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In order to achieve the goal of “double carbon” as soon as possible, SF6 substitute gas is more environmentally friendly and applied in electrical equipment. Based on density functional theory (DFT), the ionization energy, polarizability and HOMO-LUMO energy level of the SF6 substitute gas were calculated. First, some relevant electrical parameters representing the substitute gas were linearly fitted to their experimental values. Secondly, the prediction simulation equation of the relative electric strength of the substitute gas is obtained by multivariate nonlinear fitting, and then the prediction results are screened. Finally, the relationship between the electrical parameters of the surrogate gas molecule and the relationship between the relative molecular mass under the external electric field is further studied. The research results show that the ionization energy, average electron polarizability and HOMO-LUMO energy level of substitute gas molecules have a strong positive correlation with their relative electric strength, and HFO-type substitute gases can be used as SF6 substitute gases. Under the external electric field, the ionization energy and HOMO-LUMO level of the surrogate gas molecules decrease with the increase of the gas molecular mass, and the average electron polarizability increases with the increase of the gas molecular mass. For the screening of alternative gases, the carbon chain should be selected to be shorter, the relative molecular mass is more significant, and the average molecular weight is higher. The fluoride of the electron polarizability functional group provides a more precise direction for screening SF6 substitute gases and has a particular guiding significance.

IntroductionPlant richness is thought to improve the function of constructed wetlands (CWs), but most CWs are planted with monocultures, with only a few employed polycultures, which have drawn contradictory conclusions. We suppose functional diversity is the key to better performance of plant communities and hypothesize that CWs planted with diverse growth forms are superior in plant growth and nutrient removal.MethodsIn this study, six emergent plant species categorized into slender type (Schoenoplectus tabernaemontani, Typha orientalis), fan type (Iris sibirica, Acorus calamus) and large type (Canna indica and Thalia dealbata) were planted in monocultures, combinations (two species of the same growth form) and mixed polycultures (six species of three growth forms). We then compared how plant growth and nutrient uptake differed among treatments.ResultsIt showed that the polyculture considerably increased the removal of total nitrogen (TN) and total phosphorus (TP), but the combination did not outperform monoculture. High consistency in the patterns between underground biomass and total biomass indicated that plant roots were essential for nutrient consumption. Compared with slender and fan plants, the large plants had a greater biomass increase in polycultures, which greatly accelerated the absorption and assimilation of TN and TP.ConclusionOur study indicated that plant community with various growth forms reduced the intensity of interspecific competition, increased the functional diversity, and greatly enhanced the ability of pollutant removal. Our results also provide some suggestions for plant selection and combination designs in CWs.

Abstract Targeting CD96 that originates in immune cells has shown potential for cancer therapy. However, the role of intrinsic CD96 in solid tumor cells remains unknown. Here, it is found that CD96 is frequently expressed in tumor cells from clinical breast cancer samples and is correlated with poor long‐term prognosis in these patients. The CD96+ cancer cell subpopulations exhibit features of both breast cancer stem cells and chemoresistance. In vivo inhibition of cancer cell‐intrinsic CD96 enhances the chemotherapeutic response in a patient‐derived tumor xenograft model. Mechanistically, CD96 enhances mitochondrial fatty acid β‐oxidation via the CD155‐CD96‐Src‐Stat3‐Opa1 pathway, which subsequently promotes chemoresistance in breast cancer stem cells. A previously unknown role is identified for tumor cell‐intrinsic CD96 and an attractive target in improving the chemotherapeutic response.

Premenstrual syndrome (PMS), a recurrent and moderate disorder that occurs during the luteal phase of the menstrual cycle and quickly resolves after menstruation, is characterized by somatic and emotional discomfort that can be severe enough to impair daily activities. Current therapeutic drugs for PMS such as selective serotonin reuptake inhibitors are not very satisfying. As a critical pineal hormone, melatonin has increasingly been suggested to modulate PMS symptoms. In this review, we update the latest progress on PMS-induced sleep disturbance, mood changes, and cognitive impairment and provide possible pathways by which melatonin attenuates these symptoms. Moreover, we focus on the role of melatonin in PMS molecular mechanisms. Herein, we show that melatonin can regulate ovarian estrogen and progesterone, of which cyclic fluctuations contribute to PMS pathogenesis. Melatonin also modulates gamma-aminobutyric acid and the brain-derived neurotrophic factor system in PMS. Interpreting the role of melatonin in PMS is not only informative to clarify PMS etiology but also instructive to melatonin and its receptor agonist application to promote female health. As a safe interaction, melatonin treatment can be effective in alleviating symptoms of PMS. However, symptoms such as sleep disturbance, depressive mood, cognitive impairment are not specific and can be easily misdiagnosed. Connections between melatonin receptor, ovarian steroid dysfunction, and PMS are not consistent among past studies. Before final conclusions are drawn, more well-organized and rigorous studies are recommended.

