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Purpose To evaluate the safety and efficacy of dexamethasone phosphate ophthalmic solution (EGP-437) delivered by a transscleral iontophoresis delivery system (EyeGate II) compared to that of topical prednisolone acetate 1% (PA 1%) in subjects with noninfectious anterior uveitis. Design Prospective, randomized, double-masked, parallel group, noninferiority clinical trial. Methods A total of 193 subjects with active noninfectious anterior uveitis (anterior chamber [AC] cell count ≥11 cells) were randomized to EGP-437 delivered by iontophoresis (days 0 and 7) or self-administered PA 1% daily (tapered schedule, days 0-28). Masking was maintained with placebo iontophoresis or eye drops. The primary efficacy endpoint was the proportion of subjects with an AC cell count of zero on day 14. Noninferiority of EGP-437 was defined if the lower limit of the confidence interval (CI) for the difference (EGP-437 minus PA 1%) was less than −10%. Results At day 14, 32 of 96 EGP-437 subjects (33.3%) and 32 of 97 PA 1% subjects (33.0%) had an AC cell count of zero (difference, 0.34; 95% CI, −12.94 to 13.63; P = 0.064). Efficacy trended better with EGP-437 among patients with more severe baseline uveitis (AC cell count >25). Safety and tolerability were good with both treatments. EGP-437 subjects experienced fewer IOP elevations ≥6 mm Hg versus PA 1% subjects (13 vs 24 incidents, respectively, through day 28). Conclusions Despite clinically similar response rates, statistical noninferiority of EGP-437 versus a tapered regimen of PA 1% was not achieved. Numerical trends suggesting fewer IOP elevations with EGP-437, similar efficacy overall, and possibly better efficacy in more severe disease warrant further study.

The aim of this chapter is to present an automated instrument collecting the enormous amount of information available online allowing urban planners, public administrations, tourism services suppliers, and researchers to easily understand the spatial and temporal distribution of tourist behaviors towards tourist attractions in a specific area. Geo-located photos provided by Flickr are used to identify points of interest (POIs). The developed application has been tested with data automatically retrieved and collected in L'Aquila province (Italy) during the years 2005-2018. Given the richness of information, these data are able to show how POIs changed over time and how tourists reacted to the 2009 earthquake. Results demonstrate the importance of using analytics and big data in tourism research. Moreover, by using the province of L'Aquila as pilot study, it emerges that tourist behaviors change over time and space, varying among different typologies of tourists: residents, domestic, and international visitors.

Since 1999, an unusual Phytophthora species has repeatedly been found associated with stem lesions and root and collar rot on young olive trees in Southern Italy. In all cases, this species was obtained from recently established commercial plantations or from nursery plants. Morphologically, the Phytophthora isolates were characterized by the abundant production of caducous non-papillate conidia-like sporangia (pseudoconidia) and caducous papillate sporangia with a short pedicel, resembling P. palmivora var. heterocystica. Additional isolates with similar features were obtained from nursery plants of Ziziphus spina-christi in Iran, Juniperus oxycedrus and Capparis spinosa in Italy, and mature trees in commercial farms of Durio zibethinus in Vietnam. In this study, morphology, breeding system and growth characteristics of these Phytophthora isolates with peculiar features were examined, and combined mitochondrial and nuclear multigene phylogenetic analyses were performed. The proportion between pseudoconidia and sporangia varied amongst isolates and depended on the availability of free water. Oogonia with amphigynous antheridia and aplerotic oospores were produced in dual cultures with an A2 mating type strain of P. palmivora, indicating all isolates were A1 mating type. Phylogenetically, these isolates grouped in a distinct well-supported clade sister to P. palmivora, thus, they constitute a separate taxon. The new species, described here as Phytophthora heterospora sp. nov., proved to be highly pathogenic to both olive and durian plants in stem inoculation tests.

