123 results on '"Antonelli, Francesca"'
Search Results
102. Inactivation of human cells with different intrinsic radiosensitivity by carbon ion
- Author
-
Ando, Koichi, Antonelli, Francesca, Belli, Mauro, Bettega, Daniela, Paola, Calzolari, Cherubini, R, Durante, Marco, Furusawa, Yoshiya, Gialanella, G, Grossi, Giafranco, Paola, Massariello, Antonella, Pugliese Malia, Scampoli, P, Simone, Giustina, Sorrentino, Eugenio, Antonella, Tabocchini Maria, and Tallone, Lucia
- Abstract
There is a strong need for radiobiological experiments on carbon ions, to better determine the biological effectiveness as a function of radiation quality and to optimise the clinical use. The goal of this experiment is to measure biological effects of accelerated carbon ions in different cell lines with different radiosensitivity to photon radiation. Results will be used to determine the RBE of carbon ions for radiosensitive and radioresistant cells.
- Published
- 2002
103. UltraViolet SANitizing System for Sterilization of Ambulances Fleets and for Real-Time Monitoring of Their Sterilization Level.
- Author
-
Michelini, Zuleika, Mazzei, Chiara, Magurano, Fabio, Baggieri, Melissa, Marchi, Antonella, Andreotti, Mauro, Cara, Andrea, Gaudino, Alessandro, Mazzalupi, Marco, Antonelli, Francesca, Sommella, Lorenzo, Angeletti, Silvia, Razzano, Elena, Runge, Arnaud, and Petrinca, Paolo
- Published
- 2022
- Full Text
- View/download PDF
104. Poster session
- Author
-
Marucci, Elisabetta, primary, Antonelli, Francesca, additional, and Farina, Flavia, additional
- Published
- 1994
- Full Text
- View/download PDF
105. Femmes de sciences de l’ Antiquité au XIXesiècle. Réalités et représentations, edited by Adeline Gargam
- Author
-
Antonelli, Francesca
- Published
- 2017
- Full Text
- View/download PDF
106. Susceptibility to measles in migrant population: implication for policy makers.
- Author
-
Ceccarelli, Giancarlo, Vita, Serena, Riva, Elisabetta, Cella, Eleonora, Lopalco, Maurizio, Antonelli, Francesca, Cesaris, Marina De, Fogolari, Marta, Dicuonzo, Giordano, Ciccozzi, Massimo, Angeletti, Silvia, Porto, the Sanitary Bureau of the Asylum Seekers Center of Castelnuovo di, De Cesaris, Marina, and Sanitary Bureau of the Asylum Seekers Center of Castelnuovo di Porto
- Subjects
MEASLES prevention ,DISEASE susceptibility ,EPIDEMIOLOGICAL research ,IMMUNIZATION ,MEASLES ,MEASLES vaccines ,REFUGEES ,TRAVEL ,DISEASE prevalence - Abstract
Background: Despite a large measles outbreak is taking place in WHO European region, currently no data are available on measles immunization coverage in the asylum seeker and migrants hosted in this area.Methods: Two hundred and fifty-six migrants upon their arrival in Italy on March, April and May 2016 were screened for measles virus IgG antibodies by chemiluminescence immunoassay (Liaison XL analyzer, Diasorin, Italy). The virus susceptibility in this cohort, the differences between the official country reported and the observed measles immunization coverage and the impact of current measles outbreak on the asylum seekers hosted in the largest Asylum Seeker centres of Italy, were evaluated.Results: The prevalence of subjects with positive result for measles IgG antibodies ranged between 79.9% and 100%. In Senegal, Mali, Nigeria, Pakistan and Bangladesh, the measles IgG seroprevalence observed was greater than the vaccinal coverage reported by WHO after I dose of vaccine. Based on data regarding the II dose coverage, the ASs population presented a seroprevalence greater to that expected.Conclusion: On the basis of the results obtained, extraordinary screening and vaccination campaigns in the migrant population, especially in the course of large outbreaks, could represent a resource to reach an adequate measles immunization coverage and to control this infectious disease. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
107. Femmes de sciences de l'Antiquité au xixe siècle. Réalités et représentations.
- Author
-
Antonelli, Francesca
- Published
- 2017
- Full Text
- View/download PDF
108. "AAC and verbal dyspraxia The experience of a multidisciplinary treatment in developmental age to support autonomy in communication".
