1,151 results on '"Czepiel, A."'
Search Results
102. Mortality Following Clostridioides difficile Infection in Europe: A Retrospective Multicenter Case-Control Study
- Author
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Jacek Czepiel, Marcela Krutova, Assaf Mizrahi, Nagham Khanafer, David A. Enoch, Márta Patyi, Aleksander Deptuła, Antonella Agodi, Xavier Nuvials, Hanna Pituch, Małgorzata Wójcik-Bugajska, Iwona Filipczak-Bryniarska, Bartosz Brzozowski, Marcin Krzanowski, Katarzyna Konturek, Marcin Fedewicz, Mateusz Michalak, Lorra Monpierre, Philippe Vanhems, Theodore Gouliouris, Artur Jurczyszyn, Sarah Goldman-Mazur, Dorota Wultańska, Ed J. Kuijper, Jan Skupień, Grażyna Biesiada, and Aleksander Garlicki
- Subjects
Clostridioides difficile infection ,co–morbidities ,mortality ,malignancy ,outcome ,risk factors ,Therapeutics. Pharmacology ,RM1-950 - Abstract
We aimed to describe the clinical presentation, treatment, outcome and report on factors associated with mortality over a 90-day period in Clostridioides difficile infection (CDI). Descriptive, univariate, and multivariate regression analyses were performed on data collected in a retrospective case-control study conducted in nine hospitals from seven European countries. A total of 624 patients were included, of which 415 were deceased (cases) and 209 were still alive 90 days after a CDI diagnosis (controls). The most common antibiotics used previously in both groups were β-lactams; previous exposure to fluoroquinolones was significantly (p = 0.0004) greater in deceased patients. Multivariate logistic regression showed that the factors independently related with death during CDI were older age, inadequate CDI therapy, cachexia, malignancy, Charlson Index, long-term care, elevated white blood cell count (WBC), C-reactive protein (CRP), bacteraemia, complications, and cognitive impairment. In addition, older age, higher levels of WBC, neutrophil, CRP or creatinine, the presence of malignancy, cognitive impairment, and complications were strongly correlated with shortening the time from CDI diagnosis to death. CDI prevention should be primarily focused on hospitalised elderly people receiving antibiotics. WBC, neutrophil count, CRP, creatinine, albumin and lactate levels should be tested in every hospitalised patient treated for CDI to assess the risk of a fatal outcome.
- Published
- 2021
- Full Text
- View/download PDF
103. Similar survival outcomes in patients with biclonal versus monoclonal myeloma: a multi-institutional matched case-control study
- Author
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Jurczyszyn, Artur, Gozzetti, Alessandro, Gdula-Argasińska, Joanna, Czepiel, Jacek, Vij, Ravi, Fiala, Mark, Valls, Davila Julio, Mądry, Krzysztof, Waszczuk-Gajda, Anna, Grosicki, Sebastian, Barchnicka, Agnieszka, Crusoe, Edvan, Hungria, Vania, Gentile, Massimo, Mele, Giuseppe, Ksieniewicz, Marcin, Vesole, David H., and Castillo, Jorge J.
- Published
- 2017
- Full Text
- View/download PDF
104. Epidemiology of Clostridium difficile infection : results of a hospital-based study in Krakow, Poland
- Author
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CZEPIEL, J., KĘDZIERSKA, J., BIESIADA, G., BIRCZYŃSKA, M., PERUCKI, W., NOWAK, P., and GARLICKI, A.
- Published
- 2015
105. Decreased Expression of the High Mobility Group Box 1 (HMGB1) Gene in Peripheral Blood in Patients with Mild or Moderate Clostridioides difficile Infection
- Author
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Jacek Czepiel, Grażyna Biesiada, Ewelina Pitera, Paweł P. Wołkow, Mateusz Michalak, and Aleksander Garlicki
- Subjects
genetic ,infection ,inflammation ,pathogenesis ,Biology (General) ,QH301-705.5 - Abstract
Cytokines are mediators of inflammation induced in the course of Clostridioides difficile infection (CDI). High Mobility Group Box 1 (HMGB1) is a cytokine playing an important role in the pathogenesis of numerous inflammatory and autoimmune diseases. The aim of the study was to assess the HMGB1 gene expression in the course of CDI. We have performed a prospective case-control study- including 55 adult patients, among them 27 with CDI, who were hospitalized from October 2018 to February 2020 and 28 healthy volunteers. We assessed: a complete blood count with differential leukocyte count, blood creatinine, albumin, and C-reactive protein (CRP) levels. Then, the expression of the HMGB1 gene was evaluated using quantitative Real-Time PCR. Patients with CDI were found to have a significant increase in white blood cells (WBC), neutrophil count, and CRP levels, they also exhibited decreased levels of albumin compared with controls. The HMGB1 gene expression was significantly lower among patients with CDI compared with the control group and significantly, inversely correlated with CRP level in blood. In conclusion, we have observed a decreased expression of the HMGB1 gene in peripheral blood of patients with mild or moderate CDI, which hypothetically could reflect their diminished capability to fight the pathogen.
- Published
- 2020
- Full Text
- View/download PDF
106. Διερεύνηση των σχέσεων της γονικότητας με την εκδήλωση τελειοθηρίας σε φοιτητικό πληθυσμό
- Author
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Diana Czepiel and Σπυρίδων Τάνταρος
- Subjects
Psychology ,BF1-990 - Abstract
Basirion, Z., Majid, R. A., & Jelas, Z. M. (2014). Big five personality factors, perceived parenting styles, and perfectionism among academically gifted students. Asian Social Science, 10(4), 8-15. doi:10.5539/ass.v10n4p8 Baumrind, D. (1971). Current patterns of parental authority. Developmental Psychology, 4(1, Pt.2), 1-103. doi:10.1037/h0030372 Baumrind, D. (1991). The influence of parenting style on adolescent competence and substance use. Journal of Early Adolescence, 11(1), 56-95. doi:10.1177/0272431691111004 Besharat, M. A, Azizi, K., & Poursharifi, H. (2011). The relationship between parenting styles and children’s perfectionism in a sample of Iranian families. Procedia-Social and Behavioral Sciences, 15, 1280-1283. doi:10.1016/j. sbspro.2011.03.277 Beuckelaer, A. D., & Lievens, F. (2009) Measurement equivalence of paper-and-pencil and internet organizational surveys: A large scale examination in 16 countries. Applied Psychology, 58, 336-361. doi:10.1111/j.1464-0597.2008.00350.x Bieling, P. J., Israeli, A. L., & Antony, M. M. (2004). Is perfectionism good, bad, or both? Examining models of the perfectionism construct. Personality and Individual Differences, 36(6), 1373-1385. doi:10.1016/S0191-8869(03)00235-6 Buri, J. R. (1991). Parental authority questionnaire. Journal of Personality Assessment, 57(1), 110- 119. doi:10.1207/s15327752jpa5701_13 Burns, D. D. (1980). The perfectionist’s script for selfdefeat. Psychology Today, 14, 34-52. Craddock, A. E., Church, W., & Sands, A. (2009). Family of origin characteristics as predictors of perfectionism. Australian Journal of Psychology, 61(3), 136-144. doi:10.1080/00049530802239326 Damian, L. E., Stoeber, J., Negru, O., & Baban, A. (2013). On the development of perfectionism in adolescence: Perceived parental expectations predict longitudinal increases in socially prescribed perfectionism. Personality and Individual Differences, 55(6), 688-693. doi:10.1016/j.paid.2013.05.021 Diamantopoulou, G., & Platsidou, M. (2014). Factorial validity and psychometric properties of the greek version of the Almost Perfect Scale-Revised (APS-R). Hellenic Journal of Psychology, 11, 123-137. Enns, M. W., & Cox, B. J. (2002). The nature and assessment of perfectionism: Α critical analysis. In G. L. Flett, & P. L. Hewitt (Eds.), Perfectionism: Theory, Research, and Treatment (pp. 33-62). Washington, DC: American Psychological Association. doi:10.1037/10458-002 Flett, G. L., Hewitt, P. L., & Singer, A. (1995). Perfectionism and parental authority styles. Individual Psychology: Journal of Adlerian Theory, Research & Practice, 51(1), 50-60. Flett, G.L., & Hewitt, P.L. (2002). Perfectionism and maladjustment: An overview of theoretical, definitional, and treatment issues. In G. L. Flett, & P. L. Hewitt (Eds.), Perfectionism: Theory, research, and treatment (pp. 5-13). Washington, DC: American Psychological Association. doi. org/10.1037/10458-001 Flett, G. L., Hewitt, P. L., Oliver, J. M., & Macdonald, S. (2002). Perfectionism in children and their parents: A developmental analysis. In G. L. Flett, & P. L. Hewitt (Eds.), Perfectionism: Theory, Research, and Treatment (pp. 89-132). Washington, DC: American Psychological Association. doi:10.1037/10458-004 Frost, R. O., Heimberg, R. G., Holt, C. S., Mattia, J. I., & Neubauer, A. L. (1993). A comparison of two measures of perfectionism. Personality and Individual Differences, 14(1), 119-126. doi:10.1016/0191-8869(93)90181-2 Frost, R. O., Marten, P., Lahart, C., & Rosenblate, R. (1990). The dimensions of perfectionism. Cognitive Therapy and Research, 14(5), 449-468. doi:10.1007/BF01172967 Gilman, R., & Ashby, J. S. (2003). Multidimensional perfectionism in a sample of middle school students: An exploratory investigation. Psychology in the Schools, 40(6), 677-689. doi:10.1002/pits.10125 Gong, X., Fletcher, K. L., & Bolin, J. H. (2015). Dimensions of perfectionism mediate the relationship between parenting styles and coping. Journal of Counseling & Development, 93, 259-268. doi:10.1002/jcad.12024 Gosling, S. D., Vazire, S., Srivastava, S., & John, O. P. (2004). Should we trust web-based studies? A comparative analysis of six preconceptions about internet questionnaires. American Psychologist, 59(2), 93-104. doi:10.1037/0003-066X.59.2.93 Hamachek, D. E. (1978). Psychodynamics of normal and neurotic perfectionism. Psychology: A Journal of Human Behavior, 15(1), 27-33. Hewitt, P. L., & Flett, G. L. (1990). Perfectionism and depression: A multidimensional analysis. Journal of Social Behavior and Personality, 5, 423-438. Hibbard, D. R., Walton, G. E., & State, C. (2012). Where does perfectionism come from? A qualitative investigation of perfectionists and nonperfectionists. Social Behavior and Personality, 40(7), 1121-1122. doi:10.2224/ sbp.2012.40.7.1121 Hibbard, D. R., & Walton, G. E. (2014). Exploring the development of perfectionism: The influence of parenting style and gender. Social Behavior and Personality: An International Journal, 42(2), 269- 278. doi:10.2224/sbp.2014.42.2.269 Hollender, M. H.