5,420 results on '"Boffetta, Paolo"'
Search Results
102. Re : Exposure to asbestos and the risk of colorectal cancer mortality: a systematic review and meta-analysis by Kwak et al
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Boffetta, Paolo
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- 2020
103. Reporting only relative effect measures was potentially misleading: some good practices for improving the soundness of epidemiological results
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Novelli, Marco, Baldi Antognini, Alessandro, Boffetta, Paolo, Ioannidis, John PA, Spatari, Giovanna, and Violante, Francesco S
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- 2021
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104. Occupational exposure to asbestos and risk of kidney cancer: an updated meta-analysis
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Zunarelli, Carlotta, Godono, Alessandro, Visci, Giovanni, Violante, Francesco S., and Boffetta, Paolo
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- 2021
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105. Cancer epidemiology and public health
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Boffetta, Paolo, additional, Zhang, Zuo-Feng, additional, and Vecchia, Carlo La, additional
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- 2021
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106. Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study
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Fehringer, Gordon, Brenner, Darren R, Zhang, Zuo‐Feng, Lee, Yuan‐Chin Amy, Matsuo, Keitaro, Ito, Hidemi, Lan, Qing, Vineis, Paolo, Johansson, Mattias, Overvad, Kim, Riboli, Elio, Trichopoulou, Antonia, Sacerdote, Carlotta, Stucker, Isabelle, Boffetta, Paolo, Brennan, Paul, Christiani, David C, Hong, Yun‐Chul, Landi, Maria Teresa, Morgenstern, Hal, Schwartz, Ann G, Wenzlaff, Angela S, Rennert, Gad, McLaughlin, John R, Harris, Curtis C, Olivo‐Marston, Susan, Orlow, Irene, Park, Bernard J, Zauderer, Marjorie, Dios, Juan M Barros, Raviña, Alberto Ruano, Siemiatycki, Jack, Koushik, Anita, Lazarus, Philip, Fernández‐Somoano, Ana, Tardon, Adonina, Le Marchand, Loic, Brenner, Hermann, Saum, Kai‐Uwe, Duell, Eric J, Andrew, Angeline S, Szeszenia‐Dabrowska, Neonila, Lissowska, Jolanta, Zaridze, David, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Foretova, Lenka, Janout, Vladimir, Bencko, Vladimir, Holcatova, Ivana, Pesatori, Angela Cecilia, Consonni, Dario, Olsson, Ann, Straif, Kurt, and Hung, Rayjean J
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Lung ,Cancer ,Substance Misuse ,Tobacco ,Alcoholism ,Alcohol Use and Health ,Tobacco Smoke and Health ,Prevention ,Lung Cancer ,Cardiovascular ,Stroke ,Respiratory ,Good Health and Well Being ,Aged ,Alcohol Drinking ,Alcoholic Beverages ,Asia ,Case-Control Studies ,Cohort Studies ,Europe ,Female ,Humans ,Lung Neoplasms ,Male ,Middle Aged ,North America ,Risk Factors ,Smoking ,alcohol ,lung cancer ,wine ,beer ,liquor ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0-4.9 g per day: OR = 0.80, 95% CI = 0.70-0.90; 5-9.9 g per day: OR = 0.82, 95% CI = 0.69-0.99; 10-19.9 g per day: OR = 0.79, 95% CI = 0.65-0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance.
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- 2017
107. Hepatocellular carcinoma detection: diagnostic performance of a simulated abbreviated MRI protocol combining diffusion-weighted and T1-weighted imaging at the delayed phase post gadoxetic acid
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Besa, Cecilia, Lewis, Sara, Pandharipande, Pari V, Chhatwal, Jagpreet, Kamath, Amita, Cooper, Nancy, Knight-Greenfield, Ashley, Babb, James S, Boffetta, Paolo, Padron, Norma, Sirlin, Claude B, and Taouli, Bachir
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Clinical Research ,Digestive Diseases ,Biomedical Imaging ,Liver Disease ,Rare Diseases ,Cancer ,Liver Cancer ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Adult ,Aged ,Aged ,80 and over ,Carcinoma ,Hepatocellular ,Contrast Media ,Diffusion Magnetic Resonance Imaging ,Female ,Gadolinium DTPA ,Humans ,Liver Neoplasms ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Retrospective Studies ,Sensitivity and Specificity ,Hepatocellular carcinoma ,MRI ,Diffusion-weighted imaging ,Gadoxetic acid - Abstract
PurposeThe purpose of this study was to evaluate the diagnostic performance of a "simulated" abbreviated MRI (AMRI) protocol using diffusion-weighted imaging (DWI) and T1-weighted (T1w) imaging obtained at the hepatobiliary phase (HBP) post gadoxetic acid injection alone and in combination, compared to dynamic contrast-enhanced (CE)-T1w imaging for the detection of hepatocellular carcinoma (HCC).MethodsThis was an IRB approved HIPAA compliant retrospective single institution study including patients with liver disease who underwent gadoxetic acid-enhanced MRI for HCC diagnosis. Three independent observers assessed 2 sets of images (full CE-set and AMRI including DWI+T1w-HBP). Diagnostic performance of T1w-HBP and DWI alone and in combination was compared to that of CE-set. All imaging sets included unenhanced T1w and T2w sequences. A preliminary analysis was performed to assess cost savings of AMRI protocol compared to a full MRI study.Results174 patients including 62 with 80 HCCs were assessed. Equivalent per-patient sensitivity and negative predictive value (NPV) were observed for DWI (85.5% and 92.2%, pooled data) and T1w-HBP (89.8% and 94.2%) (P = 0.1-0.7), while these were significantly lower for the full AMRI protocol (DWI+T1w-HBP, 80.6% and 80%, P = 0.02) when compared to CE-set (90.3% and 94.9%). Higher specificity and positive predictive value were observed for CE-set vs. AMRI (P = 0.02). The estimated cost reduction of AMRI versus full MRI ranged between 30.7 and 49.0%.ConclusionAMRI using DWI and T1w-HBP has a clinically acceptable sensitivity and NPV for HCC detection. This could serve as the basis for a future study assessing AMRI for HCC screening and surveillance.
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- 2017
108. Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium
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Amadou, Amina, Freisling, Heinz, Jenab, Mazda, Tsilidis, Konstantinos K., Trichopoulou, Antonia, Boffetta, Paolo, Van Guelpen, Bethany, Mokoroa, Olatz, Wilsgaard, Tom, Kee, Frank, Schöttker, Ben, Ordóñez-Mena, José M., Männistö, Satu, Söderberg, Stefan, Vermeulen, Roel C. H., Quirós, J. Ramón, Liao, Linda M., Sinha, Rashmi, Kuulasmaa, Kari, Brenner, Hermann, and Romieu, Isabelle
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- 2021
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109. Dietary quality using four dietary indices and lung cancer risk: the Golestan Cohort Study (GCS)
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Wang, Qian, Hashemian, Maryam, Sepanlou, Sadaf G., Sharafkhah, Maryam, Poustchi, Hossein, Khoshnia, Masoud, Gharavi, Abdolsamad, Pourshams, Akram, Malekshah, Akbar Fazeltabar, Kamangar, Farin, Etemadi, Arash, Abnet, Christian C., Dawsey, Sanford M., Malekzadeh, Reza, and Boffetta, Paolo
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- 2021
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110. Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer
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Lesseur, Corina, Diergaarde, Brenda, Olshan, Andrew F, Wünsch-Filho, Victor, Ness, Andrew R, Liu, Geoffrey, Lacko, Martin, Eluf-Neto, José, Franceschi, Silvia, Lagiou, Pagona, Macfarlane, Gary J, Richiardi, Lorenzo, Boccia, Stefania, Polesel, Jerry, Kjaerheim, Kristina, Zaridze, David, Johansson, Mattias, Menezes, Ana M, Curado, Maria Paula, Robinson, Max, Ahrens, Wolfgang, Canova, Cristina, Znaor, Ariana, Castellsagué, Xavier, Conway, David I, Holcátová, Ivana, Mates, Dana, Vilensky, Marta, Healy, Claire M, Szeszenia-Dąbrowska, Neonila, Fabiánová, Eleonóra, Lissowska, Jolanta, Grandis, Jennifer R, Weissler, Mark C, Tajara, Eloiza H, Nunes, Fabio D, de Carvalho, Marcos B, Thomas, Steve, Hung, Rayjean J, Peters, Wilbert HM, Herrero, Rolando, Cadoni, Gabriella, Bueno-de-Mesquita, H Bas, Steffen, Annika, Agudo, Antonio, Shangina, Oxana, Xiao, Xiangjun, Gaborieau, Valérie, Chabrier, Amélie, Anantharaman, Devasena, Boffetta, Paolo, Amos, Christopher I, McKay, James D, and Brennan, Paul
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Biological Sciences ,Genetics ,Cancer ,Clinical Research ,Dental/Oral and Craniofacial Disease ,Digestive Diseases ,Human Genome ,Aetiology ,2.1 Biological and endogenous factors ,Aged ,Case-Control Studies ,Female ,Genetic Markers ,Genetic Predisposition to Disease ,Genetic Variation ,Genome-Wide Association Study ,HLA Antigens ,Haplotypes ,Humans ,Male ,Middle Aged ,Mouth ,Mouth Neoplasms ,Papillomaviridae ,Papillomavirus Infections ,Pharyngeal Neoplasms ,Medical and Health Sciences ,Developmental Biology ,Agricultural biotechnology ,Bioinformatics and computational biology - Abstract
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10-8), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10-9). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10-6) than in HPV-negative (OR = 0.75, P = 0.16) cancers.
