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Background: The objective of this review is to evaluate the associations between short-term exposure to radiofrequency electromagnetic fields (RF-EMF) and cognitive performance in human experimental studies. Methods: Online databases (PubMed, Embase, Scopus, Web of Science and EMF-Portal) were searched for studies that evaluated effects of exposure to RF-EMF on seven domains of cognitive performance in human experimental studies. The assessment of study quality was based on the Risk of Bias (RoB) tool developed by the Office of Health Assessment and Translation (OHAT). Random effects meta-analyses of Hedges’s g were conducted separately for accuracy- and speed-related performance measures of various cognitive domains, for which data from at least two studies were available. Finally, the certainty of evidence for each identified outcome was assessed according to Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Results: 57,543 records were identified and 76 studies (80 reports) met the inclusion criteria. The included 76 studies with 3846 participants, consisting of humans of different age, sex and health status from 19 countries, were conducted between 1989 and 2021. Quantitative data from 50 studies (52 reports) with 2433 participants were included into the meta-analyses. These studies were performed in 15 countries between 2001 and 2021. The majority of the included studies used head exposure with GSM 900 uplink.None of the meta-analyses observed a statistically significant effect of RF-EMF exposure compared to sham on cognitive performance as measured by the confidence interval surrounding the Hedges’s g or the significance of the z-statistic.For the domain Orientation and Attention, subclass Attention – Attentional Capacity RF-EMF exposure results in little to no difference in accuracy (Hedges’s g 0.024, 95 % CI [−0.10; 0.15], I2 = 28 %, 473 participants).For the domain Orientation and Attention, subclass Attention – Concentration / Focused Attention RF-EMF exposure results in little to no difference in speed (Hedges’s g 0.005, 95 % CI [−0.17; 0.18], I2 = 7 %, 132 participants) and probably results in little to no difference in accuracy; it does not reduce accuracy (Hedges’s g 0.097, 95 % CI [−0.05; 0.24], I2 = 0 %, 217 participants).For the domain Orientation and Attention, subclass Attention – Vigilance RF-EMF exposure probably results in little to no difference in speed and does not reduce speed (Hedges’s g 0.118, 95 % CI [−0.04; 0.28], I2 = 41 %, 247 participants) and results in little to no difference in accuracy (Hedges’s g 0.042, 95 % CI, [−0.09; 0.18], I2 = 0 %, 199 participants).For the domain Orientation and Attention, subclass Attention – Selective Attention RF-EMF exposure probably results in little to no difference in speed and does not reduce speed (Hedges’s g 0.080, 95 % CI [−0.09; 0.25], I2 = 63 %, 452 participants); it may result in little to no difference in accuracy, but it probably does not reduce accuracy (Hedges’s g 0.178, 95 % CI [−0.02; 0.38], I2 = 68 %, 480 participants).For the domain Orientation and Attention, subclass Attention – Divided Attention RF-EMF exposure results in little to no difference in speed (Hedges’s g −0.010, 95 % CI [−0.14; 0.12], I2 = 5 %, 307 participants) and may result in little to no difference in accuracy (Hedges’s g −0.089, 95 % CI [−0.35; 0.18], I2 = 53 %, 167 participants).For the domain Orientation and Attention, subclass Processing Speed − Simple Reaction Time Task RF-EMF exposure results in little to no difference in speed (Hedges’s g 0.069, 95 % CI [−0.02; +0.16], I2 = 29 %, 820 participants).For the domain Orientation and Attention, subclass Processing Speed – 2-Choice Reaction Time Task RF-EMF exposure results in little to no difference in speed (Hedges’s g −0.023, 95 % CI [−0.13; 0.08], I2 = 0 %, 401 participants), and may result in little to no difference in accuracy (Hedges’s g −0.063, 95 % CI [−0.38; 0.25], I2 = 63 %, 117 participants).For the domain Orientation and Attention, subclass Processing Speed – >2-Choice Reaction Time Task RF-EMF exposure results in little to no difference in speed (Hedges’s g −0.054, 95 % CI [−0.14; 0.03], I2 = 0 %, 544 participants) and probably results in little to no difference in accuracy (Hedges’s g −0.129, 95 % CI [−0.30; 0.04], I2 = 0 %, 131 participants).For the domain Orientation and Attention, subclass Processing Speed – Other Tasks RF-EMF exposure probably results in little to no difference in speed and does not reduce speed (Hedges’s g 0.067, 95 % CI [−0.12; 0.26], I2 = 38 %, 249 participants); it results in little to no difference in accuracy (Hedges’s g 0.036, 95 % CI [−0.08; 0.15], I2 = 0 %, 354 participants).For the domain Orientation and Attention, subclass Working Memory – n-back Task (0–3-back) we found Hedges’s g ranging from −0.090, 95 % CI [−0.18; 0.01] to 0.060, 95 % CI [−0.06; 0.18], all I2 = 0 %, 237 to 474 participants, and conclude that RF-EMF exposure results in little to no difference in both speed and accuracy.For the domain Orientation and Attention, subclass Working Memory – Mental Tracking RF-EMF exposure results in little to no difference in accuracy (Hedges’s g −0.047, 95 % [CI −0.15; 0.05], I2 = 0 %, 438 participants).For the domain Perception, subclass Visual and Auditory Perception RF-EMF exposure may result in little to no difference in speed (Hedges’s g −0.015, 95 % CI [−0.23; 0.195], I2 = 0 %, 84 participants) and probably results in little to no difference in accuracy (Hedges’s g 0.035, 95 % CI [−0.13; 0.199], I2 = 0 %, 137 participants).For the domain Memory, subclass Verbal and Visual Memory RF-EMF exposure probably results in little to no difference in speed and does not reduce speed (Hedges’s g 0.042, 95 % CI [−0.15; 0.23], I2 = 0 %, 102 participants); it may result in little to no difference in accuracy (Hedges’s g −0.087, 95 % CI [−0.38; 0.20], I2 = 85 %, 625 participants).For the domain Verbal Functions and Language Skills, subclass Verbal Expression, a meta-analysis was not possible because one of the two included studies did not provide numerical values. Results of both studies did not indicate statistically significant effects of RF-EMF exposure on both speed and accuracy.For the domain Construction and Motor Performance, subclass Motor Skills RF-EMF exposure may reduce speed, but the evidence is very uncertain (Hedges’s g −0.919, 95 % CI [−3.09; 1.26], I2 = 96 %, 42 participants); it probably results in little to no difference in accuracy and does not reduce accuracy (Hedges’s g 0.228, 95 % CI [−0.01; 0.46], I2 = 0 %, 109 participants).For the domain Concept Formation and Reasoning, subclass Reasoning RF-EMF exposure results in little to no difference in speed (Hedges’s g 0.010, 95 % CI [−0.11; 0.13], I2 = 0 %, 263 participants) and probably results in little to no difference in accuracy and does not reduce accuracy (Hedges’s g 0.051, 95 % CI [−0.14; 0.25], I2 = 0 %, 100 participants).For the domain Concept Formation and Reasoning, subclass Mathematical Procedures RF-EMF exposure results in little to no difference in speed (Hedges’s g 0.033, 95 % CI [−0.12; 0.18], I2 = 0 %, 168 participants) and may result in little to no difference in accuracy but probably does not reduce accuracy (Hedges’s g 0.232, 95 % CI [−0.12; +0.59], I2 = 86 %, 253 participants).For the domain Executive Functions there were no studies. Discussion: Overall, the results from all domains and subclasses across their speed- and accuracy-related outcome measures according to GRADE provide high to low certainty of evidence that short-term RF-EMF exposure does not reduce cognitive performance in human experimental studies. For 16 out of 35 subdomains some uncertainty remains, because of limitations in the study quality, inconsistency in the results or imprecision of the combined effect size estimate. Future research should focus on construction and motor performance, elderly, and consideration of both sexes. Other: This review was partially funded by the WHO radioprotection programme.The protocol for this review was registered in Prospero reg. no. CRD42021236168 and published in Environment International (Pophof et al. 2021).

