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101. Prospects of polarized fixed target Drell-Yan experiments

Author

Liu, Ming X., Jiang, Xiaodong, Crabb, Donald G., Chen, Jian-ping, and Bai, Mei

Subjects
Nuclear Experiment
Abstract

It has been proposed that the Siverse transverse single spin asymmetry in Drell-Yan production in transversely polarized p+p collisions would have an opposite sign compared to what has been observed in the polarized Semi-Inclusive Deep Inelastic Scattering (SIDIS) experiments. Experimental confirmation or disproval of this prediction would provide a new fundamental test of QCD and shed new light on our theoretical understanding of the transverse spin physics phenomena. We discuss the prospects and physics sensitivities of polarized fixed target Drell-Yan experiments that could utilize the existing proton and other hadron beams at Fermilab, and polarized proton beams at RHIC with a polarized solid proton and/or neutron target option. We show that if realized, the new experiments would provide critical measurements of not only the sign change (or not) of Sivers functions, but also the information of quark and antiquark's Sivers distributions over a wide kinematic range., Comment: 8 pages, to appear in the proceedings of the 19th International Spin Physics Symposium (SPIN 2010), Julich, Germany, Sep 27- Oct 2, 2010

Published
2010
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103. Contribution of ADD3 and the HLA Genes to Biliary Atresia Risk in Chinese

Author

Cui, Meng-Meng, primary, Gong, Yi-Ming, additional, Pan, Wei-Hua, additional, Pei, Hao-Yue, additional, Bai, Mei-Rong, additional, Song, Huan-Lei, additional, Han, Xin-Ru, additional, Wu, Wen-Jie, additional, Yu, Wen-Wen, additional, Gu, Bei-Lin, additional, Cai, Wei, additional, Zhou, Ying, additional, and Chu, Xun, additional

Published
2023
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105. Status and future plans for C3 R&D

Author

Nanni, Emilio A., primary, Breidenbach, Martin, additional, Li, Zenghai, additional, Vernieri, Caterina, additional, Wang, Faya, additional, White, Glen, additional, Bai, Mei, additional, Belomestnykh, Sergey, additional, Bhat, Pushpalatha, additional, Barklow, Tim, additional, Berg, William J., additional, Borzenets, Valery, additional, Byrd, John, additional, Dhar, Ankur, additional, Dhuley, Ram C., additional, Doss, Chris, additional, Duris, Joseph, additional, Edelen, Auralee, additional, Emma, Claudio, additional, Frisch, Josef, additional, Gabriel, Annika, additional, Gessner, Spencer, additional, Hast, Carsten, additional, Jing, Chunguang, additional, Klebaner, Arkadiy, additional, Kim, Dongsung, additional, Krasnykh, Anatoly K., additional, Lewellen, John, additional, Liepe, Matthias, additional, Litos, Michael, additional, Lu, Xueying, additional, Maxson, Jared, additional, Montanari, David, additional, Musumeci, Pietro, additional, Nagaitsev, Sergei, additional, Nassiri, Alireza, additional, Ng, Cho-Kuen, additional, Othman, Mohamed A.K., additional, Oriunno, Marco, additional, Palmer, Dennis, additional, Patterson, J. Ritchie, additional, Peskin, Michael E., additional, Peterson, Thomas J., additional, Power, John, additional, Qiang, Ji, additional, Rosenzweig, James, additional, Shiltsev, Vladimir, additional, Shumail, Muhammad, additional, Simakov, Evgenya, additional, Snively, Emma, additional, Spataro, Bruno, additional, Tantawi, Sami, additional, van der Graaf, Harry, additional, Weatherford, Brandon, additional, Wu, Juhao, additional, and Wootton, Kent P., additional

Published
2023
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106. Circular RNA screening from EIF3a in lung cancer

Author

Ma‐Sha Huang, Fu‐Qiang Yuan, Yang Gao, Jun‐Yan Liu, Yi‐Xin Chen, Chen‐Jing Wang, Bai‐Mei He, Hong‐Hao Zhou, and Zhao‐Qian Liu

