yuko, additional, TANIMOTO, Hiroichi, additional, CHONABAYASHI, Naohiko, additional, NAKAMORI, Yoshitaka, additional, YOSHIMURA, Kunihiko, additional, NAKATANI, Tatsuo, additional, NAKATA, Koichiro, additional, MASUDA, Gohta, additional, NEGISHI, Masayoshi, additional, YOUNG, Chenden, additional, HIGASHI, Fuyuhiko, additional, FUNATSU, Yuzo, additional, FUJIMORI, Ippei, additional, KOBAYASHI, Yoshio, additional, OKUBO, Takao, additional, ITO, Akira, additional, SANO, Fumihiko, additional, MATSUZAKI, Michio, additional, ASADA, Yuko, additional, ODAGIRI, Shigeki, additional, SUZUKI, Kaneo, additional, MUROHASHI, Kou, additional, FUKUDA, Tsutomu, additional, YOSHIIKE, Yasuhiro, additional, MATSUMURA, Masanori, additional, KIUCHI, Mitsuyo, additional, MATSUMOTO, Fumio, additional, FUKAYA, Kazufuto, additional, TAKIGAMI, Tadashi, additional, SHODA, Masataka, additional, ARAKAWA, Masaaki, additional, WADA, Kohichi, additional, SEKINE, Osamu, additional, AOKI, Nobuki, additional, OYAMA, Kaoru, additional, NAKAMURA, Shinobu, additional, NAKAMURA, Takeshi, additional, YAMAMOTO, Toshiyuki, additional, SUZUKI, Kanzo, additional, ADACHI, Akira, additional, KUZE, Fumiyuki, additional, NAKANISHI, Michiyasu, additional, KURASAWA, Takuya, additional, KUBO, Yoshiro, additional, NISHIYAMA, Hideki, additional, IKEDA, Nobuaki, additional, INABA, Norio, additional, KAGIOKA, Akira, additional, MIKI, Fumio, additional, IKUNO, Yoshiyasu, additional, INOUE, Eiji, additional, MURATA, Akihito, additional, TANIZAWA, Shin-ichi, additional, SAKAMOTO, Kazuo, additional, TAKAMATSU, Kenji, additional, SOEJIMA, Rinzo, additional, NIKI, Yoshihito, additional, HINO, Jiro, additional, NAKAGAWA, Yoshihisa, additional, NISHIMOTO, Yukio, additional, YAMAKIDO, Michio, additional, KAMITSUNA, Akimitsu, additional, HASEGAWA, Kenji, additional, KURIMURA, Osamu, additional, SASAKI, Hideo, additional, FUKUHARA, Hirofumi, additional, TAMURA, Masakazu, additional, TSUBURA, Eiro, additional, FUKUYAMA, Koichi, additional, MORIMOTO, Tadaaki, additional, SAWAE, Yoshiro, additional, NAGANO, Hitoshi, additional, YOKOTA, Takeo, additional, YOKOTA, Kinji, additional, SHINODA, Atsushi, additional, ISHIBASHI, Tsuneo, additional, TAKAMOTO, Masahiro, additional, HARADA, Yasuko, additional, KITAHARA, Yoshinari, additional, KAJI, Masaro, additional, ICHIKAWA, Yoichiro, additional, NASU, Masaru, additional, GOTO, Jun, additional, GOTO, Yoichiro, additional, YAMAZAKI, Hitoshi, additional, TASHIRO, Takayoshi, additional, MATSUMOTO, Keizo, additional, OHISHI, Kazunori, additional, IZUMIKAWA, Kinichi, additional, KOTEDA, Tsunetoshi, additional, NAKAJIMA, Manabu, additional, KOMATSU, Kohei, additional, NAKATA, Masaya, additional, SENJU, Reiko, additional, ANDO, Masayuki, additional, SUGA, Moritaka, additional, NIIBORI, Toshifumi, additional, NAKAGAWA, Toshiyuki, additional, YOSHIDA, Kazuko, additional, KOBARI, Kazumine, additional, NAKATOMI, Masao, additional, and TANAKA, Tsuneo, additional

