101. Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3)
- Author
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Seong Eon Ryu, Byoung-Mog Kwon, Dong Cho Han, Kwang-Hee Son, Dae Gwin Jeong, Sung‐Kyu Choi, Nam-In Baek, Hyun-Mi Oh, Nack-Do Sung, and Su-Kyung Lee
- Subjects
Flavonoids ,Biological Products ,Biflavonoids ,Molecular Structure ,biology ,Organic Chemistry ,Phosphatase ,Plant Science ,Protein tyrosine phosphatase ,biology.organism_classification ,Antineoplastic Agents, Phytogenic ,Biochemistry ,Liver regeneration ,Neoplasm Proteins ,Analytical Chemistry ,Sciadopitysin ,Ic50 values ,Humans ,Protein Tyrosine Phosphatases ,Taxus ,Taxus cuspidata - Abstract
Two biflavonoids, ginkgetin (1) and sciadopitysin (2), were isolated from the MeOH extract of the young branches of Taxus cuspidata, which inhibited phosphatase of regenerating liver-3 (PRL-3) with IC50 values of 25.8 and 46.2 microM, respectively. This is the first report on PRL-3 inhibitors, isolated from natural sources.
- Published
- 2006