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492 results on '"Cuccurullo, Franco"'

102. Overexpression of Functionally Coupled Cyclooxygenase-2 and Prostaglandin E Synthase in Symptomatic Atherosclerotic Plaques as a Basis of Prostaglandin E 2 -Dependent Plaque Instability

Author

Cipollone, Francesco, primary, Prontera, Cesaria, additional, Pini, Barbara, additional, Marini, Matteo, additional, Fazia, Maria, additional, De Cesare, Domenico, additional, Iezzi, Annalisa, additional, Ucchino, Sante, additional, Boccoli, Gianfranco, additional, Saba, Vittorio, additional, Chiarelli, Francesco, additional, Cuccurullo, Franco, additional, and Mezzetti, Andrea, additional

Published
2001
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106. Elevated Circulating Levels of Monocyte Chemoattractant Protein-1 in Patients With Restenosis After Coronary Angioplasty

Author

Cipollone, Francesco, primary, Marini, Matteo, additional, Fazia, Maria, additional, Pini, Barbara, additional, Iezzi, Annalisa, additional, Reale, Marcella, additional, Paloscia, Leonardo, additional, Materazzo, Guido, additional, D’Annunzio, Erminio, additional, Conti, Pio, additional, Chiarelli, Francesco, additional, Cuccurullo, Franco, additional, and Mezzetti, Andrea, additional

Published
2001
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111. Assessment of EGFR Mutations in Circulating Tumor Cell Preparations from NSCLC Patients by Next Generation Sequencing: Toward a Real-Time Liquid Biopsy for Treatment.

Author

Marchetti, Antonio, Del Grammastro, Maela, Felicioni, Lara, Malatesta, Sara, Filice, Giampaolo, Centi, Irene, De Pas, Tommaso, Santoro, Armando, Chella, Antonio, Brandes, Alba Ariela, Venturino, Paola, Cuccurullo, Franco, Crinò, Lucio, and Buttitta, Fiamma

Subjects
EPIDERMAL growth factor receptors, GENETIC mutation, CANCER cells, NUCLEOTIDE sequencing, BIOPSY, LUNG cancer, PHARMACOLOGY
Abstract

Introduction: Assessment of EGFR mutation in non-small cell lung cancer (NSCLC) patients is mandatory for optimization of pharmacologic treatment. In this respect, mutation analysis of circulating tumor cells (CTCs) may be desirable since they may provide real-time information on patient's disease status. Experimental Design: Blood samples were collected from 37 patients enrolled in the TRIGGER study, a prospective phase II multi-center trial of erlotinib treatment in advanced NSCLC patients with activating EGFR mutations in tumor tissue. 10 CTC preparations from breast cancer patients without EGFR mutations in their primary tumors and 12 blood samples from healthy subjects were analyzed as negative controls. CTC preparations, obtained by the Veridex CellSearch System, were subjected to ultra-deep next generation sequencing (NGS) on the Roche 454 GS junior platform. Results: CTCs fulfilling all Veridex criteria were present in 41% of the patients examined, ranging in number between 1 and 29. In addition to validated CTCs, potential neoplastic elements were seen in 33 cases. These included cells not fulfilling all Veridex criteria (also known as “suspicious objects”) found in 5 (13%) of 37 cases, and isolated or clustered large naked nuclei with irregular shape observed in 33 (89%) cases. EGFR mutations were identified by NGS in CTC preparations of 31 (84%) patients, corresponding to those present in matching tumor tissue. Twenty-five (96%) of 26 deletions at exon 19 and 6 (55%) of 11 mutations at exon 21 were detectable (P = 0.005). In 4 (13%) cases, multiple EGFR mutations, suggesting CTC heterogeneity, were documented. No mutations were found in control samples. Conclusions: We report for the first time that the CellSearch System coupled with NGS is a very sensitive and specific diagnostic tool for EGFR mutation analysis in CTC preparations with potential clinical impact. [ABSTRACT FROM AUTHOR]

Published
2014
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112. Morning Blood Pressure Surge, Dipping, and Risk of Ischemic Stroke in Elderly Patients Treated for Hypertension.

Author

Pierdomenico, Sante D., Pierdomenico, Anna M., and Cuccurullo, Franco

Subjects
BLOOD pressure, ISCHEMIA, STROKE, PATIENTS, HYPERTENSION, OLDER patients
Abstract

BACKGROUND The independent prognostic significance of morning surge (MS) in blood pressure (BP) is not yet clear. We investigated the association between MS in systolic BP (SBP) and risk of ischemic stroke in elderly patients treated for hypertension. METHODS Occurrence of ischemic stroke was evaluated in 1,191 elderly patients treated for hypertension (aged 60–90 years). Patients were divided according to tertiles of MS in SBP in the population as a whole, dipping status, and group-specific tertiles of MS in SBP in dippers and nondippers. RESULTS During follow-up (9.1±4.9 years, range 0.4–20 years), 139 ischemic strokes occurred. The event rate per 100 patient-years was 1.28. After adjustment for various covariates, Cox regression analysis showed that stroke risk was not significantly associated with tertiles of MS in SBP in the population as a whole. When nondippers and dippers were analyzed separately by group-specific tertiles of MS in SBP, stroke risk was not associated with MS in nondippers. Conversely, in dippers, stroke risk was significantly higher in the third tertile (>23mm Hg) of MS in SBP (hazard ratio, 2.08; 95% confidence interval, 1.03–4.23; P = 0.04). Additional analysis showed that stroke risk was significantly and similarly higher in dippers with MS >23mm Hg and in nondippers than in dippers with MS <23mm Hg. CONCLUSIONS In elderly patients treated for hypertension, high MS in SBP predicts stroke in dippers but not in nondippers. Nondippers are at high stroke risk with or without MS >23mm Hg. [ABSTRACT FROM PUBLISHER]

