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103. International consensus report on the investigation and management of primary immune thrombocytopenia

Author

Provan, Drew, Stasi, Roberto, Newland, Adrian C., Blanchette, Victor S., Bolton-Maggs, Paula, Bussel, James B., Chong, Beng H., Cines, Douglas B., Gernsheimer, Terry B., Godeau, Bertrand, Grainger, John, Greer, Ian, Hunt, Beverley J., Imbach, Paul A., Lyons, Gordon, McMillan, Robert, Rodeghiero, Francesco, Sanz, Miguel A., Tarantino, Michael, Watson, Shirley, Young, Joan, and Kuter, David J.

Published
2010
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104. A Review of Romiplostim Mechanism of Action and Clinical Applicability

Author

Bussel,James B, Soff,Gerald, Balduzzi,Adriana, Cooper,Nichola, Lawrence,Tatiana, and Semple,John W

Subjects
Drug Design, Development and Therapy, hemic and lymphatic diseases
Abstract

James B Bussel,1 Gerald Soff,2 Adriana Balduzzi,3 Nichola Cooper,4 Tatiana Lawrence,5 John W Semple6,7 1Department of Pediatrics, Division of Hematology, Weill Cornell Medicine, New York, NY, USA; 2Department of Medicine, Hematology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; 3Clinica Pediatrica Università degli Studi di Milano Bicocca, Ospedale San Gerardo, Monza, Italy; 4Hammersmith Hospital, Imperial College, London, UK; 5Amgen Inc., Thousand Oaks, CA, USA; 6Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden; 7Department of Pharmacology, University of Toronto, Toronto, ON, CanadaCorrespondence: James B BusselDepartment of Pediatrics, Division of Hematology, Weill Cornell Medicine, 525 East 68th St, P695, New York, NY, 10065, USATel +1 917 291 5091Fax +1 212 746 8609Email jbussel@med.cornell.eduAbstract: Thrombocytopenia results from a variety of conditions, including radiation, chemotherapy, autoimmune disease, bone marrow disorders, pathologic conditions associated with surgical procedures, hematopoietic stem cell transplant (HSCT), and hematologic disorders associated with severe aplastic anemia. Immune thrombocytopenia (ITP) is caused by immune reactions that accelerate destruction and reduce production of platelets. Thrombopoietin (TPO) is a critical component of platelet production pathways, and TPO receptor agonists (TPO-RAs) are important for the management of ITP by increasing platelet production and reducing the need for other treatments. Romiplostim is a TPO-RA approved for use in patients with ITP in the United States, European Union, Australia, and several countries in Africa and Asia, as well as for use in patients with refractory aplastic anemia in Japan and Korea. Romiplostim binds to and activates the TPO receptor on megakaryocyte precursors, thus promoting cell proliferation and viability, resulting in increased platelet production. Through this mechanism, romiplostim reduces the need for other treatments and decreases bleeding events in patients with thrombocytopenia. In addition to its efficacy in ITP, studies have shown that romiplostim is effective in improving platelet counts in various settings, thereby highlighting the versatility of romiplostim. The efficacy of romiplostim in such disorders is currently under investigation. Here, we review the structure, mechanism, pharmacokinetics, and pharmacodynamics of romiplostim. We also summarize the clinical evidence supporting its use in ITP and other disorders that involve thrombocytopenia, including chemotherapy-induced thrombocytopenia, aplastic anemia, acute radiation syndrome, perisurgical thrombocytopenia, post-HSCT thrombocytopenia, and liver disease.Keywords: immune thrombocytopenia, pharmacokinetics, pharmacodynamics, structure, thrombopoietin receptor agonist

Published
2021

110. Longitudinal study of 2 patients with cyclic thrombocytopenia, STAT3and MPLmutations

Author

Zhang, Haiyu, Chien, May, Hou, Yu, Shomali, William, Brar, Rondeep S., Ho, Chandler, Han, Panpan, Xu, Danfei, Zhang, Bing M., Guo, Xiangqian, Tolentino, Lorna L., Wu, Nancy C., Tsai, Albert G., Jin, Jing, Witteles, Wesley H., Chen, Zhenping, Abidi, Parveen, Jangam, Diwash, Krieger, Madison S., Craig, Morgan, Bussel, James B., Gotlib, Jason R., and Zehnder, James L.

Abstract

•Both patients showed sequential exaggerated TPO, platelet gene, and platelet count cycling, as well as trilineage gene fluctuations.•Both had somatic GOF STAT3mutations and clonal T cells; 1 had a novel germline LOF MPLmutation correlating with cycling parameters.

Published
2023
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114. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group

Author

Rodeghiero, Francesco, Stasi, Roberto, Gernsheimer, Terry, Michel, Marc, Provan, Drew, Arnold, Donald M., Bussel, James B., Cines, Douglas B., Chong, Beng H., Cooper, Nichola, Godeau, Bertrand, Lechner, Klaus, Mazzucconi, Maria Gabriella, McMillan, Robert, Sanz, Miguel A., Imbach, Paul, Blanchette, Victor, Kühne, Thomas, Ruggeri, Marco, and George, James N.

Published
2009
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119. sj-pdf-1-tah-10.1177_20406207211010875 – Supplemental material for Assessment of thrombotic risk during long-term treatment of immune thrombocytopenia with fostamatinib

Author

Cooper, Nichola, Altomare, Ivy, Thomas, Mark R., Nicolson, Phillip L. R., Watson, Steve P., Markovtsov, Vadim, Todd, Leslie K., Masuda, Esteban, and Bussel, James B.

Subjects
FOS: Clinical medicine, Cardiology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-tah-10.1177_20406207211010875 for Assessment of thrombotic risk during long-term treatment of immune thrombocytopenia with fostamatinib by Nichola Cooper, Ivy Altomare, Mark R. Thomas, Phillip L. R. Nicolson, Steve P. Watson, Vadim Markovtsov, Leslie K. Todd, Esteban Masuda and James B. Bussel in Therapeutic Advances in Hematology

Published
2021
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123. List of Contributors

