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737 results on '"Coppola, L. A."'

103. The Influence of Heat and Steam Curing on the Properties of One-Part Fly Ash/Slag Alkali Activated Materials: Preliminary results.

Author

Coppola, L., Coffetti, D., Crotti, E., Dell’Aversano, R., and Gazzaniga, G.

Subjects
*FLY ash, *SLAG, *SOLUBLE glass, *HEAT, *POTASSIUM hydroxide, *SODIUM hydroxide, *MORTAR
Abstract

This paper presents the preliminary results of an experimental research on the influence of heat and steam curing on the performances of one-part alkali-activated mortars based on low calcium fly ash (FA) and ground granulated blast furnace slag (GGBFS) with different GGBFS/FA ratios. The mortars were manufactured at equal water to precursor ratio and were activated by sodium silicate, potassium hydroxide and sodium carbonate in powder form. In general, by growing the GGBFS/FA ratio, the workability of fresh mortars decreases and the elasto-mechanical performance increases, independently of curing conditions. The heat and/or steam curing temperatures equal to 40°C or 60°C promote the development of higher early compressive strength respect to standard curing conditions (20°C), especially at high GGBFS/FA ratios, while no advantages were detected at longer ages. [ABSTRACT FROM AUTHOR]

Published
2019
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105. Programmed Cell Death Ligand-1 (PD-L1) Expression is Coupled with Microsatellite Instability in Non-Familial Small Bowel Carcinomas Associated or not with Coeliac Disease or Crohn's Disease: Results from the Small Bowel Cancer Italian Consortium

Author

Vanoli, A., Giuffrida, P., Martino, M., Persichella, A., Viglio, A., Furlan, D., Klersy, C., Grillo, F., Fiocca, R., Mescoli, C., Rugge, M., Nesi, G., Fociani, P., Sampietro, G., Ardizzone, S., Luinetti, O., Calabro, A., Tonelli, F., Volta, U., Santini, D., Giacomo Caio, Elli, L., Ferrero, S., Latella, G., Ciardi, A., Caronna, R., Solina, G., Rizzo, A. G., Ciacci, C., D Armiento, F. P., Salemme, M., Villanacci, V., Cannizzaro, R., Canzonieri, V., Bonetti, L. Reggiani, Biancone, L., Monteleone, G., Orlandi, A., Santeusanio, G., Macciomei, M., D Inca, R., Perfetti, V., Sandri, G., Silano, M., Florena, A., Giannone, A., Papi, C., Coppola, L., Usai, P., Maccioni, A., Astegiano, M., Migliora, P., Sessa, F., Solcia, E., Corazza, G. R., Paulli, M., and Di Sabatino, A.

Subjects
NO
Published
2018

106. Global in-situ imaging of large plankton and particles by the Underwater Vision Profiler in the upper kilometer of all oceans

Author

Stemmann, L., Lombard, F., Guidi, L, Coppola, L., Irisson, J.O., Picheral, M., Lafond, A., Waite, A., Biard, T., Boss, E., Hauss, H., Mcdonnell, A., Babin, M., Ohman, M., Kiko, R., Gorsky, G., Laboratoire d'océanographie de Villefranche (LOV), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de la Mer de Villefranche (IMEV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut des Matériaux Jean Rouxel (IMN), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Service de Chimie des Procédés de Séparation (SCPS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Takuvik Joint International Laboratory ULAVAL-CNRS, and Université Laval [Québec] (ULaval)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography
Abstract

International audience

Published
2018

110. Endocrine Pancreas in Cats With Diabetes Mellitus

Author

Zini, Eric, Lunardi, F, Zanetti, R, Heller, R S, Coppola, L M, Ferro, S, Guscetti, Franco, Osto, Melania, Lutz, Thomas A, Reusch, Claudia E, Cavicchioli, L, University of Zurich, and Zini, Eric

Subjects
islets, Male, endocrine system, 10253 Department of Small Animals, General Veterinary, 3400 General Veterinary, amyloid, cat, 10184 Institute of Veterinary Pathology, Amyloidosis, 10081 Institute of Veterinary Physiology, Cat Diseases, Glucagon, Islet Amyloid Polypeptide, Islets of Langerhans, Cats, Diabetes Mellitus, 570 Life sciences, biology, Animals, Insulin, pathology, Female, diabetes mellitus, pancreas, Pancreas
Abstract

Pancreatic amyloidosis and loss of α and β cells have been shown to occur in cats with diabetes mellitus, although the number of studies currently available is very limited. Furthermore, it is not known whether pancreatic islet inflammation is a common feature. The aims of the present study were to characterize islet lesions and to investigate whether diabetic cats have inflammation of the pancreatic islets. Samples of pancreas were collected postmortem from 37 diabetic and 20 control cats matched for age, sex, breed, and body weight. Histologic sections were stained with hematoxylin and eosin and Congo red; double labeled for insulin/CD3, insulin/CD20, insulin/myeloperoxidase, insulin/proliferating cell nuclear antigen, and glucagon/Ki67; and single labeled for amylin and Iba1. Mean insulin-positive cross-sectional area was approximately 65% lower in diabetic than control cats ( P = .009), while that of amylin and glucagon was similar. Surprisingly, amyloid deposition was similar between groups ( P = .408). Proliferation of insulin- and glucagon-positive cells and the number of neutrophils, macrophages, and T (CD3) and B (CD20) lymphocytes in the islets did not differ. The presence of T and B lymphocytes combined tended to be more frequent in diabetic cats ( n = 8 of 37; 21.6%) than control cats ( n = 1 of 20; 5.0%). The results confirm previous observations that loss of β cells but not α cells occurs in diabetic cats. Islet amyloidosis was present in diabetic cats but was not greater than in controls. A subset of diabetic cats had lymphocytic infiltration of the islets, which might be associated with β-cell loss.

