Search

Your search keyword '"Borén, Jan"' showing total 1,283 results
Start Over Author "Borén, Jan"
1,283 results on '"Borén, Jan"'

108. The spoils of war and the long-term spoiling of health conditions of entire nations

Author

Navarese, Eliano P., primary, Grzelakowska, Klaudyna, additional, Mangini, Francesco, additional, Kubica, Jacek, additional, Banach, Maciej, additional, Benn, Marianne, additional, Binder, Christoph J., additional, Borén, Jan, additional, Catapano, Alberico, additional, Kronenberg, Florian, additional, Mallat, Ziad, additional, Moulin, Philippe, additional, Öörni, Katariina, additional, Ray, Kausik K., additional, Roeters van Lennep, Jeanine E., additional, Romeo, Stefano, additional, Tokgozoglu, Lale, additional, von Eckardstein, Arnold, additional, Zambon, Alberto, additional, and Raggi, Paolo, additional

Published
2022
Full Text
View/download PDF

109. Role of endogenous incretins in the regulation of postprandial lipoprotein metabolism

Author

Taskinen, Marja-Riitta, primary, Matikainen, Niina, additional, Björnson, Elias, additional, Söderlund, Sanni, additional, Ainola, Mari, additional, Hakkarainen, Antti, additional, Lundbom, Nina, additional, Sihlbom, Carina, additional, Thorsell, Annika, additional, Andersson, Linda, additional, Adiels, Martin, additional, Hartmann, Bolette, additional, Deacon, Carolyn F, additional, Holst, Jens J, additional, Packard, Chris J, additional, and Borén, Jan, additional

Published
2022
Full Text
View/download PDF

112. Role of endogenous incretins in the regulation of postprandial lipoprotein metabolism

Author

Taskinen, Marja-Riitta, Matikainen, Niina, Björnson, Elias, Söderlund, Sanni, Ainola, Mari, Hakkarainen, Antti, Lundbom, Nina, Sihlbom, Carina, Thorsell, Annika, Andersson, Linda, Adiels, Martin, Hartmann, Bolette, Deacon, Carolyn F., Holst, Jens J, Packard, Chris J, Borén, Jan, Taskinen, Marja-Riitta, Matikainen, Niina, Björnson, Elias, Söderlund, Sanni, Ainola, Mari, Hakkarainen, Antti, Lundbom, Nina, Sihlbom, Carina, Thorsell, Annika, Andersson, Linda, Adiels, Martin, Hartmann, Bolette, Deacon, Carolyn F., Holst, Jens J, Packard, Chris J, and Borén, Jan

Abstract

Objective: Incretins are known to influence lipid metabolism in the intestine when administered as pharmacologic agents. The aggregate influence of endogenous incretins on chylomicron production and clearance is less clear, particularly in light of opposing effects of co-secreted hormones. Here, we tested the hypothesis that physiological levels of incretins may impact on production or clearances rates of chylomicrons and VLDL.Design and methods: A group of 22 overweight/obese men was studied to determine associations between plasma levels of glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) and glucose-dependent insulinotropic polypeptide (GIP) after a fat-rich meal and the production and clearance rates of apoB48- and apoB100-containing triglyceride-rich lipoproteins. Subjects were stratified by above- and below-median incretin response (area under the curve).Results: Stratification yielded subgroups that differed about two-fold in incretin response. There were neither differences in apoB48 production rates in chylomicrons or VLDL fractions nor in apoB100 or triglyceride kinetics in VLDL between men with above- vs below-median incretin responses. The men with above-median GLP-1 and GLP-2 responses exhibited higher postprandial plasma and chylomicron triglyceride levels, but this could not be related to altered kinetic parameters. No differences were found between incretin response subgroups and particle clearance rates.Conclusion: We found no evidence for a regulatory effect of endogenous incretins on contemporaneous chylomicron or VLDL metabolism following a standardised fat-rich meal. The actions of incretins at pharmacological doses may not be reflected at physiological levels of these hormones.

