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102. Plasma Metabolomic Profiles of Glycemic Index, Glycemic Load, and Carbohydrate Quality Index in the PREDIMED Study

Author

Bulló, Mònica, primary, Papandreou, Christopher, additional, Ruiz-Canela, Miguel, additional, Guasch-Ferré, Marta, additional, Li, Jun, additional, Hernández-Alonso, Pablo, additional, Toledo, Estefania, additional, Liang, Liming, additional, Razquin, Cristina, additional, Corella, Dolores, additional, Estruch, Ramon, additional, Ros, Emilio, additional, Fitó, Montserrat, additional, Arós, Fernando, additional, Fiol, Miquel, additional, Serra-Majem, Lluís, additional, Clish, Clary B, additional, Becerra-Tomás, Nerea, additional, Martínez-González, Miguel A, additional, Hu, Frank B, additional, and Salas-Salvadó, Jordi, additional

Published
2021
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103. Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study

Author

Papandreou, Christopher, primary, Bulló, Mònica, additional, Hernández-Alonso, Pablo, additional, Ruiz-Canela, Miguel, additional, Li, Jun, additional, Guasch-Ferré, Marta, additional, Toledo, Estefanía, additional, Clish, Clary, additional, Corella, Dolores, additional, Estruch, Ramon, additional, Ros, Emilio, additional, Fitó, Montserrat, additional, Alonso-Gómez, Angel, additional, Fiol, Miquel, additional, Santos-Lozano, José M, additional, Serra-Majem, Lluís, additional, Liang, Liming, additional, Martínez-González, Miguel A, additional, Hu, Frank B, additional, and Salas-Salvadó, Jordi, additional

Published
2020
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104. Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial

Author

Díaz-López, Andrés, primary, Becerra-Tomás, Nerea, additional, Ruiz, Verónica, additional, Toledo, Estefanía, additional, Babio, Nancy, additional, Corella, Dolores, additional, Fíto, Montse, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M, additional, Wärnberg, Julia, additional, Martínez, J.Alfredo, additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Tinahones, Francisco J, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep, additional, López-Miranda, José, additional, Ibañez, Naomi Cano, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Paz, Jose Antonio de la, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ruiz-Canela, Miguel, additional, Bulló, Mònica, additional, Sorlí, José V, additional, Goday, Albert, additional, Fiol, Miquel, additional, García-de-la-Hera, Manoli, additional, Sierra, Lucas Tojal, additional, Pérez-Farinós, Napoleón, additional, Zulet, Maria Angeles, additional, Sánchez-Villegas, Almudena, additional, Sacanella, Emilio, additional, Fernández-García, José Carlos, additional, Santos-Lozano, José Manuel, additional, Gimenez-Gracia, Miquel, additional, Bibiloni, Maria del Mar, additional, Diez-Espino, Javier, additional, Ortega-Azorin, Carolina, additional, Castañer, Olga, additional, Morey, Marga, additional, Torres-Collado, Laura, additional, Sanchez, Carolina Sorto, additional, Muñoz, Miguel Ángel, additional, Ros, Emilio, additional, Martínez-González, Miguel A, additional, and Salas-Salvadó, Jordi, additional

Published
2020
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106. High Plasma Glutamate and a Low Glutamine-to-Glutamate Ratio Are Associated with Increased Risk of Heart Failure but Not Atrial Fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study

Author

Papandreou, Christopher, primary, Hernández-Alonso, Pablo, additional, Bulló, Mònica, additional, Ruiz-Canela, Miguel, additional, Li, Jun, additional, Guasch-Ferré, Marta, additional, Toledo, EstefanÍa, additional, Clish, Clary, additional, Corella, Dolores, additional, Estruch, Ramon, additional, Cofán, Montserrat, additional, Fitó, Montserrat, additional, Razquin, Cristina, additional, Arós, Fernando, additional, Fiol, Miquel, additional, Santos-Lozano, José M, additional, Serra-Majem, LluÍs, additional, Liang, Liming, additional, MartÍnez-González, Miguel A, additional, Hu, Frank B, additional, and Salas-Salvadó, Jordi, additional

Published
2020
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110. Plasma Metabolomics Profiles are Associated with the Amount and Source of Protein Intake: A Metabolomics Approach within the PREDIMED Study

Author

Hernández‐Alonso, Pablo, primary, Becerra‐Tomás, Nerea, additional, Papandreou, Christopher, additional, Bulló, Mònica, additional, Guasch‐Ferré, Marta, additional, Toledo, Estefanía, additional, Ruiz‐Canela, Miguel, additional, Clish, Clary B., additional, Corella, Dolores, additional, Dennis, Courtney, additional, Deik, Amy, additional, Wang, Dong D., additional, Razquin, Cristina, additional, Drouin‐Chartier, Jean‐Philippe, additional, Estruch, Ramon, additional, Ros, Emilio, additional, Fitó, Montserrat, additional, Arós, Fernando, additional, Fiol, Miquel, additional, Serra‐Majem, Lluís, additional, Liang, Liming, additional, Martínez‐González, Miguel A, additional, Hu, Frank B, additional, and Salas‐Salvadó, Jordi, additional

Published
2020
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112. A Mediterranean Diet Rich in Extra-Virgin Olive Oil Is Associated with a Reduced Prevalence of Nonalcoholic Fatty Liver Disease in Older Individuals at High Cardiovascular Risk

Author

Pintó, Xavier, primary, Fanlo-Maresma, Marta, additional, Corbella, Emili, additional, Corbella, Xavier, additional, Mitjavila, M Teresa, additional, Moreno, Juan J, additional, Casas, Rosa, additional, Estruch, Ramon, additional, Corella, Dolores, additional, Bulló, Mònica, additional, Ruiz-Canela, Miguel, additional, Castañer, Olga, additional, Martinez, J Alfredo, additional, and Ros, Emilio, additional

Published
2019
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115. Polymorphisms Cyclooxygenase-2 -765G>C and Interleukin-6 -174G>C Are Associated with Serum Inflammation Markers in a High Cardiovascular Risk Population and Do Not Modify the Response to a Mediterranean Diet Supplemented with Virgin Olive Oil or Nuts1-3

Author

Corella, Dolores, González, José Ignacio, Bulló, Mònica, Carrasco, Paula, Portolés, Olga, Díez-Espino, Javier, Covas, María Isabel, Ruíz-Gutierrez, Valentina, Gómez-Gracia, Enrique, Arós, Fernando, Fiol, Miquel, Herrera, Manuel Conde, Santos, José Manuel, Sáez, Guillermo, Lamuela, Rosa, Lahoz, Carlos, Vinyoles, Ernest, Ros, Emilio, and Estruch, Ramón

Published
2009
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116. Effect of a Mediterranean Diet Supplemented With Nuts on Metabolic Syndrome Status: One-Year Results of the PREDIMED Randomized Trial

Author

Salas-Salvadó, Jordi, Fernández-Ballart, Joan, Ros, Emilio, Martínez-González, Miguel-Angel, Fitó, Montserrat, Estruch, Ramon, Corella, Dolores, Fiol, Miquel, Gómez-Gracia, Enrique, Arós, Fernando, Flores, Gemma, Lapetra, José, Lamuela-Raventós, Rosa, Ruiz-Gutiérrez, Valentina, Bulló, Mònica, Basora, Josep, and Covas, María-Isabel

Published
2008

117. A case-control study nested in the PREDIMED trial

Author

Papandreou, Christopher, Sala-Vila, Aleix, Galié, Serena, Muralidharan, Jananee, Estruch, Ramón, Fitó, Montserrat, Razquin, Cristina, Corella, Dolores, Ros, Emilio, Timiraos, Juan, Lapetra, José, Serra-Majem, Lluis, Carlos, Silvia, Castañer, Olga, Asensio, Eva M., Salas-Salvadó, Jordi, Bulló, Mònica, Fundació La Marató de TV3, Generalitat de Catalunya, Instituto de Salud Carlos III, European Commission, and Universidad Rovira i Virgili

Subjects
Adult, Risk, heart diseases, Chromatography, Gas, Incidence, Fatty Acids, body mass index, Coronary Disease, Diet, Mediterranean, Membrane Lipids, Case-Control Studies, Confidence Intervals, Odds Ratio, Humans, cell membrane, Biomarkers, Follow-Up Studies
Abstract

[Objective]: To examine the associations between baseline levels of fatty acids in blood cell membranes and their 1-year changes with the incidence of coronary heart disease (CHD) in older adults at high cardiovascular disease risk. [Approach and Results]: This is a case-control study nested in the PREDIMED trial (Prevención con Dieta Mediterránea), with 136 CHD cases and 272 controls (matched on age, sex, body mass index, intervention group, and time of permanence in the study to the time event). We used gas chromatography to measure the proportion of 22 fatty acids in blood cell membranes at baseline and after 1 year. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% CIs. After adjustment for classical CHD risk factors and multiple testing, 1 SD increase in baseline levels of C22:0, C24:0 and the sum of individual very long chain saturated fatty acids was associated with 56% (OR, 0.44 [95% CI, 0.28–0.69]), 59% (OR, 0.41 [95% CI, 0.25–0.65]), and 55% (OR, 0.45 [95% CI, 0.29–0.70]) a decreased odds of developing CHD, respectively. Baseline C20:1n9 was associated with higher odds of CHD (OR, 1.58 [95% CI, 1.25–2.00]). [Conclusions]: Higher levels of C22:0 and C24:0 were associated with a lower CHD incidence, whereas higher levels of C20:1n9 were associated with a higher risk. This study adds to the growing body of evidence suggesting potential differences in the cardiovascular disease effects of different types of circulating saturated fatty acids., This study was funded by Fundació La Marató de TV3 (201512.30.31.32). C. Papandreou is supported by a postdoctoral fellowship granted by the Autonomous Government of Catalonia (PERIS 2016–2020 Incorporació de Científics i Tecnòlegs, SLT002/0016/00428). A. Sala-Vila holds a Miguel Servet contract (CP12/03299, Instituto de Salud Carlos III, Spain). J. Muralidharan has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 713679 and from the Universitat Rovira i Virgili (URV).