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- 2016
111. Smokeless Tobacco Use and the Risk of Head and Neck Cancer: Pooled Analysis of US Studies in the INHANCE Consortium
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Wyss, Annah B, Hashibe, Mia, Lee, Yuan-Chin Amy, Chuang, Shu-Chun, Muscat, Joshua, Chen, Chu, Schwartz, Stephen M, Smith, Elaine, Zhang, Zuo-Feng, Morgenstern, Hal, Wei, Qingyi, Li, Guojun, Kelsey, Karl T, McClean, Michael, Winn, Deborah M, Schantz, Stimson, Yu, Guo-Pei, Gillison, Maura L, Zevallos, Jose P, Boffetta, Paolo, and Olshan, Andrew F
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Epidemiology ,Health Services and Systems ,Health Sciences ,Tobacco ,Dental/Oral and Craniofacial Disease ,Rare Diseases ,Prevention ,Cancer ,Tobacco Smoke and Health ,Good Health and Well Being ,Adolescent ,Adult ,Aged ,Cigarette Smoking ,Female ,Head and Neck Neoplasms ,Humans ,Logistic Models ,Male ,Middle Aged ,Mouth Neoplasms ,Tobacco Use ,Tobacco ,Smokeless ,United States ,Young Adult ,chewing tobacco ,head and neck neoplasms ,snuff ,tobacco ,smokeless ,Mathematical Sciences ,Medical and Health Sciences - Abstract
Previous studies on smokeless tobacco use and head and neck cancer (HNC) have found inconsistent and often imprecise estimates, with limited control for cigarette smoking. Using pooled data from 11 US case-control studies (1981-2006) of oral, pharyngeal, and laryngeal cancers (6,772 cases and 8,375 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium, we applied hierarchical logistic regression to estimate odds ratios and 95% confidence intervals for ever use, frequency of use, and duration of use of snuff and chewing tobacco separately for never and ever cigarette smokers. Ever use (versus never use) of snuff was strongly associated with HNC among never cigarette smokers (odds ratio (OR) = 1.71, 95% confidence interval (CI): 1.08, 2.70), particularly for oral cavity cancers (OR = 3.01, 95% CI: 1.63, 5.55). Although ever (versus never) tobacco chewing was weakly associated with HNC among never cigarette smokers (OR = 1.20, 95% CI: 0.81, 1.77), analyses restricted to cancers of the oral cavity showed a stronger association (OR = 1.81, 95% CI: 1.04, 3.17). Few or no associations between each type of smokeless tobacco and HNC were observed among ever cigarette smokers, possibly reflecting residual confounding by smoking. Smokeless tobacco use appears to be associated with HNC, especially oral cancers, with snuff being more strongly associated than chewing tobacco.
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- 2016
112. Occupational asbestos exposure and risk of esophageal cancer: A systematic review and meta‐analysis.
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Seyyedsalehi, Monireh Sadat and Boffetta, Paolo
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OCCUPATIONAL exposure ,DISEASE risk factors ,RISK exposure ,SQUAMOUS cell carcinoma ,ASBESTOS - Abstract
Esophageal cancer (EC), which includes squamous cell carcinoma (ESCC) and adenocarcinoma (EAC), is an important cancer with poor prognosis and high mortality rate. Several occupational exposures have been associated with EC. We aim to investigate the association between occupational asbestos exposure and EC risk, considering types of asbestos and histology of the disease. We included studies mentioned in the list of references in previous reviews and pooled analyses, and we conducted an independent search in PubMed and Scopus. Forest plots of relative risks (RR) were constructed based on the association between occupational asbestos and EC risk. Random‐effects models were used to address heterogeneity between 48 independent cohort and case‐control studies. We found an association between occupational asbestos exposure and EC (meta‐relative risk [RR] = 1.20, 95% confidence interval [CI] = 1.09‐1.32; I2 = 58.8%, p‐heterogeneity [het] <.001). The results of stratification by job (p‐het =.20) indicate an increased RR among asbestos product workers (RR = 1.39, 95% CI = 1.07‐1.81), asbestos applicators (RR = 1.41, 95% CI = 1.20‐1.67), and construction workers (RR = 1.12, 95% CI = 1.02‐1.24). There was no heterogeneity in meta‐RR according to outcome (p =.29), geographic region (p =.69), year of publication (p =.59), quality score (p =.73), asbestos type (p =.93), study design (p =.87), and gender (p =.88), control for potential confounders (p =.20), year of first employment (p =.94) and exposure level (p =.43). The stratification analysis by histology type found an increased RR for both ESCC 1.33(1.03‐1.71) and EAC 1.45(1.03‐2.04) (p‐het =.68). We didn't find evidence of publication bias (p =.07). The results of our study suggest that occupational asbestos exposure is associated with an increased risk of EC in both histology types. [ABSTRACT FROM AUTHOR]
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- 2024
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113. Risk of Gynecological and Breast Cancers in Workers Exposed to Diesel Exhaust: A Systematic Review and Meta-Analysis of Cohort Studies.