(1965). Perfectionism . Comprehensive Psychiatry, 6, 94-103. Joinson, A. (1999). Social desirability, anonymity, and Intemet-based questionnaires. Behavior Research Methods, Instruments, & Computers, 31(3), 433-438. Kawamura, K. Y., Frost, R. O., & Harmatz, M. G. (2002). The relationship of perceived parenting styles to perfectionism. Personality and Individual Differences, 32(2), 317-327. doi:10.1016/S0191- 8869(01)00026-5 Knapp, H., & Kirk, S. A. (2003). Using pencil and paper, internet and touch-tone phones for self-administered surveys: Does methodology matter? Computers in Human Behavior, 19(1), 117-134. doi:10.1016/S0747-5632(02)00008-0 Kontrimiene, S. (2014). Rrelationships between adaptive and maladaptive perfectionism and perceived parenting styles in a sample of university students. Acta Paedagogica Vilnensia, 33, 96-115. Lewis, I. M., Watson, B. C., & White, K. M. (2009). Internet versus paper-and-pencil survey methods in psychological experiments: Equivalence testing of participant responses to health-related messages. Australian Journal of Psychology, 61(2), 107-116. doi:10.1080/00049530802105865 Methikalam, B., Wang, K. T., Slaney, R. B., & Yeung, J. G. (2015). Asian values, personal and family perfectionism, and mental health among Asian Indians in the United States. Asian American Journal of Psychology, 6(3), 223-232. doi:10.1037/aap0000023 Miller, A. L., Lambert, A. D., & Speirs Neumeister, K. L. (2012). Parenting style, perfectionism, and creativity in high-ability and high-achieving young adults. Journal for the Education of the Gifted, 35(4), 344-365. doi:10.1177/0162353212459257 Miller, A. L., & Speirs Neumeister, K. L. (2017). Journal of Advanced Academics, 28(4), 313-344. doi:10.1177/1932202X17730567 Missildine, W. H. (1963). Your inner child of the past. New York: Simon & Schuster. Olson, J. (2012). Parenting style and its relationship to perfectionism (Doctoral dissertation). Retrieved from ProQuest Dissertations Publishing. Ortega, N. E., Wang, K. T., Slaney, R. B., Hayes, J. A., & Morales, A. (2013). Personal and Familial Aspects of Perfectionism in Latino/a Students. The Counselling Psychologist, 42(3), 406-427. doi:10.1177/0011000012473166 Pacht, A. R. (1984). Reflections on perfection. American Psychologist, 39(4), 386-390. doi:10.1037/0003-066X.39.4.386 Παπάζογλου, Σ. (2018). Ιδιότυποι Τρόποι Απόκρισης: Σύγκριση μεταξύ παραδοσιακών συνθηκών μέ- τρησης και συνθηκών συμμετοχής σε διαδικτυα- κή έρευνα. (Αδημοσίευτη διδακτορική διατριβή). Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθη- νών, Αθήνα, Ελλάδα. Pastor, D. A. (2010). Cluster analysis. In G. R. Hancock & R. O. Mueller (Eds.), Quantitative methods in the social and behavioral sciences: A guide for researchers and reviewers (pp. 41-54). New York, NY: Taylor & Francis. Rice, K. G., Ashby, J. S., & Gilman, R. (2011). C l a s s i f y i n g a d o l e s c e n t p e r f e c t i o n i s t s . Psychological Assessment, 23(3), 563-577. doi:10.1037/a0022482 Rice, K. G., & Slaney, R. B. (2002). Clusters of perfectionists: Two studies of emotional adjustment and academic achievement. Measurement and Evaluation in Counselling and Development, 35(1), 35-48. Shih, T-H., & Fan, X. (2008). Comparing response rates from web and mail surveys: A metaanalysis. Field Methods, 20(3), 249-271. doi:10.1177/1525822X08317085 Slade, P. D., & Owens, R. (1998). A dual process model of perfectionism based on reinforcement theory. Behavior Modification, 22, 372-390. doi:10.1177/01454455980223010 Slaney, R. B., Mobley, M., Trippi, J., Ashby, J., & Johnson, D. G. (1996). The Almost Perfect Scale-Revised. Unpublished manuscript, The Pennsylvania State University, University Park, PA. Slaney, R., Rice, K., Mobley, M., Trippi, J., & Ashby, J. S. (2001). The Revised Almost Perfect Scale. Measurement and Evaluation in Counseling and Development, 34(3), 130-145. Slaney, R. B., Rice, K. G., & Ashby, J. S. (2002). A programmatic approach to measuring perfectionism: The Almost Perfect Scale. In G. L. Flett & P. L. Hewitt (Eds.), Perfectionism: Theory, research, and treatment (pp. 63-88). Washington, DC: American Psychological Association. doi:10.1037/10458-003 Soysa, C. K., & Weiss, A. (2014). Mediating perceived parenting styles-test anxiety relationships: Academic procrastination and maladaptive perfectionism. Learning and Individual Differences, 34, 77-85. doi:10.1016/j.lindif.2014.05.004 Speirs Neumeister, K. L. (2004). Factors influencing the development of perfectionism in gifted college students. Gifted Child Quarterly, 48(4), 259-274. doi: 10.1177/001698620404800402 Τσαούσης, Ι. (2002). Το γονεϊκό μοντέλο διαπαιδα- γώγησης και η αυτοεκτίμηση του μαθητή ως μεταβλητές εμφάνισης προβληματικής συμπε- ριφοράς στο περιβάλλον του σχολείου. Στο Ν. Πολεμικός, Μ. Καϊλα & Φ. Καλαβάσης (Επιμ.), Εκπαιδευτική, Οικογενειακή και Πολιτική Ψυχο- παθολογία (σσ. 274-303). Αθήνα: Ατραπός. Walton, G. E., Hibbard, D. R., Coughlin, C., & Coyl- Shepherd, D. D. (2018). Parenting, personality, and culture as predictors of perfectionism. Current Psychology(January), 1-13. doi:10.1007/ s12144-018-9793-y Wang, K. T. (2010). The Family Almost Perfect Scale: Development, psychometric properties, and comparing Asian and European Americans. Asian American Journal of Psychology, 1(3), 186- 199. doi:10.1037/a0020732 Wang, K. T., Methikalam, B., & Slaney, R. B. (2010). Family Almost Perfect Scale. Unpublished manuscript, The Pennsylvania State University, University Park, PA. Wang, K. T. (2012). Personal and family perfectionism of Taiwanese college students: Relationships with depression, self-esteem, achievement motivation and academic grades. Interntional Journal of Psychology, 47(4), 305- 314. doi: 10.1080/00207594.2011.626050 Weigold, A., Weigold, I. K., & Russell, E. J. (2013). Examination of the equivalence of self-report survey-based paper-and-pencil and internet data collection methods. Psychological Methods, 18(1), 53-70. doi:10.1037/a0031607 Basirion, Z., Majid, R. A., & Jelas, Z. M. (2014). Big five personality factors, perceived parenting styles, and perfectionism among academically gifted students. Asian Social Science, 10(4), 8-15. doi:10.5539/ass.v10n4p8 Baumrind, D. (1971). Current patterns of parental authority. Developmental Psychology, 4(1, Pt.2), 1-103. doi:10.1037/h0030372 Baumrind, D. (1991). The influence of parenting style on adolescent competence and substance use. Journal of Early Adolescence, 11(1), 56-95. doi:10.1177/0272431691111004 Besharat, M. A, Azizi, K., & Poursharifi, H. (2011). The relationship between parenting styles and children’s perfectionism in a sample of Iranian families. Procedia-Social and Behavioral Sciences, 15, 1280-1283. doi:10.1016/j. sbspro.2011.03.277 Beuckelaer, A. D., & Lievens, F. (2009) Measurement equivalence of paper-and-pencil and internet organizational surveys: A large scale examination in 16 countries. Applied Psychology, 58, 336-361. doi:10.1111/j.1464-0597.2008.00350.x Bieling, P. J., Israeli, A. L., & Antony, M. M. (2004). Is perfectionism good, bad, or both? Examining models of the perfectionism construct. Personality and Individual Differences, 36(6), 1373-1385. doi:10.1016/S0191-8869(03)00235-6 Buri, J. R. (1991). Parental authority questionnaire. Journal of Personality Assessment, 57(1), 110- 119. doi:10.1207/s15327752jpa5701_13 Burns, D. D. (1980). The perfectionist’s script for selfdefeat. Psychology Today, 14, 34-52. Craddock, A. E., Church, W., & Sands, A. (2009). Family of origin characteristics as predictors of perfectionism. Australian Journal of Psychology, 61(3), 136-144. doi:10.1080/00049530802239326 Damian, L. E., Stoeber, J., Negru, O., & Baban, A. (2013). On the development of perfectionism in adolescence: Perceived parental expectations predict longitudinal increases in socially prescribed perfectionism. Personality and Individual Differences, 55(6), 688-693. doi:10.1016/j.paid.2013.05.021 Diamantopoulou, G., & Platsidou, M. (2014). Factorial validity and psychometric properties of the greek version of the Almost Perfect Scale-Revised (APS-R). Hellenic Journal of Psychology, 11, 123-137. Enns, M. W., & Cox, B. J. (2002). The nature and assessment of perfectionism: Α critical analysis. In G. L. Flett, & P. L. Hewitt (Eds.), Perfectionism: Theory, Research, and Treatment (pp. 33-62). Washington, DC: American Psychological Association. doi:10.1037/10458-002 Flett, G. L., Hewitt, P. L., & Singer, A. (1995). Perfectionism and parental authority styles. Individual Psychology: Journal of Adlerian Theory, Research & Practice, 51(1), 50-60. Flett, G.L., & Hewitt, P.L. (2002). Perfectionism and maladjustment: An overview of theoretical, definitional, and treatment issues. In G. L. Flett, & P. L. Hewitt (Eds.), Perfectionism: Theory, research, and treatment (pp. 5-13). Washington, DC: American Psychological Association. doi. org/10.1037/10458-001 Flett, G. L., Hewitt, P. L., Oliver, J. M., & Macdonald, S. (2002). Perfectionism in children and their parents: A developmental analysis. In G. L. Flett, & P. L. Hewitt (Eds.), Perfectionism: Theory, Research, and Treatment (pp. 89-132). Washington, DC: American Psychological Association. doi:10.1037/10458-004 Frost, R. O., Heimberg, R. G., Holt, C. S., Mattia, J. I., & Neubauer, A. L. (1993). A comparison of two measures of perfectionism. Personality and Individual Differences, 14(1), 119-126. doi:10.1016/0191-8869(93)90181-2 Frost, R. O., Marten, P., Lahart, C., & Rosenblate, R. (1990). The dimensions of perfectionism. Cognitive Therapy and Research, 14(5), 449-468. doi:10.1007/BF01172967 Gilman, R., & Ashby, J. S. (2003). Multidimensional perfectionism in a sample of middle school students: An exploratory investigation. Psychology in the Schools, 40(6), 677-689. doi:10.1002/pits.10125 Gong, X., Fletcher, K. L., & Bolin, J. H. (2015). Dimensions of perfectionism mediate the relationship between parenting styles and coping. Journal of Counseling & Development, 93, 259-268. doi:10.1002/jcad.12024 Gosling, S. D., Vazire, S., Srivastava, S., & John, O. P. (2004). Should we trust web-based studies? A comparative analysis of six preconceptions about internet questionnaires. American Psychologist, 59(2), 93-104. doi:10.1037/0003-066X.59.2.93 Hamachek, D. E. (1978). Psychodynamics of normal and neurotic perfectionism. Psychology: A Journal of Human Behavior, 15(1), 27-33. Hewitt, P. L., & Flett, G. L. (1990). Perfectionism and depression: A multidimensional analysis. Journal of Social Behavior and Personality, 5, 423-438. Hibbard, D. R., Walton, G. E., & State, C. (2012). Where does perfectionism come from? A qualitative investigation of perfectionists and nonperfectionists. Social Behavior and Personality, 40(7), 1121-1122. doi:10.2224/ sbp.2012.40.7.1121 Hibbard, D. R., & Walton, G. E. (2014). Exploring the development of perfectionism: The influence of parenting style and gender. Social Behavior and Personality: An International Journal, 42(2), 269- 278. doi:10.2224/sbp.2014.42.2.269 Hollender, M. H.