Search

Your search keyword '"Chang, Chia‑Chi"' showing total 891 results
Start Over Author "Chang, Chia‑Chi"
891 results on '"Chang, Chia‑Chi"'

101. Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment

Author

Schwabkey, Zaker I., primary, Wiesnoski, Diana H., additional, Chang, Chia-Chi, additional, Tsai, Wen-Bin, additional, Pham, Dung, additional, Ahmed, Saira S., additional, Hayase, Tomo, additional, Ortega Turrubiates, Miriam R., additional, El-Himri, Rawan K., additional, Sanchez, Christopher A., additional, Hayase, Eiko, additional, Frenk Oquendo, Annette C., additional, Miyama, Takahiko, additional, Halsey, Taylor M., additional, Heckel, Brooke E., additional, Brown, Alexandria N., additional, Jin, Yimei, additional, Raybaud, Mathilde, additional, Prasad, Rishika, additional, Flores, Ivonne, additional, McDaniel, Lauren, additional, Chapa, Valerie, additional, Lorenzi, Philip L., additional, Warmoes, Marc O., additional, Tan, Lin, additional, Swennes, Alton G., additional, Fowler, Stephanie, additional, Conner, Margaret, additional, McHugh, Kevin, additional, Graf, Tyler, additional, Jensen, Vanessa B., additional, Peterson, Christine B., additional, Do, Kim-Anh, additional, Zhang, Liangliang, additional, Shi, Yushu, additional, Wang, Yinghong, additional, Galloway-Pena, Jessica R., additional, Okhuysen, Pablo C., additional, Daniel-MacDougall, Carrie R., additional, Shono, Yusuke, additional, Burgos da Silva, Marina, additional, Peled, Jonathan U., additional, van den Brink, Marcel R.M., additional, Ajami, Nadim, additional, Wargo, Jennifer A., additional, Reddy, Pavan, additional, Valdivia, Raphael H., additional, Davey, Lauren, additional, Rondon, Gabriela, additional, Srour, Samer A., additional, Mehta, Rohtesh S., additional, Alousi, Amin M., additional, Shpall, Elizabeth J., additional, Champlin, Richard E., additional, Shelburne, Samuel A., additional, Molldrem, Jeffrey J., additional, Jamal, Mohamed A., additional, Karmouch, Jennifer L., additional, and Jenq, Robert R., additional

Published
2022
Full Text
View/download PDF

102. Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease

Author

Hayase, Eiko, primary, Hayase, Tomo, additional, Jamal, Mohamed A., additional, Miyama, Takahiko, additional, Chang, Chia-Chi, additional, Ortega, Miriam R., additional, Ahmed, Saira S., additional, Karmouch, Jennifer L., additional, Sanchez, Christopher A., additional, Brown, Alexandria N., additional, El-Himri, Rawan K., additional, Flores, Ivonne I., additional, McDaniel, Lauren K., additional, Pham, Dung, additional, Halsey, Taylor, additional, Frenk, Annette C., additional, Chapa, Valerie A., additional, Heckel, Brooke E., additional, Jin, Yimei, additional, Tsai, Wen-Bin, additional, Prasad, Rishika, additional, Tan, Lin, additional, Veillon, Lucas, additional, Ajami, Nadim J., additional, Wargo, Jennifer A., additional, Galloway-Peña, Jessica, additional, Shelburne, Samuel, additional, Chemaly, Roy F., additional, Davey, Lauren, additional, Glowacki, Robert W.P., additional, Liu, Chen, additional, Rondon, Gabriela, additional, Alousi, Amin M., additional, Molldrem, Jeffrey J., additional, Champlin, Richard E., additional, Shpall, Elizabeth J., additional, Valdivia, Raphael H., additional, Martens, Eric C., additional, Lorenzi, Philip L., additional, and Jenq, Robert R., additional

Published
2022
Full Text
View/download PDF

109. Microbiome alteration via fecal microbiota transplantation is effective for refractory immune checkpoint inhibitor–induced colitis.