Cellulose insulation paper is an essential part of the transformer oil-paper insulation system, and many types of nano-modified insulating paper are available. For studying the effects of various nano-modified molecules on cellulose and the differences in performance, the pure cellulose model and polyoctaaminophenylsesquioxane and grafted 3-aminopropyltriethoxysilane (KH550) SiO2 and Al2O3 cellulose models were developed using molecular dynamics methods, and the mechanical properties and thermally stability were calculated and compared. The findings show that, in general, all three nano-modification models improved the thermal stability and mechanical properties, with nano-SiO2-KH550 cellulose having the best overall modification effect. In terms of mechanical properties, the nano-SiO2-KH550 cellulose showed the largest increase in compressive strength, with an 18.1% improvement. In terms of thermal stability, the KH550 grafted nano-silica/cellulose composite model showed the best modification effect, as evidenced by the smaller cohesive energy density and free volume region compressing the space between cellulose molecules, making the modified cellulose more compact internally, thus achieving the effect of inhibiting the movement of cellulose chains.

Oxyhalides, containing oxygen and halogen atoms and combining the advantages of oxides and halides in geometry and optical response, have great potential in optical materials. In this study, the electronic structures and the optical properties of the Pb3O2X2 (X = Cl, Br, I) compounds have been investigated using the first principles method. The results show that these compounds have birefringence at 0.076, 0.078, and 0.059 @ 1064 nm, respectively. And, the asymmetric stereochemical active lone pair electrons were found around lead atoms, which were confirmed by the projected density of states, the electronic localization functions, and the crystal orbitals. The contribution of atoms and polyhedra to birefringence was further evaluated using the Born effective charge. The results show that halogen atoms give negative contribution, and lead—oxygen polyhedra give positive contribution. The spin—orbit coupling effect is also investigated, and the downshift of the conduction band and variation in the valence band are found after relevant spin—orbit coupling (SOC), which leads to a reduction in the band gap and birefringence.

At present, electrified railroads with complex road conditions are facing the problems of the existence of a single power supply method, the deterioration in power quality, and the difficulty in recycling regenerative braking energy. In order to improve the above problems, this paper establishes a traction power supply system containing photovoltaic units, proposes an optimized compensation model for the RPC (railroad power conditioner), and improves the particle swarm algorithm for solving the reference value of RPC compensation power. First, the structure of the RPC-based traction photovoltaic power generation system and the establishment of the integrated energy management strategy of the system are constructed. Then, the back-to-back converter compensation model with power quality index parameter constraints is established, which establishes the optimization function with the objectives of minimizing the negative sequence current, maximizing the power factor, and minimizing the RPC compensation power, as well as establishes constraints on the active converter capacity and three-phase voltage imbalance. Then, the particle swarm algorithm for solving the RPC compensation power reference value is improved, specifically in the original PSO by introducing dynamically changing inertia weights and learning factors. This not only solves the problem of the single power supply and realizes the nearby consumption of photovoltaic units in the traction system, but also realizes the recycling of regenerative braking energy and the coordinated control of the traction photovoltaic power generation system, improves the power quality of the system, and meets the demand of the RPC for real-time control. In order to verify the effectiveness of the optimized compensation model established in this paper and improve the convergence of the particle swarm algorithm for solving the RPC compensation power reference value, a simulation model of the traction PV power generation system is established in MATLAB/Simulink, and a real-time simulation is carried out to verify it based on the preset working condition data. The results show that the RPC optimization compensation model developed in this paper can coordinate the control system energy flow and improve the system power quality (the power factor increases and the negative sequence current decreases). The improved particle swarm algorithm is more convergent.

Introduction:This study aimed to evaluate the neuroimaging results and associated characteristics of patients admitted to a pediatric emergency department for their first afebrile seizures.Methods:Patients admitted to the Emergency Room of University of Health Sciences Turkey, Ankara Dr. Sami Ulus Children’s Hospital between January 1, 2016 and December 31, 2019, with a diagnosis of first afebrile seizure were included in this study. Patients in this study included children without prior neurological or chronic disease and no history of drug use. The medical files of the patients were examined retrospectively.Results:In our study group, 55% were male (n=22) and 45% were female (n=18). The median age was 4.50 (0.25-17.00) years. The median seizure duration was 5.0 (0.03-30.0) minutes. Physical examinations performed in the emergency department yielded unremarkable findings in 80% (n=32) of the patients. A computed tomography scan detected a specific pathology in 10% (n=4) of the patients and magnetic resonance imaging was used in 12.5% (n=5) of the patients. There was no significant difference in terms of gender, age, and seizure duration between patients with and without pathology detected in neuroimaging (p>0.05).Conclusion:On evaluating patients admitted to the emergency department with their first afebrile seizures, 85% had normal neuroimaging findings. Variables such as gender, age, and seizure duration were not associated with the presence or absence of pathology in neuroimaging.