Purpose The purpose of this paper is to assess the “motivation-satisfaction-loyalty” framework. Through a structural equation model (SEM), it is possible to disentangle attitudinal and behavioral loyalty as a multifaceted latent variable. Design/methodology/approach The empirical analysis is based on data collected in wineries located in two important wine destinations: Trentino and South Tyrol (Italy). Notably, the motivation–satisfaction relationship is confirmed, and the SEM has also assessed the importance of winery services in affecting loyalty, expressed in terms of “visit other cellars,” “repeat a wine vacation” and “recommend wine routes.” Findings Destination managers should consider the wine-related “relaxation” as the main push motivation, while the interactions experience are important pull motivations to drive wine tourists’ satisfaction. Nevertheless, the findings reveal that more proactive policies are needed to enhance local wines loyalty. Originality/value The novelty of this study is to explore loyalty. In this respect, a multifaceted latent variable is expressed as follows: “buy local wines,” “visit other cellars,” “repeat a wine vacation” as behavioral attitudinal stated loyalty and “recommend wine routes” as attitudinal stated loyalty.

INTRODUCTION Although contemporary health care involves complex interactions among clinicians of varying professions, opportunities to learn together are relatively few. The authors assessed participants' views about the educational value of learning with colleagues of mixed health care professions in communication and relational skills training focused on challenging conversations. METHODS Between 2010 and 2013, 783 participants enrolled in 46 workshops hosted by the Institute for Professionalism and Ethical Practice at Boston Children's Hospital, Boston, USA. Participants received pre-, post-, and 3-month follow-up questionnaires with quantitative and qualitative questions about their experiences learning with clinicians of varying professions ("interprofessional learning"). Descriptive statistics and chi-square tests were used to compare participant groups. Responses to open-ended questions were coded according to standard principles of content analysis. RESULTS Seven hundred twenty-two (92%) participants completed surveys. Previous interprofessional learning was reported by 60% of respondents, but generally comprised

The small Plio-Quaternary volcanic centre of Cabezo Negro de Tallante in SE Spain includes a thick deposit of polymictic pyroclastic tuff-breccia, whose fragments are agglutinated by a carbonate-rich component. This feature is also observed in other monogenetic volcanic centres cropping out in the Tallante-Cartagena volcanic district. The carbonate fraction has been recently interpreted in literature as representing a mantle component, therefore pointing to the existence of a diffuse carbonatitic activity in the area. Based on detailed sedimentological (presence of pisoids and root remnants), petrographic (presence of plagioclase and absence of euhedral silicate minerals in the calcite plagues), mineral chemistry (Ba-Sr-poor calcite composition), whole-rock chemistry (overall low incompatible element content in the pure carbonate fraction and a monotonous trace element negative correlation with CaO) as well as isotopic constraints (perfect correlations between Sr-Nd-Pb isotopic ratios with CaO in the basaltic and carbonate fraction, as well as heavy δ18O and light δ13C isotopic composition of the carbonate fraction), we propose a secondary origin for the carbonate component, excluding any contribution of mantle carbonatite melts. The presence of carbonates infiltrating the abundant mantle and crustal xenolith fragments found in the pyroclastic breccia is not related to the presence of carbonatitic melts at mantle to lower crustal depths, but to in-situ fragmentation of the Strombolian tuff-breccia deposit, followed by secondary carbonate infiltration. The pyroclastic breccia was indeed affected by an alternation of carbonate precipitation and dissolution in a vadose zone, where the activity of bacteria, fungi, roots and meteoric water led to the formation of a calcrete (caliche)-type deposits. Basaltic rocks (hawaiites and basanites) occur in the area as scoria and lava fragments in the pyroclastic breccia as well as small lava flows. They have been modelled with a low-degree partial melting of an amphibole-bearing peridotitic mantle close to the lithosphere-asthenosphere boundary. The origin of the mildly alkaline sodic basaltic activity in SE Spain post-dates the abundant and long-lasting subduction-related volcanic phase in the Betic Chain. Its origin is explained without requiring the presence of any thermal anomaly, but simply as consequence of the difference of lithospheric depths and edge-driven-type small-scale convection.