Published
2022

113. The spoils of war and the long-term spoiling of health conditions of entire nations

Author

Navarese, Eliano P., Grzelakowska, Klaudyna, Mangini, Francesco, Kubica, Jacek, Banach, Maciej, Benn, Marianne, Binder, Christoph J., Borén, Jan, Catapano, Alberico, Kronenberg, Florian, Mallat, Ziad, Moulin, Philippe, Öörni, Katariina, Ray, Kausik K., Roeters van Lennep, Jeanine E., Romeo, Stefano, Tokgozoglu, Lale, von Eckardstein, Arnold, Zambon, Alberto, Raggi, Paolo, Navarese, Eliano P., Grzelakowska, Klaudyna, Mangini, Francesco, Kubica, Jacek, Banach, Maciej, Benn, Marianne, Binder, Christoph J., Borén, Jan, Catapano, Alberico, Kronenberg, Florian, Mallat, Ziad, Moulin, Philippe, Öörni, Katariina, Ray, Kausik K., Roeters van Lennep, Jeanine E., Romeo, Stefano, Tokgozoglu, Lale, von Eckardstein, Arnold, Zambon, Alberto, and Raggi, Paolo

Abstract

The healthcare system of Ukraine was already suffering from several shortfalls before February 2022, but the war of aggression started by the Russian leadership is poised to inflict a further severe blow that will have long-lasting consequences for the health of all Ukrainians. In pre-war Ukraine, noncommunicable diseases (NCDs) contributed to 91% of deaths, especially cardiovascular diseases (67%). Ukrainians have a high prevalence of risk factors for NCDs ranking among the highest levels reported by the World Health Organization (WHO) in the European (EU) Region. Cardiovascular disease is one of the key health risks for the conflict-affected Ukrainian population due to significant limitations in access to health care and interruptions in the supply of medicines and resources. The excess mortality observed during the COVID-19 pandemic, due to a combination of viral illness and chronic disease states, is bound to increase exponentially from poorly treated NCDs. In this report, we discuss the impact of the war on the public health of Ukraine and potential interventions to provide remote health assistance to the Ukrainian population.

Published
2022

116. Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis

Author

Zeybel, Mujdat, primary, Arif, Muhammad, additional, Li, Xiangyu, additional, Altay, Ozlem, additional, Yang, Hong, additional, Shi, Mengnan, additional, Akyildiz, Murat, additional, Saglam, Burcin, additional, Gonenli, Mehmet Gokhan, additional, Yigit, Buket, additional, Ulukan, Burge, additional, Ural, Dilek, additional, Shoaie, Saeed, additional, Turkez, Hasan, additional, Nielsen, Jens, additional, Zhang, Cheng, additional, Uhlén, Mathias, additional, Borén, Jan, additional, and Mardinoglu, Adil, additional

Published
2022
Full Text
View/download PDF

117. Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment

Author

Wiegman, Albert, Gidding, Samuel S., Watts, Gerald F., Chapman, M. John, Ginsberg, Henry N., Cuchel, Marina, Ose, Leiv, Averna, Maurizio, Boileau, Catherine, Borén, Jan, Bruckert, Eric, Catapano, Alberico L., Defesche, Joep C., Descamps, Olivier S., Hegele, Robert A., Hovingh, G. Kees, Humphries, Steve E., Kovanen, Petri T., Kuivenhoven, Jan Albert, Masana, Luis, Nordestgaard, Børge G., Pajukanta, Päivi, Parhofer, Klaus G., Raal, Frederick J., Ray, Kausik K., Santos, Raul D., Stalenhoef, Anton F.H., Steinhagen- Thiessen, Elisabeth, Stroes, Erik S., Taskinen, Marja-Riitta, Tybjærg-Hansen, Anne, Wiklund, Olov, Averna, Maurizio, Boileau, Catherine, Borén, Jan, Bruckert, Eric, Catapano, Alberico L., Chapman, M. John, Cuchel, Marina, Defesche, Joep C., Descamps, Olivier S., Gidding, Samuel S., Ginsberg, Henry N., Hegele, Robert A., Hovingh, G. Kees, Humphries, Steve E., Kovanen, Petri T., Kuivenhoven, Jan Albert, Masana, Luis, Nordestgaard, Børge G., Ose, Leiv, Pajukanta, Päivi, Parhofer, Klaus G., Raal, Frederick J., Ray, Kausik K, Santos, Raul D., Stalenhoef, Anton F. H., Steinhagen-Thiessen, Elisabeth, Stroes, Erik S., Taskinen, Marja-Riitta, Tybjærg-Hansen, Anne, Watts, Gerald F., Wiegman, Albert, Wiklund, Olov, Gidding, Samuel S., Watts, Gerald F., Chapman, M. John, Ginsberg, Henry N., Cuchel, Marina, Ose, Leiv, Chapman, M. John, and Ginsberg, Henry N.

