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102. Early liver transplantation for severe alcohol-related hepatitis not responding to medical treatment: a prospective controlled study

Author

Louvet, Alexandre, primary, Labreuche, Julien, additional, Moreno, Christophe, additional, Vanlemmens, Claire, additional, Moirand, Romain, additional, Féray, Cyrille, additional, Dumortier, Jérôme, additional, Pageaux, Georges-Philippe, additional, Bureau, Christophe, additional, Chermak, Faïza, additional, Duvoux, Christophe, additional, Thabut, Dominique, additional, Leroy, Vincent, additional, Carbonell, Nicolas, additional, Rolland, Benjamin, additional, Salamé, Ephrem, additional, Anty, Rodolphe, additional, Gournay, Jérôme, additional, Delwaide, Jean, additional, Silvain, Christine, additional, Lucidi, Valerio, additional, Lassailly, Guillaume, additional, Dharancy, Sébastien, additional, Nguyen-Khac, Eric, additional, Samuel, Didier, additional, Duhamel, Alain, additional, Mathurin, Philippe, additional, Berthot, Christophe, additional, Claudet, Sylvie, additional, Doussot, Alexandre, additional, Gérardin, Caroline, additional, Muel, Emilie, additional, Hiriart, Jean-Baptiste, additional, Degré, Delphine, additional, Gustot, Thierry, additional, Bonadona, Agnès, additional, Bordy, Laure, additional, Hilleret, Marie-Noelle, additional, Detry, Olivier, additional, Honoré, Pierre, additional, Meurisse, Nicolas, additional, Boleslawski, Emmanuel, additional, Deplanque, Dominique, additional, El Amrani, Mehdi, additional, Lebuffe, Gilles, additional, Millet, Guillaume, additional, Soret, Daphnée, additional, Truant, Stéphanie, additional, Erard-Poinsot, Domitille, additional, Radenne, Sylvie, additional, Faure, Stéphanie, additional, Gelsi, Eve, additional, Truchi, Régine, additional, Rudler, Marika, additional, Rouleau, Laëtitia, additional, Brenner, Audrey, additional, Larrue, Hélène, additional, Péron, Jean-Marie, additional, Robic, Marie-Angèle, additional, Antonini, Teresa, additional, and Duclos-Vallée, Jean-Charles, additional

Published
2022
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103. R3-AFP score is a new composite tool to refine prediction of hepatocellular carcinoma recurrence after liver transplantation

Author

Costentin, Charlotte, primary, Piñero, Federico, additional, Degroote, Helena, additional, Notarpaolo, Andrea, additional, Boin, Ilka F., additional, Boudjema, Karim, additional, Baccaro, Cinzia, additional, Podestá, Luis G., additional, Bachellier, Philippe, additional, Ettorre, Giuseppe Maria, additional, Poniachik, Jaime, additional, Muscari, Fabrice, additional, Dibenedetto, Fabrizio, additional, Duque, Sergio Hoyos, additional, Salame, Ephrem, additional, Cillo, Umberto, additional, Marciano, Sebastian, additional, Vanlemmens, Claire, additional, Fagiuoli, Stefano, additional, Burra, Patrizia, additional, Van Vlierberghe, Hans, additional, Cherqui, Daniel, additional, Lai, Quirino, additional, Silva, Marcelo, additional, Rubinstein, Fernando, additional, Duvoux, Christophe, additional, Conti, Filomena, additional, Scatton, Olivier, additional, Bernard, Pierre Henri, additional, Francoz, Claire, additional, Durand, Francois, additional, Dharancy, Sébastien, additional, Woehl, Marie-lorraine, additional, Laurent, Alexis, additional, Radenne, Sylvie, additional, Dumortier, Jérôme, additional, Abergel, Armand, additional, Barbier, Louise, additional, Houssel-Debry, Pauline, additional, Pageaux, Georges Philippe, additional, Chiche, Laurence, additional, Deledinghen, Victor, additional, Hardwigsen, Jean, additional, Gugenheim, J., additional, Altieri, M., additional, Hilleret, Marie Noelle, additional, Decaens, Thomas, additional, Chagas, Aline, additional, Costa, Paulo, additional, Cristina de Ataide, Elaine, additional, Quiñones, Emilio, additional, Marciano, Sebastián, additional, Anders, Margarita, additional, Varón, Adriana, additional, Zerega, Alina, additional, Soza, Alejandro, additional, Machaca, Martín Padilla, additional, Arufe, Diego, additional, Menéndez, Josemaría, additional, Zapata, Rodrigo, additional, Vilatoba, Mario, additional, Muñoz, Linda, additional, Menéndez, Ricardo Chong, additional, Maraschio, Martín, additional, McCormack, Lucas, additional, Mattera, Juan, additional, Gadano, Adrian, additional, Fatima Boin, Ilka S.F., additional, Parente García, Jose Huygens, additional, Carrilho, Flair, additional, Magini, Giulia, additional, Miglioresi, Lucia, additional, Gambato, Martina, additional, Di Benedetto, Fabrizio, additional, D’Ambrosio, Cecilia, additional, Vitale, Alessandro, additional, Colledan, Michele, additional, Pinelli, Domenico, additional, Magistri, Paolo, additional, Vennarecci, Giovanni, additional, Colasanti, Marco, additional, Giannelli, Valerio, additional, Pellicelli, Adriano, additional, Baccaro, Cizia, additional, Eduard, Callebout, additional, Samuele, Iesari, additional, Jeroen, Dekervel, additional, Jonas, Schreiber, additional, Jacques, Pirenne, additional, Chris, Verslype, additional, Dirk, Ysebaert, additional, Peter, Michielsen, additional, Valerio, Lucidi, additional, Christophe, Moreno, additional, Olivier, Detry, additional, Jean, Delwaide, additional, Roberto, Troisi, additional, and Paul, Lerut Jan, additional

Published
2022
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104. HCC recurrence in HCV‐infected patients after liver transplantation: SiLVER Study reveals benefits of sirolimus in combination with CNIs – a post‐hoc analysis

Author

Werner, Jens M., Hornung, Matthias, Krah, Rubertha, Götz, Markus, Schnitzbauer, Andreas A., Schlitt, Hans J., Geissler, Edward K., Zülke, Carl, Lamby, Philipp E., Proneth, Andrea, Duvoux, Christophe, Burra, Patrizia, Jauch, Karl‐Walter, Rentsch, Markus, Ganten, Tom M., Schmidt, Jan, Settmacher, Utz, Heise, Michael, Rossi, Giorgio, Cillo, Umberto, Kneteman, Norman, Adam, René, Hoek, Bart, Bachellier, Philippe, Wolf, Philippe, Rostaing, Lionel, Bechstein, Wolf O., Rizell, Magnus, Powell, James, Hidalgo, Ernest, Gugenheim, Jean, Wolters, Heiner, Brockmann, Jens, Roy, André, Mutzbauer, Ingrid, Schlitt, Angela, Beckebaum, Susanne, Graeb, Christian, Nadalin, Silvio, Valente, Umberto, Turrión, Victor Sánchez, Jamieson, Neville, Scholz, Tim, Colledan, Michele, Fändrich, Fred, Becker, Thomas, Söderdahl, Gunnar, Chazouillères, Olivier, Mäkisalo, Heikki, Pageaux, Georges‐Philippe, Steininger, Rudolf, Soliman, Thomas, Jong, Koert P., Pirenne, Jacques, Margreiter, Raimund, Pratschke, Johann, Pinna, Antonio D., Hauss, Johann, Schreiber, Stefan, Strasser, Simone, Klempnauer, Jürgen, Troisi, Roberto I., Bhoori, Sherrie, Lerut, Jan, Bilbao, Itxarone, Klein, Christian G., Königsrainer, Alfred, Otto, Gerd, Mazzaferro, Vincenzo, Neuhaus, Peter, Werner, J, Hornung, M, Krah, R, Gotz, M, Schnitzbauer, A, Schlitt, H, Geissler, E, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Otto, G, Mazzaferro, V, and Neuhaus, P

Subjects
Silver Study, medicine.medical_specialty, Carcinoma, Hepatocellular, Silver, direct-acting antiviral agents, medicine.medical_treatment, 610 Medizin, Subgroup analysis, 030230 surgery, Liver transplantation, Gastroenterology, Group B, 03 medical and health sciences, HEPATOCELLULAR-CARCINOMA, hepatitis C virus infection, hepatocellular carcinoma, liver transplantation, 0302 clinical medicine, Internal medicine, Post-hoc analysis, medicine, Humans, Sirolimus, direct-acting antiviral agent, ddc:610, Transplantation, business.industry, Liver Neoplasms, Immunosuppression, medicine.disease, Hepatitis C, digestive system diseases, Calcineurin, Hepatocellular carcinoma, 030211 gastroenterology & hepatology, Neoplasm Recurrence, Local, business, medicine.drug
Abstract

