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Introducción: existe una alta carga de enfermedad neuroquirúrgica en el mundo. La información sobre patología neuroquirúrgica en Perú es limitada. Objetivo. El objetivo del estudio es describir las características epidemiológicas y la distribución temporal de la patología neuroquirúrgica en un centro de alta complejidad. Material y Métodos: se realizó un estudio transversal analítico usando el registro de cirugías del servicio de neurocirugía del Hospital Nacional María Auxiliadora, en Lima-Perú entre 2008 y 2020. Se categorizó a los diagnósticos según la patología primaria en 10 categorías; y los diagnósticos específicos correspondientes a cada patología primaria. Se describieron frecuencias absolutas y relativas según patología. La distribución temporal se describió mediante un mapa de calor. Se usó la prueba de chi cuadrado para evaluar asociación entre los diagnósticos y el sexo. Resultados: se realizaron 2948 procedimientos quirúrgicos. La mediana de la edad fue de 38 años; y el 66,7% fue del sexo masculino. Los diagnósticos de traumatismo encefalocraneano, hidrocefalia y patología vascular representan el 60,0% de la carga de enfermedad neuroquirúrgica en el centro de estudio. El 20,2% de los TECs fueron hematomas subdurales crónicos y el 19,4% fueron hematomas epidurales. El 7,4% de todos los procedimientos fueron reintervenciones. Se encontró asociación entre el sexo y el diagnóstico primario (p < 0.001). Conclusiones: Los diagnósticos primarios más frecuentes fueron el traumatismo encefalocraneano, la hidrocefalia y los eventos vasculares. Es necesario comprender mejor el perfil de carga de enfermedad neuroquirúrgica en Perú.

Background Patients with inflammatory bowel disease (IBD) are at an increased risk of malnutrition. The goal of this study was to define the prevalence of malnutrition and micronutrient deficiencies in recently diagnosed IBD patients and to compare the performance of existing malnutrition screening tools in identifying IBD patients at increased risk for malnutrition. Methods This was a retrospective cohort study of adult patients with recently diagnosed IBD (≤18 months disease duration). A diagnosis of malnutrition was made utilizing the European Society for Clinical Nutrition and Metabolism malnutrition criteria. Serum micronutrient levels were included. The sensitivity of 5 malnutrition screening tools in identifying patients at moderate-high risk of malnutrition was determined based on the European Society for Clinical Nutrition and Metabolism malnutrition definition. Descriptive statistics summarized the data and univariate analyses tested associations. Results A total of 182 patients were included for analysis; 65 (36%) met criteria for malnutrition. A total of 135 (74%) patients had ≥1 micronutrient level checked and 105 (78%) had ≥1 deficiency. Patients with prior surgery (odds ratio [OR], 4.5; P = .004), active Crohn’s disease (OR, 2.8; P = .03), and diarrhea (OR, 2.1; P = .02) were more likely to be malnourished. The Malnutrition Universal Screening Tool and Saskatchewan IBD Nutrition Risk Tool had the highest sensitivity (100%) in predicting those at moderate-high risk of malnutrition at the time of screening. Conclusions Patients with recently diagnosed IBD have a high prevalence of malnutrition and micronutrient deficiencies. Both the Malnutrition Universal Screening Tool and Saskatchewan IBD Nutrition Risk Tool can be used to identify those at increased risk of malnutrition. Future studies and screening tool development are necessary to identify those at risk of developing malnutrition to facilitate timely referral for nutritional evaluation and prevent disease related complications.

The commonly accepted definition of sustainability considers the availability of relevant resources to make an activity feasible and durable while also recognizing users’ support as an essential part of the social side of sustainability. IoT represents a disruption in the general scenario of computing for both users and professionals. The real expansion and integration of applications based on IoT depend on our capacity of exploring the necessary skills and professional profiles that are essential for the implementation of IoT projects, but also on the perception of relevant aspects for users, e.g., privacy, legal, IPR, and security issues. Our participation in several EU-funded projects with a focus on this area has enabled the collection of information on both sides of IoT sustainability through surveys but also by collecting data from a variety of sources. Thanks to these varied and complementary sources of information, this article will explore the user and professional aspects of the sustainability of the Internet of Things in practice.