Published
1987
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105. Comparative Study of MK-0787/MK-0791 and Piperacillin in Respiratory Tract Infections

Author

SOEJIMA, Rinzo, primary, MATSUSHIMA, Toshiharu, additional, KAWANE, Hiroshi, additional, NIKI, Yoshihito, additional, KAWANISHI, Masayoshi, additional, NAKAHAMA, Chikara, additional, HINO, Jiro, additional, SAITO, Akira, additional, NAKAYAMA, Ichiro, additional, TOMIZAWA, Masumi, additional, TAKEBE, Kazuo, additional, KUMASAKA, Yoshihiro, additional, NAKAMURA, Teruo, additional, YOSHIDA, Tsukasa, additional, YOSHIZAWA, Masayuki, additional, MIZUKOSHI, Kazuo, additional, IDA, Shiroh, additional, TAKISHIMA, Tamotus, additional, AONUMA, Seiichi, additional, WATANABE, Akira, additional, OIZUMI, Kotaro, additional, KONNO, Kiyoshi, additional, ITOH, Tsugushi, additional, HAYASHI, Izumi, additional, ARAKAWA, Masaaki, additional, WADA, Koichi, additional, YOSHIDA, Ryohji, additional, KONDOH, Ariyoshi, additional, HOSHINO, Akio, additional, HIRONO, Koichi, additional, NOZAWA, Yukio, additional, TERADA, Haruo, additional, ASANO, Ryozoh, additional, NARITA, Masanori, additional, YAMASAKU, Fusanosuke, additional, SUZUKI, Yasutoshi, additional, SEKINE, Osamu, additional, AOKI, Nobuki, additional, HASEGAWA, Shizuo, additional, YOSHIZAWA, Yasuyuki, additional, KAMEYAMA, Yoshiaki, additional, UCHIDA, Yoshiyuki, additional, KATSU, Masataka, additional, FUKUI, Toshio, additional, YAMAGATA, Hajime, additional, KAWAI, Mieko, additional, SAITO, Reiko, additional, SATO, Minoru, additional, YOKOSE, Takashi, additional, KAWAI, Takeshi, additional, ONAKA, Akio, additional, AJISAWA, Atsushi, additional, KAMO, Takeshi, additional, HIGASHI, Fuyuhiko, additional, NAKAMURA, Masahiko, additional, ARIKAWA, Kazumi, additional, YAMAGAMI, Keiichi, additional, TAKANO, Makoto, additional, NUMASA, Sozo, additional, FUNATSU, Yuzo, additional, KITAHARA, Mitsuo, additional, TAKAHASHI, Yukinori, additional, UEDA, Yasushi, additional, SAITO, Atsushi, additional, KAJI, Masanobu, additional, MIYAHARA, Tadashi, additional, TANIMOTO, Hiroichi, additional, CHONABAYASHI, Naohiko, additional, YOSHIMURA, Kunihiko, additional, NAKATANI, Tatsuo, additional, NAKAMORI, Yoshitaka, additional, NAKATA, Koichiro, additional, KABE, Junzaburo, additional, ISHIBASHI, Hiroyoshi, additional, KUDOH, Koichiro, additional, SATOH, Toshinobu, additional, DOI, Makoto, additional, MASHIMO, Keimei, additional, UKAI, Tetsuro, additional, NAKAGAWA, Keiichi, additional, WATANABE, Kentaro, additional, KOYAMA, Masaru, additional, IIJIMA, Fukuo, additional, TANAKA, Motokazu, additional, MORINARI, Hajime, additional, OKUBO, Syuichi, additional, FUJIEDA, Kazuo, additional, ITOH, Toshio, additional, SHIMIZU, Kihachiro, additional, KUMADA, Teppei, additional, OOI, Satoshi, additional, TOTSUKA, Kyoichi, additional, IKEMOTO, Hideo, additional, WATANABE, Kazuyoshi, additional, SHIMADA, Kaoru, additional, INAMATSU, Takashi, additional, URAYAMA, Kyoko, additional, KOBAYASHI, Hiroyuki, additional, OSHITANI, Hiroshi, additional, YOSHIDA, Masahiko, additional, FUJIMORI, Ippei, additional, KOBAYASHI, Yoshio, additional, FUKAYA, Kazufuto, additional, OKUBO, Takao, additional, ITOH, Akira, additional, ODAGIRI, Shigeki, additional, HASEGAWA, Hideyuki, additional, YAMABE, Kaitaro, additional, KURIHARA, Makio, additional, TAKAHASHI, Kenichi, additional, TAKAHASHI, Hideo, additional, MIURA, Tomiji, additional, MATSUMOTO, Fumio, additional, TAKEUCHI, Toshihiko, additional, KATO, Masahito, additional, HANAKI, Hidekazu, additional, NANJO, Kunio, additional, YAMAMOTO, Toshiyuki, additional, SUZUKI, Kanzo, additional, YAMAMOTO, Kazuhide, additional, YAMASHITA, Naohiro, additional, HOSHINO, Kiyoshi, additional, SUGIYAMA, Eiji, additional, MIZUSHIMA, Yutaka, additional, YANO, Saburo, additional, OYAMA, Kaoru, additional, NISHIYAMA, Hideki, additional, NAKAI, Hitoshi, additional, OIDA, Kazukiyo, additional, IKEDA, Nobuaki, additional, TSUJINO, Hiroyuki, additional, HASE, Mitsuo, additional, MATSUYAMA, Eiichi, additional, KUZE, Fumiyuki, additional, OKAMOTO, Yuruko, additional, YONEZU, Seibun, additional, IIDA, Yube, additional, UEDA, Yoshihiro, additional, OKUBO, Hiroshi, additional, MIKI, Fumio, additional, MURATA, Akihito, additional, KURIMURA, Osamu, additional, SASAKI, Hideo, additional, FUKUHARA, Hirofumi, additional, YAMAKIDO, Michio, additional, KUWABARA, Masao, additional, NOMURA, Toshiya, additional, MITSUYAMA, Toyofumi, additional, ARITA, Horoyuki, additional, KAMITSUNA, Akimitsu, additional, SAWAE, Yoshiro, additional, OKADA, Kaoru, additional, KUMAGAI, Yukio, additional, NIHO, Yoshiyuki, additional, SHIGEMATSU, Nobuaki, additional, KOHASHI, Osamu, additional, NINOMIYA, Kiyoshi, additional, NAGANO, Hitoshi, additional, HIROSE, Takahito, additional, SHINODA, Atsusi, additional, ISHIBASHI, Tsuneo, additional, TAKAMOTO, Masahiro, additional, HARA, Kohei, additional, YAMAGUCHI, Keizo, additional, SUZUYAMA, Yoji, additional, KOHNO, Shigeru, additional, SHIGENO, Yoshiteru, additional, ODA, Toshiro, additional, OHTA, Hirosuke, additional, MIYAZAKI, Takashige, additional, OYE, Toshiyuki, additional, MATSUMOTO, Keizo, additional, RIKITOMI, Naoto, additional, NAGATAKE, Tsuyoshi, additional, SISIDO, Harumi, additional, UZUKA, Yoshio, additional, ITOGA, Takashi, additional, NASU, Masaru, additional, GOTO, Jun, additional, GOTO, Yoichiro, additional, TASHIRO, Takayoshi, additional, KURODA, Yoshinobu, additional, ARAKI, Shukuro, additional, ANDO, Masayuki, additional, SUGIMOTO, Mineharu, additional, SUGA, Moritaka, additional, KOBARI, Kazumine, additional, NAKATOMI, Masao, additional, KINJO, Yutoku, additional, IRABU, Yuei, additional, HIGA, Minoru, additional, and NAKAMURA, Hiroaki, additional