- Author
-
Amantis, Raffaela, Drigo, Flavia, Claudia, Bellini, Antonelli, Francesca, Zepponi, Barbara, and Corradi, Fabrizio
- Abstract
BACKGROUND: In verbal dyspraxia the capacity in verbal expression is variably affected and the ability to recognize words and understand the language is preserved. In a high percentage of cases there is an evident disorder of language comprehension especially the formal aspects (L. Sabbadini, 2005). PURPOSE: To present the value of Augmentative and Alternative Communication (AAC) treatment in a child of 6 years of age with a diagnosis of a specific language impairment and motor dyspraxia with a functional diagnosis in the communication which can be assimilated with verbal dyspraxia. METHOD: Based on studies (Bornman et al., 2001; Cumley & Swanson, 1999; Harris et intal., 1996) that suggest multimodal intervention of Alternative and Augmentative Communication (AAC) in children with verbal dyspraxia and with our team's experience in AAC intervention a gradual introduction of Picture Communication Symbols (PCS) was made to support spontaneous communication (verbal and gestural): beginning with only a few symbols in the rehabilitative setting to the shared construction of a communication book structured with primary and secondary charts used both at home and at school. The same material was used in speech therapy for the objective of amplification of the semantic, grammatical and lexical competences and metacognitive abilities. CONCLUSION: The use of AAC strategies resulted in an increase in the number of communicative partners and in the expressiveness and receptiveness of the little girl (Blackstone & Hunt Berg, 2003, 2012). The next phase involves verification the possibility of inserting high-tech communication systems. (Federici & Scherer, 2012). [ABSTRACT FROM AUTHOR]
- Published
- 2014
109. Poster session
- Author
-
Marucci, Elisabetta, Antonelli, Francesca, and Farina, Flavia
- Published
- 1994
- Full Text
- View/download PDF
110. Migrants rescued on the Mediterranean Sea route: nutritional, psychological status and infectious disease control.
- Author
-
Angeletti, Silvia, Ceccarelli, Giancarlo, Bazzardi, Riccardo, Fogolari, Marta, Vita, Serena, Antonelli, Francesca, De Florio, Lucia, Khazrai, Yeganeh Manon, De Noia, Vincenza, Lopalco, Maurizio, Alagia, Domenico, Pedone, Claudio, Lauri, Gaetano, Aronica, Rosario, Riva, Elisabetta, Demir, Ayse Banu, Abacioglu, Hakan, and Ciccozzi, Massimo
- Subjects
- *
TRADE routes , *COMMUNICABLE diseases , *PREVENTIVE medicine , *IMMIGRANTS , *EMERGING infectious diseases , *LIVING conditions - Abstract
Introduction: North Africa has become a key migratory hub where a large number of migrants attempt the journey by sea from the Libyan coastline to the south of Europe. In this humanitarian disaster scenario, the Mediterranean route has been one of the most used by illegal boats. Methodology: In this report, the state of physical and psychological health of a cluster of Eritrean migrants, escaped from Libya and rescued in the Mediterranean Sea after a shipwreck, was described by epidemiological, clinical and laboratory investigations. Results: Data suggest that despite the majority of the migrants being apparently in good health upon a syndromic surveillance approach, most of them suffered a decline in psychological status as well as severe malnutrition. The emergence of infectious diseases, related to poor living conditions during the journey, is not a rare event. Conclusion: The present report highlights the risks of failures of the syndromic medical approach in the setting of the extremely challenging migration route and underlines migrant frailties consequent to a prolonged journey and long period of detention. These stressors, which can degrade the initial health condition of traveling migrants, can lead to a premature "exhausted migrant effect" that should be carefully investigated in order to avoid the early emergence of diseases related to frailty. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
111. Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis
- Author
-
Anna Saran, Simona Leonardi, Francesca Antonelli, Gabriele Babini, Emanuela Pasquali, Barbara Tanno, Ilaria De Stefano, Arianna Casciati, Mariateresa Mancuso, Alessandro Pannicelli, Paola Giardullo, Simonetta Pazzaglia, Francesco Berardinelli, Antonella Sgura, Mirella Tanori, Pazzaglia, S., Saran, A., Mancuso, M., Pannicelli, A., Tanno, B., Antonelli, F., Pasquali, E., Leonardi, S., Casciati, A., Tanori, M., Tanori, Mirella, Casciati, Arianna, Berardinelli, Francesco, Leonardi, Simona, Pasquali, Emanuela, Antonelli, Francesca, Tanno, Barbara, Pannicelli, Alessandro, Babini, Gabriele, De Stefano, Ilaria, Sgura, Antonella, Mancuso, Mariateresa, Saran, Anna, and Pazzaglia, Simonetta
- Subjects
0301 basic medicine ,Senescence ,Expression profiles ,DNA repair ,DNA damage ,Poly ADP ribose polymerase ,Apoptosis ,Biology ,medicine.disease_cause ,03 medical and health sciences ,Germline mutation ,Expression profile ,Cerebellum ,medicine ,Genetics ,Medulloblastoma ,fungi ,Apoptosi ,medicine.disease ,030104 developmental biology ,Oncology ,Cancer research ,Homologous recombination ,Carcinogenesis ,Research Paper - Abstract
// Mirella Tanori 1 , Arianna Casciati 1 , Francesco Berardinelli 2 , Simona Leonardi 1 , Emanuela Pasquali 1 , Francesca Antonelli 1 , Barbara Tanno 1 , Paola Giardullo 2,3 , Alessandro Pannicelli 4 , Gabriele Babini 5 , Ilaria De Stefano 3 , Antonella Sgura 2 , Mariateresa Mancuso 1 , Anna Saran 1 and Simonetta Pazzaglia 1 1 Laboratory of Biomedical Technologies, Agenzia Nazionale per le Nuove Tecnologie, l’Energia e lo Sviluppo Economico Sostenibile (ENEA), CR-Casaccia, Rome, Italy 2 Department of Science, University Roma Tre, Rome, Italy 3 Department of Radiation Physics, Universita degli Studi Guglielmo Marconi, Rome, Italy 4 Technical Unit of Energetic Efficiency, ENEA, Rome, Italy 5 Department of Physics, University of Pavia, Pavia, Italy Correspondence to: Simonetta Pazzaglia, email: // Keywords : cerebellum, expression profiles, medulloblastoma, apoptosis, senescence Received : June 14, 2016 Accepted : June 26, 2016 Published : July 07, 2016 Abstract Mutations in DNA repair pathways are frequent in human cancers. Hence, gaining insights into the interaction of DNA repair genes is key to development of novel tumor-specific treatment strategies. In this study, we tested the functional relationship in development and oncogenesis between the homologous recombination (HR) factor Rad54 and Parp-1 , a nuclear enzyme that plays a multifunctional role in DNA damage signaling and repair. We introduced single or combined Rad54 and Parp-1 inactivating germline mutations in Ptc1 heterozygous mice, a well-characterized model of medulloblastoma, the most common malignant pediatric brain tumor. Our study reveals that combined inactivation of Rad54 and Parp-1 causes a marked growth delay culminating in perinatallethality, providing for the first time evidence of synthetic lethal interactions between Rad54 and Parp-1 in vivo . Although the double mutation hampered investigation of Rad54 and Parp-1 interactions in cerebellum tumorigenesis, insights were gained by showing accumulation of endogenous DNA damage and increased apoptotic rate in granule cell precursors (GCPs). A network-based approach to detect differential expression of DNA repair genes in the cerebellum revealed perturbation of p53 signaling in Rad54 -/- / Parp-1 -/- / Ptc1 +/- , and MEFs from combined Rad54/Parp-1 mutants showed p53/p21-dependent typical senescent features. These findings help elucidate the genetic interplay between Rad54 and Parp-1 by suggesting that p53/p21-mediated apoptosis and/or senescence may be involved in synthetic lethal interactions occurring during development and inhibition of tumor growth.