Published
2019

119. Plasma metabolites associated with homeostatic model assessment of insulin resistance:metabolite-model design and external validation

Author

Hernández-Alonso, Pablo, García-Gavilán, Jesús, Camacho-Barcia, Lucía, Sjödin, Anders Mikael, Hansen, Thea Toft, Harrold, Jo, Salas-Salvadó, Jordi, Halford, Jason C G, Canudas, Silvia, Bulló, Mònica, Hernández-Alonso, Pablo, García-Gavilán, Jesús, Camacho-Barcia, Lucía, Sjödin, Anders Mikael, Hansen, Thea Toft, Harrold, Jo, Salas-Salvadó, Jordi, Halford, Jason C G, Canudas, Silvia, and Bulló, Mònica

Abstract

Different plasma metabolites have been related to insulin resistance (IR). However, there is a lack of metabolite models predicting IR with external validation. The aim of this study is to identify a multi-metabolite model associated to the homeostatic model assessment (HOMA)-IR values. We performed a cross-sectional metabolomics analysis of samples collected from overweight and obese subjects from two independent studies. The training step was performed in 236 subjects from the SATIN study and validated in 102 subjects from the GLYNDIET study. Plasma metabolomics profile was analyzed using three different approaches: GC/quadrupole-TOF, LC/quadrupole-TOF, and nuclear magnetic resonance (NMR). Associations between metabolites and HOMA-IR were assessed using elastic net regression analysis with a leave-one-out cross validation (CV) and 100 CV runs. HOMA-IR was analyzed both as linear and categorical (median or lower versus higher than the median). Receiver operating characteristic curves were constructed based on metabolites' weighted models. A set of 30 metabolites discriminating extremes of HOMA-IR were consistently selected. These metabolites comprised some amino acids, lipid species and different organic acids. The area under the curve (AUC) for the discrimination between HOMA-IR extreme categories was 0.82 (95% CI: 0.74-0.90), based on the multi-metabolite model weighted with the regression coefficients of metabolites in the validation dataset. We identified a set of metabolites discriminating between extremes of HOMA-IR and able to predict HOMA-IR with high accuracy.

Published
2019

120. Is reduction in appetite beneficial for body weight management in the context of overweight and obesity? Yes, according to the SATIN (Satiety Innovation) study

Author

Hansen, Thea Toft, Mead, Bethan R, García-Gavilán, Jesús Francisco, Korndal, Sanne Kellebjerg, Harrold, Joanne A., Camacho-Barcía, Lucia, Ritz, Christian, Christiansen, Paul, Salas-Salvadó, Jordi, Hjorth, Mads Fiil, Blundell, John, Bulló, Mònica, Halford, Jason C G, Sjödin, Anders Mikael, Hansen, Thea Toft, Mead, Bethan R, García-Gavilán, Jesús Francisco, Korndal, Sanne Kellebjerg, Harrold, Joanne A., Camacho-Barcía, Lucia, Ritz, Christian, Christiansen, Paul, Salas-Salvadó, Jordi, Hjorth, Mads Fiil, Blundell, John, Bulló, Mònica, Halford, Jason C G, and Sjödin, Anders Mikael

Abstract

New dietary-based concepts are needed for treatment and effective prevention of overweight and obesity. The primary objective was to investigate if reduction in appetite is associated with improved weight loss maintenance. This cohort study was nested within the European Commission project Satiety Innovation (SATIN). Participants achieving ≥8% weight loss during an initial 8-week low-energy formula diet were included in a 12-week randomised double-blind parallel weight loss maintenance intervention. The intervention included food products designed to reduce appetite or matching controls along with instructions to follow national dietary guidelines. Appetite was assessed by ad libitum energy intake and self-reported appetite evaluations using visual analogue scales during standardised appetite probe days. These were evaluated at the first day of the maintenance period compared with baseline (acute effects after a single exposure of intervention products) and post-maintenance compared with baseline (sustained effects after repeated exposures of intervention products) regardless of randomisation. A total of 181 participants (forty-seven men and 134 women) completed the study. Sustained reduction in 24-h energy intake was associated with improved weight loss maintenance (R 0·37; P = 0·001), whereas the association was not found acutely (P = 0·91). Suppression in self-reported appetite was associated with improved weight loss maintenance both acutely (R −0·32; P = 0·033) and sustained (R −0·33; P = 0·042). Reduction in appetite seems to be associated with improved body weight management, making appetite-reducing food products an interesting strategy for dietary-based concepts.

Published
2019

121. Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet

Author

Hansen, Thea Toft, Hjorth, Mads Fiil, Sandby, Karoline, Andersen, Sarah Vold, Astrup, Arne, Ritz, Christian, Bulló, Mònica, Camacho-Barcía, Maria Lucia, García-Gavilán, Jesús Francisco, Salas-Salvadó, Jordi, Harrold, Joanne A, Halford, Jason C G, Sjödin, Anders Mikael, Hansen, Thea Toft, Hjorth, Mads Fiil, Sandby, Karoline, Andersen, Sarah Vold, Astrup, Arne, Ritz, Christian, Bulló, Mònica, Camacho-Barcía, Maria Lucia, García-Gavilán, Jesús Francisco, Salas-Salvadó, Jordi, Harrold, Joanne A, Halford, Jason C G, and Sjödin, Anders Mikael

Abstract

A low-energy diet (LED) is an effective approach to induce a rapid weight loss in individuals with overweight. However, reported disproportionally large losses of fat-free mass (FFM) after an LED trigger the question of adequate protein content. Additionally, not all individuals have the same degree of weight loss success. After an 8-week LED providing 5020 kJ/d for men and 4184 kJ/d for women (84/70 g protein/d) among overweight and obese adults, we aimed to investigate the relationship between protein intake relative to initial FFM and proportion of weight lost as FFM as well as the individual characteristics associated with weight loss success. We assessed all outcomes baseline and after the LED. A total of 286 participants (sixty-four men and 222 women) initiated the LED of which 82 % completed and 70 % achieved a substantial weight loss (defined as ≥8 %). Protein intake in the range 1·0-1·6 g protein/d per kg FFM at baseline for men and 1·1-2·2 g protein/d per kg FFM at baseline for women was not associated with loss of FFM (P = 0·632). Higher Three-Factor Eating Questionnaire (TFEQ) hunger at baseline and reductions in TFEQ disinhibition and hunger during the LED were associated with larger weight loss (all P ≤ 0·020); whereas lower sleep quality at baseline predicted less successful weight loss using intention to treat analysis (P = 0·021), possibly driven by those dropping out (n 81, P = 0·067 v. completers: n 198, P = 0·659). Thus, the protein intakes relative to initial FFM were sufficient for maintenance of FFM and specific eating behaviour characteristics were associated with weight loss success.