Published
1986
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106. Comparative Study of the Effectiveness of Lenampicillin and Bacampicillin on Bacterial Pneumonia by Double Blind Method

Author

MIKI, Fumio, primary, IKUNO, Yosiyasu, additional, INOUE, Eiji, additional, YOSIYAMA, Minoru, additional, MURATA, Tetsuto, additional, TANIZAWA, Shin-ichi, additional, SAKAMOTO, Kazuo, additional, SAKAI, Hirozumi, additional, SAITO, Akira, additional, TOMIZAWA, Masumi, additional, NAKAYAMA, Ichiro, additional, YAJIMA, Osamu, additional, UJIIE, Akira, additional, TAKEBE, Kazuo, additional, MASUDA, Mitsuo, additional, MURAKAMI, Seiichi, additional, OSONOI, Takeshi, additional, MAEDA, Toshikazu, additional, SASAKI, Kazuo, additional, KONNO, Kiyoshi, additional, OIZUMI, Kotaro, additional, AONUMA, Seiichi, additional, NAGAI, Kosaku, additional, YOSHIDA, Tsukasa, additional, CHIBA, Syuji, additional, SATO, Kazuo, additional, HASUIKE, Teruo, additional, TAMAKI, Shigeru, additional, HAYASHI, Izumi, additional, MIYAHARA, Tadashi, additional, SAITO, Atsushi, additional, IKEMOTO, Hideo, additional, WATANABE, Kazuyoshi, additional, WATANABE, Kentaro, additional, KOYAMA, Masaru, additional, IIJIMA, Fukuo, additional, SHIMADA, Kaoru, additional, INAMATSU, Takashi, additional, URAYAMA, Kyoko, additional, KATSU, Masataka, additional, OGIHARA, Hiroharu, additional, HIGASHI, Fuyuhiko, additional, SEKIMOTO, Toshio, additional, KAWAI, Takeshi, additional, ONAKA, Akio, additional, AJISAWA, Atsushi, additional, KATAYAMA, Tetsuji, additional, MIYAJI, Hayato, additional, MURAYAMA, Yumiko, additional, MASHIMO, Keimei, additional, ITO, Chizuru, additional, TANIMOTO, Hiroichi, additional, YOSHIMURA, Kunihiko, additional, CHONABAYASI, Naohiko, additional, NAKATANI, Tatsuo, additional, KOBAYASHI, Hiroyuki, additional, OSHITANI, Hiroshi, additional, KABE, Junzaburo, additional, ISHIBASHI, Hiroyoshi, additional, SANO, Yasuyuki, additional, FUJIMORI, Ippei, additional, KOBAYASHI, Yoshio, additional, NAKAMURA, Yasushi, additional, OKUBO, Takao, additional, ITO, Akira, additional, MATSUMOTO, Fumio, additional, FUKAYA, Kazufuto, additional, ODAGIRI, Shigeki, additional, IKEDA, Hirotada, additional, NOSE, Keinosuke, additional, MUROHASHI, Kou, additional, WATANABE, Shin-ichiro, additional, TAKEDA, Hajimu, additional, WADA, Koichi, additional, KABASAWA, Tomoko, additional, YAMASAKU, Fusanosuke, additional, SUZUKI, Yasutoshi, additional, SEKINE, Osamu, additional, AOKI, Nobuki, additional, OYAMA, Kaoru, additional, TAKEUCHI, Toshihiko, additional, KATO, Masahito, additional, HANAKI, Hidekazu, additional, USAMI, Ikuji, additional, NAGASAKA, Hirohiko, additional, YAMADA, Yasuo, additional, ITO, Tsuyoshi, additional, TERAO, Naohiko, additional, KUROKI, Hideaki, additional, YAMAMOTO, Toshiyuki, additional, MAEKAWA, Nobuo, additional, NAKANISHI, Michiyasu, additional, NISHIYAMA, Hideki, additional, YAMAMOTO, Takayoshi, additional, SHIBATA, Yasutaku, additional, TSUJINO, Hiroyuki, additional, MIKAMI, Riichiro, additional, SAWAKI, Masayoshi, additional, OKAMOTO, Yuruko, additional, IIDA, Yube, additional, MAEHARA, Keigo, additional, OKUBO, Hiroshi, additional, UEDA, Yoshihiro, additional, TAKAMATSU, Kenji, additional, SOEJIMA, Rinzo, additional, NIKI, Yoshihito, additional, NISHIMOTO, Yukio, additional, KAMITSUNA, Akimitsu, additional, NAKANISHI, Shigekiyo, additional, YAMAKIDO, Michio, additional, HASEGAWA, Kenji, additional, NOUMI, Kazumasa, additional, KURIMURA, Osamu, additional, MASUDA, Tadashi, additional, TSUBURA, Eiro, additional, TAMURA, Masakazu, additional, NAKAYAMA, Tadashi, additional, SENOO, Etsuo, additional, TANI, Kenji, additional, HIGUCHI, Yuji, additional, KAMEI, Toshihiko, additional, SAWAE, Yoshiro, additional, OKADA, Kaoru, additional, HARA, Kohei, additional, YAMAGUCHI, Keizo, additional, SUZUYAMA, Yoji, additional, SHIGENO, Yoshiteru, additional, OKUNO, Kazuhiro, additional, OKA, Rokushi, additional, MATSUMOTO, Keizo, additional, MAGATAKE, Tsuyoshi, additional, RIKITOMI, Naoto, additional, HAYASHI, Masato, additional, HOSOYA, Ken-ichi, additional, ZAYASU, Kiyoshi, additional, ARAKI, Yoshiro, additional, ANDO, Masayuki, additional, SUGIMOTO, Mineharu, additional, NAOE, Hiroaki, additional, FUKUDA, Yasutsugu, additional, TOKUNAGA, Katsumasa, additional, SHIMA, Kiyoshi, additional, HIGUCHI, Sadanobu, additional, ITOGA, Takashi, additional, NASU, Masaru, additional, GOTO, Jun, additional, GOTO, Yoichiro, additional, TASHIRO, Takayoshi, additional, KOBARI, Kazumine, additional, and NAKATOMI, Masao, additional

