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113. Therapeutic Potential of Caffeic Acid Phenethyl Ester (CAPE) in Diabetes

Author

Pittalà, Valeria, Salerno, Loredana, Romeo, Giuseppe, Acquaviva, Rosaria, Di Giacomo, Claudia, and Sorrenti, Valeria

Abstract

Diabetes mellitus is a complex metabolic disease characterized by high blood sugar levels. Different pathogenic processes are involved in the etiology of the disease. Indeed, chronic diabetes hyperglycemia is often associated with severe long-term complications including cardiovascular symptoms, retinopathy, nephropathy, and neuropathy. Although the precise molecular mechanisms underlying diabetes are not yet clear, it is widely accepted that increased levels of oxidative stress are involved in the onset, development and progression of diabetes and its related complications. In this regard, the use of natural antioxidant polyphenols, able to control free radical production, to increase intracellular antioxidant defense and to prevent the onset of oxidative stress, can be of high interest. Caffeic acid phenethyl ester (CAPE), a natural polyphenolic substance, is one of the main components of propolis. Due to its multifaceted biological activities, including antioxidant, antimicrobial, anti-inflammatory, antitumor, and immunomodulatory effects, CAPE has received great attention during the last few decades. In the present paper the therapeutic potential of CAPE in diabetes is extensively reviewed.

Published
2018
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149. Caffeic Acid Phenethyl Ester Restores Adipocyte Gene Profile Expression Following Lipopolysaccharide Treatment

Author

Barbagallo, Ignazio, Li Volti, Giovanni, Sorrenti, Valeria, Di Giacomo, Claudia, Acquaviva, Rosaria, Raffaele, Marco, Galvano, Fabio, and Vanella, Luca

Abstract

Background: Obesity alters endocrine and metabolic function of the adipose tissue leading to an increased release of fatty acids, adipokynes and pro-inflammatory molecules which in turn lead to complications related to the onset of metabolic syndrome. Methods: To this regard, natural antioxidants have been found to have anti-inflammatory and protective action in cardiovascular diseases, diabetes mellitus and obesity. Caffeic acid phenethyl ester (CAPE) is synthesized in a variety of plants and is one of the main components of propolis. CAPE inhibits oxidative stress and showed beneficial effects under various experimental conditions. Aims: The aim of the study was to evaluate the effect of CAPE on adipocyte function after an inflammatory stimulus with lipopolysaccharide (LPS) (1 ng/ml for 6h). Results: Our data showed that LPS caused an increased expression of proinflammatory interleukin IL-6 and a lipolytic effect on the adipocytes. CAPE treatment inhibited LPS effects through a significant decrease of IL-6 and a concomitant increase of peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT/Enhancer Binding Protein alpha (CEBPα), fatty acid synthase (FAS), fatty acid binding protein 4 (FABP4), diacylglycerol O-acyltransferase 1 (DGAT1) and transcription factor sterol regulatory element binding protein-1c (SREBP-1c). Moreover, the increased levels of adiponectin, heme oxygenase-1, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), peroxisome proliferator- activated receptor alpha (PPARα) and Sirtuin-1 suggest that CAPE administration restores adipocyte function following inflammation. Conclusion: In conclusion, the use of this metabolite such as a food supplement may represent a possible strategy for the treatment of conditions related to metabolic syndrome.

Published
2017

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