- Published
- 2017
112. Femmes de sciences de l’ Antiquité au XIX e siècle. Réalités et représentations, edited by Adeline Gargam
- Author
-
Francesca Antonelli and Antonelli, Francesca
- Subjects
History and Philosophy of Science ,[Recensione] - Abstract
[Recensione]
- Published
- 2017
113. Induction and Repair of DNA DSB as Revealed by H2AX Phosphorylation Foci in Human Fibroblasts Exposed to Low- and High-LET Radiation: Relationship with Early and Delayed Reproductive Cell Death
- Author
-
S. Meschini, Valentina Dini, Giustina Simone, Eugenio Sorrentino, Alessandro Campa, F. Antonelli, G.A.P. Cirrone, Mauro Belli, M. A. Tabocchini, Giuseppe Esposito, P. Giardullo, S. Gerardi, Antonelli, Francesca, Campa, Alessandra, Esposito, G., Giardullo, P., Belli, M., Dini, V., Meschini, S., Simone, G., Sorrentino, Eugenio, Gerardi, S., Cirrone, G. A. P., and Tabocchini, M. A.
- Subjects
Radiology, Nuclear Medicine and Imaging ,Programmed cell death ,Focus (geometry) ,DNA Repair ,DNA repair ,DNA damage ,Biophysics ,Linear energy transfer ,Biology ,medicine.disease_cause ,Cell Line ,Histones ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,DNA Breaks, Double-Stranded ,Linear Energy Transfer ,Phosphorylation ,Kinetic ,Mutation ,Radiation ,Cell Death ,Dose-Response Relationship, Radiation ,Fibroblasts ,Molecular biology ,Histone ,Dose–response relationship ,Kinetics ,Cell killing ,Biophysic ,Fibroblast ,Human - Abstract
The spatial distribution of radiation-induced DNA breaks within the cell nucleus depends on radiation quality in terms of energy deposition pattern. It is generally assumed that the higher the radiation linear energy transfer (LET), the greater the DNA damage complexity. Using a combined experimental and theoretical approach, we examined the phosphorylation-dephosphorylation kinetics of radiation-induced γ-H2AX foci, size distribution and 3D focus morphology, and the relationship between DNA damage and cellular end points (i.e., cell killing and lethal mutations) after exposure to gamma rays, protons, carbon ions and alpha particles. Our results showed that the maximum number of foci are reached 30 min postirradiation for all radiation types. However, the number of foci after 0.5 Gy of each radiation type was different with gamma rays, protons, carbon ions and alpha particles inducing 12.64 ± 0.25, 10.11 ± 0.40, 8.84 ± 0.56 and 4.80 ± 0.35 foci, respectively, which indicated a clear influence of the track structure and fluence on the numbers of foci induced after a dose of 0.5 Gy for each radiation type. The γ-H2AX foci persistence was also dependent on radiation quality, i.e., the higher the LET, the longer the foci persisted in the cell nucleus. The γ-H2AX time course was compared with cell killing and lethal mutation and the results highlighted a correlation between cellular end points and the duration of γ-H2AX foci persistence. A model was developed to evaluate the probability that multiple DSBs reside in the same gamma-ray focus and such probability was found to be negligible for doses lower than 1 Gy. Our model provides evidence that the DSBs inside complex foci, such as those induced by alpha particles, are not processed independently or with the same time constant. The combination of experimental, theoretical and simulation data supports the hypothesis of an interdependent processing of closely associated DSBs, possibly associated with a diminished correct repair capability, which affects cell killing and lethal mutation.