Published
2015
Full Text
View/download PDF

119. The role of circulating galectin-1 in type 2 diabetes and chronic kidney disease: evidence from cross-sectional, longitudinal and Mendelian randomisation analyses

Author

Drake, Isabel, primary, Fryk, Emanuel, additional, Strindberg, Lena, additional, Lundqvist, Annika, additional, Rosengren, Anders H., additional, Groop, Leif, additional, Ahlqvist, Emma, additional, Borén, Jan, additional, Orho-Melander, Marju, additional, and Jansson, Per-Anders, additional

Published
2021
Full Text
View/download PDF

120. Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

Author

Cuchel, Marina, Bruckert, Eric, Ginsberg, Henry N., Raal, Frederick J., Santos, Raul D., Hegele, Robert A., Kuivenhoven, Jan Albert, Nordestgaard, Børge G., Descamps, Olivier S., Steinhagen-Thiessen, Elisabeth, Tybjærg-Hansen, Anne, Watts, Gerald F., Averna, Maurizio, Boileau, Catherine, Borén, Jan, Catapano, Alberico L., Defesche, Joep C., Hovingh, G. Kees, Humphries, Steve E., Kovanen, Petri T., Masana, Luis, Pajukanta, Päivi, Parhofer, Klaus G., Ray, Kausik K., Stalenhoef, Anton F. H., Stroes, Erik, Taskinen, Marja-Riitta, Wiegman, Albert, Wiklund, Olov, Chapman, M. John, Cuchel, Marina, Bruckert, Eric, Chapman, M. John, Descamps, Olivier S., Ginsberg, Henry N., Hegele, Robert A., Kuivenhoven, Jan Albert, Nordestgaard, Børge G., Raal, Frederick J., Santos, Raul D., Steinhagen-Thiessen, Elisabeth, Tybjærg-Hansen, Anne, Watts, Gerald F., Chapman, M. John, Ginsberg, Henry N., Averna, Maurizio, Boileau, Catherine, Borén, Jan, Catapano, Alberico L., Defesche, Joep C., Hovingh, G. Kees, Humphries, Steve E., Kovanen, Petri T., Masana, Luis, Pajukanta, Päivi, Parhofer, Klaus G., Ray, Kausik K., Stalenhoef, Anton F. H., Stroes, Erik, Taskinen, Marja-Riitta, Wiegman, Albert, and Wiklund, Olov

Published
2014
Full Text
View/download PDF

122. Early rise in brain damage markers and high ICOS expression in CD4+ and CD8+ T cells during checkpoint inhibitor-induced encephalomyelitis

Author

Bjursten, Sara, Pandita, Ankur, Zhao, Zhiyuan, Fröjd, Charlotta, Ny, Lars, Jensen, Christer, Ullerstam, Tobias, Jespersen, Henrik, Borén, Jan, Levin, Malin, Zetterberg, Henrik, Rudin, Anna, and Levin, Max

Subjects
CD4-Positive T-Lymphocytes, Male, autoimmunity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Case Report, CD8-Positive T-Lymphocytes, 2518 1619, Inducible T-Cell Co-Stimulator Protein, melanoma, Humans, Brain Damage, Chronic, immunotherapy, Encephalomyelitis, Immune Checkpoint Inhibitors, RC254-282, Biomarkers, Aged
Abstract

We report a case of rapid eradication of melanoma brain metastases and simultaneous near-fatal encephalomyelitis following double immune checkpoint blockade. Brain damage marker S-100B and C reactive protein increased before symptoms or signs of encephalomyelitis and peaked when the patient fell into a coma. At that point, additional brain damage markers and peripheral T cell phenotype was analyzed. The analyses were repeated four times during the patient’s recovery. Axonal damage marker neurofilament light polypeptide (NFL) and astrocytic damage marker glial fibrillar acidic protein (GFAP) were very high in blood and cerebrospinal fluid and gradually normalized after immunosuppression and intensive care. The costimulatory receptor inducible T cell costimulatory receptor (ICOS) was expressed on a high proportion of CD4+ and CD8+T cells as encephalomyelitis symptoms peaked and then gradually decreased in parallel with clinical improvement. Both single and double immune checkpoint inhibitor-treated melanoma patients with other serious immune-related adverse events (irAE) (n=9) also expressed ICOS on a significantly higher proportion of CD4+ and CD8+T cells compared with controls without irAE (n=12). In conclusion, our results suggest a potential role for ICOS on CD4+ and CD8+T cells in mediating encephalomyelitis and other serious irAE. In addition, brain damage markers in blood could facilitate early diagnosis of encephalitis.