Published
2019

122. Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies

Author

Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat de Catalunya, Generalitat Valenciana, Diputación Foral de Navarra, García-Arellano, Ana, Martínez-González, Miguel Ángel, Ramallal, Raúl, Salas-Salvadó, Jordi, Hébert, James R., Corella, Dolores, Shivappa, Nitin, Forga, Luis, Schröder, Helmut, Muñoz-Bravo, C., Estruch, Ramón, Hernández, P., Murillo, C., Mestres, G., Mengual, L., Serra-Majem, Lluis, Juan, C.de, Romaguera, Dora, Ruiz-Canela, Miguel, Vizcaíno, J., Bautista Castaño, I., Mendonça, Raquel Bicudo Deus, Farré, M., Basora-Gallisa, J., Barrio López, M.T., Buil-Cosiales, Pilar, Sarmiendo de la Fe, F., Medina-Remón, Alexander, Sánchez Luque, J. J., Sorlí, J., Cervantes, S., Pérez-Heras, A., Gil Zarzosa, J., Villanueva Moreno, R., Goni-Ochandorena, E., Lasanta-Sáez, M.J., Cia-Lecumberri, P., Fernandez-Urzainqui, L., Sáiz, C., Schroder, H., Carrasco, P., Doménech, M., Mellado, L., Toledo-Atucha, J., Guillen-Grima, F., Marrugat, J., Sáez, G., Ruiz Zambrana, A., Miró-Moriano, L., Zazpe Garcia, I, Godoy, D., Segarra, R., Toledo, Estefania, Molina, C., Loma-Osorio, A., Martínez, E., Bulló, Mònica, Vinyoles, E., Estremera-Urabayen, J. V., García, Y., Simón, C., Amorós, M., Navajas, R., Sánchez-Navarro, S., Casi, A., Pimenta, A. M., Tabar-Sarrias, J. A., Cruz, E. de la, Pascual-Pascual, P., Riera, C., García-Pérez, L., Carratalá-Calvo, A., Sanchez-Tainta, A., Ariz-Arnedo, M.J., Galera, A., Arina-Vergara, E., Martínez-González, José, Munuera, S., Francés, F., Felipe, I., Martínez, P., Gea, A., Díaz-López, A., Santana Santana, A. J., Serra-Mir, Mercè, Ros, Emilio, Villanueva, P., Becerra-Tomás, Nerea, Rosique-Esteban, N., Papandreou, Christopher, García, J., Prieto, R., Bestard, F., Osma, R., Baena, J.M., Figuerido-Garmendia, E., Pla, I., Tafalla, M., Benavent, J., Sánchez, M. S., Proenza, A., García, M., Vivo, M., Garcés Ducar, M. L., Bonet, M.T., Casas, Ricard, Bobe, I., Altés, A., Ginard, M., Díez-Espino, Javier, López-Sabater, M. C., Wärnberg, Julia, Valls-Pedret, C., Basells, J., Serrano-Martinez, M., Giménez, F.J., Velasco García, V., González, R., González, J. I., Barragán, Rocío, Martín, F., Muñoz-Aguayo, Daniel, Elosua, Roberto, Rovira, A., Fernández-Rodríguez, M. J., Román, Pablo, Quifer-Rada, P., Fernández-Crehuet, Joaquín, Llorca, J., Tort, N., Iglesias, P., Clos, J., Ferreira, C., Lopez del Burgo, C., Llauradó, M., Sarasa, Iziar, Jover, A., Altirriba, J., Bianchi Alba, M., Lahortiga, F., García-Rodriguez, A., Cabeza-Beunza, J. A., Fernández-Ballart, J., Pascual, V., Pages, M.A., del Hierro, T., Mata, M., Corbella, X., García, L., Maestre, E., Barcena, A. F., Sorlí, José V., Carlos, Silvia, Balanza, R., Rodríguez, M. A., Pedret, R., Castañer, Olga, Oreja-Arrayago, C., Ortega-Azorín, Carolina, Cervello, T., Maldonado Díaz, I., Ramos, A., Gómez-Huelgas, R., García Roselló, J., Benito Crochon, S., Arroyo-Azpa, C., Guillén, M., Martín, M. T., Coltell, O., García-Valdueza, M., Frontera, G., Fernandez Montero, A., Rosa, Pedro Antonio de la, Tur, Josep A., Díez Benítez, E., Razquin, Cristina, Molina, N., Salaverria Lete, Itziar, Amat, J., Alonso, A., Araque, M., Fernández-Carrión, Rebeca, Montull, I., Asensio, Eva M., Algorta, J., Portolés, Olga, Duaso, I., Sanz, E., Donat-Vargas, Carolina, Sayón-Orea, Carmen, Guarner, A., Fiol, F., Guasch‐Ferré, Marta, Simón García, C., Oller, M., Brau, A., Benítez Pont, R., Sánchez-Villegas, A., Diego Salas, J. de, Domínguez-Espinaco, C., Vaquero-Díaz, S., Lozano-Rodríguez, J.M., Marti, A., Núñez-Córdoba, J.M., Vázquez Ruiz, Z., Roura, P., Babio, Nancy, Baca Osorio, A., Valero-Barcelo, C., Basterra-Gortari, F. Javier, Salas-Huetos, A., Munar, J.A., Elcarte-Lopez, T., Donazar, M., San Vicente, J., Santamaria, M. I., Isach, A., Yuste, M. C., Ortega-Calvo, Manuel, Pintó-Salas, X., Trias, Ferrán, Muñoz, Miguel Ángel, Viñas, C., Esparza-López, J.M., Martínez-Mazo, M.D., Bes-Rastrollo, M., Vila, J., Castellote-Bargalló, Ana I., Leal, M., Artal-Moneva, F., Coll, L., Lamuela-Raventós, Rosa M., Torre, Rafael de la, Tresserra-Rimbau, A., Quinzavos, L., Sanjulian, B., Macua-Martínez, T., Irala, J. de, Sala-Vila, Aleix, Tello, S., Beunza, J.J., Francisco, S., Falcón Sanabria, I., Díaz, A., Solis, E., Lapetra, José, Mena, G., Liroz, M., Manzano, E., Corchado, Y., Goday, A., Gonzaláz-Monje, I., Rovira, M.A., Iglesias, C., Macías Gutiérrez, B., Parra, L., Álvarez-Pérez, J., Cabezas, C., Quiles, L., Baby, P., Ibarrola-Jurado, Nuria, Cabre, M., Parra-Osés, A., Cofán, Montserrat, Fuente, Carmen de la, Santos-Lozano, J. M., Guillem-Saiz, P., Martínez, J. A., Fernández, M., Mari-Sanchıs, A., Rico, A., Giardina, S., Canudas, Silvia, Paris, F., Marti Massó, R., Gutierrez, E., Corbella, Emili, Fiol, Miquel, Vargas López, E., Portillo, María P., Rekondo, Javier, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat de Catalunya, Generalitat Valenciana, Diputación Foral de Navarra, García-Arellano, Ana, Martínez-González, Miguel Ángel, Ramallal, Raúl, Salas-Salvadó, Jordi, Hébert, James R., Corella, Dolores, Shivappa, Nitin, Forga, Luis, Schröder, Helmut, Muñoz-Bravo, C., Estruch, Ramón, Hernández, P., Murillo, C., Mestres, G., Mengual, L., Serra-Majem, Lluis, Juan, C.de, Romaguera, Dora, Ruiz-Canela, Miguel, Vizcaíno, J., Bautista Castaño, I., Mendonça, Raquel Bicudo Deus, Farré, M., Basora-Gallisa, J., Barrio López, M.T., Buil-Cosiales, Pilar, Sarmiendo de la Fe, F., Medina-Remón, Alexander, Sánchez Luque, J. J., Sorlí, J., Cervantes, S., Pérez-Heras, A., Gil Zarzosa, J., Villanueva Moreno, R., Goni-Ochandorena, E., Lasanta-Sáez, M.J., Cia-Lecumberri, P., Fernandez-Urzainqui, L., Sáiz, C., Schroder, H., Carrasco, P., Doménech, M., Mellado, L., Toledo-Atucha, J., Guillen-Grima, F., Marrugat, J., Sáez, G., Ruiz Zambrana, A., Miró-Moriano, L., Zazpe Garcia, I, Godoy, D., Segarra, R., Toledo, Estefania, Molina, C., Loma-Osorio, A., Martínez, E., Bulló, Mònica, Vinyoles, E., Estremera-Urabayen, J. V., García, Y., Simón, C., Amorós, M., Navajas, R., Sánchez-Navarro, S., Casi, A., Pimenta, A. M., Tabar-Sarrias, J. A., Cruz, E. de la, Pascual-Pascual, P., Riera, C., García-Pérez, L., Carratalá-Calvo, A., Sanchez-Tainta, A., Ariz-Arnedo, M.J., Galera, A., Arina-Vergara, E., Martínez-González, José, Munuera, S., Francés, F., Felipe, I., Martínez, P., Gea, A., Díaz-López, A., Santana Santana, A. J., Serra-Mir, Mercè, Ros, Emilio, Villanueva, P., Becerra-Tomás, Nerea, Rosique-Esteban, N., Papandreou, Christopher, García, J., Prieto, R., Bestard, F., Osma, R., Baena, J.M., Figuerido-Garmendia, E., Pla, I., Tafalla, M., Benavent, J., Sánchez, M. S., Proenza, A., García, M., Vivo, M., Garcés Ducar, M. L., Bonet, M.T., Casas, Ricard, Bobe, I., Altés, A., Ginard, M., Díez-Espino, Javier, López-Sabater, M. C., Wärnberg, Julia, Valls-Pedret, C., Basells, J., Serrano-Martinez, M., Giménez, F.J., Velasco García, V., González, R., González, J. I., Barragán, Rocío, Martín, F., Muñoz-Aguayo, Daniel, Elosua, Roberto, Rovira, A., Fernández-Rodríguez, M. J., Román, Pablo, Quifer-Rada, P., Fernández-Crehuet, Joaquín, Llorca, J., Tort, N., Iglesias, P., Clos, J., Ferreira, C., Lopez del Burgo, C., Llauradó, M., Sarasa, Iziar, Jover, A., Altirriba, J., Bianchi Alba, M., Lahortiga, F., García-Rodriguez, A., Cabeza-Beunza, J. A., Fernández-Ballart, J., Pascual, V., Pages, M.A., del Hierro, T., Mata, M., Corbella, X., García, L., Maestre, E., Barcena, A. F., Sorlí, José V., Carlos, Silvia, Balanza, R., Rodríguez, M. A., Pedret, R., Castañer, Olga, Oreja-Arrayago, C., Ortega-Azorín, Carolina, Cervello, T., Maldonado Díaz, I., Ramos, A., Gómez-Huelgas, R., García Roselló, J., Benito Crochon, S., Arroyo-Azpa, C., Guillén, M., Martín, M. T., Coltell, O., García-Valdueza, M., Frontera, G., Fernandez Montero, A., Rosa, Pedro Antonio de la, Tur, Josep A., Díez Benítez, E., Razquin, Cristina, Molina, N., Salaverria Lete, Itziar, Amat, J., Alonso, A., Araque, M., Fernández-Carrión, Rebeca, Montull, I., Asensio, Eva M., Algorta, J., Portolés, Olga, Duaso, I., Sanz, E., Donat-Vargas, Carolina, Sayón-Orea, Carmen, Guarner, A., Fiol, F., Guasch‐Ferré, Marta, Simón García, C., Oller, M., Brau, A., Benítez Pont, R., Sánchez-Villegas, A., Diego Salas, J. de, Domínguez-Espinaco, C., Vaquero-Díaz, S., Lozano-Rodríguez, J.M., Marti, A., Núñez-Córdoba, J.M., Vázquez Ruiz, Z., Roura, P., Babio, Nancy, Baca Osorio, A., Valero-Barcelo, C., Basterra-Gortari, F. Javier, Salas-Huetos, A., Munar, J.A., Elcarte-Lopez, T., Donazar, M., San Vicente, J., Santamaria, M. I., Isach, A., Yuste, M. C., Ortega-Calvo, Manuel, Pintó-Salas, X., Trias, Ferrán, Muñoz, Miguel Ángel, Viñas, C., Esparza-López, J.M., Martínez-Mazo, M.D., Bes-Rastrollo, M., Vila, J., Castellote-Bargalló, Ana I., Leal, M., Artal-Moneva, F., Coll, L., Lamuela-Raventós, Rosa M., Torre, Rafael de la, Tresserra-Rimbau, A., Quinzavos, L., Sanjulian, B., Macua-Martínez, T., Irala, J. de, Sala-Vila, Aleix, Tello, S., Beunza, J.J., Francisco, S., Falcón Sanabria, I., Díaz, A., Solis, E., Lapetra, José, Mena, G., Liroz, M., Manzano, E., Corchado, Y., Goday, A., Gonzaláz-Monje, I., Rovira, M.A., Iglesias, C., Macías Gutiérrez, B., Parra, L., Álvarez-Pérez, J., Cabezas, C., Quiles, L., Baby, P., Ibarrola-Jurado, Nuria, Cabre, M., Parra-Osés, A., Cofán, Montserrat, Fuente, Carmen de la, Santos-Lozano, J. M., Guillem-Saiz, P., Martínez, J. A., Fernández, M., Mari-Sanchıs, A., Rico, A., Giardina, S., Canudas, Silvia, Paris, F., Marti Massó, R., Gutierrez, E., Corbella, Emili, Fiol, Miquel, Vargas López, E., Portillo, María P., and Rekondo, Javier

