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The Simons Observatory (SO) is a ground-based cosmic microwave background(CMB) experiment sited on Cerro Toco in the Atacama Desert in Chile thatpromises to provide breakthrough discoveries in fundamental physics, cosmology,and astrophysics. Supported by the Simons Foundation, the Heising-SimonsFoundation, and with contributions from collaborating institutions, SO will seefirst light in 2021 and start a five year survey in 2022. SO has 287collaborators from 12 countries and 53 institutions, including 85 students and90 postdocs. The SO experiment in its currently funded form ('SO-Nominal') consists ofthree 0.4 m Small Aperture Telescopes (SATs) and one 6 m Large ApertureTelescope (LAT). Optimized for minimizing systematic errors in polarizationmeasurements at large angular scales, the SATs will perform a deep,degree-scale survey of 10% of the sky to search for the signature of primordialgravitational waves. The LAT will survey 40% of the sky with arc-minuteresolution. These observations will measure (or limit) the sum of neutrinomasses, search for light relics, measure the early behavior of Dark Energy, andrefine our understanding of the intergalactic medium, clusters and the role offeedback in galaxy formation. With up to ten times the sensitivity and five times the angular resolution ofthe Planck satellite, and roughly an order of magnitude increase in mappingspeed over currently operating ("Stage 3") experiments, SO will measure the CMBtemperature and polarization fluctuations to exquisite precision in sixfrequency bands from 27 to 280 GHz. SO will rapidly advance CMB science whileinforming the design of future observatories such as CMB-S4.

The Simons Observatory (SO) is a new cosmic microwave background experiment being built on Cerro Toco in Chile, due to begin observations in the early 2020s. We describe the scientific goals of the experiment, motivate the design, and forecast its performance. SO will measure the temperature and polarization anisotropy of the cosmic microwave background in six frequency bands centered at: 27, 39, 93, 145, 225 and 280 GHz. The initial configuration of SO will have three small-aperture 0.5-m telescopes and one large-aperture 6-m telescope, with a total of 60,000 cryogenic bolometers. Our key science goals are to characterize the primordial perturbations, measure the number of relativistic species and the mass of neutrinos, test for deviations from a cosmological constant, improve our understanding of galaxy evolution, and constrain the duration of reionization. The small aperture telescopes will target the largest angular scales observable from Chile, mapping 10% of the sky to a white noise level of 2 μK-arcmin in combined 93 and 145 GHz bands, to measure the primordial tensor-to-scalar ratio, r, at a target level of σ(r)=0.003. The large aperture telescope will map 40% of the sky at arcminute angular resolution to an expected white noise level of 6 μK-arcmin in combined 93 and 145 GHz bands, overlapping with the majority of the Large Synoptic Survey Telescope sky region and partially with the Dark Energy Spectroscopic Instrument. With up to an order of magnitude lower polarization noise than maps from the Planck satellite, the high-resolution sky maps will constrain cosmological parameters derived from the damping tail, gravitational lensing of the microwave background, the primordial bispectrum, and the thermal and kinematic Sunyaev-Zel'dovich effects, and will aid in delensing the large-angle polarization signal to measure the tensor-to-scalar ratio. The survey will also provide a legacy catalog of 16,000 galaxy clusters and more than 20,000 extragalactic sources.

The global recognition of eco‐friendly products like plant‐based dyes is escalating, driven by their exceptional biological and Ayurvedic attributes. This study isolates colorants from mango turmeric (Curcuma aromatica) using ultrasonic irradiation, supplemented with bio‐mordants to enhance color retention. Through the utilization of Response Surface Methodology and Central Composite Design, a technique that was optimized was completed to maximize coloring variables using statistical analysis. Results from 32 experimental runs reveal that optimal color depth (K/S = 19.399) was achieved with ultrasonic‐treated silk fabric (20 min exposure) using 65 mL of irradiated aqueous extract (20 min) with a pH of 5, supplemented with 1.5 g/100 mL salt of sodium chloride, maintained the temperature 75°C for the 45 min. Precoloring treatment with acacia, pomegranate, and pistachio extracts at specified concentrations enhanced colorfastness. Postdyeing, alterations in the concentrations of these extracts led to further improvements in colorfastness. Notably, adding Al+3 and Fe+2 salts, alongside tannic acid, exhibited notable effects in both pre‐ and postdyeing stages. While the colorfastness properties of unmordated silk fabric was lower than mordanted dyed silk fabric. Irradiation with ultrasonic waves significantly boosted the amount of dye that could be extracted from rhizomes of mango turmeric. Moreover, the application of bio and synthetic mordants in a strategic manner led to colorfastness ratings on silk fabric that ranged from excellent to satisfactory. This research underscores ultrasonic technologies and bio‐mordants' efficacy in sustainable dyeing processes, offering insights for developing eco‐friendly textile coloration methods. [ABSTRACT FROM AUTHOR]