IntroductionSpecial Operations Forces (SOF) often conduct operations in physiologically stressful environments such as severe heat, cold, or hypoxia, which can induce decreases in a variety of cognitive abilities. Given the promising empirical demonstration of the efficacy of exogenous ketone monoester (KME) supplementation in attenuating cognitive performance decrease during hypoxia at rest in a laboratory setting, we conducted a real-world, field experiment examining KME’s efficacy during high-altitude mountaineering, an austere environment in which US SOF have conducted increasing numbers of operations over the past two decades.MethodsSpecifically, 34 students and cadre at the US Army 10th Special Forces Group Special Operations Advanced Mountaineering School (SOAMS) participated in a randomized, double-blind, placebo (PLA)–controlled crossover trial (KME vs. PLA) over 2 days of tactical mountain operations training. The participants ascended from 7,500 ft in altitude (basecamp) to 12,460 ft on 1 day and 13,627 ft the other day (in randomized order), while performing various training activities inducing high physical and cognitive loads over 8–12 h, and consumed six doses of KME or PLA 2–3 h apart throughout each training day.Results and DiscussionWhile KME increased blood ketone levels and decreased glucose levels, there were no clear indications that the elevated ketone level enhanced physical or cognitive performance. KME also produced a greater incidence of heartburn, nausea, and vomiting. In these elite operators, high-altitude mountaineering had a limited impact on cognitive performance, and KME supplementation did not demonstrate any benefit.

The article is a commentary on a review of the evidence regarding the composition and health effects of pork meat. The author disagrees with the conclusions of the review, stating that it overlooked adverse effects of eating red and processed meat and overestimated its sustainability. The author cites other studies that suggest red and processed meat are associated with increased risks of cardiovascular disease, cancer, dementia, type 2 diabetes mellitus, and other health conditions. They also argue that pork meat negatively affects cognitive performance and contributes to the risk of Alzheimer's disease. The author concludes that eating pork has many adverse health effects, especially in mid- and late life. [Extracted from the article]

The aim of this systematic review was to examine the effects of physical exercise training on cerebral blood flow (CBF), which is a physiological marker of cerebrovascular function. Relationships between training-induced effects on CBF with changes in cognitive performance were also discussed. A systematic search was performed up to July 2022. Forty-five intervention studies with experimental, quasi-experimental, or pre–post designs were included. Sixteen studies (median duration: 14 weeks) investigated effects of physical exercise training on CBF markers using magnetic resonance imaging, 20 studies (median duration: 14 weeks) used transcranial Doppler ultrasound, and eight studies (median duration: 8 weeks) used near-infrared spectroscopy. Studies using magnetic resonance imaging observed consistent increases in CBF in the anterior cingulate cortex and hippocampus, but not in whole-brain CBF. Effects on resting CBF—measured with transcranial Doppler ultrasound and near-infrared spectroscopy—were variable, while middle cerebral artery blood flow velocity increased in some studies following exercise or hypercapnic stimuli. Interestingly, concomitant changes in physical fitness and regional CBF were observed, while a relation between training-induced effects on CBF and cognitive performance was evident. In conclusion, exercise training improved cerebrovascular function because regional CBF was changed. Studies are however still needed to establish whether exercise-induced improvements in CBF are sustained over longer periods of time and underlie the observed beneficial effects on cognitive performance. [ABSTRACT FROM AUTHOR]

Introduction and purpose: Noise is one of the most harmful physical factors in workplaces in both developed and developing countries. Still, low-frequency noise has not received enough attention, and the current regulations on its control are inadequate. To address this issue, the present study was conducted to examine the physiological response and cognitive functions of individuals before and after exposure to low-frequency noise. Methods: This study was conducted in the solar year 1401 and involved 40 students from Mazandaran University of Medical Sciences. Low-frequency noise with a level of 65 dB A was played for one hour. The patients' heart rates, blood pressure, and core temperatures were collected before and after exposure to low-frequency noise. Moreover, the continuous performance test was used to examine their cognitive performance. The data was analyzed using the Friedman and Voilcoxon tests in SPSS 25 software. Results: Low-frequency noise adversely impacted individual cognitive performance, increasing response error, omission error, and reaction time. However, according to the Wilcoxon test, only the increase in reaction time was statistically significant (P0.05). Conclusion: Exposure to low-frequency noise generates greater discomfort than background noise with the same intensity level and has adverse effects on the individual's performance. Thus, the adverse effects of low-frequency noise are particularly significant in workstations that require mental processing of information and specific attention, such as control rooms and offices.

Abstract Background Obstructive sleep apnea (OSA) is a pervasive, chronic sleep-related respiratory condition that causes brain structural alterations and cognitive impairments. However, the causal association of OSA with brain morphology and cognitive performance has not been determined. Methods We conducted a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the causal relationship between OSA and a range of neurocognitive characteristics, including brain cortical structure, brain subcortical structure, brain structural change across the lifespan, and cognitive performance. Summary-level GWAS data for OSA from the FinnGen consortium was used to identify genetically predicted OSA. Data regarding neurocognitive characteristics were obtained from published meta-analysis studies. Linkage disequilibrium score regression analysis was employed to reveal genetic correlations between OSA and related traits. Results Our MR study provided evidence that OSA was found to significantly increase the volume of the hippocampus (IVW β (95% CI) = 158.997 (76.768 to 241.227), P = 1.51e-04), with no heterogeneity and pleiotropy detected. Nominally causal effects of OSA on brain structures, such as the thickness of the temporal pole with or without global weighted, amygdala structure change, and cerebellum white matter change covering lifespan, were observed. Bidirectional causal links were also detected between brain cortical structure, brain subcortical, cognitive performance, and OSA risk. LDSC regression analysis showed no significant correlation between OSA and hippocampus volume. Conclusions Overall, we observed a positive association between genetically predicted OSA and hippocampus volume. These findings may provide new insights into the bidirectional links between OSA and neurocognitive features, including brain morphology and cognitive performance.