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D'Agostini, Marika, Collatuzz, Giulia, Teglia, Federica, and Boffetta, Paolo
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Background: This study aimed to explore the association between occupational exposure to diesel exhaust (DE) and gynaecological and breast cancers. Methods: A systematic review was performed to identify cohort studies reporting results on the association between occupational exposure to DE and risk of gynaecological and breast cancers. STROBE guidelines and PECOS criteria were followed. We identified 6 studies for breast cancer (BC), 4 for cervical cancer (CC), 4 for endometrial cancer (EC) and 7 for ovarian cancer (OC). Random-effects meta-analyses were conducted on the relationship between DE exposure and BC, CC, EC, and OC risk; 95% Confidence Intervals (CI) and prediction intervals (PI) were reported. We investigated between-study heterogeneity and potential publication bias using Egger's test. Results: No associations were observed between occupational DE exposure and risk of BC [RR=0.93; CI: 0.77-1.13; PI:0.50-1.73, I2=80.31% (CI: 21.72-95.05%)], EC [RR=0.89; CI: 0.75-1.05; PI:0. 61-1.30, I2=0.78% (CI: 0-85.57%)], and OC [RR=1.08; CI: 0.89-1.32, PI: 0.76-1.56, I2=11.87% (CI: 0-74.42%)]. A weak association was observed for CC [RR=1.41; CI: 1.17-1.17; PI:0.85-2.30, I2=6.44% (CI: 0-86.40%)]. No between-study heterogeneity or publication bias was detected. Conclusions: This study identified an association between DE exposure and CC, which was not adjusted for potential confounders. No evidence of an association was found with BC, EC, and OC. [ABSTRACT FROM AUTHOR]
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- 2024
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114. Dietary habits and the 10-year risk of overweight and obesity in urban adult population: A cohort study predicated on Yazd Healthy Heart Project
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Sarebanhassanabadi, Mohammadtaghi, Shahriari Kalantari, Manijeh, Boffetta, Paolo, Beiki, Omid, Pakseresht, Mohammadreza, Sarrafzadegan, Nizal, Mirzaei, Masoud, Kraemer, Alexander, Seyedhosseini, Seyedmostafa, Mali, Shahriar, Namayandeh, Seyedeh Mahdieh, Razavi, Seyed Kazem, Alipour, Mohammad Reza, Emami, Mahmood, Ahmad Abad, Mostafa Shokati, Hosseini, Habib Allah, and Salehi-Abargouei, Amin
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- 2020
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115. Childhood cancer mortality trends in Europe, 1990-2017, with focus on geographic differences
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Bertuccio, Paola, Alicandro, Gianfranco, Malvezzi, Matteo, Carioli, Greta, Boffetta, Paolo, Levi, Fabio, La Vecchia, Carlo, and Negri, Eva
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- 2020
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116. Opium use and subsequent incidence of cancer: results from the Golestan Cohort Study
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Sheikh, Mahdi, Shakeri, Ramin, Poustchi, Hossein, Pourshams, Akram, Etemadi, Arash, Islami, Farhad, Khoshnia, Masoud, Gharavi, Abdolsamad, Roshandel, Gholamreza, Khademi, Hooman, Sepanlou, Sadaf G, Hashemian, Maryam, Fazel, Abdolreza, Zahedi, Mahdi, Abedi-Ardekani, Behnoush, Boffetta, Paolo, Dawsey, Sanford M, Pharoah, Paul D, Sotoudeh, Masoud, Freedman, Neal D, Abnet, Christian C, Day, Nicholas E, Brennan, Paul, Kamangar, Farin, and Malekzadeh, Reza
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- 2020
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117. Liver transplant for hepatocellular carcinoma in the United States: Evolving trends over the last three decades
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Puigvehí, Marc, Hashim, Dana, Haber, Philipp K., Dinani, Amreen, Schiano, Thomas D., Asgharpour, Amon, Kushner, Tatyana, Kakked, Gaurav, Tabrizian, Parissa, Schwartz, Myron, Gurakar, Ahmet, Dieterich, Douglas, Boffetta, Paolo, Friedman, Scott L., Llovet, Josep M., and Saberi, Behnam
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- 2020
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118. Diesel exhaust exposure and risk of non-Hodgkin lymphoma: a meta-analysis
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Vilardi, Valeria and Boffetta, Paolo
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- 2021
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119. Mouthwash use and cancer of the head and neck
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Boffetta, Paolo, Hayes, Richard B, Sartori, Samantha, Lee, Yuan-Chin A, Muscat, Joshua, Olshan, Andrew, Winn, Deborah M, Castellsagué, Xavier, Zhang, Zuo-Feng, Morgenstern, Hal, Chen, Chu, Schwartz, Stephen M, Vaughan, Thomas L, Wunsch-Filho, Victor, Purdue, Mark, Koifman, Sergio, Curado, Maria P, Vilensky, Marta, Gillison, Maura, Fernandez, Leticia, Menezes, Ana, Daudt, Alexander W, Schantz, Stimson, Yu, Guopei, D’Souza, Gypsyamber, Haddad, Robert I, La Vecchia, Carlo, and Hashibe, Mia
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Health Services and Systems ,Biomedical and Clinical Sciences ,Health Sciences ,Tobacco ,Digestive Diseases ,Prevention ,Tobacco Smoke and Health ,Cancer ,Dental/Oral and Craniofacial Disease ,Substance Misuse ,Oral and gastrointestinal ,Good Health and Well Being ,Adult ,Case-Control Studies ,Female ,Follow-Up Studies ,Head and Neck Neoplasms ,Humans ,International Agencies ,Male ,Meta-Analysis as Topic ,Mouthwashes ,Prevalence ,Prognosis ,Retrospective Studies ,Risk Factors ,alcohol ,head and neck cancer ,laryngeal cancer ,mouthwash ,oral cancer ,pharyngeal cancer ,Oncology and Carcinogenesis ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis ,Public health - Abstract
Most mouthwashes contain alcohol, a known cause of head and neck cancer (oral cavity, pharynx, larynx), likely through the carcinogenic activity of acetaldehyde, formed in the oral cavity from alcohol. We carried out a pooled analysis of 8981 cases of head and neck cancer and 10 090 controls from 12 case-control studies with comparable information on mouthwash use in the International Head and Neck Cancer Epidemiology Consortium. Logistic regression was used to assess the association of mouthwash use with cancers of the oral cavity, oropharynx, hypopharynx, and larynx, adjusting for study, age, sex, pack-years of tobacco smoking, number of alcoholic drinks/day, and education. Compared with never users of mouthwash, the odds ratio (OR) of all head and neck cancers was 1.01 [95% confidence interval (CI): 0.94-1.08] for ever users, based on 12 studies. The corresponding ORs of cancer of the oral cavity and oropharynx were 1.11 (95% CI: 1.00-1.23) and 1.28 (95% CI: 1.06-1.56), respectively. OR for all head and neck cancer was 1.15 (95% CI: 1.01-1.30) for use for more than 35 years, based on seven studies (P for linear trend=0.01), and OR 1.31 (95% CI: 1.09-1.58) for use more than one per day, based on five studies (P for linear trend
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- 2016
120. Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis
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Berthiller, Julien, Straif, Kurt, Agudo, Antonio, Ahrens, Wolfgang, dos Santos, Alexandre Bezerra, Boccia, Stefania, Cadoni, Gabriella, Canova, Cristina, Castellsague, Xavier, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Fukuyama, Erica E, Hayes, Richard B, Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Sergio, Lagiou, Pagona, La Vecchia, Carlo, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, Macfarlane, Tatiana, Mates, Dana, McClean, Michael, Menezes, Ana, Merletti, Franco, Morgenstern, Hal, Muscat, Joshua, Olshan, Andrew F, Purdue, Mark, Ramroth, Heribert, Rudnai, Peter, Schwartz, Stephen M, Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M, Szeszenia-Dabrowska, Neonila, Thomson, Peter, Vaughan, Thomas L, Vilensky, Marta, Wei, Qingyi, Winn, Deborah M, Wünsch-Filho, Victor, Zhang, Zuo-Feng, Znaor, Ariana, Ferro, Gilles, Brennan, Paul, Boffetta, Paolo, Hashibe, Mia, and Lee, Yuan-Chin Amy
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Cancer ,Prevention ,Dental/Oral and Craniofacial Disease ,Tobacco Smoke and Health ,Substance Misuse ,Clinical Research ,Rare Diseases ,Tobacco ,Respiratory ,Good Health and Well Being ,Adult ,Aged ,Alcohol Drinking ,Case-Control Studies ,Cigarette Smoking ,Female ,Head and Neck Neoplasms ,Humans ,Logistic Models ,Male ,Middle Aged ,Odds Ratio ,Public Health ,Risk Factors ,Head and neck cancer ,low frequency cigarette smoking ,risk factors ,pooled analysis ,Statistics ,Public Health and Health Services ,Epidemiology - Abstract
BackgroundCigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (0-3, >3-5, >5-10 cigarettes per day.ResultsSmoking >0-3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) = 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3-5 cigarettes per day was associated in each subgroup from OR = 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR = 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR = 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years.ConclusionOur results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.
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- 2016
121. Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes
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Machiela, Mitchell J, Lan, Qing, Slager, Susan L, Vermeulen, Roel CH, Teras, Lauren R, Camp, Nicola J, Cerhan, James R, Spinelli, John J, Wang, Sophia S, Nieters, Alexandra, Vijai, Joseph, Yeager, Meredith, Wang, Zhaoming, Ghesquières, Hervé, McKay, James, Conde, Lucia, de Bakker, Paul IW, Cox, David G, Burdett, Laurie, Monnereau, Alain, Flowers, Christopher R, De Roos, Anneclaire J, Brooks-Wilson, Angela R, Giles, Graham G, Melbye, Mads, Gu, Jian, Jackson, Rebecca D, Kane, Eleanor, Purdue, Mark P, Vajdic, Claire M, Albanes, Demetrius, Kelly, Rachel S, Zucca, Mariagrazia, Bertrand, Kimberly A, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Hutchinson, Amy, Zhi, Degui, Habermann, Thomas M, Link, Brian K, Novak, Anne J, Dogan, Ahmet, Asmann, Yan W, Liebow, Mark, Thompson, Carrie A, Ansell, Stephen M, Witzig, Thomas E, Tilly, Hervé, Haioun, Corinne, Molina, Thierry J, Hjalgrim, Henrik, Glimelius, Bengt, Adami, Hans-Olov, Roos, Göran, Bracci, Paige M, Riby, Jacques, Smith, Martyn T, Holly, Elizabeth A, Cozen, Wendy, Hartge, Patricia, Morton, Lindsay M, Severson, Richard K, Tinker, Lesley F, North, Kari E, Becker, Nikolaus, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Staines, Anthony, Lightfoot, Tracy, Crouch, Simon, Smith, Alex, Roman, Eve, Diver, W Ryan, Offit, Kenneth, Zelenetz, Andrew, Klein, Robert J, Villano, Danylo J, Zheng, Tongzhang, Zhang, Yawei, Holford, Theodore R, Turner, Jenny, Southey, Melissa C, Clavel, Jacqueline, Virtamo, Jarmo, Weinstein, Stephanie, Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Boeing, Heiner, Tjønneland, Anne, Angelucci, Emanuele, Di Lollo, Simonetta, Rais, Marco, De Vivo, Immaculata, Giovannucci, Edward, Kraft, Peter, and Huang, Jinyan
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Clinical Research ,Rare Diseases ,Genetics ,Cancer ,Hematology ,Lymphoma ,Adolescent ,Adult ,Age Factors ,Aged ,Aged ,80 and over ,Female ,Genetic Association Studies ,Genetic Predisposition to Disease ,Humans ,Lymphoma ,B-Cell ,Male ,Middle Aged ,Prospective Studies ,Telomere ,Biological Sciences ,Medical and Health Sciences ,Genetics & Heredity - Abstract
Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82,P-value = 8.5 × 10(-5)]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51,P-value = 4.0 × 10(-10)). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere length may increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk.