Published
2015

111. Multi-scale observations of deep convection in the northwestern Mediterranean Sea during winter 2012-2013 using multiple platforms

Author

Testor, Pierre, Bosse, A., Houpert, L., Margirier, F., Mortier, L., Legoff, H., Dausse, D., Labaste, M., Karstensen, Johannes, Hayes, D., Olita, A., Ribotti, A., Schroeder, K., Chiggiato, J., Onken, R., Mourre, B., Heslop, E., D'Ortenzio, F., Mayot, N., Lavigne, H., de Fommervault, O., Coppola, L., Prieur, L., Taillandier, V., Durrieu de Madron, X., Bourrin, G., Many, G., Damien, P., Estournel, C., Marsaleix, P., Taupier-Letage, I., Raimbault, P., Waldman, R., Bouin, M.-N., Giordani, H., Caniaux, G., Somot, S., Ducrocq, V., Conan, P., Testor, Pierre, Bosse, A., Houpert, L., Margirier, F., Mortier, L., Legoff, H., Dausse, D., Labaste, M., Karstensen, Johannes, Hayes, D., Olita, A., Ribotti, A., Schroeder, K., Chiggiato, J., Onken, R., Mourre, B., Heslop, E., D'Ortenzio, F., Mayot, N., Lavigne, H., de Fommervault, O., Coppola, L., Prieur, L., Taillandier, V., Durrieu de Madron, X., Bourrin, G., Many, G., Damien, P., Estournel, C., Marsaleix, P., Taupier-Letage, I., Raimbault, P., Waldman, R., Bouin, M.-N., Giordani, H., Caniaux, G., Somot, S., Ducrocq, V., and Conan, P.

Published
2018
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113. Small bowel carcinomas in celiac or Crohn's disease: Distinctive histophenotypic, molecular and histogenetic patterns

Author

Vanoli, A., Di Sabatino, A., Martino, M., Klersy, C., Grillo, F., Mescoli, C., Nesi, G., Volta, U., Fornino, D., Luinetti, O., Fociani, P., Villanacci, V., D'Armiento, F. P., Cannizzaro, R., Latella, G., Ciacci, C., Biancone, L., Paulli, M., Sessa, F., Rugge, M., Fiocca, R., Corazza, G. R., Solcia, E., Ardizzone, S., Astegiano, M., Caio, G., Calabro, A., Canzonieri, V., Cerutti, R., Ciardi, A., Coppola, L., D'Inca, R., Elli, L., Ferrero, S., Florena, A. M., Furlan, D., Giannone, A. G., Giuffrida, P., Macciomei, M. C., Maccioni, A., Monteleone, G., Migliora, P., Orlandi, A., Papi, C., Perfetti, V., Bonetti, L. R., Rizzo, A., Salemme, M., Sandri, G., Sampietro, G., Santeusanio, G., Santini, D., Silano, M., Solina, G., Tonelli, F., Trapani, D., Usai, P., Vanoli, Alessandro, Di Sabatino, Antonio, Martino, Michele, Klersy, Catherine, Grillo, Federica, Mescoli, Claudia, Nesi, Gabriella, Volta, Umberto, Fornino, Daniele, Luinetti, Ombretta, Fociani, Paolo, Villanacci, Vincenzo, D'Armiento, Francesco P., Cannizzaro, Renato, Latella, Giovanni, Ciacci, Carolina, Biancone, Livia, Paulli, Marco, Sessa, Fausto, Rugge, Massimo, Fiocca, Roberto, Corazza, Gino R., Solcia, Enrico, D'Armiento, Francesco P, and Corazza, Gino R

Subjects
0301 basic medicine, Adult, Male, medicine.medical_specialty, Pathology, small bowel carcinoma, celiac disease, immunology, gastrointestinal cancer, Kaplan-Meier Estimate, Histogenesis, Biology, Small, Gastroenterology, Pathology and Forensic Medicine, NO, Surgical pathology, immunology, inflammatory bowel disease, 03 medical and health sciences, small bowel carcinoma, 0302 clinical medicine, Crohn Disease, Internal medicine, Intestine, Small, Intestinal Neoplasms, medicine, Carcinoma, Humans, 2734 small bowel carcinoma, coeliac disease, Crohn's disease, Proportional Hazards Models, Retrospective Studies, Crohn's disease, Settore MED/12 - Gastroenterologia, Celiac Disease, Female, Middle Aged, Microsatellite instability, Anatomical pathology, medicine.disease, digestive system diseases, Intestine, 030104 developmental biology, Dysplasia, 030220 oncology & carcinogenesis, Hematopathology, celiac disease
Abstract

Non-familial small bowel carcinomas are relatively rare and have a poor prognosis. Two small bowel carcinoma subsets may arise in distinct immune-inflammatory diseases (celiac disease and Crohn's disease) and have been recently suggested to differ in prognosis, celiac disease-associated carcinoma cases showing a better outcome, possibly due to their higher DNA microsatellite instability and tumor-infiltrating T lymphocytes. In this study, we investigated the histological structure (glandular vs diffuse/poorly cohesive, mixed or solid), cell phenotype (intestinal vs gastric/pancreatobiliary duct type) and Wnt signaling activation (beta-catenin and/or SOX-9 nuclear expression) in a series of 26 celiac disease-associated small bowel carcinoma, 25 Crohn's disease-associated small bowel carcinoma and 25 sporadic small bowel carcinoma cases, searching for new prognostic parameters. In addition, non-tumor mucosa of celiac and Crohn's disease patients was investigated for epithelial precursor changes (hyperplastic, metaplastic or dysplastic) to help clarify carcinoma histogenesis. When compared with non-glandular structure and non-intestinal phenotype, both glandular structure and intestinal phenotype were associated with a more favorable outcome at univariable or stage-and microsatellite instability/tumor-infiltrating lymphocyte-inclusive multivariable analysis. The prognostic power of histological structure was independent of the clinical groups while the non-intestinal phenotype, associated with poor outcome, was dominant among Crohn's disease-associated carcinoma. Both nuclear beta-catenin and SOX-9 were preferably expressed among celiac disease-associated carcinomas; however, they were devoid, per se, of prognostic value. We obtained findings supporting an origin of celiac disease-associated carcinoma in SOX-9-positive immature hyperplastic crypts, partly through flat beta-catenin-positive dysplasia, and of Crohn's disease-associated carcinoma in a metaplastic (gastric and/or pancreatobiliary-type) mucosa, often through dysplastic polypoid growths of metaplastic phenotype. In conclusion, despite their common origin in a chronically inflamed mucosa, celiac disease-associated and Crohn's disease-associated small bowel carcinomas differ substantially in histological structure, phenotype, microsatellite instability/tumor-infiltrating lymphocyte status, Wnt pathway activation, mucosal precursor lesions and prognosis.