Intravesical instillation of Bacillus Calmette-Guérin has been used as an immunotherapy to treat superficial bladder cancer for almost half a century. In recent years, the approval of several monoclonal antibody treatments has transformed the treatment landscape for patients with muscle-invasive or metastatic uroepithelial carcinoma. The purpose of this study was to conduct a thorough review of immunotherapy in bladder cancer through a bibliometric approach. Publications related to bladder cancer immunotherapy were obtained from the Web of Science Core Collection on July 1st, 2022. We conducted a bibliometric analysis of literature information using CiteSpace IV, VOSviewer, and Scimago Graphica, including co-authorship or co-citation of authors, countries/regions, journals, references, and keyword co-occurrence. There was a total of 2,352 papers included, with the most contributions coming from the United States, China, and Italy. The United States had the highest H-index value and was the leading country in this field. Meanwhile, the number of publications in China was steadily growing. The top three productive researchers were Kamat AM, Necchi A, and Shariat SF, with Powles T as the top co-cited author. Most papers were published by the University of Texas System. The majority of papers in this field were published in Urologic Oncology Seminars and Original Investigations and European Urology was the most influential journal with the highest H-index. The tumor microenvironment and complete molecular characterization may still be the frontier in this research area, allowing us to obtain a better understanding of the pathogenesis and clinical prognosis of bladder cancer. More research are conducted to identify clinically meaningful biomarkers that may provide opportunities for the personalization of bladder cancer therapy. This study provides clinicians and researchers with an overview and helpful guidance on how to choose the research direction and management of bladder cancer immunotherapy.

The endless struggle between two seemingly incompatible but occasionally convergent concepts, namely liberal values and national interests, has determined United States (US) foreign policy and its implementation throughout the nation’s history. Based on the neoclassical realist assumptions shored up by the methodological insights offered by the five-dimensional pre-theory of foreign policy, this article reveals a persistent dichotomy in US foreign policy through the analysis of Washington’s response to the Arab Spring uprisings in Egypt, Libya, and Syria. Throughout history, US foreign policy has had a pendular behavioral pattern, swinging across a policy spectrum ranging from moralpolitik to realpolitik. While the inherent values-interests dilemma lies at the root of the inveterate oscillation of US foreign policy, the interplay of international stimulus and societal factors stands out as the principal source of its ambivalence, if not inconsistency, in the face of the upheavals that swept across the Middle East.

Background Sagittaria trifolia Linn. is a widespread macrophyte in Asia and southeast Europe and cultivated in parts of Asia. Although a few genomic studies have been conducted for S. trifolia var. sinensis, a crop breed, there is limited genomic information on the wild species of S. trifolia. Effective microsatellite markers are also lacking. Objective To assemble transcriptome sequence and develop effective EST-SSR markers for S. trifolia. Methods Here we developed microsatellite markers based on tri-, tetra-, penta-, and hexa-nucleotide repeat sequences by comparatively screening multiple transcriptome sequences of eleven individuals from ten natural populations of S. trifolia. Results A total of 107,022 unigenes were de novo assembled, with a mean length of 730 bp and an N50 length of 1,378 bp. The main repeat types were mononucleotide, trinucleotide, and dinucleotide, accounting for 55.83%, 23.51%, and 17.56% of the total repeats, respectively. A total of 86 microsatellite loci were identified with repeats of tri-, tetra-, penta-, and hexa-nucleotide. For SSR verification, 28 polymorphic loci from 41 randomly picked markers were found to produce stable and polymorphic bands, with the number of alleles per locus ranging from 2 to 11 and a mean of 5.2. The range of polymorphic information content (PIC) of each SSR locus varied from 0.25 to 0.80, with an average of 0.58. The expected heterozygosity ranged from 0.29 to 0.82, whereas the observed heterozygosity ranged from 0.25 to 0.90. Conclusion The assembled transcriptome and annotated unigenes of S. trifolia provide a basis for future studies on gene functions, pathways, and molecular mechanisms associated with this species and other related. The newly developed EST-SSR markers could be effective in examining population genetic structure, differentiation, and parentage analyses in ecological and evolutionary studies of S. trifolia.

The thermal expansion behavior, microstructure evolution and β → ωiso phase transformation kinetics of the low cost Ti–3Al–5Mo–4Cr–2Zr–1Fe (Ti-35421, wt.%) titanium alloy during continuous heating have been investigated by using dilatometric (DIL) method. The results revealed that corresponding transformation sequence can be verified as β → ωiso, β + ωiso → α + β, β → α and α → β using TEM and SEM analysis during the heating process. The microstructure and local composition distribution was detected by STEM mapping. The phase transition curve exhibited a typical S-type pattern, indicating the phase transformation was controlled by the nucleation and growth mechanism. It was found that the S-curve shifted to a higher temperature and the phase transition interval became shorter as the heating rate increased. Furthermore, the average activation energy required for the β → ωiso phase transition was calculated by Kissinger–Akahira–Sunose (KAS) equation is about 90.21 kJ/mol. The Avrami exponent n in the Kolmogorov–Johnson–Mehl–Avrami (KJMA) model was used to study the nucleation growth mechanism of the ω phase during continuous heating. The exponent n can be divided into three stages: the initial phase transition (0.02

