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805 results on '"Chilosi, M"'

107. P21/WAF1 cyclin-kinase inhibitor expression in non-Hodgkin’s lymphomas and Hodgkin’s disease: a reliable marker of p53 tumor suppressor gene function

Author

Chilosi, M., Doglioni, C., Magalini, A., Scarpa, Aldo, Lestani, Maurizio, Rahal, D., Rucco, V., Morelli, Lorenzo, Krampera, Mauro, Menestrina, F., Inghirami, G., and Pizzolo, Giovanni

Subjects
P21/WAF1 cyclin-kinase inhibitor, P53, non-Hodgkin’s lymphomas, P53, P21/WAF1 cyclin-kinase inhibitor, non-Hodgkin’s lymphomas,Hodgkin’s disease, Hodgkin’s disease
Published
1996

112. Idiopathic nonspecific interstitial pneumonia: an interstitial lung disease associated with autoimmune disorders?

Author

Romagnoli, M., primary, Nannini, C., additional, Piciucchi, S., additional, Girelli, F., additional, Gurioli, C., additional, Casoni, G., additional, Ravaglia, C., additional, Tomassetti, S., additional, Gavelli, G., additional, Carloni, A., additional, Dubini, A., additional, Cantini, F., additional, Chilosi, M., additional, and Poletti, V., additional

Published
2011
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113. Soluble forms of p55-IL-2R alpha, CD8, and CD30 molecules as markers of lymphoid cell activation in infectious mononucleosis

Author

Vinante, F, Morosato, L, Siviero, F, Nadali, G, Rigo, A, Veneri, D, de Sabata, D, Vincenzi, C, Chilosi, M, and Semenzato, GIANPIETRO CARLO

Subjects
Adult, Adolescent, Solubility, CD8 Antigens, Humans, Ki-1 Antigen, Receptors, Interleukin-2, Infectious Mononucleosis, Lymphocyte Activation, Biomarkers, Follow-Up Studies
Abstract

Epstein-Barr virus (EBV) infection in infectious mononucleosis (IM) is associated with lymphocyte activation leading to the expansion of cells expressing activation-associated antigens. Most of these antigens are released as soluble molecules in vitro and in vivo.We investigated the serum levels of the soluble forms of the CD8 (sCD8), p55-IL-2R alpha (sIL-2R alpha), and CD30 (sCD30) molecules in 55 patients following primary EBV infection. These data were compared with the phenotypic pattern of circulating lymphoid subsets.In all cases at presentation, lymphocytosis, mainly characterized by the expansion of a CD8+, HLA-DR+, p75-IL-2R beta+, p55-IL-2R alpha- population, was associated with high levels of the investigated soluble molecules. Their mean values (+/- SD) were: 17,172 +/- 12,885 U/mL for sCD8 (vs 334 +/- 95 in controls), 2,922 +/- 2,813 U/mL for sIL-2R alpha (vs 331 +/- 115 in controls), and 477 +/- 451 U/mL for sCD30 (vs 4.9 +/- 6.4 in controls). Follow-up study (15 cases, up to 60 days) showed a progressive decline of all soluble molecules, associated with a reduction of activated CD8+/HLA-DR+/p75-IL-2R beta+ T-cells. By the 30th day, values of sIL-2R alpha and sCD30 (729 +/- 333 U/mL and 20 +/- 21 U/mL, respectively) were only slightly higher than in normal controls, whereas sCD8 levels remained consistently higher (1,777 +/- 1,385 U/mL, p.001).sCD8, sIL-2Ra and sCD30 serum levels in IM reflect the total bulk and/or the activation-related events of infected and reactive cells. The variations in these soluble molecules during the follow-up provide useful information on the in vivo biological modifications occurring after EBV infection.

Published
1994

123. Constitutive expression of tenascin in T-dependent zones of human lymphoid tissues

Author

Chilosi, M., Lestani, M., Benedetti, A., Montagna, L., Pedron, S., Aldo Scarpa, Menestrina, F., Hirohashi, S., Pizzolo, G., and Semenzato, G.

Subjects
endocrine system, Extracellular Matrix Proteins, animal structures, bone marrow, Cell Adhesion Molecules, Neuronal, tenascin, Immunohistochemistry, Lymph Nodes, Thymus, Thymus Gland, musculoskeletal system, T-Lymphocyte Subsets, embryonic structures, Humans, Lymphatic Diseases, Research Article
Abstract