(1965). Perfectionism . Comprehensive Psychiatry, 6, 94-103. Joinson, A. (1999). Social desirability, anonymity, and Intemet-based questionnaires. Behavior Research Methods, Instruments, & Computers, 31(3), 433-438. Kawamura, K. Y., Frost, R. O., & Harmatz, M. G. (2002). The relationship of perceived parenting styles to perfectionism. Personality and Individual Differences, 32(2), 317-327. doi:10.1016/S0191- 8869(01)00026-5 Knapp, H., & Kirk, S. A. (2003). Using pencil and paper, internet and touch-tone phones for self-administered surveys: Does methodology matter? Computers in Human Behavior, 19(1), 117-134. doi:10.1016/S0747-5632(02)00008-0 Kontrimiene, S. (2014). Rrelationships between adaptive and maladaptive perfectionism and perceived parenting styles in a sample of university students. Acta Paedagogica Vilnensia, 33, 96-115. Lewis, I. M., Watson, B. C., & White, K. M. (2009). Internet versus paper-and-pencil survey methods in psychological experiments: Equivalence testing of participant responses to health-related messages. Australian Journal of Psychology, 61(2), 107-116. doi:10.1080/00049530802105865 Methikalam, B., Wang, K. T., Slaney, R. B., & Yeung, J. G. (2015). Asian values, personal and family perfectionism, and mental health among Asian Indians in the United States. Asian American Journal of Psychology, 6(3), 223-232. doi:10.1037/aap0000023 Miller, A. L., Lambert, A. D., & Speirs Neumeister, K. L. (2012). Parenting style, perfectionism, and creativity in high-ability and high-achieving young adults. Journal for the Education of the Gifted, 35(4), 344-365. doi:10.1177/0162353212459257 Miller, A. L., & Speirs Neumeister, K. L. (2017). Journal of Advanced Academics, 28(4), 313-344. doi:10.1177/1932202X17730567 Missildine, W. H. (1963). Your inner child of the past. New York: Simon & Schuster. Olson, J. (2012). Parenting style and its relationship to perfectionism (Doctoral dissertation). Retrieved from ProQuest Dissertations Publishing. Ortega, N. E., Wang, K. T., Slaney, R. B., Hayes, J. A., & Morales, A. (2013). Personal and Familial Aspects of Perfectionism in Latino/a Students. The Counselling Psychologist, 42(3), 406-427. doi:10.1177/0011000012473166 Pacht, A. R. (1984). Reflections on perfection. AmericanPsychologist, 39(4), 386-390. doi:10.1037/0003-066X.39.4.386 Παπάζογλου, Σ. (2018). Ιδιότυποι Τρόποι Απόκρισης: Σύγκριση μεταξύ παραδοσιακών συνθηκών μέ- τρησης και συνθηκών συμμετοχής σε διαδικτυα- κή έρευνα. (Αδημοσίευτη διδακτορική διατριβή). Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθη- νών, Αθήνα, Ελλάδα. Pastor, D. A. (2010). Cluster analysis. In G. R. Hancock & R. O. Mueller (Eds.), Quantitative methods in the social and behavioral sciences: A guide for researchers and reviewers (pp. 41-54). New York, NY: Taylor & Francis. Rice, K. G., Ashby, J. S., & Gilman, R. (2011). C l a s s i f y i n g a d o l e s c e n t p e r f e c t i o n i s t s . Psychological Assessment, 23(3), 563-577. doi:10.1037/a0022482 Rice, K. G., & Slaney, R. B. (2002). Clusters of perfectionists: Two studies of emotional adjustment and academic achievement. Measurement and Evaluation in Counselling and Development, 35(1), 35-48. Shih, T-H., & Fan, X. (2008). Comparing response rates from web and mail surveys: A metaanalysis. Field Methods, 20(3), 249-271. doi:10.1177/1525822X08317085 Slade, P. D., & Owens, R. (1998). A dual process model of perfectionism based on reinforcement theory. Behavior Modification, 22, 372-390. doi:10.1177/01454455980223010 Slaney, R. B., Mobley, M., Trippi, J., Ashby, J., & Johnson, D. G. (1996). The Almost Perfect Scale-Revised. Unpublished manuscript, The Pennsylvania State University, University Park, PA. Slaney, R., Rice, K., Mobley, M., Trippi, J., & Ashby, J. S. (2001). The Revised Almost Perfect Scale. Measurement and Evaluation in Counseling and Development, 34(3), 130-145. Slaney, R. B., Rice, K. G., & Ashby, J. S. (2002). A programmatic approach to measuring perfectionism: The Almost Perfect Scale. In G. L. Flett & P. L. Hewitt (Eds.), Perfectionism: Theory, research, and treatment (pp. 63-88). Washington, DC: American Psychological Association. doi:10.1037/10458-003 Soysa, C. K., & Weiss, A. (2014). Mediating perceived parenting styles-test anxiety relationships: Academic procrastination and maladaptive perfectionism. Learning and Individual Differences, 34, 77-85. doi:10.1016/j.lindif.2014.05.004 Speirs Neumeister, K. L. (2004). Factors influencing the development of perfectionism in gifted college students. GiftedChildQuarterly, 48(4), 259-274. doi: 10.1177/001698620404800402 Τσαούσης, Ι. (2002). Το γονεϊκό μοντέλο διαπαιδα- γώγησης και η αυτοεκτίμηση του μαθητή ως μεταβλητές εμφάνισης προβληματικής συμπε- ριφοράς στο περιβάλλον του σχολείου. Στο Ν. Πολεμικός, Μ. Καϊλα & Φ. Καλαβάσης (Επιμ.), Εκπαιδευτική, Οικογενειακή και Πολιτική Ψυχο- παθολογία (σσ. 274-303). Αθήνα: Ατραπός. Walton, G. E., Hibbard, D. R., Coughlin, C., & Coyl- Shepherd, D. D. (2018). Parenting, personality, and culture as predictors of perfectionism. Current Psychology(January), 1-13. doi:10.1007/ s12144-018-9793-y Wang, K. T. (2010). The Family Almost Perfect Scale: Development, psychometric properties, and comparing Asian and European Americans. Asian American Journal of Psychology, 1(3), 186- 199. doi:10.1037/a0020732 Wang, K. T., Methikalam, B., & Slaney, R. B. (2010). Family Almost Perfect Scale. Unpublished manuscript, The Pennsylvania State University, University Park, PA. Wang, K. T. (2012). Personal and family perfectionism of Taiwanese college students: Relationships with depression, self-esteem, achievement motivation and academic grades. Interntional Journal of Psychology, 47(4), 305- 314. doi: 10.1080/00207594.2011.626050 Weigold, A., Weigold, I. K., & Russell, E. J. (2013). Examination of the equivalence of self-report survey-based paper-and-pencil and internet data collection methods. Psychological Methods, 18(1), 53-70. doi:10.1037/a0031607
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- 2018
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107. Horacio y Sannazaro en las dos odas inéditas de Garcilaso de la Vega
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Czepiel, M
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- 2023
108. The negative power of music: Effects of disliked music on psychophysiology
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Julia Merrill, Taren-Ida Ackermann, and Anna Czepiel
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While previous research has shown the positive effects of music listening in response to one’s favorite music, the negative effects of one’s most disliked music have not gained much attention. Contra to studies on musical chills, in the current study, participants listened to three self-selected disliked musical pieces which evoked highly unpleasant feelings. As a contrast, three musical pieces were individually selected for each participant based on neutral liking ratings they provided on other participants’ music. During music listening, real-time ratings of subjective (dis)pleasure and simultaneous recordings of peripheral measures were obtained. Results show that compared to neutral music, listening to disliked music evokes physiological reactions reflecting higher arousal (heart rate, skin conductance response, body temperature), disgust (levator labii muscle), anger (corrugator supercilii muscle), distress and grimacing (zygomaticus major muscle). The differences between conditions were most prominent during “very unpleasant” real-time ratings, showing peak responses for the disliked music. Hence, disliked music leads to a strong response of physiological arousal and facial expression, reflecting the listener’s attitude toward the music and the physiologically strenuous effect of listening to one’s disliked music.
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- 2023
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109. Investigating the genetic diversity of H5 avian influenza in the UK 2020-2022
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Byrne, A. M., James, J., Mollett, B. C., Meyer, S. M., Lewis, T., Czepiel, M., Seekings, A. H., Mahmood, S., Thomas, S. S., Ross, C. S., Byrne, D. J., McMenamy, M. J., Bailie, V., Lemon, K., Hansen, R. D., Falchieri, M., Lewis, N. S., Reid, S. M., Brown, I. H., and Banyard, A. C.
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Since 2020, the UK and Europe, have experienced annual epizootics of high pathogenicity avian influenza virus (HPAIV). The first during autumn/winter 2020/21 involved the detected with six H5Nx subtypes although H5N8 HPAIV dominated in the UK. Whilst genetic assessment of the H5N8 HPAIVs within the UK demonstrated relative homogeneity, there was a background of other genotypes circulating at a lower degree with different neuraminidase and internal genes. Following a small number of summer detections of H5N1 in wild birds over the summer of 2021, autumn/winter 2021/22 saw another European H5 HPAIV epizootic, that has dwarfed the prior epizootic. This second epizootic was dominated almost exclusively by H5N1 HPAIV, although six distinct genotypes were defined. We have used genetic analysis to evaluate the emergence of different genotypes and proposed reassortment events that have been observed. The existing data suggests that the H5N1 circulating in Europe during late 2020, continued to circulate in wild birds throughout 2021, with minimal adaptation, but has then gone on to reassort with AIVs in the wild bird population. We have undertaken an in-depth genetic assessment of H5 HPAIVs detected in the UK, over the last two winter seasons and demonstrate the utility of in-depth genetic analyses in defining the diversity of H5 HPAIVs circulating in avian species, the potential for zoonotic risk and whether incidents of lateral spread can be defined over independent incursion of infection from wild birds. Key supporting data for mitigation activities. ImportanceHigh pathogenicity avian influenza virus (HPAIV) outbreaks devastate avian species across all sectors having both economic and ecological impacts through mortalities in poultry and wild birds, respectively. These viruses can also represent a significant zoonotic risk. Since 2020, the UK has experienced two successive outbreaks of H5 HPAIV. Whilst H5N8 HPAIV was predominant during the 2020/21 outbreak, other H5 subtypes were also detected. The following year there was a shift in subtype dominance to H5N1 HPAIV, but multiple H5N1 genotypes were detected. Through thorough utilisation of whole-genome sequencing, it was possible to track and characterise the genetic evolution of these H5 HPAIVs in UK poultry and wild birds. This has enabled us to assess the risk posed by these viruses at the poultry:wild bird and the avian:human interface and to investigate potential lateral spread between infected premises, a key factor in understanding threat to the commercial sector.
