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102. Contributors

Author

Arora, Alisha, primary, Ahmad, Syed A., additional, Binkley, Charles E., additional, Burke, William M., additional, Chang, Alfred E., additional, Cimmino, Vincent M., additional, Diehl, Kathleen M., additional, Doherty, Gerard M., additional, DuBay, Derek A., additional, Gartner, Elaina M., additional, Gauger, Paul G., additional, Geiger, James D., additional, Gitlin, Scott D., additional, Graziano, Kathleen, additional, Hodul, Pamela J., additional, Huang, Emina H., additional, Iannettoni, Mark D., additional, Woods Ignatoski, Kathleen M., additional, Johnston, Carolyn, additional, Kim, Joseph, additional, Lin, Jules, additional, Ly, Quan P., additional, Newman, Erika A., additional, Pow-Sang, Julio M., additional, Ray, Michael E., additional, Rodriguez, Alejandro, additional, Rollison, Dana E., additional, Sabel, Michael S., additional, Shaughnessy, Elizabeth A., additional, Simeone, Diane M., additional, Sondak, Vernon K., additional, Sugg, Sonia L., additional, Sussman, Jeffrey J., additional, Tsai, Susan, additional, Williams-Covington, Candace Y., additional, Wilson, Keith, additional, Wolfe, Michael J., additional, and Woodrum, Derek T., additional

Published
2007
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113. Essential Practice of Surgery

Author

Li, Michelle, primary, Norton, Jeffrey A., additional, Bollinger, R. Randal, additional, Chang, Alfred E., additional, Lowry, Stephen F., additional, Mulvihill, Sean J., additional, Pass, Harvey I., additional, and Thompson, Robert W., additional

Published
2003
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120. Contributors

Author

Abonour, Rafat, primary, Abrams, Scott I., additional, Aguilar, Laura K., additional, Aguilar-Cordova, Estuardo, additional, Albelda, Steven M., additional, Albertini, Mark R., additional, Ayala, Gustavo, additional, Banchereau, Jacques, additional, Baum, Christopher, additional, Becker, Christian M., additional, Beger, Carmela, additional, Bertino, Joseph R., additional, Blanco, Patrick, additional, Budak-Alpdogan, Tulin, additional, Butler, E. Brian, additional, Butterfield, Lisa H., additional, Chang, Alfred E., additional, Chatterjee, Saswati, additional, Chin, K.V., additional, Clements, Virginia K., additional, Cooper, Mark J., additional, Cornetta, Kenneth, additional, Croop, James M., additional, Dissanayake, Samudra, additional, Eck, Stephen L., additional, Economou, James S., additional, Eisenlohr, Laurence C., additional, El-Deiry, Wafik S., additional, Farnebo, Filip A., additional, Feldman, Andrew L., additional, Folkman, Judah, additional, Gerson, Stanton L., additional, Gilbert, Mileka, additional, Gomella, Leonard G., additional, Gorski, David H., additional, Hait, William N., additional, Hung, Mien-Chie, additional, Judy, Kevin D., additional, Kadmon, Dov, additional, Kearney, Thomas, additional, Kim, Edsel U., additional, King, David M., additional, Kirn, David, additional, Koç, Omer N., additional, Krüger, Martin, additional, Kuo, Calvin J., additional, Lampert, C., additional, Lattime, Edmund C., additional, Lebedeva, Irina V., additional, Libutti, Steven K., additional, Lyerly, H. Kim, additional, Mastrangelo, Michael J., additional, Mauceri, Helena J., additional, McCall, A.M., additional, McDonagh, Kevin T., additional, McIvor, R. Scott, additional, Meng, Raymond D., additional, Miles, Brian, additional, Moolten, Frederick L., additional, Morse, Michael A., additional, Mroz, Paula J., additional, Mulé, James J., additional, Nair, Smita K., additional, O'Connor, Owen A., additional, Ostertag, Wolfram, additional, Ostrand-Rosenberg, Suzanne, additional, Palucka, A. Karolina, additional, Pulaski, Beth A., additional, Qi, Ling, additional, Rakhmilevich, Alexander L., additional, Reese, Jane S., additional, Reiss, Michael, additional, Ribas, Antoni, additional, Rivière, Isabelle, additional, Roth, Justin C., additional, Sadelain, Michel, additional, Shao, Ruping, additional, Stein, C.A., additional, Sterman, Daniel H., additional, Stocking, Carol, additional, Teh, Bin S., additional, Thompson, Timothy C., additional, Toppmeyer, Deborah, additional, Verfaillie, Catherine M., additional, Vlachaki, Maria T., additional, von Laer, Dorothee, additional, Weichselbaum, Ralph R., additional, Weiner, L.M., additional, Wheeler, Thomas, additional, Wilke, Lee G., additional, Wong, K.K., additional, Wong-Staal, Flossie, additional, Yan, Duen-Hwa, additional, Zielske, Steven P., additional, and Zhao, Robert CH, additional

