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448 results on '"Chen, Zexin"'

105. Methyl Gallate Suppresses the Migration, Invasion, and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells via the AMPK/NF-κB Signaling Pathway in vitro and in vivo

Author

Liang, Huaguo, primary, Chen, Zexin, additional, Yang, Ruihui, additional, Huang, Qingsong, additional, Chen, Hongmei, additional, Chen, Wanting, additional, Zou, Li, additional, Wei, Peng, additional, Wei, Shijie, additional, Yang, Yongxia, additional, and Zhang, Yongli, additional

Published
2022
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106. Two cycles versus three cycles of neoadjuvant sintilimab plus platinum-doublet chemotherapy in patients with resectable non-small-cell lung cancer (neoSCORE): A randomized, single center, two-arm phase II trial.

Author

Qiu, Fuming, primary, Fan, Junqiang, additional, Shao, Miner, additional, Yao, Jie, additional, Zhao, Lufeng, additional, Zhu, Ling, additional, Li, Baizhou, additional, Fu, Yanbiao, additional, Li, Lili, additional, Yang, Yunben, additional, Wang, Yunke, additional, Chen, Mengyao, additional, Xie, Wanglan, additional, Zhang, Xinyi, additional, Tu, Jinglian, additional, Chen, Xiaoke, additional, Wu, Zuqun, additional, and Chen, Zexin, additional

Published
2022
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108. Long Term Prognostic Value Of SYNTAX Score II Among Stemi Patients—A Comprehensive Result From Meta-Analysis

Author

Yu, Changjie, Xie, Qianying, Cai, Lei, Chen, Zexin, Qiu, Sheng, Yu, Changjie, Xie, Qianying, Cai, Lei, Chen, Zexin, and Qiu, Sheng

Abstract

Purpose: To assess the predictive value of SS II (SYNTAX score II) for long-term outcomes in ST-elevated myoarial infarction (STEMI) patients. Source: PubMed, EMBASE and Cochrane databases were searched up until September 24, 2021. Two investigators extracted data independently from the relevant articles. A random-effects model was conducted to combine the pooled hazard ratio (HR) or risk ratio (RR) for association between SS II and long term outcomes. Principal findings: A total of 12 articles (7,195 subjects) were included in the final meta-analyses. Analysis of nine of the articles showed that higher SS II predicted poor long term all-cause mortality among STEMI patients (pooled RRs=4.09,95%CI: 3.49-4.80). A similar association of SS II with poor long term mortality was observed when the crude HRs and adjusted HRs were pooled (crude HRs: pooled HR=1.07, 95%CI: 1.04-1.09; adjusted HRs: pooled HR=1.05, 95%CI:1.04-1.07). The STEMI patients with higher SS II also showed a higher associated with increased risk of long term major adverse cardiac events (pooled HR = 1.05, 95% CI: 1.02-1.07; pooled RR=2.28, 95%CI:2.02-2.57). A consistent association was found for heart failure among STEMI patients. Conclusion: Higher SS II predicted poor long term all-cause mortality, major adverse cardia events and heart failure among STEMI patients

Published
2022

115. High-resolution pediatric age–specific 18F-FDG PET template: a pilot study in epileptogenic focus localization

Author

Zhang, Teng, primary, Li, Yuting, additional, Zhao, Shuilin, additional, Xu, Yuanfan, additional, Zhang, Xiaohui, additional, Wu, Shuang, additional, Dou, Xiaofeng, additional, Yu, Congcong, additional, Feng, Jianhua, additional, Ding, Yao, additional, Zhu, Junming, additional, Chen, Zexin, additional, Zhang, Hong, additional, and Tian, Mei, additional

Published
2021
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116. A novel analytic approach for outcome prediction in diffuse large B-cell lymphoma by [18F]FDG PET/CT

Author

Zhang, Xiaohui, primary, Chen, Lin, additional, Jiang, Han, additional, He, Xuexin, additional, Feng, Liu, additional, Ni, Miaoqi, additional, Ma, Mindi, additional, Wang, Jing, additional, Zhang, Teng, additional, Wu, Shuang, additional, Zhou, Rui, additional, Jin, Chentao, additional, Zhang, Kai, additional, Qian, Wenbin, additional, Chen, Zexin, additional, Zhuo, Cheng, additional, Zhang, Hong, additional, and Tian, Mei, additional

Published
2021
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121. Mouse and Frog

Author

Chen Zexin, Helen Wang, Chen Zexin, and Helen Wang

Abstract

Mouse and Frog are best friends. They may be different, but they always find ways to make the most ordinary days extraordinary! Join their adventures throughout the seasons as they find the fun in every day.