The late Miocene is a crucial interval for global climate evolution as well as for the regional geodynamic evolution of the Central Mediterranean area. It spans the transition from the warm Mid Miocene Climatic Optimum, associated with the major Monterey Carbon Isotope Excursion, to the cooler Pliocene, characterized by a bipolar glaciation. Within this climatic transition, during the early Tortonian, a positive carbon isotope excursion related to a global carbon cycle perturbation is recorded, named Carbon Maximum 7 (CM7). In this study, two upper Serravallian-lower Tortonian carbonate ramps of the Central Mediterranean have been analysed: the Latium-Abruzzi and the Apula ramps (Central Apennines, Central Italy). Carbon isotope ratios have been coupled with facies and microfacies analyses with the aims: (1) to identify the CM7 in the Central Mediterranean carbonate ramp successions; (2) to evaluate potential carbonate factory changes or demises related to the CM7; and (3) to discriminate the role of global vs regional factors in affecting the Mediterranean carbonate ramps. The two studied ramps show different evolutions due to regional geodynamics causes. The Latium-Abruzzi ramp drowns in the Tortonian, while the Apula shows a regressive trend, with upper Tortonian middle ramp facies overlying the lower Tortonian outer ramp. Despite the complex geodynamic setting, a positive carbon isotope shift has been identified in both ramps and correlated with the CM7. This positive carbon isotope shift may be linked to the strengthening of the global ocean circulation during the late Miocene cooling. This strengthening of the circulation enhanced the coastal upwelling, bringing nutrient-rich waters to the surface and triggering an enhanced primary productivity consistent with the CM7.

Supplemental Material, sj-docx-1-teu-10.1177_1354816620987676 for Together or not? Spill-over effects of cultural goods displacement by Maria Giovanna Brandano and Marta Meleddu in Tourism Economics

Despite data coming from fully developed oil fields are fundamental to validate reservoir models, they are rarely publishable because of confidentiality. In this work, we benefit from an exceptionally dense public dataset represented by 43 wells logs drilled in a carbonate-heavy oil-rich reservoir of the Majella Mountain (Central Italy) over a grid of 200 m × 200 m, with depths in the range of 90–200 m. We tested different modelling solutions, to assess the best modelling approach that fits the available data on hydrocarbon distribution. Both deterministic (using Kriging) and stochastic simulations (using Sequential Gaussian Simulation- SGS) were tested. The role of the variogram resulted as a fundamental parameter for both simulation methods. Wells-derived variogram agrees with the size and orientation of carbonate dunes that drive the hydrocarbon distribution highlighting the importance of an accurate depositional model. Kriging was faster in terms of computation time and better in maintaining the lateral continuity of the layers, however, it excessively smoothed the results. SGS gave a better distribution of computed values but the lateral continuity was not preserved. By adding a main vertical trend derived from the upscaled logs to the SGS, results become more accurate. We then applied the best model to estimate the total volume of hydrocarbon in place in an already exploited area starting from just one well. The computed reserves show a good fit with historical production data demonstrating the reliability of the model.

This chapter provides an overview of tourism taxation and explores the extent to which a tourism tax on overnight stays has an impact on domestic and international tourism demand. The analysis employs a policy evaluation technique, the synthetic control method (SCM) developed by (Abadie and Gardeazabal, American Economic Review 93:112–132, 2003), which has rarely been employed within the tourism sector. As a case study, three well-known Italian cities are considered, including Rome, Florence, and Padua. The effects exerted by the policy intervention on tourism flows are evaluated on a panel of cities considering the time span from 2008 up to 2014. In line with other studies, overall, the SCM and the placebo analyses show that the public intervention on tourism demand, evaluated with three different indicators of tourist overnight stays, arrivals, and average length of stay, has not had a specific effect.