Tedavi reddi çocuk acil servislerinde hekim ve hasta için önemli bir sağlık sorunudur. Hastalar acil tıbbi tedaviyi herhangi bir zamanda reddedebilir. Bu çalışmada çocuk acil servise başvuran ebeveynlerin çocuklarının tedavisini reddetme nedenlerinin belirlenmesi amaçlanmıştır. Sağlık Bilimleri Üniversitesi Dr Sami Ulus Kadın Doğum Çocuk Sağlığı ve Hastalıkları Eğitim Araştırma Hastanesi Çocuk Acil Kliniği’ne 2016 - 2018 yılları arasında başvuran ve ebeveynlerinin tedaviyi reddettiği hastaların verileri red formları ve elektronik kayıtları incelenerek geriye dönük incelendi.İki yıllık dönemde çocuk acil kliğine 207.494 hasta başvurusundan 118 (%0,05) hastanın ebeveyni tedaviyi reddetmiştir. Hastaların tanıları sıklık sırasıyla; alt solunum yolu enfeksiyonu 46 (%39), akut odağı olmayan ateş 14 (%11.9), beşer hasta ilaç zehirlenmesi ve akut gastroenterit idi. Hastaların 71’i (%60.2) tedaviye evde devam etmek için, 24’ü (%20.3) takip ve tedaviyi başka merkezde yaptırmak istediği için tedaviyi reddetmiştir. 16 (%13.5) hasta lomber ponksiyon girişimini kabul etmeyerek tedaviyi reddetti. Çocuk acil servise 2 yıllık sürede başvuran hastaların %0,05 tedaviyi reddetmiştir. En sık tedavi reddi nedenleri; ailelerin tedaviyi evde veya başka merkezlerde devam etmek istemesi ve girişimsel işlemler ile ilgili olası yan etkilerin ailelerde korkulara neden olup, hastada ağrı olasılığı nedeniyle tedaviyi reddetme karar vermesi olarak görülmektedir.

Introduction:In this study, we aimed to reveal the demographic data and the trauma characteristics of the patients with orthopedic trauma, which is common in childhood.Methods:In our study, 117 forensic cases aged 0-18 years, who applied to the Pediatric Emergency Department of University of Health Sciences Turkey, Tepecik Training and Research Hospital between 01.01.2016 and 31.12.2016, were consulted to the orthopedics and traumatology. The demographic characteristics of the patients, the way of applying to the emergency service, the type of trauma, the characteristics of the injury that occurred, additional consultations required from other clinics, radiological imagings other than direct radiography, and hospitalization of the patients were evaluated.Results:35.9% (n=42) of the patients included in our study were girls and the average age of girls were 9.09 (±6.04) years, and the average age of boys were 11.82 (±5.05) years. It was observed that the most common injury region was upper limbs with 52.1%. There was an increase in the number of blunt traumas, penetrating device injuries and gunshot injuries at older ages. It was observed that 45.3% (n=53) of the patients were consulted to other clinics besides the orthopedics and traumatology. When the patients were consulted, it was seen that they were consulted predominantly for surgical branches, especially neurosurgery (n=38, 32.4%) and pediatric surgery (n=28, 23.9%).Conclusion:In the majority of the forensic cases in children age group who are in need of orthopedics and traumatology consultation in the emergency department, injury occurs as a result of falling from height. Especially after the age of 14 years, it was seen that blunt trauma and sharp object injuries came into prominence in forensic cases related to orthopedics and traumatology clinic.

Objective: This study has investigated the amount of bone remodeling in patients with a slipped capital femoral epiphysis (SCFE) treated with in situ fixation until closure of the epiphysis and the factors affecting remodeling. Method: Patients who underwent surgery for SCFE between January 2010 and January 2015 were retrospectively screened: Twenty-four male and 7 female patients (mean age 12.6 +- 1.9 years) were included in the study. Gender, age, history, and laterality of trauma, duration of hip pain (acute, chronic, acute on chronic background), and hip radiographs were evaluated. The Southwick and alpha angles were measured, and the factors affecting remodeling were assessed. The statistical analyses were conducted using SPSS 25.0 (IBM Corp., Armonk, NY); 95% confidence levels were calculated and p < 0.05 was considered to indicate statistical significance. Results: The preoperative displacement angles measured on the anteroposterior and lateral radiographs were 15.03° +- 9.1° and 25.93° +- 14.1° and at the last follow-up they were 11.63° +- 8.7° and 21.6° +- 12.1°, respectively. The alpha angles measured on the lateral radiographs preoperatively and at the end of follow-up were 52.33° +- 11.6° and 47.87° +- 11.8°, respectively. Significant remodeling was reflected in the angles measured on the anteroposterior and lateral X-ray images. Greater preoperative displacement angle was associated with less remodeling. Conclusion: Preoperative displacement affects the degree of postoperative remodeling. In patients with severe epiphyseal displacement, open reduction is an option but in situ pinning should be considered in that it is less invasive and more physiological.