Subjects
bioinformatics, circular RNA, EIF3a, lung cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Eukaryotic initiation factor 3 (EIF3) is one of the largest and most complex translation initiation factors, which consists of 13 subunits named eukaryotic translation initiation factor 3 subunit A (EIF3a) to EIF3m. EIF3a is the largest subunit of EIF3. Previous studies suggested that EIF3a is a housekeeping gene, recent results have found that EIF3a is closely related to the tumorigenesis and drug resistance. Circular RNAs (circRNAs) derived from biologically important gene can play an important role in gene regulation. However, the mechanism underlying circRNAs’ biological functions is not well understood yet. In this work, we screened 31 EIF3a‐derived circRNAs, in which two circEIF3as were identified to be correlated with cisplatin drug sensitivity in lung cancer. Two circEIF3as were found involved in RNA‐binding proteins‐mediated biological processes and may be related to translational regulation according to bioinformatics analyses. CircEIF3as, the transcriptional initiation factor EIF3a transcribed circRNAs, are associated with both drug sensitivity and translation regulation. These findings mean that they may have a functional synergy effect with EIF3a or be valuable therapeutic targets for treatment like EIF3a. This is the first study that exploits circRNAs screening from EIF3a in lung cancer, our findings provide a novel perspective on the function of EIF3a and circEIF3as in lung cancer.

Published
2019
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116. Two band gap field-dependent thermal conductivity of $MgB_2$

Author

Wu, Bai-Mei, Yang, Dong-Sheng, Zeng, Wei-Hua, Li, Shi-Yan, Li, Bo, Fan, Rong, Chen, Xian-Hui, Cao, Lie-Zhao, and Ausloos, Marcel

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science
Abstract

The thermal conductivity $\kappa (H,T)$ of the new superconductor $MgB_2$ was studied as a function of the temperature and a magnetic field. No anomaly in the thermal conductivity $\kappa (H,T)$ is observed around the superconducting transition in absence or presence of magnetic fields up to 14 Tesla; upon that field the superconductivity of $MgB_2$ persisted. The thermal conductivity in zero-field shows a $T$-linear increase up to 50K. The thermal conductivity is found to increase with increasing field at high fields. We interpret the findings as if there are two subsystems of quasiparticles with different field-dependent characters in a two ($L$ and $S$)-band superconductor reacting differently with the vortex structure. The unusual enhancement of $\kappa (H ,T)$ at low temperature but higher than a ($H_{c2S}\simeq 3T$) critical field is interpreted as a result of the overlap of the low energy states outside the vortex cores in the $S$-band., Comment: 6 pages,3 figures

Published
2003
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123. Inhibition of Serum- and Glucocorticoid-Regulated Protein Kinase-1 Aggravates Imiquimod-Induced Psoriatic Dermatitis and Enhances Proinflammatory Cytokine Expression through the NF-kB Pathway

Author

Meng, Qinqin, primary, Bai, Mei, additional, Guo, Meiliang, additional, Li, Zhengxiao, additional, Liu, Wanwen, additional, Fan, Xiaojing, additional, Sun, Rui, additional, Yang, Xinrong, additional, Yuan, Dingfen, additional, Shi, Yuling, additional, and Deng, Hui, additional

Published
2023
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129. Ca2+- and Zn2+-dependent nucleases co-participate in nuclear DNA degradation during programmed cell death in secretory cavity development in Citrus fruits.

Author

Liang, Minjian, Huai, Bin, Lin, Junjun, Liang, Xiangxiu, He, Hanjun, Bai, Mei, and Wu, Hong

Subjects
NUCLEAR DNA, APOPTOSIS, CITRUS fruits, NUCLEASES, MANDARIN orange, ZINC-finger proteins
Abstract

Calcium (Ca2+)- and zinc Zn2+-dependent nucleases play pivotal roles in plant nuclear DNA degradation in programmed cell death (PCD). However, the mechanisms by which these two nucleases co-participate in PCD-associated nuclear DNA degradation remain unclear. Here, the spatiotemporal expression patterns of two nucleases (CrCAN and CrENDO1) were analyzed qualitatively and quantitatively during PCD in secretory cavity formation in Citrus reticulata 'Chachi' fruits. Results show that the middle and late initial cell stages and lumen-forming stages are key stages for nuclear degradation during the secretory cavity development. CAN and ENDO1 exhibited potent in vitro DNA degradation activity at pH 8.0 and pH 5.5, respectively. Quantitative real-time reverse-transcription polymerase chain reaction, in situ hybridization assays, the subcellular localization of Ca2+ and Zn2+, and immunocytochemical localization showed that CrCAN was activated at the middle and late initial cell stages, while CrENDO1 was activated at the late initial cell and lumen-forming stages. Furthermore, we used immunocytochemical double-labelling to simultaneously locate CrCAN and CrENDO1. The DNA degradation activity of the two nucleases was verified by simulating the change of intracellular pH in vitro. Our results also showed that CrCAN and CrENDO1 worked respectively and co-participated in nuclear DNA degradation during PCD of secretory cavity cells. In conclusion, we propose the model for the synergistic effect of Ca2+- and Zn2+-dependent nucleases (CrCAN and CrENDO1) in co-participating in nuclear DNA degradation during secretory cavity cell PCD in Citrus fruits. Our findings provide direct experimental evidence for exploring different ion-dependent nucleases involved in nuclear degradation during plant PCD. [ABSTRACT FROM AUTHOR]