Understanding the factors controlling fracture frequency distribution can greatly improve the assessment of fluid circulation in fault damage zones, with evident implications for fault mechanics, hydrogeology and hydrocarbon exploration. This is particularly important for relay zones that are usually characterized by strong damage and structural complexity. We investigated the fracture frequency within an outcrop adjacent to the front fault segment of a relay ramp, hosted within peritidal carbonates that forms part of the Tre Monti fault (Central Italy). We analysed the distribution of fracture frequency in the outcrop through (1) scanlines measured in the field, (2) oriented rock samples, and (3) scan-areas performed on a virtual outcrop model. Fracture frequency increases with distance from the front segment of the relay ramp. Moreover, supratidal and intertidal carbonate facies exhibit higher fracture frequency than subtidal limestones. This trend of increased fracture frequency has two main explanations. (1) The number of subsidiary faults and their associated damage zones increases moving away from the front segment. (2) The supratidal and intertidal carbonate facies content increases toward the centre of the relay ramp. Our results indicate that the fracture frequency pattern is very complex in relay ramps hosted in shallow-water limestones and that its prediction necessitates a good control on structures and sedimentary facies distribution.

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Fractures constitute the main pathway for fluids in fault damage zones hosted in low-porosity rocks. Understanding the factors controlling fracture distribution is hence fundamental to better assess fluids circulation in fault damage zones, with evident implications for fault mechanics, hydrogeology and hydrocarbon exploration. Being usually characterized by a strong damage and structural complexity, this is of particularly importance for relay zones.We integrated classical and modern structural geology techniques to investigate the factors controlling fracture distribution within a portion of a relay ramp damage zone pertaining to the Tre Monti fault (Central Italy). The damage zone is hosted within peritidal carbonates and located at the footwall of the relay ramp front segment. We analysed the distribution of the fracture density in the outcrop through (1) scanlines measured in the field, (2) oriented rock samples, and (3) scan-areas performed on a virtual outcrop model obtained by aerial structure-from-motion.Our results highlight structural and lithological control on fracture distribution. Scanlines and virtual scan-areas show that fracture density increases with the distance from the front segment of the relay ramp. Moreover, all the methods highlight that supratidal and intertidal carbonate facies exhibit higher fracture density than subtidal limestones.This apparently anomalous trend of fracture density, that increases moving away from a main fault segment, has two main explanations. (1) The damage is associated with the relay ramp development: approaching the centre of the relay ramp (i.e., moving away from the front segment) an increase in the number of subsidiary faults with their associated damage zones promotes high fracture densities. (2) The increase in fracture density can be attributed to the increasing content in supratidal and intertidal carbonate facies that are more abundant in the centre of the relay ramp.Our results provide important suggestions for factors controlling fracture distribution and fluid flow within relay ramps hosted by shallow water limestones. We show that the trend of fracture distribution with respect to a main fault is not easily predictable in presence of a relay ramp, because it can be modulated by the subsidiary faults formation and slip during the relay ramp development. Moreover, carbonate facies play a non-negligible role in fracture distribution within fault zones hosted in shallow-water carbonates.

During the Miocene, the upwelling is assumed to be important in the formation of many Mediterranean phosphate deposits in carbonate platform successions. There are different types of upwelling mechanisms such as equatorial upwellings, ice-edge upwellings and coastal upwellings. The carbonate platforms are mainly affected by wind-driven coastal upwelling systems. During upwelling season, the seawater in coastal areas is strongly density stratified and the permanent pycnocline rises inshore forming an inclined frontal layer. The liaison between upwellings and internal waves is widely documented in the literature. Internal waves result from perturbations of the hydrostatic equilibrium, where balance is sustained between the force of gravity and buoyant restoring force. Many perturbations of the pycnocline can propagate as an internal wave. In a coastal upwelling, a key role for wave propagation is played by permanent pycnocline. The run-up swash currents develop during the break of internal waves and produce erosional processes. In particular, the backwash return flow may induce the erosion of seafloor sediments and transport these sediments downslope as bedload. Erosion of phosphate-rich intervals has been extensively documented. The deposition of gravity-flow sediments is followed by intervals of non-deposition, incipient lithification, phosphogenesis and erosion. In this work, we evaluate the role of internal waves in the formation of the resedimented phosphate-rich intervals characterising the basal portion of the hemipelagic Orbulina marls. These marls are deposited on the low-angle Latium-Abruzzi carbonate ramp and represent deposition in a foreland basin during the initial stages of evolution of the Central Apennine Belt during the early Tortonian age.

