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In the United States, the last 20 years have been good to us in the rental business. For the most part, the rental industry has enjoyed attractive rates and strong [...]

Ice Systems Dominate as Thermal Storage Gains Popularity FAIRFAX, Va. - Thermal energy storage has seen a dramatic increase in acceptance in the past few years. Although mostly used for [...]

The era of simple home appliances has come to an end. New appliances with intelligence are taking their place. The next step is appliances that talk. They will not necessarily [...]

ABSTRACTDoxycycline is an antibiotic commonly used to treat Lyme disease and other bacterial infections. The MIC and minimum bactericidal concentration (MBC) for Borrelia burgdorferihave been investigated by different groups but were experimentally established in this study as a function of input cell density. We demonstrated that B. burgdorferitreated in the stationary phase has a higher probability of regrowth following removal of antibiotic. In addition, we determined experimentally and mathematically that the spirochetes which persist posttreatment do not have a longer lag phase but exhibit a lower growth rate than untreated spirochetes. Finally, we found that treating the spirochetes by pulse-dosing did not eliminate growth or reduce the persister population in vitro. From these data, we propose that B. burgdorferipersister development is stochastic and driven by slowed growth.