Abstract

[Background]: Inflammation is known to be related to the leading causes of death including cardiovascular disease, several types of cancer, obesity, type 2 diabetes, depression-suicide and other chronic diseases. In the context of whole dietary patterns, the Dietary Inflammatory Index (DII®) was developed to appraise the inflammatory potential of the diet. [Objective]: We prospectively assessed the association between DII scores and all-cause mortality in two large Spanish cohorts and valuated the consistency of findings across these two cohorts and results published based on other cohorts., [Design]: We assessed 18,566 participants in the “Seguimiento Universidad de Navarra” (SUN) cohort followed-up during 188,891 person-years and 6790 participants in the “PREvencion con DIeta MEDiterránea” (PREDIMED) randomized trial representing 30,233 person-years of follow-up. DII scores were calculated in both cohorts from validated FFQs. Higher DII scores corresponded to more proinflammatory diets. A total of 230 and 302 deaths occurred in SUN and PREDIMED, respectively. In a random-effect meta-analysis we included 12 prospective studies (SUN, PREDIMED and 10 additional studies) that assessed the association between DII scores and all-cause mortality., [Results]: After adjusting for a wide array of potential confounders, the comparison between extreme quartiles of the DII showed a positive and significant association with all-cause mortality in both the SUN (hazard ratio [HR] = 1.85; 95% CI: 1.15, 2.98; P-trend = 0.004) and the PREDIMED cohort (HR = 1.42; 95% CI: 1.00, 2.02; P-trend = 0.009). In the meta-analysis of 12 cohorts, the DII was significantly associated with an increase of 23% in all-cause mortality (95% CI: 16%–32%, for the highest vs lowest category of DII)., [Conclusion]: Our results provide strong and consistent support for the hypothesis that a pro-inflammatory diet is associated with increased all-cause mortality. The SUN cohort and PREDIMED trial were registered at clinicaltrials.gov as NCT02669602 and at isrctn.com as ISRCTN35739639, respectively.

Published
2019

123. Plasma Metabolites Associated with Coffee Consumption: A Metabolomic Approach within the PREDIMED Study

Author

National Institutes of Health (US), Ministerio de Sanidad, Servicios Sociales e Igualdad (España), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Generalitat de Catalunya, Generalitat Valenciana, European Foundation for the Study of Diabetes, Institut d'Investigació Sanitària Pere Virgili, Papandreou, Christopher, Hernández-Alonso, Pablo, Bulló, Mònica, Ruiz‐Canela, Miguel, Yu, Edward, Guasch‐Ferré, Marta, Toledo, Estefania, Dennis, Courtney, Deik, Amy, Clish, Clary B., Razquin, Cristina, Corella, Dolores, Estruch, Ramón, Ros, Emilio, Fitó, Montserrat, Arós, Fernando, Fiol, Miquel, Lapetra, José, Ruano, Cristina, Liang, Liming, Martínez-González, Miguel Ángel, Hu, Frank B., Salas-Salvadó, Jordi, National Institutes of Health (US), Ministerio de Sanidad, Servicios Sociales e Igualdad (España), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Generalitat de Catalunya, Generalitat Valenciana, European Foundation for the Study of Diabetes, Institut d'Investigació Sanitària Pere Virgili, Papandreou, Christopher, Hernández-Alonso, Pablo, Bulló, Mònica, Ruiz‐Canela, Miguel, Yu, Edward, Guasch‐Ferré, Marta, Toledo, Estefania, Dennis, Courtney, Deik, Amy, Clish, Clary B., Razquin, Cristina, Corella, Dolores, Estruch, Ramón, Ros, Emilio, Fitó, Montserrat, Arós, Fernando, Fiol, Miquel, Lapetra, José, Ruano, Cristina, Liang, Liming, Martínez-González, Miguel Ángel, Hu, Frank B., and Salas-Salvadó, Jordi

Abstract

Few studies have examined the association of a wide range of metabolites with total and subtypes of coffee consumption. The aim of this study was to investigate associations of plasma metabolites with total, caffeinated, and decaffeinated coffee consumption. We also assessed the ability of metabolites to discriminate between coffee consumption categories. This is a cross-sectional analysis of 1664 participants from the PREDIMED study. Metabolites were semiquantitatively profiled using a multiplatform approach. Consumption of total coffee, caffeinated coffee and decaffeinated coffee was assessed by using a validated food frequency questionnaire. We assessed associations between 387 metabolite levels with total, caffeinated, or decaffeinated coffee consumption (≥50 mL coffee/day) using elastic net regression analysis. Ten-fold cross-validation analyses were used to estimate the discriminative accuracy of metabolites for total and subtypes of coffee. We identified different sets of metabolites associated with total coffee, caffeinated and decaffeinated coffee consumption. These metabolites consisted of lipid species (e.g., sphingomyelin, phosphatidylethanolamine, and phosphatidylcholine) or were derived from glycolysis (alpha-glycerophosphate) and polyphenol metabolism (hippurate). Other metabolites included caffeine, 5-acetylamino-6-amino-3-methyluracil, cotinine, kynurenic acid, glycocholate, lactate, and allantoin. The area under the curve (AUC) was 0.60 (95% CI 0.56–0.64), 0.78 (95% CI 0.75–0.81) and 0.52 (95% CI 0.49–0.55), in the multimetabolite model, for total, caffeinated, and decaffeinated coffee consumption, respectively. Our comprehensive metabolic analysis did not result in a new, reliable potential set of metabolites for coffee consumption.

Published
2019

124. MetProc: Separating Measurement Artifacts from True Metabolites in an Untargeted Metabolomics Experiment

Author

National Institutes of Health (US), Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Red Temática de Investigación Cooperativa en Cáncer (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Fundación Mapfre, Junta de Andalucía, Generalitat de Catalunya, Generalitat Valenciana, Nafarroako Gobernua, Chaffin, Mark D., Cao, Liu, Seik, Amy A., Clish, Clary B., Hu, Frank B., Martínez-García, Miguel Ángel, Razquin, Cristina, Bulló, Mònica, Corella, Dolores, Gómez-Gracia, Enrique, Fiol, Miquel, Estruch, Ramón, Lapetra, José, Fitó, Montserrat, Arós, Fernando, Serra-Majem, Lluis, Ros, Emilio, Liang, Liming, National Institutes of Health (US), Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Red Temática de Investigación Cooperativa en Cáncer (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Fundación Mapfre, Junta de Andalucía, Generalitat de Catalunya, Generalitat Valenciana, Nafarroako Gobernua, Chaffin, Mark D., Cao, Liu, Seik, Amy A., Clish, Clary B., Hu, Frank B., Martínez-García, Miguel Ángel, Razquin, Cristina, Bulló, Mònica, Corella, Dolores, Gómez-Gracia, Enrique, Fiol, Miquel, Estruch, Ramón, Lapetra, José, Fitó, Montserrat, Arós, Fernando, Serra-Majem, Lluis, Ros, Emilio, and Liang, Liming

Abstract

High-throughput metabolomics using liquid chromatography and mass spectrometry (LC/MS) provides a useful method to identify biomarkers of disease and explore biological systems. However, the majority of metabolic features detected from untargeted metabolomics experiments have unknown ion signatures, making it critical that data should be thoroughly quality controlled to avoid analyzing false signals. Here, we present a postalignment method relying on intermittent pooled study samples to separate genuine metabolic features from potential measurement artifacts. We apply the method to lipid metabolite data from the PREDIMED (PREvención con DIeta MEDi-terránea) study to demonstrate clear removal of measurement artifacts. The method is publicly available as the R package MetProc, available on CRAN under the GPL-v2 license.