Published
2021

123. Effects of liraglutide on the metabolism of triglyceride‐rich lipoproteins in type 2 diabetes

Author

Taskinen, Marja‐Riitta, Björnson, Elias, Matikainen, Niina, Söderlund, Sanni, Pietiläinen, Kirsi H., Ainola, Mari, Hakkarainen, Antti, Lundbom, Nina, Fuchs, Johannes, Thorsell, Annika, Andersson, Linda, Adiels, Martin, Packard, Chris J., and Borén, Jan

Abstract

Aim: \ud To elucidate the impact of liraglutide on the kinetics of apolipoprotein (apo)B48- and apoB100-containing triglyceride-rich lipoproteins in subjects with type 2 diabetes (T2D) after a single fat-rich meal.\ud \ud Materials and Methods: \ud Subjects with T2D were included in a study to investigate postprandial apoB48 and apoB100 metabolism before and after 16 weeks on l.8 mg/day liraglutide (n = 14) or placebo (n = 4). Stable isotope tracer and compartmental modelling techniques were used to determine the impact of liraglutide on chylomicron and very low-density lipoprotein (VLDL) production and clearance after a single fat-rich meal.\ud \ud Results: \ud Liraglutide reduced apoB48 synthesis in chylomicrons by 60% (p

Published
2021

124. Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet

Author

Yang, Hong, primary, Mayneris-Perxachs, Jordi, additional, Boqué, Noemí, additional, del Bas, Josep M., additional, Arola, Lluís, additional, Yuan, Meng, additional, Türkez, Hasan, additional, Uhlén, Mathias, additional, Borén, Jan, additional, Zhang, Cheng, additional, Mardinoglu, Adil, additional, and Caimari, Antoni, additional

Published
2021
Full Text
View/download PDF

125. Testosterone reduces metabolic brown fat activity in male mice

Author

Lantero Rodriguez, Marta, primary, Schilperoort, Maaike, additional, Johansson, Inger, additional, Svedlund Eriksson, Elin, additional, Palsdottir, Vilborg, additional, Kroon, Jan, additional, Henricsson, Marcus, additional, Kooijman, Sander, additional, Ericson, Mia, additional, Borén, Jan, additional, Ohlsson, Claes, additional, Jansson, John-Olov, additional, Levin, Malin C, additional, Rensen, Patrick C N, additional, and Tivesten, Åsa, additional

Published
2021
Full Text
View/download PDF

126. Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients

Author

Zeybel, Mujdat, primary, Altay, Ozlem, additional, Arif, Muhammad, additional, Li, Xiangyu, additional, Yang, Hong, additional, Fredolini, Claudia, additional, Akyildiz, Murat, additional, Saglam, Burcin, additional, Gonenli, Mehmet Gokhan, additional, Ural, Dilek, additional, Kim, Woonghee, additional, Schwenk, Jochen M, additional, Zhang, Cheng, additional, Shoaie, Saeed, additional, Nielsen, Jens, additional, Uhlén, Mathias, additional, Borén, Jan, additional, and Mardinoglu, Adil, additional

Published
2021
Full Text
View/download PDF

127. Effects of PNPLA3 I148M on hepatic lipid and very‐low‐density lipoprotein metabolism in humans

Author

Borén, Jan, primary, Adiels, Martin, additional, Björnson, Elias, additional, Matikainen, Niina, additional, Söderlund, Sanni, additional, Rämö, Joel, additional, Henricsson, Marcus, additional, Ripatti, Pietari, additional, Ripatti, Samuli, additional, Palotie, Aarno, additional, Mancina, Rosellina M., additional, Ainola, Mari, additional, Hakkarainen, Antti, additional, Romeo, Stefano, additional, Packard, Chris J., additional, and Taskinen, Marja‐Riitta, additional

Published
2021
Full Text
View/download PDF

128. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus statement from the European Atherosclerosis Society

Author

Ginsberg, Henry N, primary, Packard, Chris J, additional, Chapman, M John, additional, Borén, Jan, additional, Aguilar-Salinas, Carlos A, additional, Averna, Maurizio, additional, Ference, Brian A, additional, Gaudet, Daniel, additional, Hegele, Robert A, additional, Kersten, Sander, additional, Lewis, Gary F, additional, Lichtenstein, Alice H, additional, Moulin, Philippe, additional, Nordestgaard, Børge G, additional, Remaley, Alan T, additional, Staels, Bart, additional, Stroes, Erik S G, additional, Taskinen, Marja-Riitta, additional, Tokgözoğlu, Lale S, additional, Tybjaerg-Hansen, Anne, additional, Stock, Jane K, additional, and Catapano, Alberico L, additional