Primary effusion lymphoma (PEL) is a rare non-Hodgkin lymphoma confined exclusively to body cavities without detectable tumor masses. The term PEL-like is an entity similar to PEL in clinical presentation but without relation to human herpesvirus 8 (HHV8). We report a case of HHV8- and EBV-negative primary effusion-based lymphoma.

Desde BID Lab creemos que el uso de soluciones tecnológicas en la agricultura y las cadenas de valor agropecuaria ayudarán a reducir las brechas de productividad de forma más sostenible, apoyar a los productores a diseñar estrategias frente a las crisis climáticas; asegurar la inclusión de los pequeños y medianos productores, que representan el 80% del universo de productores de América Latina y el Caribe; y apoyar el acceso a alimentos nutritivos de la población más vulnerables de nuestra región. Mucho se habla y se ha escrito de la tecnología blockchain y su potencial uso en el sector agropecuario. Esta publicación tiene por objetivo contribuir a la agenda de conocimiento vinculados al uso de esta nueva tecnología, a través de casos concretos que permitan un análisis crítico al lector. Los casos analizados de América Latina y el Caribe confirman el potencial de la tecnología en materia de identidad, trazabilidad y finanzas. Al mismo tiempo revelan grandes desafíos para su adopción, acceso a nuevas fuentes de financiación y generación de ingresos. Es esperable que la evolución de la tecnología y del marco regulatorio favorezcan la innovación y permitan tanto la consolidación de estos proyectos como el surgimiento de nuevos tipos de soluciones, transformándose en una gran oportunidad para promover la inclusión de pequeños productores y medianos productores a través de la innovación por parte de los actores privados, públicos y sociedad civil.

Risk factors and outcomes of GF after TCD haploidentical transplantation in children with hematological malignancies were analyzed. 148 TCD transplants were included. 78 patients were diagnosed of ALL and 70 patients of AML. 22 out of 148 patients developed GF. MVA showed that patient

The Metropolitan Area of Mendoza (MMA), Argentina, has extended towards peripheral hillside areas without considering the environmental impact of this action. This growth has continued the urban model of flatland development, causing changes in the ecosystem and an increase in outdoor air temperature. This work proposes and evaluates urban schemes that incorporate design criteria with the objective of preserving environmental characteristics and mitigating the effect of urbanization on the microclimate. The proposed grid layouts, located in three predominant slopes, were linear organic and Cul-de-Sac. Methodologically, the microclimatic response of the proposed schemes was evaluated by applying ENVI-met software simulation. The results show that urban growth is possible when carefully considering environmental limitations which grant maximum air temperature reductions of up to 2 °C.

This chapter offers a longitudinal study on the financing of public relations projects through the State Plans for Scientific and Technical Research and of Innovation between the years 2013 and 2020. This is a descriptive paper, whose main object is to analyze the research evolution executed in the discipline of public relations via the latest State Plans for Scientific and Technical Research and of Innovation. The conclusions of the chapter reveal that in the last year the granting of research aid has increased substantially. Within the set of communication, public relations are still the most relevant topic receiving priority attention in research.

Mobilization regimes in pediatric patients at high risk for poor mobilization are not standardized across different institutions. We present a retrospective analysis of our experience with a high-dose granulocyte colony-stimulating factor (G-CSF) regime of 12 μg/Kg per body weight (BW) twice a day for 4 days used in high-risk patients.We report the results of all pediatric patients mobilized with high-dose G-CSF between January 1999 and February 2021 in our center. A successful mobilization was defined as a peripheral blood (PB) CD34Of the 262 patients included in the analysis, mobilization failure was found in 27 (10.3%). In a univariate analysis, this was associated with age, weight, baseline diagnosis, and having undergone a previous mobilization cycle, the latter being the only factor that remained significantly associated in a multivariate analysis (P = 0.03). The 54 patients (20.6%) did not reach the minimum required CD34Although most high-risk pediatric patients are successfully mobilized with the high-dose G-CSF regime, this approach does not salvage all of them and significantly increases the presence of AEs in comparison to standard-dose regimes.