Published
2019

125. Effect of a Nutritional and Behavioral Intervention on Energy-Reduced Mediterranean Diet Adherence Among Patients With Metabolic SyndromeInterim Analysis of the PREDIMED-Plus Randomized Clinical Trial

Author

European Research Council, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, International Nut and Dried Fruit, AstraZeneca, Junta de Andalucía, Generalitat Valenciana, Govern de les Illes Balears, Sayón-Orea, Carmen, Razquin, Cristina, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Ruiz-Canela, Miguel, Sorlí, José V., Castañer, Olga, Fiol, Miquel, Navarrete-Muñoz, María A., Arós, Fernando, Gómez-Gracia, Enrique, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bouzas, Cristina, García-Arellano, Ana, Basora, Josep, Asensio, Eva M., Schröder, Helmut, Moñino, Manuel, García-de-la-Hera, Manoli, Tojal Sierra, Lucas, Toledo, Estefania, Díaz-López, Andrés, Goday, Alberto, Salas-Salvadó, Jordi, Martínez-González, Miguel Ángel, European Research Council, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, International Nut and Dried Fruit, AstraZeneca, Junta de Andalucía, Generalitat Valenciana, Govern de les Illes Balears, Sayón-Orea, Carmen, Razquin, Cristina, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Ruiz-Canela, Miguel, Sorlí, José V., Castañer, Olga, Fiol, Miquel, Navarrete-Muñoz, María A., Arós, Fernando, Gómez-Gracia, Enrique, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bouzas, Cristina, García-Arellano, Ana, Basora, Josep, Asensio, Eva M., Schröder, Helmut, Moñino, Manuel, García-de-la-Hera, Manoli, Tojal Sierra, Lucas, Toledo, Estefania, Díaz-López, Andrés, Goday, Alberto, Salas-Salvadó, Jordi, and Martínez-González, Miguel Ángel

Abstract

[Importance] High-quality dietary patterns may help prevent chronic disease, but limited data exist from randomized trials about the effects of nutritional and behavioral interventions on dietary changes., [Objective] To assess the effect of a nutritional and physical activity education program on dietary quality., [Design, Setting, and Participants] Preliminary exploratory interim analysis of an ongoing randomized trial. In 23 research centers in Spain, 6874 men and women aged 55 to 75 years with metabolic syndrome and no cardiovascular disease were enrolled in the trial between September 2013 and December 2016, with final data collection in March 2019., [Interventions] Participants were randomized to an intervention group that encouraged an energy-reduced Mediterranean diet, promoted physical activity, and provided behavioral support (n = 3406) or to a control group that encouraged an energy-unrestricted Mediterranean diet (n = 3468). All participants received allotments of extra-virgin olive oil (1 L/mo) and nuts (125 g/mo) for free., [Main Outcomes and Measures] The primary outcome was 12-month change in adherence based on the energy-reduced Mediterranean diet (er-MedDiet) score (range, 0-17; higher scores indicate greater adherence; minimal clinically important difference, 1 point)., [Results] Among 6874 randomized participants (mean [SD] age, 65.0 [4.9] years; 3406 [52%] men), 6583 (96%) completed the 12-month follow-up and were included in the main analysis. The mean (SD) er-MedDiet score was 8.5 (2.6) at baseline and 13.2 (2.7) at 12 months in the intervention group (increase, 4.7 [95% CI, 4.6-4.8]) and 8.6 (2.7) at baseline and 11.1 (2.8) at 12 months in the control group (increase, 2.5 [95% CI, 2.3-2.6]) (between-group difference, 2.2 [95% CI, 2.1-2.4]; P < .001)., [Conclusions and Relevance] In this preliminary analysis of an ongoing trial, an intervention that encouraged an energy-reduced Mediterranean diet and physical activity, compared with advice to follow an energy-unrestricted Mediterranean diet, resulted in a significantly greater increase in diet adherence after 12 months. Further evaluation of long-term cardiovascular effects is needed., [Trial Registration] isrctn.com Identifier: ISRCTN89898870.

Published
2019

126. Plasma Acylcarnitines and Risk of Type 2 Diabetes in a Mediterranean Population at High Cardiovascular Risk

Author

National Institutes of Health (US), Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Fundación Mapfre, American Diabetes Association, Nafarroako Gobernua, Guasch‐Ferré, Marta, Ruiz-Canela, Miguel, Li, Jun, Zheng, Yan, Bulló, Mònica, Wang, Dong D., Toledo, Estefania, Clish, Clary B., Corella, Dolores, Estruch, Ramón, Ros, Emilio, Fitó, Montserrat, Arós, Fernando, Fiol, Miquel, Lapetra, José, Serra-Majem, Lluis, Liang, Liming, Papandreou, Christopher, Dennis, Courtney, Martínez-González, Miguel Ángel, Hu, Frank B., Salas-Salvadó, Jordi, National Institutes of Health (US), Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Fundación Mapfre, American Diabetes Association, Nafarroako Gobernua, Guasch‐Ferré, Marta, Ruiz-Canela, Miguel, Li, Jun, Zheng, Yan, Bulló, Mònica, Wang, Dong D., Toledo, Estefania, Clish, Clary B., Corella, Dolores, Estruch, Ramón, Ros, Emilio, Fitó, Montserrat, Arós, Fernando, Fiol, Miquel, Lapetra, José, Serra-Majem, Lluis, Liang, Liming, Papandreou, Christopher, Dennis, Courtney, Martínez-González, Miguel Ángel, Hu, Frank B., and Salas-Salvadó, Jordi

Abstract

[Context] The potential associations between acylcarnitine profiles and incidence of type 2 diabetes (T2D) and whether acylcarnitines can be used to improve diabetes prediction remain unclear., [Objective] To evaluate the associations between baseline and 1-year changes in acylcarnitines and their diabetes predictive ability beyond traditional risk factors., [Design, Setting, and Participants] We designed a case-cohort study within the PREDIMED Study including all incident cases of T2D (n = 251) and 694 randomly selected participants at baseline (follow-up, 3.8 years). Plasma acylcarnitines were measured using a targeted approach by liquid chromatography–tandem mass spectrometry. We tested the associations between baseline and 1-year changes in individual acylcarnitines and T2D risk using weighted Cox regression models. We used elastic net regressions to select acylcarnitines for T2D prediction and compute a weighted score using a cross-validation approach., [Results] An acylcarnitine profile, especially including short- and long-chain acylcarnitines, was significantly associated with a higher risk of T2D independent of traditional risk factors. The relative risks of T2D per SD increment of the predictive model scores were 4.03 (95% CI, 3.00 to 5.42; P < 0.001) for the conventional model and 4.85 (95% CI, 3.65 to 6.45; P < 0.001) for the model including acylcarnitines, with a hazard ratio of 1.33 (95% CI, 1.08 to 1.63; P < 0.001) attributed to the acylcarnitines. Including the acylcarnitines into the model did not significantly improve the area under the receiver operator characteristic curve (0.86 to 0.88, P = 0.61). A 1-year increase in C4OH-carnitine was associated with higher risk of T2D [per SD increment, 1.44 (1.03 to 2.01)]., [Conclusions] An acylcarnitine profile, mainly including short- and long-chain acylcarnitines, was significantly associated with higher T2D risk in participants at high cardiovascular risk. The inclusion of acylcarnitines into the model did not significantly improve the T2D prediction C-statistics beyond traditional risk factors, including fasting glucose.

Published
2019

127. Effects of a Mediterranean Eating Plan on the Need for Glucose-Lowering Medications in Participants With Type 2 Diabetes: A Subgroup Analysis of the PREDIMED Trial

Author

Basterra-Gortari, F. Javier, Ruiz-Canela, Miguel, Martínez-González, Miguel Ángel, Babio, Nancy, Sorlí, José V., Fitó, Montserrat, Ros, Emilio, Gómez-Gracia, Enrique, Fiol, Miquel, Lapetra, José, Estruch, Ramón, Serra-Majem, Lluis, Pintó, Xavier, González, José I., Bulló, Mònica, Castañer, Olga, Alonso-Gómez, Ángel M., Forga, Luis, Arós, Fernando, Basterra-Gortari, F. Javier, Ruiz-Canela, Miguel, Martínez-González, Miguel Ángel, Babio, Nancy, Sorlí, José V., Fitó, Montserrat, Ros, Emilio, Gómez-Gracia, Enrique, Fiol, Miquel, Lapetra, José, Estruch, Ramón, Serra-Majem, Lluis, Pintó, Xavier, González, José I., Bulló, Mònica, Castañer, Olga, Alonso-Gómez, Ángel M., Forga, Luis, and Arós, Fernando

Abstract

[Objective]: To examine the effects of two Mediterranean eating plans (Med-EatPlans) versus a low-fat eating plan on the need for glucose-lowering medications. [Research design and methods]: From the Prevención con Dieta Mediterránea (PREDIMED) trial, we selected 3,230 participants with type 2 diabetes at baseline. These participants were randomly assigned to one of three eating plans: Med-EatPlan supplemented with extra-virgin olive oil (EVOO), Med-EatPlan supplemented with mixed nuts, or a low-fat eating plan (control). In a subgroup (15%), the allocation was done in small clusters instead of using individual randomization, and the clustering effect was taken into account in the statistical analysis. In multivariable time-to-event survival models, we assessed two outcomes: 1) introduction of the first glucose-lowering medication (oral or injectable) among participants on lifestyle management at enrollment and 2) insulin initiation. [Results]: After a median follow-up of 3.2 years, in multivariable analyses adjusting for baseline characteristics and propensity scores, the hazard ratios (HRs) of starting a first glucose-lowering medication were 0.78 (95% CI 0.62–0.98) for Med-EatPlan + EVOO and 0.89 (0.71–1.12) for Med-EatPlan + nuts, compared with the control eating plan. After a median follow-up of 5.1 years, the adjusted HRs of starting insulin treatment were 0.87 (0.68–1.11) for Med-EatPlan + EVOO and 0.89 (0.69–1.14) for Med-EatPlan + nuts compared with the control eating plan. [Conclusions]: Among participants with type 2 diabetes, a Med-EatPlan + EVOO may delay the introduction of new-onset glucose-lowering medications. The Med-EatPlan did not result in a significantly lower need for insulin.

