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238 results on '"Chandy, John A."'

101. A Case for Optimistic Coordination in HPC Storage Systems

Author

Carns, Philip, primary, Harms, Kevin, additional, Kimpe, Dries, additional, Ross, Robert, additional, Wozniak, Justin, additional, Ward, Lee, additional, Curry, Matthew, additional, Klundt, Ruth, additional, Danielson, Geoff, additional, Karakoyunlu, Cengiz, additional, Chandy, John, additional, Settlemyer, Bradley, additional, and Gropp, William, additional

Published
2012
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102. Detection of antigen-specific B cells to Plasmodium falciparum apical membrane antigen-1 and circumsporozoite protein in humans and immunized mice (P3025)

Author

Oludare Odumade, Anne Frosch, Justin Taylor, Joanne Dehnbostel, and Chandy John

Subjects
Immunology, Immunology and Allergy
Abstract

Worldwide, there are an estimated 216 million cases of malaria annually and of those affected 655,000 will succumb to the disease. Antibody responses to infection have been shown to be critical in limiting infection and disease, but the mechanisms by which these are acquired or lost are poorly understood. Various hypotheses have been proposed for dysfunctional humoral responses including B cell exhaustion, germinal center architectural disruption, parasite antigenic variation and inhibitory innate immune signaling. However, the relative infrequency of malaria specific B cells in the periphery has limited targeted detection of these cells. We present a strategy for phenotypic analyses of malaria specific B cells in peripheral blood using tetramerized biotinylated malaria antigen coupled to phycoerythrin labeled streptavidin, magnetic bead enrichment and cytometric flow analysis. Using this technique, we demonstrate the detection of an antigen specific germinal center reaction in B6 mice after immunization with P.pastoris expressing recombinant Plasmodium falciparum apical membrane antigen-1 and circumsporozoite protein. Preliminary results in humans identified low frequency B cells specific to these two antigens. Overall, our results suggest that this technique will be a valuable tool in studying naturally acquired and vaccine derived malaria specific B cell responses.

Published
2013

114. Uncovering errors

Author

Narayan, Sumit, primary, Chandy, John A., additional, Lang, Samuel, additional, Carns, Philip, additional, and Ross, Robert, additional

Published
2009
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129. Design of four-state inverter based on spatial wave-function switched FETs

Author

Karmakar, Supriya, Chandy, John A., and Jain, Faquir C.

Abstract

A spatial wave-function switched field effect transistor (SWSFET) conducts current from the source to the drain region through different channels inside the FET based on the applied gate voltage. A circuit model of SWSFET is developed by modifying Berkeley short-channel IGFET model (BSIM 3.2.0), and a four-state inverter is designed based on that model. This four-state inverter may become a key element in future quaternary logic circuit design.

Published
2015
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135. Clinical governance in action: radiology

Author

Chandy, John, Goodfellow, Thomas, and Vohrah, Anil

Abstract

Articles and conferences on clinical governance abound, but much of the content is theoretical. This article describes how clinical governance may be introduced in a busy radiology department in a straightforward and practical way, with benefits to both the radiologist and patient.

Published
2000
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136. MOESM1 of Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial

Author

Hawkes, Michael, Conroy, Andrea, Opoka, Robert, Hermann, Laura, Thorpe, Kevin, McDonald, Chloe, Kim, Hani, Higgins, Sarah, Namasopo, Sophie, Chandy John, Miller, Chris, W. Liles, and Kain, Kevin

Subjects
3. Good health
Abstract

Additional file 1. Sensitivity analyses and quality measures for clinical trial â Inhaled nitric oxide as adjunctive therapy for severe malariaâ . Description: Sensitivity analyses on the primary and secondary (mortality) endpoints are provided. Measures of the quality of blinding and quality of clinical care in the trial are described.

137. Additional file 1: of Malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less than 5Â years in Uganda and Kenya: study protocol for a multi-centre, two-arm, randomised, placebo-controlled, superiority trial

Author

Kwambai, Titus, Aggrey Dhabangi, Idro, Richard, Opoka, Robert, Kariuki, Simon, Samuels, Aaron, Meghna Desai, Hensbroek, Michael Van, Chandy John, Robberstad, Bjarne, Duolao Wang, Kamija Phiri, and Kuile, Feiko Ter

Subjects
3. Good health
Abstract

Full study protocol (including SPIRIT figure): v4.0, dated 06 Feb 2018. (PDF 3510 kb)

138. MOESM1 of HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya

Author

Eliud Odhiambo, Dibyadyuti Datta, Guyah, Bernard, Ayodo, George, Ondigo, Bartholomew, Benard Abong’O, Chandy John, and Frosch, Anne

Subjects
parasitic diseases, complex mixtures, 3. Good health
Abstract

Additional file 1: Fig. S1. Sample scatter plots of AMA1 antibody concentrations versus against VL and CRP. Fig. S2. IgG3:IgG1 ratio for AMA1 and GLURP specific antibodies by CD4 counts. Table S1. Inter-assay and Intra-assay CV for IgM and IgG subclasses.

