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563 results on '"Di Filippo S"'

102. 'Pulse oral' versus intravenous calcitriol therapy in chronic hemodialysis patients. A prospective and randomized study

Author

Bacchini G, Fabrizi F, Pontoriero G, Daniele Marcelli, Di Filippo S, and Locatelli F

Subjects
Male, Administration, Oral, Middle Aged, Alkaline Phosphatase, Phosphates, Calcitriol, Parathyroid Hormone, Renal Dialysis, Injections, Intravenous, Hypercalcemia, Humans, Calcium, Female, Hyperparathyroidism, Secondary, Prospective Studies
Abstract

The aim of this prospective and randomized study was to compare the efficacy, side effects, and costs of 'pulse oral' versus intravenous calcitriol in the treatment of secondary hyperparathyroidism in hemodialysis (HD) patients. A total of 20 patients were randomized to receive over a 4-month period pulse orally administered calcitriol (pulse oral group; n = 10) or intravenous calcitriol (intravenous group; n = 10). All patients used standard dialysate calcium (1.75 mmol/l) throughout the study period. In accordance with the study design calcium dialysate concentrations were reduced when this was necessary to avoid hypercalcemic crises. The patients were stratified into two subgroups according to their initial serum PTH levels: patients with mild or moderate degree of hyperparathyroidism (17 patients) and patients with severe hyperparathyroidism (3 patients). Intravenous and pulse oral cacitriol did not significantly reduce serum PTH concentrations in patients with severe hyperparathyroidism (1,157 +/- 156 vs. 807 +/- 228 pg/ml [corrected], p = 0.09). Intermittent calcitriol, administered by intravenous or oral route, significantly reduced serum PTH levels (326 +/- 119 vs. 109 +/- 79 pg/ml [corrected], p = 0.0001) in patients with mild or moderate hyperparathyroidism. In patients with mild or moderate hyperparathyroidism, intravenous calcitriol significantly reduced PTH concentrations at the end of the 1st month, before the increase of serum ionized calcium levels, whereas 'pulse oral' calcitriol significantly suppressed parathyroid activity at the end of the 2nd month. Calcium dialysate concentration was reduced in 9 out of 10 (90%) patients of the pulse oral group and in all patients (10/10) of intravenous group. The incidence of hypercalcemic crises was 24% (39/160) in the pulse oral group and 14% (27/160) in the intravenous group. Analysis of costs showed that intravenous calcitriol was more expensive compared to pulse oral calcitriol. These data indicate that intermittent intensive calcitriol therapy, regardless of the route of administration, is effective in suppressing parathyroid activity in HD patients with mild or moderate hyperparathyroidism. In contrast, intermittent calcitriol therapy has a limited ability to achieve sustained serum PTH reductions in HD patients with severe hyperparathyroidism. Intravenous calcitriol was more expensive than pulse oral calcitriol, and we recommend the use of pulse oral calcitriol in HD patients with mild or moderate secondary hyperparathyroidism.

Published
1997

105. Effect of a plasma sodium biofeedback system applied to HFR on the intradialytic cardiovascular stability. Results from a randomized controlled study

Author

Locatelli, F., primary, Stefoni, S., additional, Petitclerc, T., additional, Coli, L., additional, Di Filippo, S., additional, Andrulli, S., additional, Fumeron, C., additional, Frasca, G. M., additional, Sagripanti, S., additional, Savoldi, S., additional, Serra, A., additional, Stallone, C., additional, Aucella, F., additional, Gesuete, A., additional, Scarlatella, A., additional, Quarello, F., additional, Mesiano, P., additional, Ahrenholz, P., additional, Winkler, R., additional, Mandart, L., additional, Fort, J., additional, Tielemans, C., additional, and Navino, C., additional

Published
2012
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106. Monitoring sodium removal and delivered dialysis by conductivity

Author

Francesco Locatelli, Simeone Andrulli, Giuseppe Pontoriero, Celestina Manzoni, M Corti, and Di Filippo S

Subjects
medicine.medical_specialty, Sodium, 030232 urology & nephrology, Biomedical Engineering, Medicine (miscellaneous), chemistry.chemical_element, Bioengineering, 030204 cardiovascular system & hematology, Conductivity, Biomaterials, 03 medical and health sciences, 0302 clinical medicine, Body Water, Renal Dialysis, medicine, Humans, Urea, Intensive care medicine, Urea clearance, Chromatography, Chemistry, Plasma water, Electric Conductivity, General Medicine, Bicarbonates, Blood Component Removal, Dialysis (biochemistry), Mathematics
Abstract

