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461 results on '"Chen, I-How"'

103. PET and PET/CT of the Neck Lymph Nodes Improves Risk Prediction in Patients with Squamous Cell Carcinoma of the Oral Cavity

Author

Liao, Chun-Ta, primary, Wang, Hung-Ming, additional, Huang, Shiang-Fu, additional, Chen, I-How, additional, Kang, Chung-Jan, additional, Lin, Chien-Yu, additional, Fan, Kang-Hsing, additional, Ng, Shu-Hang, additional, Hsueh, Chuen, additional, Lee, Li-Yu, additional, Lin, Chih-Hung, additional, and Yen, Tzu-Chen, additional

Published
2011
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113. Pretreatment Primary Tumor SUVmax Measured by FDG-PET and Pathologic Tumor Depth Predict for Poor Outcomes in Patients With Oral Cavity Squamous Cell Carcinoma and Pathologically Positive Lymph Nodes

Author

Liao, Chun-Ta, primary, Chang, Joseph Tung-Chieh, additional, Wang, Hung-Ming, additional, Ng, Shu-Hang, additional, Hsueh, Chuen, additional, Lee, Li-Yu, additional, Lin, Chih-Hung, additional, Chen, I.-How, additional, Huang, Shiang-Fu, additional, Cheng, Ann-Joy, additional, See, Lai-Chu, additional, and Yen, Tzu-Chen, additional

Published
2009
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120. Laryngoscopic characteristics in vocal leukoplakia: Inter-rater reliability and correlation with histology grading.

Author

Young, Chi‐Kuang, Lin, Wan‐Ni, Lee, Li‐Yu, Lee, Li‐Ang, Hsin, Li‐Jen, Liao, Chun‐Ta, Li, Huesh‐Yu, Chen, I‐How, and Fang, Tuan‐Jen

Abstract

Objectives/Hypothesis Vocal cord leukoplakia is a clinical diagnosis that comprises a spectrum of benignities, premalignancies, and malignancies. Accurate recordings of the visual characteristics of the affected area are important for communication between physicians and are helpful in further management. The objective of this study was to determine the laryngoscopic characteristics among patients with vocal cord leukoplakia and the reliability of examinations between different raters. Study Design Retrospective chart review conducted in a tertiary referral center in Taiwan. Methods From January 2010 to April 2013, 107 consecutive patients with vocal leukoplakia who had accepted excisional biopsy were recruited and classified into two groups according to histologic findings. The patients without clear preoperative flexible laryngoscope images stored in the picture archiving and communication system were excluded. There were 68 patients who met the inclusion criteria, and the preoperative laryngoscope images were reviewed by two laryngologists. The inter-rater reliabilities of the recordings were assessed. Correlation between the variables and histologic classification was also performed. Results The inter-rater reliability of the assessment was significant in the recordings of color, texture, size, hyperemia, thickness, and symmetry (κ = 0.267 to 0.573, P < .05) but not in vocal cord edema. The laryngoscopic findings including color, texture, size, and hyperemia were associated with the grade of dysplasia ( P < .05). Conclusions The specific proposed laryngoscopic characteristics are consistent in the recordings between raters and can be potentially used for stratifying patients' risk. Level of Evidence 4. Laryngoscope, 125:E62-E66, 2015 [ABSTRACT FROM AUTHOR]

Published
2015
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121. The role of elective neck dissection in early stage buccal cancer.

Author

Huang, Shiang‐Fu, Tung‐Chieh Chang, Joseph, Liao, Chun‐Ta, Kang, Chung‐Jan, Lin, Chien‐Yu, Fan, Kang‐Hsing, Wang, Hung‐Ming, and Chen, I‐How

Abstract

Objectives/Hypothesis The benefits of elective neck dissection (END) in early-stage tongue cancer have been widely discussed but are still controversial regarding early-stage buccal cancer. In this study, we evaluate the role of END and the treatment outcome in early-stage buccal cancer in an areca-quid endemic area. Study Design Retrospective case-control study. Methods One hundred seventy-three cT1-2N0M0 buccal cancer patients all staged by computed tomography or magnetic resonance imaging were recruited. A total of 151 patients received radical surgery with END, whereas 22 received observation (OBS). Adjuvant radiotherapy with or without chemotherapy was given in selected high-risk patients. Results The 5-year overall survival (OS) rates for cT1 lesions and cT2 lesions were 86.14% and 75.45%, respectively ( P = .105). In the END group, the occult metastasis rate was 1.8% for cT1 lesions and 10.6% for cT2 lesions ( P = .053). The 5-year neck control rate rates ( P = .001) and disease-free survival rates ( P = .0101) were significantly better in the END group compared to the OBS group but were not significant in OS ( P = .689). Eighteen (10.41%) patients developed a second primary tumor (SPT), and five (2.89%) patients developed a third primary tumor. Ninety-four percent of SPTs were located within the oral cavity. Conclusions END was suggested in T1-T2N0 buccal cancer to improve the neck control rate. In patients for whom END is not performed at the time of tumor excision, regular follow-up of neck status is necessary because the metastatic lesions are mostly salvageable and do not influence the OS. Level of Evidence 4 Laryngoscope, 125:128-133, 2015 [ABSTRACT FROM AUTHOR]

Published
2015
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123. Genes Involved in DNA Repair and Nitrosamine Metabolism and Those Located on Chromosome 14q32 Are Dysregulated in Nasopharyngeal Carcinoma

Author

Dodd, Lori E., primary, Sengupta, Srikumar, additional, Chen, I-How, additional, den Boon, Johan A., additional, Cheng, Yu-Juen, additional, Westra, William, additional, Newton, Michael A., additional, Mittl, Beth F., additional, McShane, Lisa, additional, Chen, Chien-Jen, additional, Ahlquist, Paul, additional, and Hildesheim, Allan, additional