Published
2021
Full Text
View/download PDF

129. Sphingosine 1-Phosphate Mediates Adiponectin Receptor Signaling Essential For Lipid Homeostasis And Embryogenesis

Author

Ruiz, Mario, primary, Devkota, Ranjan, additional, Panagaki, Dimitra, additional, Bergh, Per-Olof, additional, Kaper, Delaney, additional, Henricsson, Marcus, additional, Nik, Ali, additional, Petkevicius, Kasparas, additional, Höög, Johanna L., additional, Bohlooly-Y, Mohammad, additional, Carlsson, Peter, additional, Borén, Jan, additional, and Pilon, Marc, additional

Published
2021
Full Text
View/download PDF

131. Combined Metabolic Activators Improve Cognitive Functions without Altering Motor Scores in Parkinson’s Disease

Author

Yulug, Burak, primary, Altay, Ozlem, additional, Li, Xiangyu, additional, Hanoglu, Lutfu, additional, Cankaya, Seyda, additional, Lam, Simon, additional, Yang, Hong, additional, Coskun, Ebru, additional, İdil, Ezgi, additional, Nogaylar, Rahim, additional, Hacımuftuoglu, Ahmet, additional, Arif, Muhammad, additional, Shoaie, Saeed, additional, Zhang, Cheng, additional, Nielsen, Jens, additional, Turkez, Hasan, additional, Borén, Jan, additional, Uhlén, Mathias, additional, and Mardinoglu, Adil, additional

Published
2021
Full Text
View/download PDF

132. Overeating Saturated Fat Promotes Fatty Liver and Ceramides Compared With Polyunsaturated Fat: A Randomized Trial

Author

Rosqvist, Fredrik, Kullberg, Joel, Ståhlman, Marcus, Cedernaes, Jonathan, Heurling, Kerstin, Johansson, Hans-Erik, Iggman, David, Wilking, Helena, Larsson, Anders, Eriksson, Olof, Johansson, Lars, Straniero, Sara, Rudling, Mats, Antoni, Gunnar, Lubberink, Mark, Orho-Melander, Marju, Borén, Jan, Ahlström, Håkan, and Risérus, Ulf

Subjects
Adult, Male, Lipids and Cardiovascular, food and beverages, Hyperphagia, Overweight, Ceramides, Prognosis, Weight Gain, Dietary Fats, Lipids, Fatty Liver, Double-Blind Method, Fatty Acids, Unsaturated, Humans, Female, Obesity, Clinical Research Articles, Follow-Up Studies
Abstract

Context Saturated fatty acid (SFA) vs polyunsaturated fatty acid (PUFA) may promote nonalcoholic fatty liver disease by yet unclear mechanisms. Objective To investigate if overeating SFA- and PUFA-enriched diets lead to differential liver fat accumulation in overweight and obese humans. Design Double-blind randomized trial (LIPOGAIN-2). Overfeeding SFA vs PUFA for 8 weeks, followed by 4 weeks of caloric restriction. Setting General community. Participants Men and women who are overweight or have obesity (n = 61). Intervention Muffins, high in either palm (SFA) or sunflower oil (PUFA), were added to the habitual diet. Main Outcome Measures Lean tissue mass (not reported here). Secondary and exploratory outcomes included liver and ectopic fat depots. Results By design, body weight gain was similar in SFA (2.31 ± 1.38 kg) and PUFA (2.01 ± 1.90 kg) groups, P = 0.50. SFA markedly induced liver fat content (50% relative increase) along with liver enzymes and atherogenic serum lipids. In contrast, despite similar weight gain, PUFA did not increase liver fat or liver enzymes or cause any adverse effects on blood lipids. SFA had no differential effect on the accumulation of visceral fat, pancreas fat, or total body fat compared with PUFA. SFA consistently increased, whereas PUFA reduced circulating ceramides, changes that were moderately associated with liver fat changes and proposed markers of hepatic lipogenesis. The adverse metabolic effects of SFA were reversed by calorie restriction. Conclusions SFA markedly induces liver fat and serum ceramides, whereas dietary PUFA prevents liver fat accumulation and reduces ceramides and hyperlipidemia during excess energy intake and weight gain in overweight individuals., We show the importance of dietary fat type on liver fat accumulation and ceramides during overfeeding-induced weight gain in 61 overweight men and women.