- Published
- 2016
122. Carotenoid intake and head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
- Author
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Leoncini, Emanuele, Edefonti, Valeria, Hashibe, Mia, Parpinel, Maria, Cadoni, Gabriella, Ferraroni, Monica, Serraino, Diego, Matsuo, Keitaro, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Kelsey, Karl, McClean, Michael, Bosetti, Cristina, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Lee, Yuan-Chin Amy, Chuang, Shu-Chun, Decarli, Adriano, La Vecchia, Carlo, and Boccia, Stefania
- Subjects
Public Health ,Health Sciences ,Dental/Oral and Craniofacial Disease ,Nutrition ,Digestive Diseases ,Prevention ,Rare Diseases ,Cancer ,Oral and gastrointestinal ,Good Health and Well Being ,Adult ,Aged ,Aged ,80 and over ,Antioxidants ,Carcinoma ,Squamous Cell ,Carotenoids ,Case-Control Studies ,Epidemiologic Studies ,Europe ,Female ,Head and Neck Neoplasms ,Humans ,Japan ,Middle Aged ,Squamous Cell Carcinoma of Head and Neck ,United States ,Head and neck cancer ,Nutrients ,Diet ,Public Health and Health Services ,Epidemiology - Abstract
Food and nutrition play an important role in head and neck cancer (HNC) etiology; however, the role of carotenoids remains largely undefined. We explored the relation of HNC risk with the intake of carotenoids within the International Head and Neck Cancer Epidemiology Consortium. We pooled individual-level data from 10 case-control studies conducted in Europe, North America, and Japan. The analysis included 18,207 subjects (4414 with oral and pharyngeal cancer, 1545 with laryngeal cancer, and 12,248 controls), categorized by quintiles of carotenoid intake from natural sources. Comparing the highest with the lowest quintile, the risk reduction associated with total carotenoid intake was 39 % (95 % CI 29-47 %) for oral/pharyngeal cancer and 39 % (95 % CI 24-50 %) for laryngeal cancer. Intakes of β-carotene equivalents, β-cryptoxanthin, lycopene, and lutein plus zeaxanthin were associated with at least 18 % reduction in the rate of oral and pharyngeal cancer (95 % CI 6-29 %) and 17 % reduction in the rate of laryngeal cancer (95 % CI 0-32 %). The overall protective effect of carotenoids on HNC was stronger for subjects reporting greater alcohol consumption (p
- Published
- 2016
123. Occupational-related exposure to diesel exhaust and risk of leukemia: systematic review and meta-analysis of cohort studies
- Author
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Shah, Darshi, primary, DeStefano, Vincent, additional, Collatuzzo, Giulia, additional, Teglia, Federica, additional, and Boffetta, Paolo, additional
- Published
- 2023
- Full Text
- View/download PDF
124. Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project
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Song, Minkyo, primary, Jayasekara, Harindra, additional, Pelucchi, Claudio, additional, Rabkin, Charles S., additional, Johnson, Kenneth C., additional, Hu, Jinfu, additional, Palli, Domenico, additional, Ferraroni, Monica, additional, Liao, Linda M., additional, Bonzi, Rossella, additional, Zaridze, David, additional, Maximovitch, Dmitry, additional, Aragonés, Nuria, additional, Martin, Vicente, additional, Castaño-Vinyals, Gemma, additional, Guevara, Marcela, additional, Tsugane, Shoichiro, additional, Hamada, Gerson Shigueaki, additional, Hidaka, Akihisa, additional, Negri, Eva, additional, Ward, Mary H., additional, Sinha, Rashmi, additional, Lagiou, Areti, additional, Lagiou, Pagona, additional, Boffetta, Paolo, additional, Curado, Maria Paula, additional, Lunet, Nuno, additional, Vioque, Jesus, additional, Zhang, Zuo-Feng, additional, La Vecchia, Carlo, additional, and Camargo, M. Constanza, additional
- Published
- 2023
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- View/download PDF
125. Determinants of waterpipe smoking in Iranian adults: results from the IROPICAN study
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Seyyedsalehi, Monireh Sadat, primary, Shah, Aneri, additional, Rashidian, Hamideh, additional, Hadji, Maryam, additional, Marzban, Maryam, additional, Ansari-Moghaddam, Alireza, additional, Nejatizadeh, Azim, additional, Boffetta, Paolo, additional, and Zendehdel, Kazem, additional
- Published
- 2023
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- View/download PDF
126. Obesity is associated with biliary tract cancer mortality and incidence: A pooled analysis of 21 cohort studies in the Asia Cohort Consortiumc
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Oze, Isao, primary, Ito, Hidemi, additional, Koyanagi, Yuriko N., additional, Abe, Sarah Krull, additional, Rahman, Md. Shafiur, additional, Islam, Md. Rashedul, additional, Saito, Eiko, additional, Gupta, Prakash C., additional, Sawada, Norie, additional, Tamakoshi, Akiko, additional, Shu, Xiao‐Ou, additional, Sakata, Ritsu, additional, Malekzadeh, Reza, additional, Tsuji, Ichiro, additional, Kim, Jeongseon, additional, Nagata, Chisato, additional, You, San‐Lin, additional, Park, Sue K., additional, Yuan, Jian‐Min, additional, Shin, Myung‐Hee, additional, Kweon, Sun‐Seog, additional, Pednekar, Mangesh S., additional, Tsugane, Shoichiro, additional, Kimura, Takashi, additional, Gao, Yu‐Tang, additional, Cai, Hui, additional, Pourshams, Akram, additional, Lu, Yukai, additional, Kanemura, Seiki, additional, Wada, Keiko, additional, Sugawara, Yumi, additional, Chen, Chien‐Jen, additional, Chen, Yu, additional, Shin, Aesun, additional, Wang, Renwei, additional, Ahn, Yoon‐Ok, additional, Shin, Min‐Ho, additional, Ahsan, Habibul, additional, Boffetta, Paolo, additional, Chia, Kee Seng, additional, Qiao, You‐Lin, additional, Rothman, Nathaniel, additional, Zheng, Wei, additional, Inoue, Manami, additional, Kang, Daehee, additional, and Matsuo, Keitaro, additional
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- 2023
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- View/download PDF
127. Opium use and risk of colorectal cancer: a multi-center case-referent study in Iran
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Hadji, Maryam, primary, Marzban, Maryam, additional, Rashidian, Hamideh, additional, Naghibzadeh-Tahami, Ahmad, additional, Gholipour, Mahin, additional, Mohebbi, Elham, additional, Safari-Faramani, Roya, additional, Seyyedsalehi, Monireh Sadat, additional, Hosseini, Bayan, additional, Alizadeh-Navaei, Reza, additional, Rezaianzadeh, Abbas, additional, Moradi, Abdolvahab, additional, ShahidSales, Soodabeh, additional, Najafi, Farid, additional, Moazed, Vahid, additional, Haghdoost, Ali Akbar, additional, Rahimi-Movaghar, Afarin, additional, Etemadi, Arash, additional, Malekzadeh, Reza, additional, Boffetta, Paolo, additional, Weiderpass, Elisabete, additional, Kamangar, Farin, additional, Zendehdel, Kazem, additional, and Pukkala, Eero, additional
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- 2023
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- View/download PDF
128. Lung Cancer Risk Prediction Models for Asian Ever-Smokers
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Yang, Jae Jeong, primary, Wen, Wanqing, additional, Zahed, Hana, additional, Zheng, Wei, additional, Lan, Qing, additional, Abe, Sarah K., additional, Rahman, Md. Shafiur, additional, Islam, Md. Rashedul, additional, Saito, Eiko, additional, Gupta, Prakash C., additional, Tamakoshi, Akiko, additional, Koh, Woon-Puay, additional, Gao, Yu-Tang, additional, Sakata, Ritsu, additional, Tsuji, Ichiro, additional, Malekzadeh, Reza, additional, Sugawara, Yumi, additional, Kim, Jeongseon, additional, Ito, Hidemi, additional, Nagata, Chisato, additional, You, San-Lin, additional, Park, Sue K., additional, Yuan, Jian-Min, additional, Shin, Myung-Hee, additional, Kweon, Sun-Seog, additional, Yi, Sang-Wook, additional, Pednekar, Mangesh S., additional, Kimura, Takashi, additional, Cai, Hui, additional, Lu, Yukai, additional, Etemadi, Arash, additional, Kanemura, Seiki, additional, Wada, Keiko, additional, Chen, Chien-Jen, additional, Shin, Aesun, additional, Wang, Renwei, additional, Ahn, Yoon-Ok, additional, Shin, Min-Ho, additional, Ohrr, Heechoul, additional, Sheikh, Mahdi, additional, Blechter, Batel, additional, Ahsan, Habibul, additional, Boffetta, Paolo, additional, Chia, Kee Seng, additional, Matsuo, Keitaro, additional, Qiao, You-Lin, additional, Rothman, Nathaniel, additional, Inoue, Manami, additional, Kang, Daehee, additional, Robbins, Hilary A., additional, and Shu, Xiao-Ou, additional