Published
2023

125. First-line treatment selection with organoids of an EGFRm + TP53m stage IA1 patient with early metastatic recurrence after radical surgery and follow-up

Author

Zhongxing Bing, Huang Min, Antonio Passaro, Yadong Wang, Tomoyuki Hishida, Yang Song, Ziqi Jia, Yanyu Wang, Han Han-Zhang, Naixin Liang, Yan Yu, Lei Cao, Peng Liu, Daniel C. Christoph, Shuyang Zhang, Chen Zexin, Zhili Cao, Xiaoying Yang, Cesare Gridelli, Jinlei Song, and Shanqing Li

Subjects
Pulmonary and Respiratory Medicine, First line treatment, iMDT Corner, medicine.medical_specialty, business.industry, MEDLINE, Medicine, Radical surgery, Stage (cooking), business, Selection (genetic algorithm), Surgery
Published
2020

128. A deep learning framework for 18F-FDG PET imaging diagnosis in pediatric patients with temporal lobe epilepsy

Author

Zhang, Qinming, primary, Liao, Yi, additional, Wang, Xiawan, additional, Zhang, Teng, additional, Feng, Jianhua, additional, Deng, Jianing, additional, Shi, Kexin, additional, Chen, Lin, additional, Feng, Liu, additional, Ma, Mindi, additional, Xue, Le, additional, Hou, Haifeng, additional, Dou, Xiaofeng, additional, Yu, Congcong, additional, Ren, Lei, additional, Ding, Yao, additional, Chen, Yufei, additional, Wu, Shuang, additional, Chen, Zexin, additional, Zhang, Hong, additional, Zhuo, Cheng, additional, and Tian, Mei, additional

Published
2021
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134. AlphaTracker: A Multi-Animal Tracking and Behavioral Analysis Tool

Author

Chen, Zexin, primary, Zhang, Ruihan, additional, Eva Zhang, Yu, additional, Zhou, Haowen, additional, Fang, Hao-Shu, additional, Rock, Rachel R., additional, Bal, Aneesh, additional, Padilla-Coreano, Nancy, additional, Keyes, Laurel, additional, Tye, Kay M., additional, and Lu, Cewu, additional

Published
2020
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135. High-resolution pediatric age–specific 18F-FDG PET template: a pilot study in epileptogenic focus localization.

Author

Zhang, Teng, Li, Yuting, Zhao, Shuilin, Xu, Yuanfan, Zhang, Xiaohui, Wu, Shuang, Dou, Xiaofeng, Yu, Congcong, Feng, Jianhua, Ding, Yao, Zhu, Junming, Chen, Zexin, Zhang, Hong, and Tian, Mei

Subjects
DIAGNOSIS of epilepsy, PILOT projects, COMPUTERS in medicine, DIGITAL image processing, STATISTICS, AGE, MEDICAL care, REGRESSION analysis, RETROSPECTIVE studies, SURGICAL complications, DIAGNOSTIC imaging, RADIOPHARMACEUTICALS, POSITRON emission tomography, HEALTH care teams, DESCRIPTIVE statistics, DEOXY sugars, COMPUTED tomography, DATA analysis software, NEURORADIOLOGY
Abstract