Author

Agmon-Levin, Nancy, primary, Ahmed, S. Sohail, additional, Ali, Youssif M., additional, Aringer, Martin, additional, Bach, Jean-François, additional, Barker, Jennifer, additional, Barker, Robert N., additional, Baxter, Alan G., additional, Betterle, Corrado, additional, Birlea, Stanca A., additional, Björkström, Niklas K., additional, Blair, Paul A., additional, Bobik, Alex, additional, Borazan, Nabeel H., additional, Bosch, Xavier, additional, Brodsky, Robert A., additional, Bryceson, Yenan T., additional, Burkett, Patrick R., additional, Bussel, James B., additional, Butzkueven, Helmut, additional, Caricchio, Roberto, additional, Casciola-Rosen, Livia, additional, Caturegli, Patrizio, additional, Chatenoud, Lucienne, additional, Cohen, Philip L., additional, Coppieters, Ken, additional, Crome, Sarah Q., additional, Crystal, Ronald G., additional, Culton, Donna A., additional, Dalal, Monica D., additional, David, Chella S., additional, Davidson, Anne, additional, Delli, Ahmed J., additional, Delves, Peter J., additional, Denmark, Vera Kandror, additional, Diamond, Betty, additional, Diaz, Luis A., additional, Eaton, John E., additional, Eisenbarth, George S., additional, Falk, Ronald J., additional, Field, Judith, additional, Fleisher, Thomas A., additional, Fragoulis, George E., additional, Fritzler, Marvin J., additional, Furst, Daniel E., additional, Gallucci, Stefania, additional, Gelbman, Brian, additional, Eric Gershwin, M., additional, Getts, Daniel R., additional, Getts, Meghann Teague, additional, Gianani, Roberto, additional, Gleeson, Paul A., additional, Goding, James W., additional, Gordon, Siamon, additional, Goronzy, Jörg J., additional, Greer, Judith M., additional, Gruson, Berengere, additional, Guilherme, L., additional, Gutenberg, Angelika, additional, Hafler, David A., additional, Hahn, Bevra H., additional, Hamano, Hideaki, additional, Hamilton, Sara R., additional, Harrison, Leonard C., additional, Hernandez, Amanda L., additional, Husebye, Eystein, additional, Charles Jennette, J., additional, Jones, Richard J., additional, Jordan, Margaret A., additional, Kalil, J., additional, Königs, Christoph, additional, Kawa, Shigeyuki, additional, Kaya, Ziya, additional, King, Jennifer K., additional, King, Nicholas J.C., additional, Kiyosawa, Kendo, additional, Kronenberg, Mitchell, additional, Kuchroo, Vijay K., additional, Kyaw, Tin, additional, Lünemann, Jan, additional, Lahita, Robert G., additional, Lalezari, Parviz, additional, Lambert, Paul-Henri, additional, Lancaster, Eric, additional, Laurence, Arian, additional, Lee, Youjin, additional, Lenardo, Michael, additional, Lernmark, Åke, additional, Levinson, Arnold I., additional, Lindor, Keith D., additional, Liu, Zhi, additional, Ljunggren, Hans-Gustaf, additional, Lunardi, Claudio, additional, Lundin, Knut E.A., additional, Lunn, Michael P.T., additional, Lupi, Isabella, additional, Lustig, Livia, additional, Münz, Christian, additional, Mackay, Charles R., additional, Mackay, Ian R., additional, Malattia, Clara, additional, Mangalam, Ashutosh, additional, Martini, Alberto, additional, Mauri, Claudia, additional, Mavragani, Clio P., additional, Mayer, Lloyd, additional, McCombe, Pamela A., additional, Melchers, Fritz, additional, Mieli-Vergani, Giorgina, additional, Miller, Frederick W., additional, Miller, Stephen D., additional, Mizui, Masayuki, additional, Mjösberg, Jenny, additional, Moutsopoulos, Haralampos M., additional, Norris, David A., additional, Nussenblatt, Robert B., additional, O’Connor, Kevin C., additional, Ohashi, Pamela S., additional, O’Keeffe, Meredith, additional, Oliveira, Joao Bosco, additional, Oppenheim, Joost J., additional, Perez-Arroyo, Alicia, additional, Peters, Anneli, additional, Peterson, Pärt, additional, Plüddemann, Annette, additional, Posner, Jerome B., additional, Preston, Gloria A., additional, Puccetti, Antonio, additional, Radford, Kristen, additional, Ramos-Casals, Manuel, additional, Rao, V. Koneti, additional, Rauschkolb, Paula K., additional, Reddy, Venkat, additional, Redlich, Kurt, additional, Rival, Claudia, additional, Rose, Noel R., additional, Rosen, Antony, additional, Schrader, John W., additional, Schwaeble, Wilhelm J., additional, Selmi, Carlo, additional, Nida Sen, H., additional, Serota, Marc, additional, Sheikh, Kazim A., additional, Shoenfeld, Yehuda, additional, Shortman, Ken, additional, Sieper, Joachim, additional, Silverstein, Arthur M., additional, Sim, Robert B., additional, Simon, Anna, additional, Smolen, Josef S., additional, Sollid, Ludvig M., additional, Stoffels, Monique, additional, Su, Helen, additional, Syrbe, Uta, additional, Talwalkar, Jayant A., additional, Taneja, Veena, additional, Tincani, Angela, additional, Tipping, Peter, additional, Toh, Ban-Hock, additional, Tsokos, George C., additional, Tu, Eric, additional, Tung, Kenneth S.K., additional, van Driel, Ian R., additional, Vergani, Diego, additional, Vickers, Mark A., additional, Viegas, Stuart, additional, Vincent, Angela, additional, von Andrian, Ulrich H., additional, Herrath, Matthias von, additional, Weetman, Anthony P., additional, Wentworth, John M., additional, Weyand, Cornelia M., additional, Wingender, Gerhard, additional, Zanchetta, Renato, additional, and Zouali, Moncef, additional

Published
2014
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126. Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients

Author

Di Buduo, Christian A, primary, Laurent, Pierre-Alexandre, additional, Zaninetti, Carlo, additional, Lordier, Larissa, additional, Soprano, Paolo M, additional, Ntai, Aikaterini, additional, Barozzi, Serena, additional, La Spada, Alberto, additional, Biunno, Ida, additional, Raslova, Hana, additional, Bussel, James B, additional, Kaplan, David L, additional, Balduini, Carlo L, additional, Pecci, Alessandro, additional, and Balduini, Alessandra, additional

Published
2021
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128. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial

Author

Kuter, David J, Bussel, James B, Lyons, Roger M, Pullarkat, Vinod, Gernsheimer, Terry B, Senecal, Francis M, Aledort, Louis M, George, James N, Kessler, Craig M, Sanz, Miguel A, Liebman, Howard A, Slovick, Frank T, de Wolf, J Th M, Bourgeois, Emmanuelle, Guthrie, Troy H, Jr, Newland, Adrian, Wasser, Jeffrey S, Hamburg, Solomon I, Grande, Carlos, Lefrère, François, Lichtin, Alan Eli, Tarantino, Michael D, Terebelo, Howard R, Viallard, Jean-François, Cuevas, Francis J, Go, Ronald S, Henry, David H, Redner, Robert L, Rice, Lawrence, Schipperus, Martin R, Guo, D Matthew, and Nichol, Janet L

Published
2008
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134. Quality of life is an important indication for second‐line treatment in children with immune thrombocytopenia

Author

Shimano, Kristin A., primary, Neunert, Cindy, additional, Bussel, James B., additional, Klaassen, Robert J., additional, Bhat, Rukhmi, additional, Pastore, Yves D., additional, Lambert, Michele P., additional, Bennett, Carolyn M., additional, Despotovic, Jenny M., additional, Forbes, Peter, additional, and Grace, Rachael F., additional

Published
2021
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135. Thrombocytopenia following Pfizer and Moderna SARS‐CoV ‐2 vaccination

Author

Lee, Eun‐Ju, primary, Cines, Douglas B., additional, Gernsheimer, Terry, additional, Kessler, Craig, additional, Michel, Marc, additional, Tarantino, Michael D., additional, Semple, John W., additional, Arnold, Donald M., additional, Godeau, Bertrand, additional, Lambert, Michele P., additional, and Bussel, James B., additional

Published
2021
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136. Author response: Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients

Author

Di Buduo, Christian A, primary, Laurent, Pierre-Alexandre, additional, Zaninetti, Carlo, additional, Lordier, Larissa, additional, Soprano, Paolo M, additional, Ntai, Aikaterini, additional, Barozzi, Serena, additional, La Spada, Alberto, additional, Biunno, Ida, additional, Raslova, Hana, additional, Bussel, James B, additional, Kaplan, David L, additional, Balduini, Carlo L, additional, Pecci, Alessandro, additional, and Balduini, Alessandra, additional

Published
2021
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138. Fc receptors in immune thrombocytopenias: a target for immunomodulation?

Author

Psaila, Bethan and Bussel, James B.

Subjects
Immunotherapy -- Health aspects, Thrombocytopenia -- Care and treatment, Thrombocytopenia -- Prevention, Thrombocytopenia -- Research, Fc receptors -- Physiological aspects, Fc receptors -- Research
Abstract

In autoimmune disease, Fc receptors (FcRs) form the interface between immune effector cells and their antibody-coated targets, and as such are attractive targets for immunomodulatory therapy. In this issue of the JCI, two highly novel studies of Fc--FcR interactions provide new insights into the role of FcRs in immune thrombocytopenia. Asahi et al. utilized a comprehensive platform of immunological assays to examine the mechanism underlying Helicobacter pylori--associated immune thrombocytopenic purpura, and Ghevaert et al. describe a specially designed antibody that saturates binding sites on fetal platelets without initiating Fc[gamma]R-mediated platelet phagocytosis, preventing the binding of pathological maternal anti-HLA antibodies that cause fetomaternal alloimmune thrombocytopenia (see the related articles beginning on pages 2939 and 2929, respectively). These reports illustrate how a remarkably detailed molecular understanding of the FcR network may translate into new therapeutic strategies with high clinical impact., A focus on the Fc receptor network present on macrophages The interactions between immune cells and their target cells in autoimmune diseases have been the focus of much attention, and [...]