INTRODUCTION In order to propose risk-adapted mobilization algorithms, several authors have tried to look for predictive factors of the CD34+ yield in healthy pediatric donors. Donor recipient body weight ratio (D/R ratio) was identified as one of the main variables related with the success to achieve the target cell dose for transplantation. According to this variable we modified the mobilization schedule. MATERIAL AND METHODS We report the results of 46 mobilizations and apheresis procedures performed in our center with unfavorable D/R ratio. Mobilization was attempted by the standard regime of G-CSF (10 mcg/kg/24 hours) in 28 cases (60.9%), with high dose G-CSF (10 mcg/kg/12 hours) in 9 cases (19.6%), and with plerixafor and G-CSF single dose regime in 9 cases (19.6%). RESULTS CD34+ cell quantification before apheresis is closely related to CD34+ yield, being the only factor related to collected CD34+ cells (beta .71; P

Introducción: Esta investigación se ocupa de estudiar cómo los think tanks españoles utilizan el medio digital para difundir su actividad y transmitir sus ideas. Metodología: A través del análisis de contenido, se analiza qué tipos de herramientas de comunicación emplean en los espacios digitales que implementan de manera oficial (webs y medios sociales), así como la utilización de estas como canales unidireccionales o bidireccionales. Resultados: Se muestra que los unidireccionales se centran en la difusión de la identidad de estas organizaciones, muy vinculada a las actividades formativas. Entre los bidireccionales, cobran relevancia los medios sociales, que se emplean para la generación de compromiso con sus públicos. Discusión y conclusiones: Los thinks tanks utilizan la comunicación digital como estrategia de difusión de sus actividades. Eso supone potenciar la prospectiva de advocacy y una pretensión de participar en los temas de discusión pública con propuestas sobre sus encuadres (Bürger, 2015, Misztal, 2012).

Penetrating aortic ulcer (AU) is defined as localized disruption of the intimal layer of the aortic wall, resulting in a crater-like lesion outpouching from the vessel contour. AU is a generic term which encompasses a constellation of entities with different etiologies and prognoses and may be a complication of infective, inflammatory, traumatic, iatrogenic, atherosclerotic processes or intramural hematoma. One of the most challenging scenarios of AU for a differential diagnosis, but also for treatment implications, is when they are associated with acute aortic syndrome. Despite advances in the field of aortic disease, lack of consensus defining these lesions and the significant semantic confusion in the medical literature of the acronym PAU (for penetrating aortic ulcer but also for penetrating atherosclerotic ulcer) have given rise to controversy in guidelines and expert consensus, leading to the same treatment being recommended for entities with different etiology and prognosis. Moreover, in the medical literature, most diagnoses were mainly based on imaging techniques which identified AU regardless of clinical symptoms, surrounding imaging findings or dynamic morphologic changes. In this Review, we provide the latest insight into the differential diagnosis between AU, also called penetrating aortic ulcers, based on clinical context and the newest imaging characteristics to aid treatment decision-making.

This paper examines the situation of e-commerce and m-commerce in SMEs in the European Union and analyses if their behaviour in this field is determined by a series of factors, such as the size of the company, the type of business, turnover, etc. which may also influence their needs of specific training for their employees. This study is based on an online survey responded by 674 SMEs from eight different countries in Europe, aimed at providing training assistance to SMEs to support their efforts towards m-commerce. The objective is the analysis of the skills and knowledge to be recommended to employees of SMEs for a better preparation to implement the companies' strategy of m-commerce. Although analysis of results from survey has supported the initial goal of developing training courses for m-commerce which include different economic, legal and technical topics, it has mainly provided very relevant conclusions on the factors which impact the adoption of e-commerce and m-commerce by SMEs.