Factors affecting outcomes in liver transplant (LTx) recipients with hepatocellular carcinoma (HCC) and hepatitis C viral (HCV) infection include the choice of immunosuppression. Here, we analyzed the HCV+ subgroup of patients from the randomized controlled, international SiLVER Study. We performed a post hoc analysis of 166 HCV+ SiLVER Study patients regarding HCC outcome after LTx. Control patients (group A: n=88) received mTOR inhibitor (mTORi)-free, calcineurin inhibitor (CNI)-based versus sirolimus-based immunosuppression (group B: n=78). We found no significant difference regarding HCV-RNA titers between group A and B. Since no effect in group B could be due to variable sirolimus dosing, we split group B into patients receiving sirolimus-based immunosuppression+CNIs for >50% (B1; n=44) or

Published
2020
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105. Recent outcome of liver transplantation for Budd Chiari syndrome - analysis of the european liver transplant registry (ELTR) and affiliated centres

Author

Dongelmans, E., Polak, Wojciech, Adam, R., Karam, Vincent, Pirenne, Jacques, Acarlı, Koray, Hakeem, A., Dhakshinamoorthy, Vignesh, Fedaruk, Dzmitry, Rummo, Oleg, Kılıç, Merve, Nordin, Arno, Fischer, L., Parente, Annalisa, Mirza, Dimitra, Bennet, William, Tokat, Yaman, Faitot, F., Antonelli, Barbara, Muiesan, Paola, Nadalin, Sivio, Berlakovich, Gabrielle, Patch, D., Berrevoet, Frederik, Ribnikar, Mojca, Gerster, Thomas, Savier, E., Gruttadauria, S., Ericzon, B. G., Cuervas-Mons, Valentin, Saborido, B. Perez, Croner, R., Magini, G., Rossi, R., Popescu, I., Razvan, Lazea, Schneeberger, S., Blokzijl, H., Llado, L., Gomez Bravo, Miguel Angel, Duvoux, Christophe, Mezjlik, V., Oniscu, G., Pearson, K., Dayangaç, Murat, Lucidi, Valerio, Detry, Olivier, Rotellar, F., and Murad, S. Darwish

Subjects
European Liver Transplant Registry (ELTR), Budd Chiari Syndrome, Liver Transplant
Published
2022

106. Long-term outcome after living donor liver transplantation compared to donation after brain death in autoimmune liver diseases: Experience from the European Liver Transplant Registry

Author

Heinemann, Melina, Liwinski, Timur, Adam, Rene, Berenguer, Marina, Mirza, Darius, Malek-Hosseini, Seyed Ali, Heneghan, Michael A., Lodge, Peter, Pratschke, Johann, Boudjema, Karim, Paul, Andreas, Zieniewicz, Krzysztof, Fronek, Jiri, Mehrabi, Arianeb, Acarli, Koray, Tokat, Yaman, Coker, Ahmet, Yilmaz, Sezai, Karam, Vincent, Duvoux, Christophe, Lohse, Ansgar W., and Schramm, Christoph

Published
2022
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108. Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma: A Randomized, Multicenter, Open-Label Phase 3 Trial

Author

Geissler, Edward K., Schnitzbauer, Andreas A., Zülke, Carl, Lamby, Philipp E., Proneth, Andrea, Duvoux, Christophe, Burra, Patrizia, Jauch, Karl-Walter, Rentsch, Markus, Ganten, Tom M., Schmidt, Jan, Settmacher, Utz, Heise, Michael, Rossi, Giorgio, Cillo, Umberto, Kneteman, Norman, Adam, René, van Hoek, Bart, Bachellier, Philippe, Wolf, Philippe, Rostaing, Lionel, Bechstein, Wolf O., Rizell, Magnus, Powell, James, Hidalgo, Ernest, Gugenheim, Jean, Wolters, Heiner, Brockmann, Jens, Roy, André, Mutzbauer, Ingrid, Schlitt, Angela, Beckebaum, Susanne, Graeb, Christian, Nadalin, Silvio, Valente, Umberto, Turrión, Victor Sánchez, Jamieson, Neville, Scholz, Tim, Colledan, Michele, Fändrich, Fred, Becker, Thomas, Söderdahl, Gunnar, Chazouillères, Olivier, Mäkisalo, Heikki, Pageaux, Georges-Philippe, Steininger, Rudolf, Soliman, Thomas, de Jong, Koert P., Pirenne, Jacques, Margreiter, Raimund, Pratschke, Johann, Pinna, Antonio D., Hauss, Johann, Schreiber, Stefan, Strasser, Simone, Klempnauer, Jürgen, Troisi, Roberto I., Bhoori, Sherrie, Lerut, Jan, Bilbao, Itxarone, Klein, Christian G., Königsrainer, Alfred, Mirza, Darius F., Otto, Gerd, Mazzaferro, Vincenzo, Neuhaus, Peter, and Schlitt, Hans J.

Published
2016
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109. Patients Treated for HCV Infection and Listed for Liver Transplantation in a French Multicenter Study: What Happens at Five Years?

Author

Meunier, Lucy, Belkacemi, Mohamed, Pageaux, George Philippe, Radenne, Sylvie, Vallet-Pichard, Anaïs, Houssel-Debry, Pauline, Duvoux, Christophe, Botta-Fridlund, Danielle, de Ledinghen, Victor, Conti, Filomena, Anty, Rodolphe, Di Martino, Vincent, Debette-Gratien, Marilyne, Leroy, Vincent, Gerster, Theophile, Lebray, Pascal, Alric, Laurent, Abergel, Armand, Dumortier, Jérôme, and Besch, Camille

Subjects
LIVER transplantation, HEPATITIS C virus, HEPATOCELLULAR carcinoma, DEEP brain stimulation, BRAIN stimulation, PATIENT safety
Abstract

Background: Direct-acting antiviral (DAA) agents for the treatment of hepatitis C virus (HCV) infection have been proven safe and effective in cirrhotic patients awaiting liver transplantation (LT). However, in the long term, data remain minimal regarding the clinical impact of viral eradication on patients listed for decompensated cirrhosis or hepatocellular carcinoma (HCC). We aimed to elucidate the clinical outcomes of patients regarding delisting and the evolution of HCC during the long-term follow-up. Methods: An observational, multicenter, retrospective analysis was carried out on prospectively collected data from HCV-positive patients treated with an interferon-free regimen while awaiting LT in 18 French hospitals. Results: A total of 179 patients were included in the study. The indication for LT was HCC in 104 (58.1%) patients and cirrhosis in 75 (41.9%) patients. The sustained virological response was 84.4% and the treatment was well tolerated. At five years, among 75 patients with cirrhosis treated for HCV, 19 (25.3%) were delisted following improvement after treatment. Predictive factors for delisting highlighted an absence of ascites, MELD score ≤ 15, and Child–Pugh score ≤ 7. No patients with refractory ascites were delisted. Among patients with HCC, 82 (78.9%) were transplanted. The drop-out rate was low (6.7%) and few recurrences of HCC after LT were observed. Conclusions: DAAs are safe and effective in patients awaiting LT for cirrhosis or HCC. A quarter of patients with cirrhosis can be delisted because of clinical improvement. Predictive factors for delisting, as a result of improvement, may assist prescribers, before initiating HCV infection therapy in the long-term perspective. [ABSTRACT FROM AUTHOR]

Published
2023
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111. Influence of the ABO Blood Group System on Hepatocellular Carcinoma Recurrence After Liver Transplantation

Author

Mohkam, Kayvan, primary, Abdallah, Raëf, additional, N’kontchou, Gisèle, additional, Ganne, Nathalie, additional, Barbier, Louise, additional, Salamé, Ephrem, additional, Bucur, Petru, additional, Rayar, Michel, additional, Robin, Fabien, additional, Boudjema, Karim, additional, Pietrasz, Daniel, additional, Cherqui, Daniel, additional, Adam, René, additional, Lim, Chetana, additional, Savier, Eric, additional, Scatton, Olivier, additional, Maulat, Charlotte, additional, Suc, Bertrand, additional, Muscari, Fabrice, additional, Laurent, Alexis, additional, Duvoux, Christophe, additional, Heyd, Bruno, additional, Turco, Célia, additional, Doussot, Alexandre, additional, Merle, Philippe, additional, Antonini, Teresa, additional, Lesurtel, Mickaël, additional, Cossé, Cyril, additional, Durand, François, additional, Soubrane, Olivier, additional, Cauchy, François, additional, and Mabrut, Jean-Yves, additional

