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106. In Vivo Near-Infrared Fluorescence Imaging of Aqueous Humor Outflow Structures.

Author

Zeppa, L., Ambrosone, L., Guerra, G., Fortunato, M., and Costagliola, C.

Abstract

The aim of this study has been to visualize the aqueous outflow system in patients affected by primary open angle glaucoma. A solution of indocyanine green (ICG) plus high viscosity viscoelastic solution was injected into the Schlemm canal during surgery in 10 glaucomatous patients undergoing canaloplasty. Soon after injection of the dye the borders of the scleral flap were completely stained due to partial reflux caused by the intrachannel resistance; progression of the dye along the Schlemm canal starting from the site of injection was then visualized. The filling of the collector channels was observed only in the patent portions of the Schlemm canal. The only noticeable aqueous veins were located in correspondence of the quadrant in which both the Schlemm canal and the collectors were patent. Lastly, a retrograde filling, of glomerular-shaped structures, deepest to the Schlemm canal was observed in the quadrants where the pathway was functioning. Our findings show that injection of a mixture composed of ICG and viscoelastic solution into the Schlemm canal allows a clear visualization of the functioning portions of the conventional outflow pathway. In addition, a retrograde filling of structures presumably located into the iris was also recorded. Clinical Trial Registration. Our study is registered in ISRCTN registry, number 54005880, DOI 10.1186/ISRCTN54005880. [ABSTRACT FROM AUTHOR]

Published
2016
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112. CLOSE RELATIONSHIP BETWEEN MEDIA TO LUMEN RATIO OF SUBCUTANEOUS SMALL ARTERIES AND WALL TO LUMEN RATIO OF RETINAL ARTERIOLES EVALUATED NON INVASIVELY BY SCANNING LASER DOPPLER FLOWMETRY

Author

Rizzoni, D., primary, De Ciuceis, C., additional, Porteri, E., additional, La Boria, E., additional, Duse, S., additional, Semeraro, F., additional, Costagliola, C., additional, Sebastiani, A., additional, Danzi, P., additional, Tiberio, G. A. M., additional, Giulini, S. M., additional, Agabiti Rosei, C., additional, Sarkar, A., additional, Avanzi, D., additional, and Agabiti Rosei, E., additional

Published
2011
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117. Cataract risk factors: blood level of antioxidative vitamins, reduced glutathione and malondialdehyde in cataractous patients

Author

Libondi, T., Costagliola, C., Della Corte, M., Francesco Facchiano, Menzione, M., Savastano, S., Simonelli, F., Rinaldi, E., Auricchio, G., Libondi, T, Costagliola, Ciro, DELLA CORTE, M, Facchiano, F, Menzione, M, Savastano, S, Simonelli, F, Rinaldi, E, and Auricchio, G.

Subjects
Male, Erythrocytes, Ascorbic Acid, Middle Aged, Glutathione, Antioxidants, Cataract, Age Distribution, Risk Factors, Malondialdehyde, Humans, Vitamin E, Female, Sex Distribution, Aged
Abstract

Since many years experimental evidences have suggested an association between nutrition and lens opacities. A dietary deficiency of antioxidants and reactive oxygen scavengers may be involved in the pathogenesis of the "idiopathic" human senile cataract, as it has been demonstrated in some experimental cataracts. We tested the levels of ascorbic acid (vit. C), alpha-tocopherol (vit. E), reduced glutathione (GSH) and malondialdehyde (MDA) in the plasma or in the red blood cells (RBC) of 42 patients who were affected by surgically significant cataract and of 40 age-matched controls. Plasma vit. C mean level was 4.46 gamma/ml in cataracts and 4.62 gamma/ml in controls, while vit. E level was 7.70 and 7.09 gamma/ml respectively. RBC GSH was found to be 342 gamma/ml in cataracts and 346 in controls, while the MDA content was 4.06 picoMol/ml and 4.08 picoMol/ml respectively. The level of each tested nutrient or metabolite was not found to be statistically different between cataractous patients and controls, nor any significant trend was found to be present when the nutrients and metabolites were correlated to each other. Our results do not support the hypothesis of a nutritional deficiency in human senile cataracts. However, a defect in the antioxidative metabolism pathways could be present either systemically or at lens level.