This two-days field trip is focused on the Bolognano Formation, the homoclinal carbonate ramp developed on the Majella Mountain (Central Apennines) from the late Rupelian to the Messinian. The northern sectors of the Majella Mountain show excellent and continuous exposures of this carbonate ramp. In the late Oligoceneearly Miocene, the paleoceanography of the Mediterranean was controlled by different seaways, one of the largest being the proto-Adriatic basin, bounded by the Apulian carbonate platform and by the Dinaride coast. In this context, a strong northward current led to the development of submarine dunes during the Chattian and the Burdigalian. In this fieldtrip, we discuss the relationships among sedimentary structures and depositional processes, stratigraphic architecture and syn/ post-depositional tectonics. Furthermore, the lower Miocene cross-bedded calcarenites of the Bolognano Fm identify an important reservoir rock. In the last two stops, the bitumen shows are analysed and the possible controlling factors of migration and trapping are discussed. The comparison between bitumen-filled fractured and unfractured rocks allows detecting the controlling factors on the migration of the hydrocarbons and its relationship with tectonics. The high primary porosity and the lateral continuity of the calcarenites are identified as the main controlling factor on the hydrocarbon migration.

The Eocene-Oligocene transition represents the latest greenhouse-icehouse shift faced by Earth, a major global climate change associated with carbon cycle perturbation. In this paper, we investigate the Massignano strati- graphic section (northern Apennines, Italy), GSSP of the Eocene-Oligocene boundary, by X-ray diffraction analy- sis of clay minerals and carbon and oxygen stable isotopes to explore the link among climate, paleoweathering and runoff, and carbon cycle in the Neotethys across this major climatic transition. We examine the interplay be- tween global climate forcing and orogen evolution controlling the Massignano hemipelagic sedimentation. The late Eocene clay mineral assemblages indicate that the Neotethys was sensitive to global eustatic changes as well as changes in composition and rates of weathered sediments accumulating into the basin. The carbon iso- tope record matches with the global signal, showing productivity pulses linked to cooling phases and sea-level drops before 34.8 Ma. Subsequently, a constant negative trend is recorded, which is consistent with the global carbon isotope curve, and attests for a decrease of primary productivity linked to decreasing atmospheric CO2. This negative trend ends at the Eocene-Oligocene boundary, when the onset of the global carbon isotope positive excursion is recorded also within the Massignano hemipelagic succession. On the contrary, the clay mineral as- semblage is quite constant across the Eocene-Oligocene boundary reflecting the complex interplay among fluvial discharge, sea level changes and orogen dynamics which clouded the global climate shift. In this context, the en- hanced fluvial discharge likely contributed to sustain high trophic conditions in the Adriatic waters and, in turn, the Oligocene positive carbon isotope shift. These results highlight how clay minerals proved to be a useful proxy to identify the interplay between global and regional controlling factors on hemipelagic sedimentation and, their integration with the carbon isotope record, provides insights into carbon cycle dynamics.

This work illustrates a combined modelling approach using digital photogrammetry and geological modelling to create a high detailed 3D facies model of the inner environment of the Monte Carrubba carbonate ramp outcropping in the South Sicily. The Monte Carrubba Formation (Tortonian-lower Messinian) is the youngest marine Miocene carbonate deposit of the Hyblean region, prior to the Messinian crisis of the Mediterranean. In particular, Faro Santa Croce outcrop, which is in vertical thickness up to 8 m shows the most proximal sector of this ramp. The Faro Santa Croce outcrop offers the opportunity to investigate and reproduce a highly-detailed facies heterogeneity 3D model for a very narrow and limited area of few squared kilometers (0.1 Km2), developed in a tectonically stable area. Within this small areal, five facies have been recognized and modelled revealing a high level of facies heterogeneity. In this area marine ooidal shoals (ooidal grainstone to packstone) interfingered with shallow water seagrass environment (green-algal-floatstone facies and bioclastic grainstone-to-packstone facies) with abundant mollusc fauna. The distal part of this vegetated environment (fine-grained mollusc-packstone facies) passed basinward into coral mounds (coral boundstone). The combination of digital photogrammetry and 3D geological modelling software has allowed to obtain a very high-resolution model of facies heterogeneity, evidencing the complexity of facies associations and, in particular, the development of a facies mosaic that can be underestimated by a classical 1D or 2D field analysis, especially in limitedly exposed outcrops.