- Published
- 2015
114. From the BCFN’s Double Pyramid to virtual water in the production of pasta Barilla
- Author
-
Luca Ruini, Carlo Alberto Pratesi, Ludovica Principato, Massimo Marino, Sonia Pignatelli, Marta Antonelli, Francesca Greco, Ruini, Luca, Pratesi, Carlo Alberto, Principato, Ludovica, Marino, Massimo, and Pignatelli, Sonia
- Subjects
Engineering (all) ,Agricultural and Biological Sciences (all) - Published
- 2015
115. Botulinum neurotoxin as early treatment in acute-onset lesional hemiballism.
- Author
-
Di Rauso G, Orlandi N, Jacopetti M, Bigliardi G, Antonelli F, Meletti S, and Rispoli V
- Subjects
- Humans, Male, Neuromuscular Agents administration & dosage, Neuromuscular Agents therapeutic use, Botulinum Toxins, Type A administration & dosage, Botulinum Toxins, Type A therapeutic use, Chorea drug therapy, Middle Aged, Dyskinesias drug therapy, Dyskinesias etiology
- Abstract
Background: Hemiballism (HB) and hemichorea (HC) are the most frequent secondary movement disorders, usually caused by cerebrovascular diseases. In only a minority of cases, these involuntary movements are not self-limited, and they may severely compromise patients' quality of life, so that symptomatic treatments are required. Typical and atypical neuroleptics as well as tetrabenazine are considered therapies of choice. However, anecdotal reports of antiseizures medications and botulinum neurotoxin injection effectiveness have been described., Methods: We described a case of severely disabling acute-onset lesional HB/HC, where high dosage of first- and second-line therapies was contraindicated due to patient's comorbidities., Results: After botulin neurotoxin (BoNT) injections in his left upper limb muscles (biceps brachii, triceps brachii, teres major, and deltoid), the patient experienced gradual reduction of hyperkinetic movements. The gradual discontinuation of topiramate (TPM) did not worsen the clinical picture., Discussion: The reduction of hyperkinetic movements led to rhabdomyolysis resolution as well as cutaneous injuries healing with renal function improvement, so that the patient was able to be eligible for rehabilitation, which was prevented by HB/HC itself. The clinical improvement was consistent with BoNT pharmacokinetic. The administration of BoNT early after the onset of lesional HB/HC remarkably modified the clinical management and drove toward comorbidities resolution and rehabilitation., Conclusion: The present case highlights the effectiveness of unconventional therapeutic options in disabling acute onset lesional HB/HC when first-line therapies are contraindicated. Particularly, this report may encourage BoNT application in the early stage of movement disorder emergencies., (© 2024. Fondazione Società Italiana di Neurologia.)
- Published
- 2024
- Full Text
- View/download PDF
116. Comparing the effects of irradiation with protons or photons on neonatal mouse brain: Apoptosis, oncogenesis and hippocampal alterations.