En las sociedades democráticas los medios de comunicación juegan un papel clave como elemento facilitador de la conexión entre los poderes políticos y la ciudadanía. La percepción pública de la reputación mediática puede suponer un factor clave para fortalecer la confianza y activar el compromiso ciudadano. Este artículo presenta un estudio de la reputación de la prensa en papel, la prensa digital, la radio y la televisión en 10 países europeos: Austria, Bélgica, Francia, Alemania, Italia, Polonia, Portugal, Rumanía, Suecia y Reino Unido. El análisis desarrollado sigue una metodología empírica, basada en la realización de una encuesta para conocer la reputación atribuida a los medios de comunicación por parte de una muestra de la población informada de esos países (1000 residentes, mayores de edad, usuarios de medios al menos dos o tres veces por semana). Se caracteriza, así, el concepto de reputación en su asociación con medios de comunicación, identificándose los atributos integradores de la reputación mediática y valorando su incidencia en la reputación de cada medio. Los resultados indican que, aunque la televisión es el medio más usado, la prensa en papel goza de mayor reputación en la mayoría de los países analizados, apreciándose una destacada asociación de este medio con los atributos de credibilidad y rigor informativo. El artículo ofrece una detallada descripción de las valoraciones de cada atributo integrante de la reputación mediática en cada uno de los países analizados. Finalmente, se aporta un ranking de los medios que gozan de mayor reputación en los países europeos examinados, así como una descripción del posicionamiento reputacional de cada medio estudiado. Abstract Democracy is considered to be the ideal foundation of societies today. In a democratic society, news media play a highly relevant role as avenues by which public and political powers can interact with society and facilitate civic participation. The public’s perception of the news media’s reputation is a crucial factor for enhancing trust and citizen engagement. This article presents a study of the reputation of the media (paper press, digital press, radio and television) in ten European countries: Austria, Belgium, France, Germany, Italy, Poland, Portugal, Romania, Sweden, and the United Kingdom. A quantitative method was applied to the results of a survey conducted to determine the reputation of news media among a sample of the informed population in those countries (1,000 residents of legal age who used media at least two or three times a week). The concept of reputation is thereby characterized in its association with the media, identifying its integrating attributes and assessing its incidence in each type of medium. The results indicate that, although television is the most widely used medium, the printed press enjoys a higher reputation in most of the countries studied, being seen as having the attributes of credibility and informative rigor. This study provides a detailed analysis of the scores given to media reputation attributes in the considered countries. It also offers a ranking of the media with the highest reputation in the countries examined, as well as a description of the reputational position of each medium.

A new clinical syndrome named Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) has been described. This new disease is a leading cause of hospital and paediatric intensive care unit (PICU). It has been related to immunity dysregulation. Prospective-retrospective observational study to describe the innate cell signature and immunophenotype of children admitted to PICU because of PIMS-TS (from March 2020 to September 2020). The immunophenotype was done through the expression analysis of these proteins of mononuclear cells: CD64, CD18, CD11a and CD11b. They were compared with previous healthy controls and children admitted to PICU because of bacterial infection, viral infection and Kawasaki disease (KD). Two hundred and forty-seven children were studied: 183 healthy controls, 25 viral infections, 20 bacterial infections, 6 KD and 13 PIMS-TS. PIMT-TS showed the lowest percentage of lymphocytes and monocytes with higher relative numbers of CD4+ (p = .000). Monocytes and neutrophils in PIMS-TS showed higher levels of CD64 expression (p = .000). Also, CD11a and CD11b were highly expressed (p =,000). We observed a differential cell innate signature in PIMS-TS. These findings are consistent with a proinflammatory status (CD64 elevated expression) and lymphocyte trafficking to tissues (CD11a and CD11b). More studies should be carried out to confirm our results.