Welwitschia mirabilis is a unique plant that only has two leaves, but it can survive in hostile conditions of the African desert. Here, the authors report its chromosome-level genome assembly and discuss how gene function and regulation have given rise to its unique morphology and environmental adaptions.

Salinity stress (SS) is a serious abiotic stress and a major constraint to agricultural productivity across the globe. High SS negatively affects plant growth and yield by altering soil physio-chemical properties and plant physiological, biochemical, and molecular processes. The application of micronutrients is considered an important practice to mitigate the adverse effects of SS. Zinc (Zn) is an important nutrient that plays an imperative role in plant growth, and it could also help alleviate the effects of salt stress. Zn application improves seed germination, seedling growth, water uptake, plant water relations, nutrient uptake, and nutrient homeostasis, therefore improving plant performance and saline conditions. Zn application also protects the photosynthetic apparatus from salinity-induced oxidative stress and improves stomata movement, chlorophyll synthesis, carbon fixation, and osmolytes and hormone accumulation. Moreover, Zn application also increases the synthesis of secondary metabolites and the expression of stress responsive genes and stimulates antioxidant activities to counter the toxic effects of salt stress. Therefore, to better understand the role of Zn in plants under SS, we have discussed the various mechanisms by which Zn induces salinity tolerance in plants. We have also identified diverse research gaps that must be filled in future research programs. The present review article will fill the knowledge gaps on the role of Zn in mitigating salinity stress. This review will also help readers to learn more about the role of Zn and will provide new suggestions on how this knowledge can be used to develop salt tolerance in plants by using Zn.

This article primarily investigates nonlinear disturbance observer-based bearing-only formation tracking control for unmanned aerial vehicle (UAV) systems that encounter uncertainties and disturbances. The employed distributed control strategy relies solely on the relative bearing information of neighboring UAVs. To tackle the challenges posed by unknown disturbances and system uncertainties, a novel nonlinear disturbance observer is proposed to effectively mitigate their impact. Moreover, the issue of unknown controller orientation arising from controller singularities is addressed by introducing a Butterworth low-pass filter. This filter ensures a consistent controller gain and enhances disturbance suppression, ultimately transforming the controller gain function into a constant value of 1. Subsequently, a bearing-only formation tracking controller is developed using the backstepping control approach. The stability of the closed-loop control systems is rigorously proven using Lyapunov theory. Finally, numerical simulations are conducted to validate the effectiveness of the proposed scheme in achieving formation control objectives.

The converter valve is the core equipment of flexible DC transmission, but it has been severely damaged in previous earthquakes. Therefore, the seismic performance of its structure has a significant impact on the safety and reliability of power transmission. To study the seismic performance of ±500 kV flexible DC converter valves and identify weak links in the supporting valve tower, this article first established a refined finite-element model of a valve tower based on its physical structure; then modal analysis on the valve tower was conducted; finally, time-domain analysis of the valve tower under three seismic excitations, namely Wenchuan, EI Centro, and artificial, was conducted, and the equivalent stress and directional displacement cloud maps of the key parts of the valve tower were obtained. The research results indicate that the dynamic characteristics of the valve tower are relatively complex, with low fundamental frequency and diverse natural vibration modes. Under earthquake action, the predominant frequency of EI Centro waves is close to the fundamental frequency of the valve tower, which is prone to resonance and causes significant damage to the valve structure. The improved design of the valve tower meets the seismic strength requirements of level 8 seismic intensity.

Regarding the issue of individual purchasing behavior in the rapid growth of electric vehicles, this article studies the diffusion model of electric vehicles considering individual choices and social effects from the perspective of the scale and quantity changes of electric vehicles. First, the neural network was used to predict the charging data of electric vehicles, and the economic effects of purchasing electric vehicles were calculated by combining the purchase cost and government subsidies. Then, the utility function for owners to purchase electric or traditional fuel vehicles was created by considering economic effects, cognitive attitudes, and social effects as factors that individuals need to consider when purchasing electric or traditional fuel vehicles. Finally, the discrete choice model was used to calculate the probability of users choosing to purchase electric or traditional fuel vehicles, and the number of electric vehicles was statistically calculated. Analysis of simulation examples shows that the growth rate of fuel vehicles decreases year by year during the simulation period, and the trend of electric vehicle growth follows an S-curve.

Background: Ligneous cervicitis is a rarely reported disease in the literature, and it is commonly misdiagnosed as genital cancer. Patients with ligneous cervicitis can have multiple systemic problems. The lesions resemble malignancies. Multiple biopsies are essential for the diagnosis. Herein, we present 2 cases of ligneous cervicitis, both of which had plasminogen deficiency. Our aim in this report was to discuss these cases with guidance of the literature. Conclusion: Ligneous cervicitis commonly mimics female genital cancers. Hence, it is very important to utilize a multidisciplinary approach in making a differential diagnosis.