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- 2023
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129. SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers
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De Maria, Luigi, primary, Delvecchio, Giuseppe, additional, Sponselli, Stefania, additional, Cafaro, Francesco, additional, Caputi, Antonio, additional, Giannelli, Gianmarco, additional, Stefanizzi, Pasquale, additional, Bianchi, Francesco Paolo, additional, Stufano, Angela, additional, Tafuri, Silvio, additional, Lovreglio, Piero, additional, Boffetta, Paolo, additional, and Vimercati, Luigi, additional
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- 2023
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- View/download PDF
130. Smoke Exposure Associated with Higher Urinary Benzene Biomarker Muconic Acid (MUCA) in Golestan Cohort Study Participants
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Bhandari, Deepak, primary, Zhu, Yuyang, additional, Zhang, Can, additional, Zhu, Wanzhe, additional, Alexandridis, Apostolos, additional, Etemadi, Arash, additional, Freedman, Neal D., additional, Chang, Cindy, additional, Abnet, Christian C., additional, Dawsey, Sanford M., additional, Inoue-Choi, Maki, additional, Poustchi, Hossein, additional, Pourshams, Akram, additional, Boffetta, Paolo, additional, Malekzadeh, Reza, additional, and Blount, Benjamin, additional
- Published
- 2023
- Full Text
- View/download PDF
131. Exposure to polycyclic aromatic hydrocarbons, volatile organic compounds, and tobacco-specific nitrosamines and incidence of esophageal cancer
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Etemadi, Arash, primary, Poustchi, Hossein, additional, Chang, Cindy M, additional, Calafat, Antonia M, additional, Blount, Benjamin C, additional, Bhandari, Deepak, additional, Wang, Lanqing, additional, Roshandel, Gholamreza, additional, Alexandridis, Apostolos, additional, Botelho, Julianne Cook, additional, Xia, Baoyun, additional, Wang, Yuesong, additional, Sosnoff, Connie S, additional, Feng, Jun, additional, Nalini, Mahdi, additional, Khoshnia, Masoud, additional, Pourshams, Akram, additional, Sotoudeh, Masoud, additional, Gail, Mitchell H, additional, Dawsey, Sanford M, additional, Kamangar, Farin, additional, Boffetta, Paolo, additional, Brennan, Paul, additional, Abnet, Christian C, additional, Malekzadeh, Reza, additional, and Freedman, Neal D, additional
- Published
- 2023
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- View/download PDF
132. Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies
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Wan, Wenxin, primary, Peters, Susan, additional, Portengen, Lützen, additional, Olsson, Ann, additional, Schüz, Joachim, additional, Ahrens, Wolfgang, additional, Schejbalova, Miriam, additional, Boffetta, Paolo, additional, Behrens, Thomas, additional, Brüning, Thomas, additional, Kendzia, Benjamin, additional, Consonni, Dario, additional, Demers, Paul A, additional, Fabiánová, Eleonóra, additional, Fernández-Tardón, Guillermo, additional, Field, John K., additional, Forastiere, Francesco, additional, Foretova, Lenka, additional, Guénel, Pascal, additional, Gustavsson, Per, additional, Jöckel, Karl-Heinz, additional, Karrasch, Stefan, additional, Landi, Maria Teresa, additional, Lissowska, Jolanta, additional, Barul, Christine, additional, Mates, Dana, additional, McLaughlin, John R., additional, Merletti, Franco, additional, Migliore, Enrica, additional, Richiardi, Lorenzo, additional, Pándics, Tamás, additional, Pohlabeln, Hermann, additional, Siemiatycki, Jack, additional, Świątkowska, Beata, additional, Wichmann, Heinz-Erich, additional, Zaridze, David, additional, Ge, Calvin, additional, Straif, Kurt, additional, Kromhout, Hans, additional, and Vermeulen, Roel, additional
- Published
- 2023
- Full Text
- View/download PDF
133. Response to : ‘Are children more vulnerable to mesothelioma than adults? A comparison of mesothelioma risk among children and adults exposed non-occupationally to blue asbestos at Wittenoom’ by Reid et al
- Author
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Farioli, Andrea, Boffetta, Paolo, Curti, Stefania, Garzaro, Giacomo, La Vecchia, Carlo, Mattioli, Stefano, Spatari, Giovanna, and Violante, Francesco Saverio
- Published
- 2019
134. How to Integrate Personalized Medicine into Prevention? Recommendations from the Personalized Prevention of Chronic Diseases (PRECeDI) Consortium
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Boccia, Stefania, Pastorino, Roberta, Ricciardi, Walter, Ádány, Róza, Barnhoorn, Floris, Boffetta, Paolo, Cornel, Martina C., De Vito, Corrado, Gray, Muir, Jani, Anant, Lang, Michael, Roldan, Jim, Rosso, Annalisa, Sánchez, José Manuel, Van Dujin, Cornelia M., Van El, Carla G., Villari, Paolo, and Zawati, Ma’n H.
- Published
- 2019
135. The application of six dietary scores to a Middle Eastern population : a comparative analysis of mortality in a prospective study
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Hashemian, Maryam, Farvid, Maryam S., Poustchi, Hossein, Murphy, Gwen, Etemadi, Arash, Hekmatdoost, Azita, Kamangar, Farin, Sheikh, Mahdi, Pourshams, Akram, Sepanlou, Sadaf G., Malekshah, Akbar Fazeltabar, Khoshnia, Masoud, Gharavi, Abdolsamad, Brennan, Paul J., Boffetta, Paolo, Dawsey, Sanford M., Reedy, Jill, Subar, Amy F., Abnet, Christian C., and Malekzadeh, Reza
- Published
- 2019
136. Secondhand Tobacco Smoke Exposure and Lung Adenocarcinoma In Situ/Minimally Invasive Adenocarcinoma (AIS/MIA)
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Kim, Claire H, Lee, Yuan-Chin Amy, Hung, Rayjean J, Boffetta, Paolo, Xie, Dong, Wampfler, Jason A, Cote, Michele L, Chang, Shen-Chih, Ugolini, Donatella, Neri, Monica, Le Marchand, Loic, Schwartz, Ann G, Morgenstern, Hal, Christiani, David C, Yang, Ping, and Zhang, Zuo-Feng
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Lung ,Clinical Research ,Tobacco Smoke and Health ,Lung Cancer ,Cancer ,Tobacco ,Prevention ,Respiratory ,Good Health and Well Being ,Adenocarcinoma ,Adenocarcinoma of Lung ,Aged ,Aged ,80 and over ,Case-Control Studies ,Female ,Humans ,Lung Neoplasms ,Male ,Middle Aged ,Risk Factors ,Tobacco Smoke Pollution ,Medical and Health Sciences ,Epidemiology ,Biomedical and clinical sciences ,Health sciences - Abstract
The aim of this study was to estimate the effect of exposure to secondhand tobacco smoke on the incidence of lung adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA). Data from seven case-control studies participating in the International Lung Cancer Consortium (ILCCO) were pooled, resulting in 625 cases of AIS/MIA and 7,403 controls, of whom 170 cases and 3,035 controls were never smokers. Unconditional logistic regression was used to estimate adjusted ORs (ORadj) and 95% confidence intervals (CI), controlling for age, sex, race, smoking status (ever/never), and pack-years of smoking. Study center was included in the models as a random-effects intercept term. Ever versus never exposure to secondhand tobacco smoke was positively associated with AIS/MIA incidence in all subjects (ORadj = 1.48; 95% CI, 1.14-1.93) and in never smokers (ORadj = 1.45; 95% CI, 1.00-2.12). There was, however, appreciable heterogeneity of ORadj across studies (P = 0.01), and the pooled estimates were largely influenced by one large study (40% of all cases and 30% of all controls). These findings provide weak evidence for an effect of secondhand tobacco smoke exposure on AIS/MIA incidence. Further studies are needed to assess the impact of secondhand tobacco smoke exposure using the newly recommended classification of subtypes of lung adenocarcinoma.