- Author
-
Giovannini D, Antonelli F, Casciati A, De Angelis C, Denise Astorino M, Bazzano G, Fratini E, Ampollini A, Vadrucci M, Cisbani E, Nenzi P, Picardi L, Saran A, Marino C, Mancuso M, Ronsivalle C, and Pazzaglia S
- Subjects
- Animals, Mice, Medulloblastoma radiotherapy, Medulloblastoma pathology, Carcinogenesis radiation effects, Mice, Knockout, Cerebellar Neoplasms radiotherapy, Cerebellar Neoplasms pathology, Brain radiation effects, Patched-1 Receptor genetics, Disease Models, Animal, Protons adverse effects, Apoptosis radiation effects, Proton Therapy adverse effects, Hippocampus radiation effects, Photons, Animals, Newborn
- Abstract
Background and Purpose: Medulloblastoma (MB) is a common primary brain cancer in children. Proton therapy in pediatric MB is intensively studied and widely adopted. Compared to photon, proton radiations offer potential for reduced toxicity due to the characteristic Bragg Peak at the end of their path in tissue. The aim of this study was to compare the effects of irradiation with the same dose of protons or photons in Patched1 heterozygous knockout mice, a murine model predisposed to cancer and non-cancer radiogenic pathologies, including MB and lens opacity., Materials and Methods: TOP-IMPLART is a pulsed linear proton accelerator for proton therapy applications. We compared the long-term health effects of 3 Gy of protons or photons in neonatal mice exposed at postnatal day 2, during a peculiarly susceptible developmental phase of the cerebellum, lens, and hippocampus, to genotoxic stress., Results: Experimental testing of the 5 mm Spread-Out Bragg Peak (SOBP) proton beam, through evaluation of apoptotic response, confirmed that both cerebellum and hippocampus were within the SOBP irradiation field. While no differences in MB induction were observed after irradiation with protons or photons, lens opacity examination confirmed sparing of the lens after proton exposure. Marked differences in expression of neurogenesis-related genes and in neuroinflammation, but not in hippocampal neurogenesis, were observed after irradiation of wild-type mice with both radiation types., Conclusion: In-vivo experiments with radiosensitive mouse models improve our mechanistic understanding of the dependence of brain damage on radiation quality, thus having important implications in translational research., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
117. Role of Apolipoprotein E in the Hippocampus and Its Impact following Ionizing Radiation Exposure.
- Author
-
Casciati A, Pasquali E, De Stefano I, Braga-Tanaka I, Tanaka S, Mancuso M, Antonelli F, and Pazzaglia S
- Subjects
- Animals, Mice, Female, Mice, Inbred C57BL, Neurons metabolism, Neurons radiation effects, Neurogenesis radiation effects, Whole-Body Irradiation, Radiation Exposure adverse effects, Dentate Gyrus metabolism, Dentate Gyrus radiation effects, Dentate Gyrus pathology, Apolipoproteins E metabolism, Apolipoproteins E genetics, Hippocampus metabolism, Hippocampus radiation effects, Radiation, Ionizing, MicroRNAs metabolism, MicroRNAs genetics
- Abstract
Apolipoprotein E (ApoE) is a lipid carrier in both the peripheral and the central nervous systems (CNSs). Lipid-loaded ApoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and brain injury repair. In the brain, ApoE is produced predominantly by astrocytes, but it is also abundantly expressed in most neurons of the CNS. In this study, we addressed the role of ApoE in the hippocampus in mice, focusing on its role in response to radiation injury. To this aim, 8-week-old, wild-type, and ApoE-deficient (ApoE
-/- ) female mice were acutely whole-body irradiated with 3 Gy of X-rays (0.89 Gy/min), then sacrificed 150 days post-irradiation. In addition, age-matching ApoE-/- females were chronically whole-body irradiated (20 mGy/d, cumulative dose of 3 Gy) for 150 days at the low dose-rate facility at the Institute of Environmental Sciences (IES), Rokkasho, Japan. To seek for ApoE-dependent modification during lineage progression from neural stem cells to neurons, we have evaluated the cellular composition of the dentate gyrus in unexposed and irradiated mice using stage-specific markers of adult neurogenesis. Our findings indicate that ApoE genetic inactivation markedly perturbs adult hippocampal neurogenesis in unexposed and irradiated mice. The effect of ApoE inactivation on the expression of a panel of miRNAs with an established role in hippocampal neurogenesis, as well as its transcriptional consequences in their target genes regulating neurogenic program, have also been analyzed. Our data show that the absence of ApoE-/- also influences synaptic functionality and integration by interfering with the regulation of mir-34a, mir-29b, and mir-128b, leading to the downregulation of synaptic markers PSD95 and synaptophysin mRNA. Finally, compared to acute irradiation, chronic exposure of ApoE null mice yields fewer consequences except for the increased microglia-mediated neuroinflammation. Exploring the function of ApoE in the hippocampus could have implications for developing therapeutic approaches to alleviate radiation-induced brain injury.- Published
- 2024
- Full Text
- View/download PDF
118. Involvement of Mitochondria in the Selective Response to Microsecond Pulsed Electric Fields on Healthy and Cancer Stem Cells in the Brain.