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- 2023
110. Changes in the liver proteome in apoE knockout mice exposed to inhalation of silica nanoparticles indicate mitochondrial damage and impairment of ER stress responses associated with microvesicular steatosis
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Kamila Stachyra, Anna Kiepura, Maciej Suski, Magdalena Ulatowska-Białas, Katarzyna Kuś, Anna Wiśniewska, Klaudia Czepiel, Grzegorz Majka, and Rafał Olszanecki
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Health, Toxicology and Mutagenesis ,Environmental Chemistry ,General Medicine ,Pollution - Abstract
The adverse effects of air pollution on the cardiovascular system have been well documented. Nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for cardiovascular events. However, the influence of exposure to airborne particles on the development of NAFLD is less recognised. The aim of this study was to investigate the impact of silica nanoparticles (SiNPs) on the development of liver steatosis. We used molecular and proteomic SWATH-MS methods to investigate the changes in the liver proteome of apolipoprotein E-knockout mice (apoE−/− mice) exposed to SiNPs for 4 months in a whole-body exposure chamber. Exposure to SiNPs evoked microvesicular liver steatosis in apoE−/− mice. Quantitative liver proteomics showed significant downregulation of ribosomal proteins and endoplasmic reticulum proteins. Gene expression analysis revealed a reduced level of proteins related to endoplasmic reticulum stress. Treatment with SiNPs decreased mitochondrial membrane potential and increased the production of reactive oxygen species in cultured HepG2 cells. This is the first report that inhalation exposure to SiNPs induces microvesicular steatosis and significant changes in the liver proteome in vivo. Our results highlight the important role of silica and point to the ER stress response and mitochondrial dysfunction as potential mechanisms responsible for the increase in fatty liver by SiNPs.
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- 2023
111. Aggressive abscesses in the head and neck region of probable odontogenic origin - two case reports
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Suska, Anna, Wiatr, Maciej, Lara, Martyna, Czepiel, Jacek, Składzień, Jacek, Sadowski, Piotr, Szpor, Joanna, and Czerniuk, Maciej Rafał
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broad-spectrum antibiotic therapy, microbial analysis, neck abscess, odontogenic infections, sinusitis - Published
- 2023
112. The negative power of music: Effects of disliked music on psychophysiology
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Merrill, Julia, primary, Ackermann, Taren-Ida, additional, and Czepiel, Anna, additional
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- 2023
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113. The Influence of the FFAR4 Agonist TUG-891 on Liver Steatosis in ApoE-Knockout Mice
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Kiepura, Anna, primary, Suski, Maciej, additional, Stachyra, Kamila, additional, Kuś, Katarzyna, additional, Czepiel, Klaudia, additional, Wiśniewska, Anna, additional, Ulatowska-Białas, Magdalena, additional, and Olszanecki, Rafał, additional
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- 2023
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114. “The obesity pandemic” in the COVID-19 pandemic – new treatment for an old problem
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Fabin-Czepiel, Kalina, primary, Pieczyńska-Chapuła, Karolina, additional, and Deja, Grażyna, additional
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- 2023
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115. I'm Smart, You're Dumb! Narcissistic Admiration and Rivalry Correlate with Self- and Other-Assessed Intelligence
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Zajenkowski, Marcin, primary, Gignac, Gilles, additional, Leniarska, Maria, additional, Turek, Anna, additional, and Czepiel, Zuzanna, additional
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- 2023
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116. Forensic veterinary use of the fly Lucilia sericata (Diptera: Calliphoridae) in the aspect of determining the time of death using tissues treated with calcium diclofenac
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CZEPIEL-MIL, KATARZYNA, primary, LISTOS, PIOTR, additional, STRYJECKI, ROBERT, additional, KOWALCZYK-PECKA, DANUTA, additional, and NIEOCZYM, MAREK, additional
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- 2023
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117. The Many Names of Fatty Liver Disease: Strengths and Limitations of Metabolic (Dysfunction)-Associated Fatty Liver Disease
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Czepiel, Kathryn S., primary and Stanford, Fatima Cody, additional
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- 2023
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118. Erythrocyte membrane fatty acids in multiple myeloma patients
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Jurczyszyn, Artur, Czepiel, Jacek, Gdula-Argasińska, Joanna, Czapkiewicz, Anna, Biesiada, Grażyna, Dróżdż, Mirosław, Perucki, William, and Castillo, Jorge J.
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- 2014
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119. The Association Between Chronic Hepatitis B, Chronic Hepatitis C, Sustained Liver Damage, and Features of Increased Cardiovascular Risk
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Mateusz Michalak, Marek Rajzer, Jacek Czepiel, Dorota Cibor, Grzegorz Bilo, Ewelina Pitera, Paweł Wołkow, Grażyna Biesiada, Gianfranco Parati, Aleksander Garlicki, Czepiel, J, Rajzer, M, Bilo, G, Parati, G, Biesiada, G, Cibor, D, Pitera, E, Wolkow, P, Michalak, M, and Garlicki, A
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medicine.medical_specialty ,PWV ,business.industry ,pulse wave velocity ,General Medicine ,Gastroenterology ,General Biochemistry, Genetics and Molecular Biology ,ADMA ,arterial stiffness ,Chronic hepatitis ,arterial stiffne ,Internal medicine ,HCV ,HBV ,medicine ,Liver damage ,business - Abstract
It is thought that chronic liver disease affects a person's risk of cardiovascular disease (CVD) development. The aim of this study was to assess the effect of Chronic Hepatitis B (HBV) infection, Chronic Hepatitis C (HCV) infection, and liver damage on cardiovascular risk and selected vascular parameters contributing to CVD risk. This case-control study included a group of 114 patients composed of 34 patients with HBV, 35 patients with HCV, and 45 patients as the control group. Cardiovascular risk was assessed by analyzing classic risk factors, and the SCORE system. The following arterial properties were analyzed using applanation tonometry with SphygmoCor Vx technology: central systolic blood pressure (cSBP), central pulse pressure, augmentation pressure, augmentation index, and carotid-femoral pulse wave velocity (PWV). Asymmetric dimethyloarginine (ADMA) blood levels were analyzed using ELISA as a marker of vascular function. In a univariable analysis we found no significant differences between the hepatitis B, hepatitis C, and control groups in terms of PWV (respectively: median 7.2 [Q25-Q75 6.4-8.5], 7.3 [6.9-8.7], 7.8 [6.5-8.9]), cSBP (115 [109-126], 118 [107-123], 116 [107-129]), ADMA (0.52 [0.47-0.60], 0.53 [0.45-0.62], 0.58 [0.51-0.63]), SCORE (0 [0-1], 0 [0-2], 0 [0-2]). No significant differences in cardiovascular variables were observed between cirrhotic and non-cirrhotic patients. A multivariable analysis confirmed the above findings. (PWV, p=0 . 29; cSBP, p=0.26; ADMA, p=0.19). We concluded that chronic hepatitis B or C was not independently associated with an adverse cardiovascular risk profile nor with an unfavorable pattern of vascular parameters contributing to CVD risk in our study population, even in the case of liver cirrhosis. The same was true for blood ADMA levels.
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- 2021
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120. Human erythrocytes analyzed by generalized 2D Raman correlation spectroscopy
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Wesełucha-Birczyńska, Aleksandra, Kozicki, Mateusz, Czepiel, Jacek, Łabanowska, Maria, Nowak, Piotr, Kowalczyk, Grzegorz, Kurdziel, Magdalena, Birczyńska, Malwina, Biesiada, Grażyna, Mach, Tomasz, and Garlicki, Aleksander
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- 2014
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121. Transcriptome-derived investigation of biosynthesis of quinolizidine alkaloids in narrow-leafed lupin (Lupinus angustifolius L.) highlights candidate genes linked to iucundus locus
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Kroc, Magdalena, Koczyk, Grzegorz, Kamel, Katarzyna A., Czepiel, Katarzyna, Fedorowicz-Strońska, Olga, Krajewski, Paweł, Kosińska, Joanna, Podkowiński, Jan, Wilczura, Paulina, and Święcicki, Wojciech
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- 2019
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122. Characterization and comparison of osteoblasts derived from mouse embryonic stem cells and induced pluripotent stem cells
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Ma, Ming-San, Kannan, Vishnu, de Vries, Anneriek E., Czepiel, Marcin, Wesseling, Evelyn M., Balasubramaniyan, Veerakumar, Kuijer, Roel, Vissink, Arjan, Copray, Sjef C. V. M., and Raghoebar, Gerry M.
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- 2017
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123. Investigating the genetic diversity of H5 avian influenza in the UK 2020-2022
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Alexander MP Byrne, Joe James, Benjamin C Mollett, Stephanie M Meyer, Thomas Lewis, Magdalena Czepiel, Amanda H Seekings, Sahar Mahmood, Saumya S Thomas, Craig S Ross, Dominic JF Byrne, Michael J McMenamy, Valerie Bailie, Ken Lemon, Rowena DE Hansen, Marco Falchieri, Nicola S Lewis, Scott M Reid, Ian H Brown, and Ashley C Banyard
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Since 2020, the UK and Europe, have experienced annual epizootics of high pathogenicity avian influenza virus (HPAIV). The first during autumn/winter 2020/21 involved the detected with six H5Nx subtypes although H5N8 HPAIV dominated in the UK. Whilst genetic assessment of the H5N8 HPAIVs within the UK demonstrated relative homogeneity, there was a background of other genotypes circulating at a lower degree with different neuraminidase and internal genes. Following a small number of summer detections of H5N1 in wild birds over the summer of 2021, autumn/winter 2021/22 saw another European H5 HPAIV epizootic, that has dwarfed the prior epizootic. This second epizootic was dominated almost exclusively by H5N1 HPAIV, although six distinct genotypes were defined. We have used genetic analysis to evaluate the emergence of different genotypes and proposed reassortment events that have been observed. The existing data suggests that the H5N1 circulating in Europe during late 2020, continued to circulate in wild birds throughout 2021, with minimal adaptation, but has then gone on to reassort with AIVs in the wild bird population. We have undertaken an in-depth genetic assessment of H5 HPAIVs detected in the UK, over the last two winter seasons and demonstrate the utility of in-depth genetic analyses in defining the diversity of H5 HPAIVs circulating in avian species, the potential for zoonotic risk and whether incidents of lateral spread can be defined over independent incursion of infection from wild birds. Key supporting data for mitigation activities.ImportanceHigh pathogenicity avian influenza virus (HPAIV) outbreaks devastate avian species across all sectors having both economic and ecological impacts through mortalities in poultry and wild birds, respectively. These viruses can also represent a significant zoonotic risk. Since 2020, the UK has experienced two successive outbreaks of H5 HPAIV. Whilst H5N8 HPAIV was predominant during the 2020/21 outbreak, other H5 subtypes were also detected. The following year there was a shift in subtype dominance to H5N1 HPAIV, but multiple H5N1 genotypes were detected. Through thorough utilisation of whole-genome sequencing, it was possible to track and characterise the genetic evolution of these H5 HPAIVs in UK poultry and wild birds. This has enabled us to assess the risk posed by these viruses at the poultry:wild bird and the avian:human interface and to investigate potential lateral spread between infected premises, a key factor in understanding threat to the commercial sector.