Published
2008

139. Circulating microRNAs in patients with immune thrombocytopenia before and after treatment with thrombopoietin-receptor agonists

Author

Garabet, Lamya, Ghanima, Waleed, Anbjørg Rangberg, Teruel-Montoya, Raul, Martinez, Constantino, Lozano, Maria Luisa, Nystrand, Camilla F., Bussel, James B., Sandset, Per Morten, and Jonassen, Christine M.

Subjects
hemic and lymphatic diseases
Abstract

MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of gene expression. Dysregulated expression of several miRNAs has been found in primary immune thrombocytopenia (ITP) suggesting that miRNAs are likely involved in the pathogenesis of ITP. We aimed to explore the differential expression of miRNAs in patients with ITP before and after starting treatment with thrombopoietin-receptor agonists (TPO-RAs) to clarify their roles in the pathophysiology of ITP, and as potential diagnostic and prognostic markers of this disorder. We performed a profiling study where 179 miRNAs were analyzed in eight ITP patients before and during treatment with TPO-RAs and in eight controls using miRNA PCR panel; 81 miRNAs were differentially expressed in ITP patients compared to controls, and 14 miRNAs showed significant changes during TPO-RA-treatment. Ten miRNAs were selected for validation that was performed in 23 patients and 22 controls using droplet digital PCR. Three miRNAs were found to be differentially expressed in ITP patients before TPO-RA-treatment compared to controls: miR-199a-5p was down-regulated (p = 0.0001), miR-33a-5p (p = 0.0002) and miR-195-5p (p = 0.035) were up-regulated. Treatment with TPO-RAs resulted in changes in six miRNAs including miR-199a-5p (p = 0.001), miR-33a-5p (p = 0.003), miR-382-5p (p = 0.004), miR-92b-3p (p = 0.005), miR-26a-5p (p = 0.008) and miR-221-3p (p = 0.023); while miR-195-5p remained unchanged and significantly higher than in controls, despite the increase in the platelet count, which may indicate its possible role in the pathophysiology of ITP. Regression analysis revealed that pre-treatment levels of miR-199a-5p and miR-221-3p could help to predict platelet response to TPO-RA-treatment. ROC curve analysis showed that the combination of miR-199a-5p and miR-33a-5p could distinguish patients with ITP from controls with AUC of 0.93. This study identifies a number of differentially expressed miRNAs in ITP patients before and after initiation of TPO-RAs with potential roles in the pathophysiology, as well as with a possible utility as diagnostic and prognostic biomarkers. These interesting findings deserve further exploration and validation in future studies.

Published
2020
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140. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura

Author

Bussel, James B., Cheng, Gregory, Saleh, Mansoor N., Psaila, Bethan, Kovaleva, Lidia, Meddeb, Balkis, Kloczko, Janusz, Hassani, Habib, Mayer, Bhabita, Stone, Nicole L., Arning, Michael, Provan, Drew, and Jenkins, Julian M.

Subjects
Platelet activating factor -- Dosage and administration, Platelet activating factor -- Complications and side effects, Thrombocytopenic purpura -- Drug therapy
Abstract

The results from randomized trial conducted to determine thrombopoietin-receptor agonist eltrombopag as an effective treatment among adults with chronic idiopathic thrombocytopenic purpura (ITP) is reported. Eltrombopag was found to increase platelet counts in a dose-dependent manner in patients with relapsed or refractory ITP.