Published
2021
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112. International study on the outcome of locoregional therapy for liver transplant in hepatocellular carcinoma beyond Milan criteria

Author

Degroote, Helena, primary, Piñero, Federico, additional, Costentin, Charlotte, additional, Notarpaolo, Andrea, additional, Boin, Ilka F., additional, Boudjema, Karim, additional, Baccaro, Cinzia, additional, Chagas, Aline Lopes, additional, Bachellier, Philippe, additional, Ettorre, Giuseppe Maria, additional, Poniachik, Jaime, additional, Muscari, Fabrice, additional, Di Benedetto, Fabrio, additional, Duque, Sergio Hoyos, additional, Salame, Ephrem, additional, Cillo, Umberto, additional, Gadano, Adrián, additional, Vanlemmens, Claire, additional, Fagiuoli, Stefano, additional, Rubinstein, Fernando, additional, Burra, Patrizia, additional, Cherqui, Daniel, additional, Silva, Marcelo, additional, Van Vlierberghe, Hans, additional, Duvoux, Christophe, additional, Conti, Filomena, additional, Scatton, Olivier, additional, Bernard, Pierre Henri, additional, Francoz, Claire, additional, Durand, Francois, additional, Dharancy, Sébastien, additional, Woehl, Marie-lorraine, additional, Laurent, Alexis, additional, Radenne, Sylvie, additional, Dumortier, Jérôme, additional, Abergel, Armand, additional, Barbier, Louise, additional, Houssel-Debry, Pauline, additional, Pageaux, Georges Philippe, additional, Chiche, Laurence, additional, Deledinghen, Victor, additional, Hardwigsen, Jean, additional, Gugenheim, J., additional, Altieri, M., additional, Hilleret, Marie Noelle, additional, Decaens, Thomas, additional, Chagas, Aline, additional, Costa, Paulo, additional, Cristina de Ataide, Elaine, additional, Quiñones, Emilio, additional, Marciano, Sebastián, additional, Anders, Margarita, additional, Varón, Adriana, additional, Zerega, Alina, additional, Soza, Alejandro, additional, Machaca, Martín Padilla, additional, Arufe, Diego, additional, Menéndez, Josemaría, additional, Zapata, Rodrigo, additional, Vilatoba, Mario, additional, Muñoz, Linda, additional, Menéndez, Ricardo Chong, additional, Maraschio, Martín, additional, Podestá, Luis G., additional, Fauda, M., additional, Campaña, A. Gonzalez, additional, McCormack, Lucas, additional, Mattera, Juan, additional, Gadano, Adrian, additional, Fatima Boin, Ilka S.F., additional, Parente García, Jose Huygens, additional, Carrilho, Flair, additional, Magini, Giulia, additional, Miglioresi, Lucia, additional, Gambato, Martina, additional, Di Benedetto, Fabrizio, additional, D’Ambrosio, Cecilia, additional, Vitale, Alessandro, additional, Colledan, Michele, additional, Pinelli, Domenico, additional, Magistri, Paolo, additional, Vennarecci, Giovanni, additional, Colasanti, Marco, additional, Giannelli, Valerio, additional, Pellicelli, Adriano, additional, Baccaro, Cizia, additional, Degroote, Helena, additional, Eduard, Callebout, additional, Samuele, Iesari, additional, Jeroen, Dekervel, additional, Jonas, Schreiber, additional, Jacques, Pirenne, additional, Chris, Verslype, additional, Dirk, Ysebaert, additional, Peter, Michielsen, additional, Valerio, Lucidi, additional, Christophe, Moreno, additional, Olivier, Detry, additional, Jean, Delwaide, additional, Roberto, Troisi, additional, and Paul, Lerut Jan, additional

Published
2021
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115. 2020 position statement and recommendations of the European Liver and Intestine Transplantation Association (ELITA): management of hepatitis B virus‐related infection before and after liver transplantation

Author

Duvoux, Christophe, primary, Belli, Luca S., additional, Fung, James, additional, Angelico, Mario, additional, Buti, Maria, additional, Coilly, Audrey, additional, Cortesi, Paolo, additional, Durand, François, additional, Féray, Cyrille, additional, Fondevila, Constantino, additional, Lebray, Pascal, additional, Martini, Silvia, additional, Nevens, Frederik, additional, Polak, Wojciech G., additional, Rizzetto, Mario, additional, Volpes, Riccardo, additional, Zoulim, Fabien, additional, Samuel, Didier, additional, and Berenguer, Marina, additional

Published
2021
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116. Protective role of tacrolimus, deleterious role of age and comorbidities in liver transplant recipients with Covid-19: results from the ELITA/ELTR multi-center European study

Author

Belli, L, Fondevila, C, Cortesi, P, Conti, S, Karam, V, Adam, R, Coilly, A, Ericzon, B, Loinaz, C, Cuervas-Mons, V, Zambelli, M, Llado, L, Diaz, F, Invernizzi, F, Patrono, D, Faitot, F, Bhooori, S, Pirenne, J, Perricone, G, Magini, G, Castells, L, Detry, O, Cruchaga, P, Colmenero, J, Berrevoet, F, Rodriguez, G, Ysebaert, D, Radenne, S, Metselaar, H, Morelli, C, De Carlis, L, Polak, W, Duvoux, C, Belli, Luca S, Fondevila, Constantino, Cortesi, Paolo A, Conti, Sara, Karam, Vincent, Adam, Rene, Coilly, Audrey, Ericzon, Bo Goran, Loinaz, Carmelo, Cuervas-Mons, Valentin, Zambelli, Marco, Llado, Laura, Diaz, Fernando, Invernizzi, Federica, Patrono, Damiano, Faitot, Francois, Bhooori, Sherrie, Pirenne, Jacques, Perricone, Giovanni, Magini, Giulia, Castells, Lluis, Detry, Oliver, Cruchaga, Pablo Mart, Colmenero, Jordi, Berrevoet, Frederick, Rodriguez, Gonzalo, Ysebaert, Dirk, Radenne, Sylvie, Metselaar, Herold, Morelli, Cristina, De Carlis, Luciano, Polak, Wojciech G, Duvoux, Christophe, Belli, L, Fondevila, C, Cortesi, P, Conti, S, Karam, V, Adam, R, Coilly, A, Ericzon, B, Loinaz, C, Cuervas-Mons, V, Zambelli, M, Llado, L, Diaz, F, Invernizzi, F, Patrono, D, Faitot, F, Bhooori, S, Pirenne, J, Perricone, G, Magini, G, Castells, L, Detry, O, Cruchaga, P, Colmenero, J, Berrevoet, F, Rodriguez, G, Ysebaert, D, Radenne, S, Metselaar, H, Morelli, C, De Carlis, L, Polak, W, Duvoux, C, Belli, Luca S, Fondevila, Constantino, Cortesi, Paolo A, Conti, Sara, Karam, Vincent, Adam, Rene, Coilly, Audrey, Ericzon, Bo Goran, Loinaz, Carmelo, Cuervas-Mons, Valentin, Zambelli, Marco, Llado, Laura, Diaz, Fernando, Invernizzi, Federica, Patrono, Damiano, Faitot, Francois, Bhooori, Sherrie, Pirenne, Jacques, Perricone, Giovanni, Magini, Giulia, Castells, Lluis, Detry, Oliver, Cruchaga, Pablo Mart, Colmenero, Jordi, Berrevoet, Frederick, Rodriguez, Gonzalo, Ysebaert, Dirk, Radenne, Sylvie, Metselaar, Herold, Morelli, Cristina, De Carlis, Luciano, Polak, Wojciech G, and Duvoux, Christophe

Abstract

BACKGROUND AND AIMS: Despite concerns that liver transplant (LT) recipients may be at increased risk of unfavorable outcomes from COVID-19 due the high prevalence of co-morbidities, immunosuppression and ageing, a detailed analysis of their effects in large studies is lacking.METHODS: Data from adult LT recipients with laboratory confirmed SARS-CoV2 infection were collected across Europe. All consecutive patients with symptoms were included in the analysis.RESULTS: Between March 1st and June 27th2020, data from 243 adult symptomatic cases from 36 centers and 9 countries were collected. Thirty-nine (16%) were managed as outpatients while 204 (84%) required hospitalization including admission to the ICU (39/204, 19.1%). Forty-nine (20.2%) patients died after a median of 13.5 (10-23) days, respiratory failure was the major cause. After multivariable Cox regression analysis, age >70 (HR, 4.16; 95% CI, 1.78-9.73) had a negative effect and tacrolimus (TAC) use (HR, 0.55; 95% CI, 0.31-0.99) had a positive independent effect on survival. The role of co-morbidities was strongly influenced by the dominant effect of age where comorbidities increased with the increasing age of the recipients. In a second model excluding age, both diabetes (HR, 1.95; 95% CI, 1.06-3.58) and chronic kidney disease (HR, 1.97; 95% CI, 1.05-3.67) emerged as associated with death CONCLUSIONS: Twenty-five per cent of patients requiring hospitalization for Covid-19 died, the risk being higher in patients older than 70 and with medical co-morbidities, such as impaired renal function and diabetes. Conversely, the use of TAC was associated with a better survival thus encouraging clinicians to keep TAC at the usual dose.