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- 2022
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124. Activation of cardiac macrophages, endothelial cells and fibroblasts in experimental autoimmune myocarditis
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K Tkacz, F Rolski, A Jazwa-Kusior, E Dzialo, M Czepiel, M Warszynska, K Weglarczyk, R Szatanek, M Siedlar, G Kania, and P Blyszczuk
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Cardiology and Cardiovascular Medicine - Abstract
Background/Introduction Inflammation of cardiac tissue, termed myocarditis, is a common cause of dilated cardiomyopathy associated with abnormal tissue remodeling, stiffening of ventricles and heart failure. Experimental autoimmune myocarditis (EAM) represents CD4+ T cell-dependent animal model of acute myocarditis followed by development of cardiomyopathy, cardiac fibrosis and systolic dysfunction. Purpose The aim of the study was to investigate the role of cardiac macrophages, endothelial cells and fibroblasts in myocarditis and post-inflammatory cardiomyopathy in mouse model of EAM. Methods EAM was induced in BALB/c mice by immunization with alpha myosin heavy chain and complete Freund's adjuvant. Reporter mice expressing EGFP under collagen type I promoter (Coll-EGFP), transgenic αSMA-TK mice with ganciclovir-inducible ablation of proliferating myofibroblasts and Rosa26-YFP/LysM-Cre and Rosa26-YFP/LysM-Cre/Tgfbr2 fl/fl with YFP expression and Tgfbr2 deletion in myeloid cell population were used in this study. Cardiac fibroblasts and macrophages were sorted using BD FACSAria™ II Cell Sorter and analyzed for the genome transcriptomics by RNA sequencing. Echocardiography was performed on Vevo 2100 Imaging System. Cardiac fibrosis was measured as percentage of fibrotic area using Trichrome Massons's staining and by hydroxyproline assay. Cardiac hypertrophy was analyzed as means of cross-sectional cardiomyocyte area. Monocytes and endobcells were analyzed using BD FACSCanto™ II flow cytometry. Results Cardiac fibroblasts in response to acute myocarditis (d21 of EAM) showed activation of immune processes (mainly chemokine production such as Ccl6, Ccl9, Cxcl2, Cxcl3, Cxcl5, Cxcl9, Cxcl13), cytoskeletal re-organization (Cxadr, F11r, Gdpd2, Krt8, Krt19, Ptk2b, Rac2, Rhov, Rnd1, S100a9, Spire2, Was) and upregulation of genes involved in extracellular matrix turnover (Bmp7, Kng2, Lgals3, Cthrc1, Cela1, Spn) including collagens. Ablation of myofibroblasts (between d21–40 of EAM) resulted in markedly reduced heart weight and cardiomyocyte hypertrophy, attenuated expression of genes related to hypertrophy (Acta1, Actc1, Bnp, Cfl2, Pdlim5), improved stroke volume, ejection fraction and cardiac output but did not prevent development of post-inflammatory cardiac fibrosis measured at d40 of EAM. Analysis of monocytes and endothelial cells indicated excessive production of type I collagen by these cells at d21. Analysis of cardiac macrophages pointed out TGF-β-dependent expression of cytokines (Ifn, Il23a, Il10, Il12b, Cxcl1, Tnf) and theirs receptors (Cxcr1, Ccr4) at d21 of EAM. Conclusions Acute myocarditis activates proinflammatory and profibrotic responses in cardiac resident cells. Our data suggest that cardiac myofibroblasts play a particularly important role in development of post-inflammatory cardiomyopathy and heart failure. Targeting cardiac myofibroblasts might therefore represent a novel therapeutic strategy in inflammatory heart disease. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): National Science Centre (Poland)
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- 2022
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125. Haploinsufficient Rock1+/− and Rock2+/− Mice Are Not Protected from Cardiac Inflammation and Postinflammatory Fibrosis in Experimental Autoimmune Myocarditis
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Karolina Tkacz, Filip Rolski, Marcin Czepiel, Edyta Działo, Maciej Siedlar, Urs Eriksson, Gabriela Kania, and Przemysław Błyszczuk
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rho-associated protein kinase ,rock1 ,rock2 ,experimental autoimmune myocarditis ,cardiac fibroblasts ,inflammatory cells ,tgf-β ,cardiac fibrosis ,Cytology ,QH573-671 - Abstract
Progressive cardiac fibrosis is a common cause of heart failure. Rho-associated, coiled-coil-containing protein kinases (ROCKs) have been shown to enhance fibrotic processes in the heart and in other organs. In this study, using wild-type, Rock1+/− and Rock2+/− haploinsufficient mice and mouse model of experimental autoimmune myocarditis (EAM) we addressed the role of ROCK1 and ROCK2 in development of myocarditis and postinflammatory fibrosis. We found that myocarditis severity was comparable in wild-type, Rock1+/− and Rock2+/− mice at day 21 of EAM. During the acute stage of the disease, hearts of Rock1+/− mice showed unaffected numbers of CD11b+CD36+ macrophages, CD11b+CD36−Ly6GhiLy6chi neutrophils, CD11b+CD36−Ly6G−Ly6chi inflammatory monocytes, CD11b+CD36−Ly6G−Ly6c− monocytes, CD11b+SiglecF+ eosinophils, CD11b+CD11c+ inflammatory dendritic cells and type I collagen-producing fibroblasts. Isolated Rock1+/− cardiac fibroblasts treated with transforming growth factor-beta (TGF-β) showed attenuated Smad2 and extracellular signal-regulated kinase (Erk) phosphorylations that were associated with impaired upregulation of smooth muscle actin alpha (αSMA) protein. In contrast to cardiac fibroblasts, expanded Rock1+/− heart inflammatory myeloid cells showed unaffected Smad2 activation but enhanced Erk phosphorylation following TGF-β treatment. Rock1+/− inflammatory cells responded to TGF-β by a reduced transcriptional profibrotic response and failed to upregulate αSMA and fibronectin at the protein levels. Unexpectedly, in the EAM model wild-type, Rock1+/− and Rock2+/− mice developed a similar extent of cardiac fibrosis at day 40. In addition, hearts of the wild-type and Rock1+/− mice showed comparable levels of cardiac vimentin, periostin and αSMA. In conclusion, despite the fact that ROCK1 regulates TGF-β-dependent profibrotic response, neither ROCK1 nor ROCK2 is critically involved in the development of postinflammatory fibrosis in the EAM model.
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- 2020
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126. Down‐Regulation of Dkk‐1 in Platelets of Patients With Axial Spondyloarthritis
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Przemyslaw Blyszczuk, Zofia Guła, Marcin Czepiel, Małgorzata Stec, Mariusz Korkosz, Jarosław Baran, and Maciej Siedlar
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Adult ,Blood Platelets ,Male ,musculoskeletal diseases ,medicine.medical_specialty ,Immunology ,Down-Regulation ,Rheumatology ,Megakaryocyte ,Downregulation and upregulation ,Internal medicine ,Spondylarthritis ,medicine ,Humans ,Immunology and Allergy ,Platelet ,In patient ,Axial spondyloarthritis ,Messenger RNA ,business.industry ,Wnt signaling pathway ,medicine.anatomical_structure ,Endocrinology ,DKK1 ,Intercellular Signaling Peptides and Proteins ,Female ,business - Abstract
OBJECTIVE Axial spondyloarthritis (SpA) is a chronic autoinflammatory disease with new bone formation, which is controlled by Wnt/β-catenin signaling. Dkk-1 is an inhibitor of the Wnt pathway, and in humans, platelets represent a major source of Dkk-1. This study was undertaken to investigate whether levels of Dkk-1 in serum and platelet expression of DKK1 messenger RNA (mRNA) and Dkk-1 protein are affected in patients with axial SpA compared to healthy controls. METHODS Forty-one patients with axial SpA and 35 healthy controls were enrolled in the study. Total serum Dkk-1 levels in all patients and healthy controls were measured by quantitative enzyme-linked immunosorbent assay. Platelet DKK1 mRNA was analyzed by quantitative reverse transcriptase-polymerase chain reaction in 20 patients with axial SpA and 20 controls, and Dkk-1 protein levels were measured by immunoblotting in 20 patients with axial SpA and 18 controls. RESULTS We found a lower concentration of Dkk-1 in the serum from patients with axial SpA compared to the serum from healthy controls (P < 0.0001). Furthermore, the expression of Dkk-1 was significantly reduced both at the transcriptional level (P < 0.04) and at the protein level (P < 0.007) in platelets isolated from the blood of patients with axial SpA. CONCLUSION Our preliminary observations suggest that dysfunction of the megakaryocyte/platelet axis might be responsible for reduced serum Dkk-1 levels in patients with axial SpA. Dkk-1 is down-regulated in the platelets of patients with axial SpA, a mechanism that might play a role in new bone formation.