Published
2019

128. Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial

Author

National Institutes of Health (US), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Generalitat Valenciana, American Diabetes Association, Yu, Edward, Ruiz‐Canela, Miguel, Razquin, Cristina, Guasch‐Ferré, Marta, Toledo, Estefania, Wang, Dong D., Papandreou, Christopher, Dennis, Courtney, Clish, Clary B., Liang, Liming, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Gutiérrez‐Bedmar, Mario, Lapetra, José, Estruch, Ramón, Ros, Emilio, Cofán, Montserrat, Arós, Fernando, Romaguera, Dora, Serra-Majem, Lluis, Sorlí, José V., Salas-Salvadó, Jordi, Hu, Frank B., Martínez-González, Miguel Ángel, National Institutes of Health (US), Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Generalitat Valenciana, American Diabetes Association, Yu, Edward, Ruiz‐Canela, Miguel, Razquin, Cristina, Guasch‐Ferré, Marta, Toledo, Estefania, Wang, Dong D., Papandreou, Christopher, Dennis, Courtney, Clish, Clary B., Liang, Liming, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Gutiérrez‐Bedmar, Mario, Lapetra, José, Estruch, Ramón, Ros, Emilio, Cofán, Montserrat, Arós, Fernando, Romaguera, Dora, Serra-Majem, Lluis, Sorlí, José V., Salas-Salvadó, Jordi, Hu, Frank B., and Martínez-González, Miguel Ángel

Abstract

The associations between arginine‐based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case‐cohort design, nested within the PREDIMED trial, to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA] and N‐monomethyl‐l‐arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. The 1‐year changes in arginine (adjusted hazard ratio [HR] per SD 0.68, 95% confidence interval [CI] 0.49, 0.95; Q4 vs. Q1 0.46, 95% CI 0.21, 1.04; P trend = 0.02) and arginine/ADMA ratio (adjusted HR per SD 0.73, 95% CI 0.51, 1.04; Q4 vs. Q1 0.52, 95% CI 0.22, 1.25; P trend = 0.04) were associated with a lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine + citrulline) were associated with concurrent 1‐year changes in homeostatic model assessment of insulin resistance. Individuals in the low‐fat‐diet group had a higher risk of T2D for 1‐year changes in NMMA than individuals in Mediterranean‐diet groups (P interaction = 0.02). We conclude that arginine bioavailability is important in T2D pathophysiology.

Published
2019

129. Long Daytime Napping Is Associated with Increased Adiposity and Type 2 Diabetes in an Elderly Population with Metabolic Syndrome

Author

Instituto de Salud Carlos III, European Commission, European Research Council, Fundación la Caixa, Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Fundació Institut d'Investigació Sanitària Illes Balears, Papandreou, Christopher, Díaz-López, Andrés, Babio, Nancy, Martínez-García, Miguel Ángel, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Becerra-Tomás, Nerea, Martínez-Lacruz, Raúl, Schröder, Helmut, Konieczna, Jadwiga, García-de-la-Hera, Manoli, Moreno-Rodríguez, Anai, Barón-López, Javier, Pérez-Farinós, Napoleón, Abete, Itziar, Bautista-Castaño, Inmaculada, Casas, Rosa, Muñoz-Garach, Araceli, Santos-Lozano, J. M., Trias, Ferrán, Gallardo-Alfaro, Laura, Ruiz-Canela, Miguel, Barragán, Rocío, Goday, Alberto, Galmés-Panadés, Aina M., González-Botella, Andrés, Vaquero-Luna, Jessica, Toledo, Estefania, Castañer, Olga, Salas-Salvadó, Jordi, Instituto de Salud Carlos III, European Commission, European Research Council, Fundación la Caixa, Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Fundació Institut d'Investigació Sanitària Illes Balears, Papandreou, Christopher, Díaz-López, Andrés, Babio, Nancy, Martínez-García, Miguel Ángel, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Becerra-Tomás, Nerea, Martínez-Lacruz, Raúl, Schröder, Helmut, Konieczna, Jadwiga, García-de-la-Hera, Manoli, Moreno-Rodríguez, Anai, Barón-López, Javier, Pérez-Farinós, Napoleón, Abete, Itziar, Bautista-Castaño, Inmaculada, Casas, Rosa, Muñoz-Garach, Araceli, Santos-Lozano, J. M., Trias, Ferrán, Gallardo-Alfaro, Laura, Ruiz-Canela, Miguel, Barragán, Rocío, Goday, Alberto, Galmés-Panadés, Aina M., González-Botella, Andrés, Vaquero-Luna, Jessica, Toledo, Estefania, Castañer, Olga, and Salas-Salvadó, Jordi

Abstract

Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals from the Mediterranean region. A cross-sectional analysis of baseline data from 2190 elderly participants with overweight/obesity and metabolic syndrome, in the PREDIMED-Plus trial, was carried out. Accelerometer-derived napping was measured. Prevalence ratios (PR) and 95% confidence intervals (CI) for T2D were obtained using multivariable-adjusted Cox regression with constant time. Linear regression models were fitted to examine associations of napping with body mass index (BMI) and waist circumference (WC). Participants napping ≥90 min had a higher prevalence of T2D (PR 1.37 (1.06, 1.78)) compared with those napping 5 to <30 min per day. Significant positive associations with BMI and WC were found in those participants napping ≥30 min as compared to those napping 5 to <30 min per day. The findings of this study suggest that longer daytime napping is associated with higher T2D prevalence and greater adiposity measures in an elderly Spanish population at high cardiovascular risk.

Published
2019

130. Association between fatty acids of blood cell membranes and incidence of coronary heart disease

Author

Fundació La Marató de TV3, Generalitat de Catalunya, Instituto de Salud Carlos III, European Commission, Universidad Rovira i Virgili, Papandreou, Christopher, Sala-Vila, Aleix, Galié, Serena, Muralidharan, Jananee, Estruch, Ramón, Fitó, Montserrat, Razquin, Cristina, Corella, Dolores, Ros, Emilio, Timiraos, Juan, Lapetra, José, Serra-Majem, Lluis, Carlos, Silvia, Castañer, Olga, Asensio, Eva M., Salas-Salvadó, Jordi, Bulló, Mònica, Fundació La Marató de TV3, Generalitat de Catalunya, Instituto de Salud Carlos III, European Commission, Universidad Rovira i Virgili, Papandreou, Christopher, Sala-Vila, Aleix, Galié, Serena, Muralidharan, Jananee, Estruch, Ramón, Fitó, Montserrat, Razquin, Cristina, Corella, Dolores, Ros, Emilio, Timiraos, Juan, Lapetra, José, Serra-Majem, Lluis, Carlos, Silvia, Castañer, Olga, Asensio, Eva M., Salas-Salvadó, Jordi, and Bulló, Mònica

Abstract

[Objective]: To examine the associations between baseline levels of fatty acids in blood cell membranes and their 1-year changes with the incidence of coronary heart disease (CHD) in older adults at high cardiovascular disease risk. [Approach and Results]: This is a case-control study nested in the PREDIMED trial (Prevención con Dieta Mediterránea), with 136 CHD cases and 272 controls (matched on age, sex, body mass index, intervention group, and time of permanence in the study to the time event). We used gas chromatography to measure the proportion of 22 fatty acids in blood cell membranes at baseline and after 1 year. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% CIs. After adjustment for classical CHD risk factors and multiple testing, 1 SD increase in baseline levels of C22:0, C24:0 and the sum of individual very long chain saturated fatty acids was associated with 56% (OR, 0.44 [95% CI, 0.28–0.69]), 59% (OR, 0.41 [95% CI, 0.25–0.65]), and 55% (OR, 0.45 [95% CI, 0.29–0.70]) a decreased odds of developing CHD, respectively. Baseline C20:1n9 was associated with higher odds of CHD (OR, 1.58 [95% CI, 1.25–2.00]). [Conclusions]: Higher levels of C22:0 and C24:0 were associated with a lower CHD incidence, whereas higher levels of C20:1n9 were associated with a higher risk. This study adds to the growing body of evidence suggesting potential differences in the cardiovascular disease effects of different types of circulating saturated fatty acids.

Published
2019

131. Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk

Author

Juanola-Falgarona Martí, Salas-Salvadó Jordi, Estruch Ramon, Portillo Maria P, Casas Rosa, Miranda Jonatan, Martínez-González Miguel A, and Bulló Mònica

Subjects
Vitamin K, Inflammation, Insulin resistance, Diabetes, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Vitamin K has been related to glucose metabolism, insulin sensitivity and diabetes. Because inflammation underlies all these metabolic conditions, it is plausible that the potential role of vitamin K in glucose metabolism occurs through the modulation of cytokines and related molecules. The purpose of the study was to assess the associations between dietary intake of vitamin K and peripheral adipokines and other metabolic risk markers related to insulin resistance and type 2 diabetes mellitus. Methods Cross-sectional and longitudinal assessments of these associations in 510 elderly participants recruited in the PREDIMED centers of Reus and Barcelona (Spain). We determined 1-year changes in dietary phylloquinone intake estimated by food frequency questionnaires, serum inflammatory cytokines and other metabolic risk markers. Results In the cross-sectional analysis at baseline no significant associations were found between dietary phylloquinone intake and the rest of metabolic risk markers evaluated, with exception of a negative association with plasminogen activator inhibitor-1. After 1-year of follow-up, subjects in the upper tertile of changes in dietary phylloquinone intake showed a greater reduction in ghrelin (−15.0%), glucose-dependent insulinotropic peptide (−12.9%), glucagon-like peptide-1 (−17.6%), IL-6 (−27.9%), leptin (−10.3%), TNF (−26.9%) and visfatin (−24.9%) plasma concentrations than those in the lowest tertile (all p Conclusion These results show that dietary phylloquinone intake is associated with an improvement of cytokines and other markers related to insulin resistance and diabetes, thus extending the potential protection by dietary phylloquinone on chronic inflammatory diseases. Trial registration http://www.controlled-trials.com as ISRCTN35739639

Published
2013
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132. Pistachios for Health

Author

Hernández-Alonso, Pablo, Bulló, Mònica, and Salas-Salvadó, Jordi

Subjects
digestive, oral, and skin physiology, food and beverages, Food and Nutrition Science
Abstract

Human beings have known about pistachio nuts since 6000 bc. Since then, pistachios have been systematically incorporated into the diet of various cultures. They are nutrient-dense nuts with a healthy nutritional profile that contains fiber, unsaturated fatty acids and antioxidant compounds.