Objective:Upper gastrointestinal (GI) bleeding is a major reason of mortality and morbidity today, and patients’ follow-up and treatment costs are still high. In our study, the values of risk scorings of the patients with upper GI bleeding in estimation of mortality and morbidity were evaluated.Method:One hundred sixty-nine patients who were admitted to emergency internal medicine in University of Health Sciences Turkey, İstanbul Bağcılar Training and Research Hospital Clinic of Internal Medicine due to the diagnosis of upper GI bleeding were reviewed retrospectively between January 2015 and January 2016 in the study. Patients with upper GI bleeding due to varices (esophageal and gastric) endoscopically were excluded from the study. Forrest scoring’s classification was made according to the endoscopic findings. Classification of bleeding ulcers according to their appearance is as follows; Forrest 1a; ‘‘gushing active bleeding’’, Forrest 1b; ‘‘oozing active bleeding’’, Forrest 2a; ‘‘visible non-bleeding vein’’, Forrest 2b; ‘‘adherent clot’’, Forrest 2c; ‘‘flat pigmented lesion’’, Forrest 3; ‘‘no evidence of bleeding’’. Rockall scoring’s classification uses clinical criteria (pulse, age, systolic blood pressure, comorbidity) in addition to endoscopic findings (diagnosis, hemorrhage). Accordingly, a score less than 3 carries good prognosis. Glasgow-Blatchford scoring’s classification was calculated according to the situation of urea nitrogen, hemoglobin, systolic blood pressure, pulse, melena occurrence, syncope, and hepatic or cardiac problems. In this scoring, patients may be in the range of 0-23 points and the need for endoscopic intervention increases according to rising in the score.Results:The average age of the participants in the study was 57.39±19.14 years. 72% of the cases (n=121) were male. While the presence of melena was observed in 88.7% of the cases, it was seen that 61.9% of the cases had peptic ulcer and 12.5% of the general surgery consultation was performed. It was determined that there was no statistically significant difference in the Forrest classifications of the cases in terms of hospitalization duration and blood transfusion (p>0.05). Rockall and Glasgow-Blatchford scores were statistically remarkably higher in patients with hospitalization duration, need for blood transfusion, rebleeding, intensive care follow-up, surgical intervention, and mortality (p

To understand how spatial representations emerge and evolve across hippocampal subfields, we compared trial-to-trial dynamics of place cells in CA1 and CA3 in new environments and across days. CA1 place fields form early, shift backwards and partially remap across days whereas in CA3 they develop gradually and are more stable, suggesting distinct functional roles in representing space.

Birsen Can Demirdöğen,1 Yağmur Miçooğulları,2 Aysun Türkanoğlu Özçelik,3 Orhan Adalı4 1Department of Biomedical Engineering, TOBB University of Economics and Technology, Ankara, Turkey; 2Institute of Natural and Applied Sciences, Department of Biology, Middle East Technical University, Ankara, Turkey; 3Food Safety and Agricultural Research Center, Akdeniz University, Antalya, Turkey; 4Department of Biological Sciences, Joint Graduate Program in Biochemistry, Middle East Technical University, Ankara, TurkeyCorrespondence: Birsen Can DemirdöğenDepartment of Biomedical Engineering, TOBB University of Economics and Technology, Ankara, TurkeyTel +90 312 292 42 79Email birsencan.demirdogen@gmail.comPurpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury owing to their participation in the regulation of vascular tone and cerebral blood flow. In addition, mEH metabolizes polycyclic aromatic hydrocarbons, one of the causative factors of atherosclerotic lesion development. In this study, we aimed to investigate the association of enzyme activity-modifying missense single nucleotide polymorphisms (SNPs) of the sEH gene (EPHX2) and mEH gene (EPHX1) and ischemic stroke risk in a Turkish population.Patients and Methods: Genomic DNA of patients with large artery atherosclerotic ischemic stroke (n=237) and controls (n=120) was isolated from blood samples, and genotypes for Tyr113His (rs1051740) and His139Arg (rs2234922) SNPs of EPHX1 and Arg287Gln (rs751141) SNP of EPHX2 were attained by the PCR/RFLP method.Results: Minor allele frequency and genotype distributions for Arg287Gln, Tyr113His and His139Arg SNPs did not differ significantly between stroke patients and controls. However, hypertension- and diabetes-associated ischemic stroke risk was decreased by EPHX1 and increased by EPHX2 variants in stratification analyses.Conclusion: This study has shown for the first time that the polymorphic alleles of EPHX1 were unlikely to be associated with large artery atherosclerotic ischemic stroke susceptibility; however, protective effects were evident within subgroups of hypertension and diabetes. In addition, EPHX2 Arg287Gln polymorphism, which has been studied for the first time in a Turkish population, was not significantly related to ischemic stroke, but increased the stroke risk in subgroup analysis.Keywords: Arg287Gln, epoxyeicosatrienoic acids, EETs, His139Arg, SNP, Tyr113His