Published
2021

117. Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe:Results of the ELITA/EF-CLIF collaborative study (ECLIS)

Author

Belli, Luca S., Duvoux, Christophe, Artzner, Thierry, Bernal, William, Conti, Sara, Cortesi, Paolo A., Sacleux, Sophie Caroline, Pageaux, George Philippe, Radenne, Sylvie, Trebicka, Jonel, Fernandez, Javier, Perricone, Giovanni, Piano, Salvatore, Nadalin, Silvio, Morelli, Maria C., Martini, Silvia, Polak, Wojciech G., Zieniewicz, Krzysztof, Toso, Christian, Berenguer, Marina, Iegri, Claudia, Invernizzi, Federica, Volpes, Riccardo, Karam, Vincent, Adam, René, Faitot, François, Rabinovich, Liane, Saliba, Faouzi, Meunier, Lucy, Lesurtel, Mickael, Uschner, Frank E., Fondevila, Costantino, Michard, Baptiste, Coilly, Audrey, Meszaros, Magdalena, Poinsot, Domitille, Schnitzbauer, Andreas, De Carlis, Luciano G., Fumagalli, Roberto, Angeli, Paolo, Arroyo, Vincente, Jalan, Rajiv, Belli, Luca S., Duvoux, Christophe, Artzner, Thierry, Bernal, William, Conti, Sara, Cortesi, Paolo A., Sacleux, Sophie Caroline, Pageaux, George Philippe, Radenne, Sylvie, Trebicka, Jonel, Fernandez, Javier, Perricone, Giovanni, Piano, Salvatore, Nadalin, Silvio, Morelli, Maria C., Martini, Silvia, Polak, Wojciech G., Zieniewicz, Krzysztof, Toso, Christian, Berenguer, Marina, Iegri, Claudia, Invernizzi, Federica, Volpes, Riccardo, Karam, Vincent, Adam, René, Faitot, François, Rabinovich, Liane, Saliba, Faouzi, Meunier, Lucy, Lesurtel, Mickael, Uschner, Frank E., Fondevila, Costantino, Michard, Baptiste, Coilly, Audrey, Meszaros, Magdalena, Poinsot, Domitille, Schnitzbauer, Andreas, De Carlis, Luciano G., Fumagalli, Roberto, Angeli, Paolo, Arroyo, Vincente, and Jalan, Rajiv

Abstract

Background & Aims: Liver transplantation (LT) has been proposed as an effective salvage therapy even for the sickest patients with acute-on-chronic liver failure (ACLF). This large collaborative study was designed to assess the current clinical practice and outcomes of patients with ACLF who are wait-listed for LT in Europe. Methods: This was a retrospective study including 308 consecutive patients with ACLF, listed in 20 centres across 8 European countries, from January 2018 to June 2019. Results: A total of 2,677 patients received a LT: 1,216 (45.4%) for decompensated cirrhosis. Of these, 234 (19.2%) had ACLF at LT: 58 (4.8%) had ACLF-1, 78 (6.4%) had ACLF-2, and 98 (8.1%) had ACLF-3. Wide variations were observed amongst countries: France and Germany had high rates of ACLF-2/3 (27–41%); Italy, Switzerland, Poland and the Netherlands had medium rates (9–15%); and the United Kingdom and Spain had low rates (3–5%) (p <0.0001). The 1-year probability of survival after LT for patients with ACLF was 81% (95% CI 74–87). Pre-LT arterial lactate levels >4 mmol/L (hazard ratio [HR] 3.14; 95% CI 1.37–7.19), recent infection from multidrug resistant organisms (HR 3.67; 95% CI 1.63–8.28), and renal replacement therapy (HR 2.74; 95% CI 1.37–5.51) were independent predictors of post-LT mortality. During the same period, 74 patients with ACLF died on the waiting list. In an intention-to-treat analysis, 1-year survival of patients with ACLF on the LT waiting list was 73% for ACLF-1 or -2 and 50% for ACLF-3. Conclusion: The results reveal wide variations in the listing of patients with ACLF in Europe despite favourable post-LT survival. Risk factors for mortality were identified, enabling a more precise prognostic assessment of patients with ACLF. Lay summary: Acute-on-chronic liver failure (ACLF) is a severe clinical condition for which liver transplantation is an effective therapeutic option. This study has demonstrated that in Europe, referral and access to liver t

Published
2021

118. Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe: results of the ELITA/EF-CLIF collaborative study (ECLIS)

Author

Belli, L, Duvoux, C, Artzner, T, Bernal, W, Conti, S, Cortesi, P, Sacleux, S, Pageaux, G, Radenne, S, Trebicka, J, Fernandez, J, Perricone, G, Piano, S, Nadalin, S, Morelli, M, Martini, S, Polak, W, Zieniewicz, K, Toso, C, Berenguer, M, Iegri, C, Invernizzi, F, Volpes, R, Karam, V, Adam, R, Faitot, F, Rabinovich, L, Saliba, F, Meunier, L, Lesurtel, M, Uschner, F, Fondevila, C, Michard, B, Coilly, A, Meszaros, M, Poinsot, D, Schnitzbauer, A, De Carlis, L, Fumagalli, R, Angeli, P, Arroyo, V, Jalan, R, Fagiuoli, S, Belli, Luca S, Duvoux, Christophe, Artzner, Thierry, Bernal, William, Conti, Sara, Cortesi, Paolo A, Sacleux, Sophie-Caroline, Pageaux, George-Philippe, Radenne, Sylvie, Trebicka, Jonel, Fernandez, Javier, Perricone, Giovanni, Piano, Salvatore, Nadalin, Silvio, Morelli, Maria C, Martini, Silvia, Polak, Wojciech G, Zieniewicz, Krzysztof, Toso, Christian, Berenguer, Marina, Iegri, Claudia, Invernizzi, Federica, Volpes, Riccardo, Karam, Vincent, Adam, René, Faitot, Francoise, Rabinovich, Liane, Saliba, Faouzi, Meunier, Lucy, Lesurtel, Mickael, Uschner, Frank E, Fondevila, Costantino, Michard, Baptiste, Coilly, Audrey, Meszaros, Magdalena, Poinsot, Domitille, Schnitzbauer, Andreas, De Carlis, Luciano G, Fumagalli, Roberto, Angeli, Paolo, Arroyo, Vincente, Jalan, Rajiv, FAGIUOLI, STEFANO, Belli, L, Duvoux, C, Artzner, T, Bernal, W, Conti, S, Cortesi, P, Sacleux, S, Pageaux, G, Radenne, S, Trebicka, J, Fernandez, J, Perricone, G, Piano, S, Nadalin, S, Morelli, M, Martini, S, Polak, W, Zieniewicz, K, Toso, C, Berenguer, M, Iegri, C, Invernizzi, F, Volpes, R, Karam, V, Adam, R, Faitot, F, Rabinovich, L, Saliba, F, Meunier, L, Lesurtel, M, Uschner, F, Fondevila, C, Michard, B, Coilly, A, Meszaros, M, Poinsot, D, Schnitzbauer, A, De Carlis, L, Fumagalli, R, Angeli, P, Arroyo, V, Jalan, R, Fagiuoli, S, Belli, Luca S, Duvoux, Christophe, Artzner, Thierry, Bernal, William, Conti, Sara, Cortesi, Paolo A, Sacleux, Sophie-Caroline, Pageaux, George-Philippe, Radenne, Sylvie, Trebicka, Jonel, Fernandez, Javier, Perricone, Giovanni, Piano, Salvatore, Nadalin, Silvio, Morelli, Maria C, Martini, Silvia, Polak, Wojciech G, Zieniewicz, Krzysztof, Toso, Christian, Berenguer, Marina, Iegri, Claudia, Invernizzi, Federica, Volpes, Riccardo, Karam, Vincent, Adam, René, Faitot, Francoise, Rabinovich, Liane, Saliba, Faouzi, Meunier, Lucy, Lesurtel, Mickael, Uschner, Frank E, Fondevila, Costantino, Michard, Baptiste, Coilly, Audrey, Meszaros, Magdalena, Poinsot, Domitille, Schnitzbauer, Andreas, De Carlis, Luciano G, Fumagalli, Roberto, Angeli, Paolo, Arroyo, Vincente, Jalan, Rajiv, and FAGIUOLI, STEFANO

