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443 results on '"Bonaduce, D."'

104. Myocardial hypertrophy and left ventricular function in systemic hypertension: An echo-Doppler study

Author

Conforti, G., Breglio, R., Morgano, G., Montemurro, M. V., Arrichiello, P., Tesorio, M., Mario Petretta, Bonaduce, D., Conforti, G, Breglio, R, Morgano, G, Montemurro, Mv, Arrichiello, P, Tesorio, M, Petretta, Mario, and Bonaduce, Domenico

Subjects
Adult, Cardiomegaly, Comparative Study, Echocardiography, English Abstract, Female, Heart, Human, Hypertension, Male, Middle Age, Radionuclide Angiography, adult, clinical article, echocardiography, female, heart left ventricle hypertrophy, heart left ventricle performance, human, hypertension, male, article, cardiomegaly, comparative study, heart, pathophysiology, scintiangiography

106. Coronary heart disease and menopause,LA CARDIOPATIA ISCHEMICA IN MENOPAUSA

Author

Mario Petretta, Rotondi, F., Capozzi, E., Cavallaro, V., Bianchi, V., Giano, G., Ambrosini, V., Lanzillo, D., Bonaduce, D., Petretta, Mario, F., Rotondi, E., Capozzi, V., Cavallaro, V., Bianchi, G., Giano, V., Ambrosini, T., Lanzillo, and D. B. o. n. a. d. u. c., E.

Subjects
Angina Pectoris, Coronary Disease, English Abstract, Female, Human, Menopause, Middle Age, estrogen, angina pectoris, angiocardiography, article, cerebrovascular disease, coronary artery disease, female, human, menopause, prognosi

108. Prediction of recovery of left ventricular dysfunction after acute myocardial infarction: Comparison between 99mTc-sestamibi cardiac tomography and low-dose dobutamine echocardiography

Author

Spinelli, L., Petretta, M., Cuocolo, A., Nicolai, E., Wanda ACAMPA, Vicario, L., Bonaduce, D., Spinelli, L, Petretta, Mario, Cuocolo, A, Nicolai, E, Acampa, Wanda, Vicario, Ml, Bonaduce, Domenico, Cuocolo, Alberto, and Vicario, L

Subjects
Male, Technetium Tc 99m Sestamibi, Tomography, Emission-Computed, Single-Photon, Cardiotonic Agents, Left ventricular function, Angioplasty, Myocardial Infarction, Middle Aged, Prognosis, Myocardial Contraction, Ventricular Function, Left, ROC Curve, Echocardiography, Dobutamine, Acute Disease, Multivariate Analysis, Myocardial Revascularization, Humans, Female, Radiopharmaceuticals
Abstract

The aim of this study was to evaluate the role of 99mTc-sestamibi cardiac imaging and dobutamine echocardiography in detecting myocardial viability early after acute myocardial infarction. METHODS: Forty-nine patients (mean age 52 +/- 10 y) underwent coronary angiography, low-dose dobutamine echocardiography, radionuclide angiography and rest 99mTc-sestamibi imaging within 10 d after myocardial infarction. Of these patients, 19 were revascularized and 30 were treated medically. Resting echocardiogram and radionuclide angiography were repeated 8 mo later to evaluate segmental functional recovery and changes in left ventricular (LV) ejection fraction, respectively. RESULTS: In revascularized patients, 61 of 108 akinetic or dyskinetic segments showed functional recovery. In these patients, sensitivity in predicting segmental functional recovery was 87% for sestamibi imaging and 66% for dobutamine echocardiography (P < 0.001), whereas specificity and accuracy were comparable. Sestamibi activity (> or =55% of peak) was the strongest predictor of segmental functional recovery (P < 0.001) and of LV ejection fraction improvement > or =5% (P < 0.01) after revascularization. In medically treated patients, 60 of 149 akinetic or dyskinetic segments showed functional recovery. In these patients, the majority (94%) of segments with contractile reserve on dobutamine were viable on sestamibi imaging and 86% of them improved function at follow-up. Functional recovery was poor in segments without contractile reserve either with (38%) or without (62%) preserved sestamibi uptake. Inotropic response was the best predictor of segmental (P < 0.001) and global (P < 0.01) LV functional improvement in medically treated patients. CONCLUSION: Dobutamine echocardiography predicts spontaneous functional recovery after acute myocardial infarction. However, sestamibi imaging is useful to identify patients with dysfunctional myocardium without contractile reserve who may benefit from coronary revascularization.