Published
2016

134. Plasma vitamin D and parathormone are associated with obesity and atherogenic dyslipidemia: a cross-sectional study

Author

Guasch Alba, Bulló Mònica, Rabassa Antoni, Bonada Anna, Del Castillo Daniel, Sabench Fàtima, and Salas-Salvadó Jordi

Subjects
Obesity, Metabolic syndrome, Vitamin D, Parathormone, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Low concentrations of plasma vitamin D (25(OH)D) have been associated with the development of metabolic syndrome (MetS), obesity, diabetes and cardiovascular disease. The objective of this study was to quantify the associations between 25(OH)D and parathormone (PTH) plasma levels and obesity, the presence of MetS, diabetes or atherogenic dyslipidemia (AD) in a large sample of individuals with different degrees of adiposity. Methods Retrospective study of all patients who had attended the obesity clinics in a Spanish hospital between 2009 and 2011, and whose concentrations of PTH, 25(OH)D, calcium and alkaline phosphatase had been determined (n=316, 75.9% women). Individuals were categorized by degree of adiposity, presence of MetS, and other comorbidities. Results PTH increased but 25(OH)D and calcium decreased with increasing adiposity. The prevalence of 25(OH)D deficiency or insufficiency increased with obesity (2, and 26% when >50). The prevalence of hyperparathyroidism increased from 12% in non-obese to 47.5% in morbidly obese individuals with BMI>50 kg/m2. Low plasma 25(OH)D and high PTH concentrations were associated with an increased risk of MetS and AD. These associations disappeared, except in the case of AD for 25(OH)D when adjusting for BMI. Regression analysis revealed that BMI and age or seasonality were independent predictors of PTH and 25(OH)D levels, respectively. Conclusions BMI was the variable most strongly associated with plasma 25(OH)D and PTH concentrations in our study. Low 25(OH)D and high PTH concentrations were not independently associated with an increased risk of MetS, or diabetes. Our data support a possible contribution of plasma 25(OH)D to the pathogenesis of hypertriglyceridemia and AD through inflammation.

Published
2012
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135. Plasma Metabolites Associated with Frequent Red Wine Consumption: A Metabolomics Approach within the PREDIMED Study

Author

Hernández‐Alonso, Pablo, primary, Papandreou, Christopher, additional, Bulló, Mònica, additional, Ruiz‐Canela, Miguel, additional, Dennis, Courtney, additional, Deik, Amy, additional, Wang, Dong D., additional, Guasch‐Ferré, Marta, additional, Yu, Edward, additional, Toledo, Estefanía, additional, Razquin, Cristina, additional, Corella, Dolores, additional, Estruch, Ramon, additional, Ros, Emilio, additional, Fitó, Montserrat, additional, Arós, Fernando, additional, Fiol, Miquel, additional, Serra‐Majem, Lluís, additional, Liang, Liming, additional, Clish, Clary B., additional, Martínez‐González, Miguel A, additional, Hu, Frank B, additional, and Salas‐Salvadó, Jordi, additional

Published
2019
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136. Predictors of successful weight loss with relative maintenance of fat-free mass in individuals with overweight and obesity on an 8-week low-energy diet

Author

Hansen, Thea Toft, primary, Hjorth, Mads Fiil, additional, Sandby, Karoline, additional, Andersen, Sarah Vold, additional, Astrup, Arne, additional, Ritz, Christian, additional, Bulló, Mònica, additional, Camacho-Barcía, Maria Lucia, additional, García-Gavilán, Jesús Francisco, additional, Salas-Salvadó, Jordi, additional, Harrold, Joanne A., additional, Halford, Jason C.G., additional, and Sjödin, Anders, additional

Published
2019
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138. Pistachio consumption modulates DNA oxidation and genes related to telomere maintenance: a crossover randomized clinical trial

Author

Canudas, Silvia, primary, Hernández-Alonso, Pablo, additional, Galié, Serena, additional, Muralidharan, Jananee, additional, Morell-Azanza, Lydia, additional, Zalba, Guillermo, additional, García-Gavilán, Jesús, additional, Martí, Amelia, additional, Salas-Salvadó, Jordi, additional, and Bulló, Mònica, additional

Published
2019
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139. Plasma Metabolites Associated with Coffee Consumption: A Metabolomic Approach within the PREDIMED Study

Author

Papandreou, Christopher, primary, Hernández-Alonso, Pablo, additional, Bulló, Mònica, additional, Ruiz-Canela, Miguel, additional, Yu, Edward, additional, Guasch-Ferré, Marta, additional, Toledo, Estefanía, additional, Dennis, Courtney, additional, Deik, Amy, additional, Clish, Clary, additional, Razquin, Cristina, additional, Corella, Dolores, additional, Estruch, Ramon, additional, Ros, Emilio, additional, Fitó, Montserrat, additional, Arós, Fernando, additional, Fiol, Miquel, additional, Lapetra, José, additional, Ruano, Cristina, additional, Liang, Liming, additional, Martínez-González, Miguel A., additional, Hu, Frank B., additional, and Salas-Salvadó, Jordi, additional

Published
2019
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140. Plasma metabolites predict both insulin resistance and incident type 2 diabetes: a metabolomics approach within the Prevención con Dieta Mediterránea (PREDIMED) study

Author

Papandreou, Christopher, primary, Bulló, Mònica, additional, Ruiz-Canela, Miguel, additional, Dennis, Courtney, additional, Deik, Amy, additional, Wang, Daniel, additional, Guasch-Ferré, Marta, additional, Yu, Edward, additional, Razquin, Cristina, additional, Corella, Dolores, additional, Estruch, Ramon, additional, Ros, Emilio, additional, Fitó, Montserrat, additional, Fiol, Miquel, additional, Liang, Liming, additional, Hernández-Alonso, Pablo, additional, Clish, Clary B, additional, Martínez-González, Miguel A, additional, Hu, Frank B, additional, and Salas-Salvadó, Jordi, additional

Published
2019
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141. Legume consumption and risk of all-cause, cardiovascular, and cancer mortality in the PREDIMED study

Author

Papandreou, Christopher, primary, Becerra-Tomás, Nerea, additional, Bulló, Mònica, additional, Martínez-González, Miguel Ángel, additional, Corella, Dolores, additional, Estruch, Ramon, additional, Ros, Emilio, additional, Arós, Fernando, additional, Schroder, Helmut, additional, Fitó, Montserrat, additional, Serra-Majem, Lluís, additional, Lapetra, José, additional, Fiol, Miquel, additional, Ruiz-Canela, Miguel, additional, Sorli, Jose V., additional, and Salas-Salvadó, Jordi, additional

Published
2019
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142. Is reduction in appetite beneficial for body weight management in the context of overweight and obesity? Yes, according to the SATIN (Satiety Innovation) study

Author

Hansen, Thea Toft, primary, Mead, Bethan R., additional, García-Gavilán, Jesús Francisco, additional, Korndal, Sanne Kellebjerg, additional, Harrold, Joanne A., additional, Camacho-Barcía, Lucia, additional, Ritz, Christian, additional, Christiansen, Paul, additional, Salas-Salvadó, Jordi, additional, Hjorth, Mads Fiil, additional, Blundell, John, additional, Bulló, Mònica, additional, Halford, Jason C. G., additional, and Sjödin, Anders, additional

Published
2019
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143. Plasma Acylcarnitines and Risk of Type 2 Diabetes in a Mediterranean Population at High Cardiovascular Risk

Author

Guasch-Ferré, Marta, primary, Ruiz-Canela, Miguel, additional, Li, Jun, additional, Zheng, Yan, additional, Bulló, Mònica, additional, Wang, Dong D, additional, Toledo, Estefanía, additional, Clish, Clary, additional, Corella, Dolores, additional, Estruch, Ramon, additional, Ros, Emilio, additional, Fitó, Montserrat, additional, Arós, Fernando, additional, Fiol, Miquel, additional, Lapetra, José, additional, Serra-Majem, Lluís, additional, Liang, Liming, additional, Papandreou, Christopher, additional, Dennis, Courtney, additional, Martínez-González, Miguel A, additional, Hu, Frank B, additional, and Salas-Salvadó, Jordi, additional

Published
2018
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145. Moderate red wine consumption is associated with a lower prevalence of the metabolic syndrome in the PREDIMED population

Author

Tresserra-Rimbau, Anna, Medina-Remón, Alexander, Lamuela-Raventós, Rosa M., Bulló, Mònica, Salas-Salvadó, Jordi, Corella, Dolores, Fitó Colomer, Montserrat, Gea, Alfredo, Gómez-Gracia, Enrique, Lapetra, José, Arós, Fernando, Fiol, Miquel, Ros, Emilio, Serra-Majem, Luis, Pinto, Xavier, Muñoz, Miguel Ángel, Estruch, Ramón, PREDIMED investigators, and Universitat de Barcelona

