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101. Curcumin delivery by modified biosourced carbon-based nanoparticles

Author

Danafar, Hossein, primary, Salehiabar, Marziyeh, additional, Barsbay, Murat, additional, Rahimi, Hossein, additional, Ghaffarlou, Mohammadreza, additional, Arbabi Zaboli, Kasra, additional, Faghfoori, Mohammad Hasan, additional, Kaboli, Saeed, additional, Nosrati, Hamed, additional, and Faghfoori, Zeinab, additional

Published
2022
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106. Bovine serum albumin-mediated synthesis and quorum sensing inhibitory properties of Ag–Ag2S nanoparticles.

Author

Ghaffarlou, Mohammadreza, İlk, Sedef, Rahimi, Hossein, Danafar, Hossein, Barsbay, Murat, and Sharafi, Ali

Abstract

Aim: Quorum sensing (QS) is a density-dependent chemical process of cell-to-cell communication in which certain signals are activated, leading to the coordination of pathogenic behaviors and the regulation of virulence in bacteria. Inhibition of QS can prevent biofilm formation and reduce virulence behaviors of bacteria. Herein, bovine serum albumin (BSA)-coated silver nanoparticles (NPs) (Ag–Ag2S@BSA NPs) were synthesized and studied as an anti-QS agent. Materials & methods: Ag–Ag2S NPs prepared through a BSA-mediated biomineralization process under ambient aqueous conditions and their physicochemical properties were characterized. The anti-QS activity of the resulting BSA-coated NPs (Ag–Ag2S@BSA NPs) was investigated for the first time. Results & conclusion: The result confirmed the potential of Ag–Ag2S@BSA NPs as novel and useful therapeutic tools for antibacterial purposes. The overuse of antibiotics has caused the development of drug-resistant strains of bacteria. Nowadays, drug resistance is one of the main challenges in the treatment and prevention of microbial diseases. In general, many bacterial species communicate with each other through a population-dependent mechanism called quorum sensing to control their physiological activities. Therefore, inhibiting the quorum sensing mechanism is an attractive alternative to antibiotics and also reduces the risk of drug resistance, and this can be achieved by nanoparticles (NPs). Among these nanostructures, Ag NPs have received particular attention due to their antimicrobial, antibiofilm, anticancer and antioxidant properties. Herein, we report a method that applies a BSA-guided green and one-pot approach for achieving Ag–Ag2S NPs as potential antibacterial agents. [ABSTRACT FROM AUTHOR]

Published
2022
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107. Synthesis of Carbon Nanosheets from Onion Peels for Removing Methylene Blue from Aqueous Environments.

Author

Hariri, Negar, Danafar, Hossein, Mohammadi, Ali, and Fazli, Mehran Mohammadian

Subjects
*ONIONS, *CARBON nanotubes, *METHYLENE blue, *SORBENTS, *SOLID waste management, *PYROLYSIS
Abstract

Background: Nowadays, colored water and, remarkably, wastewaters from dyeing industries are one of the most significant sources of toxic compounds in the environment. On the other hand, waste management and reduction are the most main obstacles governments encounter. Therefore, this study aimed to use waste materials to remove contaminants. Method: First, we pyrolyzed onion peels, added distilled water, and then sonicated the solution. AFM (Atomic force microscopy) analysis determined the characteristics of produced carbon nanosheets. Batch experiments on the synthesized carbon nanosheets implemented adsorption studies. The effects of adsorbent dose, pH, dye concentration, and temperature were also evaluated. Results: The isotherm assessments indicated that the data significantly matches the Langmuir model; moreover, the kinetic modeling results showed that the experimental data perfectly matched the pseudo-second-order kinetic model. Conclusion: Synthesized carbon nanosheets from onion peel as a low-cost adsorbent with good properties; not only are eco-friendly materials that can significantly reduce solid waste generation, but they are efficient adsorbents for methylene blue removal from aquatic solution. [ABSTRACT FROM AUTHOR]

Published
2022
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109. CuFe2O4decorated with BSA as a potential nanoradioenhancer for enhanced X-ray radiation therapy of brain tumor