Published
2019

136. Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

Author

Dongiovanni, Paola, Petta, Salvatore, Maglio, Cristina, Fracanzani, Anna Ludovica, Pipitone, Rosaria, Mozzi, Enrico, Motta, Benedetta Maria, Kaminska, Dorota, Rametta, Raffaela, Grimaudo, Stefania, Pelusi, Serena, Montalcini, Tiziana, Alisi, Anna, Maggioni, Marco, Kärjä, Vesa, Borén, Jan, Käkelä, Pirjo, Di Marco, Vito, Xing, Chao, Nobili, Valerio, Dallapiccola, Bruno, Craxi, Antonio, Pihlajamäki, Jussi, Fargion, Silvia, Sjöström, Lars, Carlsson, Lena M., Romeo, Stefano, and Valenti, Luca

Published
2015
Full Text
View/download PDF

139. Combined Metabolic Activators Improves Cognitive Functions in Alzheimer’s Disease

Author

Yulug, Burak, primary, Altay, Ozlem, additional, Li, Xiangyu, additional, Hanoglu, Lutfu, additional, Cankaya, Seyda, additional, Lam, Simon, additional, Yang, Hong, additional, Coskun, Ebru, additional, İdil, Ezgi, additional, Nogaylar, Rahim, additional, Bayram, Cemil, additional, Bolat, Ismail, additional, Öner, Sena, additional, Tozlu, Özlem Özdemir, additional, Arslan, Mehmet Enes, additional, Hacımuftuoglu, Ahmet, additional, Yıldırım, Serkan, additional, Arif, Muhammad, additional, Shoaie, Saeed, additional, Zhang, Cheng, additional, Nielsen, Jens, additional, Turkez, Hasan, additional, Borén, Jan, additional, Uhlén, Mathias, additional, and Mardinoglu, Adil, additional

Published
2021
Full Text
View/download PDF

140. Combined Metabolic Activators Accelerates Recovery in Mild‐to‐Moderate COVID‐19

Author

Altay, Ozlem, primary, Arif, Muhammad, additional, Li, Xiangyu, additional, Yang, Hong, additional, Aydın, Mehtap, additional, Alkurt, Gizem, additional, Kim, Woonghee, additional, Akyol, Dogukan, additional, Zhang, Cheng, additional, Dinler‐Doganay, Gizem, additional, Turkez, Hasan, additional, Shoaie, Saeed, additional, Nielsen, Jens, additional, Borén, Jan, additional, Olmuscelik, Oktay, additional, Doganay, Levent, additional, Uhlén, Mathias, additional, and Mardinoglu, Adil, additional

Published
2021
Full Text
View/download PDF

141. Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking

Author

Andersson, Linda, primary, Cinato, Mathieu, additional, Mardani, Ismena, additional, Miljanovic, Azra, additional, Arif, Muhammad, additional, Koh, Ara, additional, Lindbom, Malin, additional, Laudette, Marion, additional, Bollano, Entela, additional, Omerovic, Elmir, additional, Klevstig, Martina, additional, Henricsson, Marcus, additional, Fogelstrand, Per, additional, Swärd, Karl, additional, Ekstrand, Matias, additional, Levin, Max, additional, Wikström, Johannes, additional, Doran, Stephen, additional, Hyötyläinen, Tuulia, additional, Sinisalu, Lisanna, additional, Orešič, Matej, additional, Tivesten, Åsa, additional, Adiels, Martin, additional, Bergo, Martin O, additional, Proia, Richard, additional, Mardinoglu, Adil, additional, Jeppsson, Anders, additional, Borén, Jan, additional, and Levin, Malin C, additional

Published
2021
Full Text
View/download PDF

142. Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma

Author

Besse, Lenka, primary, Besse, Andrej, additional, Stolze, Sara C., additional, Sobh, Amin, additional, Zaal, Esther A., additional, van der Ham, Alwin J., additional, Ruiz, Mario, additional, Phuyal, Santosh, additional, Büchler, Lorina, additional, Sathianathan, Marc, additional, Florea, Bogdan I., additional, Borén, Jan, additional, Ståhlman, Marcus, additional, Huber, Julia, additional, Bolomsky, Arnold, additional, Ludwig, Heinz, additional, Hannich, J. Thomas, additional, Loguinov, Alex, additional, Everts, Bart, additional, Berkers, Celia R., additional, Pilon, Marc, additional, Farhan, Hesso, additional, Vulpe, Christopher D., additional, Overkleeft, Herman S., additional, and Driessen, Christoph, additional