Abstract Purpose Previous studies suggest an association between chronic kidney disease (CKD) and cognitive impairment. The purpose of this study was to explore the association between the diverse stages of CKD and the cognitive performance of elderly American adults. Methods Data from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 were used. Multivariate adjusted logistic regression, subgroup analysis, and the restricted cubic spline model were used to assess the associations of CKD stage and estimated glomerular filtration rate (eGFR) with cognitive performance. The measures used to evaluate cognitive function included the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) test, the Animal Fluency test, and the Digit Symbol Substitution test (DSST). Results This study included 2234 participants aged ≥ 60 years. According to the fully adjusted model, stages 3–5 CKD were significantly associated with the CERAD test score (OR = 0.70, 95% CI [0.51, 0.97], p = 0.033), the Animal Fluency test score (OR = 0.64, 95% CI [0.48, 0.85], p = 0.005), and the DSST score (OR = 0.60, 95% CI [0.41, 0.88], p = 0.013). In addition, the incidence of poor cognitive function increased with decreasing eGFR, especially for individuals with low and moderate eGFRs. Both the DSST score (p nonlinearity

Objectives: The prevalence of multiple health hazards in various industries is on the rise, with noise and heat being common harmful factors in industrial environments in Iran. This study aimed to examine the immediate effects of simultaneous exposure to thermal stress and noise on human brain waves and perceived workload.Methods: Seventy-two students (36 men and 36 women) participated voluntarily in this study. Participants were subjected to varying levels of noise exposure, including four noise levels and heat stress (three levels of Wet Bulb Globe Temperature) for 30 minutes each. EEG recordings were conducted for 10 minutes, with participants allowed a 30-minute rest period between each test condition.Results: The combined exposure to noise and heat at two high levels (SPL95+WBGT34 and SPL95+WBGT29) resulted in a significant increase in perceived mental workload compared to the baseline state (P

Abstract Background White matter hyperintensities (WMHs) are often measured globally, but spatial patterns of WMHs could underlie different risk factors and neuropathological and clinical correlates. We investigated the spatial heterogeneity of WMHs and their association with comorbidities, Alzheimer’s disease (AD) risk factors, and cognition. Methods In this cross-sectional study, we studied 171 cognitively unimpaired (CU; median age: 65 years, range: 50 to 89) and 51 mildly cognitively impaired (MCI; median age: 72, range: 53 to 89) individuals with available amyloid (18F-flutementamol) PET and FLAIR-weighted images. Comorbidities were assessed using the Cumulative Illness Rating Scale (CIRS). Each participant’s white matter was segmented into 38 parcels, and WMH volume was calculated in each parcel. Correlated principal component analysis was applied to the parceled WMH data to determine patterns of WMH covariation. Adjusted and unadjusted linear regression models were used to investigate associations of component scores with comorbidities and AD-related factors. Using multiple linear regression, we tested whether WMH component scores predicted cognitive performance. Results Principal component analysis identified four WMH components that broadly describe FLAIR signal hyperintensities in posterior, periventricular, and deep white matter regions, as well as basal ganglia and thalamic structures. In CU individuals, hypertension was associated with all patterns except the periventricular component. MCI individuals showed more diverse associations. The posterior and deep components were associated with renal disorders, the periventricular component was associated with increased amyloid, and the subcortical gray matter structures was associated with sleep disorders, endocrine/metabolic disorders, and increased amyloid. In the combined sample (CU + MCI), the main effects of WMH components were not associated with cognition but predicted poorer episodic memory performance in the presence of increased amyloid. No interaction between hypertension and the number of comorbidities on component scores was observed. Conclusion Our study underscores the significance of understanding the regional distribution patterns of WMHs and the valuable insights that risk factors can offer regarding their underlying causes. Moreover, patterns of hyperintensities in periventricular regions and deep gray matter structures may have more pronounced cognitive implications, especially when amyloid pathology is also present.

Abstract Background Having rich social networks is associated with better physical and cognitive health, however older adults entering long-term care may experience an increased risk of social isolation and consequent negative impacts on cognitive function. Our study aimed to identify if there is an association between accessing specific types of services or activities within long-term care on social networks and cognition. Methods A cross-sectional study of 96 residents from 2 aged care providers in New South Wales, Australia. Residents were given a battery of assessments measuring social network structure (Lubben Social Network Scale, LSNS-12), quality of life (EuroQol 5D, Eq. 5D5L) and cognitive function (Montreal Cognitive Assessment, MoCA). Demographic factors and service use factors were also collected from aged care providers’ electronic records. Independent sample t-test, ANOVA and linear regression analyses were used to explore associated factors for cognition. Results Residents had a mean age of 82.7 ± 9.4 years (median = 81) and 64.6% were women. Most residents had cognitive impairment (70.8%) and reported moderate sized social networks (26.7/60) (Lubben Social Network Scale, LSNS-12). Residents who had larger social networks of both family and friends had significantly better cognitive performance. Service type and frequency of attendance were not associated with cognitive function. Conclusions Among individuals most at risk of social isolation, having supportive and fulfilling social networks was associated with preserved cognitive function. The relationship between service provision and social interactions that offer psychosocial support within long-term facilities and its impact over time on cognitive function requires further exploration.

The aim of this study was to analyze the acute effects of an incremental resistance test on psychomotor vigilance in 16 soccer players under-19 years old (age 16.42 ± 0.85 years). Borg 15-point subjective perception of effort scale, the psychomotor vigilance task test, and the Yo-Yo intermittent recovery test were used. Four evaluation sessions were conducted with different intensities of efforts (30%-40%, 60%-75%, 80%-90%, and 100%) on different days (counterbalanced order). A repeated-measures analysis of variance was performed in the reaction time of the psychomotor vigilance task. The results showed that participants responded faster during efforts between 80% and 90% of maximal oxygen uptake (501.20 ± 70.77 ms). From that threshold, the players decreased their performance through a longer reaction time (601.23 ± 85.05 ms; p value < .001). The main findings were that the reaction time performance was worse at the lowest and highest effort conditions (5 and 17 km/hr, respectively). This fact helps to focus on the importance of designing and proposing training tasks with medium-high efforts to provoke optimal reaction times in young soccer players. [ABSTRACT FROM AUTHOR]

