Search

[ES] Introducción y Justificación del estudio: El neuroblastoma (NB) es el tumor sólido extracraneal más frecuente en la infancia y causa alrededor del 15% de las muertes oncológicas en la edad pediátrica. Es un tumor embrionario que deriva del sistema nervioso simpático y que se caracteriza por ser tremendamente heterogéneo en su presentación clínica, morfológica y genética. De hecho, actualmente el Grupo Internacional de riesgo de neuroblastoma (INRG, International Neuroblastoma Risk Group) establece cuatro grandes grupos de estratificación de riesgo pre-tratamiento (muy bajo, bajo, intermedio y alto) atendiendo a factores clínicos, histopatológicos y genéticos. Estos grupos se relacionan con la supervivencia a 5 años y determinan el tratamiento a seguir. Los estudios genómicos en los tumores neuroblásticos han identificado características biológicas específicas de la patogénesis del NB útiles en el desarrollo de nuevas estrategias terapéuticas. No obstante, la supervivencia de los pacientes de alto riesgo es menor del 50%. Además, los intensos ciclos de quimioterapia y radioterapia conllevan muchos efectos secundarios que merman la calidad de vida del paciente y que tienen un efecto en el desarrollo del paciente adulto. A nivel genético, en NB la progresión de la enfermedad está determinada por la presencia de alteraciones en el número de copias, que son amplificaciones génicas y ganancias o pérdidas de fragmentos de cromosomas (segmentarias, segmental chromosomal alterations: SCA) o de cromosomas enteros (numéricas, numerical chromosomal alterations: NCA). El uso de técnicas pangenómicas, como los arrays CGH y actualmente los arrays de SNP, ha permitido definir distintos perfiles genómicos asociados con diferentes presentaciones clínicas y progresión de la enfermedad. Así, los tumores con un perfil exclusivamente de NCA se suelen encontrar en niños de menor edad con estadios localizados y que tienen un buen pronóstico, mientras que los tumores con SCA suelen encontrarse en niños de mayor edad en estadios avanzados y que tienen peor pronóstico. Se han descrito SCA más frecuentes y con mayor valor pronóstico, que son deleciones en las regiones 1p, 3p, 4p y 11q y ganancias en 1q, 2p y 17q y la amplificación del gen MYCN. Existen otras alteraciones, aunque menos frecuentes, relacionadas con el grupo de alto riesgo en genes como ALK, ATRX y TERT. Por lo tanto, aunque el conocimiento y aplicación de los cambios genéticos es amplio, es evidente que se requiere seguir realizando estudios genéticos para detectar nuevos factores que mejoren la clasificación de riesgo. Hipótesis: Con los antecedentes mencionados nos planteamos que a la enfermedad neuroblástica puede estar contribuyendo no sólo los tipos cromosómicos específicos de alteraciones en el número de copias, sino también las cantidades de material genético ganado o perdido implicados en dichas alteraciones. Objetivo general: Determinar si la cantidad de material genético neta resultante de las SCA permite identificar distintos subgrupos genéticos dentro del grupo de NB de alto riesgo en una cohorte de más de 100 pacientes de alto riesgo. El fin último de este trabajo es evaluar la posible contribución de la cantidad de material genético alterado en el grupo de alto riesgo y su posible validación en una cohorte mayor para trasladar su uso en la estratificación terapéutica. Métodos: Se analizarán los perfiles obtenidos con distintas plataformas de arrays de polimorfismo de nucleótido único (SNP) y se cuantificará la cantidad de material genético ganado y perdido (expresada en kb) en un grupo de tumores primarios de alto riesgo de NB con diferentes perfiles de variaciones en el número de copias., [EN] Background and rationale: Neuroblastoma (NB) is the most common extracranial solid tumour in infants and causes about 15% of all pediatric oncology deaths. It is an embrionary tumour derived from the sympathetic nervous system and characterized by being highly heterogeneous in its clinical, morfological and genetic presentation. In fact, the International Neuroblastoma Risk Group (INRG) currently establishes four main pretreatment risk stratification groups (very low, low, intermediate and high) according to clinical, histopathological and genetic factors. These groups correlate with 5-year event-free survival rates and determine treatment decision. Genomic studies in neuroblastic tumours have revealed specific biologic characteristics useful for new therapy development. Nevertheless, patient survival within the high-risk group is lower than 50%. Besides, intensive cycles of chemo- and radiotherapy involve many secondary effects that diminish the quality of life and that impact growth and development of the pediatric patient. Concerning genetics, NB progression is determined by the presence of copy number alterations, that are amplifications, gains or losses of either chromosome fragments (segmental chromosomal alterations: SCA) or entire chromosomes (numerical chromosomal alterations: NCA). The use of pangenomic techniques, such as Comparative Genomic Hybridization arrays and currently Single Nucleotide Polymorphism array (SNP array), has allowed us to define diverse genomic profiles associated with different clinical presentations. Thus, tumors with an exclusively NCA profile are frequently observed in younger children with localized disease and good outcome, while tumors with SCA frequently belong to older children with advanced stages of disease and poorer outcome. Several SCA have been associated with prognostic impact in NB, these are 1p, 3p, 4p and 11q deletions and 1q, 2p and 17 gains, as well as MYCN amplification. Other alterations, although less frequent, have been related to the high-risk group in ALK, ATRX and TERT. Thus, although the knowledge and application of these genomic changes are wide, it is evident that other genetic studies are necessary to detect new factors that improve risk classification. Hypothesis: We hypothesized that not only the specific chromosomic copy number alterations contribute to neuroblastic disease but also the amount of gained and lost genetic material implicated in these alterations. General objective: To determine if net genetic material resulting from SCAs allows to identify distinct genetic subgroups within NB high-risk group in a cohort of more than 100 high-risk patients. The final objective is to evaluate the contribution of the amount of altered genetic material to NB high-risk disease and its possible validation in a higher cohort to be included as a stratifying therapeutic variable. Methods: Tumor genetic profiles obtained with distinct SNP array platforms will be analyzed and amount of gained and lost genetic material (measured in kb) will be quantified in a group of high-risk primary NB tumours with different copy number alterations profiles.