Published
2017

114. Observation of oxygen ventilation into deep waters through targeted deployment of multiple Argo-O2 floats in the north-western Mediterranean Sea in 2013

Author

Coppola, L., Prieur, L., Taupier-Letage, I., Estournel, C., Testor, P., Lefevre, D., Belamari, S., LeReste, S., Taillandier, V., Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'aérologie (LAERO), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Variabilité de l'Océan et de la Glace de mer (VOG), Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques (LOCEAN), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre national de recherches météorologiques (CNRM), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), GMMC, MerMex (Marine Ecosystem Response in the Mediterranean Experiment), HyMeX (Hydrological cycle in the Mediterranean EXperiment), MISTRALS, ANR-12-BS06-0003,ASICS-MED,Couplage Océan-Atmosphère en présence de structures de Submésoéchelle(2012), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Groupe d'étude de l'atmosphère météorologique (CNRM-GAME), Institut national des sciences de l'Univers (INSU - CNRS)-Météo France-Centre National de la Recherche Scientifique (CNRS), Institut Français de Recherche pour l'Exploitation de la Mer - Brest (IFREMER Centre de Bretagne), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulon (UTLN), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), and Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0106 biological sciences, Convection, Biogeochemical cycle, 010504 meteorology & atmospheric sciences, Mixed layer, dense water formation, [PHYS.PHYS.PHYS-GEO-PH]Physics [physics]/Physics [physics]/Geophysics [physics.geo-ph], Structural basin, Oceanography, 01 natural sciences, Mediterranean sea, Geochemistry and Petrology, Earth and Planetary Sciences (miscellaneous), Argo floats, 14. Life underwater, Argo, [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography, 0105 earth and related environmental sciences, 010604 marine biology & hydrobiology, north-western Mediterranean Sea, Geophysics, 13. Climate action, Space and Planetary Science, deep water ventilation, dissolved oxygen, Submarine pipeline, Thermohaline circulation, Geology
Abstract

International audience; During the winter 2013, an intense observation and monitoring was performed in the north-western Mediterranean Sea to study deep water formation process that drives thermohaline circulation and biogeochemical processes (HYMEX SOP2 and DEWEX projects). To observe intensively and continuously the impact of deep convection on oxygen (O2) ventilation, an observation strategy was based on the enhancement of the Argo-O2 floats to monitor the offshore dense water formation area (DWF) in the Gulf of Lion prior to and at the end of the convective period (December 2012 to April 2013). The intense O2 measurements performed through shipborne CTD casts and Argo-O2 floats deployment revealed an O2 inventory rapidly impacted by mixed layer (ML) deepening on the month scale. The open-sea convection in winter 2013 ventilated the deep waters from mid-February to the end of May 2013. The newly ventilated dense water volume, based on an Apparent Oxygen Utilization (AOU) threshold, was estimated to be about 1.5 × 1013 m3 during the DWF episode, increasing the deep O22 concentrations from 196 to 205 µmol kg−1 in the north-western basin.

Published
2017

115. Varicocele negatively affects sperm mitochondrial respiration

Author

FERRAMOSCA, Alessandra, Albani D, Coppola L, ZARA, Vincenzo, Ferramosca, Alessandra, Albani, D, Coppola, L, and Zara, Vincenzo

Subjects
varicocele, mitochondria, oxidative stre, urogenital system, spermatozoa
Abstract

OBJECTIVE: To evaluate the effect of varicocele on oxidative stress, sperm mitochondrial respiratory efficiency, sperm morphology and semen parameters. METHODS: 20 patients with varicocele and 20 normozoospermic subjects without varicocele (control group) were recruited from a medical center for reproductive biology. The levels of serum reactive oxygen metabolites and seminal lipid peroxides were assessed for both control and varicocele subjects. Sperm DNA fragmentation was measured by sperm chromatin dispersion test. Mitochondrial respiratory activity was evaluated with a polarographic assay of oxygen consumption carried out in hypotonically-treated sperm cells. RESULTS: In this study, varicocele patients were compared with men without varicoceles. Oxidative stress was observed in the serum and seminal fluid of varicocele patients. These patients showed an increase of 59% (P < 0.05) in serum reactive oxygen metabolites and a threefold increase in the level of sperm lipid peroxides. A parallel and significant increase (a twofold increase; P < 0.05) in the degree of sperm DNA fragmentation was also observed. Varicocele patients showed a 27% decrease (P < 0.05) in mitochondrial respiratory activity in comparison to the control group. A 32% increase (P < 0.05) in sperm midpiece defects and a 41% decrease (P < 0.05) in sperm concentration and motility were also observed. CONCLUSIONS: Men with varicocele have increased markers of oxidative stress and decreased mitochondrial respiratory activity. These results correlated with abnormalities in semen parameters. For morphology these correlated with midpiece defects.

Published
2015

117. Real world adherence to Direct-Acting Antivirals in a cohort of drug users in Rome, Italy

Author

Teti, E., primary, Foroghi, L., additional, Malagnino, V., additional, Cento, V., additional, Stingone, C., additional, Compagno, M., additional, Malerba, G., additional, Gentile, A., additional, Cavasio, R.A., additional, Coppola, L., additional, Rossi, E., additional, Masci, D., additional, Sammarco, P., additional, Coladarce, B., additional, Rodoquino, G., additional, Patti, M., additional, Sarrecchia, C., additional, Perno, C.F., additional, Silberstein, F.C., additional, Barra, M., additional, Sarmati, L., additional, and Andreoni, M., additional

Published
2018
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118. OC.11.1 PROGRAMMED CELL DEATH LIGAND-1 (PD-L1) EXPRESSION IS COUPLED WITH MICROSATELLITE INSTABILITY IN NON-FAMILIAL SMALL BOWEL CARCINOMAS ASSOCIATED OR NOT WITH COELIAC DISEASE OR CROHN'S DISEASE: RESULTS FROM THE SMALL BOWEL CANCER ITALIAN CONSORTIUM

Author

Vanoli, A., primary, Giuffrida, P., additional, Martino, M., additional, Persichella, A., additional, Viglio, A., additional, Furlan, D., additional, Klersy, C., additional, Grillo, F., additional, Fiocca, R., additional, Mescoli, C., additional, Rugge, M., additional, Nesi, G., additional, Fociani, P., additional, Sampietro, G., additional, Ardizzone, S., additional, Luinetti, O., additional, Calabrò, A., additional, Tonelli, F., additional, Volta, U., additional, Santini, D., additional, Caio, G., additional, Elli, L., additional, Ferrero, S., additional, Latella, G., additional, Ciardi, A., additional, Caronna, R., additional, Solina, G., additional, Rizzo, A.G., additional, Ciacci, C., additional, D'Armiento, F.P., additional, Salemme, M., additional, Villanacci, V., additional, Cannizzaro, R., additional, Canzonieri, V., additional, Bonetti, L. Reggiani, additional, Biancone, L., additional, Monteleone, G., additional, Orlandi, A., additional, Santeusanio, G., additional, Macciomei, M., additional, D'Incà, R., additional, Perfetti, V., additional, Sandri, G., additional, Silano, M., additional, Florena, A., additional, Giannone, A., additional, Papi, C., additional, Coppola, L., additional, Usai, P., additional, Maccioni, A., additional, Astegiano, M., additional, Migliora, P., additional, Sessa, F., additional, Solcia, E., additional, Corazza, G.R., additional, Paulli, M., additional, and Di Sabatino, A., additional

Published
2018
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119. Observation of oxygen ventilation into deep waters through targeted deployment of multiple Argo-O 2 floats in the north-western Mediterranean Sea in 2013

Author

Coppola, L., Prieur, L., Taupier-letage, I., Estournel, C., Testor, P., Lefevre, D., Belamari, S., Le Reste, Serge, Taillandier, V., Coppola, L., Prieur, L., Taupier-letage, I., Estournel, C., Testor, P., Lefevre, D., Belamari, S., Le Reste, Serge, and Taillandier, V.