Carrot (Daucus carota L.) is a nutrient-rich vegetable that is widely cultivated and consumed in Pakistan in both raw and processed form. Data on the proximate composition and natural occurrence of aflatoxins (AFs) in carrots and marketed carrot products is lacking in Pakistan and the risk exposure of AF has not been characterised before. Thus, the current study was designed to know the frequently consumed carrot products with per capita consumption, and risk assessment of AF through these products in various regions of South Punjab Pakistan. A survey was conducted with 125 respondents and appeared that raw carrot, fresh carrot juice, gajrella and pickle are the most frequently consumed marketed carrot products with per capita consumption i.e. 62.5, 46.6, 16.2 and 14.5 gday-1, respectively. Proximate analysis revealed that carrot root and processed carrot products contained 9.65–98.2% moisture, 0.23–0.60% ash, 6.2–14.1% carbohydrates, 0.31–0.80% protein, 0.40–3.7% fat and 1.4–4.20% fibre. AF analysis revealed that 36.67% of samples were contaminated with TAF. Thirty-five (35%) percent of samples were tainted with aflatoxin B1, and 13.33% of samples were contaminated with aflatoxin B2. All the samples of carrot root, fresh carrot juice and gajrella contained TAF levels less than the maximum limit (ML) (2 ppb) assigned by the European Union (EU). However, the entire AFB1 positive samples of carrot pickle contained AFB1 levels of more than 2 ppb exceeding the ML. Furthermore, daily dietary exposure of TAFs ranged from 0.11 to 1.27 ng/kg of body weight per day which relatively exceeds the permissible limit of 1 ng/kg of body weight per day as defined by the Joint FAO/WHO Expert Committee on Food Additives. This is the first prevalence and risk assessment report of AF in marketed processed carrot products in Pakistan. These baseline data are an initial step in the effort to deal with this significant food safety issue and the establishment of legislation for AF in marketed products is needed in Pakistan. [ABSTRACT FROM AUTHOR]

Background: Wastewater is a major source of Antibiotic-Resistant Bacteria (ARB) and a hotspot for the exchange of Antibiotic-Resistant Genes (ARGs). The occurrence of Carbapenem-Resistant Bacteria (CRB) in wastewater samples is a major public health concern. Objectives: This study aimed to analyze Antibiotic resistance in bacteria from wastewater sources in Pakistan. Methods: We analyzed 32 bacterial isolates, including 18 Escherichia coli, 4 Klebsiella pneumoniae, and 10 other bacterial isolates using phenotypic antibiotic susceptibility assay and whole-genome sequencing. This study identified the ARGs, plasmid replicons, and integron genes cassettes in the sequenced isolates. One representative isolate was further sequenced using Illumina and Oxford nanopore sequencing technologies. Results: Our findings revealed high resistance to clinically important antibiotics: 91% of isolates were resistant to cefotaxime, 75% to ciprofloxacin, and 62.5% to imipenem, while 31% showed non-susceptibility to gentamicin. All E. coli isolates were resistant to cephalosporins, with 72% also resistant to carbapenems. Sequence analysis showed a diverse resistome, including carbapenamases (blaNDM-5, blaOXA-181), ESBLs (blaCTX-M-15, blaTEM), and AmpC-type β-lactamases (blaCMY). Key point mutations noticed in the isolates were pmrB_Y358N (colistin) and ftsI_N337NYRIN, ftsI_I336IKYRI (carbapenem). The E. coli isolates had 11 different STs, with ST410 predominating (28%). Notably, the E. coli phylogroup A isolate 45EC1, (ST10886) is reported for the first time from wastewater, carrying blaNDM-5, blaCMY-16, and pmrB_Y358N with class 1 integron gene cassette of dfrA12-aadA2-qacEΔ1 on a plasmid-borne contig. Other carbapenamase, blaNDM-1 and blaOXA-72, were detected in K. pneumoniae 22EB1 and Acinetobacter baumannii 51AC1, respectively. The integrons with the gene cassettes encoding antibiotic resistance, and the transport and bacterial mobilization protein, were identified in the sequenced isolates. Ten plasmid replicons were identified, with IncFIB prevalent in 53% of isolates. Combined Illumina and Oxford nanopore sequencing revealed blaNDM-5 on an IncFIA/IncFIC plasmid and is identical to those reported in the USA, Myanmar, and Tanzania. Conclusions: These findings highlight the environmental prevalence of high-risk and WHO-priority pathogens with clinically important ARGs, underscoring the need for a One Health approach to mitigate ARB isolates. [ABSTRACT FROM AUTHOR]