Abstract

Background and aims: Liver transplantation (LT) has been proposed to be an effective salvage therapy even for the sickest patients with acute-on-chronic liver failure (ACLF). This large collaborative study was designed to address the current clinical practice and outcomes of ACLF patients wait listed (WL) for LT in Europe. Methods: Retrospective study including 308 consecutive ACLF patients, listed in 20 centres across 8 European countries, from January 2018 to June 2019. Results: 2677 patients received a LT, 1216 (45.4%) for decompensated cirrhosis (DC). Of these, 234 (19.2%) had ACLF at LT: ACLF-1, 58 (4.8%); ACLF-2, 78 (6.4%); and ACLF-3, 98 (8.1%). Wide variations were observed amongst countries: France and Germany had high rates of ACLF-2/3 (27-41%); Italy, Switzerland, Poland and Netherlands had medium rates (9-15%); and United Kingdom and Spain had low rates (3-5%) (p <.0001). One-year probability of survival after LT for patients with ACLF was 81% (95% CI 74-87). Pre-LT arterial lactate levels >4 mmol/L (HR 3.14, 95% CI 1.37-7.19), recent infection from multi-drug resistant organisms (HR 3.67, 95% CI 1.63-8.28), and renal replacement therapy (HR 2.74, 95% CI 1.37-5.51) were independent predictors of post-LT mortality. During the same period, 74 patients with ACLF died on the WL. In an intention-to-treat analysis, one-year survival of ACLF patients on the LT WL was 73% for ACLF-1 or -2 and 50% for ACLF-3. Conclusion: The results reveal wide variations in listing patients with ACLF in Europe despite favorable post-LT survival. Risk factors for mortality were identified, allowing a more precise prognostic assessment of ACLF patients for potential LT. Lay summary: Acute on chronic liver failure (ACLF) is a severe clinical condition for which liver transplantation is an effective therapeutic option. This study has demonstrated that in Europe, referral and access to liver transplantation (LT) for patients with ACLF needs to be harmonized to avoid inequities.

Published
2021

119. Protective Role of Tacrolimus, Deleterious Role of Age and Comorbidities in Liver Transplant Recipients With Covid-19:Results From the ELITA/ELTR Multi-center European Study

Author

Belli, Luca S., Fondevila, Constantino, Cortesi, Paolo A., Conti, Sara, Karam, Vincent, Adam, Rene, Coilly, Audrey, Ericzon, Bo Goran, Loinaz, Carmelo, Cuervas-Mons, Valentin, Zambelli, Marco, Llado, Laura, Diaz-Fontenla, Fernando, Invernizzi, Federica, Patrono, Damiano, Faitot, Francois, Bhooori, Sherrie, Pirenne, Jacques, Perricone, Giovanni, Magini, Giulia, Castells, Lluis, Detry, Oliver, Cruchaga, Pablo Mart, Colmenero, Jordi, Berrevoet, Frederick, Rodriguez, Gonzalo, Ysebaert, Dirk, Radenne, Sylvie, Metselaar, Herold, Morelli, Cristina, De Carlis, Luciano G., Polak, Wojciech G., Duvoux, Christophe, Belli, Luca S., Fondevila, Constantino, Cortesi, Paolo A., Conti, Sara, Karam, Vincent, Adam, Rene, Coilly, Audrey, Ericzon, Bo Goran, Loinaz, Carmelo, Cuervas-Mons, Valentin, Zambelli, Marco, Llado, Laura, Diaz-Fontenla, Fernando, Invernizzi, Federica, Patrono, Damiano, Faitot, Francois, Bhooori, Sherrie, Pirenne, Jacques, Perricone, Giovanni, Magini, Giulia, Castells, Lluis, Detry, Oliver, Cruchaga, Pablo Mart, Colmenero, Jordi, Berrevoet, Frederick, Rodriguez, Gonzalo, Ysebaert, Dirk, Radenne, Sylvie, Metselaar, Herold, Morelli, Cristina, De Carlis, Luciano G., Polak, Wojciech G., and Duvoux, Christophe

Abstract

Background and Aims: Despite concerns that liver transplant (LT) recipients may be at increased risk of unfavorable outcomes from COVID-19 due the high prevalence of co-morbidities, immunosuppression and ageing, a detailed analysis of their effects in large studies is lacking. Methods: Data from adult LT recipients with laboratory confirmed SARS-CoV2 infection were collected across Europe. All consecutive patients with symptoms were included in the analysis. Results: Between March 1 and June 27, 2020, data from 243 adult symptomatic cases from 36 centers and 9 countries were collected. Thirty-nine (16%) were managed as outpatients while 204 (84%) required hospitalization including admission to the ICU (39 of 204, 19.1%). Forty-nine (20.2%) patients died after a median of 13.5 (10–23) days, respiratory failure was the major cause. After multivariable Cox regression analysis, age >70 (HR, 4.16; 95% CI, 1.78–9.73) had a negative effect and tacrolimus (TAC) use (HR, 0.55; 95% CI, 0.31–0.99) had a positive independent effect on survival. The role of co-morbidities was strongly influenced by the dominant effect of age where comorbidities increased with the increasing age of the recipients. In a second model excluding age, both diabetes (HR, 1.95; 95% CI, 1.06–3.58) and chronic kidney disease (HR, 1.97; 95% CI, 1.05–3.67) emerged as associated with death Conclusions: Twenty-five percent of patients requiring hospitalization for COVID-19 died, the risk being higher in patients older than 70 and with medical co-morbidities, such as impaired renal function and diabetes. Conversely, the use of TAC was associated with a better survival thus encouraging clinicians to keep TAC at the usual dose.

Published
2021

120. COVID-19 in liver transplant candidates:Pretransplant and post-transplant outcomes - An ELITA/ELTR multicentre cohort study

Author

Belli, Luca Saverio, Duvoux, Christophe, Cortesi, Paolo Angelo, Facchetti, Rita, Iacob, Speranta, Perricone, Giovanni, Radenne, Sylvie, Conti, Sara, Patrono, Damiano, Berlakovich, Gabriela, Hann, Angus, Pasulo, Luisa, Castells, Lluis, Faitot, Francois, Detry, Olivier, Invernizzi, Federica, Magini, Giulia, De Simone, Paolo, Kounis, Ilias, Morelli, Maria Cristina, Diáz Fontenla, Fernando, Ericzon, Bo Göran, Loinaz, Carmelo, Johnston, Chris, Gheorghe, Liliana, Lesurtel, Mickael, Romagnoli, Renato, Kollmann, Dagmar, Perera, M. Thamara P.R., Fagiuoli, Stefano, Mirza, Darius, Coilly, Audrey, Toso, Christian, Zieniewicz, Krzysztof, Elkrief, Laure, Karam, Vincent, Adam, Rene, Den Hoed, Caroline, Merli, Marco, Puoti, Massimo, De Carlis, Luciano, Oniscu, Gabriel C., Piano, Salvatore, Angeli, Paolo, Fondevila, Constantino, Polak, Wojciech G., Belli, Luca Saverio, Duvoux, Christophe, Cortesi, Paolo Angelo, Facchetti, Rita, Iacob, Speranta, Perricone, Giovanni, Radenne, Sylvie, Conti, Sara, Patrono, Damiano, Berlakovich, Gabriela, Hann, Angus, Pasulo, Luisa, Castells, Lluis, Faitot, Francois, Detry, Olivier, Invernizzi, Federica, Magini, Giulia, De Simone, Paolo, Kounis, Ilias, Morelli, Maria Cristina, Diáz Fontenla, Fernando, Ericzon, Bo Göran, Loinaz, Carmelo, Johnston, Chris, Gheorghe, Liliana, Lesurtel, Mickael, Romagnoli, Renato, Kollmann, Dagmar, Perera, M. Thamara P.R., Fagiuoli, Stefano, Mirza, Darius, Coilly, Audrey, Toso, Christian, Zieniewicz, Krzysztof, Elkrief, Laure, Karam, Vincent, Adam, Rene, Den Hoed, Caroline, Merli, Marco, Puoti, Massimo, De Carlis, Luciano, Oniscu, Gabriel C., Piano, Salvatore, Angeli, Paolo, Fondevila, Constantino, and Polak, Wojciech G.