Abstract

During the winter 2013, an intense observation and monitoring was performed in the north-western Mediterranean Sea to study deep water formation process that drives thermohaline circulation and biogeochemical processes (HYMEX SOP2 and DEWEX projects). To observe intensively and continuously the impact of deep convection on oxygen (O2) ventilation, an observation strategy was based on the enhancement of the Argo-O2 floats to monitor the offshore dense water formation area (DWF) in the Gulf of Lion prior to and at the end of the convective period (December 2012 to April 2013). The intense O2 measurements performed through shipborne CTD casts and Argo-O2 floats deployment revealed an O2 inventory rapidly impacted by mixed layer (ML) deepening on the month scale. The open-sea convection in winter 2013 ventilated the deep waters from mid-February to the end of May 2013. The newly ventilated dense water volume, based on an Apparent Oxygen Utilization (AOU) threshold, was estimated to be about 1.5 × 1013 m3 during the DWF episode, increasing the deep O2 concentrations from 196 to 205 µmol kg−1 in the north-western basin.

Published
2017
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120. Splenitis in 33 dogs

Author

Ferri, F, Zini, Eric; https://orcid.org/0000-0002-7580-1297, Auriemma, E, Castagnaro, M, Coppola, L M, Peano, A, Martella, V, Decaro, N, Kuhnert, P, Ferro, S, Ferri, F, Zini, Eric; https://orcid.org/0000-0002-7580-1297, Auriemma, E, Castagnaro, M, Coppola, L M, Peano, A, Martella, V, Decaro, N, Kuhnert, P, and Ferro, S

Abstract

Splenitis is uncommonly reported in dogs. Herein, the authors describe its prevalence, clinical findings and outcomes, histologic patterns, and causes. Splenic samples of dogs diagnosed with splenitis between 2005 and 2013 were collected and stained with hematoxylin and eosin, Gram, green-Gram, Giemsa, periodic acid-Schiff, and Ziehl-Neelsen. Samples were processed for polymerase chain reaction (PCR) to detect bacteria, fungi, and protozoa (Leishmania infantum, Hepatozoon canis). Thirty-three of 660 splenic samples (5%) had splenitis. Clinical findings and outcomes were available in 19 dogs (58%); 49% had weakness, 33% had fever, and 84% survived. The most frequent inflammatory patterns included purulent splenitis (27%), pyogranulomatous splenitis (24%), and neutrophilic perisplenitis (15%). One dog had a putative diagnosis of primary splenitis; in 8 dogs, microorganisms were identified histologically or by PCR in the spleen without obvious comorbidities. Twenty-four dogs (73%) had concurrent diseases; a permissive role in the development of splenitis was suspected in 21 of these cases. Histologic examination identified the cause of splenitis in 10 dogs. Bacteria were identified by PCR in 23 cases, but the bacteria were confirmed histologically in only 6 of these. Leishmania was detected with PCR in 6 dogs. Leishmania was identified in 1 dog and H. canis in another histologically, but both were PCR negative. Fungi were identified in 8 spleens by PCR and in 1 by histology. This study suggests that splenitis is uncommon in dogs and is frequently associated with systemic diseases. Prognosis is favorable in most cases. Identification of bacteria, fungi, and protozoa in the spleens of affected dogs with PCR should be interpreted cautiously, because the findings are not confirmed histologically in many cases.

Published
2017

121. Crohn’s disease-associated small bowel carcinomas show distinctive histology and phenotype in comparison to sporadic cases: an italian multicentre study

Author

Vanoli, A., Grillo, F., Mescoli, C., Nesi, G., Giuffrida, P., Papi, C., Luinetti, O., Sampietro, G., Latella, Giovanni, Fociani, P., Tonelli, F., Cannizzaro, R., Coppola, L., D’Incà, R., Monteleone, G., Biancone, L., Solina, G., Villanacci, V., Martino, M., Orlandi, A., Rizzo, A., Salemme, M., Astegiano, M., Migliora, P., Rugge, M., Fiocca, R., Corazza, G. R., Solcia, E., and Di Sabatino, A.

Published
2016

122. Observations of open-ocean deep convection in the northwestern Mediterranean Sea: Seasonal and interannual variability of mixing and deep water masses for the 2007-2013 Period

Author

Houpert, L., Durrieu De Madron, X. Durrieu, Testor, P., Bosse, A., D'Ortenzio, F., Bouin, M. N., Dausse, D., Le Goff, H., Kunesch, S., Labaste, M., Coppola, L., Mortier, L., Raimbault, P., Scottish Association for Marine Science (SAMS), Centre de Formation et de Recherche sur les Environnements Méditérranéens (CEFREM), Université de Perpignan Via Domitia (UPVD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Variabilité de l'Océan et de la Glace de mer (VOG), Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques (LOCEAN), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre national de recherches météorologiques (CNRM), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Développement Instrumental et Techniques Marines (DITM), École Nationale Supérieure de Techniques Avancées (ENSTA Paris), Institut méditerranéen d'océanologie (MIO), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), ANR-10-EQPX-0040,NAOS,Observations de l'océan global pour l'étude et la prévision de l'océan et du climat: préparation de la nouvelle décennie d'Argo(2010), European Project: 226354,EC:FP7:ENV,FP7-ENV-2008-1,HERMIONE(2009), European Project: 287600,EC:FP7:ENV,FP7-OCEAN-2011,PERSEUS(2012), Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Groupe d'étude de l'atmosphère météorologique (CNRM-GAME), and Institut national des sciences de l'Univers (INSU - CNRS)-Météo France-Centre National de la Recherche Scientifique (CNRS)

Subjects
open-ocean deep convection, gulf of lions, dense water formation, Mediterranean Sea, ocean observations, mixed layer, physical oceanography, deep water, [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography
Abstract