Published
2002
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123. The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma

Author

Paek, Sandra C., Griffith, Kent A., Johnson, Timothy M., Sondak, Vernon K., Wong, Sandra L., Chang, Alfred E., Cimmino, Vincent M., Lowe, Lori, Bradford, Carol R., Rees, Riley S., and Sabel, Michael S.

Subjects
Melanoma -- Complications and side effects, Lymphatic metastasis -- Risk factors, Lymphatic metastasis -- Diagnosis, Lymphatic metastasis -- Research, Health
Published
2007

126. Tumor immunology

Author

Shu, Suyu, Plautz, Gregory E., Krauss, John C., and Chang, Alfred E.

Subjects
Tumors -- Physiological aspects, Tumor antigens -- Physiological aspects, Cancer -- Physiological aspects, Immunotherapy -- Analysis
Abstract

The immune system may discriminate normal cells from abnormal cells, yet some tumors escape immune recognition and destruction mechanisms. Tumor cells may hide from the immune system by not expressing identifying surface proteins, secreting immunosuppressive agents, or expressing proteins the system identifies as normal. The immune system may control virus-related tumors by killing infected cells. Immunotherapy may enhance identification of tumor cells, heighten immune recognition of normal cells, or deliver antibodies that bind to tumors or deliver toxic agents to tumor cells., Malignant tumors express antigens that may stimulate and serve as targets for antitumor immunity. Virally induced tumors usually contain integrated proviral genomes in their cellular genomes and often express viral genome-encoded proteins that may stimulate specific host immune responses. Antigens unique to individual tumors that stimulate specific rejection of transplanted tumors have been demonstrated only in experimental animals. Other tumor antigens that potentially can stimulate immune responses are shared by different tumors. These include products of mutated or rearranged oncogenes or tumor-suppressor genes. Tumors may also overexpress tissue differentiation antigens or embryonic antigens, which also have the potential to be recognized by the immune system. The recent identification of tumor antigens recognized by cytotoxic T cells opens up new possibilities for constructing chemically defined antigens for specific immunotherapy. Treatment of malignant tumors in humans by immunologic approaches, although theoretically attractive, has not yet succeeded on a large scale. Important progress in immunotherapy of cancer is emerging with several different treatment modalities. JAMA. 1997;278:1972-1981

Published
1997

133. Sentinel node biopsy prior to neoadjuvant chemotherapy

Author

Sabel, Michael S., Schott, Anne F., Kleer, Celina G., Merajver, Sofia, Cimmino, Vincent M., Diehl, Kathleen M., Hayes, Daniel F., Chang, Alfred E., and Pierce, Lori J.