Published
1985
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107. [Current Topics of Cancer and HIV].

Author

Tanaka M and Ajisawa A

Subjects
Humans, Incidence, Smoking, HIV Infections, Neoplasms
Abstract

Antiretroviral therapy(ART)has been associated with reduced AIDS- and non-AIDS-related morbidity and mortality in people living with HIV/AIDS(PLWH). Nevertheless, the incidence of many comorbid conditions remains higher in PLWH than in the general population, including AIDS-defining malignancies(ADM)as well as several non-AIDS-defining malignancies (NADM). It's important to prevent ADM/NADM, like periodic health checkup for early diagnosis, to quit smoking, and cooperation with cancer and HIV specialists.

Published
2020

108. [Ocular Syphilis Complicated with HIV Infection: A Report of 3 Cases].

Author

Fukushima K, Yanagisawa N, Sasaki S, Sekiya R, Sekiya N, Suganuma A, Ajisawa A, and Imamura A

Subjects
Adult, Eye Infections, Bacterial diagnosis, Eye Infections, Bacterial pathology, HIV Infections complications, HIV Infections diagnosis, Humans, Male, Syphilis complications, Syphilis diagnosis, Syphilis pathology, Treatment Outcome, Anti-Bacterial Agents therapeutic use, Eye Infections, Bacterial drug therapy, HIV Infections drug therapy, Penicillins therapeutic use, Syphilis drug therapy
Abstract

We present 3 cases of ocular syphilis in patients who had been newly diagnosed as having HIV. All the patients had only complained of ophthalmologic symptoms at the time of their initial visit. Treatment with penicillin was successful, resulting in no significant sequelae. Ocular syphilis may lead to reduced visual acuity or even blindness if left untreated. However, the diagnosis may be challenging, since patients may lack symptoms that are commonly observed in cases with primary and secondary syphilis. Considering the recent increase in the number of syphilis patients, clinicians should be aware of ocular syphilis and should have a high index of suspicion for syphilis in any patient at risk so as to ensure a prompt diagnosis.

Published
2016
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109. [Murine typhus in a Japanese traveler returning from Indonesia: a case report].