The aim of this work is to reproduce a metre-scale facies heterogeneity 3D model of the Chattian Porto Badisco Calcarenite carbonate ramp outcropping in the Salento Peninsula (southern Italy). However, in shallow-water carbonate systems, capturing metre-scale facies heterogeneity in three-dimensional models remains controversial due to the possibility of facies coexistence and because their association can change through time and space. Within this context, the continuous and well-exposed Chattian Porto Badisco Calcarenite carbonate ramp allows detailed study of the distribution of lithofacies association and their architecture along the dip direction depositional profile. The lithofacies and the depositional model of the Porto Badisco Calcarenite are referred to those defined by Pomar et al. (2014). The Porto Badisco Calcarenite is a homoclinal carbonate ramp with a euphotic inner setting characterised by the extensive seagrass meadows, passing basinward into a large rotaliid packstone and coral mounds developed in mesophotic conditions. The deeper part of the oligophotic zone is characterised by rhodolithic floatstone to rudstone and large lepidocyclinid packstone. The distal part of the ramp is characterise by a fine calcarenite. The methodology used in this work combines classical field data collection (e.g., stratigraphic logs and field-facies mapping) and 3D stochastic modeling by using Petrel™. All the data (top and base of stratigraphic logs, cross-section, key surfaces, lithofacies lateral extension etc.) were georeferenced and inserted into the software to build the digital outcrop model. The 3D facies model has been performed after several simulations through specific stochastic algorithms (SISim, TGSim), comparing the models reproduce by the two algorithms, matching the depositional geometries and the lithofacies association observed in the outcrop. The 3D modeling represents a useful tool to better understand the facies architecture and their complex heterogeneity. Moreover, a detailed 3D facies model provides an essential tool to characterise semi-quantitatively sedimentological features for subsurface reservoir studies.

The resilience of cooperatives and their positive contribution to employment in times of crisis is well established. However, their overall economic performance relative to conventional firms is still controversial, casting doubt on the ability of this alternative organizational form to govern the fundamental drivers of productivity. To shed new light on the issue, we study the comparative technical efficiency of agricultural cooperatives (ACs) and conventional firms (CFs), drawing on a unique data set comprising all wine‐producing companies in Sardinia (Italy) from 2004 to 2009. Due to the similarity of the habitats in which the firms operate and the careful measurement of several key inputs, the observed units are ‘twins’ in all non‐organizational respects, providing an ideal setting for comparison. Having generated efficiency scores through Data Envelopment Analysis (DEA), we regressed the scores on external covariates and ownership type using a pooled truncated maximum likelihood formulation. Our findings, which survive correction for spatial correlations, indicate that cooperatives are less technically efficient than their capitalist counterparts and struggle more to adapt to extreme weather fluctuations. Both results are particularly worrying in light of the main challenges facing the wine industry in the near future: liberalization of EU planting rights and climate change.

