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Journalists from traditional outlets and new startups contemplate market value and journalistic values in an online world. Anxiety was in the air at a seminar last May sponsored by New [...]

Smooth muscle myosin II undergoes an additional movement of the regulatory domain with ADP release that is not seen with fast skeletal muscle myosin II. In this study, we have examined the interactions of smooth muscle myosin subfragment 1 with ADP to see if this additional movement corresponds to an identifiable state change. These studies indicate that for this myosin:ADP, both the catalytic site and the actin binding site can each assume one of two conformations. Relatively loose coupling between these two binding sites leads to three discrete actin-associated ADP states. After an initial, weakly bound state, binding of myosin:ADP to actin shifts the equilibrium toward a mixture of two states that each bind actin strongly, but differ in the conformation of their catalytic sites. By contrast, fast myosins, including Dictyostelium myosin II, have reciprocal coupling between the actin and ADP binding sites, so that either actin or nucleotide, but not both, can be tightly bound. This uncoupling, which generates a second strongly bound actomyosin:ADP state in smooth muscle, would prolong the fraction of the ATPase cycle time that this actomyosin spends in a force-generating conformation, and may be central to explaining the physiologic differences between this and other myosins.

Taking the high road may open more doors than you think. It's nice to be ethical, but is it ethical to be nice? Most of our mothers told us, when [...]

Sometimes our past experiences can help us in our reporting. Not all bias is bad. This message, startling to the objectivity-obsessed, is one of the key components of a workshop [...]

You may not solve them, but at least give as much time to possible solutions as you do the problems. When we were tossing around some ideas for this ethics [...]

Cops and journalists don't mix -- or do they? Out here in the wild, wild West, we had a couple of cops-'n'-crooks episodes a while back that raised ethical questions. [...]

When presentation techniques get in the way of writing, readers lose interest. Burl Bovine's rubber boots crunched through the ice covering the muddy ruts in his barnyard. The light from [...]

Lawyers and journalists sometimes have different takes on right and wrong -- and the way to correct errors. What is legal is not always ethical. And never is that more [...]

Coverage of political conventions always seems to leave someone unhappy. One test reporters use to determine whether they're doing their jobs right is if they're making everybody angry. (One of [...]

Journalists try to remain impartial. But when barricades and police lines get in the way of the job, it may be time to get involved to get the story. HOW [...]

Disclosure can sometimes mean turning in your peers. The Minnesota chapter of the Society of Professional Journalists has done something that's worth serious consideration by other chapters. It also has [...]

In Denver, many journalists are skeptical of sharing resources. The Denver Post and the Denver Rocky Mountain News have applied to the Justice Department for permission to enter into a [...]

In a profession that is granted a large degree of legal leeway, journalists need to set strong ethical standards for themselves. The media's behavior is inescapably conspicuous. When we mount [...]

Commitment to good journalism can reverse the public's mistrust. Welcome to the first issue of Quill in five years devoted to the subject of ethics. Ethics is one of the [...]

The public's perception of the media's work is revealing -- and worth hearing. The speech to the Kiwanis Club of Southwest Denver on this snowy late-January morning was supposed to [...]

Ethical answers are cloudy in the recent Columbine video case There has been no shortage or ethical dilemmas in my neck of the woods lately. The latest was Jefferson County [...]

Recent cases raise ethical questions in sports, politics and advertising In late October, along about Halloween, there were several reports of members of the news media scaring people. First came [...]

After a year of research, discussion and debate, SPJ's Strategic Planning Committee has a plan for the Society's future. The past two years have brought some important organizational changes to [...]

Discusses the telecommunications systems in operation at Buena Vista College in Iowa. Describes the systems' uses in linking all offices and classrooms on the campus, downlinking satellite communications through a dish, transmitting audio and video information to any set of defined studio or classroom space, and teleconferencing. (TW)