Author

Kato H, Yanagisawa N, Sekiya N, Suganuma A, Imamura A, and Ajisawa A

Subjects
Humans, Indonesia, Male, Young Adult, Travel, Typhus, Endemic Flea-Borne diagnosis
Abstract

We report herein on a 20-year-old Japanese man who was referred to our hospital for fever and diarrhea after returning from Indonesia. On admission, his blood test was essentially normal, besides a slight elevation in inflammatory markers. After excluding malaria and dengue fever, empiric use of ceftriaxone was initiated for suspected enteric fever, which was unsuccessful. However, drastic clinical improvement was observed after initiation of minocycline. The polymerase chain reaction test for Rickettsia typhi was positive from serum samples on admission, confirming the diagnosis of murine typhus. Although rarely seen in Japan, clinicians should be aware of this disease when examining patients with fever coming back from murine typhus endemic areas.

Published
2014
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110. [Immunodeficiency related malignant lymphoma: diagnosis and therapy of AIDS-related lymphoma].

Author

Ajisawa A

Subjects
Humans, Lymphoma, AIDS-Related diagnosis, Lymphoma, AIDS-Related drug therapy
Abstract

AIDS-related lymphoma (ARL) remains a significant burden for specialists in HIV/AIDS medicine. Pathological findings of ARL are often non-typical in various histological types. Diagnosis of correct histological type of ARL by the skilled pathologist is essential. Therapy of patients with ARL is the challenge of integrating treatment appropriate for the stage and histological subset of non-Hodgkin lymphoma. In addition to chemotherapy, essential components of an optimal ARL treatment strategy include antiretroviral therapy and prophylaxis for opportunistic infections.

Published
2014

111. [Necrotizing fasciitis after a cat bite: a case report].

Author

Hosoda T, Yanagisawa N, Morioka H, Suganuma A, Imamura A, and Ajisawa A

Subjects
Animals, Bacteroides isolation & purification, Bites and Stings diagnosis, Bites and Stings therapy, Fasciitis, Necrotizing diagnosis, Fasciitis, Necrotizing microbiology, Female, Humans, Middle Aged, Pasteurella isolation & purification, Anti-Bacterial Agents therapeutic use, Cats, Debridement methods, Fasciitis, Necrotizing drug therapy
Abstract

We report on a previously healthy 56-year-old woman who was referred to our hospital with fever and progressive left foot pain. She had been bitten by a cat 7 days previously, and cephalosporins had been prescribed for treatment. However, her clinical symptoms deteriorated, and physical examination on admission was compatible with necrotizing fasciitis. Treatment with ampicillin-sulbactam and clindamycin was initiated. In addition, immediate surgical debridement was performed, resulting in therapeutic success. Culture of the necrotizing tissue grew multiple organisms, including Pasteurella multocida and Bacteroides caccae. Administration of appropriate antibiotics after a cat bite is essential for the prevention of potentially fatal complications.

Published
2013
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112. [Immunodeficiency related malignant lymphoma].

Author

Ajisawa A

Subjects
Antiretroviral Therapy, Highly Active, Brain Neoplasms etiology, Humans, Lymphoma, Large B-Cell, Diffuse etiology, Lymphoma, Non-Hodgkin etiology, Lymphoma, Primary Effusion etiology, Lymphoma, AIDS-Related diagnosis, Lymphoma, AIDS-Related drug therapy
Published
2012

113. [Treatment strategy for HIV/AIDS including guidelines].

Author

Ajisawa A

Subjects
Acquired Immunodeficiency Syndrome drug therapy, Humans, Practice Guidelines as Topic, Antiretroviral Therapy, Highly Active methods, HIV Infections drug therapy
Abstract

The introduction of highly active antiretroviral therapy (HAART) dramatically reduced HIV-associated morbidity and mortality. However HIV-associated metabolic syndrome, characterized by dyslipidemia and fat redistribution, is frequently observed in patients with HIV. Also an increase in the incidence of chronic kidney diseases(CKD) and non-AIDS indicated malignancies has been reported. When to start and what to start of HAART is important to improve and preserve immune function. A potential secondary benefit is protecting the complications after long-term therapy.