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- 2021
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127. A pandemic recap: lessons we have learned
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Coccolini, F, Cicuttin, E, Cremonini, C, Tartaglia, D, Viaggi, B, Kuriyama, A, Picetti, E, Ball, C, Abu-Zidan, F, Ceresoli, M, Turri, B, Jain, S, Palombo, C, Guirao, X, Rodrigues, G, Gachabayov, M, Machado, F, Eftychios, L, Kanj, S, Di Carlo, I, Di Saverio, S, Khokha, V, Kirkpatrick, A, Massalou, D, Forfori, F, Corradi, F, Delibegovic, S, Machain Vega, G, Fantoni, M, Demetriades, D, Kapoor, G, Kluger, Y, Ansari, S, Maier, R, Leppaniemi, A, Hardcastle, T, Vereczkei, A, Karamagioli, E, Pikoulis, E, Pistello, M, Sakakushev, B, Navsaria, P, Galeiras, R, Yahya, A, Osipov, A, Dimitrov, E, Doklestic, K, Pisano, M, Malacarne, P, Carcoforo, P, Sibilla, M, Kryvoruchko, I, Bonavina, L, Kim, J, Shelat, V, Czepiel, J, Maseda, E, Marwah, S, Chirica, M, Biancofiore, G, Podda, M, Cobianchi, L, Ansaloni, L, Fugazzola, P, Seretis, C, Gomez, C, Tumietto, F, Malbrain, M, Reichert, M, Augustin, G, Amato, B, Puzziello, A, Hecker, A, Gemignani, A, Isik, A, Cucchetti, A, Nacoti, M, Kopelman, D, Mesina, C, Ghannam, W, Ben-Ishay, O, Dhingra, S, Coimbra, R, Moore, E, Cui, Y, Quiodettis, M, Bala, M, Testini, M, Diaz, J, Girardis, M, Biffl, W, Hecker, M, Sall, I, Boggi, U, Materazzi, G, Ghiadoni, L, Matsumoto, J, Zuidema, W, Ivatury, R, Enani, M, Litvin, A, Al-Hasan, M, Demetrashvili, Z, Baraket, O, Ordonez, C, Negoi, I, Kiguba, R, Memish, Z, Elmangory, M, Tolonen, M, Das, K, Ribeiro, J, O'Connor, D, Tan, B, Van Goor, H, Baral, S, De Simone, B, Corbella, D, Brambillasca, P, Scaglione, M, Basolo, F, De'Angelis, N, Bendinelli, C, Weber, D, Pagani, L, Monti, C, Baiocchi, G, Chiarugi, M, Catena, F, Sartelli, M, Coccolini F., Cicuttin E., Cremonini C., Tartaglia D., Viaggi B., Kuriyama A., Picetti E., Ball C., Abu-Zidan F., Ceresoli M., Turri B., Jain S., Palombo C., Guirao X., Rodrigues G., Gachabayov M., Machado F., Eftychios L., Kanj S. S., Di Carlo I., Di Saverio S., Khokha V., Kirkpatrick A., Massalou D., Forfori F., Corradi F., Delibegovic S., Machain Vega G. M., Fantoni M., Demetriades D., Kapoor G., Kluger Y., Ansari S., Maier R., Leppaniemi A., Hardcastle T., Vereczkei A., Karamagioli E., Pikoulis E., Pistello M., Sakakushev B. E., Navsaria P. H., Galeiras R., Yahya A. I., Osipov A. V., Dimitrov E., Doklestic K., Pisano M., Malacarne P., Carcoforo P., Sibilla M. G., Kryvoruchko I. A., Bonavina L., Kim J. I., Shelat V. G., Czepiel J., Maseda E., Marwah S., Chirica M., Biancofiore G., Podda M., Cobianchi L., Ansaloni L., Fugazzola P., Seretis C., Gomez C. A., Tumietto F., Malbrain M., Reichert M., Augustin G., Amato B., Puzziello A., Hecker A., Gemignani A., Isik A., Cucchetti A., Nacoti M., Kopelman D., Mesina C., Ghannam W., Ben-Ishay O., Dhingra S., Coimbra R., Moore E. E., Cui Y., Quiodettis M. A., Bala M., Testini M., Diaz J., Girardis M., Biffl W. L., Hecker M., Sall I., Boggi U., Materazzi G., Ghiadoni L., Matsumoto J., Zuidema W. P., Ivatury R., Enani M. A., Litvin A., Al-Hasan M. N., Demetrashvili Z., Baraket O., Ordonez C. A., Negoi I., Kiguba R., Memish Z. A., Elmangory M. M., Tolonen M., Das K., Ribeiro J., O'Connor D. B., Tan B. K., Van Goor H., Baral S., De Simone B., Corbella D., Brambillasca P., Scaglione M., Basolo F., De'Angelis N., Bendinelli C., Weber D., Pagani L., Monti C., Baiocchi G., Chiarugi M., Catena F., Sartelli M., Coccolini, F, Cicuttin, E, Cremonini, C, Tartaglia, D, Viaggi, B, Kuriyama, A, Picetti, E, Ball, C, Abu-Zidan, F, Ceresoli, M, Turri, B, Jain, S, Palombo, C, Guirao, X, Rodrigues, G, Gachabayov, M, Machado, F, Eftychios, L, Kanj, S, Di Carlo, I, Di Saverio, S, Khokha, V, Kirkpatrick, A, Massalou, D, Forfori, F, Corradi, F, Delibegovic, S, Machain Vega, G, Fantoni, M, Demetriades, D, Kapoor, G, Kluger, Y, Ansari, S, Maier, R, Leppaniemi, A, Hardcastle, T, Vereczkei, A, Karamagioli, E, Pikoulis, E, Pistello, M, Sakakushev, B, Navsaria, P, Galeiras, R, Yahya, A, Osipov, A, Dimitrov, E, Doklestic, K, Pisano, M, Malacarne, P, Carcoforo, P, Sibilla, M, Kryvoruchko, I, Bonavina, L, Kim, J, Shelat, V, Czepiel, J, Maseda, E, Marwah, S, Chirica, M, Biancofiore, G, Podda, M, Cobianchi, L, Ansaloni, L, Fugazzola, P, Seretis, C, Gomez, C, Tumietto, F, Malbrain, M, Reichert, M, Augustin, G, Amato, B, Puzziello, A, Hecker, A, Gemignani, A, Isik, A, Cucchetti, A, Nacoti, M, Kopelman, D, Mesina, C, Ghannam, W, Ben-Ishay, O, Dhingra, S, Coimbra, R, Moore, E, Cui, Y, Quiodettis, M, Bala, M, Testini, M, Diaz, J, Girardis, M, Biffl, W, Hecker, M, Sall, I, Boggi, U, Materazzi, G, Ghiadoni, L, Matsumoto, J, Zuidema, W, Ivatury, R, Enani, M, Litvin, A, Al-Hasan, M, Demetrashvili, Z, Baraket, O, Ordonez, C, Negoi, I, Kiguba, R, Memish, Z, Elmangory, M, Tolonen, M, Das, K, Ribeiro, J, O'Connor, D, Tan, B, Van Goor, H, Baral, S, De Simone, B, Corbella, D, Brambillasca, P, Scaglione, M, Basolo, F, De'Angelis, N, Bendinelli, C, Weber, D, Pagani, L, Monti, C, Baiocchi, G, Chiarugi, M, Catena, F, Sartelli, M, Coccolini F., Cicuttin E., Cremonini C., Tartaglia D., Viaggi B., Kuriyama A., Picetti E., Ball C., Abu-Zidan F., Ceresoli M., Turri B., Jain S., Palombo C., Guirao X., Rodrigues G., Gachabayov M., Machado F., Eftychios L., Kanj S. S., Di Carlo I., Di Saverio S., Khokha V., Kirkpatrick A., Massalou D., Forfori F., Corradi F., Delibegovic S., Machain Vega G. M., Fantoni M., Demetriades D., Kapoor G., Kluger Y., Ansari S., Maier R., Leppaniemi A., Hardcastle T., Vereczkei A., Karamagioli E., Pikoulis E., Pistello M., Sakakushev B. E., Navsaria P. H., Galeiras R., Yahya A. I., Osipov A. V., Dimitrov E., Doklestic K., Pisano M., Malacarne P., Carcoforo P., Sibilla M. G., Kryvoruchko I. A., Bonavina L., Kim J. I., Shelat V. G., Czepiel J., Maseda E., Marwah S., Chirica M., Biancofiore G., Podda M., Cobianchi L., Ansaloni L., Fugazzola P., Seretis C., Gomez C. A., Tumietto F., Malbrain M., Reichert M., Augustin G., Amato B., Puzziello A., Hecker A., Gemignani A., Isik A., Cucchetti A., Nacoti M., Kopelman D., Mesina C., Ghannam W., Ben-Ishay O., Dhingra S., Coimbra R., Moore E. E., Cui Y., Quiodettis M. A., Bala M., Testini M., Diaz J., Girardis M., Biffl W. L., Hecker M., Sall I., Boggi U., Materazzi G., Ghiadoni L., Matsumoto J., Zuidema W. P., Ivatury R., Enani M. A., Litvin A., Al-Hasan M. N., Demetrashvili Z., Baraket O., Ordonez C. A., Negoi I., Kiguba R., Memish Z. A., Elmangory M. M., Tolonen M., Das K., Ribeiro J., O'Connor D. B., Tan B. K., Van Goor H., Baral S., De Simone B., Corbella D., Brambillasca P., Scaglione M., Basolo F., De'Angelis N., Bendinelli C., Weber D., Pagani L., Monti C., Baiocchi G., Chiarugi M., Catena F., and Sartelli M.
- Abstract
On January 2020, the WHO Director General declared that the outbreak constitutes a Public Health Emergency of International Concern. The world has faced a worldwide spread crisis and is still dealing with it. The present paper represents a white paper concerning the tough lessons we have learned from the COVID-19 pandemic. Thus, an international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making. With the present paper, international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making.
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- 2021
128. Investigating the genetic diversity of H5 avian influenza in the UK 2020-2022
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Byrne, Alexander MP, primary, James, Joe, additional, Mollett, Benjamin C, additional, Meyer, Stephanie M, additional, Lewis, Thomas, additional, Czepiel, Magdalena, additional, Seekings, Amanda H, additional, Mahmood, Sahar, additional, Thomas, Saumya S, additional, Ross, Craig S, additional, Byrne, Dominic JF, additional, McMenamy, Michael J, additional, Bailie, Valerie, additional, Lemon, Ken, additional, Hansen, Rowena DE, additional, Falchieri, Marco, additional, Lewis, Nicola S, additional, Reid, Scott M, additional, Brown, Ian H, additional, and Banyard, Ashley C, additional
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- 2022
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129. Activation of cardiac macrophages, endothelial cells and fibroblasts in experimental autoimmune myocarditis
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Tkacz, K, primary, Rolski, F, additional, Jazwa-Kusior, A, additional, Dzialo, E, additional, Czepiel, M, additional, Warszynska, M, additional, Weglarczyk, K, additional, Szatanek, R, additional, Siedlar, M, additional, Kania, G, additional, and Blyszczuk, P, additional
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- 2022
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130. Przekleństwo pragnienia półptaka. Radykalizm polityczny według Bronisława Trentowskiego w kontekście współczesnym
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Anna Czepiel
- Abstract
Artykuł zawiera rozważania na temat eseju Bronisława Trentowskiego pt. „Radykalizm polityczny” z 1843 roku. Rozważania autorki dzielą się na cztery części: 1. Samodzielność ludzi i ożywienie polityki – dwie główne cechy „radykalizmu politycznego”; 2. Lud u Trentowskiego: masa czy wielość różnych jednostek?; 3. Diagnoza „radykała politycznego” a dzisiejsza spolaryzowana demokracja 4. Zakończenie: „demokratyzm” jako „przychodzenie do swego uczucia”. Autorka zauważa, że Trentowski wypracował argumentację, która dzisiaj naturalnie narzuca się zwolennikom demokracji partycypacyjnej – jak choćby zarzut wobec liberałów takich jak Benjamin Constant, że traktują wolność w sposób selektywny, dozwalając na nią w sferze prywatnej, ale już nie w sferze politycznej. Właśnie tę selektywność Trentowski zwie „półptakiem”. Ponadto argumentacja Trentowskiego pozwala uznać polityczną polaryzację za martwotę – „rządy rozumu” zamiast „rządów umysłu”.
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- 2021
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131. Bariatric surgery in the treatment of adolescent obesity: current perspectives in the United States
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Sujatha Seetharaman, Eftitan Y Akam, Fatima Cody Stanford, Sonali Malhotra, Ramya Sivasubramanian, Ashley Y. Shaw, and Kathryn S. Czepiel
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Pediatric Obesity ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Gastric Bypass ,Bariatric Surgery ,Stigma (botany) ,030209 endocrinology & metabolism ,Article ,Limited access ,03 medical and health sciences ,0302 clinical medicine ,Gastrectomy ,Weight loss ,Long term outcomes ,Humans ,Medicine ,Child ,business.industry ,Adolescent Obesity ,Perioperative ,medicine.disease ,Obesity ,United States ,Health equity ,Surgery ,030220 oncology & carcinogenesis ,Quality of Life ,medicine.symptom ,business - Abstract
INTRODUCTION: Rates of severe obesity in adolescents have increased at an alarming rate. Unfortunately, there are limited successful treatments for severe obesity in adolescents. Metabolic and bariatric surgery (MBS) is the most effective treatment available for adolescents with Class 2 and above severe obesity and has demonstrated variable degrees of sustained long-term weight loss which leads to resolution of multiple associated conditions and an improved quality of life. AREAS COVERED: We discuss the current landscape of MBS in adolescents and evidence to support its long-term safety and efficacy. A literature search through PubMed, ResearchGate and HOLLIS Harvard Library Online Catalog was performed from the date of inception until 3/15/2021. A combination of the following keywords was used: Pediatric metabolic/bariatric surgery; long term outcomes of Pediatric metabolic/bariatric surgery, perioperative assessment, pediatric metabolic/bariatric surgery barriers; attitudes toward metabolic/bariatric surgery. EXPERT OPINION: MBS is emerging as a safe and effective treatment strategy for adolescents with severe obesity, with recent studies demonstrating durable and sustainable weight loss. There remains an urgent need for longitudinal studies to assess durability of weight loss. Obesity stigma and bias, limited access to tertiary care centers, and skepticism around the treatment of obesity poses a major challenge.