Abstract

Objective Explore the impact of COVID-19 on patients on the waiting list for liver transplantation (LT) and on their post-LT course. Design Data from consecutive adult LT candidates with COVID-19 were collected across Europe in a dedicated registry and were analysed. Results From 21 February to 20 November 2020, 136 adult cases with laboratory-confirmed SARS-CoV-2 infection from 33 centres in 11 European countries were collected, with 113 having COVID-19. Thirty-seven (37/113, 32.7%) patients died after a median of 18 (10-30) days, with respiratory failure being the major cause (33/37, 89.2%). The 60-day mortality risk did not significantly change between first (35.3%, 95% CI 23.9% to 50.0%) and second (26.0%, 95% CI 16.2% to 40.2%) waves. Multivariable Cox regression analysis showed Laboratory Model for End-stage Liver Disease (Lab-MELD) score of ≥15 (Model for End-stage Liver Disease (MELD) score 15-19, HR 5.46, 95% CI 1.81 to 16.50; MELD score≥20, HR 5.24, 95% CI 1.77 to 15.55) and dyspnoea on presentation (HR 3.89, 95% CI 2.02 to 7.51) being the two negative independent factors for mortality. Twenty-six patients underwent an LT after a median time of 78.5 (IQR 44-102) days, and 25 (96%) were alive after a median follow-up of 118 days (IQR 31-170). Conclusions Increased mortality in LT candidates with COVID-19 (32.7%), reaching 45% in those with decompensated cirrhosis (DC) and Lab-MELD score of ≥15, was observed, with no significant difference between first and second waves of the pandemic. Respiratory failure was the major cause of death. The dismal prognosis of patients with DC supports the adoption of strict preventative measures and the urgent testing of vaccination efficacy in this population. Prior SARS-CoV-2 symptomatic infection did not affect early post-transplant survival (96%).

Published
2021

121. AS010 - Reassessment of the risk of recurrence (R3) after liver transplantation for HCC: validation of the R3 v.2 score and comparison with existing models: results of a multinational analysis in 2,444 patients

Author

Costentin, Charlotte, Pinero, Federico, Degroote, Helena, Notarpaolo, Andrea, Boin, Ilka, Boudjema, Karim, Baccaro, Cinzia, Podestá, Luis G., Bachellier, Philippe, Ettorre, Giuseppe Maria, Poniachik, Jaime, Muscari, Fabrice, Di Benedetto, Fabrizio, Duque, Sergio Hoyos, Salamé, Ephrem, Cillo, Umberto, Gadano, Adrian, Vanlemmens, Claire, Fagiuoli, Stefano, Rubinstein, Fernando, Burra, Patrizia, Van Vlierberghe, Hans, Silva, Marcelo, and Duvoux, Christophe

Published
2020
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122. Long-Term Results of Combined Liver-Kidney Transplantation for Primary Hyperoxaluria Type 1: The French Experience

Author

Compagnon, Philippe, Metzler, Philippe, Samuel, Didier, Camus, Christophe, Niaudet, Patrick, Durrbach, Antoine, Lang, Philippe, Azoulay, Daniel, Duvoux, Christophe, Bayle, Francois, Rivalan, Joseph, Merville, Pierre, Pascal, Gerard, Thervet, Eric, Bensman, Albert, Rostaing, Lionel, Deschenes, Georges, Morcet, Jeff, Feray, Cyrille, and Boudjema, Karim

Published
2014
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123. Mortality after Transplantation for Hepatocellular Carcinoma: A Study from the European Liver Transplant Registry

Author

Pommergaard, Hans-Christian, Arendtsen Rostved, Andreas, Adam, R. (René), Rasmussen, Allan, Salizzoni, Mauro, Gómez Bravo, Miguel Angel, Cherqui, Daniel, Simone, Paolo De, Houssel-Debry, Pauline, Mazzaferro, Vincenzo, Soubrane, Olivier, García Valdecasas, Juan Carlos, Fabregat Prous, Joan, Pinna, Antonio D., O'Grady, John, Karam, Vincent, Duvoux, Christophe, Thygesen, Lau Caspar, European Liver and Intestine Transplant Association (ELITA), University of Copenhagen = Københavns Universitet (UCPH), Modèles de Cellules Souches Malignes et Thérapeutiques, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Molinette Hospital, Hospital Universitario Virgen del Rocío [Sevilla], University of Pisa - Università di Pisa, Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Hôpital Beaujon, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), King's College Hospital (KCH), CHU Henri Mondor [Créteil], University of Southern Denmark (SDU), University of Copenhagen = Københavns Universitet (KU), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and CHU Henri Mondor

Subjects
medicine.medical_specialty, Cirrhosis, Hepatocellular carcinoma, Propensity score calibration, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Non-cirrhotic liver, Liver transplantation, lcsh:RC254-282, Gastroenterology, Prognosis, Unmeasured confounding, Càncer de fetge, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Original Paper, Transplantation of organs, Hepatology, Proportional hazards model, business.industry, Hazard ratio, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Confidence interval, 3. Good health, Transplantation, Trasplantament d'òrgans, Oncology, 030220 oncology & carcinogenesis, Propensity score matching, 030211 gastroenterology & hepatology, business, Liver cancer
Abstract

Background and Aims: Prognosis after liver transplantation differs between hepatocellular carcinoma (HCC) arising in cirrhotic and non-cirrhotic livers and aetiology is poorly understood. The aim was to investigate differences in mortality after liver transplantation between these patients. Methods: We included patients from the European Liver Transplant Registry transplanted due to HCC from 1990 to November 2016 and compared cirrhotic and non-cirrhotic patients using propensity score (PS) calibration of Cox regression estimates to adjust for unmeasured confounding. Results: We included 22,787 patients, of whom 96.5% had cirrhosis. In the unadjusted analysis, non-cirrhotic patients had an increased risk of overall mortality with a hazard ratio (HR) of 1.37 (95% confidence interval [CI] 1.23–1.52). However, the HR approached unity with increasing adjustment and was 1.11 (95% CI 0.99–1.25) when adjusted for unmeasured confounding. Unadjusted, non-cirrhotic patients had an increased risk of HCC-specific mortality (HR 2.62, 95% CI 2.21–3.12). After adjustment for unmeasured confounding, the risk remained significantly increased (HR 1.62, 95% CI 1.31–2.00). Conclusions: Using PS calibration, we showed that HCC in non-cirrhotic liver has similar overall mortality, but higher HCC-specific mortality. This may be a result of a more aggressive cancer form in the non-cirrhotic liver as higher mortality could not be explained by tumour characteristics or other prognostic variables.

Published
2020
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124. Temporal Trends and Outcomes in Liver Transplantation for Recipients With HIV Infection in Europe and United States

Author

Campos-Varela, I, Dodge, J, Berenguer, M, Adam, R, Samuel, D, Di Benedetto, F, Karam, V, Belli, L, Duvoux, C, Terrault, N, Campos-Varela, Isabel, Dodge, Jennifer L, Berenguer, Marina, Adam, René, Samuel, Didier, Di Benedetto, Fabrizio, Karam, Vincent, Belli, Luca S, Duvoux, Christophe, Terrault, Norah A, Campos-Varela, I, Dodge, J, Berenguer, M, Adam, R, Samuel, D, Di Benedetto, F, Karam, V, Belli, L, Duvoux, C, Terrault, N, Campos-Varela, Isabel, Dodge, Jennifer L, Berenguer, Marina, Adam, René, Samuel, Didier, Di Benedetto, Fabrizio, Karam, Vincent, Belli, Luca S, Duvoux, Christophe, and Terrault, Norah A