Lignin is nature's second most abundant vascular plant biopolymer, playing significant roles in mechanical support, water transport, and stress responses. This study identified 90 lignin biosynthesis genes in rice based on phylogeny and motif constitution, and they belong to PAL, C4H, 4CL, HCT, C3H, CCoAOMT, CCR, F5H, COMT, and CAD families. Duplication events contributed largely to the expansion of these gene families, such as PAL, CCoAOMT, CCR, and CAD families, mainly attributed to tandem and segmental duplication. Microarray data of 33 tissue samples covering the entire life cycle of rice suggested fairly high PAL, HCT, C3H, CCoAOMT, CCR, COMT, and CAD gene expressions and rather variable C4H, 4CL, and F5H expressions. Some members of lignin-related genes (OsCCRL11, OsHCT1/2/5, OsCCoAOMT1/3/5, OsCOMT, OsC3H, OsCAD2, and OsPAL1/6) were expressed in all tissues examined. The expression patterns of lignin-related genes can be divided into two major groups with eight subgroups, each showing a distinct co-expression in tissues representing typically primary and secondary cell wall constitutions. Some lignin-related genes were strongly co-expressed in tissues typical of secondary cell walls. Combined HPLC analysis showed increased lignin monomer (H, G, and S) contents from young to old growth stages in five genotypes. Based on 90 genes' microarray data, 27 genes were selected for qRT-PCR gene expression analysis. Four genes (OsPAL9, OsCAD8C, OsCCR8, and OsCOMTL4) were significantly negatively correlated with lignin monomers. Furthermore, eleven genes were co-expressed in certain genotypes during secondary growth stages. Among them, six genes (OsC3H, OsCAD2, OsCCR2, OsCOMT, OsPAL2, and OsPAL8) were overlapped with microarray gene expressions, highlighting their importance in lignin biosynthesis. [ABSTRACT FROM AUTHOR]

Management of molasses-based wastewater generated in yeast and sugar industries is a major environmental concern due to its high chemical oxygen demand and other recalcitrant substances. Several strategies have been used to reduce the inland discharge of wastewater but the results are not satisfactory due to high operating cost. However, reuse of molasses-based wastewater irrigation in agriculture has been a major interest nowadays to reduce the freshwater consumption. Thus, it is crucial to monitor the impacts of molasses-based waste water irrigation on growth, metabolism, yield and nutritional quality of crops for safer consumer's health. In present study, carrot seeds of a local cultivar (T-29) were germinated on filter paper in Petri dishes under controlled conditions. The germinated seeds were then transplanted into pots and irrigated with three different treatments normal water (T0), diluted molasses-based wastewater (T1), and untreated molasses-based wastewater (T2), in six replicates. Results revealed that carrot irrigated with untreated molasses-based waste water had exhibited significant reductions in growth, yield, physiology, metabolism, and nutritional contents. Additionally, accumulation of Cd and Pb contents in carrot roots irrigated with untreated molasses-based waste water exceed the permissible limits suggested by WHO and their consumption may cause health risks. While, diluted molasses-based waste water irrigation positively enhanced the growth, yield of carrot plants without affecting the nutritional quality. This strategy is cost effective, appeared as most appropriate alternative mean to reduce the freshwater consumption in water deficit regions of the world. [ABSTRACT FROM AUTHOR]

Excessive use of inorganic fertilizers disrupts soil nutrient balance and leads to soil degradation and a decrease in biodiversity. In contrast, bio-fertilizers enhance soil structure and fertility and promote plant growth and sustainable agriculture development. Therefore, this study focused on a rotation system of winter wheat and summer maize and aimed to explore the effects of applying chemical fertilizer (NPK) and bio-fertilizer (BF) in the winter wheat season on the sustainable soil development of current wheat and subsequent maize. Before sowing winter wheat four fertilization treatments were, respectively CK (100% NPK at 750 kg ha−1), A (60% NPK at 450 + 20% BF at 150 kg ha−1), B (60% NPK at 450 + 40% BF at 300 kg ha−1), and C (60% NPK at 450 + 60% BF at 450 kg ha−1), conducted. The results showed that treatment A (60% NPK + 20% BF) replacing the NPK at 300 kg ha−1 with BF at 150 kg ha−1 significantly soil nutrient contents, enzyme activity, and microbial metabolic activity. The study also found a positive correlation between soil parameters (total nitrogen, alkaline nitrogen, available phosphorus, organic matter, urease, and alkaline phosphatase in the winter wheat and maize cropping season). Furthermore, the soil microbial composition showed significant enrichment of Proteobacteria, Acidobacteria, Actinobacteria, and Firmicutes, and variations among treatments. Moreover, the application of biofertilizer enhanced the diversity of soil fungi species, particularly during the winter wheat season. This study highlights the importance of integrating biofertilizers with NPK fertilizer for agricultural system conversion and promoting agricultural production and sustainability. [ABSTRACT FROM AUTHOR]