Resumen del póster presentado al European Developmental Biology Congress (EDBC), celebrado en Alicante del 23 al 26 de octubre de 2019., Rubinstein-Taybi syndrome (RSTS) is a genetic neurodevelopmental disorder characterized by mental impairment and a wide spectrum of congenital abnormalities, that is caused by hemizygous mutations in the genes encoding the KAT3 family of transcriptional coactivator CREB binding protein (CBP) and the E1A binding protein P300 (p300). Both factors have intrinsic lysine acetyltransferase (KAT) activity and are critically involved in the transcriptional and epigenetic regulation of gene expression. Consistent with this central role, both CBP and p300 knockout (KO) mice exhibit early embryonic death and neuronal tube closure defects. However, the precise function of these proteins during the development of the central nervous system has not been clearly stated. Here we assess whether KAT3 proteins are necessary for proliferation and neuronal differentiation that could explain some of the neurological alterations associated with RSTS. Experiments performed with neurospheres demonstrate that cell proliferation is normal in the absence of CBP or P300 but it is affected in the absence of both acetyltransferases. However, neuronal differentiation is seriously compromised in neurospheres lacking any of the two proteins. In vivo, CBP deletion in progenitors have a negative impact in the number of differentiated retinal neutrons in contrast to the lack of P300 that has not an impact in the number of neurons. CBP and P300 deletion in differentiated retinal neurons (using Brn3b-Cre line) demonstrate that CBP and P300 are not essential for neuronal viability or identity but these processes are affected when both proteins are eliminated. Ongoing sequencing experiments should further clarify the role of KAT3 proteins in neural differentiation and reveal the redundancy between these two paralog transcriptional coactivators.