Purpose: Professional football players experience both physical and mental fatigue (MF). The main aims of this randomized crossover study were to investigate the effect of MF on repeated-sprint ability (RSA) and the effects of both physical fatigue and MF on psychomotor vigilance. Methods: Seventeen male professional football players performed 10 maximal 20-m shuttle sprints interspaced by incomplete recovery (RSA test). Running speed, heart rate, brain oxygenation, and rating of perceived exertion were monitored during each sprint. The RSA test was preceded by either a 30-minute Stroop task to induce MF or by watching a documentary for 30 minutes (control [CON]) in a randomized counterbalanced order. Participants performed a psychomotor vigilance test at baseline, after the cognitive task (MF or CON), and after the RSA test. Results: Heart rate and rating of perceived exertion significantly increased, while running speed and brain oxygenation significantly decreased over the repeated sprints (P <.001) with no significant differences between conditions. Response speed during the psychomotor vigilance test significantly declined after the Stroop task but not after CON (P =.001). Response speed during the psychomotor vigilance test declined after the RSA test in both conditions (P <.001) and remained lower in the MF condition compared to CON (P =.012). Conclusions: MF does not reduce RSA. However, the results of this study suggest that physical fatigue and MF have negative and cumulative effects on psychomotor vigilance. Therefore, strategies to reduce both physical fatigue and MF should be implemented in professional football players. [ABSTRACT FROM AUTHOR]

INTRODUCTION: Apolipoprotein E (APOE) is considered the major susceptibility gene for developing Alzheimers disease. However, the strength of this risk factor is not well established across diverse Hispanic populations. METHODS: We investigated the associations among APOE genotype, dementia prevalence, and memory performance (immediate and delayed recall scores) in Caribbean Hispanics (CH), African Americans (AA), Hispanic Americans (HA) and non-Hispanic White Americans (NHW). Multivariable logistic regressions and negative binomial regressions were used to examine these associations by subsample. RESULTS: Our final dataset included 13,516 participants (5198 men, 8318 women) across all subsamples, with a mean age of 74.8 years. Prevalence of APOE ε4 allele was similar in CHs, HAs, and NHWs (21.8%-25.4%), but was substantially higher in AAs (33.6%; P

Summary The purpose of this study was to investigate the association between chronic sleep duration and reaction time performance and motor preparation during a simple reaction time task with a startling acoustic stimulus in adults. This cross‐sectional study included self‐reported short sleepers (n = 25, ≤ 6 hr per night) and adequate sleepers (n = 25, ≥ 7.5 hr per night) who performed a simple reaction time task requiring a targeted ballistic wrist extension in response to either a control‐tone (80 dB) or a startling acoustic stimulus (120 dB). Outcome measures included reaction times for each stimulus (overall and for each trial block), lapses, and proportion of startle responses. Chronic short sleepers slept on average 5.7 hr per night in the previous month, which was 2.8 hr per night less than the adequate sleepers. Results revealed an interaction between sleep duration group and stimulus type; the short sleepers had significantly slower control‐tone reaction times compared with adequate sleepers, but there was no significant difference in reaction time between groups for the startling acoustic stimulus. Further investigation showed that chronic short sleepers had significantly slower control‐tone reaction times after two blocks of trials lasting about 5 min, until the end of the task. Lapses were not significantly different between groups. Chronic short sleep duration was associated with poorer performance; however, these reaction time deficits cannot be attributed to motor preparation, as startling acoustic stimulus reaction times were not different between sleep duration groups. While time‐on‐task performance decrements were associated with chronic sleep duration, alertness was not. Sleeping less than the recommended sleep duration on a regular basis is associated with poorer cognitive performance, which becomes evident after 5 min. [ABSTRACT FROM AUTHOR]

Previous studies have suggested a potential association between gut microbiota and neurological and psychiatric disorders. However, the causal relationship between gut microbiota and cognitive performance remains uncertain. A two-sample Mendelian randomization (MR) study used SNPs linked to gut microbiota (n = 18,340) and cognitive performance (n = 257,841) from recent GWAS data. Inverse-variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode were employed. Heterogeneity was assessed via Cochran's Q test for IVW. Results were shown with funnel plots. Outliers were detected through leave-one-out method. MR-PRESSO and MR-Egger intercept tests were conducted to address horizontal pleiotropy influence. Limited to European populations, generic level, and potential confounding factors. IVW analysis revealed detrimental effects on cognitive perfmance associated with the presence of genus Blautia (P = 0.013, 0.966[0.940–0.993]), Catenibacterium (P = 0.035, 0.977[0.956–0.998]), Oxalobacter (P = 0.043, 0.979[0.960–0.999]). Roseburia (P < 0.001, 0.935[0.906–0.965]), in particular, remained strongly negatively associated with cognitive performance after Bonferroni correction. Conversely, families including Bacteroidaceae (P = 0.043, 1.040[1.001–1.081]), Rikenellaceae (P = 0.047, 1.026[1.000–1.053]), along with genera including Paraprevotella (P = 0.044, 1.020[1.001–1.039]), Ruminococcus torques group (P = 0.016, 1.062[1.011–1.115]), Bacteroides (P = 0.043, 1.040[1.001–1.081]), Dialister (P = 0.027, 1.039[1.004–1.074]), Paraprevotella (P = 0.044, 1.020[1.001–1.039]) and Ruminococcaceae UCG003 (P = 0.007, 1.040[1.011–1.070]) had a protective effect on cognitive performance. Our results suggest that interventions targeting specific gut microbiota may offer a promising avenue for improving cognitive function in diseased populations. The practical application of these findings has the potential to enhance cognitive performance, thereby improving overall quality of life. • A bidirectional two-sample MR analysis was performed to explore the causal effect between gut microbiota and cognitive performance. • IVW analysis showed that four gut microbiotas impaired cognitive performance. • Two families and six genera of gut microbiotas had protective effects on cognitive performance. • We provided compelling evidence that specific gut microbiotas play an important role in cognitive performance. [ABSTRACT FROM AUTHOR]

Background: Obstructive sleep apnea (OSA) is a pervasive, chronic sleep-related respiratory condition that causes brain structural alterations and cognitive impairments. However, the causal association of OSA with brain morphology and cognitive performance has not been determined. Methods: We conducted a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the causal relationship between OSA and a range of neurocognitive characteristics, including brain cortical structure, brain subcortical structure, brain structural change across the lifespan, and cognitive performance. Summary-level GWAS data for OSA from the FinnGen consortium was used to identify genetically predicted OSA. Data regarding neurocognitive characteristics were obtained from published meta-analysis studies. Linkage disequilibrium score regression analysis was employed to reveal genetic correlations between OSA and related traits. Results: Our MR study provided evidence that OSA was found to significantly increase the volume of the hippocampus (IVW β (95% CI) = 158.997 (76.768 to 241.227), P = 1.51e-04), with no heterogeneity and pleiotropy detected. Nominally causal effects of OSA on brain structures, such as the thickness of the temporal pole with or without global weighted, amygdala structure change, and cerebellum white matter change covering lifespan, were observed. Bidirectional causal links were also detected between brain cortical structure, brain subcortical, cognitive performance, and OSA risk. LDSC regression analysis showed no significant correlation between OSA and hippocampus volume. Conclusions: Overall, we observed a positive association between genetically predicted OSA and hippocampus volume. These findings may provide new insights into the bidirectional links between OSA and neurocognitive features, including brain morphology and cognitive performance. [ABSTRACT FROM AUTHOR]