International audience; We present here a unique oceanographic and meteorological data set focus on the deep convection processes. Our results are essentially based on in situ data (mooring, research vessel, glider, and profiling float) collected from a multiplatform and integrated monitoring system (MOOSE: Mediterranean Ocean Observing System on Environment), which monitored continuously the northwestern Mediterranean Sea since 2007, and in particular high-frequency potential temperature, salinity, and current measurements from the mooring LION located within the convection region. From 2009 to 2013, the mixed layer depth reaches the seabed, at a depth of 2330m, in February. Then, the violent vertical mixing of the whole water column lasts between 9 and 12 days setting up the characteristics of the newly formed deep water. Each deep convection winter formed a new warmer and saltier “vintage” of deep water. These sudden inputs of salt and heat in the deep ocean are responsible for trends in salinity (3.3 ± 0.2 × 10−3/yr) and potential temperature (3.2 ± 0.5 × 10−3 C/yr) observed from 2009 to 2013 for the 600–2300 m layer. For the first time, the overlapping of the three “phases” of deep convection can be observed, with secondary vertical mixing events (2–4 days) after the beginning of the restratification phase, and the restratification/spreading phase still active at the beginning of the following deep convection event.

Published
2016

123. Crohn’s disease-associated small bowel carcinomas show distinctive histologic and phenotypic features: an Italian multicentric study

Author

Di Sabatino, A. Vanoli, Grillo, Francesco, Mescoli, C., Nesi, G., Giuffrida, P., Papi, C., Luinetti, O., Sampietro, G., Latella, Giovanni, Fociani, P., Tonelli, F., Cannizzaro, R., Coppola, L., D’Incà, R., Monteleone, G., Biancone, L., Solina, G., Villanacci, V., Martino, M., Orlandi, A., Rizzo, A., Salemme, M., Astegiano, M., Migliora, P., Rugge, M., Fiocca, R., and Corazza, G. R.

Published
2016

124. Estimating dense water volume and its evolution for the year 2012-2013 in the Northwestern Mediterranean Sea: An observing system simulation experiment approach

Author

Waldman, R., Somot, S., Herrmann, Marine, Testor, P., Estournel, C., Sevault, F., Prieur, L., Mortier, L., Coppola, L., Taillandier, V., Conan, P., Dausse, D., Centre national de recherches météorologiques (CNRM), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Variabilité de l'Océan et de la Glace de mer (VOG), Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques (LOCEAN), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'aérologie (LAERO), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Développement Instrumental et Techniques Marines (DITM), Groupe d'étude de l'atmosphère météorologique (CNRM-GAME), Institut national des sciences de l'Univers (INSU - CNRS)-Météo France-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, and Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Mediterranean Sea, OSSE, [PHYS.PHYS.PHYS-GEO-PH]Physics [physics]/Physics [physics]/Geophysics [physics.geo-ph], ocean deep convection
Abstract

International audience; The Northwestern Mediterranean (NWMed) Sea includes one of the best observed ocean deep convection sites in the World. An observing system simulation experiment (OSSE) is developed to provide a methodology for estimating observing network errors. It is applied to quantify dense water volumes in the NWMed during 2012-2013 with their observation error from MOOSE network. Results from the OSSE show low spatiotemporal sampling errors, which confirms MOOSE network ability to measure dense waters. However, results are highly sensitive to instrumental stability. The dense water volume is then estimated in observations from four ship cruises between summers 2012 and 2013. A large seasonal cycle is found, maximal in spring 2013 and dominated by the area west of 6.58E. The dense water volume ( \sigma0 29.11 kg/m3) is stable between summer 2012 (13.3 +/- 0.6 x 1013 m3) and winter 2013 (13.7 +/- 1.3 x 1013 m3). It increases dramatically in spring 2013 (17.7 +/- 0.9 x 1013 m3) due to an intense convective event, and it finally decreases rapidly in summer 2013 (15.1 +/- 0.6 x 1013 m3) due to restratification and spreading. We estimate an open-sea dense water formation (DWF) rate of 1.4 +/- 0.3 Sv between summer 2012 and spring 2013 over the studied area, extrapolated to 2.3 +/- 0.5 Sv over the whole NWMed Sea and for the optimal timing. This is to our knowledge the highest measured DWF rate, suggesting winter 2013 was exceptionally convective. The observed restratification rate between spring and summer 2013 is -0.8 +/-0.4 Sv. This study provides robust quantifications of deep convection during an exceptional event that will allow to evaluate numerical simulations.