- Published
- 2015
137. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
- Author
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Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, De Vivo, Immaculata, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John KC, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, and Davis, Faith G
- Subjects
Tobacco ,Clinical Research ,Urologic Diseases ,Lung ,Genetics ,Rare Diseases ,Lung Cancer ,Human Genome ,Hematology ,Cancer ,Tobacco Smoke and Health ,Prevention ,Lymphoma ,Adult ,Aged ,Asian People ,Bone Neoplasms ,Female ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Kidney Neoplasms ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Lung Neoplasms ,Lymphoma ,Large B-Cell ,Diffuse ,Male ,Middle Aged ,Neoplasms ,Osteosarcoma ,Polymorphism ,Single Nucleotide ,Smoking ,Testicular Neoplasms ,Tissue Array Analysis ,Urinary Bladder Neoplasms ,White People ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundStudies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.MethodsBetween 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.ResultsGWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.ConclusionOur results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
- Published
- 2015
138. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.
- Author
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Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, De Vivo, Immaculata, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John KC, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, and Davis, Faith G
- Subjects
Humans ,Neoplasms ,Osteosarcoma ,Bone Neoplasms ,Testicular Neoplasms ,Lung Neoplasms ,Kidney Neoplasms ,Genetic Predisposition to Disease ,Tissue Array Analysis ,Smoking ,Polymorphism ,Single Nucleotide ,Adult ,Aged ,Middle Aged ,Asian Continental Ancestry Group ,European Continental Ancestry Group ,Female ,Male ,Urinary Bladder Neoplasms ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Lymphoma ,Large B-Cell ,Diffuse ,Genome-Wide Association Study ,Polymorphism ,Single Nucleotide ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Lymphoma ,Large B-Cell ,Diffuse ,Oncology And Carcinogenesis ,Oncology & Carcinogenesis ,Oncology and Carcinogenesis - Abstract
BackgroundStudies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.MethodsBetween 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.ResultsGWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.ConclusionOur results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
- Published
- 2015
139. Beta-blockers have no impact on survival in pancreatic ductal adenocarcinoma prior to cancer diagnosis
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Yang, Anthony, Zylberberg, Haley M., Rustgi, Sheila D., Amin, Sunil P., Bar-Mashiah, Ariel, Boffetta, Paolo, and Lucas, Aimee L.
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- 2021
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- View/download PDF
140. Letter in response to the article 'The global prevalence of musculoskeletal disorders among operating room personnel: A systematic review and meta-analysis' by Tavakkol et al.
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Clari Marco, Godono Alessandro, Boffetta Paolo, and Dimonte Valerio
- Subjects
Musculoskeletal disorders ,Meta-analysis ,Systematic review ,Operating room nurses ,Public aspects of medicine ,RA1-1270 - Published
- 2021
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- View/download PDF
141. Coffee consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling Project consortium
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Martimianaki, Georgia, Bertuccio, Paola, Alicandro, Gianfranco, Pelucchi, Claudio, Bravi, Francesca, Carioli, Greta, Bonzi, Rossella, Rabkin, Charles S., Liao, Linda M., Sinha, Rashmi, Johnson, Ken, Hu, Jinfu, Palli, Domenico, Ferraroni, Monica, Lunet, Nuno, Morais, Samantha, Tsugane, Shoichiro, Hidaka, Akihisa, Hamada, Gerson Shigueaki, López-Carrillo, Lizbeth, Hernández-Ramírez, Raúl Ulises, Zaridze, David, Maximovitch, Dmitry, Aragonés, Nuria, Martin, Vicente, Ward, Mary H., Vioque, Jesus, Garcia de la Hera, Manoli, Zhang, Zuo-Feng, Kurtz, Robert C., Lagiou, Pagona, Lagiou, Areti, Trichopoulou, Antonia, Karakatsani, Anna, Malekzadeh, Reza, Camargo, M. Constanza, Curado, Maria Paula, Boccia, Stefania, Boffetta, Paolo, Negri, Eva, and La Vecchia, Carlo
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- 2022
- Full Text
- View/download PDF
142. Interaction between occupational exposure to diesel exhaust and tobacco smoking in determining lung cancer risk: a meta-analysis
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Rizzello, Emanuele, Denti Pompiani, Ilaria, Violante, Francesco, and Boffetta, Paolo
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- 2022
- Full Text
- View/download PDF
143. Coffee, tea, caffeine intake, and the risk of cancer in the PLCO cohort
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Hashibe, Mia, Galeone, Carlotta, Buys, Saundra S, Gren, Lisa, Boffetta, Paolo, Zhang, Zuo-Feng, and La Vecchia, Carlo
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Prevention ,Urologic Diseases ,Nutrition ,Cancer ,Clinical Research ,Ovarian Cancer ,Rare Diseases ,Aetiology ,2.2 Factors relating to the physical environment ,Aged ,Caffeine ,Coffee ,Colorectal Neoplasms ,Female ,Humans ,Lung Neoplasms ,Male ,Middle Aged ,Ovarian Neoplasms ,Prospective Studies ,Prostatic Neoplasms ,Risk Factors ,Tea ,coffee ,tea ,caffeine ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
BackgroundThe association between coffee intake, tea intake and cancer has been extensively studied, but associations are not established for many cancers. Previous studies are not consistent on whether caffeine may be the source of possible associations between coffee and cancer risk.MethodsIn the Prostate, Lung, Colorectal, and Ovarian cancer screening trial, of the 97,334 eligible individuals, 10,399 developed cancer. Cancers included were 145 head and neck, 99 oesophageal, 136 stomach, 1137 lung, 1703 breast, 257 endometrial, 162 ovarian, 3037 prostate, 318 kidney, 398 bladder, 103 gliomas, and 106 thyroid.ResultsMean coffee intake was higher in lower education groups, among current smokers, among heavier and longer duration smokers, and among heavier alcohol drinkers. Coffee intake was not associated with the risk of all cancers combined (RR=1.00, 95% confidence interval (CI)=0.96-1.05), whereas tea drinking was associated with a decreased risk of cancer overall (RR=0.95, 95% CI=0.94-0.96 for 1+ cups per day vs
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- 2015
144. Relation of allium vegetables intake with head and neck cancers: Evidence from the INHANCE consortium
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Galeone, Carlotta, Turati, Federica, Zhang, Zuo-Feng, Guercio, Valentina, Tavani, Alessandra, Serraino, Diego, Brennan, Paul, Fabianova, Eleonora, Lissowska, Jola, Mates, Dana, Rudnai, Peter, Shangina, Oxana, Szeszenia-Dabrowska, Neonila, Vaughan, Thomas L, Kelsey, Karl, McClean, Michael, Levi, Fabio, Hayes, Richard B, Purdue, Mark P, Bosetti, Cristina, Brenner, Hermann, Pelucchi, Claudio, Lee, Yuan-Chin Amy, Hashibe, Mia, Boffetta, Paolo, and La Vecchia, Carlo
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Rare Diseases ,Dental/Oral and Craniofacial Disease ,Cancer ,Allium ,Case-Control Studies ,Diet ,Head and Neck Neoplasms ,Humans ,Logistic Models ,Risk Factors ,Vegetables ,Allium vegetables ,Garlic ,Onion ,Food Sciences ,Public Health and Health Services ,Food Science ,Nutrition & Dietetics ,Food sciences ,Nutrition and dietetics - Abstract