Subjects
Male, Gerontology, Aging, Síndrome metabòlica, medicine.medical_specialty, Waist, Alcohol Drinking, Population, Medicine (miscellaneous), Wine, Diet, Mediterranean, Lower risk, Plant Epidermis, Cohort Studies, Sex Factors, Risk Factors, Diabetes mellitus, Internal medicine, Prevalence, medicine, Humans, Vitis, Vi, education, Abdominal obesity, Aged, Metabolic Syndrome, education.field_of_study, Nutrition and Dietetics, medicine.diagnostic_test, business.industry, Confounding, Pigments, Biological, Middle Aged, medicine.disease, Metabolic syndrome, Cross-Sectional Studies, Cardiovascular Diseases, Spain, Drinking of alcoholic beverages, Fruit, Vi -- Anàlisi, Consum d'alcohol, Female, medicine.symptom, Alcohol, Lipid profile, business
Abstract

Previous studies on the association between alcohol intake and the development of the metabolic syndrome (MetS) have yielded inconsistent results. Besides, few studies have analysed the effects of red wine (RW) consumption on the prevalence of the MetS and its components. As moderate RW drinkers have a better lipid profile and lower incidence rates of diabetes, hypertension and abdominal obesity, all components of the MetS, it was hypothesised that moderate RW consumption could be associated with a lower prevalence of the MetS. In the present cross-sectional study of 5801 elderly participants at a high cardiovascular risk included in the PREDIMED (Prevención con Dieta Mediterránea) study, 3897 fulfilled the criteria of the MetS at baseline. RW intake was recorded using a validated 137-item FFQ. Multiple logistic regression analysis was carried out to estimate the association between RW intake and the prevalence of the MetS. Compared with non-drinkers, moderate RW drinkers (≥ 1 drink/d) were found to have a reduced risk of prevalent MetS (OR 0.56, 95 % CI 0.45, 0.68; P < 0.001), a lower risk of having an abnormal waist circumference (OR 0.59, 95 % CI 0.46, 0.77; P < 0.001), low HDL-cholesterol concentrations (OR 0.42, 95 % CI 0.32, 0.53; P < 0.001), high blood pressure (OR 0.28, 95 % CI 0.17, 0.45; P < 0.001) and high fasting plasma glucose concentrations (OR 0.67, 95 % CI 0.54, 0.82; P < 0.001) after adjusting for several confounders. This association was found to be stronger in female participants, in participants aged < 70 years and in participants who were former or current smokers. No significant association was found between RW intake (≥ 1 drink/d) and TAG concentrations. In conclusion, moderate RW consumption is associated with a lower prevalence of the MetS in an elderly Mediterranean population at a high cardiovascular risk. Publication of these papers was supported by unrestricted educational grants from Federación Española de Sociedades de Nutrición, Alimentación y Dietética (FESNAD), International Nut and Dried Fruit Council (INC), International Union of Nutritional Sciences (IUNS), Fundación Iberoamericana de Nutrición (FINUT), Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Centro Interuniversitario di Ricerca sulle Culture Alimentari Mediterranee (Ciiscam)

Published
2015

146. Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial

Author

Instituto de Salud Carlos III, European Research Council, Junta de Andalucía, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, European Commission, Schröder, Helmut, Cárdenas-Fuentes, Gabriela, Martínez-González, Miguel Ángel, Corella, Dolores, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Tinahones, Francisco J., Miranda, José L., Estruch, Ramón, Bueno-Cavanillas, Aurora, Arós, Fernando, Marcos, Ascensión, Tur, Josep A., Wärnberg, Julia, Serra-Majem, Lluis, Martín, Vicente, Vázquez, Clotilde, Lapetra, José, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Gaforio, José Juan, Matía-Martín, Pilar, Ros, Emilio, Castañer, Olga, Lassale, Camille, Ruiz-Canela, Miguel, Asensio, Eva M., Basora, Josep, Torres-Collado, Laura, Garcia-Rios, Antonio, Abete, Itziar, Toledo, Estefania, Buil-Cosiales, Pilar, Bulló, Mònica, Goday, Albert, Fitó, Montserrat, Salas-Salvadó, Jordi, Instituto de Salud Carlos III, European Research Council, Junta de Andalucía, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, European Commission, Schröder, Helmut, Cárdenas-Fuentes, Gabriela, Martínez-González, Miguel Ángel, Corella, Dolores, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Tinahones, Francisco J., Miranda, José L., Estruch, Ramón, Bueno-Cavanillas, Aurora, Arós, Fernando, Marcos, Ascensión, Tur, Josep A., Wärnberg, Julia, Serra-Majem, Lluis, Martín, Vicente, Vázquez, Clotilde, Lapetra, José, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Gaforio, José Juan, Matía-Martín, Pilar, Ros, Emilio, Castañer, Olga, Lassale, Camille, Ruiz-Canela, Miguel, Asensio, Eva M., Basora, Josep, Torres-Collado, Laura, Garcia-Rios, Antonio, Abete, Itziar, Toledo, Estefania, Buil-Cosiales, Pilar, Bulló, Mònica, Goday, Albert, Fitó, Montserrat, and Salas-Salvadó, Jordi

Abstract

[Background] The development and implementation of effective physical activity (PA) intervention programs is challenging, particularly in older adults. After the first year of the intervention program used in the ongoing PREvención con DIeta MEDiterránea (PREDIMED)-Plus trial, we assessed the initial effectiveness of the PA component., [Methods] PREDIMED-Plus is an ongoing randomized clinical trial including 6874 participants randomized to an intensive weight-loss lifestyle intervention based on an energy-restricted Mediterranean diet (MedDiet), physical activity promotion and behavioral support and to a control group using MedDiet recommendations but without calorie restriction or PA advice. Body mass index (BMI) and waist circumference (WC) are measured by standard clinical protocols. Duration and intensity of PA is self-reported using the validated REGICOR Short Physical Activity Questionnaire. The primary endpoint of the PREDIMED-Plus trial is a combined cardiovascular outcome: myocardial infarction (acute coronary syndromes with positive troponin test), stroke, or cardiovascular mortality. The present study involved secondary analysis of PA data (n = 6059; mean age 65 ± 4.9 years) with one-year changes in total, light, and moderate-to-vigorous PA within and between intervention groups as the outcome. Generalized estimating equation models were fitted to evaluate time trends of PA, BMI, and WC within groups and differences between intervention and control groups., [Results] After 12 months, average daily MVPA increased by 27.2 (95%CI 5.7;48.7) METs-min/day and 123.1 (95%CI 109.7–136.6) METs-min/day in the control and intervention groups, respectively. Total-PA, light-PA, and MVPA increased significantly (p < 0.01) in both groups. A significant (p < 0.001) time*intervention group interaction was found for Total-PA and MVPA, meaning the PA trajectory over time differed between the intervention and control groups. Age, sex, education level, and BMI did not moderate the effectiveness of the PA intervention. BMI and WC decreased significantly with increasing MVPA, compared with participants who reported no changes in MVPA., [Conclusion] After one year of follow-up, the PREDIMED-Plus PA intervention has been effective in increasing daily PA in older adults., [Trial registration] Retrospectively registered at the International Standard Randomized Controlled Trial (http://www.isrctn.com/ISRCTN89898870), registration date: 24 July 2014.

Published
2018

147. Sperm DNA methylation changes after short‐term nut supplementation in healthy men consuming a Western‐style diet.

Author

Salas‐Huetos, Albert, James, Emma R., Salas‐Salvadó, Jordi, Bulló, Mònica, Aston, Kenneth I., Carrell, Douglas T., and Jenkins, Timothy G.

Subjects
WESTERN diet, DNA methylation, SPERMATOZOA, NUTS, SEMEN analysis
Abstract

Background: Many environmental and lifestyle factors have been implicated in the decline of sperm quality, with diet being one of the most plausible factors identified in recent years. Moreover, several studies have reported a close association between the alteration of specific sperm DNA methylation signatures and semen quality. Objectives: To evaluate the effect of tree nut consumption on sperm DNA methylation patterns in healthy individuals reporting eating a Western‐style diet. Material and methods: This is a post hoc analysis conducted in a subset of participants (healthy, non‐smoking, and young) from the FERTINUTS 14‐wk randomized‐controlled, parallel trial, recruited between December 2015 and February 2017. The participants included in the current study (n = 72) were randomly selected in a proportion 2:1 from the original FERTINUTS trial between the 98 participants that completed the entire dietary intervention (nut group, n = 48; control group, n = 24). Sperm DNA methylation patterns were examined at baseline and after 14 weeks in 48 individuals consuming 60 g/d of mixed nuts (nut group) and in 24 individuals following the usual Western‐style diet avoiding consumption of nuts (control group). Results: Over the course of the trial, no significant changes in global methylation were observed between groups. However, in the nut group, we identified 36 genomic regions that were significantly differentially methylated between the baseline and the end of the trial and 97.2% of the regions displayed hypermethylation. We identified no such change in the control group over the same period of time. We also utilized the recently developed germ line age calculator to determine if nut consumption resulted in alterations to the epigenetic age of cells and no significant differences were found. Discussion and conclusion: Adding nuts to a regular Western‐style diet subtly impacts sperm DNA methylation in specific regions, demonstrating that there are some sperm epigenome regions that could respond to diet. [ABSTRACT FROM AUTHOR]

Published
2021
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148. Higher dietary glycemic index and glycemic load values increase the risk of osteoporotic fracture in the PREvención con DIeta MEDiterránea (PREDIMED)-Reus trial

Author

García-Gavilán, Jesús Francisco, primary, Bulló, Mònica, additional, Camacho-Barcia, Lucia, additional, Rosique-Esteban, Nuria, additional, Hernández-Alonso, Pablo, additional, Basora, Josep, additional, Martínez-González, Miguel Angel, additional, Estruch, Ramón, additional, Fitó, Montserrat, additional, and Salas-Salvadó, Jordi, additional

Published
2018
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