Author

Halsey, Taylor M., Thomas, Anusha S., Hayase, Tomo, Ma, Weijie, Abu-Sbeih, Hamzah, Sun, Baohua, Parra, Edwin Roger, Jiang, Zhi-Dong, DuPont, Herbert L., Sanchez, Christopher, El-Himri, Rawan, Brown, Alexandria, Flores, Ivonne, McDaniel, Lauren, Ortega Turrubiates, Miriam, Hensel, Matthew, Pham, Dung, Watowich, Stephanie S., Hayase, Eiko, and Chang, Chia-Chi

Subjects
FECAL microbiota transplantation, GUT microbiome, IMMUNE checkpoint proteins, PROGRAMMED cell death 1 receptors, COLITIS, DRUG side effects, IMMUNE checkpoint inhibitors
Abstract

Immune checkpoint inhibitors (ICIs) target advanced malignancies with high efficacy but also predispose patients to immune-related adverse events like immune-mediated colitis (IMC). Given the association between gut bacteria with response to ICI therapy and subsequent IMC, fecal microbiota transplantation (FMT) represents a feasible way to manipulate microbial composition in patients, with a potential benefit for IMC. Here, we present a large case series of 12 patients with refractory IMC who underwent FMT from healthy donors as salvage therapy. All 12 patients had grade 3 or 4 ICI-related diarrhea or colitis that failed to respond to standard first-line (corticosteroids) and second-line immunosuppression (infliximab or vedolizumab). Ten patients (83%) achieved symptom improvement after FMT, and three patients (25%) required repeat FMT, two of whom had no subsequent response. At the end of the study, 92% achieved IMC clinical remission. 16S rRNA sequencing of patient stool samples revealed that compositional differences between FMT donors and patients with IMC before FMT were associated with a complete response after FMT. Comparison of pre- and post-FMT stool samples in patients with complete responses showed significant increases in alpha diversity and increases in the abundances of Collinsella and Bifidobacterium, which were depleted in FMT responders before FMT. Histologically evaluable complete response patients also had decreases in select immune cells , including CD8+ T cells, in the colon after FMT when compared with non-complete response patients (n = 4). This study validates FMT as an effective treatment strategy for IMC and gives insights into the microbial signatures that may play a critical role in FMT response. Editor's summary: Immune checkpoint inhibitor treatment can result in immune-mediated colitis (IMC), but remedies for this adverse event that do not compromise cancer treatment are lacking. Halsey et al. show in a larger case series that fecal microbiota transfer (FMT) from healthy donors promotes resolution of refractory immune checkpoint-inhibitor mediated colitis in patients with cancer. Of 12 patients with severe diarrhea or colitis who received FMT, more than half eventually achieved remission of these side effects after FMT alone, a response linked to increased gut Collinsella and Bifidobacterium species and decreased colonic CD8+ T cells. —Catherine Charneski [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

110. Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

Author

Chen, Yang, primary, Yang, Sujuan, additional, Tavormina, Jena, additional, Tampe, Desiree, additional, Zeisberg, Michael, additional, Wang, Huamin, additional, Mahadevan, Krishnan K., additional, Wu, Chang-Jiun, additional, Sugimoto, Hikaru, additional, Chang, Chia-Chi, additional, Jenq, Robert R., additional, McAndrews, Kathleen M., additional, and Kalluri, Raghu, additional

Published
2022
Full Text
View/download PDF

118. Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

Author

Wang, Yinghong, Wiesnoski, Diana H., Helmink, Beth A., Gopalakrishnan, Vancheswaran, Choi, Kati, DuPont, Hebert L., Jiang, Zhi-Dong, Abu-Sbeih, Hamzah, Sanchez, Christopher A., Chang, Chia-Chi, Parra, Edwin R., Francisco-Cruz, Alejandro, Raju, Gottumukkala S., Stroehlein, John R., Campbell, Matthew T., Gao, Jianjun, Subudhi, Sumit K., Maru, Dipen M., Blando, Jorge M., Lazar, Alexander J., Allison, James P., Sharma, Padmanee, Tetzlaff, Michael T., Wargo, Jennifer A., and Jenq, Robert R.

Published
2019
Full Text
View/download PDF

122. A nurse‐led multicentre randomized controlled trial on effectiveness and cost‐effectiveness of Chinese iSupport for dementia program: A study protocol

Author

Xiao, Lily Dongxia, primary, Wang, Jing, additional, Ratcliffe, Julie, additional, Ullah, Shahid, additional, Brodaty, Henry, additional, Brijnath, Bianca, additional, Chang, Hui‐Chen ( Rita), additional, Wang, Huali, additional, Chang, Chia‐Chi, additional, Kwok, Timothy, additional, and Zhu, Mingxia, additional

Published
2022
Full Text
View/download PDF

134. A polyamine-centric, blood-based metabolite panel predictive of poor response to CAR-T cell therapy in large B cell lymphoma