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- 2021
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132. The Many Names of Fatty Liver Disease: Strengths and Limitations of Metabolic (Dysfunction)-Associated Fatty Liver Disease
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Kathryn Czepiel and Fatima Stanford
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Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Pediatrics, Perinatology and Child Health - Published
- 2023
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133. Aesthetic and physiological effects of naturalistic multimodal music listening
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Anna Czepiel, Lauren K Fink, Christoph Seibert, Mathias Scharinger, and Sonja A Kotz
- Abstract
Compared to audio only (AO) conditions, audiovisual (AV) information can enhance the aesthetic experience of a music performance. However, such beneficial multimodal effects have yet to be studied in naturalistic music performance settings. Further, peripheral physiological correlates of aesthetic experiences are not well-understood. Here, participants were invited to a concert hall for piano performances of Bach, Messiaen, and Beethoven, which were presented in two conditions: AV and AO. They rated their aesthetic experience (AE) after each piece (Experiment 1 and 2), while peripheral signals (cardiorespiratory measures, skin conductance, and facial muscle activity) were continuously measured (Experiment 2). Factor scores of AE were significantly higher in the AV condition in both experiments. LF/HF ratio, a heart rhythm that represents activation of the sympathetic nervous system, was higher in the AO condition, suggesting increased arousal, likely caused by less predictable sound onsets in the AO condition. We present partial evidence that breathing was faster and facial muscle activity was higher in the AV condition, suggesting that observing a performer's movements likely enhances motor mimicry in these more voluntary peripheral measures. Further, zygomaticus ('smiling') muscle activity was a significant predictor of AE. Thus, we suggest physiological measures are related to AE, but at different levels: the more involuntary measures (i.e., heart rhythms) may reflect more sensory aspects, while the more voluntary measures (i.e., muscular control of breathing and facial responses) may reflect the liking aspect of an AE. In summary, we replicate and extend previous findings that AV information enhances AE in a naturalistic music performance setting. We further show that a combination of self-report and peripheral measures benefit a meaningful assessment of AE in naturalistic music performance settings.
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- 2022
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134. Thrips (Thysanoptera, Insecta) of the Asteraceae family plants occurring in areas with different levels of anthropopressure in Lublin (Eastern Poland) / Wciornastki (Thysanoptera, Insecta) zebrane z miejsc o różnym stopniu antropopresji w Lublinie na roślinach z rodziny Asteraceae
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Czepiel-Mil Katarzyna and Kowalczyk-Pecka Danuta
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thysanoptera ,thrips ,urban environment ,asteraceae ,anthropopressure ,hemeroby ,wciornastki ,środowisko miejskie ,antropopresja ,hemerobia ,Environmental technology. Sanitary engineering ,TD1-1066 - Abstract
W latach 2001-2003 prowadzono badania nad wciornastkami (Thysanoptera) w Lublinie (południowo-wschodnia Polska). Celem pracy było poznanie składu gatunkowego tych owadów na wybranych roślinach z rodziny złożonych (Asteraceae), zbieranych z miejsc o różnym stopniu antropopresji w Lublinie. Wyznaczono 15 stanowisk położonych w różnych częściach miasta, które zaliczono do półnaturalnych oraz antropogenicznych. W wyniku badań stwierdzono występowanie 36 gatunków wciornastków. W całym materiale dominowały gatunki Thrips physapus, Thrips trehernei, Thrips validus i Frankliniella intonsa. Największą różnorodnością gatunkową wciornastków charakteryzowały się gatunki roślin: Hieracium umbellatum, Matricaria perforata, Taraxacum officinale, Erigeron strigosus. W wyniku przeprowadzonych badań można stwierdzić, iż środowisko miejskie jest dość bogate pod względem różnorodności gatunkowej wciornastków. Odłowiona liczba gatunków wskazuje na ich tolerancję na umiarkowanie niekorzystne warunki panujące w mieście. Najważniejszym czynnikiem wpływającym na liczbę zebranych gatunków jest bogactwo gatunkowe roślin. Stanowiska o różnym stopniu przekształcenia różniły się zarówno składem gatunkowym, jak i liczebnością stwierdzonych wciornastków.
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- 2013
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135. The effect of accumulation of metals on selected physiological biomarkers in Cochlodina (Cochlodina) laminata (Pulmonata:Clausiliidae) inhabiting urban biocenoses / Wpływ akumulacji metali na wybrane biomarkery fizjologiczne Cochlodina (Cochlodina) laminata (Pulmonata:Clausiliidae) zasiedlających urbicenozy
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Kowalczyk-Pecka Danuta and Czepiel-Mil Katarzyna
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clausiliidae ,cochlodina ,bioindicators ,heavy metals ,enterobacteriaceae ,biowskaźniki ,metale ciężkie ,Environmental technology. Sanitary engineering ,TD1-1066 - Abstract
Wykorzystując powszechnie występujące w całej Europie, niewielkie rozmiarowo ślimaki Cochlodina (Cochlodina) laminata przeprowadzono analizę akumulacji metali w tkankach miękkich oraz w muszlach mięczaków. Porównano trzy lokalizacje wyznaczone w okolicach lubelskich nekropolii i różniących się stopniem antropopresji. Zaliczono przedstawiciela Clausiliidae do użytecznego dla biomonitoringu panelu (zestawu) taksonów Pulmonata obok Arianta, Cepaea, Fruticicola. Stwierdzono makrokoncentracyjne właściwości tkanek miękkich ślimaków dla Zn, Cu oraz Cd w stosunku do wartości oznaczonych w glebie. Mikrokoncentracja natomiast została oznaczona w przypadku Fe, Pb i Cr zarówno w tkankach miękkich, jak i w muszlach. Wykazano różnice fenotypowe bakterii Enterobacteriaceae związanych z układem pokarmowym badanych ślimaków
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- 2013
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136. Generation of miRNA sponge constructs
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Kluiver, Joost, Slezak-Prochazka, Izabella, Smigielska-Czepiel, Katarzyna, Halsema, Nancy, Kroesen, Bart-Jan, and van den Berg, Anke
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- 2012
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137. Osteopenia and osteoporosis among patients with human immunodeficiency virus infection
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Czepiel, Jacek, Biesiada, Grażyna, Mach, Tomasz, and Garlicki, Aleksander
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- 2012
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138. Angiotensin II receptor 1 controls profibrotic Wnt/β-catenin signalling in experimental autoimmune myocarditis
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Urs Eriksson, Przemyslaw Blyszczuk, Maciej Siedlar, Marcin Czepiel, Gabriela Kania, Karolina Tkacz, Agnieszka Jaźwa-Kusior, Ryszard T. Smolenski, Dario Diviani, and Filip Rolski
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CD4-Positive T-Lymphocytes ,0301 basic medicine ,Angiotensin receptor ,Physiology ,Cardiac fibrosis ,Autoimmunity ,030204 cardiovascular system & hematology ,Lymphocyte Activation ,Experimental autoimmune myocarditis ,0302 clinical medicine ,Fibrosis ,Myocytes, Cardiac ,AcademicSubjects/MED00200 ,Wnt Signaling Pathway ,Cells, Cultured ,beta Catenin ,Mice, Knockout ,Mice, Inbred BALB C ,Immunity and Inflammation ,biology ,Chemistry ,Angiotensin II ,Wnt signaling pathway ,Inflammatory cells ,Myocarditis ,Inflammation Mediators ,Cardiology and Cardiovascular Medicine ,Wnt1 Protein ,Receptor, Angiotensin, Type 1 ,Autoimmune Diseases ,Wnt ,03 medical and health sciences ,Physiology (medical) ,Renin–angiotensin system ,medicine ,Animals ,Angiotensin II receptor 1 ,Cell Proliferation ,TGF-β signalling ,Original Articles ,Transforming growth factor beta ,medicine.disease ,Wnt Proteins ,Disease Models, Animal ,030104 developmental biology ,biology.protein ,Cancer research ,Myocardial fibrosis - Abstract
Aims Angiotensin (Ang) II signalling has been suggested to promote cardiac fibrosis in inflammatory heart diseases; however, the underlying mechanisms remain obscure. Using Agtr1a-/- mice with genetic deletion of angiotensin receptor type 1 (ATR1) and the experimental autoimmune myocarditis (EAM) model, we aimed to elucidate the role of Ang II-ATR1 pathway in development of heart-specific autoimmunity and post-inflammatory fibrosis. Methods and results EAM was induced in wild-type (WT) and Agtr1a-/- mice by subcutaneous injections with alpha myosin heavy chain peptide emulsified in complete Freund’s adjuvant. Agtr1a-/- mice developed myocarditis to a similar extent as WT controls at day 21 but showed reduced fibrosis and better systolic function at day 40. Crisscross bone marrow chimaera experiments proved that ATR1 signalling in the bone marrow compartment was critical for cardiac fibrosis. Heart infiltrating, bone-marrow-derived cells produced Ang II, but lack of ATR1 in these cells reduced transforming growth factor beta (TGF-β)-mediated fibrotic responses. At the molecular level, Agtr1a-/- heart-inflammatory cells showed impaired TGF-β-mediated phosphorylation of Smad2 and TAK1. In WT cells, TGF-β induced formation of RhoA-GTP and RhoA-A-kinase anchoring protein-Lbc (AKAP-Lbc) complex. In Agtr1a-/- cells, stabilization of RhoA-GTP and interaction of RhoA with AKAP-Lbc were largely impaired. Furthermore, in contrast to WT cells, Agtr1a-/- cells stimulated with TGF-β failed to activate canonical Wnt pathway indicated by suppressed activity of glycogen synthase kinase-3 (GSK-3)β and nuclear β-catenin translocation and showed reduced expression of Wnts. In line with these in vitro findings, β-catenin was detected in inflammatory regions of hearts of WT, but not Agtr1a-/- mice and expression of canonical Wnt1 and Wnt10b were lower in Agtr1a-/- hearts. Conclusion Ang II-ATR1 signalling is critical for development of post-inflammatory fibrotic remodelling and dilated cardiomyopathy. Our data underpin the importance of Ang II-ATR1 in effective TGF-β downstream signalling response including activation of profibrotic Wnt/β-catenin pathway., Graphical Abstract
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- 2021
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139. T Lymphocyte-Derived Exosomes Transport MEK1/2 and ERK1/2 and Induce NOX4-Dependent Oxidative Stress in Cardiac Microvascular Endothelial Cells
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Rolski, Filip, primary, Czepiel, Marcin, additional, Tkacz, Karolina, additional, Fryt, Katarzyna, additional, Siedlar, Maciej, additional, Kania, Gabriela, additional, and Błyszczuk, Przemysław, additional
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- 2022
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140. Changes in the liver proteome in apoE knockout mice exposed to inhalation of silica nanoparticles indicate mitochondrial damage and impairment of ER stress responses associated with microvesicular steatosis
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Stachyra, Kamila, primary, Kiepura, Anna, additional, Suski, Maciej, additional, Ulatowska-Białas, Magdalena, additional, Kuś, Katarzyna, additional, Wiśniewska, Anna, additional, Czepiel, Klaudia, additional, Majka, Grzegorz, additional, and Olszanecki, Rafał, additional
- Published
- 2022
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141. Aesthetic and physiological effects of naturalistic multimodal music listening
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Czepiel, Anna, primary, Fink, Lauren K., additional, Seibert, Christoph, additional, Scharinger, Mathias, additional, and Kotz, Sonja A., additional
- Published
- 2022
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142. The association of the IL-1ß-31 polymorphism and the development of neuroinfections
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Grażyna Biesiada, Jacek Czepiel, Anna Piątek, Malwina Birczyńska, Justyna Żurańska, Paweł Wołkow, William Perucki, Michał Jędrychowski, and Aleskander Garlicki
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polymorphisms of genes ,neuroinfection ,IL-1ß ,TNF-? ,IL-8 ,Medicine - Abstract
Introduction. Inflammation of the meninges can have various clinical courses, from mild, self-limiting in some viral neuroinfections to severe, sometimes ending in death. The pro-inflammatory cascade and defects in the inhibitors of the inflammatory response play an important prognostic role. Single nucleotide polymorphisms (SNPs) of the genes encoding cytokines, influence the severity of the inflammatory response. Aim. The aim of this study was to evaluate the effect of selected polymorphisms of proinflammatory cytokines IL-1ß, TNF-? and IL-8 on the development of neuroinfections. Material and Methods. We evaluated the laboratory results of 30 patients treated for bacterial and viral meningitis and compared those to 30 healthy volunteers. The following 4 variants were analyzed for occurrence of genetic polymorphism in patients with meningitis versus the control group: IL-1ß 3953, IL-1ß -31, TNF-? -308, and IL-8 781. Then, we assessed the association between these genetic polymorphisms and the inflammatory response during the course of meningitis. Results and Conclusions. We observed that polymorphism of the IL-1ß-31 significantly differs between patients and healthy subjects, the IL-1ß -31AA polymorphism existed only in healthy individuals (p
- Published
- 2016
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143. HOW PURE IS PURE ALEXIA? A NEUROPSYCHOLOGICAL ANALYSIS OF A CASE SERIES OF PATIENTS WITH ALEXIA DUE TO LEFT HEMISPHERIC STROKES
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Aleksandra J. Zielińska, Marcin Leśniak, Wojciech Czepiel, and Joanna Seniów
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medicine.medical_specialty ,Neuropsychology and Physiological Psychology ,Neuropsychology ,Dyslexia ,medicine ,Audiology ,medicine.disease ,Psychology ,Pure alexia ,Applied Psychology - Abstract
The aim of this study was to analyze a case series with acquired alexia after stroke within the posterior areas of the left hemisphere, in the context of the current criteria for pure alexia and their relevance to the set of symptoms observable in clinical practice. Seven patients with ischemic strokes and an initial diagnosis of pure alexia were enrolled for detailed analysis. The evaluation consisted of neuropsychological assessment in the form of standardized tests and non-standardized reading tasks, while oculomotor activity during reading was measured. Language functions, visual object and space perception, verbal and nonverbal memory, and visuospatial constructional ability were among the domains assessed. In five of the participants, pure alexia was recognized based on sig- nificant and specific discrepancies between test scores, indicating primary abnormalities in the visual processing of letter strings as a basic mechanism of the disorder. In most of the patients, coexisting cognitive deficits were revealed; however, these were dispropor- tionately milder and less functionally significant than reading disturbances. Pure alexia is a relatively rare disorder after a stroke, but it considerably affects the quality of everyday independent functioning. Its clinical characteristics in practice rarely meet all the criteria proposed in the subject literature. The differential diagnosis of this form of alexia and other reading disorders requires detailed clinical analysis.