AbstractIn the human-machine system of armored vehicles, the cognitive performance state of crews is crucial for the personnel security and combat efficiency. The purpose of this research was to establish a real-time assessment system for cognitive performances of armored vehicle crews, consisting of the data input module, data processing module, data visualization module, and scheduling module. Forty subjects were recruited to cooperate and execute the cross-platform strike task in a virtual simulation platform. The physiological data and operation behavior data was collected during the experiment process. To realize the accurate classification of different cognitive performance states, a multi-source information fusion algorithm was developed based on linear discriminant analysis (LDA) and D-S evidence theory, which included the information collection module, the feature extraction module, and the information fusion module. The results indicated that there existed a significant correlation between the extractive feature indicators (i.e., EOG, ECG, and task performance indicators) and the cognitive performance. The recognition accuracy and the data efficiency of the proposed assessment system were 91.25% and 96.69% respectively by using the complementarity of different evidences, which were higher than the others using partial information sources. This study can provide a reference for the comprehensive assessment of cognitive performance of human operators in military and industrial domains. [ABSTRACT FROM AUTHOR]

Patients with fibromyalgia syndrome tend to report deficits in cognitive functions; however, there is no clear consensus on which cognitive domains are impaired. The aim of this study was to compare the differences in cognitive performance between a group of patients with fibromyalgia syndrome and a group of pain-free subjects controlling for the covariables anxiety, depression, and sleep quality. In total, 130 patients with fibromyalgia syndrome and 111 pain-free subjects with an average age of 54.96 years completed the evaluation protocol consisting of sociodemographic data, psychological data, and neurocognitive tests. All data were collected from May 2022 to May 2023. Multivariate analyses of covariance (MANCOVAs) were conducted to assess intergroup differences in all neurocognitive tests. MANCOVA analyses showed that the group of patients with fibromyalgia showed a worse cognitive performance than the group of pain-free subjects after controlling for anxiety, depression, and sleep quality. This study found that fibromyalgia patients exhibited worse cognitive performance and executive function than pain-free subjects. Thus, cognitive performance seems to not be related with anxiety, depression, or sleep quality in our sample of women with FMS. [ABSTRACT FROM AUTHOR]

Multiple sclerosis (MS) is primarily a disease diagnosed in young and middle-aged adults. Although MS is a rare condition in pediatric age, an increasing rate of patients is diagnosed under the age of 18. The disabling nature of the disease cannot be reduced only to physical symptoms. Several additional symptoms such as cognitive impairment, fatigue, and psychological symptoms are common features of pediatric MS. The reviewed literature suggests that, despite the lower physical disability, children and adolescents diagnosed with MS are vulnerable to cognitive impairment even in the early stage of the disease. The neuropsychological profile of pediatric MS may resemble that of adult MS, including an impairment in attention/information processing speed, learning, verbal, and visuospatial memory. However, cognitive difficulties in children and adolescents are more likely to involve also general intelligence and linguistic abilities, presumably due to patients' younger age and cognitive growth stage. Cognitive difficulties, beyond physical disability and relapses, may have a considerable impact on learning and school achievement. Depression and fatigue are other highly prevalent disturbances in pediatric MS and may contribute to patients' low functional outcomes. Overall, these manifestations may cause considerable functional impairment on daily activities and quality of life that may require individualized rehabilitative treatment and extensive psychosocial care. Additional neuropsychological research evaluating larger samples, using more homogenous methods, and exploring the role of MS treatment on cognitive and psychological development is required. [ABSTRACT FROM AUTHOR]

The Vendée Globe is a non-stop, unassisted, single-handed round the world sailing race. It is regarded as the toughest sailing race, requiring high cognitive functioning and constant alertness. Little is known about the amount of sleep restriction and nutritional deficit experienced at sea and effects that fatigue have on sailors' performance. This report aimed to investigate these aspects by monitoring one of the female participants of the latest Vendée Globe. Sleep, food intake and stress were self-reported daily using specific app. Cognitive assessments were digitally completed. Heart rate and activity intensity were measured using a wrist-worn wearable device. Mean self-report sleep duration per 24 h was 3 hours 40 minutes. By the end of the 95 race days, the sailor reached a caloric deficit of 27,900 kcal. On average, the sailor spent 50 minutes per day in moderate-to-vigorous activity. Cognitive assessments did not show any effect of fatigue or stress on completion time or performance. Recent technological and communication advancement for offshore sailors, enabled continuous data to be monitored in near real time, even from the Southern Ocean. Moving forward this will enable greater understanding of when sailors will be at risk of poor decision making, illness or injury. [ABSTRACT FROM AUTHOR]

To assess the feasibility of methods and estimate the potential effect of interrupting sedentary behaviour, with intermittent or continuous physical activity breaks, on cognitive performance in young people with Cerebral Palsy. A randomised three-arm exposure response cross-over design with process evaluation. Participants were recruited throughout the Thames Valley, UK between 01/11/2018 to 31/03/2020. The three 2 h activity exposure visits included: (i) sitting only (controls), (ii) sitting plus 20 min of moderate-to-vigorous activity burst, or (iii) 4×5 min of moderate-to-vigorous activity bursts, during a 2.5 h sedentary session. Measures of feasibility were sought. Cognitive performance outcomes (using the Eriksen Flanker task and Forward and Backward Digit Span) were delivered before and after the 2 h testing period. 36 participants were randomised (age 13.2±2.7, Gross-Motor Functional Classification System 1–3). Study retention was 83 % across all three interventions and overall missing data for measures was 4 %. A small intervention effect was found in reaction time in the 4×5 min physical activity exposure session compared to the sedentary control condition (0.42; 95 % CI 0.40 to 0.79). There were two research-related minor adverse effects, an allergic reaction to the FreeStyle Libre and feeling faint and vomiting after consumption of glucose solution. Both events were resolved and participants continued with the study. The study design and intervention implementing short bursts of physical activity was feasible and indicated a potential effect on reaction time as a measure of cognitive performance in young people with cerebral palsy. [ABSTRACT FROM AUTHOR]

Despite the well-known physical and mental health benefits of regular exercise, many of the world's population, including healthy young adults, grossly undershoot recommended physical activity levels. Chronic exercise has potential to improve cognitive performance and affect in most age groups. However, there is currently a poverty of relevant research in young adults, especially randomised controlled trials. To address this, the current research investigated the effects of a running intervention on neuropsychological function (cognition and affect) in young adults. We predicted that following a running intervention, neuropsychological performance would improve alongside increases in aerobic fitness. Thirty-two healthy young adult university students were randomised (using a 3:1 ratio) into an intervention or control group, with the intervention group (n = 24) asked to run for 30 min three times a week over a 6-week period and the control group (n = 8) asked to maintain their current level of exercise over a 6-week period. We assessed fitness, cognitive performance, affect and running enjoyment at baseline and follow-up, and runners recorded the environmental conditions of their runs. Repeated measures ANCOVAs failed to find any significant effects of the running intervention on fitness or the neuropsychological measures. Anecdotal evidence supported running environment and enjoyment as potentially relevant factors. The failure to find any fitness improvements, which likely underpins the lack of neuropsychological improvements, highlights the importance of monitoring exercise sessions. Coupled with other insights gained from this trial, this article may prove useful towards future endeavours to develop exercise interventions beneficial to young adults. TRN: ACTRN12621000242820, Date of registration: 08/03/2021. [ABSTRACT FROM AUTHOR]

