101. Should NF2 mutation screening be undertaken in patients with an apparently isolated vestibular schwannoma?
- Author
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Naomi L. Bowers, Susan M Huson, Andrew J Wallace, Carolyn Gokhale, R. T. Ramsden, and D G R Evans
- Subjects
Adult ,Neurofibromatosis 2 ,congenital, hereditary, and neonatal diseases and abnormalities ,Pediatrics ,medicine.medical_specialty ,Adolescent ,DNA Mutational Analysis ,Population ,Schwannoma ,Germline mutation ,Risk Factors ,Genes, Neurofibromatosis 2 ,otorhinolaryngologic diseases ,Genetics ,medicine ,Humans ,Genetic Testing ,Age of Onset ,Neurofibromatosis type 2 ,Child ,education ,Germ-Line Mutation ,Genetics (clinical) ,Vestibular system ,education.field_of_study ,Mosaicism ,business.industry ,Neuroma, Acoustic ,Middle Aged ,medicine.disease ,Vestibular nerve ,England ,Mutation ,Mutation (genetic algorithm) ,Mutation testing ,business - Abstract
Early onset of vestibular schwannoma (VS) is associated with the inherited condition neurofibromatosis type 2 (NF2). However, the majority of NF2 presents bilaterally and the proportion of early-onset apparent sporadic unilateral VS because of NF2 remains to be determined. We have determined the risk by studying NF2 risk in a population-based set of VS, looking at the mode of presentation in a large NF2 data set and the outcome of NF2 mutation analysis in 148 sporadic unilateral VS. The risk of NF2 in an apparently sporadic case of unilateral VS is small apart from in the very youngest age group (
- Published
- 2007