139. MOESM1 of HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya

Author

Eliud Odhiambo, Dibyadyuti Datta, Guyah, Bernard, Ayodo, George, Ondigo, Bartholomew, Benard Abong’O, Chandy John, and Frosch, Anne

Subjects
parasitic diseases, complex mixtures, 3. Good health
Abstract

Additional file 1: Fig. S1. Sample scatter plots of AMA1 antibody concentrations versus against VL and CRP. Fig. S2. IgG3:IgG1 ratio for AMA1 and GLURP specific antibodies by CD4 counts. Table S1. Inter-assay and Intra-assay CV for IgM and IgG subclasses.

140. Additional file 2: Table S1. of Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria â a proposed model-derived age-based regimen for sub-Saharan Africa

Author

W. Taylor, Htee Naw, Maitland, Kathryn, Williams, Thomas, Kapulu, Melissa, D’Alessandro, Umberto, Berkley, James, Bejon, Philip, Okebe, Joseph, Achan, Jane, Amambua, Alfred, Affara, Muna, Nwakanma, Davis, Geertruyden, Jean-Pierre Van, Muhindo Mavoko, Lutumba, Pascal, Junior Matangila, Philipe Brasseur, Piola, Patrice, Rindra Randremanana, Lasry, Estrella, Fanello, Caterina, Onyamboko, Marie, Schramm, Birgit, Zolia Yah, Jones, Joel, Fairhurst, Rick, Mahamadou Diakite, Malenga, Grace, Molyneux, Malcolm, Rwagacondo, Claude, Obonyo, Charles, Endalamaw Gadisa, Aseffa, Abraham, Mores Loolpapit, Marie-Claire Henry, Dorsey, Grant, Chandy John, Sodiomon Sirima, Barnes, Karen, Kremsner, Peter, Day, Nicholas, White, Nicholas, and Mavuto Mukaka

Subjects
3. Good health
Abstract

Data type by country. (DOCX 14 kb)

141. MOESM1 of Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial

Author

Hawkes, Michael, Conroy, Andrea, Opoka, Robert, Hermann, Laura, Thorpe, Kevin, McDonald, Chloe, Kim, Hani, Higgins, Sarah, Namasopo, Sophie, Chandy John, Miller, Chris, W. Liles, and Kain, Kevin

Subjects
3. Good health
Abstract

Additional file 1. Sensitivity analyses and quality measures for clinical trial â Inhaled nitric oxide as adjunctive therapy for severe malariaâ . Description: Sensitivity analyses on the primary and secondary (mortality) endpoints are provided. Measures of the quality of blinding and quality of clinical care in the trial are described.

142. Additional file 1: of Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria â a proposed model-derived age-based regimen for sub-Saharan Africa

Author

W. Taylor, Htee Naw, Maitland, Kathryn, Williams, Thomas, Kapulu, Melissa, D’Alessandro, Umberto, Berkley, James, Bejon, Philip, Okebe, Joseph, Achan, Jane, Amambua, Alfred, Affara, Muna, Nwakanma, Davis, Geertruyden, Jean-Pierre Van, Muhindo Mavoko, Lutumba, Pascal, Junior Matangila, Philipe Brasseur, Piola, Patrice, Rindra Randremanana, Lasry, Estrella, Fanello, Caterina, Onyamboko, Marie, Schramm, Birgit, Zolia Yah, Jones, Joel, Fairhurst, Rick, Mahamadou Diakite, Malenga, Grace, Molyneux, Malcolm, Rwagacondo, Claude, Obonyo, Charles, Endalamaw Gadisa, Aseffa, Abraham, Mores Loolpapit, Marie-Claire Henry, Dorsey, Grant, Chandy John, Sodiomon Sirima, Barnes, Karen, Kremsner, Peter, Day, Nicholas, White, Nicholas, and Mavuto Mukaka

Subjects
body regions, nervous system, fungi, 3. Good health
Abstract

Weight-for-age growth curves. (PDF 1202 kb)

143. Additional file 1: of Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria â a proposed model-derived age-based regimen for sub-Saharan Africa

Author

W. Taylor, Htee Naw, Maitland, Kathryn, Williams, Thomas, Kapulu, Melissa, D’Alessandro, Umberto, Berkley, James, Bejon, Philip, Okebe, Joseph, Achan, Jane, Amambua, Alfred, Affara, Muna, Nwakanma, Davis, Geertruyden, Jean-Pierre Van, Muhindo Mavoko, Lutumba, Pascal, Junior Matangila, Philipe Brasseur, Piola, Patrice, Rindra Randremanana, Lasry, Estrella, Fanello, Caterina, Onyamboko, Marie, Schramm, Birgit, Zolia Yah, Jones, Joel, Fairhurst, Rick, Mahamadou Diakite, Malenga, Grace, Molyneux, Malcolm, Rwagacondo, Claude, Obonyo, Charles, Endalamaw Gadisa, Aseffa, Abraham, Mores Loolpapit, Marie-Claire Henry, Dorsey, Grant, Chandy John, Sodiomon Sirima, Barnes, Karen, Kremsner, Peter, Day, Nicholas, White, Nicholas, and Mavuto Mukaka