Published
2016

125. The methodology of the Italian HBSC 2010 study (Health Behaviour in School-aged Children)

Author

Lazzeri, G, Giacchi, M, Dalmasso, P, Vieno, A, Nardone, P, Lamberti, A, Spinelli, A, Cavallo, F, Lemma, P, Berchialla, P, Colombini, S, Zambon, A, Charrier, L, Borraccino, A, Pilato, V, Rossi, S, Pammolli, A, Santinello, M, Chieco, F, Lenzi, M, Baglio, G, Galeone, D, Spizzichino, L, Menzano, M, Scotti, M, Silani, M, Teti, S, Ciglia, A, Di Giacomo, M, Spinosa, S, Ammirati, G, Cauzillo, G, Sorrentino, G, Azzarito, C, La Rocca, M, Pizzuti, R, Mazzarella, G, Di Martino, E, Angelini, P, Fridel, M, Bavcar, A, Castronuovo, G, Pascali, F, Celata, C, Tosi, M, Velasco, V, Bonfanti, M, Coppola, L, Giostra, G, Ciallella, M, Caputo, M, Viesti, E, Rosa, G, Anelli, S, Meloni, S, Senis, M, Masala, R, Cernigliaro, A, Rizzo, S, Giannoni, A, Cristofori, M, Covarino, A, D'Alessandro, G, Piffer, S, Fanolla, A, Weiss, S, Lazzeri G., Giacchi M. V., Dalmasso P., Vieno A., Nardone P., Lamberti A., Spinelli A., Cavallo F., Lemma P., Berchialla P., Colombini S., Zambon A., Charrier L., Borraccino A., Pilato V., Rossi S., Pammolli A., Santinello M., Chieco F., Lenzi M., Baglio G., Galeone D., Spizzichino L., Menzano M. T., Scotti M. T., Silani M. T., Teti S., Ciglia A., Di Giacomo M., Spinosa S., Ammirati G., Cauzillo G., Sorrentino G., Azzarito C., La Rocca M., Pizzuti R., Mazzarella G., Di Martino E., Angelini P., Fridel M., Bavcar A., Castronuovo G. C. E., Pascali F., Celata C., Tosi M., Velasco V., Bonfanti M., Coppola L., Giostra G., Ciallella M. L., Caputo M., Viesti E., Rosa G., Anelli S., Meloni S., Senis M. L., Masala R., Cernigliaro A., Rizzo S., Giannoni A. M., Cristofori M., Covarino A. M., D'alessandro G., Piffer S., Fanolla A., Weiss S., Lazzeri, G, Giacchi, M, Dalmasso, P, Vieno, A, Nardone, P, Lamberti, A, Spinelli, A, Cavallo, F, Lemma, P, Berchialla, P, Colombini, S, Zambon, A, Charrier, L, Borraccino, A, Pilato, V, Rossi, S, Pammolli, A, Santinello, M, Chieco, F, Lenzi, M, Baglio, G, Galeone, D, Spizzichino, L, Menzano, M, Scotti, M, Silani, M, Teti, S, Ciglia, A, Di Giacomo, M, Spinosa, S, Ammirati, G, Cauzillo, G, Sorrentino, G, Azzarito, C, La Rocca, M, Pizzuti, R, Mazzarella, G, Di Martino, E, Angelini, P, Fridel, M, Bavcar, A, Castronuovo, G, Pascali, F, Celata, C, Tosi, M, Velasco, V, Bonfanti, M, Coppola, L, Giostra, G, Ciallella, M, Caputo, M, Viesti, E, Rosa, G, Anelli, S, Meloni, S, Senis, M, Masala, R, Cernigliaro, A, Rizzo, S, Giannoni, A, Cristofori, M, Covarino, A, D'Alessandro, G, Piffer, S, Fanolla, A, Weiss, S, Lazzeri G., Giacchi M. V., Dalmasso P., Vieno A., Nardone P., Lamberti A., Spinelli A., Cavallo F., Lemma P., Berchialla P., Colombini S., Zambon A., Charrier L., Borraccino A., Pilato V., Rossi S., Pammolli A., Santinello M., Chieco F., Lenzi M., Baglio G., Galeone D., Spizzichino L., Menzano M. T., Scotti M. T., Silani M. T., Teti S., Ciglia A., Di Giacomo M., Spinosa S., Ammirati G., Cauzillo G., Sorrentino G., Azzarito C., La Rocca M., Pizzuti R., Mazzarella G., Di Martino E., Angelini P., Fridel M., Bavcar A., Castronuovo G. C. E., Pascali F., Celata C., Tosi M., Velasco V., Bonfanti M., Coppola L., Giostra G., Ciallella M. L., Caputo M., Viesti E., Rosa G., Anelli S., Meloni S., Senis M. L., Masala R., Cernigliaro A., Rizzo S., Giannoni A. M., Cristofori M., Covarino A. M., D'alessandro G., Piffer S., Fanolla A., and Weiss S.

Abstract

Italy has participated in the Health Behaviour in School-aged Children (HBSC) study since 2000. These surveys collect data every four years on the well-being and health behaviour of boys and girls aged 11, 13 and 15. Until 2007, the coordination group of the University of Turin, Siena and Padua directly sent the questionnaires to each sampled school to collect the data. The sample of about 4500 students was nationally representative. In 2008 the HBSC became part of the project "Surveys on behavioral risks in children aged 6-17 years", coordinated by the National Institute of Health (ISS) and promoted by the Ministry of Health, in collaboration with the Ministry of Education, University and Research. For the first time, in 2010, the survey was conducted by health workers in collaboration with teachers in all regions with a representative sample, not just at the national level, but also at regional level. In the 2,504 sampled schools, 77,113 students (25,079 eleven-year-old, 26,048 thirteen-year-old and 25,986 fifteen-year-old) completed an anonymous questionnaire. Knowledge of the health-related behaviour of school-aged adolescents may help monitoring and enable policies for young people to be formulated and implemented.

Published
2013

127. OC.10.4: Survival of Non-Familial Small Bowel Carcinomas Depends on the Underlying Intestinal Immune-Mediated Disorder

Author

Di Sabatino, A., primary, Vanoli, A., additional, Furlan, D., additional, Giuffrida, P., additional, Klersy, C., additional, Grillo, F., additional, Fiocca, R., additional, Mescoli, C., additional, Rugge, M., additional, Nesi, G., additional, Fociani, P., additional, Sampietro, G.M., additional, Ardizzone, S., additional, Luinetti, O., additional, Calabrò, A., additional, Tonelli, F., additional, Volta, U., additional, Santini, D., additional, Elli, L., additional, Ferrero, S., additional, Latella, G., additional, Ciardi, A., additional, Solina, G., additional, Rizzo, A., additional, Ciacci, C., additional, D’Armiento, F.P., additional, Villanacci, V., additional, Cannizzaro, R., additional, Canzonieri, V., additional, Reggiani Bonetti, L., additional, Biancone, L., additional, Monteleone, G., additional, Orlandi, A., additional, Santeusanio, G., additional, Macciomei, M.C., additional, D’Incà, R., additional, Perfetti, V., additional, Sandri, G., additional, Silano, M., additional, Giannone, A.G., additional, Papi, C., additional, Coppola, L., additional, Usai, P., additional, Maccioni, A., additional, Astegiano, M., additional, Migliora, P., additional, Manca, R., additional, Martino, M., additional, Trapani, D., additional, Cerutti, R., additional, Alberizzi, P., additional, Riboni, R., additional, Sessa, F., additional, Paulli, M., additional, Solcia, E., additional, and Corazza, G.R., additional

Published
2017
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131. Screening for colorectal cancer in Italy: 2011-2012 survey