Published
2014
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113. Heightened free radical activity in angina pectoris

Author

Lapenna, Domenico, de Gioia, Sergio, Mezzetti, Andrea, Consoli, Agostino, Marzio, Leonardo, and Cuccurullo, Franco

Subjects
Free radicals (Chemistry) -- Physiological aspects, Angina pectoris -- Physiological aspects, Health
Published
1993

114. Increased Systemic Oxidative Stress After Elective Endarterectomy

Author

Mezzetti, Andrea, primary, Guglielmi, Maria D., additional, Pierdomenico, Sante D., additional, Costantini, Fabrizio, additional, Cipollone, Francesco, additional, De Cesare, Domenico, additional, Bucciarelli, Tonino, additional, Ucchino, Sante, additional, Chiarelli, Francesco, additional, Cuccurullo, Franco, additional, and Romano, Ferdinando, additional

Published
1999
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119. Copper/zinc ratio and systemic oxidant load: effect of aging and aging-related degenerative diseases

Author

Mezzetti, Andrea, primary, Pierdomenico, Sante D, additional, Costantini, Fabrizio, additional, Romano, Ferdinando, additional, De Cesare, Domenico, additional, Cuccurullo, Franco, additional, Imbastaro, Tiziana, additional, Riario-Sforza, Giuseppe, additional, Di Giacomo, Franco, additional, Zuliani, Giovanni, additional, and Fellin, Renato, additional

Published
1998
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123. Effect of Thyroid Function on LDL Oxidation

Author

Costantini, Fabrizio, primary, Pierdomenico, Sante D., additional, Cesare, Domenico De, additional, De Remigis, Pierluigi, additional, Bucciarelli, Tonino, additional, Bittolo-Bon, Gabriele, additional, Cazzolato, Giuseppe, additional, Nubile, Giuseppe, additional, Guagnano, Maria T., additional, Sensi, Sergio, additional, Cuccurullo, Franco, additional, and Mezzetti, Andrea, additional

Published
1998
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124. Increased Levels of Soluble P-Selectin in Hypercholesterolemic Patients

Author

Davı̀, Giovanni, primary, Romano, Mario, additional, Mezzetti, Andrea, additional, Procopio, Antonio, additional, Iacobelli, Stefano, additional, Antidormi, Teresa, additional, Bucciarelli, Tonino, additional, Alessandrini, Paola, additional, Cuccurullo, Franco, additional, and Bon, Gabriele Bittolo, additional

Published
1998
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127. Differential Suppression of Thromboxane Biosynthesis by Indobufen and Aspirin in Patients With Unstable Angina

Author

Cipollone, Francesco, primary, Patrignani, Paola, additional, Greco, Anita, additional, Panara, Maria Rosaria, additional, Padovano, Roberto, additional, Cuccurullo, Franco, additional, Patrono, Carlo, additional, Rebuzzi, Antonio G., additional, Liuzzo, Giovanna, additional, Quaranta, Gaetano, additional, and Maseri, Attilio, additional

Published
1997
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128. Reply

Author

Lapenna, Domenico, primary and cuccurullo, Franco, additional

Published
1997
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140. Effects of the novel anti-inflammatory compounds, N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulphonamide (NS-398) and 5-methanesulphonamido-6-(2, 4-difluorothiophenyl)-1-indanone (L-745, 337), on the cyclo-oxygenase activity of human blood prostaglandin

Author

Panara, Maria R., primary, Greco, Anita, additional, Santini, Giovanna, additional, Sciulli, Maria G., additional, Rotondo, Maria T., additional, Padovano, Roberto, additional, Giamberardino, Maria, additional, Cipollone, Francesco, additional, Cuccurullo, Franco, additional, Patrono, Carlo, additional, and Patrignani, Paola, additional

Published
1995
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142. The prooxidant properties of captopril

Author

Lapenna, Domenico, primary, De Gioia, Sergio, additional, Mezzetti, Andrea, additional, Ciofani, Giuliano, additional, Di Ilio, Carmine, additional, and Cuccurullo, Franco, additional

Published
1995
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145. Impaired Left Ventricular Diastolic Function and Vascular Postischemic Vasodilation Associated with Microalbuminuria in IDDM Patients

Author

Guglielmi, Maria D, primary, Pierdomenico, Sante D, additional, Salvatore, Luigi, additional, Romano, Ferdinando, additional, Tascione, Evandro, additional, Pupillo, Mario, additional, Porreca, Ettore, additional, Imbastaro, Tiziana, additional, Cuccurullo, Franco, additional, and Mezzetti, Andrea, additional

Published
1995
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