112. Mechanisms underlying pulmonary hypertension by hypoxemia

Author

Condorelli, M., Rengo, F., Bruno Trimarco, Bonaduce, D., Iodice, F., Piscione, F., Vigorito, C., Marone, G., Condorelli, M, Rengo, Franco, Trimarco, Bruno, Bonaduce, Domenico, Iodice, F, Piscione, Federico, Vigorito, Carlo, and Marone, Gianni

Subjects
hypoxemia, right heart failure, pulmonary hypertension

123. Prediction of recovery of left ventricular dysfunction after acute myocardial infarction: Comparison between Tc-99m-sestamibi cardiac tomography and low-dose dobutamine echocardiography

Author

Spinelli, L., Mario Petretta, Cuocolo, A., Nicolai, E., Acampa, W., Vicario, L., and Bonaduce, D.

Subjects
contractile function, Tc-99m sestamibi, myocardial viability, dobutamine echocardiography
Abstract

The aim of this study was to evaluate the role of Tc-99m-sestamibi cardiac imaging and dobutamine echocardiography in detecting myocardial viability early after acute myocardial infarction. Methods: Forty-nine patients (mean age 52 +/- 10 y) underwent coronary angiography, low-dose dobutamine echocardiography, radionuclide angiography and rest Tc-99m-sestamibi imaging within 10 d after myocardial infarction. Of these patients, 19 were revascularized and 30 were treated medically. Resting echocardiogram and radionuclide angiography were repeated 8 mo later to evaluate segmental functional recovery and changes in left ventricular (LV) ejection fraction, respectively. Results: In revascularized patients, 61 of 108 akinetic or dyskinetic segments showed functional recovery. In these patients, sensitivity in predicting segmental functional recovery was 87% for sestamibi imaging and 66% for dobutamine echocardiography (P < 0.001), whereas specificity and accuracy were comparable. Sestamibi activity (greater than or equal to 55% of peak) was the strongest predictor of segmental functional recovery (P < 0.001) and of LV ejection fraction improvement greater than or equal to 5% (P < 0.01) after revascularization. In medically treated patients, 60 of 149 akinetic or dyskinetic segments showed functional recovery. In these patients, the majority (94%) of segments with contractile reserve on dobutamine were viable on sestamibi imaging and 86% of them improved function at follow-up. Functional recovery was poor in segments without contractile reserve either with (38%) or without (62%) preserved sestamibi uptake. Inotropic response was the best predictor of segmental (P < 0.001) and global (P < 0.01) LV functional improvement in medically treated patients. Conclusion: Dobutamine echocardiography predicts spontaneous functional recovery after acute myocardial infarction. However, sestamibi imaging is useful to identify patients with dysfunctional myocardium without contractile reserve who may benefit from coronary revascularization.

148. Left ventricular remodeling and function after myocardial infarction

Author

Bonaduce, D., Mario Petretta, Bianchi, V., Morgano, G., Condorelli, M., Bonaduce, Domenico, Petretta, Mario, V., Bianchi, G., Morgano, and Condorelli, Mario

Subjects
alteplase, captopril, dipeptidyl carboxypeptidase inhibitor, enalapril, glyceryl trinitrate, magnesium, streptokinase, drug effect, drug safety, fibrinolytic therapy, heart infarction, heart left ventricle hypertrophy, heart left ventricle volume, heart muscle necrosis, heart perfusion, human, intravenous drug administration, mortality, oral drug administration, review
Abstract

After myocardial infarction, perfusion of the infarct-related artery during the healing phase may be important in preventing infarct expansion and subsequent left ventricular dilation. Observations from thrombolytic trials in which therapy was administered beyond the critical time for myocardial salvage support the importance of patency of the infarct-related vessel. Left ventricular remodeling after MI can be influenced by other interventions, such as nitrates and angiotensin-converting enzyme inhibitors.

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