Background: Carcinosarcoma is a rare malignancy of the female reproductive system, consisting of carcinomatous and sarcomatous components. It originates from the paramesonephric and mesonephric duct residues and is also called malignant mixed Mullerian tumor. Case Presentation: A 58-year-old post-menopausal woman, gravida 2, parity 2, who had no known diseases and no previous surgery presented to another clinic with pelvic pain that had been persisting for about a year and vaginal bleeding for the past month. There was continuous bleeding that was not associated with coitus, and cervical biopsy was reported as carcinosarcoma of heterologous type (the epithelial part was serous carcinoma and the mesenchymal part was chondrosarcoma); the patient was referred to our clinic and underwent evaluation. Conclusion: Effective follow-up is very important considering the aggressive clinical picture of carcinosarcoma cases. It should be kept in mind that metastasis may occur, especially in cases with hypercalcemia and deterioration of the general condition.

Polyimide is often used as the insulating material of the repulsion coil, which needs to withstand the collision of the fast repulsion mechanism in high-speed motion and temperature rise. The polyimide molecular model was established in this study. The external electric field was applied to the model through the semi-empirical method to calculate the total molecular energy, dipole moment, molecular orbital energy, and energy gap of polyimide. It was found that the total molecular energy of plasma-modified polyimide was lower, the energy gap was smaller, and the corresponding molecular properties were more stable. Then, the cell models of ordinary polyimide and plasma-modified polyimide were established by molecular dynamics simulation. The effects of plasma modification on the micro properties of polyimide were studied and compared. The free volume, mean square displacement, cohesive energy density, mechanical properties, and relative dielectric constant of polyimide models with different modified ratios were calculated. The results show that the introduction of polar groups through plasma modification can inhibit the movement of the polyimide molecular chain and improve the thermal stability of the polyimide system. The mechanical properties of polyimide are also improved due to plasma modification, and the elastic modulus is the largest when the modification rate is 20%. At the same time, the relative dielectric constant of polyimide increases with the increase of the modification rate.

To achieve carbon neutrality in electricity, measures such as increasing the share of renewable energy sources such as wind power and achieving more accurate and faster wind power forecasting, and low carbon retrofitting of thermal power units are all important to achieve the goal. Firstly, the GRU prediction algorithm was used to forecast wind power, which performed well in terms of prediction accuracy and model training speed. Then, we continue to fully utilize the source-side low-carbon characteristics by installing flue gas bypass systems and liquid storage in carbon capture plants to form an integrated carbon capture plant operation, thereby reducing carbon emissions and the proportion of abandoned wind. Secondly, a three-stage low carbon economic dispatch model is established to reduce wind abandonment by combining wind power forecasts on different time scales. Finally, a case study was carried out using a modified IEEE-39 node system. The results show that the proposed three-stage integrated dispatching method can make full use of wind energy and achieve the goal of economic dispatching of the power system.

ObjectiveTo investigate the relationship between postoperative hypothalamo–hypophyseal injury (HHI) and postoperative water and sodium disturbances in patients with craniopharyngioma.MethodsThe medical records, radiological data, and laboratory results of 178 patients (44 children and 134 adults) who underwent microsurgery for craniopharyngioma in a single center were reviewed. Postoperative HHI was assessed using magnetic resonance imaging. Structural defects of the hypothalamo–hypophyseal system (pituitary, pituitary stalk, floor and lateral wall of the third ventricle) were assessed in four standard T1-weighted images. The defect of each structure was assigned 1 score (0.5 for the unilateral injury of the third ventricle wall), and a HHI score was calculated.ResultsThe number of patients with HHI scores of 0-1, 2, 2.5-3, and >3 was 35, 49, 61, and 33, respectively. Diabetes insipidus (DI) worsened in 56 (31.5%) patients with preoperative DI, while 119 (66.9%) patients were diagnosed with new-onset DI. Hypernatremia and hyponatremia developed in 127 (71.3%) and 128 (71.9%) patients after surgery, respectively. Syndrome of inappropriate antidiuresis occurred in 97(54.5%) patients. During hospitalization, hypernatremia recurred in 33 (18.5%) patients and in 54 (35.7%) during follow-up, of which 18 (11.9%) were severe. DI persisted in 140 (78.7%) patients before discharge. No relationship was found between the HHI score and incidence of early DI, hyponatremia, syndrome of inappropriate diuretic hormone, or prolonged DI. Compared with patients with a score of 0–1, those with scores =2.5-3 (OR = 5.289, 95% CI:1.098-25.477, P = 0.038) and >3 (OR = 10.815, 95% CI:2.148-54.457, P = 0.004) had higher risk of developing recurrent hypernatremia. Patients with a score >3 had higher risk of developing severe hypernatremia during hospitalization (OR = 15.487, 95% CI:1.852-129.539, P = 0.011) and at follow-up (OR = 28.637, 95% CI:3.060-267.981, P = 0.003).ConclusionsThe neuroimaging scoring scale is a simple tool to semi-quantify HHI after surgery. Recurrent and severe hypernatremia should be considered in patients with a high HHI score (>2.5). An HHI score >3 is a potential predictor of adipsic DI development. Preventive efforts should be implemented in the perioperative period to reduce the incidence of potentially catastrophic complications.