Abstract

Background: We evaluated trends and outcomes of liver transplantation (LT) recipients with/without HIV infection. Methods: LT recipients between 2008 and 2015 from the United Network for Organ Sharing and Organ Procurement and Transplantation Network and European Liver Transplant Registry were included. Trends and characteristics related to survival among LT recipients with HIV infection were determined. Results: Among 73 206 LT patients, 658 (0.9%) were HIV-infected. The proportion of LT HIV-infected did not change over time (P-trend = 0.16). Hepatitis C virus (HCV) as indication for LT decreased significantly for HIV-infected and HIV-uninfected patients (P-trends = 0.008 and <0.001). Three-year cumulative graft survival in LT recipients with and without HIV infection was 64.4% and 77.3%, respectively (P < 0.001), with improvements over time for both, but with HIV-infected patients having greater improvements (P-trends = 0.02 and 0.03). Adjusted risk of graft loss was 41% higher in HIV-infected versus HIV-uninfected (adjusted hazard ratio [aHR], 1.41; P < 0.001). Among HIV-infected, model of end-stage liver disease (aHR, 1.04; P < 0.001), body mass index <21 kg/m (aHR, 1.61; P = 0.006), and HCV (aHR, 1.83; P < 0.001) were associated with graft loss, whereas more recent period of LT 2012-2015 (aHR, 0.58; P = 0.001) and donor with anoxic cause of death (aHR, 0.51; P = 0.007) were associated with lower risk of graft loss. Conclusions: Patients with HIV infection account for only 1% of LTs in United States and Europe, with fewer LT for HCV disease over time. A static rate of LT among HIV-infected patients may reflect improvements in cirrhosis management and/or persistent barriers to LT. Graft and patient survival among HIV-infected LT recipients have shown improvement over time.

Published
2020

125. COVID-19 in liver transplant recipients: preliminary data from the ELITA/ELTR registry

Author

Belli, L, Duvoux, C, Karam, V, Adam, R, Cuervas-Mons, V, Pasulo, L, Loinaz, C, Invernizzi, F, Patrono, D, Bhoori, S, Ciccarelli, O, Morelli, M, Castells, L, Lopez-Lopez, V, Conti, S, Fondevila, C, Polak, W, Belli, Luca S, Duvoux, Christophe, Karam, Vincent, Adam, Rene, Cuervas-Mons, Valentin, Pasulo, Luisa, Loinaz, Carmelo, Invernizzi, Federica, Patrono, Damiano, Bhoori, Sherrie, Ciccarelli, Olga, Morelli, Maria Cristina, Castells, Lluis, Lopez-Lopez, Victor, Conti, Sara, Fondevila, Costantino, Polak, Wojchiech, Belli, L, Duvoux, C, Karam, V, Adam, R, Cuervas-Mons, V, Pasulo, L, Loinaz, C, Invernizzi, F, Patrono, D, Bhoori, S, Ciccarelli, O, Morelli, M, Castells, L, Lopez-Lopez, V, Conti, S, Fondevila, C, Polak, W, Belli, Luca S, Duvoux, Christophe, Karam, Vincent, Adam, Rene, Cuervas-Mons, Valentin, Pasulo, Luisa, Loinaz, Carmelo, Invernizzi, Federica, Patrono, Damiano, Bhoori, Sherrie, Ciccarelli, Olga, Morelli, Maria Cristina, Castells, Lluis, Lopez-Lopez, Victor, Conti, Sara, Fondevila, Costantino, and Polak, Wojchiech

Published
2020

126. Efficacy of Sofosbuvir and Daclatasvir in Patients With Fibrosing Cholestatic Hepatitis C After Liver Transplantation

Author

Leroy, Vincent, Dumortier, Jérôme, Coilly, Audrey, Sebagh, Mylène, Fougerou-Leurent, Claire, Radenne, Sylvie, Botta, Danielle, Durand, François, Silvain, Christine, Lebray, Pascal, Houssel-Debry, Pauline, Kamar, Nassim, DʼAlteroche, Louis, Petrov-Sanchez, Ventzislava, Diallo, Alpha, Pageaux, Georges-Philippe, Duclos-Vallee, Jean-Charles, Bellissant, Eric, Botta-Fridlund, Danielle, Dumortier, Jérôme, Duvoux, Christophe, Fougerou-Leurent, Claire, Renault, Alain, Rohel, Alexandra, Roque, Anne-Marie, Taburet, Anne-Marie, and Veislinger, Aurélie

Published
2015
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127. COVID-19 in Liver Transplant Candidates: Pre- and Post-Transplant Outcome

Author

Belli, Luca Saverio, primary, Duvoux, Christophe, additional, Cortesi, Paolo, additional, Iacob, Speranta, additional, Facchetti, Rita, additional, Radenne, Sylvie, additional, Giovanni, Perricone, additional, Conti, Sara, additional, Patrono, Damiano, additional, Berlakovic, Gabriela, additional, Hann, Angus, additional, Pasulo, Luisa, additional, Castells, Lluis, additional, Faitot, Francois, additional, Detry, Olivier, additional, Invernzzi, Federica, additional, MAgini, Giulia, additional, De Simone, Paolo, additional, Kounis, Ilias, additional, Morelli, Cristina, additional, Diaz-Fontenla, Fernando, additional, Ericzon, Bo Goran, additional, Loinaz, Carmelo, additional, Gheorghe, Liana, additional, lesurtel, mickael, additional, Romagnoli, Renato, additional, Kollmann, Dagmar, additional, Perera, Thamara, additional, Fagiuoli, Stefano, additional, Mirza, Darius, additional, Coilly, Audrey, additional, Toso, Christian, additional, zieniewicz, krzysztof, additional, Elkrief, Laurie, additional, Karam, Vincent, additional, Den Hoed, Caroline, additional, Merli, Marco, additional, Puoti, Massimo, additional, fumagalli, Roberto, additional, Luciano, De Carlis, additional, Fondevila, Costantino, additional, and Polak, Wojciech, additional

Published
2021
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128. THU-511 - Long-term outcome following liver transplantation for chronic liver disease in intensive care unit: the French nationwide experience

Author

Meszaros, Magdalena, Saliba, Faouzi, Francoz, Claire, Duvoux, Christophe, Conti, Filomena, Faitot, François, Houssel-Debry, Pauline, Hardwigsen, Jean, Hilleret, Marie-Noëlle, Vanlemmens, Claire, Salamé, Ephrem, Kamar, Nassim, Gugenheim, Jean, Abergel, Armand, Perignon, Claire, Chiche, Laurence, Gratien, Maryline Debette, Mabrut, Jean-Yves, Dharancy, Sebastien, Dumortier, Jérôme, Pageaux, Georges-Philippe, and Artru, Florent

Published
2023
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129. THU-498 - Evaluation of a delayed liver transplant strategy for patients listed for hepatocellular carcinoma treated with resection or thermo-ablation as a bridge to liver transplantation; the DELTAS-HCC study

Author

Lamarque, Catherine, Segaux, Lauriane, Abergel, Armand, Bachellier, Philippe, Chermak, Faiza, Coilly, Audrey, Conti, Filomena, Decaens, Thomas, Dharancy, Sebastien, Di Martino, Vincent, Dumortier, Jérôme, Francoz, Claire, Gugenheim, Jean, Hardwigsen, Jean, Muscari, Fabrice, Radenne, Sylvie, Salamé, Ephrem, Uguen, Thomas, Bedoya, José Ursic, Antoine, Corinne, Leroy, Vincent, Oubaya, Nadia, and Duvoux, Christophe

Published
2023
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136. Hepatitis B virus reactivation in transplant patients treated for hepatitis C recurrence: Prophylaxis makes the difference

Author

Mouna, Lina, Rossignol, Emilie, Tateo, Mariagrazia, Coilly, Audrey, Duclos-Vallée, Jean-Charles, Duvoux, Christophe, Durand, François, Tran, Albert, Radenne, Sylvie, Canva-Delcambre, Valerie, Houssel-Debry, Pauline, Dumortier, Jérôme, Conti, Filomena, de Ledinghen, Victor, Leroy, Vincent, Kamar, Nassim, Di Martino, Vincent, Moreno, Christophe, Botta Fridlund, Danielle, d'Alteroche, Louis, Lebray, Pascal, Perre, Philippe, Besch, Camille, Silvain, Christine, Habersetzer, François, Debette-Gratien, Maryline, Abergel, Armando, Diallo, Alpha, Samuel, Didier, Roque-Afonso, Anne-Marie, and Pageaux, Georges-Philippe

Published
2019
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139. Impact of tumour differentiation to select patients before liver transplantation for hepatocellular carcinoma