Although children and adolescents with acute lymphoblastic leukaemia (ALL) have high survival rates, approximately 15-20% of patients relapse. Risk of relapse is routinely estimated at diagnosis by biological factors, including flow cytometry data. This high-dimensional data is typically manually assessed by projecting it onto a subset of biomarkers. Cell density and “empty spaces” in 2D projections of the data, i.e. regions devoid of cells, are then used for qualitative assessment. Here, we use topological data analysis (TDA), which quantifies shapes, including empty spaces, in data, to analyse pre-treatment ALL datasets with known patient outcomes. We combine these fully unsupervised analyses with Machine Learning (ML) to identify significant shape characteristics and demonstrate that they accurately predict risk of relapse, particularly for patients previously classified as ‘low risk’. We independently confirm the predictive power of CD10, CD20, CD38, and CD45 as biomarkers for ALL diagnosis. Based on our analyses, we propose three increasingly detailed prognostic pipelines for analysing flow cytometry data from ALL patients depending on technical and technological availability: 1. Visual inspection of specific biological features in biparametric projections of the data; 2. Computation of quantitative topological descriptors of such projections; 3. A combined analysis, using TDA and ML, in the four-parameter space defined by CD10, CD20, CD38 and CD45. Our analyses readily extend to other haematological malignancies.Author summaryAcute lymphoblastic leukaemia (ALL) is a blood cancer which affects predominantly children and adolescents. Therapy typically fails in approximately 20 % of patients, who suffer from relapse. To determine disease status, clinicians assess cell types, their interactions, as well as deviations from normal behaviour. Flow cytometry (FC) is a method that quantifies the intensity of specific cell markers, giving rise to high-dimensional data. This routinely collected information is then reduced to obtain human-interpretable visualisation for prognosis. Topological Data Analysis (TDA) is a field of mathematics that studies shapes in data, considering isolated data islands and empty spaces between them. We showcase how to use TDA to extract shape characteristics in FC data of relapsing patients. We propose three pipelines, of increasing methodological complexity, to aid clinical decisions for risk stratification in ALL. In combination with Machine Learning, TDA enables high-accuracy predictions of relapse to be made at the time of diagnosis.

This study investigates the influence of high-performance work systems (HPWSs) on expression of servant leadership style in hotel settings. More specifically, it examines how this can generate positive outcomes in work engagement and extra-role behavior in a sample of Spanish hospitality workers. The study's main purpose is to identify key organizational factors that induce positive employee outcomes in hospitality. Structural equation modelling with Amos was conducted to validate a sequential mediation model with two mediators. The results demonstrate that HPWSs create a propitious environment for managers' servant leadership and its positive effects on work engagement. The findings highlight the important role work engagement plays in encouraging employees' extra-role behavior. HR architecture and the manager's participatory orientation do not suffice to motivate employees to go the extra mile; it seems essential first to influence the psychological experience of work by nurturing work engagement. Theoretical contributions and implications for hospitality are highlighted.

En los últimos años las industrias creativas han ganado reconocimiento como sector productivo relevante a nivel mundial. Sin embargo, a pesar de que su potencial de desarrollo para la economía de Uruguay era significativo, las pequeñas y medianas empresas (pymes) de dicha industria no encontraban canales que les permitan innovar y desarrollar nuevos productos y modelos de negocio, en colaboración con otros sectores de la economía, en particular los de alta intensidad tecnológica. Por otro lado, también las pymes de sectores tradicionales, e incluso las tecnológicas, detectaban problemas en incorporar insumos creativos en sus procesos o productos finales.

This work analyzes the relationships between interest in the campaign for the 2019 Spanish general elections, the type of media used to follow it, and participation through conversations, disseminating electronic messages about the elections, and voting. A secondary data analysis of surveys published by the Spanish Centre for Sociological Research (CIS) is carried out. The existence of relationships between the variables is determined by using the chi-squared hypothesis test, while the strength of the associations is measured by means of the Cramér’s V and the contingency coefficient. Trends are examined by analyzing the conditioned relative frequencies. The results show a strong association between interest in the campaign and the type of medium chosen to obtain information. Likewise, there is a remarkable relationship between the interest of voters and their participation in conversations, especially in family environments, and in the dissemination of digital information about the elections. In contrast, the candidates’ arguments and pledges are not significantly related to the reason for voting. Similarly, demographic variables are weakly related with interest in the campaign, following it on the media, and participation by voting, with educational level being the only characteristic exhibiting moderately strong associations.