RESUMEN: El incremento de la supervivencia y la esperanza de vida ha originado un aumento de la prevalencia de enfermedades crónicas en edades avanzadas. La demencia aún no recibe la prioridad que se merece, a pesar de que se conciba como la primera causa de discapacidad en adultos mayores y la enfermedad que genera mayor dependencia y sobrecarga tanto económica como del cuidador. El objetivo del presente trabajo de revisión fue definir el concepto de estimulación multisensorial en demencias moderadas-­‐avanzadas centrado en la intervención enfermera. Para ello, se realizó una búsqueda bibliográfica en las principales bases de datos de aquellas publicaciones con antigüedad no mayor a cinco años. Tras el análisis posterior de la bibliografía consultada, se puede afirmar que hoy por hoy, no existe tratamiento curativo para esta enfermedad. Sin embargo, las intervenciones no farmacológicas desde el rol del profesional de enfermería, están ocupando un primer plano a la hora de abarcar los síntomas conductuales, haciendo mención especial a la terapia Snoezelen o estimulación multisensorial (EMS). La finalidad de esta modalidad terapeútica es establecer una interacción entre la persona, la tarea y el entorno por medio de la activación de los diferentes sentidos primarios que ofrecen experiencias sensoriales dentro de una atmósfera de tranquilidad y relajación. ABSTRACT: An increase in the survival and longevity of species has led to an increase in the prevalence of chronic diseases in old ages. Dementia still does not receive the priority it deserves even though it is conceived as the first cause of disability in elderly people and the disease that generates greater dependency and economic overload. The objective of the present review was to define the concept of multisensory stimulation in advanced dementias focused on the nursing intervention. A bibliographic search was carried out in the main databases of those publications with an age not exceeding five years in order to do this. After the subsequent analysis of the consulted bibliography it can be affirmed that at this moment, there is no curative treatment for this disease. However, non-­‐pharmacological interventions given from the nursing role, occupy a leading role in the study of behavioral symptoms, with great emphasis in Snoezelen therapy or multisensory stimulation (EMS). The purpose of this therapy is to create an interaction between the person, his main goal and the environment by activating the different primary senses that provide sensory experiences within an atmosphere of trust and relaxation. Grado en Enfermería

This article belongs to the Special Issue Selected Papers from NUTRIMAD 2018. Diet-related risk factors and physical inactivity are among the leading risk factors for disability and are responsible for a large proportion of the burden of chronic non-communicable diseases. Food-based dietary guidelines (FBDGs) are useful tools for nutrition policies and public health strategies to promote healthier eating and physical activity. In this paper, we discuss the process followed in developing the dietary guidelines for the Spanish population by the Spanish Society of Community Nutrition (SENC) and further explain the collaboration with primary healthcare practitioners as presented in the context of the NUTRIMAD 2018 international congress of SENC. From a health in all policies approach, SENC convened a group of experts in nutrition and public health to review the evidence on diet-health, nutrient intake and food consumption in the Spanish population, as well as food preparation, determinants and impact of diet on environmental sustainability. The collaborative group drafted the document and designed the graphic icon, which was then subject to a consultation process, discussion, and qualitative evaluation. Next, a collaborative group was established to plan a dissemination strategy, involving delegates from all the primary healthcare scientific societies in Spain. A product of this collaboration was the release of an attractive, easy-to-understand publication.

Resumen del póster presentado al 3rd AXON Meeting: “Circuits Development & Axon Regeneration”, celebrado en Alicante (España) del 11 al 13 de septiembre de 2019., During development, changes in the genomic profiles of histone acetylation accompany the onset and maintenance of the gene expression programs associated with neuronal differentiation and the formation of neuronal circuits. The paralog lysine acetyltransferases (KAT) CREB binding protein (CBP) and E1A binding protein (p300) are both essential for the normal development of the nervous system. In fact, KAT3 deficiency causes Rubinstein-Taybi syndrome (RSTS), a neurodevelopmental disorder characterized by abnormal brain development, ocular anomalies, intellectual disability and other symptoms. The precise function of these chromatin-modifying enzymes during the development of the central nervous system has not been clearly stated. Here, throughout a combination of in vitro and in vivo approaches and the use of different credrivers, we dissect the functions of CBP and p300 in different steps of neural development. We first demonstrate that the proliferation of neural progenitors in vitro is not affected in the loss of CBP or p300 but is seriously comprised when both proteins are absent. In addition, we observe that the elimination of either CBP or p300 disrupts early neuronal differentiation in vitro, although only CBP seems to be required for terminal retinal cells differentiation in vivo. Similarly to our observations in neuroprogenitors, the maintenance of RGC identity does not individually require either one of the KAT3 proteins, but at least one of the two proteins must be expressed for their preservation. Together these results identify unique and shared roles for these two important epigenetic factors throughout development and demonstrate that CBP plays a more prominent role than p300 during neuronal differentiation in the retina.