Author

Zorzi, Manuel, Da Re, Filippo, Mantellini, Paola, Naldoni, Carlo, De Bianchi, Priscilla Sassoli, Senore, Carlo, Turrin, Anna, Visioli, Carmen Beatriz, Zappa, Marco, Crotta, S., Senore, C., Polizzi, S., Sartori, M., Alibrandi, M. P., Germinetti, F., Bestagini, P., Orione, L., Miroglio, T., Faragli, G., Cereda, D., Coppola, L., Zerbi, L., Gramegna, M., Tessandri, L., Imbrogno, P., Rocca, G., Pesenti, B., Schivardi, M., Crisetig, M., Grassi, E., Speziani, F., Gola, G., Gotti, S., Dal Soldà, M., Boldori, L., Moretti, G., Ilardo, A., Ieni, A, Belloni, A., Rossetti, E., Marazza, G., Anghinoni, E., Silvestri, A., Tidone, E., Frammartino, B., Leonardo, N., Deandrea, S., Ceresa, P., Beghi, G., Lucchini, R., Acerbi, L., Lo Buono, F., Cavalieri D'Oro, L., Magenes, G., Camana, L., Cioccarelli, A. M., Fanetti, A. C., Cecconami, L., Bardelli, R., Violini, M., Sambo, F., Domenighini, S., Pieracci, G., Pertile, R., Piffer, S., Fedato, C., Franzo, A., Fabro, J., Gobbato, M., Zanier, L., Bonelli, L., Orlando, M., Vaccari, D., Franxo, A., Scotto, M., Valle, I., Ferrari Bravo, M., Sticchi, C., Maddalo, F., Pensa, F., Naldoni, C., Sassoli De Bianchi, P., Landi, P., Borciani, E., Fornari, F., Gatti, G., Zurlini, C., Zatelli, M., Maradini, F., Paterlini, L., Campari, C., Sassatelli, R., Corradini, R., Goldoni, C., Pasquini, A., Manfredi, M., Baldazzi, P., Nannini, R., Caprara, L., Carpanelli, M. C., Zoli, G., Matarese, V., Triossi, O., Serafini, M., Vitali, B., Falcini, F., Colamartini, A., Giuliani, O., Vattiato, R., Palazzi, M., Imolesi, C., Pazzi, P., Canuti, D., Casale, C., Giovanardi, M., Monticelli, G., Nicolai, C., Vivani, P., Giorgi, D., Finucci, G., Rapanà, M., Epifani, C., Abdelghani, L., Allegrini, G., Maffei, C., Turillazzi, R., Mirri, F., Ceccatelli, P., Rosati, R., Piacentini, P., Visioli, C. B., Falini, P., Amico, P., Ciabattoni, C., Giaimo, M., Prandini, S., Vinti, G., Di Marco, A., Malaspina, M., Corvetti, R., Di Furia, L., Barca, A., Baiocchi, D., Quadrino, F., Di Giacomo, M., Lattanzio, F. M., Minna, M., Di Credico, A., Pizzuti, R., Sigillito, A., Montesi, M. P., Landro, T., Giorno, A., Santino, M., Magrì, G., Ferrara, G., and Masala, R.

Subjects
Flexible sigmoidoscopy, National survey, Faecal immunochemical test, Italy, Colorectal cancer, Screening, Epidemiology, Public Health, Environmental and Occupational Health, Environmental and Occupational Health, Public Health
Published
2015

132. Physical activity as a key issue for promoting human health on a local and global scale: evidences and perspectives.

Author

Scatigna, M., D'Eugenio, S., Cesarini, V., Coppola, L., Lemma, P., Fabiani, L., and Spica, V. Romano

Subjects
PHYSICAL activity, POPULATION health, SOCIOECONOMICS, SUSTAINABLE development
Abstract

Copyright of Annali di Igiene, Medicina Preventiva e di Comunità is the property of Societa Editrice Universo s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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133. Analysis of water self-diffusion in polycrystalline lamellar systems by pulsed field gradient nuclear magnetic resonance experiments.

Author

Coppola, L., La Mesa, C., Ranieri, G. A., and Terenzi, M.

Subjects
*WATER, *DIFFUSION, *NUCLEAR magnetic resonance
Abstract

A study of the water self-diffusion in polycrystalline lamellar systems, by pulsed field gradient spin-echo (PFG-SE) nuclear magnetic resonance (NMR) experiments, is reported here. Our analysis confirmed the validity of previous equations for bidimensional water self-diffusion in lamellar lyomesophases and clarified their applicability limits. Depending on the diffusion experimental time range, two different procedures can be built up; for wide amplitude windows, the experimental diffusion coefficients are correlated to the fraction of bound water, whereas for short times it has been possible to point out the ‘‘obstruction factor’’ to diffusion. Experimental support for the theoretical findings was inferred by investigation of the lamellar mesophase of the binary system water/sodium-bis-2-ethylhexyl sulfosuccinate (AOT). It confirmed the existence of some defects in the lamellae at water concentration higher than 70 wt. %. [ABSTRACT FROM AUTHOR]

Published
1993
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134. Antioxidant Profile and in Vitro Cardiac Radical-Scavenging versus Pro-oxidant Effects of Commercial Red Grape Juices ( Vitis vinifera L. cv. Aglianico N.)

Author

Tenore GC, Manfra M, Coppola L, Russo M, Gomez Monterrey IM, Campiglia P., STIUSO, Paola, Tenore, Gc, Manfra, M, Stiuso, Paola, Coppola, L, Russo, M, Gomez Monterrey, Im, and Campiglia, P.

Abstract

Several works have reported on the pharmaceutical usefulness of grape phytochemicals. Nevertheless, the scientific literature needs further studies to consider grape extracts as useful dietary supplements. The aim of the present work was to hypothesize for the first time the use of whole commercial red grape juices as food supplements potentially useful against both physiological and induced cardiac oxidative stress. First of all, the results indicated a good antioxidant stability of the juice sample to lyophilization that may be reasonably regarded as a suitable process for the formulation of food supplements. Then, the processed sample (lioRGJ) was tested on cardiac-derived H9C2 myocytes to ascertain its effects on reactive oxygen species (ROS) generation and caspase-3 activity incubating cardiomyocytes with lioRGJ at increasing doses (0.01-1 μg). Experiments showed an appreciable direct radical-scavenging activity at a maximum sample dose of 0.01 μg that made the caspase-3 activity decrease by about 47% (P < 0.001). Cardiac cells were exposed to 1 μM doxorubicin and its combination with different doses of lioRGJ. A maximum sample aliquot of 0.01 μg seemed to effectively contrast the induced oxidant injury, decreasing the ROS levels by about 31% and depressing the caspase-3 activity by about 60% (P < 0.001). In both assays, pro-oxidant effects at higher sample concentrations were detected as indicated by the increase in both ROS generation and apoptotic activity. The data suggested the possible employment of the juice sample as a food supplement with prospective cardioprotective benefits, although further studies are needed to optimize its dosages to avoid harmful pro-oxidant effects.

Published
2012

135. Effects of six days a week low protein dietary intervention on depressive symptoms in elderly diabetic subjects

Author

Ciarambino T., Ferrara N., Castellino P., Paolisso G., Coppola L., Giordano M., Ciarambino, T., Ferrara, N., Castellino, P., Paolisso, G., Coppola, L., and Giordano, M.