Social media is one of the most disruptive technologies in executing a firm’s digital business transformation strategies. Does the firm’s ability to use social media affect its proficiency in exploring and exploiting knowledge? What should be the role of business analytics talent in this equation? We study theoretically and empirically these cutting-edge research questions. Our proposed research model argues that social media capability enables the development of knowledge exploration and knowledge exploitation, and business analytics talent exerts a positive reinforcing role in the impact of social media on knowledge exploration. We empirically tested the proposed research model with a secondary dataset from a sample of US firms using PLS path modeling. After running a robustness test by estimating eight alternatives/competing models, the empirical analysis revealed that social media capability is positively related to knowledge exploration and knowledge exploitation, but with a stronger effect on knowledge exploration. Moreover, business analytics talent plays a positive moderator role in the relationship between social media capability and knowledge exploration. This study contributes to the IS research by (1) introducing, developing, and operationalizing the concepts of social media capability and business analytics talent; and (2) theoretically arguing and empirically showing the pivotal role of social media capability in exploring new knowledge and the complementary role of business analytics talent. Our study also provides several critical lessons learned for top executives and proposes promising future IS research avenues., European Regional Development Fund (European Union), Spanish Government ECO201784138-P FPU14/01930 FPU13/01643, Junta de Andalucia A-SEJ-154-UGR18, Endowed Chair of Digital Business Transformation at Rennes School of Business, Slovenian Research Agency - Slovenia P5-0410

Background: Ivermectin is a drug that has been shown to be active against coronavirus disease 19 (COVID-19) in previous studies. Healthcare personnel are highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Therefore, we decided to offer them ivermectin as a pre-exposure prophylaxis (PrEP) method. Purpose: Primary outcome was to measure the number of healthcare workers with symptomatic SARS-CoV-2 infection and a positive reverse transcription polymerase chain reaction (RT-PCR) COVID-19 test in the ivermectin group and in the control group. Secondary outcome was to measure the number of sick healthcare workers with a positive RT-PCR COVID-19 test whose condition deteriorated and required hospitalization and/or an Intensive Care Unit (ICU), or who died, in the ivermectin group and in the control group. Material and methods: This observational and retrospective cohort study was carried out in two medical centers, Centro Medico Bournigal (CMBO) in Puerto Plata and Centro Medico Punta Cana (CMPC) in Punta Cana, Dominican Republic. The study began on June 29, 2020, and ended on July 26, 2020. A Statistical Package for Social Sciences (SPSS) Propensity Score Matching procedure was applied in a 1:1 ratio to homogeneously evaluate 271 healthcare personnel that adhered to a PrEP program with ivermectin at a weekly oral (PO) dose of 0.2 mg/kg, and 271 healthcare personnel who did not adhere to the program were assigned as a control group. Results: In 28 days of follow-up, significant protection of ivermectin preventing the infection from SARS-CoV-2 was observed: 1.8% compared to those who did not take it (6.6%; p-value = 0.006), with a risk reduction of 74% (HR 0.26, 95% CI [0.10,0.71]). Conclusions: These results suggest that compassionate use of weekly ivermectin could be an option as a preventive method in healthcare workers and as an adjunct to immunizations, while further well-designed randomized controlled trials are developed to facilitate scientific consensus.