Executive functions are a family of top down mental processes that directly affect the well-being, academic achievement and quality of life of people, and they are developed at an early age. Childhood education (3-6 years old) is an appropriate context to evaluate and to promote the development of those skills but, at the same time, it is necessary to provide tools so that teachers can observe and select individual activities for each student in the classroom. Some researchers have demonstrated that many activities can improve inhibition control and working memory in little children (Diamond, 2016; Traverso, Viterbori & Usai, 2015) but there are few tasks designed specifically for the different dimensions of inhibition control, and there is little research on effects using technological devices. In the TECHCAT Project, a multidisciplinary team of researchers are designing technological solutions to help observe, assess and improve self-regulation skills in a preschool context. Additionally, we consider the role of individuals, school and family factors in moderating children`s development of early self-regulation skills. We use a pre-post design (1 experimental and 2 control groups) with 180 children of 3-6 years old from a preschool in Malaga (Spain). In this paper, we show the characteristics of the experimental design (evaluated skills, standardized test, specific tasks, etc.), and we show results on the design process of the self-regulation tasks using adapted and original tasks: 15 motor inhibition tasks, 11 verbal inhibition tasks, 5 emotional inhibition tasks, and 7 delay reward tasks. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Ministerio de Ciencia y Tecnología.

La lectura a primera vista es una habilidad indispensable para los músicos, por lo que forma parte de numerosos procesos de selección tanto de estudiantes como profesionales. Sin embargo, es una tarea compleja en la que se ven envueltos procesos cognitivos de diferente índole: percepción visual, imagen auditiva y ejecución motora. El objetivo general de este estudio es conocer el proceso de enseñanza-aprendizaje de la lectura a primera vista en los Conservatorios Profesionales de Música de la Comunidad Valenciana, con fines de mejora educativa. La metodología utilizada es de naturaleza tanto cuantitativa como cualitativa, y se ha llevado a cabo a través de una revisión bibliográfica, un análisis descriptivo del currículo, una investigación mediante encuesta al profesorado y un análisis deductivo e inductivo para la creación de una propuesta didáctica. Los resultados ponen de manifiesto un bajo nivel por parte del alumnado y un cierto desconocimiento acerca del proceso de enseñanza-aprendizaje de esta habilidad por parte del profesorado. Esto podría solventarse con la aplicación de técnicas como la práctica regular y constante desde edades tempranas, la enseñanza de la lectura por patrones musicales, una evaluación enfocada a la mejora y la consideración de aspectos psicológicos.

Human induced seismicity has become an uprising problem in the Groningen region of The Netherlands, in which the vast majority of buildings are non-seismically engineered unreinforced masonry houses. In order to accurately assess the seismic vulnerability of these buildings, a characterization of the constitutive masonry is required. In 2015, as a part of a larger project, a campaign on the material characterization of existing buildings was performed, including laboratory and in-situ testing of the masonry walls. The campaign constitutes the germ for the creation of a regional material properties database. 16 buildings were tested in total, comprising residential structures and schools, dating from the early ‘20s to 2005. The constitutive walls included both clay and calcium silicate brick masonry of various qualities and conditions. The in-situ testing included non-destructive tests such as rebound hammer and sonic tests, and semidestructive test, i.e. flat jack and shove test. Samples were carefully taken to the laboratory, where the destructive campaign took place, including compressive, flexural, shear and bond wrench tests. Despite of the limited number of sampled buildings, the campaign provided a better insight of the researched material. The available data suggests that the use of sub-typologies (e.g. depending of the masonry quality or condition) could reduce the dispersion on the results. A first attempt of correlation between in-situ and laboratory tests is proposed, which could benefit from further calibration. In this paper, the material characterization campaign is described, and the main outcomes are discussed.

The determination of the shear strength parameters by means of in-situ shove test is a key issue in the material characterization of unreinforced brick masonry buildings. The wall stress distribution following the removal of the bricks and the mortar joint dilatancy affect the determination of the friction angle and the initial shear strength respectively. A new approach for the definition of the compression in the test unit and the evaluation of the effect of the joint dilatancy on the initial shear strength has been developed. The compression in the test unit is evaluated based on simple formulas which relate the compression stress on the test unit to both the geometry of the specimen and the existing compression on the wall. The joint dilatancy produces an increment of both shear and normal stress at the initial phase of the shove test when the specimen is at low level of compression and at small relative horizontal displacements. In particular, it was observed that the increment of normal stress is due to restrain the tendency of the joint to expand vertically while the brick is pushed. The new approach was validated by means of an experimental benchmark campaign developed at University of Pavia and Delft University of Technology in which specimens made by replicated brick masonry were subjected to triplet tests.