Tenascin is a major extracellular matrix glycoprotein that can interfere with the action of fibronectin by inhibiting cell adhesion and spreading. Although tenascin is able to exert important immunomodulatory activities on T and B cells and macrophages, little is known about its distribution in different lymphohemopoietic tissues. In this study we have analyzed tenascin immunoreactivity on cryostat and paraffin sections of normal and pathological lymphoid tissues using two different monoclonal antibodies. We demonstrated strong tenascin expression in all peripheral lymphoid tissues, whereas it was barely detectable in the thymus and in bone marrow. In reactive lymph nodes, tenascin was mainly found in T-dependent zones, forming a variably close-woven reticular network corresponding to fibroblastic reticulum cells and blood vessels basal laminae, showing a partial co-localization with fibronectin. In B-dependent zones, tenascin was restricted to blood vessels. Using double-marker analysis, we performed a thorough study comparing tenascin expression in different compartments of lymphoid microenvironments. Tenascin network appeared much thicker in chronically stimulated tissues, where CD4+ lymphocytes with "memory" phenotype (CD45RO+/CD45RA-) were predominant, and at sites of ongoing inflammation. In particular, a striking increase of tenascin was observed in sarcoid lymph node, as well as in myasthenic hyperplastic thymuses. In addition, tenascin can be abnormally synthesized in tissue involved by various types of lymphomas, including Hodgkin's disease and hairy cell leukemia.

Published
1993

126. Transbronchial biopsy in sarcoidosis: the role of immunohistochemical analysis for granuloma detection

Author

Menestrina, F., Lestani, M., Mombello, A., Cipriani, A., Pomponi, F., Adami, F., Gianpietro Semenzato, and Chilosi, M.

Subjects
Lung Diseases, Granuloma, Biopsy, Antigens, Differentiation, Myelomonocytic, Reproducibility of Results, Immunohistochemistry, Sensitivity and Specificity, Sarcoidosis, Pulmonary, Antigens, CD, Humans, Keratins, Leukocyte Common Antigens, Collagen, Lung
Abstract

In this study 27 transbronchial biopsy specimens obtained from patients with clinical and/or laboratory features suggestive for sarcoidosis were analysed with conventional morphology and immunohistochemistry comparing the sensitivity and reproducibility of the two methods. A limited panel of monoclonal antibodies recognizing epitopes resistant to conventional fixation and embedment procedures were used (CD45R0, CD68, anti-cheratin, anti-collagen IV). All specimens were independently observed by two different pathologists. On the basis of the recognition of bona-fide noncaseating granulomas, 9 cases were uniformly judged as positive, 10 cases as negative, but 8 cases were considered doubtful. Immunohistochemical analysis reliably demonstrated the presence of epithelioid cells in 3 of these cases and absence in 5. These data suggest that the use of a limited immunohistochemical analysis can significantly improve histological diagnosis of sarcoidosis on small transbronchial biopsies using conventional routine material.

Published
1992

130. Evidence of c-myc gene abnormalities in mediastinal large B-cell lymphoma of young adult age

Author

Aldo Scarpa, Borgato, L., Chilosi, M., Capelli, P., Menestrina, F., Bonetti, F., Zamboni, G., Pizzolo, G., Hirohashi, S., and Fiore-Donati, L.

Subjects
Neoplasm/genetics/isolation & purification Doxorubicin/administration & dosage Female Gene Rearrangement *Genes, Combined Modality Therapy Cyclophosphamide/administration & dosage DNA Probes DNA, myc Human Leucovorin/administration & dosage Lymphoma, B-Cell/drug therapy/*genetics/therapy
Published
1991

131. ZAP-70 expression, as detected by immunohistochemistry on bone marrow biopsies from early-phase CLL patients, is a strong adverse prognostic factor

Author

Zanotti, R, primary, Ambrosetti, A, additional, Lestani, M, additional, Ghia, P, additional, Pattaro, C, additional, Remo, A, additional, Zanetti, F, additional, Stella, S, additional, Perbellini, O, additional, Prato, G, additional, Guida, G, additional, Caligaris-Cappio, F, additional, Menestrina, F, additional, Pizzolo, G, additional, and Chilosi, M, additional

Published
2006
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142. p21/WAF1 cyclin-kinase inhibitor expression in non-Hodgkin's lymphomas: a potential marker of p53 tumor-suppressor gene function

Author

Chilosi, M, primary, Doglioni, C, additional, Magalini, A, additional, Inghirami, G, additional, Krampera, M, additional, Nadali, G, additional, Rahal, D, additional, Pedron, S, additional, Benedetti, A, additional, Scardoni, M, additional, Macri, E, additional, Lestani, M, additional, Menestrina, F, additional, Pizzolo, G, additional, and Scarpa, A, additional

Published
1996
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143. Molecular characterization of the t(2;5) (p23; q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease

Author

Yee, HT, primary, Ponzoni, M, additional, Merson, A, additional, Goldstein, M, additional, Scarpa, A, additional, Chilosi, M, additional, Menestrina, F, additional, Pittaluga, S, additional, de Wolf-Peeters, C, additional, Shiota, M, additional, Mori, S, additional, Frizzera, G, additional, and Inghirami, G, additional

Published
1996
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