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918 results on '"Campieri, M."'

102. Interleukin 1 beta (IL-1 beta) release from fresh and cultured colonic mucosa in patients with ulcerative colitis (UC)

Author

Gionchetti, P, Campieri, M, Belluzzi, A, Tampieri, M, Bertinelli, E, Brignola, C, Ferretti, M, Boni, P, Iannone, P, Miglioli, M, Gionchetti, P, Campieri, M, Belluzzi, A, Tampieri, M, Bertinelli, E, Brignola, C, Ferretti, M, Boni, P, Iannone, P, and Miglioli, M

Subjects
Adult, Male, Colon, Humans, Colitis, Ulcerative, Enzyme-Linked Immunosorbent Assay, Female, Intestinal Mucosa, Cells, Cultured, Human, Interleukin-1
Abstract

Interleukin-1, a cytokine produced by macrophages and other tissue cells, has a major role in inflammatory and immunological responses. Increased levels of IL-1 activity have been reported in experimental colitis and in patients with active Crohn's disease (CD) and ulcerative colitis (UC). IL-1 beta release from fresh and cultured colonic biopsies and IL-1 beta plasma concentrations was determined in 15 patients with active UC, 16 with UC in remission and 10 normal control subjects. Biopsies, taken at colonoscopy were weighed, washed in 1 ml of 0.9% sodium chloride solution and then cultured for 24 h in 10% fetal calf serum/RPMI. IL-1 beta activity was determined by ELISA KIT (Cystron Biotechnology) in plasma samples, washing solution and the incubation medium. Very low levels of IL-1 beta were detected only in 3 plasma samples, all from active patients. Significantly more IL-1 beta was released from fresh and cultured colonic mucosa obtained from patients with UC in remission compared to normal mucosa (p less than 0.01). Furthermore, specimens from active UC released significantly more IL-1 beta than those from patients in remission (p less than 0.01). In conclusion, IL-1 may play an important role in mediating the inflammatory response in UC.

Published
1992

110. Randomized Controlled Trials in Pouchitis

Author

Gionchetti, P., primary, Calafiore, A., additional, Pratico, C., additional, Laureti, S., additional, Vitali, G., additional, Poggioli, G., additional, Campieri, M., additional, and Rizzello, F., additional

Published
2012
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111. New insights into the brain involvement in patients with Crohn’s disease: a voxel‐based morphometry study

Author

Agostini, A., primary, Benuzzi, F., additional, Filippini, N., additional, Bertani, A., additional, Scarcelli, A., additional, Farinelli, V., additional, Marchetta, C., additional, Calabrese, C., additional, Rizzello, F., additional, Gionchetti, P., additional, Ercolani, M., additional, Campieri, M., additional, and Nichelli, P., additional

Published
2012
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135. Which therapies are advisable in pouchitis?

Author

Gionchetti, P., primary, Rizzello, F., additional, Tambasco, R., additional, Straforini, G., additional, Poggioli, G., additional, Calabrese, C., additional, Brugnera, R., additional, and Campieri, M., additional

Published
2008
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141. DNA derived from probiotic bacteria modulates human dendritic cell phenotype and function

Author

Lammers, K.M., Hart, A.L., Brigidi, P., Vitali, B., Rizzello, F., Gionchetti, P., Campieri, M., Kamm, M.A., Knight, S.C., and Stagg, A.J.

Subjects
Research, Risk factors, Health aspects, Thermophiles -- Risk factors -- Research -- Health aspects, Dendritic cells -- Health aspects -- Research, Probiotics -- Research -- Health aspects, Bacteria, Thermophilic -- Risk factors -- Research -- Health aspects
Abstract

Introduction: Unmethylated CpG motifs, predominantly present in bacterial DNA, can be immunostimulatory via toll-like receptor (TLR)-9. Commensal bacteria play a role in maintaining immune homeostasis in the gut. Dendritic cells [...]

Published
2004

143. Recognition of bactericidal/permeability-increasing protein by perinuclear anti-neutrophil cytoplasmic antibody-positive sera from ulcerative colitis patients: prevalence and clinical significance

Author

Vecchi, M, Sinico, R, Bianchi, M, Radice, A, Gionchetti, P, Campieri, M, de Franchis, R, de Franchis, R., SINICO, RENATO ALBERTO, Vecchi, M, Sinico, R, Bianchi, M, Radice, A, Gionchetti, P, Campieri, M, de Franchis, R, de Franchis, R., and SINICO, RENATO ALBERTO

Abstract

Background: The aim of this study was to evaluate a) the role of bactericidal/permeability-increasing protein (BPI) as a possible antigen determining perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) reactivity in ulcerative colitis and b) the prevalence and clinical correlates of anti-BPI antibodies in patients with ulcerative colitis on the basis of their p-ANCA status. Methods: p-ANCA and anti-BPI antibodies were evaluated by means of indirect immunofluorescence and enzyme-linked immunosorbent assay methods in a group of 112 ulcerative colitis patients (including 42 patients subjected to proctocolectomy) well defined as far as their clinical features and p-ANCA status. Results: Anti-BPI antibodies were detected in 24% of non-operated patients and were significantly more frequent in p-ANCA-positive patients (32% versus 5% in p-ANCA-negative patients; P < 0.015). The prevalence of anti-BPI antibodies was similar in non-operated and operated patients and was high in men, in patients with an extensive and aggressive disease, and in patients developing pouchitis after surgery. Conclusions: These data indicate that BPI is a neutrophil antigen frequently recognized by p-ANCA-positive ulcerative colitis sera. The presence of anti- BPI antibodies appears to identify further immunologic and clinical heterogeneity in ulcerative colitis

Published
1998

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