Published
2024
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136. Data from Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells

Author

Chang, De-Kuan, primary, Sui, Jianhua, primary, Geng, Shusheng, primary, Muvaffak, Asli, primary, Bai, Mei, primary, Fuhlbrigge, Robert C., primary, Lo, Agnes, primary, Yammanuru, Anuradha, primary, Hubbard, Luke, primary, Sheehan, Jared, primary, Campbell, James J., primary, Zhu, Quan, primary, Kupper, Thomas S., primary, and Marasco, Wayne A., primary

Published
2023
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137. Supplementary Figure 5 from Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells

Author

Chang, De-Kuan, primary, Sui, Jianhua, primary, Geng, Shusheng, primary, Muvaffak, Asli, primary, Bai, Mei, primary, Fuhlbrigge, Robert C., primary, Lo, Agnes, primary, Yammanuru, Anuradha, primary, Hubbard, Luke, primary, Sheehan, Jared, primary, Campbell, James J., primary, Zhu, Quan, primary, Kupper, Thomas S., primary, and Marasco, Wayne A., primary

Published
2023
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138. Supplementary Methods from Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells

Author

Chang, De-Kuan, primary, Sui, Jianhua, primary, Geng, Shusheng, primary, Muvaffak, Asli, primary, Bai, Mei, primary, Fuhlbrigge, Robert C., primary, Lo, Agnes, primary, Yammanuru, Anuradha, primary, Hubbard, Luke, primary, Sheehan, Jared, primary, Campbell, James J., primary, Zhu, Quan, primary, Kupper, Thomas S., primary, and Marasco, Wayne A., primary

Published
2023
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139. Supplementary Figure 1 from Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells

Author

Chang, De-Kuan, primary, Sui, Jianhua, primary, Geng, Shusheng, primary, Muvaffak, Asli, primary, Bai, Mei, primary, Fuhlbrigge, Robert C., primary, Lo, Agnes, primary, Yammanuru, Anuradha, primary, Hubbard, Luke, primary, Sheehan, Jared, primary, Campbell, James J., primary, Zhu, Quan, primary, Kupper, Thomas S., primary, and Marasco, Wayne A., primary

Published
2023
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140. Supplementary Figure 4 from Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells

Author

Chang, De-Kuan, primary, Sui, Jianhua, primary, Geng, Shusheng, primary, Muvaffak, Asli, primary, Bai, Mei, primary, Fuhlbrigge, Robert C., primary, Lo, Agnes, primary, Yammanuru, Anuradha, primary, Hubbard, Luke, primary, Sheehan, Jared, primary, Campbell, James J., primary, Zhu, Quan, primary, Kupper, Thomas S., primary, and Marasco, Wayne A., primary

Published
2023
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141. Supplementary Figure 2 from Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells

Author

Chang, De-Kuan, primary, Sui, Jianhua, primary, Geng, Shusheng, primary, Muvaffak, Asli, primary, Bai, Mei, primary, Fuhlbrigge, Robert C., primary, Lo, Agnes, primary, Yammanuru, Anuradha, primary, Hubbard, Luke, primary, Sheehan, Jared, primary, Campbell, James J., primary, Zhu, Quan, primary, Kupper, Thomas S., primary, and Marasco, Wayne A., primary

Published
2023
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142. Supplementary Figure Legend from Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells

Author

Chang, De-Kuan, primary, Sui, Jianhua, primary, Geng, Shusheng, primary, Muvaffak, Asli, primary, Bai, Mei, primary, Fuhlbrigge, Robert C., primary, Lo, Agnes, primary, Yammanuru, Anuradha, primary, Hubbard, Luke, primary, Sheehan, Jared, primary, Campbell, James J., primary, Zhu, Quan, primary, Kupper, Thomas S., primary, and Marasco, Wayne A., primary