Published
2010

115. [Clinical features of lung cancer HIV-infected patients].

Author

Kato T, Ieki R, Saito E, Ot T, Yuasa K, Iguchi M, Okamura T, Shibuya M, and Ajisawa A

Subjects
Adult, Anti-HIV Agents therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, HIV Infections drug therapy, Homosexuality, Humans, Lung Neoplasms drug therapy, Male, Middle Aged, Smoking, HIV Infections complications, Lung Neoplasms etiology
Abstract

Since HIV infection and opportunistic infections began to be treated by highly active antiretroviral therapy (HAART), the incidence of cancers, especially lung cancer increased. The clinical course of lung cancer in HIV infected patients is more aggressive, and little is known about its features or management. We retrospectively evaluated 6 cases of lung cancer with HIV infected patients in Tokyo Metropolitan Komagome Hospital. All patients were male and current smokers. Adenocarcinoma, squamous cell carcinoma and small cell carcinoma were observed in 3, 2 and 1, respectively. There were 2 cases each of clinical Stage I, IIIB, and IV were each 2 cases. The range of the CD4 cell count was 52-432/microL. HIV infection was confirmed concurrently with the diagnosis of lung cancer or complications in 5 of 6 patients. Some cases treated for both lung cancer and HIV, had a relatively good clinical course. We suggest that cancer treatment concurrently with HAART may be useful for similar cases. Further experience and study are necessary.

Published
2007

116. [A case of disseminated candidiasis as an initial presentation of AIDS].

Author

Yanagisawa N, Suganuma A, Takeshita N, Imamura A, Ajisawa A, Negishi M, Suzuki T, and Honma M

Subjects
Adult, Candida albicans isolation & purification, Candidiasis, Cutaneous etiology, Candidiasis, Cutaneous pathology, Female, Humans, Acquired Immunodeficiency Syndrome complications, Candidiasis etiology, Candidiasis pathology
Abstract

A 44-year-old woman referred for skin eruptions and an altered mental status was confirmed to have HIV infection on Western Blot analysis. Her CD4+ T cell count was 15/microl. On admission, she appeared quite ill with respiratory distress. Chest X-ray showed bilateral patchy infiltration and pleural effusions. She was treated with cefotaxime, pentamidine, and antituberculosis drugs, but her condition worsened and dopamine was initiated. Intensive treatment failed, and she died the following day. An autopsy showed purplish papules on her face and trunk and multiple white nodules in her liver, spleen and lungs. Culture was positive for Candida Albicans, yielding a diagnosis and of disseminated candidiasis. It is rare for HIV patients to be diagnosed with disseminated candidiasis, since the pathogenesis usually requires disruption of the mucosal barrier. The defense mechanism against disseminated candidiasis is mainly neutrophils and macrophages, and its dysfunction is not a primary characteristic of HIV infection. To the best of our knowledge, this is the first report in Japan of a HIV patient to have disseminated candidiasis.

Published
2007
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117. [Voriconazole as an effective therapy against pulmonary aspergillosis in a man with immunodeficiency virus-infection: a case report].

Author

Yanagisawa N, Takeshita N, Suganuma A, Imamura A, Ajisawa A, Negishi M, Suzuki T, and Honma M

Subjects
Humans, Male, Middle Aged, Voriconazole, Antifungal Agents therapeutic use, Aspergillosis drug therapy, HIV Infections complications, Lung Diseases, Fungal drug therapy, Pyrimidines therapeutic use, Triazoles therapeutic use
Abstract