Published
2007

142. List of Contributors

Author

Andrews, Robert K., primary, Aster, Richard H., additional, Atkinson, Ben T, additional, Barnard, Marc R., additional, Bavry, Anthony A., additional, Bayer, Arnold S., additional, Beaulieu, Lea M., additional, Berndt, Michael C., additional, Berny-Lang, Michelle A., additional, Bhatt, Deepak L., additional, Bizzaro, Nicola, additional, Bledzka, Kamila, additional, Bouchard, Beth A., additional, Brass, Lawrence F., additional, Bray, Paul F., additional, Briggs, Carol, additional, Bussel, James B., additional, Cattaneo, Marco, additional, Chakravorty, Subarna, additional, Chong, Beng H., additional, Clemetson, Jeannine, additional, Clemetson, Kenneth J., additional, Coller, Barry S., additional, Covic, Lidija, additional, Davì, Giovanni, additional, del Zoppo, Gregory J., additional, Dowling, Mark R., additional, Dubois, Christophe, additional, Eisert, Wolfgang G., additional, Evangelista, Virgilio, additional, Flaumenhaft, Robert, additional, Freedman, Jane E., additional, Freedman, John, additional, Frelinger, Andrew L., additional, Furie, Barbara C., additional, Furie, Bruce, additional, Gardiner, Chris, additional, Gawaz, Meinrad, additional, Geisler, Tobias, additional, Greinacher, Andreas, additional, Gurbel, Paul A., additional, Harrison, Paul, additional, Hartwig, John H., additional, Hayward, Catherine P.M., additional, Hughes, Craig E., additional, Ikeda, Yasuo, additional, Israels, Sara J., additional, Italiano, Joseph E., additional, Jackson, Shaun, additional, Jain, Shashank, additional, Jones, Chris I., additional, Josefsson, Emma C., additional, Kaplan, Cécile, additional, Kile, Benjamin T., additional, Kimura, Yukio, additional, Klement, Giannoula Lakka, additional, Kolandaivelu, Kumaran, additional, Kuliopulos, Athan, additional, Kuter, David J., additional, Lambert, Michelle P., additional, Langer, Harald F., additional, Lebois, Marion, additional, Levin, Jack, additional, Lordkipanidzé, Marie, additional, Ma, Yan-Qing, additional, Mannucci, Pier Mannuccio, additional, McCrae, Keith R., additional, Merrill-Skoloff, Glenn, additional, Michelson, Alan D., additional, Moffat, Karen A., additional, Mutch, Nicola J., additional, Newman, Debra K., additional, Newman, Peter E., additional, Ni, Heyu, additional, Nieuwland, Rienk, additional, Ouwehand, Willem H., additional, Parsons, Jeremy, additional, Patrono, Carlo, additional, Perrotta, Peter L., additional, Pesho, Michelle M., additional, Plow, Edward F., additional, Politt, Alice Y., additional, Poncz, Mortimer, additional, Poon, Man-Chiu, additional, Provost, Patrick, additional, Psaila, Bethan, additional, Rao, A. Koneti, additional, Rinder, Henry M., additional, Roberts, Irene A.G., additional, Rondina, Matthew T., additional, Ruggeri, Zaverio M., additional, Santilli, Francesca, additional, Schwertz, Hansjörg, additional, Shai, Ela, additional, Silveira, Jay R., additional, Smith, Brian R., additional, Smith, Matthew C., additional, Smyth, Susan S., additional, Snyder, Edward L., additional, Sobel, Michael, additional, Soranzo, Nicole, additional, Stalker, Timothy J., additional, Sturk, Auguste, additional, Sudo, Toshiki, additional, Sullivan, Spencer, additional, Tantry, Udaya S., additional, Tefferi, Ayalew, additional, Tracy, Paul B., additional, Tsai, Han-Mou, additional, van der Pol, Edwin, additional, Varon, David, additional, Vazzana, Natale, additional, Vieira-de-Abreu, Adriana, additional, Wannemacher, Kenneth, additional, Ware, Jerry, additional, Warkentin, Theodore E., additional, Watson, Steve P., additional, Weyrich, Andrew S., additional, White, James G., additional, Wilcox, David A., additional, Yeaman, Michael R., additional, Zhang, Ping, additional, Zhu, Li, additional, and Zimmerman, Guy A., additional

Published
2013
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146. Contributors