Author

Yaray, Kadir, Rashidzadeh, Hamid, Mozafari, Faezeh, Rezaeejam, Hamed, Moghaddam, Zhaleh Karimi, Ertas, Yavuz Nuri, and Danafar, Hossein

Abstract

Glioblastoma (GBM) is a type of the central nervous system malignancy and considered as the most lethal and aggressive primary brain tumor. Adjuvant radiotherapy (RT) along with temozolomide (TMZ) is considered as the standard treatment regimen for GBM. However, implementation of RT in tumor suppression is frequently accompanied by several side effects. Additionally, dose limitation and radioresistance are other major drawbacks associated with radiation therapy. To this end, nanoradioenhancer/or nanoradiosensitizer based on high-Z metallic elements has emerged as a powerful treatment modality in GBM therapy. In this study, CuFe2O4decorated with BSA nanoplatforms (CuFe2O4@BSA) was fabricated to improve the theraputics potential of RT through sensitizing the U-87 GBM cells to X-ray radiation. The characterization techniques such as FTIR, XRD, EDS and UV–Vis spectroscopy confirmed successful fabrication of CuFe2O4@BSA radioenhancer, while also TEM images indicated the prepared nanoradiosensitizers are uniform, homogenous, and spherical with an average size of about 5 nm. In vitro hemocompatibility and cytocompatibility of developed CuFe2O4@BSA nanoradiosensitizers were also investigated by hemolysis and MTT assay, respectively. The merits of CuFe2O4@BSA nanoplatforms in sensitizing the U-87 cells to the ionizing radiation were also exploited using intracellular ROS generation and MTT assay. It was found that CuFe2O4@BSA nanoradiosensitizers did not cause any deleterious effects on primary human umbilical vein endothelial cells (HUVEC) of which the cell viability of all treated group was beyond 95%, endorsing the cytocompatibility and safety of these nanoplatforms for further assessment. Hemolysis assay also confirms the biosafety of CuFe2O4@BSA nanoradiosensitizers, exhibiting no significant toxicity against human red blood cells in which the degree of hemolysis was less than 4%. In vitro cancer radiotherapy also demonstrated that the cell viability of U-87 GBM was considerably decreased once co-modality of X-ray and CuFe2O4@BSA nanoradiosensitizers were used simultaneously. Radiosensitizing ability of these nanoparticles was also proved by intracellular ROS generation, of which implementation of CuFe2O4@BSA nanoradiosensitizers upon X-ray irradiation resulted in superior ROS production. Overall, these findings provide vital evidence for applicability of prepared CuFe2O4@BSA nanoradiosensitizers in killing the primary brain tumor cells specifically GBM.

Published
2023
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111. Evaluation of PLGA nanoparticles containing outer membrane proteins of Acinetobacter baumannii bacterium in stimulating the immune system in mice.

Author

Gholizadeh, Afshin, Shapoury, Reza, Pakzad, Parviz, Mahdavi, Mehdi, and Danafar, Hossein

Subjects
ACINETOBACTER baumannii, MEMBRANE proteins, IMMUNE system, SURFACE charges, NANOPARTICLES, MICE
Abstract

Background and purpose: Acinetobacter baumannii (A. baumannii) is known as a pathogen with antibiotic resistance, causing respiratory infections. PLGA has been approved for use in vaccines as well as drug delivery. This study was performed to evaluate PLGA nanoparticles containing the outer membrane proteins (OMPs) of A. baumannii in stimulating the mice's immune system and improving pneumonia. Experimental approach: Double emulsion solvent evaporation technique was used. The properties of the obtained nanospheres were determined using a zetasizer, FTIR, and AFM devices. Nanoparticles were administered to mice BALB/c by applying the intramuscular route. ELISA was used to measure the amounts of immunoglobulins produced; also, an opsonophagocytic killing assay was used to measure the effectiveness of immunoglobulins. Immunized mice were then challenged with live A. baumannii through the lungs; their internal organs were also removed for bacteriological studies. Findings/Results: The prepared particles were 550 nm in diameter with a negative surface charge. The production of the OMPs specific IgG was much higher in the group receiving nanoparticles containing antigen as compared to those getting pure antigen. The immunoglobulins produced against nanoparticles were superior to those developed against pure antigens. Mice that received the new nanovaccine were more resistant to pneumonia caused by this bacterium than those that received pure antigen. Conclusion and implication: Overall, it can be said that PLGA nanoparticles could deliver their internal antigens (OMPs) well to the immune system of mice and stimulate humoral immunity in these animals, thus protecting them against pneumonia caused by A. baumannii. [ABSTRACT FROM AUTHOR]