Published
2021
Full Text
View/download PDF

144. The year 2020 in Atherosclerosis

Author

Binder, Christoph J., primary, Borén, Jan, additional, Catapano, Alberico, additional, Kronenberg, Florian, additional, Mallat, Ziad, additional, Negrini, Simona, additional, Öörni, Katariina, additional, Raggi, Paolo, additional, and von Eckardstein, Arnold, additional

Published
2021
Full Text
View/download PDF

145. Multi-omics analysis reveals the impact of microbiota on host metabolism in hepatic steatosis

Author

Zeybel, Mujdat, primary, Arif, Muhammad, additional, Li, Xiangyu, additional, Altay, Ozlem, additional, Shi, Mengnan, additional, Akyildiz, Murat, additional, Saglam, Burcin, additional, Gonenli, Mehmet Gokhan, additional, Yigit, Buket, additional, Ulukan, Burge, additional, Ural, Dilek, additional, Shoaie, Saeed, additional, Turkez, Hasan, additional, Nielsen, Jens, additional, Zhang, Cheng, additional, Uhlén, Mathias, additional, Borén, Jan, additional, and Mardinoglu, Adil, additional

Published
2021
Full Text
View/download PDF

146. Combined Metabolic Activators Reduces Liver Fat in Nonalcoholic Fatty Liver Disease Patients

Author

Zeybel, Mujdat, primary, Altay, Ozlem, additional, Arif, Muhammad, additional, Li, Xiangyu, additional, Yang, Hong, additional, Fredolini, Claudia, additional, Akyildiz, Murat, additional, Saglam, Burcin, additional, Gonenli, Mehmet Gokhan, additional, Ural, Dilek, additional, Kim, Woonghee, additional, Schwenk, Jochen M., additional, Zhang, Cheng, additional, Shoaie, Saeed, additional, Nielsen, Jens, additional, Uhlén, Mathias, additional, Borén, Jan, additional, and Mardinoglu, Adil, additional

Published
2021
Full Text
View/download PDF

148. Supplemental Material for Devkota et al., 2021

Author

Devkota, Ranjan, Kaper, Delaney, Bodhicharla, Rakesh, Henricsson, Marcus, Borén, Jan, and Pilon, Marc

Subjects
Physiology, FOS: Biological sciences, Genetics, 60103 Cell Development, Proliferation and Death, Cell Biology, Molecular Biology, 60104 Cell Metabolism
Abstract

This file contains supplemental figures to the article entitled "A Genetic Titration of Membrane Composition in C. elegans Reveals its Importance for Multiple Cellular and Physiological Traits".

Published
2021
Full Text
View/download PDF

149. Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking

Author

Andersson, Linda, Cinato, Mathieu, Mardani, Ismena, Miljanovic, Azra, Arif, Muhammad, Koh, Ara, Lindbom, Malin, Laudette, Marion, Bollano, Entela, Omerovic, Elmir, Klevstig, Martina, Henricsson, Marcus, Fogelstrand, Per, Swärd, Karl, Ekstrand, Matias, Levin, Max, Wikström, Johannes, Doran, Stephen, Hyötyläinen, Tuulia, Sinisalu, Lisanna, Oresic, Matej, Tivesten, Åsa, Adiels, Martin, Bergo, Martin O., Proia, Richard, Mardinoglu, Adil, Jeppsson, Anders, Borén, Jan, Levin, Malin C., Andersson, Linda, Cinato, Mathieu, Mardani, Ismena, Miljanovic, Azra, Arif, Muhammad, Koh, Ara, Lindbom, Malin, Laudette, Marion, Bollano, Entela, Omerovic, Elmir, Klevstig, Martina, Henricsson, Marcus, Fogelstrand, Per, Swärd, Karl, Ekstrand, Matias, Levin, Max, Wikström, Johannes, Doran, Stephen, Hyötyläinen, Tuulia, Sinisalu, Lisanna, Oresic, Matej, Tivesten, Åsa, Adiels, Martin, Bergo, Martin O., Proia, Richard, Mardinoglu, Adil, Jeppsson, Anders, Borén, Jan, and Levin, Malin C.