A 45-year-old homosexual man with pneumocystis pneumonia and esophageal candidiasis tested positive in ELISA and Western blot analysis for HIV-1. His CD4+ T cell count was 43/microL and his HIV-RNA load was 250,000 copies/mL. He was treated with Trimetoprim-Sulfamethoxazole, Prednisolone and Fluconazole. Valganciclovir was added to treat CMV retinitis. During the clinical course, 21 days after admission, the patient presented with a temperature of 39 degrees C and blood analysis showed neutropenia. Cefepime and G-CSF were initiated, but new consolidation was observed in the upper left lobe in chest radiography. He underwent bronchoscopy and lavage culture was positive for Aspergillus fumigatus. Serum testing of galactomannan was also positive and pulmonary aspergillosis was diagnosed. The patient was initially treated with Micafungin but switched to Voriconazole when clinical symptoms worsened. An eventual clinical response was observed and pulmonary aspergillosis was controlled. Unfortunately, he died of sepsis due to MRSA 2 months later. Pulmonary aspergillosis is a devastating complication with poor prognosis in patients with HIV infection. Amphotericin-B has been the mainstay of pulmonary aspergillosis treatment, but reports indicate mortality exceeding 80%. Use of Voriconazole, a relatively new antifungal agent, may lower mortality with fewer adverse effects than conventional antifungal therapy.

Published
2007
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119. [Cyclosporiasis: four case reports with a review of the literature].

Author

Masuda G, Ajisawa A, Imamura A, Negishi M, and Iseki M

Subjects
Adult, Cyclosporiasis diagnosis, Cyclosporiasis drug therapy, HIV Seropositivity immunology, HIV-1 immunology, Humans, Male, Middle Aged, Prospective Studies, Anti-Infective Agents therapeutic use, Cyclospora, Cyclosporiasis transmission, Travel, Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use
Abstract

Four patients infected with Cyclospora cayetanensis who sought medical care at the Tokyo Metropolitan Komagome Hospital are herein presented. All were Japanese males, and their ages ranged from 22 to 50 years of age. One patient, who was HIV-positive with a CD4+ lymphocyte count of 141/microliter, demonstrated no AIDS-defining illness. This patient acquired HIV in some Southeast Asian country/countries through heterosexual contact. This patient presented with watery diarrhea with a frequency of up to 18 times a day for more than two months. The other three cases were not considered to be debilitated hosts. Diarrhea occurring from one to ten times a day continued for 6 to 26 days in all of these three patients. The presumed origin of the infection was considered to be Southeast Asian countries and the season of onset of diarrhea was March to July in all four cases. Treatment with a sulfamethoxazole/trimethoprim compound was performed for both the HIV-infected patient and the other non-debilitated patient. Both symptomatic and parasitologic improvements were quickly observed in these patients. A prospective study was performed using fecal specimens from the diarrheal patients to identify the presence of C. cayetanensis during the period from 1996 to 2001. Protozoa-positive specimens were found in 3 of 410 (0.7%) specimens from patients who had traveled overseas, is one of 148 (0.7%) for HIV-infected (the C. cayetanensis-positive patient also acquired the protozoa in Southeast Asia), and in none of 513 (0%) patients who developed diarrhea in Japan. In summary, C. cayetanensis infection is rare in Japan and most patients infected with this pathogen tend to be overseas travelers and HIV-infected individuals at present.

Published
2002
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120. [Salvage therapy in HIV disease].

Author

Ajisawa A

Subjects
Anti-HIV Agents administration & dosage, Antiretroviral Therapy, Highly Active, Drug Therapy, Combination, HIV Protease Inhibitors administration & dosage, Humans, Japan, Patient Compliance, Referral and Consultation, Reverse Transcriptase Inhibitors administration & dosage, Treatment Failure, HIV Infections drug therapy, Salvage Therapy
Abstract

Highly active antiretroviral treatment(HAART) is very effective for Japanese Human immunodeficiency virus(HIV) patients in the morbidity and mortality. But the need for salvage therapy is related to the imperfection of current antiretroviral therapy. HIV-RNA load will be detectable in approximately 40% of non-naive HIV patients who are taking triple therapy after 1 year of follow-up. Treatment failure may be related to poor adherence, resistant virus and poor pharmacological bioavailability. This article aims at describing the strategic thoughts in rapid development of pathophysiological as well as clinical and drug-related knowledge. Patient commitment, physician knowledge and an informed supportive environment are important to success in salvage therapy.

Published
2002

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