Background: PET imaging has been widely used in diagnosis of neurological disorders; however, its application to pediatric population is limited due to lacking pediatric age–specific PET template. This study aims to develop a pediatric age–specific PET template (PAPT) and conduct a pilot study of epileptogenic focus localization in pediatric epilepsy. Methods: We recruited 130 pediatric patients with epilepsy and 102 age-matched controls who underwent 18F-FDG PET examination. High-resolution PAPT was developed by an iterative nonlinear registration-averaging optimization approach for two age ranges: 6–10 years (n = 17) and 11–18 years (n = 50), respectively. Spatial normalization to the PAPT was evaluated by registration similarities of 35 validation controls, followed by estimation of potential registration biases. In a pilot study, epileptogenic focus was localized by PAPT-based voxel-wise statistical analysis, compared with multi-disciplinary team (MDT) diagnosis, and validated by follow-up of patients who underwent epilepsy surgery. Furthermore, epileptogenic focus localization results were compared among three templates (PAPT, conventional adult template, and a previously reported pediatric linear template). Results: Spatial normalization to the PAPT significantly improved registration similarities (P < 0.001), and nearly eliminated regions of potential biases (< 2% of whole brain volume). The PAPT-based epileptogenic focus localization achieved a substantial agreement with MDT diagnosis (Kappa = 0.757), significantly outperforming localization based on the adult template (Kappa = 0.496) and linear template (Kappa = 0.569) (P < 0.05). The PAPT-based localization achieved the highest detection rate (89.2%) and accuracy (80.0%). In postsurgical seizure-free patients (n = 40), the PAPT-based localization also achieved a substantial agreement with resection areas (Kappa = 0.743), and the highest detection rate (95%) and accuracy (80.0%). Conclusion: The PAPT can significantly improve spatial normalization and epileptogenic focus localization in pediatric epilepsy. Future pediatric neuroimaging studies can also benefit from the unbiased spatial normalization by PAPT. Trial registration. NCT04725162: https://clinicaltrials.gov/ct2/show/NCT04725162 [ABSTRACT FROM AUTHOR]

Published
2022
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136. Optimal flow layout and current allocation for improving the thermoelectric refrigeration system based on heat current method.

Author

Hao, Junhong, Chen, Zexin, Ge, Zhihua, Sun, Jian, Du, Xiaoze, and Chen, Qun

Subjects
*THERMOELECTRIC generators, *THERMOELECTRIC conversion, *HEAT convection, *THERMOELECTRIC materials, *HEAT, *ENERGY conversion, *COUNTERFLOWS (Fluid dynamics), *ENERGY transfer
Abstract

Summary: The integration analysis, modeling, and improvement of the multiple thermoelectric cooling components are significant for promoting thermoelectric cooling technology. Based on the heat current method, this paper studied a single thermoelectric cooling component and constructed its equivalent circuit model by integrating the coupled thermoelectric conduction and conversion processes with the convective heat transfer processes of both the hot side and cold side. The equivalent circuit model is used to build system‐level energy transfer and conversion models of the thermoelectric refrigeration systems with parallel‐flow, counter‐flow, and cross‐flow layouts. On this basis, the corresponding calculation process is provided by combining with the Gauss‐Seidel Algorithm based on MATLAB software. The simulation results show that the cooling capacity and coefficient of performance under the counter‐flow layout are the maximum, and the average end temperature difference is the minimum when the working current is uniform. Besides, the reasonable non‐uniform working current allocation can effectively improve the cooling capacity of the thermoelectric refrigeration system by 6.6%, 32.3%, and 1.7%, respectively. Finally, experimental results verify that the proposed heat current model of the thermoelectric cooling unit is appropriate and feasible for modeling and improving the performance by counter‐flow layout and non‐uniform working current allocation. [ABSTRACT FROM AUTHOR]

Published
2022
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137. A novel analytic approach for outcome prediction in diffuse large B-cell lymphoma by [18F]FDG PET/CT.

Author

Zhang, Xiaohui, Chen, Lin, Jiang, Han, He, Xuexin, Feng, Liu, Ni, Miaoqi, Ma, Mindi, Wang, Jing, Zhang, Teng, Wu, Shuang, Zhou, Rui, Jin, Chentao, Zhang, Kai, Qian, Wenbin, Chen, Zexin, Zhuo, Cheng, Zhang, Hong, and Tian, Mei

Subjects
B cell tumors, LYMPHOMAS, GLUCOSE metabolism, DIFFUSE large B-cell lymphomas, PROGNOSIS
Abstract