Trabajo fin de grado. Defendido en junio de 2018. Introducción: La muerte es interpretada como un tabú en la sociedad. Hay gran interés en la atención al duelo aunque en el caso de la salud mental exista un estigma histórico. Justificación: Se propone la articulación de un proyecto de investigación para describir las características del duelo normal o patológico en pacientes de salud mental institucionalizados en centros de la Orden Hospitalaria de San Juan de Dios en España. Material y métodos: El conocimiento de las variables sociodemográficas y del proceso de duelo conllevan medidas para mejorar la atención y la calidad de vida. Resultados: Los resultados se compararán con el duelo patológico en personas sanas. Abstract: Introduction: Death is interpreted as a taboo nowadays. There is an enormous interest in the attention to the grief, although an historical stigma exist within the mental health. Justification: It is proposed an investigation project to describe normal or pathological grief characteristics in institutionalized mental health patients in the Orden Hospitalaria de San Juan de Dios centers in Spain. Material and methods: The knowledge of the sociodemographic variables and the duel process carry on policies to improve the attention and life quality. Results: The results will be compared to the pathological grief in mentally healthy people. Ordenador con navegador de Internet; Adobe Acrobat Reader 44 p. (Según el contador de la aplicación)

Melanomas are tumors originating from melanocytes and tend to show early metastasis secondary to the loss of cellular adhesion in the primary tumor, resulting in high mortality rates. Cancer-specific active immunotherapy is an experimental form of treatment that stimulates the immune system to recognize antigens on the surface of cancer cells. Current experimental approaches in immunotherapy include vaccines, biochemotherapy, and the transfer of adoptive T cells and dendritic cells. Several types of vaccines, including peptide, viral, and dendritic cell vaccines, are currently under investigation for the treatment of melanoma. These treatments have the same goal as drugs that are already used to stimulate the proliferation of T lymphocytes in order to destroy tumor cells; however, immunotherapies aim to selectively attack the tumor cells of each patient. In this comprehensive review, we describe recent advancements in the development of immunotherapies for melanoma, with a specific focus on the identification of neoantigens for the prediction of their elicited immune responses. This review is expected to provide important insights into the future of immunotherapy for melanoma.

Accelerated life tests are frequently used to provide reliability information in a moderate period of time (weeks or months), and after that, a failure analysis is compulsory to detect the failure origins. In this paper, a failure analysis has been carried out after a temperature accelerated life test on lattice matched GaInP/Ga(In)As/Ge triple junction commercial solar cells. Solar cells were forward biased in darkness inside three climatic chambers in order to emulate the photo-generated current under nominal working conditions (a concentration level of 820 suns). After the accelerated aging test, a characterization of the resulting cells by means of quantum efficiency, dark and illumination I?V curves, electroluminescence, scanning electron microscope, energy dispersive X-ray, scanning transmission electron microscope and X-ray photoelectron spectroscopy has been carried out. Current is identified as the cause of degradation while temperature just dominates the accelerating factor of the aging test. Current promotes the front metal damage produced by the chemical evolution of the electroplating impurities together with those of the tab soldering process. Semiconductor structure does not seem to be responsible of any failure. Therefore, this kind of lattice matched GaInP/Ga(In)As/Ge triple junction solar cells, that as of 2016, are the workhorse of CPV technology, exhibits as a very robust device if the front metal connection is properly accomplished.

Apoyándonos en un caso seleccionado y la revisión de la bibliografía más reciente sobre los Trastornos disociativos y las Psicosis en la infancia y la adolescencia y las alteraciones sensoperceptivas propias del desarrollo, se analizan detenidamente las características de dichas categorías clínicas y las dificultades a la hora de realizar el diagnóstico diferencial. Se extraen finalmente una serie de conclusiones orientadas a realizar un diagnóstico correcto debido a la importancia de una atención precoz e individualizada y a la disparidad del pronóstico en cada una de las condiciones citadas., Grado en Medicina