Published
2023
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143. Supplementary Figure 3 from Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells

Author

Chang, De-Kuan, primary, Sui, Jianhua, primary, Geng, Shusheng, primary, Muvaffak, Asli, primary, Bai, Mei, primary, Fuhlbrigge, Robert C., primary, Lo, Agnes, primary, Yammanuru, Anuradha, primary, Hubbard, Luke, primary, Sheehan, Jared, primary, Campbell, James J., primary, Zhu, Quan, primary, Kupper, Thomas S., primary, and Marasco, Wayne A., primary

Published
2023
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148. Successful treatment of a severe Takotsubo syndrome case complicated by liver abscess

Author

Zhi-Yue Zhang, Jin-Jin Sun, Jun-Hua Wang, Peng Wang, Bai-Mei Liu, Jun-Hua Xing, Jun Liu, Da-Peng Zhang, Zhen-Zhen Kong, Hai-Tao Zhang, and Xin-Ya Yu

Subjects
Cardiology and Cardiovascular Medicine
Abstract

The main manifestations of Takotsubo syndrome (TTS) are a spherical expansion of the left ventricle or near the apex and decreased systolic function. TTS is mostly thought to be induced by emotional stress, and the induction of TTS by severe infection is not often reported. A 72-year-old female patient with liver abscess reported herein was admitted due to repeated fever with a history of hypertension and impaired glucose tolerance. Her severe infection caused TTS, and her blood pressure dropped to 80/40 mmHg. IABP treatment was performed immediately and continued for 10 days, and comprehensive medication was administered. Based on her disease course and her smooth recovery, general insights and learnings may be: Adding to mental and other pathological stress reaction, serious infections from pathogenic microorganism could be of great important causation of stress reaction leading to TTS, while basic diseases such as coronary heart disease, hypertension, and diabetes were be of promoting factors; In addition to effective drug therapies for TTS, the importance of the timely using of IABP should be emphasized.

Published
2023

149. Application of a JEG-3 organoid model to study HLA-G function in the trophoblast

Author

Bai-Mei Zhuang, Dan-Dan Cao, Xiao-Feng Liu, Li Wang, Xiao-Li Lin, Yong-Gang Duan, Cheuk-Lun Lee, Philip C. N. Chiu, William S. B. Yeung, and Yuan-Qing Yao

Subjects
Immunology, Immunology and Allergy
Abstract

The human placenta is a unique temporary organ with a mysterious immune tolerance. The formation of trophoblast organoids has advanced the study of placental development. HLA-G is uniquely expressed in the extravillous trophoblast (EVT) and has been linked to placental disorders. With older experimental methodologies, the role of HLA-G in trophoblast function beyond immunomodulation is still contested, as is its role during trophoblast differentiation. Organoid models incorporating CRISPR/Cas9 technology were used to examine the role of HLA-G in trophoblast function and differentiation. JEG-3 trophoblast organoids (JEG-3-ORGs) were established that highly expressed trophoblast representative markers and had the capacity to differentiate into EVT. CRISPR/Cas9 based on HLA-G knockout (KO) significantly altered the trophoblast immunomodulatory effect on the cytotoxicity of natural killer cells, as well as the trophoblast regulatory effect on HUVEC angiogenesis, but had no effect on the proliferation and invasion of JEG-3 cells and the formation of TB-ORGs. RNA-sequencing analysis further demonstrated that JEG-3 KO cells followed similar biological pathways as their wild-type counterparts during the formation of TB-ORGs. In addition, neither HLA-G KO nor the exogenous addition of HLA-G protein during EVT differentiation from JEG-3-ORGs altered the temporal expression of the known EVT marker genes. Based on the JEG-3 KO (disruption of exons 2 and 3) cell line and the TB-ORGs model, it was determined that HLA-G has a negligible effect on trophoblast invasion and differentiation. Despite this, JEG-3-ORG remains a valuable model for studying trophoblast differentiation.

Published
2023

150. Density-Based Local Outlier Detection on Uncertain Data

Author

Cao, Keyan, Shi, Lingxu, Wang, Guoren, Han, Donghong, Bai, Mei, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Kobsa, Alfred, editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Weikum, Gerhard, editor, Li, Feifei, editor, Li, Guoliang, editor, Hwang, Seung-won, editor, Yao, Bin, editor, and Zhang, Zhenjie, editor

Published
2014
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