Subjects
Low protein diet, Elderly, Depression
Abstract

Objectives. Late-life depression is one of the main health issues among elderly diabetic subjects. In addition, depression is common among renal failure patients and most of these follow a low protein diet regimen (LPD). However, the effects of LPD on depressive symptoms are unclear. Methods. In the present study, the effects of LPD regimen on depressive symptoms in 40 elderly type 2 diabetic subjects with renal failure were investigated. All participants with a normal protein diet regimen providing 1.2 g/kg per d were instructed to consume either a LPD providing 0.8 g/kg per d, 7 d a wk (LPD 7/7), or a LPD providing 0.8 g/kg per 6 d a wk (LPD 6/7) randomly. Results. Mean scores of 15-item Geriatric Depression Scale (GDS-15) (1.9 ± 0.5) and of Beck Depression Inventory (BDI) (3.8±0.9), during normal protein diet regimen, significantly increased to 6.4 ± 1.5 and 11.6 ± 1.3, respectively, after LPD 7/7 (P < 0.05 versus normal protein diet). However, after LPD 6/7, mean GDS-15 and BDI significantly decreased to 3.6 ± 0.6 and 6.4 ± 1.6, respectively (p < 0.05 vs. LPD 7/7). Conclusions. LPD 6/7 regimen significantly decreased depressive symptoms in young-old type 2 diabetic patients.

Published
2012

136. Effects of In Vivo C1 Inhibitor Infusion on Activated Factor XII and Prothrombin Fragment F1.2 in Hereditary Angioedema Patients

Author

GUASTAFIERRO, Salvatore, Falcone U, Ferrara MG, Sica A, Parascandola RR, Coppola L. 1, Maria Giovanna Ferrara 1, Antonello Sica 1, Rita Rosaria Parascandola 1, Ludovico Coppola 2, Guastafierro, Salvatore, Falcone, U, Ferrara, Mg, Sica, A, Parascandola, Rr, Coppola, L. 1., Maria Giovanna Ferrara, 1, Antonello Sica, 1, Rita Rosaria Parascandola, 1, and Ludovico Coppola, 2

Published
2012

139. Gastric GISTs: Analysis of c-Kit, PDGFRA and BRAF mutations in relation to prognosis and clinical pathological characteristics of patients – A GIRCG study

Author

Capelli, L., Petracci, E., Quagliuolo, V., Saragoni, L., Colombo, P., Morgagni, P., Calistri, D., Tomezzoli, A., Di Cosmo, M., Roviello, F., Vindigni, C., Coniglio, A., Villanacci, V., Catarci, M., Coppola, L., Alfieri, Sergio, Ricci, Riccardo, Capella, C., Rausei, Stefano, Gulino, D., Amadori, D., Ulivi, P., Alfieri, Sergio (ORCID:0000-0002-0404-724X), Ricci, Riccardo (ORCID:0000-0002-9089-5084), Capelli, L., Petracci, E., Quagliuolo, V., Saragoni, L., Colombo, P., Morgagni, P., Calistri, D., Tomezzoli, A., Di Cosmo, M., Roviello, F., Vindigni, C., Coniglio, A., Villanacci, V., Catarci, M., Coppola, L., Alfieri, Sergio, Ricci, Riccardo, Capella, C., Rausei, Stefano, Gulino, D., Amadori, D., Ulivi, P., Alfieri, Sergio (ORCID:0000-0002-0404-724X), and Ricci, Riccardo (ORCID:0000-0002-9089-5084)

Abstract

Background Gastric gastrointestinal stromal tumors (GISTs) represent a subgroup of GISTs with a better prognosis than those located in other areas. In this retrospective study we performed a molecular characterization of a large series of patients with gastric GISTs in relation to clinical–pathological characteristics and prognosis. Methods DNA was extracted from paraffin-embedded sections from 221 gastric GIST patients submitted to surgery. Exons 9, 11, 13 and 17 of KIT, exons 12 and 18 of PDGFRA and exons 11 and 15 of BRAF were analyzed by direct sequencing. Cox regression analysis adjusted for clinical–pathological factors was performed to evaluate KIT and PDGFRA mutations in relation to the composite endpoint of relapse or death. Results KIT and PDGFRA mutations were observed in 119 (53.8%) and 56 (25.3%) patients, respectively, whereas 46 (20.8%) patients had wild type (wt) disease. Univariable analyses showed that a high Miettinen risk category and the presence of ulceration and KIT deletions were associated with increased risk of relapse or death (p < 0.001; p = 0.0389 and p = 0.002, respectively). After adjusting for Miettinen risk score, KIT deletions remained an independent prognostic factor (HRadj = 2.65, 95% CI [1.15–6.13], p = 0.023). Moreover, KIT deletions in exon 11 codons 557, 558 or 559 were associated with a higher risk of relapse or death than wt tumors (HRadj = 3.29 95% CI [1.64–6.64], p = 0.001). Conclusions KIT deletions in exon 11, especially those involving codons 557, 558 or 559, were correlated with a more aggressive gastric GIST phenotype and increased risk of relapse or death.

Published
2016

141. ITP-like syndrome in cancer patients

Author

GUASTAFIERRO, Salvatore, Ferrara MG, Sica A, Falcone U, Rotunno R, Santangelo S, Coppola L, LUCIVERO, Giacomo, Guastafierro, Salvatore, Ferrara, Mg, Sica, A, Falcone, U, Rotunno, R, Santangelo, S, Coppola, L, and Lucivero, Giacomo

Published
2010

145. Blood donation and plasmatic fibrinogen levels

Author

GUASTAFIERRO, Salvatore, Sessa F, Falcone U, Ferrara MG, Sica A, Cuomo C, Mastrolorenzo L, Coppola L., Guastafierro, Salvatore, Sessa, F, Falcone, U, Ferrara, Mg, Sica, A, Cuomo, C, Mastrolorenzo, L, and Coppola, L.

Published
2010

147. HyMeX-SOP1, the field campaign 1 dedicated to 2 heavy precipitation and flash flooding in 3 the northwestern Mediterranean

Author

Ducrocq, V, Braud, I., Davolio, S., Ferretti, Rossella, Flamant, C., Jansa, A., Kalthoff, N., Richard, E., Taupier Letage, I., Ayral, P. A., Belamari, S., Berne, A., Borga, M., Boudevillain, B., Bock, O., Boichard, J. L., Bouin, M. N., Bousquet, O., Bouvier, C., Chiggiato, J., Cimini, D., Corsmeier, U., Coppola, L., Cocquerez, P., Defer, E., Delanoë, J., Di Girolamo, P., Doerenbecher, A., Drobinski, P., Dufournet, Y., Fourrié, N., Gourley, J. J., Labatut, L., Lambert, D., Le Coz, J., Marzano, F. S., Molinié, G., Montani, A., Nord, G., Nuret, M., Ramage, K., Rison, B., Roussot, O., Said, F., Schwarzenboeck, A., Testor, P., Van Baelen, J., Vincendon, B., Aran, M., and Tamayo, J.

Subjects
heavy precipitation, natural hazards, field experiment
Published
2014

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