Published
2022
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113. Nanotechnology against the novel coronavirus (severe acute respiratory syndrome coronavirus 2): diagnosis, treatment, therapy and future perspectives

Author

Rashidzadeh, Hamid, primary, Danafar, Hossein, additional, Rahimi, Hossein, additional, Mozafari, Faezeh, additional, Salehiabar, Marziyeh, additional, Rahmati, Mohammad Amin, additional, Rahamooz-Haghighi, Samaneh, additional, Mousazadeh, Navid, additional, Mohammadi, Ali, additional, Ertas, Yavuz Nuri, additional, Ramazani, Ali, additional, Huseynova, Irada, additional, Khalilov, Rovshan, additional, Davaran, Soodabeh, additional, Webster, Thomas J, additional, Kavetskyy, Taras, additional, Eftekhari, Aziz, additional, Nosrati, Hamed, additional, and Mirsaeidi, Mehdi, additional

Published
2021
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115. CRISPR Systems for COVID-19 Diagnosis

Author

Rahimi, Hossein, primary, Salehiabar, Marziyeh, additional, Barsbay, Murat, additional, Ghaffarlou, Mohammadreza, additional, Kavetskyy, Taras, additional, Sharafi, Ali, additional, Davaran, Soodabeh, additional, Chauhan, Subhash C., additional, Danafar, Hossein, additional, Kaboli, Saeed, additional, Nosrati, Hamed, additional, Yallapu, Murali M., additional, and Conde, João, additional

Published
2021
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116. Iron oxide and gold bimetallic radiosensitizers for synchronous tumor chemoradiation therapy in 4T1 breast cancer murine model

Author

Nosrati, Hamed, primary, Baghdadchi, Yasamin, additional, Abbasi, Reza, additional, Barsbay, Murat, additional, Ghaffarlou, Mohammadreza, additional, Abhari, Fatemeh, additional, Mohammadi, Ali, additional, Kavetskyy, Taras, additional, Bochani, Shayesteh, additional, Rezaeejam, Hamed, additional, Davaran, Soodabeh, additional, and Danafar, Hossein, additional

Published
2021
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117. Targeted drug delivery via folate decorated nanocarriers based on linear polymer for treatment of breast cancer.

Author

Zamani, Mostafa, Aghajanzadeh, Mozhgan, Sharafi, Ali, Rostamizadeh, Kobra, and Danafar, Hossein

Subjects
TARGETED drug delivery, POLYMERSOMES, LINEAR polymers, BREAST cancer, NANOCARRIERS, DRUG delivery systems, ETHYLENE glycol, FOLIC acid
Abstract

In this project, a biocompatible block copolymer including poly ethylene glycol and poly caprolactone was synthesized using ring-opening reaction. Then, the copolymer was conjugated to folic acid using lysine as a linker. Also, curcumin (CUR) was used as a therapeutic anticancer agent. Nanoprecipitation method was used to prepare CUR-loaded polymeric micelles. Different methods including Fourier-transform infrared spectroscopy, transmission electron microscopy (TEM), and dynamic light scattering (DLS) were used to characterize the prepared nanocarriers (NCs). MTT assay and hemolysis assay were used to evaluate in vitro anticancer efficiency and biocompatibility of the prepared NCs, respectively. The results proved efficiency of NCs as a drug delivery system (DDS) in various aspects such as physicochemical properties and biocompatibility. Also, in vivo results showed that NCs did not show any severe weight loss and side effects on mice, and the anti-cancer study results of the CUR-loaded NCs proved that the conjugation of folic acid on the surface of NCs as a targeting agent could increase the therapeutic efficacy of CUR. [ABSTRACT FROM AUTHOR]