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado. Background: Pulmonary tuberculosis is a highly prevalent disease in low-income countries; clinical prediction tools allow healthcare personnel to catalog patients with a higher risk of death in order to prioritize medical attention. Methodology: We conducted a literature search on prognostic models aimed to predict mortality in patients diagnosed with pulmonary tuberculosis. We included prospective and retrospective studies where prognostic models predicting mortality were either developed or validated in patients diagnosed with pulmonary tuberculosis. Three reviewers independently assessed the quality of the included studies using the PROBAST tool (Prediction model study Risk of Bias Assessment Tool). A narrative review of the characteristics of each model was conducted. Results: Six articles (n = 3553 patients) containing six prediction models were included in the review. Most studies (5 out of 6) were retrospective cohorts, only one study was a prospective case-control study. All the studies had a high risk of bias according to the PROBAST tool in the overall assessment. Regarding the applicability of the prediction models, three studies had a low concern of applicability, two high concern and one unclear concern. Five studies developed new prediction rules. In general, the presented models had a good discriminatory ability, with areas under the curve fluctuating between 0.65 up to 0.91. Conclusion: None of the prognostic models included in the review accurately predict mortality in patients with pulmonary tuberculosis, due to great heterogeneity in the population and a high risk of bias. Revisión por pares

El estudio realizado entre BID Lab y Xcala busca reflexionar acerca de la evolución de emprendimientos invertidos en los útimos seis años a través de ángeles inversionistas en la región. El objetivo principal es sacar conclusiones para compartir con el ecosistema para así lograr una mejor toma de decisiones, identificar los desafios del proceso de levantamiento de capital y aportar ideas creativas para el diseño de estrategias orientadas a darle continuidad al fortalecimiento del ecosistema emprendedor en América Latina y el Caribe. El enfoque como objeto de análisis en el emprendimiento, permitirá conocer de primera mano acerca de cuales fueron esos aprendizajes claves y algunas de las tendencias que pueden ser capitalizadas por nuevos emprendimientos.

This work analyses the principles of strategic communication, taking the case of the Toms firm as an example in which business strategy aligns with strategic communication. It explains this company’s management style on how strategic communication is to be understood. Fundamentally, the Toms strategy focuses more on exploiting its potential to fulfil its mission in the long term (to sell and be an organisation standing for solidarity) than on applying resources or making partial, short-term communication decisions. Thus, the entire business model and all long-term business decisions can in themselves be regarded as strategic communication decisions since the business objective becomes a communication objective. In this way, each tactic and action put into play in the firm’s evolution provides it with social value and confers a constantly changing communicative dimension, which is only possible in nonlinear organisations whose business design is hypertextual or bidirectional.

Risk factors and outcomes of GF after TCD haploidentical transplantation in children with hematological malignancies were analyzed. 148 TCD transplants were included. 78 patients were diagnosed of ALL and 70 patients of AML. 22 out of 148 patients developed GF. MVA showed that patient9 years (HR: 5.0; 95% CI: 1.1-23.0

We sing and dance in praise of the butterfly— translucent blue, gilded wings, dances— all its life from orchid to cacao, ceiba to banana and fig, tying invisible strings that hold our home in the s...

This study aimed to assess the scientific production of bone lengthening research by identifying the most-cited papers. All articles including the term 'bone lengthening' published between 2001 and 2017 were retrieved through the Web of Science database. The 100 most-cited articles on bone lengthening included a total of 4244 citations, with 414 (9.7%) citations in 2017. There was an average of 249.6 citations per year. The articles predominantly addressed biomechanics and bone formation (38). Different surgical techniques, including intramedullary nail (14), Ilizarov (nine), intramedullary skeletal kinetic distractor (ISKD) (six), Taylor spatial frame (6), the PRECICE device (three), and lengthening and submuscular locking plate (three), were the second most-studied topic. Most studies were therapeutic (58), whereas 30 studies were experimental investigations using animal models. Among the clinical studies, case series were predominant (level of evidence IV) (57). This study presents the first bibliometric analysis of the most relevant articles on bone lengthening. The list is relatively comprehensive in terms of identifying the top issues in this field. However, the most influential clinical studies have a poor level of evidence, although a slight tendency toward a better level of evidence has been observed in more recent years.