Subjects
Breast cancer -- Diagnosis, Cancer patients -- Medical examination, Cancer patients -- Comparative analysis, Health
Published
2003

136. Abstract 4981: HER2-targeted antibody drug conjugates (ADCs) induce host immunity against cancer stem cells and are enhanced by anti-PD-L1

Author

Xia, Leiming, primary, Wen, Lu, additional, Wu, Gang, additional, Zhang, Tao, additional, Comer, Frank, additional, Hinrichs, Mary Jane Masson, additional, Oberst, Michael, additional, Coats, Steven R., additional, Chang, Alfred E., additional, Liu, Yuanyuan, additional, Bao, Yangyi, additional, Wicha, Max, additional, and Li, Qiao, additional

Published
2019
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146. Economic implications of hepatic arterial infusion chemotherapy in treatment of nonresectable colorectal live metastases

Author

Durand-Zaleski, Isabelle, Roche, Beatrice, Buyse, Marc, Carlson, Robert, O'Connell, Michael J., Rougier, Philippe, Chang, Alfred E., Sondak, Vernon K., Kemeny, Margaret M., Allen-Mersh, Tim G., Fagniez, Pierre-Louis, Le Bourgeois, Jean-Paul, and Piedbois, Pascal

Subjects
Colorectal cancer -- Metastasis, Liver cancer, Metastasis, Chemotherapy -- Dosage and administration, Health
Abstract

Background: Approximately 20% of patients with colorectal cancer die of metastases confined to the liver. A meta-analysis recently performed by our group confirmed that in these patients hepatic arterial infusion of 5-fluoro-2'-deoxyuridine, compared with intravenous chemotherapy with fluoropyrimidines or supportive care (including symptom palliation when necessary), improved tumor response. Purpose: Because of the high cost of hepatic arterial infusion, we undertook a cost-effectiveness analysis that related the cost of such therapy to its medical efficacy. Methods: The patient population was drawn from the seven randomized clinical trials included in the meta-analysis and included individual data on 654 patients. Of these seven trials, five compared hepatic arterial infusion and intravenous chemotherapy and two compared hepatic arterial infusion and a control group in which some patients could be left untreated. Patients assigned to receive hepatic arterial infusion made up the hepatic arterial infusion group; the other patients constituted the control group. The measures of efficacy were survival and tumor response. Health-care costs (in 1995 U.S. dollars) were computed over the duration of patient follow-up and were derived from actual costs in two centers, one at Henri Mondor Hospital (Paris, France) and the other at Stanford University Medical Center (Palo Alto, CA). The total cost of treatment included the initial procedure, chemotherapy cycles, and main complications. Results: The mean gain in life expectancy in the hepatic arterial infusion group compared with the control group was 3.2 months (standard error = 1.0 month). For patients treated by hepatic arterial infusion in Paris, the hepatic arterial infusion pump, initial hospitalization, and the entire process (including follow-up and complications) cost, on average, $8400, $15 172, and $29 562, respectively; in Palo Alto, these costs were $4700, $13 784, and $25 208, respectively. For patients in the control groups in Paris and Palo Alto, the total treatment costs were, on average, $9926 and $5928. The additional costs of hepatic arterial infusion over control treatment were $19 636 in Paris and $19 280 in Palo Alto. The cost-effectiveness (i.e., the additional cost divided by the additional benefit) with respect to survival of the patients in the hepatic arterial infusion group compared with the patients in the control group was $73 635 per life-year in Paris and $72 300 per life-year in Palo Alto. Conclusions and Implications: The cost-effectiveness of localized chemotherapy for colorectal liver metastases is within the range of accepted treatments for serious medical conditions, although it might be considered borderline by policy-makers in some countries. Prospective clinical trials should be conducted to more definitively answer this question.

Published
1997

150. Mobilizing the body's defenses against cancer

Author

Chang, Alfred E., Lotze, Michael T., and Pardoll, Drew M.

Subjects
Kidney cancer -- Care and treatment -- Drug therapy, Cancer -- Adjuvant treatment, Metastasis -- Drug therapy -- Care and treatment, Neovascularization -- Health aspects -- Growth, Information services industry -- Growth -- Health aspects, Clinical trials -- Health aspects, Cancer cells -- Growth -- Health aspects, Information services -- Growth -- Health aspects, Melanoma -- Care and treatment -- Drug therapy, Biological products -- Health aspects, Health, Company growth, Information services industry, Drug therapy, Care and treatment, Growth, Health aspects
Abstract

How to snare scattered tumor cells has been a major obstacle to successful cancer treatment. Soon patients may not have to look far beyond their own bodies for a solution. [...]

Published
1996

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