- Author
-
Casciati A, Taddei AR, Rampazzo E, Persano L, Viola G, Cani A, Bresolin S, Cesi V, Antonelli F, Mancuso M, Merla C, and Tanori M
- Subjects
- Cell Membrane metabolism, Electricity, Cytoskeleton metabolism, Brain metabolism, Mitochondria metabolism, Neoplasms metabolism
- Abstract
In the last few years, pulsed electric fields have emerged as promising clinical tools for tumor treatments. This study highlights the distinct impact of a specific pulsed electric field protocol, PEF-5 (0.3 MV/m, 40 μs, 5 pulses), on astrocytes (NHA) and medulloblastoma (D283) and glioblastoma (U87 NS) cancer stem-like cells (CSCs). We pursued this goal by performing ultrastructural analyses corroborated by molecular/omics approaches to understand the vulnerability or resistance mechanisms triggered by PEF-5 exposure in the different cell types. Electron microscopic analyses showed that, independently of exposed cells, the main targets of PEF-5 were the cell membrane and the cytoskeleton, causing membrane filopodium-like protrusion disappearance on the cell surface, here observed for the first time, accompanied by rapid cell swelling. PEF-5 induced different modifications in cell mitochondria. A complete mitochondrial dysfunction was demonstrated in D283, while a mild or negligible perturbation was observed in mitochondria of U87 NS cells and NHAs, respectively, not sufficient to impair their cell functions. Altogether, these results suggest the possibility of using PEF-based technology as a novel strategy to target selectively mitochondria of brain CSCs, preserving healthy cells.
- Published
- 2024
- Full Text
- View/download PDF
119. Long-term effects of bilateral subthalamic nucleus deep brain stimulation on gait disorders in Parkinson's disease: a clinical-instrumental study.
- Author
-
Cavallieri F, Campanini I, Gessani A, Budriesi C, Fioravanti V, Di Rauso G, Feletti A, Damiano B, Scaltriti S, Guagnano N, Bardi E, Corni MG, Rossi J, Antonelli F, Cavalleri F, Molinari MA, Contardi S, Menozzi E, Puzzolante A, Vannozzi G, Bergamini E, Pavesi G, Meoni S, Fraix V, Fraternali A, Versari A, Lusuardi M, Biagini G, Merlo A, Moro E, and Valzania F
- Subjects
- Male, Humans, Middle Aged, Postural Balance, Treatment Outcome, Time and Motion Studies, Gait, Parkinson Disease therapy, Parkinson Disease drug therapy, Subthalamic Nucleus physiology, Deep Brain Stimulation methods
- Abstract
Objective: To assess the long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on gait in a cohort of advanced Parkinson's Disease (PD) patients., Methods: This observational study included consecutive PD patients treated with bilateral STN-DBS. Different stimulation and drug treatment conditions were assessed: on-stimulation/off-medication, off-stimulation/off-medication, and on-stimulation/on-medication. Each patient performed the instrumented Timed Up and Go test (iTUG). The instrumental evaluation of walking ability was carried out with a wearable inertial sensor containing a three-dimensional (3D) accelerometer, gyroscope, and magnetometer. This device could provide 3D linear acceleration, angular velocity, and magnetic field vector. Disease motor severity was evaluated with the total score and subscores of the Unified Parkinson Disease Rating Scale part III., Results: Twenty-five PD patients with a 5-years median follow-up after surgery (range 3-7) were included (18 men; mean disease duration at surgery 10.44 ± 4.62 years; mean age at surgery 58.40 ± 5.73 years). Both stimulation and medication reduced the total duration of the iTUG and most of its different phases, suggesting a long-term beneficial effect on gait after surgery. However, comparing the two treatments, dopaminergic therapy had a more marked effect in all test phases. STN-DBS alone reduced total iTUG duration, sit-to-stand, and second turn phases duration, while it had a lower effect on stand-to-sit, first turn, forward walking, and walking backward phases duration., Conclusions: This study highlighted that in the long-term after surgery, STN-DBS may contribute to gait and postural control improvement when used together with dopamine replacement therapy, which still shows a substantial beneficial effect., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
- Published
- 2023
- Full Text
- View/download PDF
120. Author Correction: Long-term effects of subthalamic nucleus deep brain stimulation on speech in Parkinson's disease.