Author

Abrams, Charles S., primary, Abshire, Thomas C., additional, Arinsburg, Suzanne A., additional, Avecilla, Scott T., additional, Babic, Aleksandar M., additional, Bellone, Michael, additional, Bennett, Carolyn M., additional, Briones, Michael A., additional, Bussel, James B., additional, Chandler, Wayne L., additional, Csete, Marie, additional, Cuker, Adam C., additional, Cushing, Melissa M., additional, Desormeaux, Marie-Laure, additional, Dodd, Roger Y., additional, Dunn, Amy L., additional, Francis, Richard O., additional, Garbaini, Jennifer, additional, Ginzberg, Yelena Z., additional, Goodrich, Raymond P., additional, Goss, Cheryl A., additional, Greco, Benjamin J., additional, Hendrickson, Jeanne E., additional, Hillyer, Christopher D., additional, Hod, Eldad A., additional, Hume, Heather A., additional, Jalikis, Florencia G., additional, Jobe, Shawn M., additional, Josephson, Casssandra D., additional, Karafin, Matthew S., additional, Karim, Sadiqa, additional, Katz, Louis M., additional, Kempton, Christine L., additional, Kessler, Debra A., additional, Lal, Devika, additional, Lambert, Michele P., additional, Lim, Wendy, additional, Maramica, Irina Knezevic, additional, Marschner, Susanne, additional, Mcguinn, Catherine E., additional, Meeks, Shannon L., additional, Miller, Connie H., additional, Mitchell, W. Beau, additional, Monis, Grace F., additional, Nester, Theresa, additional, Pham, Huy Phu, additional, Quinley, Eva D., additional, Rennert, Hanna, additional, Reyes, Morayma, additional, Rich, Anna-Sophie, additional, Roshal, Mikhail, additional, Ruch, Joshua M., additional, Savage, William J., additional, Scaradavou, Andromachi, additional, Schwartz, Joseph, additional, Shaz, Beth H., additional, Shi, Patricia, additional, Sood, Suman, additional, Weinberg, Rona S., additional, Westhoff, Connie M., additional, Winkler, Anne M., additional, Yan, Jiong, additional, and Zimring, James C., additional

Published
2013
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148. AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP

Author

Bussel, James B., Kuter, David J., Phil, D., George, James N., McMillan, Robert, Aledort, Louis M., Conklin, George T., Lichtin, Alan E., Lyons, Roger M., Nieva, Jorge, Wasser, Jeffrey S., Wiznitzer, Israel, Kelly, Reggie, Chien-Feng Chen, and Nichol, Janet L.

Subjects
Thrombocytopenic purpura -- Risk factors, Thrombocytopenic purpura -- Health aspects, Thrombocytopenic purpura -- Care and treatment
Abstract

The safety and efficacy of treatment with a novel thrombopoiesis-stimulating protein, AMG 531 (Amgen), in patients with immune thrombocytopenic purpura (ITP) are evaluated. The results have shown that AMG 531 caused no major adverse events and increased platelet counts in patients with ITP.

Published
2006

149. Immune thrombocytopenia ( ITP ) World Impact Survey ( I‐WISh ): Impact of ITP on health‐related quality of life

Author

Cooper, Nichola, primary, Kruse, Alexandra, additional, Kruse, Caroline, additional, Watson, Shirley, additional, Morgan, Mervyn, additional, Provan, Drew, additional, Ghanima, Waleed, additional, Arnold, Donald M., additional, Tomiyama, Yoshiaki, additional, Santoro, Cristina, additional, Michel, Marc, additional, Laborde, Serge, additional, Lovrencic, Barbara, additional, Hou, Ming, additional, Bailey, Tom, additional, Taylor‐Stokes, Gavin, additional, Haenig, Jens, additional, and Bussel, James B., additional

Published
2020
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150. Immune thrombocytopenia (ITP) World Impact Survey (iWISh): Patient and physician perceptions of diagnosis, signs and symptoms, and treatment

Author

Cooper, Nichola, primary, Kruse, Alexandra, additional, Kruse, Caroline, additional, Watson, Shirley, additional, Morgan, Mervyn, additional, Provan, Drew, additional, Ghanima, Waleed, additional, Arnold, Donald M., additional, Tomiyama, Yoshiaki, additional, Santoro, Cristina, additional, Michel, Marc, additional, Laborde, Serge, additional, Lovrencic, Barbara, additional, Hou, Ming, additional, Bailey, Tom, additional, Taylor‐Stokes, Gavin, additional, Haenig, Jens, additional, and Bussel, James B., additional

Published
2020
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