Purpose: This study aimed to develop a novel analytic approach based on 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) radiomic signature (RS) and International Prognostic Index (IPI) to predict the progression-free survival (PFS) and overall survival (OS) of patients with diffuse large B-cell lymphoma (DLBCL). Methods: We retrospectively enrolled 152 DLBCL patients and divided them into a training cohort (n = 100) and a validation cohort (n = 52). A total of 1245 radiomic features were extracted from the total metabolic tumor volume (TMTV) and the metabolic bulk volume (MBV) of pre-treatment PET/CT images. The least absolute shrinkage and selection operator (LASSO) algorithm was applied to develop the RS. Cox regression analysis was used to construct hybrid nomograms based on different RS and clinical variables. The performances of hybrid nomograms were evaluated using the time-dependent receiver operator characteristic (ROC) curve and the Hosmer–Lemeshow test. The clinical utilities of prediction nomograms were determined via decision curve analysis. The predictive efficiency of different RS, clinical variables, and hybrid nomograms was compared. Results: The RS and IPI were identified as independent predictors of PFS and OS, and were selected to construct hybrid nomograms. Both TMTV- and MBV-based hybrid nomograms had significantly higher values of area under the curve (AUC) than IPI in training and validation cohorts (all P < 0.05), while no significant difference was found between TMTV- and MBV-based hybrid nomograms (P > 0.05). The Hosmer–Lemeshow test showed that both TMTV- and MBV-based hybrid nomograms calibrated well in the training and validation cohorts (all P > 0.05). Decision curve analysis indicated that hybrid nomograms had higher net benefits than IPI. Conclusion: The hybrid nomograms combining RS with IPI could significantly improve survival prediction in DLBCL. Radiomic analysis on MBV may serve as a potential approach for prognosis assessment in DLBCL. Trial registration: NCT04317313. Registered March 16, 2020. Public site: https://clinicaltrials.gov/ct2/show/NCT04317313 [ABSTRACT FROM AUTHOR]

Published
2022
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138. A cortical-hypothalamic circuit decodes social rank and promotes dominance behavior

Author

Padilla-Coreano, Nancy, primary, Batra, Kanha, additional, Patarino, Makenzie, additional, Chen, Zexin, additional, Rock, Rachel, additional, Zhang, Ruihan, additional, Hausmann, Sebastien, additional, Weddington, Javier, additional, Patel, Reesha, additional, Zhang, Yu, additional, Fang, Hao-Shu, additional, Keyes, Laurel, additional, Libster, Avraham, additional, Matthews, Gillian, additional, Curley, James, additional, Fiete, Ila, additional, Lu, Cewu, additional, and Tye, Kay, additional

Published
2020
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141. First-line treatment selection with organoids of an EGFRm + TP53m stage IA1 patient with early metastatic recurrence after radical surgery and follow-up

Author

Jia, Ziqi, primary, Wang, Yanyu, additional, Cao, Lei, additional, Wang, Yadong, additional, Song, Yang, additional, Yang, Xiaoying, additional, Bing, Zhongxing, additional, Cao, Zhili, additional, Liu, Peng, additional, Zhang, Shuyang, additional, Chen, Zexin, additional, Huang, Min, additional, Yu, Yan, additional, Han-Zhang, Han, additional, Song, Jinlei, additional, Christoph, Daniel C., additional, Passaro, Antonio, additional, Gridelli, Cesare, additional, Hishida, Tomoyuki, additional, Liang, Naixin, additional, and Li, Shanqing, additional

Published
2020
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142. The interaction between prepregnancy BMI and gestational vitamin D deficiency on the risk of gestational diabetes mellitus subtypes with elevated fasting blood glucose

Author

Shao, Bule, primary, Mo, Minjia, additional, Xin, Xing, additional, Jiang, Wen, additional, Wu, Jinhua, additional, Huang, Manxian, additional, Wang, Shuojia, additional, Muyiduli, Xiamusiye, additional, Si, Shuting, additional, Shen, Yu, additional, Chen, Zexin, additional, and Yu, Yunxian, additional

Published
2020
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144. Vitamin D nutrient status during pregnancy and its influencing factors

Author

Shen, Yu, primary, Pu, Liuyue, additional, Si, Shuting, additional, Xin, Xing, additional, Mo, Minjia, additional, Shao, Bule, additional, Wu, Jinhua, additional, Huang, Manxian, additional, Wang, Shuojia, additional, Muyiduli, Xiamusiye, additional, Chen, Zexin, additional, Jiang, Wen, additional, and Yu, Yunxian, additional