Subjects
body regions, nervous system, fungi, 3. Good health
Abstract

Weight-for-age growth curves. (PDF 1202 kb)

144. Additional file 1: of Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria

Author

Conroy, Andrea, Opoka, Robert, Bangirana, Paul, Idro, Richard, Ssenkusu, John, Dibyadyuti Datta, Hodges, James, Morgan, Catherine, and Chandy John

Subjects
3. Good health
Abstract

I. Methods. Supplementary methods describing the study population and additional details on assessment of disease severity, kidney function, retinopathy, neurocognitive evaluation, and statistical analysis. II. Results. Relationship between AKI and nephrotoxic medication use during hospitalization. III. Supplementary tables. Table S1-S13. (DOCX 89 kb)

145. Additional file 2: Table S1. of Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria â a proposed model-derived age-based regimen for sub-Saharan Africa

Author

W. Taylor, Htee Naw, Maitland, Kathryn, Williams, Thomas, Kapulu, Melissa, D’Alessandro, Umberto, Berkley, James, Bejon, Philip, Okebe, Joseph, Achan, Jane, Amambua, Alfred, Affara, Muna, Nwakanma, Davis, Geertruyden, Jean-Pierre Van, Muhindo Mavoko, Lutumba, Pascal, Junior Matangila, Philipe Brasseur, Piola, Patrice, Rindra Randremanana, Lasry, Estrella, Fanello, Caterina, Onyamboko, Marie, Schramm, Birgit, Zolia Yah, Jones, Joel, Fairhurst, Rick, Mahamadou Diakite, Malenga, Grace, Molyneux, Malcolm, Rwagacondo, Claude, Obonyo, Charles, Endalamaw Gadisa, Aseffa, Abraham, Mores Loolpapit, Marie-Claire Henry, Dorsey, Grant, Chandy John, Sodiomon Sirima, Barnes, Karen, Kremsner, Peter, Day, Nicholas, White, Nicholas, and Mavuto Mukaka

Subjects
3. Good health
Abstract

Data type by country. (DOCX 14 kb)

146. Additional file 1: of Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria

Author

Conroy, Andrea, Opoka, Robert, Bangirana, Paul, Idro, Richard, Ssenkusu, John, Dibyadyuti Datta, Hodges, James, Morgan, Catherine, and Chandy John

Subjects
3. Good health
Abstract

I. Methods. Supplementary methods describing the study population and additional details on assessment of disease severity, kidney function, retinopathy, neurocognitive evaluation, and statistical analysis. II. Results. Relationship between AKI and nephrotoxic medication use during hospitalization. III. Supplementary tables. Table S1-S13. (DOCX 89 kb)

147. Additional file 1: of Malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less than 5Â years in Uganda and Kenya: study protocol for a multi-centre, two-arm, randomised, placebo-controlled, superiority trial

Author

Kwambai, Titus, Aggrey Dhabangi, Idro, Richard, Opoka, Robert, Kariuki, Simon, Samuels, Aaron, Meghna Desai, Hensbroek, Michael Van, Chandy John, Robberstad, Bjarne, Duolao Wang, Kamija Phiri, and Kuile, Feiko Ter

Subjects
3. Good health
Abstract

Full study protocol (including SPIRIT figure): v4.0, dated 06 Feb 2018. (PDF 3123 kb)

148. Additional file 1: of Malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less than 5Â years in Uganda and Kenya: study protocol for a multi-centre, two-arm, randomised, placebo-controlled, superiority trial

Author

Kwambai, Titus, Aggrey Dhabangi, Idro, Richard, Opoka, Robert, Kariuki, Simon, Samuels, Aaron, Meghna Desai, Hensbroek, Michael Van, Chandy John, Robberstad, Bjarne, Duolao Wang, Kamija Phiri, and Kuile, Feiko Ter

Subjects
3. Good health
Abstract

Full study protocol (including SPIRIT figure): v4.0, dated 06 Feb 2018. (PDF 3123 kb)

150. What's ahead for health in 2004?

Author

Graham, David, Khan, Mohib, Johnson, James, Panting, Gerard, Catto, Graeme, Miller, Paul, Scotland, Alastair, Chandy, John, and Dunlop, Bill

Abstract

Presents the views of several leaders in the British medical profession regarding the issues facing the profession in 2004. Reorganization of the General Medical Council; Discussion of the 2004 consultant contract; Initiatives that will address women's health issues.

Published
2004

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