Aim: Schizophrenia involves complex interactions between biological and environmental factors, including childhood trauma, cognitive impairments, and premorbid adjustment. Predicting its severity and progression remains challenging. Biomarkers like glial cell line-derived neurotrophic factor (GDNF) and miRNA-29a may bridge biological and environmental aspects. The goal was to explore the connections between miRNAs and neural proteins and cognitive functioning, childhood trauma, and premorbid adjustment in the first episode of psychosis (FEP). Method: This study included 19 FEP patients who underwent clinical evaluation with: the Childhood Trauma Questionnaire (CTQ), the Premorbid Adjustment Scale (PAS), the Positive and Negative Syndrome Scale (PANSS), and the Montreal Cognitive Assessment Scale (MoCA). Multiplex assays for plasma proteins were conducted with Luminex xMAP technology. Additionally, miRNA levels were quantitatively determined through RNA extraction, cDNA synthesis, and RT- qPCR on a 7500 Fast Real-Time PCR System. Results: Among miRNAs, only miR-29a-3p exhibited a significant correlation with PAS-C scores (r = -0.513, p = 0.025) and cognitive improvement (r = -0.505, p = 0.033). Among the analyzed proteins, only GDNF showed correlations with MoCA scores at the baseline and after 3 months (r = 0.533, p = 0.0189 and r = 0.598, p = 0.007), cognitive improvement (r = 0.511, p = 0.025), and CTQ subtests. MIF concentrations correlated with the PAS-C subscale (r = -0.5670, p = 0.011). Conclusion: GDNF and miR-29a-3p are promising as biomarkers for understanding and addressing cognitive deficits in psychosis. This study links miRNA and MIF to premorbid adjustment and reveals GDNF's unique role in connection with childhood trauma. [ABSTRACT FROM AUTHOR]

Alzheimer's disease is associated with protein aggregation, oxidative stress, and the role of acetylcholinesterase in the pathology of the disease. Previous investigations have demonstrated that geniposide and harpagoside protect the brain neurons, and cerium nanoparticles (CeO2 NPs) have potent redox and antioxidant properties. Thus, the effect of nanoparticles of Ce NPs and geniposide and harpagoside (GH/CeO2 NPs) on ameliorating AD pathogenesis was established on AlCl3-induced AD in mice and an aggregation proteins test in vitro. Findings of spectroscopy analysis have revealed that GH/CeO2 NPs are highly stable, nano-size, spherical in shape, amorphous nature, and a total encapsulation of GH in cerium. Treatments with CeO2 NPs, GH/CeO2 NPs, and donepezil used as positive control inhibit fibril formation and protein aggregation, protect structural modifications in the BSA-ribose system, have the ability to counteract Tau protein aggregation and amyloid-β1–42 aggregation under fibrillation condition, and are able to inhibit AChE and BuChE. While the GH/CeO2 NPs, treatment in AD induced by AlCl3 inhibited amyloid-β1–42, substantially enhanced the memory, the cognition coordination of movement in part AD pathogenesis may be alleviated through reducing amyloidogenic pathway and AChE and BuChE activities. The findings of this work provide important comprehension of the chemoprotective activities of iridoids combined with nanoparticles. This could be useful in the development of new therapeutic methods for the treatment of neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Purpose: Previous studies suggest an association between chronic kidney disease (CKD) and cognitive impairment. The purpose of this study was to explore the association between the diverse stages of CKD and the cognitive performance of elderly American adults. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 were used. Multivariate adjusted logistic regression, subgroup analysis, and the restricted cubic spline model were used to assess the associations of CKD stage and estimated glomerular filtration rate (eGFR) with cognitive performance. The measures used to evaluate cognitive function included the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test, the Animal Fluency test, and the Digit Symbol Substitution test (DSST). Results: This study included 2234 participants aged ≥ 60 years. According to the fully adjusted model, stages 3–5 CKD were significantly associated with the CERAD test score (OR = 0.70, 95% CI [0.51, 0.97], p = 0.033), the Animal Fluency test score (OR = 0.64, 95% CI [0.48, 0.85], p = 0.005), and the DSST score (OR = 0.60, 95% CI [0.41, 0.88], p = 0.013). In addition, the incidence of poor cognitive function increased with decreasing eGFR, especially for individuals with low and moderate eGFRs. Both the DSST score (p nonlinearity < 0.0001) and the Animal Fluency test score (p nonlinearity = 0.0001) had nonlinear dose–response relationships with the eGFR. However, a linear relationship was shown between the eGFR and CERAD test score (p nonlinearity = 0.073). Conclusions: CKD, especially stages3–5 CKD, was significantly associated with poor cognitive performance in terms of executive function, learning, processing speed, concentration, and working memory ability. All adults with CKD should be screened for cognitive impairment. [ABSTRACT FROM AUTHOR]

The article explores the potential impact of artificial-intelligence chatbots (AICs) on cognitive health. It discusses the interactive and personalized nature of AICs and how they can lead to a deeper cognitive reliance on the chatbots. The article introduces the concept of "AICs induced cognitive atrophy" (AICICA), which refers to the potential deterioration of cognitive abilities resulting from an overreliance on AICs. It emphasizes the need for further research to assess the prevalence and patterns of AICICA, explore long-term cognitive effects, and develop interventions to mitigate AICICA. The article also acknowledges the positive contributions of AICs as external cognitive tools but highlights the importance of a balanced approach and critical thinking skills to avoid potential negative effects. [Extracted from the article]

Very little is known about whether and how socioemotional factors influence age differences in associative memory. Here, we tested the hypothesis that reducing the threat induced by age-based stereotypes can reduce age differences in learning performance and strategy. Using an associative learning task, we replicated the classic finding of age differences under a high-threat condition: older adults had longer reaction times than younger adults and were much more reluctant to use memory retrieval. However, age differences were greatly diminished under a low-threat condition. These findings demonstrate that memory retrieval is an ability not entirely lost as individuals age because merely reducing stereotype threat helped restoring it. We conclude that socioemotional factors, such as stereotype threat, should be considered when evaluating younger and older adults' memory performance. [ABSTRACT FROM AUTHOR]