Global warming poses a significant threat to plant ecosystems and agricultural productivity, primarily through heat stress (HS), which disrupts photosynthesis, respiration, and overall plant metabolism. Epigenetic modifications, including DNA methylation, histone modifications, and RNA modifications, enable plants to dynamically and heritably adjust gene expression in response to environmental stressors. These mechanisms not only help plants survive immediate stress but also confer stress memory, enhancing their resilience to future HS events. This review explores the mechanisms underlying plant thermotolerance, emphasizing the critical role of epigenetic regulation in adapting to HS. It also highlights how DNA methylation modulates stress-responsive genes, histone modifications facilitate transcriptional memory, and RNA modifications influence mRNA stability and translation. Recent advancements in genome editing technologies, such as CRISPR-Cas9, have enabled precise modifications of epigenetic traits, offering new avenues for breeding climate-resilient crops. The integration of these modern tools with traditional breeding methods holds significant promise for developing crops with enhanced thermotolerance. Despite the potential, challenges such as the stability and heritability of epigenetic marks and the complex interplay between different epigenetic modifications need to be addressed. Future research should focus on elucidating these interactions and identifying reliable epigenetic markers for selection. By leveraging the insights gained from epigenetic studies, we can develop innovative breeding strategies to improve crop resilience and ensure sustainable agricultural productivity in the face of global warming. This review underscores the importance of epigenetic regulation in plant adaptation to heat stress and its potential to revolutionize crop breeding, offering a pathway to secure food production and sustainability under changing climatic conditions. [ABSTRACT FROM AUTHOR]

Rock physics provides a dynamic tool for quantitative analysis by developing the basic relationship between fluid, lithological, and depositional environment of the reservoir. The elastic attributes such as impedance, density, velocity, V p/V s ratio, Mu-rho, and Lambda-rho are crucial parameters to characterize reservoir and non-reservoir facies. Rock physics modelling assists like a bridge to link the elastic properties to petrophysical properties such as porosity, facies distribution, fluid saturation, and clay/shale volume. A robust petro-elastic relationship obtained from rock physics models leads to more precise discrimination of pay and non-pay facies in the sand intervals of the study area. The Paleocene aged Lower Ranikot Formation and Pab sandstone of Cretaceous age are proven reservoirs of the Mehar gas field, Lower Indus Basin. These sands are widely distributed in the southwestern part of the basin and are enormously heterogeneous, which makes it difficult to distinguish facies and fluid content in the reservoir intervals. So, an attempt is made in this paper to separate the reservoir facies from non-reservoir facies by using an integrated approach of the petro-elastic domain in the targeted sand intervals. Furthermore, missing logs (S-sonic and P-sonic) were also synthesized in the wells and missing intervals along with improving the poor quality of the density log by captivating the washouts and other side effects. The calibrated rock physics model shows good consistency between measured and modelled logs. Petro-elastic models were predicted initially using petrophysical properties and incorporated at true reservoir conditions/parameters. Lithofacies were defined based on petrophysical cut-offs. Rock physics modelled elastic properties (Lambda-rho versus Mu-rho, impedance versus V p/V s ratio) were then cross-plotted by keeping lithofacies in the Z-axis. The cross-plots clearly separated and demarcated the litho-fluid classes (wet sand, gas sand, shale, and limestone) with specific orientation/patterns which were randomized in conventional petrophysical analysis.