Abstract

AIMS: Cardiac injury and remodelling are associated with the rearrangement of cardiac lipids. Glycosphingolipids are membrane lipids that are important for cellular structure and function, and cardiac dysfunction is a characteristic of rare monogenic diseases with defects in glycosphingolipid synthesis and turnover. However, it is not known how cardiac glycosphingolipids regulate cellular processes in the heart. The aim of this study is to determine the role of cardiac glycosphingolipids in heart function. METHODS AND RESULTS: Using human myocardial biopsies, we showed that the glycosphingolipids glucosylceramide and lactosylceramide are present at very low levels in non-ischaemic human heart with normal function and are elevated during remodelling. Similar results were observed in mouse models of cardiac remodelling. We also generated mice with cardiomyocyte-specific deficiency in Ugcg, the gene encoding glucosylceramide synthase (hUgcg-/- mice). In 9- to 10-week-old hUgcg-/- mice, contractile capacity in response to dobutamine stress was reduced. Older hUgcg-/- mice developed severe heart failure and left ventricular dilatation even under baseline conditions and died prematurely. Using RNA-seq and cell culture models, we showed defective endolysosomal retrograde trafficking and autophagy in Ugcg-deficient cardiomyocytes. We also showed that responsiveness to β-adrenergic stimulation was reduced in cardiomyocytes from hUgcg-/- mice and that Ugcg knockdown suppressed the internalization and trafficking of β1-adrenergic receptors. CONCLUSIONS: Our findings suggest that cardiac glycosphingolipids are required to maintain β-adrenergic signalling and contractile capacity in cardiomyocytes and to preserve normal heart function.

Published
2021
Full Text
View/download PDF

150. Triglyceride-rich lipoproteins and their remnants:Metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies - a consensus statement from the European Atherosclerosis Society

Author

Ginsberg, Henry N, Packard, Chris J, Chapman, M John, Borén, Jan, Aguilar-Salinas, Carlos A, Averna, Maurizio, Ference, Brian A., Gaudet, Daniel, Hegele, Robert A, Kersten, Sander, Lewis, Gary F., Lichtenstein, Alice H., Moulin, Philippe, Nordestgaard, Børge G., Remaley, Alan T, Staels, Bart, Stroes, Erik S. G., Taskinen, Marja-Riitta, Tokgözoğlu, Lale S, Tybjaerg-Hansen, Anne, Stock, Jane K., Catapano, Alberico L, Ginsberg, Henry N, Packard, Chris J, Chapman, M John, Borén, Jan, Aguilar-Salinas, Carlos A, Averna, Maurizio, Ference, Brian A., Gaudet, Daniel, Hegele, Robert A, Kersten, Sander, Lewis, Gary F., Lichtenstein, Alice H., Moulin, Philippe, Nordestgaard, Børge G., Remaley, Alan T, Staels, Bart, Stroes, Erik S. G., Taskinen, Marja-Riitta, Tokgözoğlu, Lale S, Tybjaerg-Hansen, Anne, Stock, Jane K., and Catapano, Alberico L

Abstract

Recent advances in human genetics, together with a large body of epidemiologic, preclinical, and clinical trial results, provide strong support for a causal association between triglycerides (TG), TG-rich lipoproteins (TRL), and TRL remnants, and increased risk of myocardial infarction, ischaemic stroke, and aortic valve stenosis. These data also indicate that TRL and their remnants may contribute significantly to residual cardiovascular risk in patients on optimized low-density lipoprotein (LDL)-lowering therapy. This statement critically appraises current understanding of the structure, function, and metabolism of TRL, and their pathophysiological role in atherosclerotic cardiovascular disease (ASCVD). Key points are (i) a working definition of normo- and hypertriglyceridaemic states and their relation to risk of ASCVD, (ii) a conceptual framework for the generation of remnants due to dysregulation of TRL production, lipolysis, and remodelling, as well as clearance of remnant lipoproteins from the circulation, (iii) the pleiotropic proatherogenic actions of TRL and remnants at the arterial wall, (iv) challenges in defining, quantitating, and assessing the atherogenic properties of remnant particles, and (v) exploration of the relative atherogenicity of TRL and remnants compared to LDL. Assessment of these issues provides a foundation for evaluating approaches to effectively reduce levels of TRL and remnants by targeting either production, lipolysis, or hepatic clearance, or a combination of these mechanisms. This consensus statement updates current understanding in an integrated manner, thereby providing a platform for new therapeutic paradigms targeting TRL and their remnants, with the aim of reducing the risk of ASCVD.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results