Author

Decaens, Thomas, Roudot-Thoraval, Françoise, Badran, Hanaa, Wolf, Philippe, Durand, François, Adam, Rene, Boillot, Olivier, Vanlemmens, Claire, Gugenheim, Jean, Dharancy, Sébastien, Bernard, Pierre-Henri, Boudjema, Karim, Calmus, Yvon, Hardwigsen, Jean, Ducerf, Christian, Pageaux, Georges Philippe, Hilleret, Marie-Noelle, Chazouillères, Olivier, Cherqui, Daniel, Mallat, Ariane, and Duvoux, Christophe

Published
2011
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142. Time to Conversion to an Everolimus‐Based Regimen: Renal Outcomes in Liver Transplant Recipients From the EVEROLIVER Registry

Author

Saliba, Faouzi, primary, Dharancy, Sébastien, additional, Salamé, Ephrem, additional, Conti, Filoména, additional, Eyraud, Daniel, additional, Radenne, Sylvie, additional, Antonini, Térésa, additional, Guillaud, Olivier, additional, Guguenheim, Jean, additional, Neau‐Cransac, Martine, additional, Demartin, Eléonora, additional, Lasailly, Guillaume, additional, Duvoux, Christophe, additional, Sobesky, Rodolphe, additional, Coilly, Audrey, additional, Tresson, Sylvie, additional, Cailliez, Valérie, additional, Boillot, Olivier, additional, Pageaux, Georges Philippe, additional, Samuel, Didier, additional, Calmus, Yvon, additional, and Dumortier, Jérôme, additional

Published
2020
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143. Impact of COVID‐19 on liver transplantation in Europe: alert from an early survey of European Liver and Intestine Transplantation Association and European Liver Transplant Registry

Author

Polak, Wojciech G., primary, Fondevila, Constantino, additional, Karam, Vincent, additional, Adam, Rene, additional, Baumann, Ulrich, additional, Germani, Giacomo, additional, Nadalin, Silvio, additional, Taimr, Pavel, additional, Toso, Christian, additional, Troisi, Roberto I., additional, Zieniewicz, Krzysztof, additional, Belli, Luca S., additional, and Duvoux, Christophe, additional

Published
2020
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144. Long-term patient and graft survival after liver transplantation for autoimmune hepatitis

Author

Heinemann, Melina, primary, Adam, René, additional, Haym, Marina Berenguer, additional, Mirza, Darius F., additional, Malek-Hosseini, Seyed Ali, additional, O’Grady, John G., additional, Hidalgo, Ernest, additional, Pratschke, Johann, additional, Boudjema, Karim, additional, Paul, Andreas, additional, Zieniewicz, Krzysztof, additional, Fronek, Jiri, additional, Weiss, Karl Heinz, additional, Karam, Vincent, additional, Duvoux, Christophe, additional, Lohse, Ansgar, additional, and Schramm, Christoph, additional

Published
2020
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145. Early liver transplantation for severe alcoholic hepatitis not responding to medical treatment: results of the French-Belgian prospective study QuickTrans

Author

Louvet, Alexandre, primary, Labreuche, Julien, additional, Moreno, Christophe, additional, Vanlemmens, Claire, additional, Moirand, Romain, additional, Feray, Cyrille, additional, Dumortier, Jérôme, additional, Pageaux, Georges-Philippe, additional, Bureau, Christophe, additional, Chermak, Faiza, additional, Duvoux, Christophe, additional, Thabut, Dominique, additional, Leroy, Vincent, additional, Carbonell, Nicolas, additional, Salamé, Ephrem, additional, Anty, Rodolphe, additional, Gournay, Jérôme, additional, Delwaide, Jean, additional, Silvain, Christine, additional, Lassailly, Guillaume, additional, Dharancy, Sebastien, additional, Khac, Eric Nguyen, additional, Samuel, Didier, additional, Duhamel, Alain, additional, and Mathurin, Philippe, additional

Published
2020
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146. International, multicenter study on the outcome of locoregional therapy before liver transplant for hepatocellular carcinoma extending the Milan criteria

Author

Degroote, Helena, primary, Piñero, Federico, additional, Costentin, Charlotte, additional, Notarpaolo, Andrea, additional, Boin, Ilka F., additional, Boudjema, Karim, additional, Baccaro, Cinzia, additional, Podestá, Luis G., additional, Bachellier, Philippe, additional, Ettorre, Giuseppe Maria, additional, Poniachik, Jaime, additional, Muscari, Fabrice, additional, Di Benedetto, Fabrizio, additional, Duque, Sergio Hoyos, additional, Salamé, Ephrem, additional, Cillo, Umberto, additional, Gadano, Adrian, additional, Vanlemmens, Claire, additional, Fagiuoli, Stefano, additional, Rubinstein, Fernando, additional, Burra, Patrizia, additional, Silva, Marcelo, additional, Van Vlierberghe, Hans, additional, and Duvoux, Christophe, additional

Published
2020
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147. Wide variations in liver transplantation (LT) policies across Europe for patients with acute-on-chronic liver failure (ACLF) despite excellent post-LT survival: Results of a CLIF/ELITA collaborative study

Author

Belli, Luca Saverio, primary, Duvoux, Christophe, additional, Perricone, Giovanni, additional, Pageaux, Georges-Philippe, additional, Meszaros, Magdalena, additional, Artzner, Thierry, additional, Michard, Baptiste, additional, Radenne, Sylvie, additional, Céline, Dr. Guichon, additional, Saliba, Faouzi, additional, Sacleux, Sophie-Caroline, additional, Fernández, Javier, additional, Hernandetz, Maria, additional, Angeli, Paolo, additional, Bernal, William, additional, Morelli, Maria Cristina, additional, Martini, Silvia, additional, Trebicka, Jonel, additional, Zieniewicz, Krzysztof, additional, Nadalin, Silvio, additional, Fondevila, Constantino, additional, Polak, Wojciech, additional, Toso, Christian, additional, Invernizzi, Federica, additional, Volpes, Riccardo, additional, Iegri, Claudia, additional, Haym, Marina Berenguer, additional, Cortesi, Paolo, additional, Conti, Sara, additional, Katarey, Dev, additional, Jalan, Rajiv, additional, and Arroyo, Vicente, additional

Published
2020
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148. COVID-19 in liver transplant recipients: preliminary data from the ELITA/ELTR registry

Author

Belli, Luca S, primary, Duvoux, Christophe, additional, Karam, Vincent, additional, Adam, Rene, additional, Cuervas-Mons, Valentin, additional, Pasulo, Luisa, additional, Loinaz, Carmelo, additional, Invernizzi, Federica, additional, Patrono, Damiano, additional, Bhoori, Sherrie, additional, Ciccarelli, Olga, additional, Morelli, Maria Cristina, additional, Castells, Lluis, additional, Lopez-Lopez, Victor, additional, Conti, Sara, additional, Fondevila, Costantino, additional, and Polak, Wojchiech, additional

Published
2020
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149. Reassessment of the risk of recurrence (R3) after liver transplantation for HCC: validation of the R3 v.2 score and comparison with existing models: results of a multinational analysis in 2,444 patients

Author

Costentin, Charlotte, primary, Pinero, Federico, additional, Degroote, Helena, additional, Notarpaolo, Andrea, additional, Boin, Ilka, additional, Boudjema, Karim, additional, Baccaro, Cinzia, additional, Podestá, Luis G., additional, Bachellier, Philippe, additional, Ettorre, Giuseppe Maria, additional, Poniachik, Jaime, additional, Muscari, Fabrice, additional, Di Benedetto, Fabrizio, additional, Duque, Sergio Hoyos, additional, Salamé, Ephrem, additional, Cillo, Umberto, additional, Gadano, Adrian, additional, Vanlemmens, Claire, additional, Fagiuoli, Stefano, additional, Rubinstein, Fernando, additional, Burra, Patrizia, additional, Van Vlierberghe, Hans, additional, Silva, Marcelo, additional, and Duvoux, Christophe, additional

Published
2020
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150. Liver transplantation in patients with sickle cell disease: possible but challenging—a cohort study

Author

Levesque, Eric, primary, Lim, Chetana, additional, Feray, Cyrille, additional, Salloum, Chady, additional, Quere, Anne‐Laure, additional, Robin, Benoit, additional, Merle, Jean‐Claude, additional, Esposito, Francesco, additional, Duvoux, Christophe, additional, Cherqui, Daniel, additional, Habibi, Anoosha, additional, Galacteros, Frédéric, additional, Bartolucci, Pablo, additional, and Azoulay, Daniel, additional

Published
2020
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