Zinc is an essential minor element for rice growth and human health, which can also change the structure of the microorganisms. However, it remains unclear for the effects of zinc fertilizer on microbiome function in agricultural soils and crops. To solve this research gap, we investigated the relationship between improving rice (Oryza sativa L.) yield, Zn concentration, soil microbial community diversity, and function by the application of Zn fertilizer. The field trials included three rice varieties (Huanghuazhan, Nanjing9108, and Nuodao-9925) and two soil Zn levels (0 and 30 kg ha–1) in Jiangsu province, China. As a test, we studied the variety of soil bacterial composition, diversity, and function using 16S rRNA gene sequencing. The results showed that soil Zn application reduced the diversity of microbial community, but the bacterial network was more closely linked, and the metabolic function of bacterial community was improved, which increased the grain yield (17.34–19.52%) and enriched the Zn content of polished rice (1.40–20.05%). Specifically, redundancy analysis (RDA) and Mantel’s test results revealed soil total nitrogen (TN) was the primary driver that led to a community shift in the rice rhizosphere bacterial community, and soil organic carbon (SOC) was considered to have a strong influence on dominant phyla. Furthermore, network analysis indicated the most critical bacterial taxa were identified as Actinobacteria, Bacteroidetes, Proteobacteria, and Chloroflexi based on their topological roles of microorganisms. KEGG metabolic pathway prediction demonstrated that soil Zn application significantly (p < 0.05) improved lipid metabolism, amino acid metabolism, carbohydrate metabolism, and xenobiotic biodegradation. Overall, their positive effects were different among rice varieties, of which Nanjing-9108 (NJ9108) performed better. This study opens new avenues to deeply understand the plant and soil–microbe interactions by the application of fertilizer and further navigates the development of Zn-rich rice cultivation strategies.

Microcystin-LR (MC-LR), a potent hepatotoxin can cause liver damages. However, research on hepatic lipid metabolism caused by long-term exposure to environmental concentrations MC-LR is limited. In the current study, mice were exposed to various low concentrations of MC-LR (0, 1, 30, 60, 90, 120 μg/L in the drinking water) for 9 months. The general parameters, serum and liver lipids, liver tissue pathology, lipid metabolism-related genes and proteins of liver were investigated. The results show that chronic MC-LR exposure had increased the levels of triglyceride (TG) and total cholesterol (TC) in serum and liver. In addition, histological observation revealed that hepatic lobules were disordered with obvious inflammatory cell infiltration and lipid droplets. More importantly, the mRNA and proteins expression levels of lipid synthesis-related nuclear sterol regulatory element binding protein-1c (nSREBP-1c), SREBP-1c, cluster of differentiation 36 (CD36), acetyl-CoA-carboxylase1 (ACC1), stearoyl-CoA desaturase1 (SCD1) and fatty acid synthase (FASN) were increased in MC-LR treated groups, the expression levels of fatty acids β-oxidation related genes peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) was decreased after exposure to 60–120 μg/L MC-LR. Furthermore, the inflammatory factors interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) were higher than that in the control group. All the findings indicated that mice were exposed to chronic low concentrations MC-LR caused liver inflammation and hepatic lipid metabolism disorder .

Abstract Soil labile organic carbon (LOC) responds rapidly to environmental changes and plays an important role in carbon cycle. In this study, the seasonal fluctuations in LOC, the activities of carbon-cycle related enzymes, and the bacterial and fungal communities were analyzed for soils collected from two forests, namely Betula albosinensis (Ba) and Picea asperata Mast. (Pa), in the Qinling Mountains of China. Results revealed that the seasonal average contents of microbial biomass carbon (MBC), easily oxidized organic carbon (EOC), and dissolved organic carbon (DOC) of Pa forest soil were 13.5%, 30.0% and 15.7% less than those in Ba soil. The seasonal average enzyme activities of β-1,4-glucosidase (βG), and β-1,4-xylosidase (βX) of Ba forest soils were 30.0% and 32.3% higher than those of Pa soil while the enzyme activity of cellobiohydrolase (CBH) was 19.7% lower. Furthermore, the relative abundance of Acidobacteria was significantly higher in summer than in winter, whereas the relative abundance of Bacteroidetes was higher in winter. Regarding the fungal communities, the relative abundance of Basidiomycota was lowest in winter, whereas Ascomycota predominated in the same season. In addition, the soil LOC was significantly positively correlated with the CBH, βG and βX activities. Changes in LOC were significantly correlated with Acidobacteria, Bacteroidetes and Basidiomycota. We conclude that the seasonal fluctuations in forest soil LOC fractions relied on carbon cycle-associated enzymatic activities and microorganisms, which in turn were affected by climatic conditions.