Author

Johannes F. Fahrmann, Neeraj Y. Saini, Chang Chia-Chi, Ehsan Irajizad, Paolo Strati, Ranjit Nair, Luis E. Fayad, Sairah Ahmed, Hun Ju Lee, Swaminathan Iyer, Raphael Steiner, Jody Vykoukal, Ranran Wu, Jennifer B. Dennison, Loretta Nastoupil, Preetesh Jain, Michael Wang, Michael Green, Jason Westin, Viktoria Blumenberg, Marco Davila, Richard Champlin, Elizabeth J. Shpall, Partow Kebriaei, Christopher R. Flowers, Michael Jain, Robert Jenq, Christoph K. Stein-Thoeringer, Marion Subklewe, Sattva S. Neelapu, and Sam Hanash

Subjects
Receptors, Chimeric Antigen, Antigens, CD19, Polyamines, Cell- and Tissue-Based Therapy, Humans, Lymphoma, Large B-Cell, Diffuse, General Biochemistry, Genetics and Molecular Biology
Abstract

Anti-CD19 chimeric antigen receptor (CAR) T cell therapy for relapsed or refractory (r/r) large B cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether an MYC-driven polyamine signature, as a liquid biopsy, is predictive of response to anti-CD19 CAR-T therapy in patients with r/r LBCL. Elevated plasma acetylated polyamines were associated with non-durable response. Concordantly, increased expression of spermidine synthase, a key enzyme that regulates levels of acetylated spermidine, was prognostic for survival in r/r LBCL. A broad metabolite screen identified additional markers that resulted in a 6-marker panel (6MetP) consisting of acetylspermidine, diacetylspermidine, and lysophospholipids, which was validated in an independent set from another institution as predictive of non-durable response to CAR-T therapy. A polyamine centric metabolomics liquid biopsy panel has predictive value for response to CAR-T therapy in r/r LBCL.

Published
2021

140. A Technical Analysis of Solid Recovered Fuel from Torrefied Jatropha Seed Residue via a Two-Stage Mechanical Screw Press and Solvent Extraction Process

Author

Yuan, Min-Hao, primary, Chang, Chia-Chi, additional, Hsu, Tsung-Chi, additional, Shie, Je-Lueng, additional, Chen, Yi-Hung, additional, Chang, Ching-Yuan, additional, Lin, Cheng-Fang, additional, Yu, Chang-Ping, additional, Wu, Chao-Hsiung, additional, Do, Manh Van, additional, Lin, Far-Ching, additional, Lee, Duu-Jong, additional, Liu, Bo-Liang, additional, Chen, Yen-Hau, additional, and Huang, Michael, additional

Published
2021
Full Text
View/download PDF

145. Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment

Author

Schwabkey, Zaker, primary, Wiesnoski, Diana, additional, Chang, Chia-Chi, additional, Tsai, Wen-Bin, additional, Pham, Dung, additional, Ahmed, Saira S, additional, Hayase, Tomo, additional, Ortega Turrubiates, Miriam R, additional, El-Himri, Rawan K, additional, Sanchez, Christopher A, additional, Hayase, Eiko, additional, Frenk Oquendo, Annette C, additional, Miyama, Takahiko, additional, Halsey, Taylor M, additional, Heckel, Brooke E, additional, Brown, Alexandria N, additional, Jin, Yimei, additional, Lorenzi, Philip L, additional, Warmoes, Marc O, additional, Tan, Lin, additional, Swennes, Alton, additional, Jensen, Vanessa B, additional, Peterson, Christine B, additional, Do, Kim-Anh, additional, Zhang, Liangliang, additional, Shi, Yushu, additional, Wang, Yinghong, additional, Galloway-Pena, Jessica R, additional, Okhuysen, Pablo C, additional, Daniel-MacDougall, Carrie, additional, Shono, Yusuke, additional, Burgos da Silva, Marina, additional, Peled, Jonathan, additional, van den Brink, Marcel RM, additional, Ajami, Nadim J, additional, Wargo, Jennifer, additional, Rondon, Gabriela, additional, Srour, Samer A, additional, Mehta, Rohtesh S, additional, Alousi, Amin M, additional, Shpall, Elizabeth J, additional, Champlin, Richard E, additional, Shelburne, Samuel A, additional, Molldrem, Jeffrey J, additional, Jamal, Mohamed A, additional, Karmouch, Jennifer L, additional, and Jenq, Robert R, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results