Published
2022
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128. Improved synergic therapeutic effects of chemoradiation therapy with the aid of a co-drug-loaded nano-radiosensitizer under conventional-dose X-ray irradiation

Author

Nosrati, Hamed, primary, Charmi, Jalil, additional, Abhari, Fatemeh, additional, Attari, Elahe, additional, Bochani, Shayesteh, additional, Johari, Behrooz, additional, Rezaeejam, Hamed, additional, Kheiri Manjili, Hamidreza, additional, Davaran, Soodabeh, additional, and Danafar, Hossein, additional

Published
2020
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131. Novel and promising approaches in COVID-19 treatment.

Author

ASEFY, Zahra, RASHIDZADEH, Hamid, MOHAMMADI, Ali, CHAREHSAZ, Mohammad, SİPAHİ, Hande, AYDIN, Ahmet, HELVACIOĞLU, Sinem, KHALILOV, Rovshan, ZHDANOV, Renad Ibragimovich, DANAFAR, Hossein, HASANZADEH, Amir, and EFTEKHARI, Aziz

Subjects
COVID-19 treatment, SARS-CoV-2, COVID-19, MIDDLE East respiratory syndrome, EXTRACELLULAR vesicles, KILLER cells, COMMUNICABLE diseases
Abstract

Novel coronavirus or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes severe respiratory infectious disease, known as coronavirus disease-19 (COVID-19). Over the past few months, a considerable rise in the incidence rate and prevalence of COVID-19 infection have been witnessed. Considering the high disease burden and rapid spread of the COVID-19 and no effective treatment is currently existing, stem cells, engineered nanobiomaterials, natural killer cells based therapy, RNA metabolites and extracellular vesicles are promising alternatives to tackle devastating epidemic. This review spotlights the applications and potential of above-mentioned methods in the treatment of COVID-19. [ABSTRACT FROM AUTHOR]

Published
2021
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132. Niosome: A Promising Nanocarrier for Natural Drug Delivery through Blood-Brain Barrier

Author

Gharbavi, Mahmoud, Amani, Jafar, Kheiri-Manjili, Hamidreza, Danafar, Hossein, and Sharafi, Ali

Subjects
Article Subject
Abstract

Niosomes (the nonionic surfactant vesicles), considered as novel drug delivery systems, can improve the solubility and stability of natural pharmaceutical molecules. They are established to provide targeting and controlled release of natural pharmaceutical compounds. Many factors can influence on niosome construction such as the preparation method, type and amount of surfactant, drug entrapment, temperature of lipids hydration, and the packing factor. The present review discusses about the most important features of niosomes such as their diverse structures, the different preparation approaches, characterization techniques, factors that affect their stability, their use by various routes of administration, their therapeutic applications in comparison with natural drugs, and specially the brain targeting with niosomes-ligand conjugation. It also provides recent data about the various types of ligand agents which make available active targeting drug delivery to the central neuron system. This system has an optimistic upcoming in pharmaceutical uses, mostly with the improving availability of innovative schemes to overcome blood-brain barrier and targeting the niosomes to the brain.

Published
2018
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143. Glutathione (GSH) Peptide Conjugated Magnetic Nanoparticles As Blood–Brain Barrier Shuttle for MRI-Monitored Brain Delivery of Paclitaxel

Author

Nosrati, Hamed, primary, Tarantash, Mahsa, additional, Bochani, Shayesteh, additional, Charmi, Jalil, additional, Bagheri, Zahra, additional, Fridoni, Mohammadjavad, additional, Abdollahifar, Mohammad-Amin, additional, Davaran, Soodabeh, additional, Danafar, Hossein, additional, and Kheiri Manjili, Hamidreza, additional

Published
2019
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