Background: The hippocampus consists of histologically and functionally distinct subfields, which shows differential vulnerabilities to Alzheimer's disease (AD)-associated pathological changes. Objective: To investigate the atrophy patterns of the main hippocampal subfields in patients with mild cognitive impairment (MCI) and AD and the relationships among the hippocampal subfield volumes, plasma biomarkers and cognitive performance. Methods: This cross-sectional study included 119 patients stratified into three categories: normal cognition (CN; N = 40), MCI (N = 39), and AD (N = 40). AD-related plasma biomarkers were measured, including amyloid-β (Aβ)42, Aβ40, Aβ42/Aβ40 ratio, p-tau181, and p-tau217, and the hippocampal subfield volumes were calculated using automated segmentation and volumetric procedures implemented in FreeSurfer. Results: The subiculum body, cornu ammonis (CA) 1-head, CA1-body, CA4-body, molecular_layer_HP-head, molecular_layer_HP-body, and GC-ML-DG-body volumes were smaller in the MCI group than in the CN group. The subiculum body and CA1-body volumes accurately distinguished MCI from CN (area under the curve [AUC] = 0.647–0.657). The subiculum-body, GC-ML-DG-body, CA4-body, and molecular_layer_HP-body volumes accurately distinguished AD from MCI (AUC = 0.822–0.833) and AD from CN (AUC = 0.903–0.905). The p-tau 217 level served as the best plasma indicator of AD and correlated with broader hippocampal subfield volumes. Moreover, mediation analysis demonstrated that the subiculum-body volume mediated the associations between the p-tau217 and p-tau181 levels, and the Montreal Cognitive Assessment and Auditory Verbal Learning Test recognition scores. Conclusions: Hippocampal subfields with distinctive atrophy patterns may mediate the effects of tau pathology on cognitive function. The subiculum-body may be the most clinically meaningful hippocampal subfield, which could be an effective target region for assessing disease progression. [ABSTRACT FROM AUTHOR]

The aim of this paper was to analyze the acute and chronic effects of physical activity (PA) on cognition, behavior, and motor skill in youth with autism spectrum disorder (ASD), taking into account potential confounders. In addition, it was intended to elaborate a guide of educational applications with strategies for PA use. Studies were identified in four databases from January 2010 to June 2023. A total of 19 interventional studies met the inclusion criteria. PA programs ranged from two weeks to one year in duration, with a frequency of one to five sessions per week. More than 58% of the studies showed positive effects of PA on cognition, and 45.5% on behavior and motor skill. Moderate–vigorous PA for 15–30 min has shown acute effects on cognition, general behavior, and stereotypic/repetitive behaviors in youth with ASD. A total of 9 out of 14 studies showed chronic effects on general behavior and stereotypic behaviors, and only 6 on motor skills. [ABSTRACT FROM AUTHOR]

Objectives: The prevalence of multiple health hazards in various industries is on the rise, with noise and heat being common harmful factors in industrial environments in Iran. This study aimed to examine the immediate effects of simultaneous exposure to thermal stress and noise on human brain waves and perceived workload. Methods: Seventy-two students (36 men and 36 women) participated voluntarily in this study. Participants were subjected to varying levels of noise exposure, including four noise levels and heat stress (three levels of Wet Bulb Globe Temperature) for 30 minutes each. EEG recordings were conducted for 10 minutes, with participants allowed a 30-minute rest period between each test condition. Results: The combined exposure to noise and heat at two high levels (SPL95+WBGT34 and SPL95+WBGT29) resulted in a significant increase in perceived mental workload compared to the baseline state (P<0.05). EEG analysis indicated a decrease in absolute alpha power in the two high-level conditions compared to the baseline (t<0), while absolute beta power showed a significant increase in the two highlevel conditions compared to the baseline mode (SPL45+WBGT22). Conclusion: The study demonstrated that simultaneous exposure to noise and heat, leading to an elevated perceived mental workload, was associated with decreased absolute alpha power and increased absolute beta power in the frontal and occipital regions. These findings suggest that these changes serve as reliable indicators of cognitive and physiological performance. [ABSTRACT FROM AUTHOR]

In two studies, we investigated the effects of workplace bullying on objective measures of cognitive functioning. In Study 1, 47 university employees, self-identified as current targets of bullying (n = 24) or non-targets (n = 23), completed objectively scored cognitive tasks assessing general attention and three components of working memory (central executive, visuospatial sketchpad, and phonological loop). T-test analyses showed that self-identified targets performed more poorly on the suite of tests compared to non-bullied counterparts, primarily driven by deficits in central executive functioning. Study 2 recruited 70 retail and hospitality workers who completed the cognitive tasks plus measures of preoccupying cognitions and exposure to negative acts. As hypothesised, we found significant indirect effects demonstrating that preoccupying cognitions explained the negative relationship between bullying and the three aspects of working memory. The magnitude of the cognitive deficits observed here, and their potential significance for job performance, highlights the importance of primary bullying prevention within organisations. Secondary and tertiary prevention efforts should also consider cognitive impairments experienced by targets and look for opportunities to reduce preoccupying cognitions, which compete for limited cognitive resources, to mitigate the erosive effects of bullying. [ABSTRACT FROM AUTHOR]

Background: White matter hyperintensities (WMHs) are often measured globally, but spatial patterns of WMHs could underlie different risk factors and neuropathological and clinical correlates. We investigated the spatial heterogeneity of WMHs and their association with comorbidities, Alzheimer's disease (AD) risk factors, and cognition. Methods: In this cross-sectional study, we studied 171 cognitively unimpaired (CU; median age: 65 years, range: 50 to 89) and 51 mildly cognitively impaired (MCI; median age: 72, range: 53 to 89) individuals with available amyloid (18F-flutementamol) PET and FLAIR-weighted images. Comorbidities were assessed using the Cumulative Illness Rating Scale (CIRS). Each participant's white matter was segmented into 38 parcels, and WMH volume was calculated in each parcel. Correlated principal component analysis was applied to the parceled WMH data to determine patterns of WMH covariation. Adjusted and unadjusted linear regression models were used to investigate associations of component scores with comorbidities and AD-related factors. Using multiple linear regression, we tested whether WMH component scores predicted cognitive performance. Results: Principal component analysis identified four WMH components that broadly describe FLAIR signal hyperintensities in posterior, periventricular, and deep white matter regions, as well as basal ganglia and thalamic structures. In CU individuals, hypertension was associated with all patterns except the periventricular component. MCI individuals showed more diverse associations. The posterior and deep components were associated with renal disorders, the periventricular component was associated with increased amyloid, and the subcortical gray matter structures was associated with sleep disorders, endocrine/metabolic disorders, and increased amyloid. In the combined sample (CU + MCI), the main effects of WMH components were not associated with cognition but predicted poorer episodic memory performance in the presence of increased amyloid. No interaction between hypertension and the number of comorbidities on component scores was observed. Conclusion: Our study underscores the significance of understanding the regional distribution patterns of WMHs and the valuable insights that risk factors can offer regarding their underlying causes. Moreover, patterns of hyperintensities in periventricular regions and deep gray matter structures may have more pronounced cognitive implications, especially when amyloid pathology is also present. [ABSTRACT FROM AUTHOR]