Published
2020
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145. Prognostic impact of diabetes mellitus and index of microcirculatory resistance in patients undergoing fractional flow reserve-guided revascularization

Author

Hu, Xinyang, primary, Zhang, Jinlong, additional, Lee, Joo Myung, additional, Chen, Zexin, additional, Hwang, Doyeon, additional, Park, Jonghanne, additional, Shin, Eun-Seok, additional, Nam, Chang-Wook, additional, Doh, Joon-Hyung, additional, Chen, Shaoliang, additional, Yang, Junqing, additional, Tanaka, Nobuhiro, additional, Kuramitsu, Shoichi, additional, Matsuo, Hitoshi, additional, Takashima, Hiroaki, additional, Akasaka, Takashi, additional, Koo, Bon-Kwon, additional, and Wang, Jianan, additional

Published
2020
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146. Phosphorus influence Cd phytoextraction in Populus stems via modulating xylem development, cell wall Cd storage and antioxidant defense

Author

Yang, Can, primary, Qiu, Wenwen, additional, Chen, Zexin, additional, Chen, Wenyi, additional, Li, Yunfei, additional, Zhu, Jingle, additional, Rahman, Siddiq Ur, additional, Han, Zixuan, additional, Jiang, Yun, additional, Yang, Guijuan, additional, Tian, Jing, additional, Ma, Qin, additional, and Zhang, Yi, additional

Published
2020
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147. Brain Injury after Transcatheter Aortic Valve Replacement for Bicuspid Versus Tricuspid Aortic Valve Stenosis

Author

Fan, Jiaqi, primary, Fang, Xian, additional, Liu, Chunhui, additional, Zhu, Gangjie, additional, Hou, Cody R., additional, Jiang, Jubo, additional, Lin, Xinping, additional, Wang, Lihan, additional, He, Yuxin, additional, Zhu, Qifeng, additional, Ng, Stella, additional, Chen, Zexin, additional, Hu, Haitao, additional, Tse, Hungfat, additional, Liu, Xianbao, additional, and Wang, Jian’an, additional

Published
2020
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150. Challenges and adaptations in implementing an English-medium medical program:a case study in China

Author

Patricia S. O'Sullivan, Miao Yang, Chen Zexin, David M. Irby, Chun Lin, and Changmin Lin

Subjects
Medium of instruction, China, Students, Medical, 020205 medical informatics, lcsh:Medicine, 02 engineering and technology, Education, 03 medical and health sciences, 0302 clinical medicine, Clinical Research, Medical, ComputingMilieux_COMPUTERSANDEDUCATION, 0202 electrical engineering, electronic engineering, information engineering, Humans, Learning, Translations, Medical humanities, 030212 general & internal medicine, Challenges, Students, English as the medium of instruction, lcsh:LC8-6691, Medical education, Education, Medical, lcsh:Special aspects of education, Teaching, lcsh:R, Communication Barriers, Peer group, Problem-Based Learning, General Medicine, Focus Groups, Faculty, Focus group, Test (assessment), Quality Education, Adaptive teaching and learning strategies, Public Health and Health Services, Curriculum, Thematic analysis, Faculty development, Psychology, Curriculum and Pedagogy, Medical Informatics, Research Article, Program Evaluation, Graduation
Abstract

Background Increasingly, non-English speaking countries use English as the medium of instruction (EMI) to teach academic subjects. This study investigated the challenges and adaptation strategies of teachers and students in an EMI medical education program in China. Methods Data were collected on EMI and non-EMI students’ test performances and student and teacher perceptions of the program. Test scores and survey results were analyzed using SPSS. Focus group transcripts and open-ended comments from surveys were examined using thematic coding. Results There were no significant differences in admission and graduation test scores for EMI and non-EMI students. Four challenges with the EMI program were identified: (1) insufficient/inappropriate teaching materials, (2) unsatisfactory teaching, (3) inadequate class interactions, and (4) failure to teach medical humanities. To address these challenges, teachers and students used adaptive strategies, such as the use of alternative textbooks, self-learning skills and Chinese language. Conclusions EMI programs are difficult to initiate, requiring faculty development and institutional support, and student self and peer group learning strategies to be successful. The adaptive strategies employed by both students and teachers offer insights into how other EMI programs might strengthen their implementation.

Published
2019

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