The Eocene-Oligocene transition marks a fundamental step in the evolution of the modern climate. This climate change and the consequent major oceanic reorganisation affected the global carbon cycle, whose dynamics across this crucial interval are far from being clearly understood. In this work, the upper Eocene to lower Oligocene δ13CCarb and δ13CTOC records of a shallow-water and a hemipelagic carbonate settings within the Central Mediterranean area have been studied and discussed. The shallow-water carbon isotope signal has been analysed in the northern portion of the Apula Platform, cropping out in the Majella Mountain, Central Apennines (Santo Spirito Formation). A coeval Umbria-Marche basinal succession has been investigated in the Massignano section (Conero area, Central Italy). The purposes of this work are: to discriminate between the global and the local (Mediterranean) signature of C-isotope record during the Oi-1 event, to correlate the regional C-isotope signal with the global record, and to evaluate the carbon cycle dynamics across the greenhouse-icehouse transition through the integration of complementary records (shallow-water vs pelagic settings, δ13CCarb vs δ13CTOC). The upper Eocene carbon isotope record of the analysed successions matches with the global signal. The overall trend shows a decrease of the δ13CCarb and a contemporary increase of the δ13CTOC. The decoupling of the two curves is consistent with a reduced fractionation effect by primary producers that characterised the interval between the Middle Eocene Climatic Optimum and the onset of the Oi-1 event. However, regional factors superimposed the global signal. In fact, the upper Eocene basinal δ13CTOC record is marked by short-term negative spikes, which possibly represent times of higher productivity triggered by the westward subtropical Eocene Neo-tethys current entering from the Arabian-Eurasian gateway. On the contrary, the shallow-water record does not display these short-term productivity pulses. A change in the carbonate factory is only recorded at the Eocene-Oligocene transition, marked by a reduction of the larger benthic foraminifera and the spread of seagrass and corals. Moreover, in the shallow-water record of the Santo Spirito Formation, no major carbon isotope shift related to the Oi-1 event is recorded due to the presence of extensive slumps that disrupt the bedding. These slumps are the main evidence of the sea-level drop that occurred concomitantly with the onset of the Antarctica ice-sheet, which caused the deepening of the storm wave base and increased the instability over the entire ramp.

Heavy oil and bitumens have been exploited in Italy during the past, in particular over the Maiella Mountain’s northwest flank (Central Italy), where relatively undeformed, hydrocarbon-bearing carbonate-ramp reservoirs of the Bolognano Formation crop out. These reservoirs represent the exhumed analog of a wider petroleum system that has been investigated also in the subsurface by exploration activities, both onshore and offshore (Central Adriatic). Here we present, for the first time, a historical data set composed of 180 shallow wells drilled over the area in 1942 by a company named Azienda Lavorazione Bitumi Asfalti; we digitally reconstructed this data set, integrating it with field observations, laboratory measurements, and thin-section analysis. Using Petrel (mark of Schlumberger) three-dimensional software, we modeled the reservoir and the hydrocarbon distribution, also calculating volumes of hydrocarbons in place. In our work, we demonstrate the presence of these quite homogeneous, porous carbonate reservoirs over the whole region, and we identify internal reservoir geometries characterized by clinoforms, likely resulting from a large-scale depositional cross-bedding and progradation. We also infer a different function of faults in the hydrocarbon accumulations: major faults were able to create independent compartments during migration, whereas minor, more recent elements did not control hydrocarbon accumulation, likely postdating a main lower-Pliocene migration phase. We believe that the observations derived from our work can represent a good analog for carbonate-ramp reservoirs elsewhere, may help in identifying appropriate modeling solutions, and can be used as calibration for future renewed exploration efforts in the region, both onshore and offshore.

The Miocene is a key interval in the geodynamic and oceanographic evolution of the Mediterranean marking the transition from a wide open basin to the modern closed basin. We used the Sr and Nd isotope records of two Miocene carbonate successions in the Adriatic to document that the evolution of the Mediterranean Basin controlled its seawater chemistry. During the late Aquitanian (similar to 21Ma), a time of glaciation and sea level lowstand, increased runoff affected the Sr isotope ratios of Mediterranean waters, whereas during the Burdigalian (20.44-15.97Ma) volcanism in the circum-Mediterranean area mainly influenced the Sr isotopic signature. During the Langhian (15.97-13.82Ma), a time of sea level highstand associated with the Middle Miocene Climatic Optimum, the Nd isotope values indicate that waters exchanged between the Paratethys and the Central Mediterranean. The Central Mediterranean was well connected with the Atlantic Ocean between the Langhian and the early Tortonian (15.97-11.5Ma), but exchange of water with the Paratethys declined. In the Messinian (6.3Ma), connections between some marginal Mediterranean basins, for example, the proto-Adriatic basin, and the Central Mediterranean, became restricted. In this basin, the Sr isotope values fell below the global reference line, while Nd isotope ratios show a strong affinity with the Atlantic Ocean and also indicate freshwater input. We conclude that the Mediterranean Nd isotope signature differs from that in the open oceans and reflects the basin physiography, reflecting a mix of signals derived from the adjacent oceans and local signals.