Non-Newtonian materials have been an appealing topic for researchers because of the variety of laboratory and industrial process involving these fluids. There are several kinds of non-Newtonian fluids classified according to their properties. In this study, the Maxwell fluid model is analyzed due to the unique properties and applications of this non-Newtonian material. We have considered the Buongiorno model for nanofluid, which is a two-phase model that accounts for the effects of Brownian motion and thermophoresis on the transport of nanoparticles in a fluid. A stretching surface holding a chemically reactive fluid is assumed. In addition, the study also considers the impacts of heat flux and magnetic fields. The influence of various physical factors on the flow fields is presented and graphically highlighted. Using linear regression and the data point approach, the relationship between the physical parameters, such as rate of heat and mass transfer, at the surface is investigated. The relationship between the various physical parameters was investigated using the t-test approach. The Maxwell fluid parameter influences heat transmission at the surface. As the magnetic field and heat source parameters increases, the rate of heat transfer decreases. Increasing the Deborah number, chemical reaction parameter and magnetic field parameter enhances the mass transfer rate at the surface. The fluid's velocity decreases with rising magnetic field and Maxwell fluid parameters. The heat source parameter elevates fluid temperature, while inclusion of the chemical reactions parameter reduces nanoparticle concentration. [ABSTRACT FROM AUTHOR]

This paper emphasizes the integration of wind and photovoltaic (PV) generation with battery energy storage systems (BESS) in distribution networks (DNs) to enhance grid sustainability, reliability, and flexibility. A novel multi‐objective optimization framework is introduced in this study to minimize energy supply costs, emissions, and energy losses while improving voltage deviation (VD) and voltage stability index (VSI). The proposed framework comprising normal boundary intersection (NBI) and decomposition‐based evolutionary algorithms (DBEA) determines the optimal siting and sizing of renewable‐based distributed resources, considering load demand variations and the intermittency of wind and solar outputs. The comparative analysis establishes that the proposed strategy performs better than many contemporary algorithms, specifically when all the objective functions are optimized simultaneously. The validation of the proposed framework was carried out on the standard IEEE‐33 bus test network, which demonstrates significant percentage savings in energy supply costs (49.6%), emission rate (62.2%), and energy loss (92.3%), along with enormous improvements in VSI (91.9%) and VD (99.8953%). The obtained results categorically underline the efficiency, reliability, and robustness of the proposed approach when employed on any complex distribution network comprising multiple renewable energy sources and battery storage systems. [ABSTRACT FROM AUTHOR]

Renewable energy, particularly wind energy, is expected to contribute significantly to the overall power generation. Induction machines are extensively used as generators in wind power generation because of their multiple benefits, such as robustness, reliability, and low cost and maintenance. However, due to the reactive power demand from the system to which they are connected, this type of generator brings new problems related to power quality, generally consisting of voltage regulation and reactive power compensation. These problems may cause voltage drops and dynamic instability. This study presents a metaheuristic method to attain a microgrid system with an optimal distribution based on its different constraints. The numerical model of an induction generator constructed in MATLAB/Simulink was used, and the simulation results obtained demonstrate the efficacy of the proposed metaheuristic technique. [ABSTRACT FROM AUTHOR]

Objective The aim of this study was to evaluate overdilation of 10-mm standard and 8–10 mm controlled-expansion Viatorr stents to 12 mm during transjugular intrahepatic portosystemic shunt (TIPS) placement when insufficient reduction (<50%) in portosystemic gradient (PSG) is achieved with standard 10 mm dilation. Materials and Methods It is a single-institution, institutional review board-approved, retrospective review of TIPS (2013–2022) to identify patients in the overdilation group (12 mm dilation of a 10-mm stent) and a control group (10 mm dilation of a 10-mm stent) matched for age, indication, stent type, Model for End-Stage Liver Disease (MELD) score, pre-TIPS PSG, and variceal embolization. Stent diameter, technical success, clinical outcomes, and adverse events were assessed for both groups. Results TIPS was created for the overdilation group (n = 35, 57 ± 11 years, 69% male; MELD: 14 ± 5) and control group (n = 35, 57 ± 11 years, 83% male; MELD: 14 ± 5). Overdilation to 12 mm adequately reduced PSG by more than 50% (55 vs. 65% in the control group, p = 0.11). The stent diameter was larger in the overdilation group on cross-sectional imaging (9.8 ± 0.2 vs. 9.5 ± 0.4 mm, p < 0.001), with an estimated 57% higher volume flow rate (p = 0.002). Patients were followed for a median of 11.3 months (range: 0.03–75) and 15.6 months (range: 0.03–106) in the overdilation and control groups, respectively. There was an equivalent rate of ascites resolution (56 vs. 63%, p = 0.68) and rebleeding (13 vs. 17%, p = 0.82) in the overdilation and control groups, with a similar risk of new-onset hepatic encephalopathy (41 vs. 33%, p = 0.51) and TIPS occlusion (11 vs. 9%, p = 0.69). Overdilation did not result in any instance of stent fracture. Conclusion Overdilation of 10-mm Viatorr stents with 12 mm balloons may provide benefit by potentially reducing PSG further for patients initially having inadequate PSG reduction with short-term safety. [ABSTRACT FROM AUTHOR]