Published
1991

125. Neurotrophic Keratitis.

Author

Semeraro, F., Forbice, E., Romano, V., angi, M., Romano, M.R., Filippelli, M.E., Di Iorio, R., and Costagliola, C.

Subjects
KERATITIS, ANESTHESIA, CORNEAL sensitivity, EPITHELIAL cells, MITOSIS
Abstract

Neurotrophic keratitis (NK) is a rare degenerative corneal disease that occurs as a result of partial or total impairment of trigeminal innervations, leading to a reduction (hypoesthesia) in or loss (anaesthesia) of corneal sensitivity. The impairment of sensory innervation causes a reduction in the lacrimation reflex and the vitality, metabolism and mitosis of epithelial cells, with subsequent deficiency in epithelial repair, stromal and intracellular oedema, loss of microvilli, and abnormal development of the basal lamina. Several recent studies have proposed different therapies based on different aetiopathogenetic theories. The aim of the therapy is to treat aetiopathogenesis and, at the same time, promote corneal healing. In this paper, we report the aetiology, diagnosis, management, and medical and surgical treatment of NK, also indicating future treatments based on the most recent studies. © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2014
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126. Work- and non-work-related eye injuries in a highly industrialized area in northern Italy: comparison between two three-year periods (1994-1996 and 2005-2007).

Author

SEMERARO, F., POLCINI, C., FORBICE, ELIANA, MONFARDINI, A., COSTAGLIOLA, C., and APOSTOLI, P.

Subjects
WORK-related injuries, OCULAR injuries, COMPARATIVE studies, EPIDEMIOLOGY, DEVELOPED countries
Abstract

Copyright of La Medicina del Lavoro is the property of Mattioli 1885 SpA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2013

145. Quantitative evaluation of the retinal venous tortuosity in chronic anaemic patients affected by B-thalassaemia major.

Author

Incorvaia, C, Parmeggiani, F, Costagliola, C, Perri, P, D'Angelo, S, and Sebastiani, A

Subjects
ANEMIA, DEFEROXAMINE, FERRITIN, QUANTITATIVE chemical analysis
Abstract

Aims Retinal venous tortuosity (RVT) is a common finding in patients affected by different forms of chronic anaemia. The aims of this study were to quantify RVT in anaemic patients with ß-thalassaemia major and to verify whether it is related to some of the following parameters: patient's age, ferritin plasma level, and Desferrioxamine (DFX) daily dosage. Methods A retrospective study was carried out. In total, 36 consecutive thalassaemic patients, treated with polytransfusion regimen and DFX, were age- and sex-matched with a control group of 36 normal subjects. All subjects bilaterally underwent red-free fundus photography, centred on the optic disc. The four main retinal veins were measured with a computer-assisted method. Results Mean venous length in the thalassaemic group was significantly greater than that observed in the control group (Po0.001). In thalassaemic patients, no significant correlations between retinal venous length and, respectively, plasma ferritin level and DFX daily dosage were documented. Statistical analysis demonstrated a very significant association between patient's age and increased RVT only in thalassaemic patients (Po0.001). Conclusions Our findings demonstrate that patients with β-thalassaemia major have increased RVT, as compared to normal subjects. In this selected anaemic population, patient's age, closely related to anaemia duration, is the only variable responsible for the RVT increment. This clinical sign indicates a long-standing duration of anaemia. [ABSTRACT FROM AUTHOR]

Published
2003
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147. Losartan Potassium Oral Administration Decreased Intraocular Pressure in Humans: A Pilot Study.

Author

Costagliola, C., Verolino, M., Iaccarino, G., derosa, M.L., Ciancaglini, M., and Mastropasqua, L.

Subjects
*INTRAOCULAR pressure, *ANGIOTENSIN-receptor blockers, *ESSENTIAL hypertension
Abstract

Examines the effects of losartan potassium on intraocular pressure in control subjects and in patients with essential arterial hypertension. Adverse effects; Mechanisms of action; Systolic and diastolic arterial pressure variations.

Published
1999
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