Published
2006
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124. Genome-Wide Expression Profiling Reveals EBV-Associated Inhibition of MHC Class I Expression in Nasopharyngeal Carcinoma

Author

Sengupta, Srikumar, primary, den Boon, Johan A., additional, Chen, I-How, additional, Newton, Michael A., additional, Dahl, David B., additional, Chen, Meng, additional, Cheng, Yu-Juen, additional, Westra, William H., additional, Chen, Chien-Jen, additional, Hildesheim, Allan, additional, Sugden, Bill, additional, and Ahlquist, Paul, additional

Published
2006
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125. 18F-FDG-PET for evaluation of the response to concurrent chemoradiation therapy with intensity-modulated radiation technique for Stage T4 nasopharyngeal carcinoma

Author

Yen, Tzu-Chen, primary, Lin, Chien-Yu, additional, Wang, Hung-Ming, additional, Huang, Shiang-Fu, additional, Liao, Chun-Ta, additional, Kang, Chung-Jan, additional, Ng, Shu-Hang, additional, Chan, Sheng-Chieh, additional, Fan, Kang-Hsing, additional, Chen, I.-How, additional, Lin, Wuu-Jyh, additional, Cheng, Ann-Joy, additional, and Chang, Joseph Tung-Chieh, additional

Published
2006
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131. Identification of differentially expressed genes in oral squamous cell carcinoma (OSCC): Overexpression of NPM, CDK1 and NDRG1 and underexpression of CHES1

Author

Chang, Joseph T., primary, Wang, Hung-Ming, additional, Chang, Ku-Wei, additional, Chen, Wen-Ho, additional, Wen, Ming-Chun, additional, Hsu, Yuan-Ming, additional, Yung, Benjamin Yat-Ming, additional, Chen, I-How, additional, Liao, Chun-Ta, additional, Hsieh, Ling-Ling, additional, and Cheng, Ann-Joy, additional

Published
2005
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136. Epstein-Barr virus seroreactivity among unaffected individuals within high-risk nasopharyngeal carcinoma families in Taiwan

Author

Pickard, Amy, primary, Chen, Chien-Jen, additional, Diehl, Scott R., additional, Liu, Mei-Ying, additional, Cheng, Yu-Juen, additional, Hsu, Wan-Lun, additional, Sun, Brenda, additional, Hsu, Mow-Ming, additional, Chen, I-How, additional, Chen, Jen-Yang, additional, Yang, Czau-Siung, additional, Mittl, Beth L., additional, Chou, Sheng-Ping, additional, Ruggles, Deborah D., additional, Goldstein, Alisa M., additional, and Hildesheim, Allan, additional

Published
2004
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140. Cisplatin, tegafur, and leucovorin

Author

Wang, Hung-Ming, primary, Wang, Cheng-Su, additional, Chen, Jen-Shi, additional, Chen, I-How, additional, Liao, Chun-Ta, additional, and Chang, Tung-Chieh Joseph, additional

Published
2002
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148. Locally recurrent nasopharyngeal carcinoma

Author

Chang, Joseph Tung-Chieh, primary, See, Lai-Chu, additional, Liao, Chun-Ta, additional, Ng, Shu-Hang, additional, Wang, Cheng-Hsu, additional, Chen, I-How, additional, Tsang, Ngan-Ming, additional, Tseng, Chen-Kan, additional, Tang, Simon G, additional, and Hong, Ji-Hong, additional

Published
2000
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149. Tumor volumetry as a prognostic factor in the management of T4a laryngeal cancer.

Author

Hsin, Li‐Jen, Fang, Tuan‐Jen, Tsang, Ngan‐Ming, Chin, Shy‐Chyi, Yen, Tzu‐Chen, Li, Hsueh‐Yu, Liao, Chun‐Ta, and Chen, I‐How

Abstract

Objectives/Hypothesis The role of tumor volume in T4a laryngeal cancer remains unclear among different treatment modalities. Using tumor volumetry, we investigated the impact of primary tumor volume on this subset of patients. Study Design Retrospective cohort study of 62 T4a laryngeal cancer patients. Methods From October 2002 to September 2010, 48 patients were treated with definitive chemoradiation therapy (CRT), and 14 patients had undergone total laryngectomy. Tumor volume was calculated and was correlated with the overall survival (OS), progression-free survival (PFS), and local control rate (LCR) data of each treatment group. Results The 5-year OS, PFS, and LCR were significantly lower in the CRT group with tumor volume ≥ 15 cm3 (22.5% vs. 48.7%, P = 0.009; 32.2% vs. 64.3%, P = 0.003; 45.2% vs. 67.3%, P = 0.039). Multivariate analysis showed that tumor volume was an independent poor prognosticator for OS, PFS, and LCR in the CRT group. For tumor volume ≥ 15 cm3, total laryngectomy provided a significantly higher 5-year OS and PFS (54.5% vs. 22.5%, P = 0.039; 80.0% vs. 32.2%, P = 0.017) than for those tumors treated with definitive CRT. Conclusions Patients with T4a laryngeal cancer with primary tumor volume ≥ 15 cm3 had poorer survival outcomes after definitive CRT compared with total laryngectomy. It was also an independent poor prognosticator on LCR, PFS, and OS for those receiving definitive CRT. For patients with tumor volume ≥ 15 cm3, total laryngectomy provided a better survival outcome than definitive CRT. Level of Evidence 4. Laryngoscope, 124:1134-1140, 2014 [ABSTRACT FROM AUTHOR]

Published
2014
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