ScopeOnly a few studies analyzed the role of allium vegetables with reference to head and neck cancers (HNC), with mixed results. We investigated the potential favorable role of garlic and onion within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium.Methods and resultsWe analyzed pooled individual-level data from eight case-control studies, including 4590 cases and 7082 controls. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between garlic and onion intakes and HNC risk. Compared with no or low garlic use, the ORs of HNC were 0.95 (95% CI 0.71-1.27) for intermediate and 0.74 (95% CI 0.55-0.99) for high garlic use (p for trend = 0.02). The ORs of HNC for increasing categories of onion intake were 0.91 (95% CI 0.68-1.21) for >1 to ≤3 portions per week, and 0.83 (95% CI 0.60-1.13) for >3 portions per week (p for trend = 0.02), as compared to
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- 2015
145. Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
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Edefonti, Valeria, Hashibe, Mia, Parpinel, Maria, Turati, Federica, Serraino, Diego, Matsuo, Keitaro, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Kelsey, Karl, McClean, Michael, Bosetti, Cristina, Galeone, Carlotta, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Amy Lee, Yuan-Chin, Chuang, Shu-Chun, La Vecchia, Carlo, and Decarli, Adriano
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Prevention ,Nutrition ,Dental/Oral and Craniofacial Disease ,Cancer ,Rare Diseases ,Digestive Diseases ,Good Health and Well Being ,Ascorbic Acid ,Case-Control Studies ,Head and Neck Neoplasms ,Humans ,International Agencies ,Italy ,Japan ,Logistic Models ,Risk Factors ,Surveys and Questionnaires ,Switzerland ,United States ,Vitamins ,head and neck cancer ,INHANCE ,laryngeal cancer ,oral and pharyngeal cancer ,vitamin C ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Evidence of associations between single nutrients and head and neck cancer (HNC) is still more limited and less consistent than that for fruit and vegetables. However, clarification of the protective mechanisms of fruit and vegetables is important to our understanding of HNC etiology. We investigated the association between vitamin C intake from natural sources and cancer of the oral cavity/pharynx and larynx using individual-level pooled data from ten case-control studies (5,959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. After harmonization of study-specific exposure information via the residual method, adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models on quintile categories of 'non-alcohol energy-adjusted' vitamin C intake. In the presence of heterogeneity of the estimated ORs among studies, we derived those estimates from generalized linear mixed models. Higher intakes of vitamin C were inversely related to oral and pharyngeal (OR = 0.54, 95% CI: 0.45-0.65, for the fifth quintile category versus the first one, p for trend
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- 2015
146. Associations of Non-Hodgkin Lymphoma (NHL) Risk With Autoimmune Conditions According to Putative NHL Loci
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Wang, Sophia S, Vajdic, Claire M, Linet, Martha S, Slager, Susan L, Voutsinas, Jenna, Nieters, Alexandra, de Sanjose, Silvia, Cozen, Wendy, Alarcón, Graciela S, Martinez-Maza, Otoniel, Brown, Elizabeth E, Bracci, Paige M, Lightfoot, Tracy, Turner, Jennifer, Hjalgrim, Henrik, Spinelli, John J, Zheng, Tongzhang, Morton, Lindsay M, Birmann, Brenda M, Flowers, Christopher R, Paltiel, Ora, Becker, Nikolaus, Holly, Elizabeth A, Kane, Eleanor, Weisenburger, Dennis, Maynadie, Marc, Cocco, Pierluigi, Foretova, Lenka, Staines, Anthony, Davis, Scott, Severson, Richard, Cerhan, James R, Breen, Elizabeth C, Lan, Qing, Brooks-Wilson, Angela, De Roos, Anneclaire J, Smith, Martyn T, Roman, Eve, Boffetta, Paolo, Kricker, Anne, Zhang, Yawei, Skibola, Christine, Chanock, Stephen J, Rothman, Nathaniel, Benavente, Yolanda, Hartge, Patricia, and Smedby, Karin E
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Cancer ,HIV/AIDS ,Autoimmune Disease ,Genetics ,Lymphoma ,Rare Diseases ,Hematology ,Aetiology ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Autoimmune Diseases ,Case-Control Studies ,HLA Antigens ,Humans ,Interleukin-10 ,Lymphoma ,Non-Hodgkin ,Polymorphism ,Single Nucleotide ,Tumor Necrosis Factor-alpha ,autoimmune conditions ,environment ,genetics ,interaction ,human leukocyte antigen ,lymphoma ,non-Hodgkin ,tumor necrosis factor ,lymphoma ,non-Hodgkin ,Mathematical Sciences ,Medical and Health Sciences ,Epidemiology - Abstract
Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as primarily mediated by B-cell or T-cell responses. We constructed unconditional logistic regression models to measure associations between autoimmune conditions and NHL with stratification by genotype. Autoimmune conditions mediated by B-cell responses were associated with increased NHL risk, specifically diffuse large B-cell lymphoma (odds ratio (OR) = 3.11, 95% confidence interval (CI): 2.25, 4.30) and marginal zone lymphoma (OR = 5.80, 95% CI: 3.82, 8.80); those mediated by T-cell responses were associated with peripheral T-cell lymphoma (OR = 2.14, 95% CI: 1.35, 3.38). In the presence of the rs1800629 AG/AA genotype, B-cell-mediated autoimmune conditions increased NHL risk (OR = 3.27, 95% CI: 2.07, 5.16; P-interaction = 0.03) in comparison with the GG genotype (OR = 1.82, 95% CI: 1.31, 2.53). This interaction was consistent across major B-cell NHL subtypes, including marginal zone lymphoma (P-interaction = 0.02) and follicular lymphoma (P-interaction = 0.04).
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- 2015
147. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case‐control studies from 27 countries
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Conway, David I, Brenner, Darren R, McMahon, Alex D, Macpherson, Lorna MD, Agudo, Antonio, Ahrens, Wolfgang, Bosetti, Cristina, Brenner, Hermann, Castellsague, Xavier, Chen, Chu, Curado, Maria Paula, Curioni, Otávio A, Dal Maso, Luigino, Daudt, Alexander W, de Gois Filho, José F, D'Souza, Gypsyamber, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Gillison, Maura, Hayes, Richard B, Healy, Claire M, Herrero, Rolando, Holcatova, Ivana, Jayaprakash, Vijayvel, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Sergio, La Vecchia, Carlo, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Tatiana V, Mates, Dana, Matos, Elena, McClean, Michael, Menezes, Ana M, Menvielle, Gwenn, Merletti, Franco, Morgenstern, Hal, Moysich, Kirsten, Müller, Heiko, Muscat, Joshua, Olshan, Andrew F, Purdue, Mark P, Ramroth, Heribert, Richiardi, Lorenzo, Rudnai, Peter, Schantz, Stimson, Schwartz, Stephen M, Shangina, Oxana, Simonato, Lorenzo, Smith, Elaine, Stucker, Isabelle, Sturgis, Erich M, Szeszenia‐Dabrowska, Neonila, Talamini, Renato, Thomson, Peter, Vaughan, Thomas L, Wei, Qingyi, Winn, Deborah M, Wunsch‐Filho, Victor, Yu, Guo‐Pei, Zhang, Zuo‐Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Chuang, Shu‐Chun, Ghodrat, Marianoosh, Lee, Yuan‐Chin Amy, Hashibe, Mia, and Brennan, Paul
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Behavioral and Social Science ,Tobacco ,Dental/Oral and Craniofacial Disease ,Tobacco Smoke and Health ,Cancer ,Prevention ,Substance Misuse ,Basic Behavioral and Social Science ,Reduced Inequalities ,Good Health and Well Being ,Alcohol Drinking ,Case-Control Studies ,Education ,Female ,Follow-Up Studies ,Global Health ,Head and Neck Neoplasms ,Humans ,Income ,Male ,Meta-Analysis as Topic ,Middle Aged ,Prognosis ,Risk Factors ,Smoking ,Socioeconomic Factors ,head and neck cancer ,socioeconomic inequalities ,epidemiology ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR = 2.50; 95% CI = 2.02 - 3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR = 1.61; 95% CI = 1.13 - 2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels.