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- 2020
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144. Different MAF translocations confer similar prognosis in newly diagnosed multiple myeloma patients
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Krzysztof Jamroziak, Artur Jurczyszyn, Chor Sang Chim, Monika Długosz-Danecka, Deepu Madduri, Julia Kelman, Max Bittrich, Michel Delforge, Klaus Martin Kortüm, Gabor Mikala, Ariel Kleman, Jorge J. Castillo, Maria-Victoria Mateos, Adam J. Olszewski, Saurabh Chhabra, Pawel Robak, Lidia Usnarska-Zubkiewicz, Anna Waszczuk-Gajda, Iwona Hus, Sarah Goldman-Mazur, David Jayabalan, Julio Davila Valls, Irit Avivi, Rebecca Silbermann, Norbert Grząśko, Stuart L. Goldberg, David H. Vesole, Yael C Cohen, Ruben Niesvizky, Piotr Mazur, Anna Suska, Verónica González-Calle, Laura Rosiñol, Alessandro Gozzetti, Łukasz Szukalski, Jacek Czepiel, Jakub Radocha, Parameswaran Hari, Daniel Coriu, Izabela Kozłowska, Aimee Chappell, Peter Barth, and Massimo Gentile
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Oncology ,Cancer Research ,medicine.medical_specialty ,Translocation ,Chromosomal translocation ,Newly diagnosed ,Transplantation, Autologous ,survival ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Multiple myeloma ,Retrospective Studies ,16) ,MAF ,myeloma ,t(14 ,20) ,business.industry ,Hematopoietic Stem Cell Transplantation ,Small sample ,Hematology ,Prognosis ,medicine.disease ,Treatment Outcome ,030220 oncology & carcinogenesis ,Multiple Myeloma ,business ,Large group ,030215 immunology - Abstract
The MAF translocations, t(14;16) and t(14;20), are considered as adverse prognostic factors based on few studies with small sample sizes. We report on their prognostic impact in a large group of 254 patients - 223 (87.8%) with t(14;16) and 31 (12.2%) with t(14;20). There were no intergroup differences in survival estimates. Median progression-free survival was 16.6 months for t(14;16) and 24.9 months for t(14;20) (
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- 2020
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145. ‘El canto y lira mía’: The Horatian authorial persona in the work of Fray Luis de León
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MARIA CZEPIEL
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Linguistics and Language ,Literature and Literary Theory ,Language and Linguistics - Abstract
In this study I discuss the generic implications of Fray Luis’s adoption of the Horatian authorial persona. Firstly, I interpret Ode I as a statement of his poetic programme. Next, I argue that in Ode XXII Fray Luis navigates lyric’s apparent rejection of epic themes by modelling his portrayal of Pedro Portocarrero on Horace’s relationship with Maecenas. I then discuss how other elevated poems are compatible with the lyric persona through their affiliation with the hymn form and particularly with Pindar’s lyric. Critics often comment that Fray Luis avoids amatory themes; while this is true in his original poetry, I argue that in his translations of Horace and in his use of Classical allusion in the Latin commentary In Canticum Canticorum, the lyric persona gives him both the licence to treat amatory themes and the ability to distance himself from them through Horatian humour.
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- 2022
146. Two newly discovered poems by Garcilaso de la Vega
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Maria Czepiel
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Cultural Studies ,Literature and Literary Theory - Abstract
The Latin poetry of Garcilaso de la Vega was highly regarded by his contemporaries. However, until now, only three of his Latin lyric odes have been extant, and these are often disparaged by modern critics. In this study, I present two newly discovered poems by Garcilaso: the lyric-ode addressed to Bembo which the latter refers to in his correspondence, and another lyric-ode addressed to the poet Johann Alexander Brassicanus. I also present new critical editions of the three extant poems in the light of new witnesses from the same source. I argue that the poems constitute sophisticated meditations on the purpose of encomiastic literature and the nature of lyric poetry. In this way I aim to provide a better understanding of Garcilaso’s Latin odes and restore his reputation as a consummate Latin poet.
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- 2022
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147. Food as Medicine for Obesity Treatment and Management
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Veronica R. Johnson, Tiffani Bell Washington, Shradha Chhabria, Emily Hsu-Chi Wang, Kathryn Czepiel, Karen J. Campoverde Reyes, and Fatima Cody Stanford
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Pharmacology ,Adult ,Pediatric Obesity ,Adolescent ,Weight Loss ,Humans ,Nutritional Status ,Pharmacology (medical) ,Child ,Life Style ,Article - Abstract
PURPOSE: Nutrition is an important lifestyle modification used in the treatment of obesity. The purpose of this review is to highlight different dietary interventions used to promote weight loss in both adults and children. METHODS: A search using PubMed was performed for articles on topics related to nutrition and management and/or treatment of obesity in adults adolescents and children. The literature was reviewed and pertinent sources were used for this narrative review. DISCUSSION: There are many effective nutrition interventions used to treat obesity, including altering macronutrient composition, implementing different dietary patterns, and changing meal timing. Although these interventions can induce weight loss in adults, management of obesity in children is more difficult given their varied nutrition needs in growth and development. The use of food as medicine in obesity treatment is individualized based on patient’s age, food preference, and concurrent medical conditions. IMPLICATIONS: Given the multifactorial etiology of obesity, treatment requires multidisciplinary care beyond nutrition intervention.
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- 2022
148. They didn’t cover this in lecture: The formation and dissolution of the patient-provider relationship
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Czepiel, Kathryn S.
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- 2018
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149. Ejecutor de búsquedas del tesoro con realidad aumentada
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Gómez Martín, Pedro Pablo, González Calero, Pedro Antonio, Osés Sánchez, Leire, De Lucas Gómez, Adrián, Czepiel, David, Molina Cumba, William, Gómez Martín, Pedro Pablo, González Calero, Pedro Antonio, Osés Sánchez, Leire, De Lucas Gómez, Adrián, Czepiel, David, and Molina Cumba, William
- Abstract
Las búsquedas del tesoro y las yincanas son una serie de juegos tradicionales que consisten en tratar de resolver una serie de retos y pruebas con el objetivo de ganar algún tipo de premio o recompensa. Pueden ser jugados de forma individual o en grupos y pueden tener un planteamiento más competitivo o casual. La idea del TFG es crear un motor y una herramienta web que sirva para poder generar este tipo de juegos con la premisa de que el usuario no necesita tener conocimiento de programación alguno. Estas aplicaciones estarán formadas por fases de diferentes tipos y en diversas cantidades según las necesidades del creador de la aventura para adaptarse mejor al entorno donde va a ser utilizado y el objetivo que se quiere conseguir. Para generar las aventuras los usuarios deben hacer uso de una herramienta web disponible en un servidor de la UCM donde pueden configurar desde el nombre de la aventura que vayamos a crear, a todas y cada una de las diferentes fases disponibles y luego permitir descargarnos el proyecto para generar el instalador para dispositivos Android., Treasure hunts and gymkhanas are a type of traditional games that consist in trying to solve a series of challenges and tests with the premise of winning some kind of prize or reward. They can be played individually or in groups and they can have a competitive or casual approach. The idea of the TFG is to create an engine and a web tool that is used to generate and play this type of games with the premise that the user does not need to have any knowledge of programming to make use of it. These applications will be made up of phases of different types and in various amounts according to the needs of the creator of the adventure to better adapt it to the environment where it will be used and the objective trying to be achieved. In order to create these games users will use a web tool available at a UCM server where they can configure from the name of the adventure that they are going to create, each and every one of the different phases available and then allow them to download the project to generate the installer to use it in Android devices.
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- 2022
150. This title is unavailable for guests, please login to see more information.
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Czepiel, Marcin, Diviani, Dario, Jaźwa-Kusior, Agnieszka, Tkacz, Karolina, Rolski, Filip, Smolenski, Ryszard T, Siedlar, Maciej, Eriksson, Urs, Kania, Gabriela, Błyszczuk, Przemysław, Czepiel, Marcin, Diviani, Dario, Jaźwa-Kusior, Agnieszka, Tkacz, Karolina, Rolski, Filip, Smolenski, Ryszard T, Siedlar, Maciej, Eriksson, Urs, Kania, Gabriela, and Błyszczuk, Przemysław
- Published
- 2022
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