Objective: Mindfulness programs and transcranial direct current stimulation (tDCS), particularly of the dorsolateral prefrontal cortex (DLPFC), are increasingly used for therapeutic purposes in Attention Deficit Hyperactivity Disorder (ADHD). The aim of the present study was to investigate the effect of DLPFC stimulation compared to mindfulness exercises on cognitive performance in children with ADHD. Materials and Methods: In this quasi-experimental study, 45 children with ADHD participated in a between-group design (mindfulness program, DLPFC stimulation, and sham stimulation) with two measurement phases (pre-test and post-test). All subjects underwent 15 intervention sessions according to their respective group. At various stages, participants were tested on cognitive flexibility (Wisconsin Card Sorting Test) and working memory (Wechsler Intelligence Scale). Findings: The results of the composite analysis of variance showed significant main effects of time, group, and the time-group interaction for the research variables, including cognitive flexibility (perseverative error and total error) and working memory. Post hoc test results indicated that the DLPFC stimulation group had significantly better scores in cognitive flexibility (perseverative error and total error) and working memory compared to the mindfulness group. Conclusion: Hypoactivity of the dorsolateral prefrontal cortex underlies executive function deficits in individuals with ADHD, and transcranial direct current stimulation increases activation of the dorsolateral prefrontal cortex through anodal stimulation. [ABSTRACT FROM AUTHOR]

A pervasive environmental stressor is one that damages mental and physical health as well as cognitive abilities by producing noise at a specific frequency and level. Current noise pollution levels pose a significant threat to public health, potentially leading to impaired cognitive function, increased stress, and other negative health consequences. This study aims to investigate the relationship between noise exposure and human cognitive abilities using a comprehensive analysis of power spectrum density (PSD) derived from EEG signals. Twenty-four participants completed the experiment to identify the effect of exposure to different noise levels (55 dB, 65 dB, 70 dB, 75 dB, 80 dB, and 85 dB) and two types of continuous and intermittent noise. The Stroop Color–Word Test and the Emotive Epoch EEG are cognitive task instruments used during experiments. Behavioral performance (accuracy and response time) and power spectrum electroencephalographic density were collected and analyzed. The methodology involved collecting EEG data from participants exposed to controlled noise stimuli and a subsequent PSD analysis to uncover frequency-specific patterns associated with cognitive processes. Attention levels were measured by examining beta wave activity, while stress responses were evaluated through an alpha wave analysis. Additionally, mental workload was assessed by considering the overall distribution of PSD through the theta-to-alpha ratio. The results revealed a significant relationship between the exposure to noise types and levels and human cognitive ability. The analysis of the power spectrum density on the cognitive aspects of attention and stress yielded results indicating that participants were in the best attention condition and in a relaxed or unstressed state when exposed to noise levels of 65 dB in both continuous and intermittent noise types. For the mental workload aspect, participants exposed to both continuous and intermittent noise types at a noise level of 70 dB began to indicate the presence of mental workload. These findings supported the importance of considering the impact of environmental noise on human cognitive well-being and demonstrated the potential of EEG monitoring as an objective tool for assessing the impact of noise on cognitive performance. [ABSTRACT FROM AUTHOR]

Many studies suggest a significant association between individual essential trace elements (ETEs) and cognitive impairment in older adults, but evidence of the synchronized effect of multiple ETEs on cognitive function is lacking. We investigated the association between multiple ETEs, cognitive impairment with no dementia (CIND), and executive function in older Korean adults, using the Bayesian kernel machine regression (BKMR) model. Three hundred and thirty-six older adults were included as the study population and classified as the CIND and control groups. Blood manganese (Mn), copper (Cu), zinc (Zn), selenium (Se), and molybdenum (Mo) were measured as relevant ETEs. The frontal/executive tests included digit symbol coding (DSC), the Korean color word Stroop test (K-CWST), a controlled oral word association test (COWAT), and a trial-making test (TMT). Overall, the BKMR showed a negative association between multiple ETEs and the odds of CIND. Mn was designated as the most dominant element associated with the CIND (PIP = 0.6184), with a U-shaped relationship. Cu and Se levels were positively associated with the K-CWST percentiles (β = 31.78; 95% CI: 13.51, 50.06) and DSC percentiles (β = 25.10; 95% CI: 7.66, 42.53), respectively. Our results suggest that exposure to multiple ETEs may be linked to a protective mechanism against cognitive impairment in older adults. [ABSTRACT FROM AUTHOR]

The natural light environment in polar regions is different in that there are midnight sun and polar night rather than a regular year-round alternation of day and night. Existing research has reported that the scientific modulation of interior light parameters can reduce the negative effects on the circadian rhythm and improve brain functions of the staff members at polar stations, from basic physiological mechanisms to higher cognitive functions, such as perception, learning, memory, and thinking. Currently, the appropriate balance of visual and nonvisual aspects that allow lighting conditions to be applied in a manner conducive to human well-being, health and functioning is still to be investigated, and accurate analysis of the influence rules of functional lighting's vertical illuminance at eye level on cognitive performance remains an unresolved and important issue. This study analyses the effects of the vertical illuminance at eye level of functional lighting on the cognitive performance indicators toward the target population through simple reaction time task, cancellation test, and stroop test, and concludes that vertical illuminance levels of 260 ~ 300 lx at eye level contributed to improved cognitive performance. The study also verifies that comfort and satisfaction indices of subjective perceptions are significantly and strongly correlated with cognitive function indicators, and slightly better than the relaxation index. However, the attention index is not significantly correlated with cognitive function indicators. This study can provide data reference for the light design and operational decisions of buildings in Antarctica and the Arctic to promote wider application and impact. [ABSTRACT FROM AUTHOR]

INTRODUCTION: Sleep inertia is the transition state during which alertness and cognitive performance are temporarily impaired after awakening. Magnitude and time course of sleep inertia are characterized by high individual variability with large differences between the cognitive functions affected. This period of impairment is of concern to pilots, who take sleep or nap periods during on-call work hours or in-flight rest, then need to perform safety-critical tasks soon after waking. This review analyzes literature related to sleep inertia and countermeasures applicable for aviation. METHODS: The large part of scientific literature that focuses on sleep inertia is based on studies in patients with chronic sleep inertia. We analyzed 8 narrative reviews and 64 papers related to acute sleep inertia in healthy subjects. DISCUSSION: Sleep inertia is a multifactorial, complex process, and many different protocols have been conducted, with a low number of subjects, in noncontrolled laboratory designs, with questionnaires or cognitive tests that have not been replicated. Evidence suggests that waking after sleep loss, or from deeper stages of sleep, can exacerbate sleep inertia through complex interactions between awakening and sleep-promoting brain structures. Nevertheless, no meta-analyses are possible and extrapolation to pilots’ performances is hypothetical. Studies in real life or simulated operational situations must be conducted to improve the description of the impact of sleep inertia and kinetics on pilots’ performances. Taking rest or sleep time remains the main method for pilots to fight against fatigue and related decreases in performance. We propose proactive strategies to mitigate sleep inertia and improve alertness. [ABSTRACT FROM AUTHOR]