- Author
-
Gessani A, Cavallieri F, Fioravanti V, Campanini I, Merlo A, Di Rauso G, Damiano B, Scaltriti S, Bardi E, Corni MG, Antonelli F, Cavalleri F, Molinari MA, Contardi S, Menozzi E, Fraternali A, Versari A, Biagini G, Fraix V, Pinto S, Moro E, Budriesi C, and Valzania F
- Published
- 2023
- Full Text
- View/download PDF
121. Long-term effects of subthalamic nucleus deep brain stimulation on speech in Parkinson's disease.
- Author
-
Gessani A, Cavallieri F, Fioravanti V, Campanini I, Merlo A, Di Rauso G, Damiano B, Scaltriti S, Bardi E, Corni MG, Antonelli F, Cavalleri F, Molinari MA, Contardi S, Menozzi E, Fraternali A, Versari A, Biagini G, Fraix V, Pinto S, Moro E, Budriesi C, and Valzania F
- Subjects
- Humans, Treatment Outcome, Speech Intelligibility physiology, Parkinson Disease surgery, Subthalamic Nucleus, Deep Brain Stimulation methods
- Abstract
Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment in advanced Parkinson's Disease (PD). However, the effects of STN-DBS on speech are still debated, particularly in the long-term follow-up. The objective of this study was to evaluate the long-term effects of bilateral STN-DBS on speech in a cohort of advanced PD patients treated with bilateral STN-DBS. Each patient was assessed before surgery through a neurological evaluation and a perceptual-acoustic analysis of speech and re-assessed in the long-term in different stimulation and drug conditions. The primary outcome was the percentage change of speech intelligibility obtained by comparing the postoperative on-stimulation/off-medication condition with the preoperative off-medication condition. Twenty-five PD patients treated with bilateral STN-DBS with a 5-year follow-up were included. In the long-term, speech intelligibility stayed at the same level as preoperative values when compared with preoperative values. STN-DBS induced a significant acute improvement of speech intelligibility (p < 0.005) in the postoperative assessment when compared to the on-stimulation/off-medication and off-stimulation/off-medication conditions. These results highlight that STN-DBS may handle speech intelligibility even in the long-term., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
122. Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus.
- Author
-
Antonelli F, Casciati A, and Pazzaglia S
- Abstract
Competing Interests: None
- Published
- 2019
- Full Text
- View/download PDF
123. Reply: To PMID 24243538.
- Author
-
Serra J, Collado A, Solà R, Antonelli F, Torres X, Salgueiro M, Quiles C, and Bostock H
- Subjects
- Female, Humans, Fibromyalgia pathology, Fibromyalgia physiopathology, Nerve Fibers, Unmyelinated physiology, Nociceptors pathology
- Published
- 2014
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.