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- 2015
148. Folate intake and the risk of oral cavity and pharyngeal cancer: A pooled analysis within the International Head and Neck Cancer Epidemiology Consortium
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Galeone, Carlotta, Edefonti, Valeria, Parpinel, Maria, Leoncini, Emanuele, Matsuo, Keitaro, Talamini, Renato, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Jayaprakash, Vijayvel, Moysich, Kirsten, Zhang, Zuo‐Feng, Morgenstern, Hal, Levi, Fabio, Bosetti, Cristina, Kelsey, Karl, McClean, Michael, Schantz, Stimson, Yu, Guo‐Pei, Boffetta, Paolo, Lee, Yuan‐Chin Amy, Hashibe, Mia, La Vecchia, Carlo, and Boccia, Stefania
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Digestive Diseases ,Cancer ,Prevention ,Nutrition ,Complementary and Integrative Health ,Dental/Oral and Craniofacial Disease ,Good Health and Well Being ,Administration ,Oral ,Anticarcinogenic Agents ,Case-Control Studies ,Dietary Supplements ,Folic Acid ,Humans ,Mouth Neoplasms ,Pharyngeal Neoplasms ,Risk ,oral cancer ,folate intake ,diet ,epidemiology ,risk factor ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
There are suggestions of an inverse association between folate intake and serum folate levels and the risk of oral cavity and pharyngeal cancers (OPCs), but most studies are limited in sample size, with only few reporting information on the source of dietary folate. Our study aims to investigate the association between folate intake and the risk of OPC within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. We analyzed pooled individual-level data from ten case-control studies participating in the INHANCE consortium, including 5,127 cases and 13,249 controls. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated for the associations between total folate intake (natural, fortification and supplementation) and natural folate only, and OPC risk. We found an inverse association between total folate intake and overall OPC risk (the adjusted OR for the highest vs. the lowest quintile was 0.65, 95% CI: 0.43-0.99), with a stronger association for oral cavity (OR = 0.57, 95% CI: 0.43-0.75). A similar inverse association, though somewhat weaker, was observed for folate intake from natural sources only in oral cavity cancer (OR = 0.64, 95% CI: 0.45-0.91). The highest OPC risk was observed in heavy alcohol drinkers with low folate intake as compared to never/light drinkers with high folate (OR = 4.05, 95% CI: 3.43-4.79); the attributable proportion (AP) owing to interaction was 11.1% (95% CI: 1.4-20.8%). Lastly, we reported an OR of 2.73 (95% CI:2.34-3.19) for those ever tobacco users with low folate intake, compared with nevere tobacco users and high folate intake (AP of interaction =10.6%, 95% CI: 0.41-20.8%). Our project of a large pool of case-control studies supports a protective effect of total folate intake on OPC risk.
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- 2015
149. Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium
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Toporcov, Tatiana Natasha, Znaor, Ariana, Zhang, Zuo-Feng, Yu, Guo-Pei, Winn, Deborah M, Wei, Qingyi, Vilensky, Marta, Vaughan, Thomas, Thomson, Peter, Talamini, Renato, Szeszenia-Dabrowska, Neonila, Sturgis, Erich M, Smith, Elaine, Shangina, Oxana, Schwartz, Stephen M, Schantz, Stimson, Rudnai, Peter, Richiardi, Lorenzo, Ramroth, Heribert, Purdue, Mark P, Olshan, Andrew F, Eluf-Neto, José, Muscat, Joshua, Moyses, Raquel Ajub, Morgenstern, Hal, Menezes, Ana, McClean, Michael, Matsuo, Keitaro, Mates, Dana, Macfarlane, Tatiana V, Lissowska, Jolanta, Levi, Fabio, Lazarus, Philip, La Vecchia, Carlo, Lagiou, Pagona, Koifman, Sergio, Kjaerheim, Kristina, Kelsey, Karl, Holcatova, Ivana, Herrero, Rolando, Healy, Claire, Hayes, Richard B, Franceschi, Silvia, Fernandez, Leticia, Fabianova, Eleonora, Daudt, Alexander W, Curioni, Otávio Alberto, Maso, Luigino Dal, Curado, Maria Paula, Conway, David I, Chen, Chu, Castellsague, Xavier, Canova, Cristina, Cadoni, Gabriella, Brennan, Paul, Boccia, Stefania, Antunes, José Leopoldo Ferreira, Ahrens, Wolfgang, Agudo, Antonio, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, and Filho, Victor Wünsch
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Prevention ,Cancer ,Clinical Research ,Tobacco ,Tobacco Smoke and Health ,Dental/Oral and Craniofacial Disease ,Rare Diseases ,Digestive Diseases ,Aging ,Good Health and Well Being ,Adult ,Age Factors ,Alcohol Drinking ,Case-Control Studies ,Female ,Genetic Predisposition to Disease ,Head and Neck Neoplasms ,Humans ,Incidence ,Male ,Middle Aged ,Odds Ratio ,Registries ,Risk Factors ,Sex Factors ,Smoking ,Head and neck neoplasms ,adult ,smoking ,alcohol drinking ,diet ,Statistics ,Public Health and Health Services ,Epidemiology - Abstract
BackgroundIncreasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients.MethodsWe pooled data from 25 case-control studies and conducted separate analyses for adults ≤ 45 years old ('young adults', 2010 cases and 4042 controls) and >45 years old ('older adults', 17700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs).ResultsThe young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, = 19.9% (95% CI=9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking=5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR=2.27 (95% CI=1.26, 4.10)], but not in the older adults [OR=1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2.41%, 5.80%) in older adults.ConclusionsDifferences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.
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- 2015
150. A genome-wide association study of marginal zone lymphoma shows association to the HLA region.
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Vijai, Joseph, Wang, Zhaoming, Berndt, Sonja I, Skibola, Christine F, Slager, Susan L, de Sanjose, Silvia, Melbye, Mads, Glimelius, Bengt, Bracci, Paige M, Conde, Lucia, Birmann, Brenda M, Wang, Sophia S, Brooks-Wilson, Angela R, Lan, Qing, de Bakker, Paul IW, Vermeulen, Roel CH, Portlock, Carol, Ansell, Stephen M, Link, Brian K, Riby, Jacques, North, Kari E, Gu, Jian, Hjalgrim, Henrik, Cozen, Wendy, Becker, Nikolaus, Teras, Lauren R, Spinelli, John J, Turner, Jenny, Zhang, Yawei, Purdue, Mark P, Giles, Graham G, Kelly, Rachel S, Zeleniuch-Jacquotte, Anne, Ennas, Maria Grazia, Monnereau, Alain, Bertrand, Kimberly A, Albanes, Demetrius, Lightfoot, Tracy, Yeager, Meredith, Chung, Charles C, Burdett, Laurie, Hutchinson, Amy, Lawrence, Charles, Montalvan, Rebecca, Liang, Liming, Huang, Jinyan, Ma, Baoshan, Villano, Danylo J, Maria, Ann, Corines, Marina, Thomas, Tinu, Novak, Anne J, Dogan, Ahmet, Liebow, Mark, Thompson, Carrie A, Witzig, Thomas E, Habermann, Thomas M, Weiner, George J, Smith, Martyn T, Holly, Elizabeth A, Jackson, Rebecca D, Tinker, Lesley F, Ye, Yuanqing, Adami, Hans-Olov, Smedby, Karin E, De Roos, Anneclaire J, Hartge, Patricia, Morton, Lindsay M, Severson, Richard K, Benavente, Yolanda, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Diver, W Ryan, Vajdic, Claire M, Armstrong, Bruce K, Kricker, Anne, Zheng, Tongzhang, Holford, Theodore R, Severi, Gianluca, Vineis, Paolo, Ferri, Giovanni M, Ricco, Rosalia, Miligi, Lucia, Clavel, Jacqueline, Giovannucci, Edward, Kraft, Peter, Virtamo, Jarmo, Smith, Alex, Kane, Eleanor, Roman, Eve, Chiu, Brian CH, Fraumeni, Joseph F, Wu, Xifeng, Cerhan, James R, Offit, Kenneth, and Chanock, Stephen J
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Humans ,Membrane Glycoproteins ,Computational Biology ,Major Histocompatibility Complex ,Genotype ,Polymorphism ,Single Nucleotide ,European Continental Ancestry Group ,Lymphoma ,B-Cell ,Marginal Zone ,Genome-Wide Association Study ,Butyrophilins ,Polymorphism ,Single Nucleotide ,Lymphoma ,B-Cell ,Marginal Zone - Abstract
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
- Published
- 2015
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