Este artículo es ante todo una reivindicación del urbanismo como materia compleja que se alimenta de la historia colectiva, de sus mitos y de sus aspiraciones. El urbanismo actual ha devenido en una técnica aséptica que se ocupa preferentemente de los derechos de propiedad y de la inserción de infraestructuras, pero la ciudad es un artificio sofisticado. Su entendimiento no puede conformarse con cifras, estándares e indicadores. La ciudad, como el remero en la regata, avanza mirando hacia atrás. Las ciudades forjan su identidad a través de historias, de mitos. Toda ciudad tiende a parecerse a su nombre. Nos acercamos a Venecia y a San Petersburgo, porque en su radical artificiosidad, son ejemplo claro de cómo la ciudad está por encima de las condiciones objetivamente razonables. Examinamos sus avatares históricos, su inserción en el arte y en la literatura, que les proporcionan héroes y escenarios. Pero este no es un ensayo histórico, de todo ello obtenemos conclusiones aplicables al tratamiento de nuestras ciudades para refundar el urbanismo como arte con el que fertilizar a la técnica. Según la Biblia las ciudades debían construirse sobre roca. Para estas ciudades nacidas en el fango, su roca ha sido la cohesión social creada por un mito identitario. Algo que puede ser útil y fértil para otras muchas ciudades. This paper represents above all recognition of the city planning as a complex issue that nurtures itself from collective history, its myths and aspirations. Present city planning has turned into an aseptic technic that is only concerned with property rights and insertion of infrastructures. Nevertheless the city is a sophisticated artifice. We cannot only understand it only with numbers, standards and indicators. The city, as the rower in a regatta, moves forward, but looking back. Cities forge their identity through history, myths. Each city tends to look like its name. We will approach Venice and Saint Petersburg because, in their radical artificiality, they are obvious examples of how cities are above objectively reasonable conditions. We will examine their historic avatars, their inclusion in the art and the literature, which provide heroes and settings. Yet this is not a historic study, we will reach conclusions that can apply to the treatment of our cities to refund our city planning as an art able to fertilize technique. Following the Bible, cities must be built on stones. For those cities that were built with mud, stones have been social cohesion created thanks to the distinctiveness of a myth, something that can be useful and fertile for many other cities. Sin financiación No data JCR 2017 No data SJR 2017 0.028 IDR (2017) C4, 80/135 Arte

[EN] Construct design and validation is a common practise in the Operations Management field. In this sense, the aim of this study is to present Rasch Measurement Theory (RMT) as richful and useful methodology in order to validate constructs. In order to do so, the measurement controversy in the social science is presented; then, RMT is explained as a solution for this measurement issue; after that, the different applications of RMT are described and, finally, the different stages of the validation process are presented. Thus, this work aims to serve as a guide for those researchers interested in the methodology. Therefore, a specific case is included: the validation of the construct “motivation to implement continuous improvement”., [ES] El diseño y validación de constructos es una práctica habitual en el campo de investigación de la Dirección de Operaciones. En esta línea, el objetivo de este trabajo es presentar la Teoría de la Medición de Rasch (TMR) como metodología para la validación de constructos. Para ello se describe la problemática de medición concreta de las ciencias sociales, cómo la Teoría de la Medición de Rasch da respuesta a esa problemática, las distintas aplicaciones de la TMR, así como las diferentes etapas a realizar para comprobar si un constructo es válido o no. Así, el trabajo pretende servir de guía para todos aquellos interesados en la metodología. Para ello se ofrece un caso concreto de aplicación al constructo “motivación para implantar la mejora continua”

The aim of this paper is to present the results of a review of Hispanic literature about continuous improvement. A rigorous review of papers included in the Dialnet data base was conducted, combining both qualitative and quantitative methods. The main results show that continuous improvement is an important field in Hispanic output although certain topics should be delved into more deeply. General knowledge journals aimed at practitioners are those that tend to publish papers related to continuous improvement, thus highlighting the relevance of the topic for practitioners. The paper offers two main contributions. First, it is novel research not been previously done in the Hispanic context. Secondly, it clarifies and complements the conclusions drawn by international reviews according to which continuous improvement seemed to be scarcely addressed in Hispanic output. El objetivo de este trabajo es realizar una revisión del campo de la Mejora Continua en la literatura. Para ello se realiza una revisión rigurosa tanto con métodos cualitativos como cuantitativos a partir de los trabajos recogidos en la base de datos Dialnet. Los principales resultados muestran que la mejora continua es un campo importante en la literatura hispana, aunque debe potenciarse en ciertas temáticas. También se detectó una clara orientación divulgativa del tema resaltando así la importancia de la mejora continua para los profesionales del sector. El trabajo tiene dos aportaciones principales. En primer lugar, es un estudio novedoso que no se había realizado previamente en la literatura hispana. Y, en segundo lugar, matiza y complementa las conclusiones obtenidas por revisiones internacionales según las cuales la mejora continua parecía no estar desarrollada en la literatura hispana.

Los avances ocurridos en el campo de la biología en las últimas décadas han revolucionado nuestra percepción del mundo y de nosotros mismos. Dentro de este avance general, dos disciplinas han contribuido de forma particularmente prominente a esa nueva visión: la neurociencia y la epigenética.