As cardiovascular stability and the delivery of the prescribed dialysis “dose” seem to be the main factors in determining the morbidity and mortality of hemodialyzer patients today, it is of paramount importance to match hydro-sodium removal with interdialytic load and to verify the delivered dialysis at each session. A specially designed Biofeedback Module (BM - COT Hospal) allows the automatic determination of plasma water conductivity and effective ionic dialysance with no need for blood samples. Using BM, we evaluated the validity of “conductivity kinetic modelling” (CKM) and the possibility that this may substitute “sodium kinetic modelling”. Moreover, we evaluated the “in vivo” relationship between ionic dialysance and effective urea clearance. Our results demonstrate that: 1) CKM makes it possible to obtain programmed end-dialysis plasma water conductivity with an error of less than ± 0.14 mS/cm, roughly equivalent to a sodium concentration of ± 1.4 mEq/L. 2). Ionic dialysance and effective urea clearance are not equivalent but, as the interrelationship between these is known, the BM allows the routine monitoring of delivered dialysis.

Published
1995

110. TYRGEONET: campagna GPS 1992

Author

Achilli, Vladimiro, Anzidei, M., Baldi, P., Artese, G., Banni, A., Belardinelli, M. E., Bonini, C., Briole, P., Campolo, F., Capone, G., Capra, A., Casula, G., Crespi, M., DI FILIPPO, S., Giovani, L., Guerra, I., Marchesini, C., Marchetti, M., Marsan, P., Mattone, M., Marsella, M., Moretti, A., Poga, K., Poggi, M., Riguzzi, F., Salemi, G., Stoppini, A., Surace, L., Tertulliani, A., Vecchi, M., Vespe, F., and Vettore, Antonio

Published
1993

112. A prospective clinical study for molecular intra-operative detection of lymph node metastasis in breast cancer patients by one step nucleic acid amplification (OSNA) in comparison to intensive histological investigation

Author

Di Filippo, F., primary, Mottolese, M., additional, Botti, C., additional, Marandino, F., additional, Psaila, A., additional, Perri, P., additional, Di Filippo, S., additional, Pasqualoni, R., additional, Ferranti, F., additional, and Buglioni, S., additional

Published
2009
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115. SHARK-NIR on its way to LBT.

Author

Marafatto, L., Carolo, E., Umbriaco, G., Bergomi, M., Greggio, D., Laudisio, F., Lessio, L., Montoya, M., Radhakrishnan, K., Ricci, D., Vassallo, D., Dima, M., Di Filippo, S., Don, K. W. W., Viotto, V., and Farinato, J.

Published
2022
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121. Establishment of a GPS Network in the Tyhrrenian Basin

Author

Achilli, Vladimiro, Anzidei, M., Bacchetti, M., Baldi, P., Banni, A., Barrile, V., Beinat, A., Benciolini, B., Betti, B., Bitelli, G., Briole, P., Campolo, F., Capone, G., Capra, A., Chadi, M., Crespi, M., Di Filippo, S., Favre, F., Giacobbe, G., Grassi, V., Marsan, P., Marsella, M., Nunnari, G., Puglisi, G., Riguzzi, F., Rondoni, C., Salemi, Giuseppe, Souriau, A., Trabelsi, H., Unguendoli, M., Velardita, R., Vettore, Antonio, and Vittuari, L.

Subjects
Network adjustment, GPS
Published
1992

123. Tyrgeonet: descrizione della rete GPS del Tirreno

Author

Achilli, V., Anzidei, M., Baldi, Paolo, Banni, A., Alberto BEINAT, Benciolini, B., Betti, B., Bitelli, G., Briole, P., Broccio, F., Campolo, F., Capone, G., Capra, A., Chadi, M., Crespi, M., Marco, R., Di Filippo, S., Favre, F., Gasparini, C., Giacobbe, G., Grassi, V., Marchetti, M., Marsan, P., Marsella, M., Nunnari, G., Puglisi, G., Quareni, F., Riguzzi, F., Rondoni, C., Salemi, Giuseppe, Souriau, A., Trabelsi, H., Unguendoli, M., Vecchi, M., Velardita, R., Vettore, A., and Vittuari, L.

Subjects
Rete GPS, Deformazioni crostali, Campo di velocità
Published
1991

135. Primary cardiac Burkitt lymphoma in a child

Author

Meshref, M., primary, Sassolas, F., additional, Schell, M., additional, Chalabreysse, L., additional, Chassagne, C., additional, Mialou, V., additional, Marec Bérard, P., additional, Di Filippo, S., additional, and Bergeron, C., additional

Published
2004
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